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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDCA5 Gene

protein-coding GIFtS: 53
GCID: GC11M064833

cell division cycle associated 5

Explore 1 disease affiliated with
CDCA5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle Associated 5¹ ²
Cell Division Cycle-Associated Protein 5² ³
P35¹
SORORIN² ⁵
Sororin¹

External Ids:	HGNC: 14626¹	Entrez Gene: 113130²	Ensembl: ENSG00000146670⁷	OMIM: 609374⁵	UniProtKB: Q96FF9³

Export aliases for CDCA5 gene to outside databases

Previous GC identifers: GC11U990624 GC11M065095 GC11M064620 GC11M064601 GC11M064844 GC11M061171

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9

Function: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May

antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome

partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for

efficient DNA double-stranded break repair

Gene Wiki entry for CDCA5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDCA5 gene promoter:
SRF ISGF-3 p53 SRF (504 AA) FOXO1a Pax-4a C/EBPalpha FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDCA5 promoter sequence

Search SABiosciences Chromatin IP Primers for CDCA5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

CDCA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA5 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M064833: view genomic region (about GC identifiers)

Start:	64,833,772 bp from pter	End:	64,851,636 bp from pter
Size:	17,865 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9 (See protein sequence)

Recommended Name: Sororin

Size: 252 amino acids; 27601 Da

Subunit: Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the

interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3.

Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A

with WAPAL

Subcellular location: Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until

metaphase and is released in the cytoplasm upon nuclear envelope breakdown

Miscellaneous: Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister

chromatid cohesion

Secondary accessions: A8K625

Explore the universe of human proteins at neXtProt for CDCA5: NX_Q96FF9

Post-translational modifications:

Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the

inhibition of WAPAL by CDCA5¹

Ubiquitinated by the APC/C complex in G1, leading to its degradation (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96FF9

CDCA5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_542399.1

ENSEMBL proteins:

ENSP00000432183 ENSP00000432342 ENSP00000275517 ENSP00000431888 ENSP00000385711

ENSP00000432621 ENSP00000414881

Reactome Protein details: Q96FF9
Human Recombinant Protein Products for CDCA5:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDCA5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	ISS	--
GO:0005634	nucleus	ISS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	ISS	--
GO:0005886	plasma membrane	IDA	--

CDCA5 for ontologies About GeneDecksing

CDCA5 Antibody Products:

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	Uscn ELISAs and CLIAs for CDCA5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDCA5 for domains About GeneDecksing

1 InterPro domain/family:

IPR018605 Sororin

Graphical View of Domain Structure for InterPro Entry Q96FF9

ProtoNet protein and cluster: Q96FF9

UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9

Domain: The KEN box is required for the association with the APC/C complex (By similarity)

Similarity: Belongs to the sororin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDCA5_HUMAN, Q96FF9

Function: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May

antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome

partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for

efficient DNA double-stranded break repair

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	TAS	15837422
GO:0005515	protein binding	IPI	--

CDCA5 for ontologies About GeneDecksing

Phenotypes:
11 GenomeRNAi human phenotypes for CDCA5:

Abundance of large cells with	Cell cycle / mitosis defect	Cell division defect	Decreased cell number, increas
Decreased viability of wild-ty	Increased Salmonella enterica	Increased cell death in breast	Increased cell number in G2M,
Increased gamma-H2AX phosphory	Increased number of cells in m	Increased number of mitotic ce

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDCA5

miRNA Products:		OriGene 3'-UTR Clone: CDCA5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA5
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA5:
		hsa-miR-221* hsa-miR-1321 hsa-miR-4286 hsa-let-7g* hsa-let-7a-2* hsa-miR-1286 hsa-miR-1205
		SwitchGear 3'UTR luciferase reporter plasmid: CDCA5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDCA5 (see all 7) OriGene shRNA RFP: CDCA5 OriGene siRNA: CDCA5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Cohesin Loading onto Chromatin

Establishment of Sister Chromatid Cohesion

0.62

Ubiquitinated Orc1 is degraded by the proteasome

S Phase

0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 Reactome Pathways for CDCA5 (see all 12)

	Mitotic Metaphase and Anaphase
	Establishment of Sister Chromatid Cohesion
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase

CDCA5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDCA5

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/22 Interacting proteins for CDCA5 (Q96FF9^{1, 2, 3} ENSP00000275517⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC6	P12956²^,³, ENSP00000352257⁴	MINT-65145 I2D: score=5 STRING: ENSP00000352257
PDS5A	Q29RF7¹^,³, ENSP00000303427⁴	EBI-718805,EBI-2554552 I2D: score=2 STRING: ENSP00000303427
SMC3	Q9UQE7³, ENSP00000354720⁴	I2D: score=2 STRING: ENSP00000354720
PDS5B	Q9NTI5³, ENSP00000313851⁴	I2D: score=2 STRING: ENSP00000313851
RAD21	O60216³, ENSP00000297338⁴	I2D: score=1 STRING: ENSP00000297338

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IDA	15837422
GO:0006302	double-strand break repair	IMP	17349791
GO:0007064	mitotic sister chromatid cohesion	IMP	17349791
GO:0007067	mitosis	IDA	15837422
GO:0007076	mitotic chromosome condensation	IMP	15837422

CDCA5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDCA5
Search CenterWatch for drugs/clinical trials and news about CDCA5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDCA5 gene:

NM_080668.3

Unigene Cluster for CDCA5:

Cell division cycle associated 5

Hs.434886 [show with all ESTs]

Unigene Representative Sequence: NM_080668

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000529290 ENST00000525464 ENST00000533015 ENST00000275517(uc001ocp.2)

ENST00000524733 ENST00000404147 ENST00000479032 ENST00000531401 ENST00000527430

ENST00000462902 ENST00000438878(uc001oco.3)

miRNA Products:		OriGene 3'-UTR Clone: CDCA5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA5
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA5:
		hsa-miR-221* hsa-miR-1321 hsa-miR-4286 hsa-let-7g* hsa-let-7a-2* hsa-miR-1286 hsa-miR-1205
		SwitchGear 3'UTR luciferase reporter plasmid: CDCA5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDCA5 (see all 7) OriGene shRNA RFP: CDCA5 OriGene siRNA: CDCA5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCA5
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDCA5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDCA5 (NM_080668)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA5
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDCA5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCA5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA5

Additional cDNA sequence:

AK093670.1 AK291490.1 AL832526.1 BC011000.2

8 DOTS entries:

DT.443629 DT.100802249 DT.95254179 DT.92452053 DT.95227834 DT.101979301 DT.91685179 DT.92452047

24/311 AceView cDNA sequences (see all 311):

BE563266 BQ685550 AW166947 BM480129 AI097444 BU557980 BQ644959 BM550759

AA662530 BQ064533 BQ441652 BM554537 AA991349 BM699162 AI138924 BF983582

AI805421 CR614636 AW615722 BU508071 BG114326 BQ648028 AA588878 AA631344

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA5 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6
SP1:							-										-
SP2:							-		-
SP3:
SP4:

ECgene alternative splicing isoforms for CDCA5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDCA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCTGGAG

About this image

CDCA5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Testis Cord

XY Germ Cells

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See CDCA5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDCA5

SOURCE GeneReport for Unigene cluster: Hs.434886

SABiosciences Custom PCR Arrays for CDCA5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDCA5 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdca5^{1 , 5}	cell division cycle associated 5^{1, 5}	75.17(n)¹ 72.06(a)¹		19 (4.34 cM)⁵ 67849¹ NM_026410.3¹ NP_080686.1¹ 6084983⁵
lizard (Anolis carolinensis)	Reptilia	-- --	--	40(a) 32(a)	many → 1 many → 1	AAWZ02037296(209-3214) 1(233984071-233984838)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12922²	Xenopus laevis transcribed sequence with weak similarity more	77.17(n)		BJ075269.1
zebrafish (Danio rerio)	Actinopterygii	cdca5⁶	cell division cycle associated 5	26(a)	1 ↔ 1	5(70170756-70176273)

ENSEMBL Gene Tree for CDCA5 (if available)
TreeFam Gene Tree for CDCA5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142234104^1,2		--	64844673(+)	`AGAATC/TGCTTG`	1	--	int¹		0	--	--	--	--
rs1152608^1,2	C,H	--	64844809(+)	`GAATGG/CGGGGA`	1	--	int¹		8		NA WA CSA	15
rs184430778^1,2		--	64844829(+)	`GGGAGC/TGCCTG`	1	--	int¹		0	--	--	--	--
rs112340113^1,2		--	64844887(+)	`ACCTTC/TGGCTC`	1	--	int¹		1		CSA	2
rs141166328^1,2		--	64845094(+)	`GAGTTC/GTGCTG`	1	--	ut3¹		0	--	--	--	--
rs146945787^1,2		--	64845202(+)	`AGAGCA/GTTGAG`	1	--	ut3¹		0	--	--	--	--
rs147595222^1,2		--	64845217(+)	`TGGCCC/TGGGAC`	1	--	ut3¹		0	--	--	--	--
rs142504769^1,2		--	64845256(+)	`GGCCCA/GCCTGG`	1	--	ut3¹		0	--	--	--	--
rs150241754^1,2		--	64845436(+)	`AAATCC/GACACT`	1	--	ut3¹		0	--	--	--	--
rs489489^1,2	C,F,A,H	--	64845438(+)	`ATCCAC/AACTAT`	1	--	ut3¹ ese³		28		MN EA NA NS WA CSA	4312

HapMap Linkage Disequilibrium report for CDCA5 (64833772 - 64851636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDCA5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDCA5

DNA2.0 Custom Variant and Variant Library Synthesis for CDCA5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDCA5 for disorders           About GeneDecksing

OMIM gene information: 609374    OMIM disorders: --

1 disease for CDCA5:    About MalaCards

roberts syndrome

1 disease from the University of Copenhagen DISEASES database for CDCA5:

Roberts syndrome

Human Genome Epidemiology (HuGE) Navigator: CDCA5 (1 document)

Export disorders for CDCA5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDCA5 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with CDCA5)

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Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (PubMed id 15837422)^{1, 2, 3, 9} Rankin S.... Kirschner M.W. (2005)
Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)^{1, 2, 3} Walker M.G. (2001)
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. (PubMed id 17349791)^{1, 2, 9} Schmitz J....Peters J.M. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Regulation of centromeric cohesion by sororin independently of the APC/C. (PubMed id 17361102)^{1, 9} Diaz-Martinez L.A....Clarke D.J. (2007)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A conserved motif at the C terminus of sororin is req uired for sister chromatid cohesion. (PubMed id 21115494)¹ Wu F.M....Rankin S. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 113130	HGNC: 14626	AceView: CDCA5	Ensembl:ENSG00000146670	euGenes: HUgn113130
ECgene: CDCA5	H-InvDB: CDCA5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDCA5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDCA5 gene
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Patent Information for CDCA5 gene:
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cell division cycle associated 5

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cell division cycle associated 5

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