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CDCA5 Gene

protein-coding   GIFtS: 59
GCID: GC11M064833

Cell Division Cycle Associated 5

  See CDCA5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle Associated 51 2
sororin1 2
Cell Division Cycle-Associated Protein 52 3
p352 3
SORORIN2 5

External Ids:    HGNC: 146261   Entrez Gene: 1131302   Ensembl: ENSG000001466707   OMIM: 6093745   UniProtKB: Q96FF93   

Export aliases for CDCA5 gene to outside databases

Previous GC identifers: GC11U990624 GC11M065095 GC11M064620 GC11M064601 GC11M064844 GC11M061171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDCA5 Gene:
CDCA5 (cell division cycle associated 5) is a protein-coding gene. Diseases associated with CDCA5 include roberts syndrome. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9
Function: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with
chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion
ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in
DNA repair. Required for efficient DNA double-stranded break repair

Gene Wiki entry for CDCA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDCA5 gene promoter:
         SRF   ISGF-3   p53   SRF (504 AA)   FOXO1a   Pax-4a   C/EBPalpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCA5 promoter sequence
   Search Chromatin IP Primers for CDCA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDCA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

CDCA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064833:  view genomic region     (about GC identifiers)

Start:
64,833,772 bp from pter      End:
64,851,636 bp from pter
Size:
17,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9 (See protein sequence)
Recommended Name: Sororin  
Size: 252 amino acids; 27601 Da
Subunit: Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the
interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3.
Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of
PDS5A with WAPAL
Miscellaneous: Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in
sister chromatid cohesion
Secondary accessions: A8K625

Explore the universe of human proteins at neXtProt for CDCA5: NX_Q96FF9

Explore proteomics data for CDCA5 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the
    inhibition of WAPAL by CDCA51
  • Ubiquitinated by the APC/C complex in G1, leading to its degradation (Probable)1
  • Ubiquitination2 at Lys99
  • Modification sites at PhosphoSitePlus

  • See CDCA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542399.1  
    ENSEMBL proteins: 
     ENSP00000432183   ENSP00000432342   ENSP00000275517   ENSP00000431888   ENSP00000385711  
     ENSP00000432621   ENSP00000414881  
    Reactome Protein details: Q96FF9

    CDCA5 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDCA5

     
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    antibodies-online proteins for CDCA5 (5 products) 

     
    antibodies-online peptides for CDCA5

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    antibodies-online antibodies for CDCA5 (20 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018605 Sororin

    Graphical View of Domain Structure for InterPro Entry Q96FF9

    ProtoNet protein and cluster: Q96FF9

    UniProtKB/Swiss-Prot: CDCA5_HUMAN, Q96FF9
    Domain: The KEN box is required for the association with the APC/C complex (By similarity)
    Similarity: Belongs to the sororin family


    Find genes that share domains with CDCA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCA5_HUMAN, Q96FF9
    Function: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with
    chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion
    ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in
    DNA repair. Required for efficient DNA double-stranded break repair

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS15837422
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CDCA5           About GenesLikeMe


    Phenotypes:
         11 GenomeRNAi human phenotypes for CDCA5:
     Abundance of large cells with   Cell cycle / mitosis defect  Cell division defect  Decreased cell number, increas 
     Decreased viability of wild-ty  Increased Salmonella enterica   Increased cell death in breast  Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Increased number of cells in m  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDCA5
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CDCA5:
    hsa-mir-193b-3p (MIRT016488), hsa-mir-18b-5p (MIRT042416), hsa-mir-18a-5p (MIRT050732)

    Block miRNA regulation of human, mouse, rat CDCA5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CDCA5:
    hsa-miR-221* hsa-miR-1321 hsa-miR-4286 hsa-let-7g* hsa-let-7a-2* hsa-miR-1286 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidCDCA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDCA5

    Gene Editing
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    Sino Biological Human cDNA Clone for CDCA5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDCA5_HUMAN, Q96FF9: Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until
    metaphase and is released in the cytoplasm upon nuclear envelope breakdown
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    Find genes that share ontologies with CDCA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDCA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with CDCA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for CDCA5
        Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids


    1 Kegg Pathway  (Kegg details for CDCA5):
        MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDCA5
    Interactions:

        Search GeneGlobe Interaction Network for CDCA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CDCA5 (Q96FF91, 2, 3 ENSP000002755174) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-65145 I2D: score=5 STRING: ENSP00000352257
    PDS5AQ29RF71, 3, ENSP000003034274EBI-718805,EBI-1175454 I2D: score=2 STRING: ENSP00000303427
    SMC3Q9UQE73, ENSP000003547204I2D: score=2 STRING: ENSP00000354720
    PDS5BQ9NTI53, ENSP000003138514I2D: score=2 STRING: ENSP00000313851
    RAD21O602163, ENSP000002973384I2D: score=1 STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA15837422
    GO:0000278mitotic cell cycle TAS--
    GO:0006302double-strand break repair IMP17349791
    GO:0007064mitotic sister chromatid cohesion IMP17349791
    GO:0007067mitosis IDA15837422

    Find genes that share ontologies with CDCA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDCA5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDCA5 gene: 
    NM_080668.3  

    Unigene Cluster for CDCA5:

    Cell division cycle associated 5
    Hs.434886  [show with all ESTs]
    Unigene Representative Sequence: NM_080668
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529290 ENST00000525464 ENST00000533015 ENST00000275517(uc001ocp.2)
    ENST00000524733 ENST00000404147 ENST00000479032 ENST00000531401 ENST00000527430
    ENST00000462902 ENST00000438878(uc001oco.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CDCA5:
    hsa-miR-221* hsa-miR-1321 hsa-miR-4286 hsa-let-7g* hsa-let-7a-2* hsa-miR-1286 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidCDCA5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CDCA5 (NM_080668)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDCA5
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDCA5
      QuantiTect SYBR Green Assays in human, mouse, rat CDCA5
      QuantiFast Probe-based Assays in human, mouse, rat CDCA5

    Additional mRNA sequence: 

    AK093670.1 AK291490.1 AL832526.1 BC011000.2 

    8 DOTS entries:

    DT.443629  DT.100802249  DT.95254179  DT.92452053  DT.95227834  DT.101979301  DT.91685179  DT.92452047 

    Selected AceView cDNA sequences (see all 311):

    BU678279 AL079372 AL832526 AI805421 BF983582 BM699162 AI138924 BM982693 
    BM974676 BC011000 AA631344 CR614636 AA588878 AA627087 BE206259 BI226126 
    BU508071 BG114326 BG393387 BM759067 AA588606 BQ438240 BQ953112 AF055882 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                    -                             -               
    SP2:                    -     -                                       
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for CDCA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDCA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCTGGAG
    CDCA5 Expression
    About this image


    CDCA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    CDCA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDCA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434886
        Custom PCR Arrays for CDCA5
    Primer
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    OriGene qPCR primer pairs and template standards for CDCA5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDCA5
    QuantiTect SYBR Green Assays in human, mouse, rat CDCA5
    QuantiFast Probe-based Assays in human, mouse, rat CDCA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdca51 , 5 cell division cycle associated 51, 5 74.9(n)1
    71.26(a)1
      19 (4.34 cM)5
    678491  NM_026410.31  NP_080686.11 
     60849835 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129222 Xenopus laevis transcribed sequence with weak similarity more 77.17(n)    BJ075269.1 


    ENSEMBL Gene Tree for CDCA5 (if available)
    TreeFam Gene Tree for CDCA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDCA5 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422341041,2
    C--64844673(+) AGAATC/TGCTTG 1 -- int10--------
    rs11526081,2
    C,H--64844809(+) GAATGG/CGGGGA 1 -- int18Minor allele frequency- C:0.07NA WA CSA 15
    rs1844307781,2
    C--64844829(+) GGGAGC/TGCCTG 1 -- int10--------
    rs1123401131,2
    F--64844887(+) ACCTTC/TGGCTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1411663281,2
    --64845094(+) GAGTTC/GTGCTG 1 -- ut310--------
    rs1469457871,2
    C--64845202(+) AGAGCA/GTTGAG 1 -- ut310--------
    rs1475952221,2
    --64845217(+) TGGCCC/TGGGAC 1 -- ut310--------
    rs1425047691,2
    C--64845256(+) GGCCCA/GCCTGG 1 -- ut310--------
    rs1502417541,2
    C--64845436(+) AAATCC/GACACT 1 -- ut310--------
    rs4894891,2
    C,F,A,H--64845438(+) ATCCAC/AACTAT 1 -- ut31 ese328Minor allele frequency- A:0.25MN EA NA NS WA CSA 4312

    HapMap Linkage Disequilibrium report for CDCA5 (64833772 - 64851636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDCA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609374    OMIM disorders: --

    1 disease for CDCA5:    
    About MalaCards
    roberts syndrome

    1 disease from the University of Copenhagen DISEASES database for CDCA5:
    Roberts syndrome

    Find genes that share disorders with CDCA5           About GenesLikeMe

    Genetic Association Database (GAD): CDCA5
    Human Genome Epidemiology (HuGE) Navigator: CDCA5 (1 document)

    Export disorders for CDCA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDCA5 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CDCA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (PubMed id 15837422)1, 2, 3, 9 Rankin S.... Kirschner M.W. (Mol. Cell 2005)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (Curr. Cancer Drug Targets 2001)
    3. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. (PubMed id 17349791)1, 2, 9 Schmitz J.... Peters J.M. (Curr. Biol. 2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PubMed id 21111234)1, 2 Nishiyama T....Peters J.M. (Cell 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Regulation of centromeric cohesion by sororin independently of the APC/C. (PubMed id 17361102)1, 9 DA-az-MartA-nez L.A....Clarke D.J. (Cell Cycle 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113130 HGNC: 14626 AceView: CDCA5 Ensembl:ENSG00000146670 euGenes: HUgn113130
    ECgene: CDCA5 Kegg: 113130 H-InvDB: CDCA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDCA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDCA5 gene:
    Search GeneIP for patents involving CDCA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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