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Aliases for CDCA4 Gene

Aliases for CDCA4 Gene

  • Cell Division Cycle Associated 4 2 3 5
  • Hematopoietic Progenitor Protein 2 3 4
  • HEPP 3 4
  • SEI-3/HEPP 3

External Ids for CDCA4 Gene

Previous GeneCards Identifiers for CDCA4 Gene

  • GC14M102854
  • GC14M099467
  • GC14M103447
  • GC14M104547
  • GC14M105557
  • GC14M105559
  • GC14M085669
  • GC14M105562
  • GC14M105567
  • GC14M105570
  • GC14M105576
  • GC14M105591
  • GC14M105598
  • GC14M105605

Summaries for CDCA4 Gene

Entrez Gene Summary for CDCA4 Gene

  • This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

GeneCards Summary for CDCA4 Gene

CDCA4 (Cell Division Cycle Associated 4) is a Protein Coding gene. An important paralog of this gene is SERTAD2.

UniProtKB/Swiss-Prot for CDCA4 Gene

  • May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA4 Gene

Genomics for CDCA4 Gene

Regulatory Elements for CDCA4 Gene

Promoters for CDCA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDCA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDCA4 Gene

Chromosome:
14
Start:
105,009,573 bp from pter
End:
105,021,148 bp from pter
Size:
11,576 bases
Orientation:
Minus strand

Genomic View for CDCA4 Gene

Genes around CDCA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA4 Gene

Proteins for CDCA4 Gene

  • Protein details for CDCA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXL8-CDCA4_HUMAN
    Recommended name:
    Cell division cycle-associated protein 4
    Protein Accession:
    Q9BXL8
    Secondary Accessions:
    • Q8TB18
    • Q9NWK7

    Protein attributes for CDCA4 Gene

    Size:
    241 amino acids
    Molecular mass:
    26114 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDCA4 Gene

Proteomics data for CDCA4 Gene at MOPED

Post-translational modifications for CDCA4 Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDCA4 Gene

Domains & Families for CDCA4 Gene

Protein Domains for CDCA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXL8

UniProtKB/Swiss-Prot:

CDCA4_HUMAN :
  • Contains 1 SERTA domain.
Domain:
  • Contains 1 SERTA domain.
genes like me logo Genes that share domains with CDCA4: view

No data available for Gene Families for CDCA4 Gene

Function for CDCA4 Gene

Molecular function for CDCA4 Gene

UniProtKB/Swiss-Prot Function:
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By E2F1.
genes like me logo Genes that share phenotypes with CDCA4: view

Animal Model Products

miRNA for CDCA4 Gene

miRTarBase miRNAs that target CDCA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA4 Gene

Localization for CDCA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA4 Gene COMPARTMENTS Subcellular localization image for CDCA4 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CDCA4 Gene

Pathways & Interactions for CDCA4 Gene

SuperPathways for CDCA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDCA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDCA4 Gene

Drugs & Compounds for CDCA4 Gene

(1) Additional Compounds for CDCA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDCA4: view

Transcripts for CDCA4 Gene

mRNA/cDNA for CDCA4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDCA4 Gene

Cell division cycle associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA4 Gene

No ASD Table

Relevant External Links for CDCA4 Gene

GeneLoc Exon Structure for
CDCA4
ECgene alternative splicing isoforms for
CDCA4

Expression for CDCA4 Gene

mRNA expression in normal human tissues for CDCA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDCA4 Gene

This gene is overexpressed in Heart (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDCA4 Gene



SOURCE GeneReport for Unigene cluster for CDCA4 Gene Hs.34045

mRNA Expression by UniProt/SwissProt for CDCA4 Gene

Q9BXL8-CDCA4_HUMAN
Tissue specificity: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with CDCA4: view

Protein tissue co-expression partners for CDCA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDCA4 Gene

Orthologs for CDCA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA4 35
  • 99.01 (n)
  • 99.5 (a)
CDCA4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA4 36
  • 65 (a)
OneToOne
CDCA4 35
  • 74.36 (n)
  • 66.97 (a)
dog
(Canis familiaris)
Mammalia CDCA4 35
  • 78.28 (n)
  • 73.86 (a)
CDCA4 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca4 16
Cdca4 36
  • 73 (a)
OneToOne
Cdca4 35
  • 75.81 (n)
  • 74.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CDCA4 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA4 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca4 35
  • 75.25 (n)
  • 73.42 (a)
chicken
(Gallus gallus)
Aves CDCA4 36
  • 61 (a)
OneToOne
CDCA4 35
  • 65.83 (n)
  • 65.69 (a)
lizard
(Anolis carolinensis)
Reptilia CDCA4 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33531 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca4 35
  • 62.36 (n)
  • 58.75 (a)
zebrafish
(Danio rerio)
Actinopterygii CDCA4 36
  • 42 (a)
OneToOne
si:dkey-177p2.7 35
  • 56.72 (n)
  • 52.94 (a)
Species with no ortholog for CDCA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA4 Gene

ENSEMBL:
Gene Tree for CDCA4 (if available)
TreeFam:
Gene Tree for CDCA4 (if available)

Paralogs for CDCA4 Gene

Paralogs for CDCA4 Gene

Pseudogenes.org Pseudogenes for CDCA4 Gene

genes like me logo Genes that share paralogs with CDCA4: view

Variants for CDCA4 Gene

Sequence variations from dbSNP and Humsavar for CDCA4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs4309336 -- 105,016,036(+) CCTGG(A/T)TTCCA intron-variant
rs4570772 -- 105,013,913(+) AAATC(G/T)GAAAC intron-variant
rs4577017 -- 105,013,900(+) TTGTA(A/G)TAGCT intron-variant
rs4577018 -- 105,013,903(+) TAGTA(A/G)CTCCA intron-variant
rs3923887 -- 105,014,172(+) GATCT(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA4 Gene

Variant ID Type Subtype PubMed ID
dgv2019n71 CNV Loss 21882294
nsv902421 CNV Loss 21882294
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294

Variation tolerance for CDCA4 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA4 Gene

HapMap Linkage Disequilibrium report
CDCA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA4 Gene

Disorders for CDCA4 Gene

Relevant External Links for CDCA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA4

No disorders were found for CDCA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCA4 Gene

Publications for CDCA4 Gene

  1. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. (PMID: 16984923) Hayashi R. … Yoshida K. (J. Biol. Chem. 2006) 3 4 23 67
  2. Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. (PMID: 11482882) Abdullah J.M. … Jurecic R. (Blood Cells Mol. Dis. 2001) 3 23
  3. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CDCA4 Gene

Sources for CDCA4 Gene

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