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Aliases for CDCA4 Gene

Aliases for CDCA4 Gene

  • Cell Division Cycle Associated 4 2 3 5
  • Hematopoietic Progenitor Protein 2 3 4
  • HEPP 3 4
  • Cell Division Cycle-Associated Protein 4 3
  • SEI-3/HEPP 3

External Ids for CDCA4 Gene

Previous GeneCards Identifiers for CDCA4 Gene

  • GC14M102854
  • GC14M099467
  • GC14M103447
  • GC14M104547
  • GC14M105557
  • GC14M105559
  • GC14M085669
  • GC14M105562
  • GC14M105567
  • GC14M105570
  • GC14M105576
  • GC14M105591
  • GC14M105598
  • GC14M105605

Summaries for CDCA4 Gene

Entrez Gene Summary for CDCA4 Gene

  • This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

GeneCards Summary for CDCA4 Gene

CDCA4 (Cell Division Cycle Associated 4) is a Protein Coding gene. An important paralog of this gene is SERTAD2.

UniProtKB/Swiss-Prot for CDCA4 Gene

  • May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).

Additional gene information for CDCA4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA4 Gene

Genomics for CDCA4 Gene

GeneHancer (GH) Regulatory Elements for CDCA4 Gene

Promoters and enhancers for CDCA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I105013 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 560.8 -0.2 -211 14.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 CDCA4 CLBA1 GPR132 AHNAK2 PIR49972 GC14P105029
GH14I104665 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.2 +354.6 354638 2.9 HDGF FOXA2 YBX1 DMAP1 ZBTB7B ZNF302 ZNF207 FOS SP5 ZHX2 LINC02280 MTA1 XRCC3 ENSG00000257270 CDCA4 LINC00638 BRF1 ENSG00000270591 TMEM121 RPS20P33
GH14I104814 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 29.5 +205.4 205350 2.8 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ENSG00000279140 MTA1 LINC00638 ENSG00000257270 CDCA4 TMEM121 PACS2 CEP170B CRIP2
GH14I105566 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 32.7 -548.6 -548582 6.2 HDGF ZNF133 NEUROD1 YBX1 GLI4 ZNF48 ZNF2 ZBTB7B GLIS2 ZNF207 MTA1 ENSG00000257270 CDCA4 ENSG00000225200 RPS20P33 CEP170B GPR132 LINC00638 AKT1 IGHA2
GH14I104979 Enhancer 1.2 ENCODE dbSUPER 33.6 +40.0 39985 4 ZNF133 FEZF1 GLI4 ZNF2 ZBTB7B YY1 GLIS2 ZNF207 ZNF548 FOS MTA1 ENSG00000257270 CDCA4 CLBA1 IGHGP ENSG00000225200 TMEM121 RPS20P33 PACS2 AKT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDCA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDCA4 gene promoter:

Genomic Locations for CDCA4 Gene

Genomic Locations for CDCA4 Gene
11,576 bases
Minus strand

Genomic View for CDCA4 Gene

Genes around CDCA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA4 Gene

Proteins for CDCA4 Gene

  • Protein details for CDCA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell division cycle-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8TB18
    • Q9NWK7

    Protein attributes for CDCA4 Gene

    241 amino acids
    Molecular mass:
    26114 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDCA4 Gene

Post-translational modifications for CDCA4 Gene

Other Protein References for CDCA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA4 Gene

Domains & Families for CDCA4 Gene

Gene Families for CDCA4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDCA4 Gene


Suggested Antigen Peptide Sequences for CDCA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA4: view

No data available for UniProtKB/Swiss-Prot for CDCA4 Gene

Function for CDCA4 Gene

Molecular function for CDCA4 Gene

UniProtKB/Swiss-Prot Function:
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By E2F1.

Phenotypes From GWAS Catalog for CDCA4 Gene

Gene Ontology (GO) - Molecular Function for CDCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with CDCA4: view
genes like me logo Genes that share phenotypes with CDCA4: view

Animal Model Products

CRISPR Products

miRNA for CDCA4 Gene

miRTarBase miRNAs that target CDCA4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA4 Gene

Localization for CDCA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA4 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CDCA4: view

Pathways & Interactions for CDCA4 Gene

SuperPathways for CDCA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA4: view

No data available for Pathways by source and SIGNOR curated interactions for CDCA4 Gene

Drugs & Compounds for CDCA4 Gene

(1) Additional Compounds for CDCA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDCA4: view

Transcripts for CDCA4 Gene

mRNA/cDNA for CDCA4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDCA4 Gene

Cell division cycle associated 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA4 Gene

No ASD Table

Relevant External Links for CDCA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDCA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDCA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDCA4 Gene

This gene is overexpressed in Heart (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDCA4 Gene

Protein tissue co-expression partners for CDCA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDCA4 Gene:


SOURCE GeneReport for Unigene cluster for CDCA4 Gene:


mRNA Expression by UniProt/SwissProt for CDCA4 Gene:

Tissue specificity: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for CDCA4 Gene

  • Skin(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with CDCA4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA4 Gene

Orthologs for CDCA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDCA4 33 34
  • 99.01 (n)
(Canis familiaris)
Mammalia CDCA4 33 34
  • 78.28 (n)
(Mus musculus)
Mammalia Cdca4 33 16 34
  • 75.81 (n)
(Rattus norvegicus)
Mammalia Cdca4 33
  • 75.25 (n)
(Bos Taurus)
Mammalia CDCA4 33 34
  • 74.36 (n)
(Monodelphis domestica)
Mammalia CDCA4 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia CDCA4 34
  • 61 (a)
(Gallus gallus)
Aves CDCA4 33 34
  • 65.83 (n)
(Anolis carolinensis)
Reptilia CDCA4 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca4 33
  • 62.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33531 33
(Danio rerio)
Actinopterygii si:dkey-177p2.7 33
  • 56.72 (n)
CDCA4 34
  • 42 (a)
Species where no ortholog for CDCA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA4 Gene

Gene Tree for CDCA4 (if available)
Gene Tree for CDCA4 (if available)

Paralogs for CDCA4 Gene

Paralogs for CDCA4 Gene Pseudogenes for CDCA4 Gene

genes like me logo Genes that share paralogs with CDCA4: view

Variants for CDCA4 Gene

Sequence variations from dbSNP and Humsavar for CDCA4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000266643 -- 105,015,273(-) G/C intron_variant
rs1000340928 -- 105,015,686(-) T/C intron_variant
rs1000441134 -- 105,020,943(-) C/A intron_variant
rs1000500123 -- 105,020,393(-) A/G intron_variant
rs1000572531 -- 105,021,197(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA4 Gene

Variant ID Type Subtype PubMed ID
esv3349039 CNV insertion 20981092
esv3635634 CNV gain 21293372
nsv1042303 CNV gain 25217958
nsv1052190 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv1142856 CNV tandem duplication 24896259
nsv456458 CNV loss 19166990
nsv566141 CNV gain 21841781
nsv566150 CNV loss 21841781
nsv566151 CNV loss 21841781
nsv566152 CNV loss 21841781
nsv952276 CNV deletion 24416366

Variation tolerance for CDCA4 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDCA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA4 Gene

Disorders for CDCA4 Gene

Additional Disease Information for CDCA4

No disorders were found for CDCA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCA4 Gene

Publications for CDCA4 Gene

  1. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. (PMID: 16984923) Hayashi R … Yoshida K (The Journal of biological chemistry 2006) 3 4 22 58
  2. Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. (PMID: 11482882) Abdullah JM … Jurecic R (Blood cells, molecules & diseases 2001) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker MG (Current cancer drug targets 2001) 2 3 58

Products for CDCA4 Gene

Sources for CDCA4 Gene

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