CDCA4 Gene
protein-coding GIFtS: 46
GCID: GC14M105591
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cell division cycle associated 4
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Aliases
for CDCA4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cell Division Cycle Associated 41 2 | | Hepp1 | | HEPP2 3 5 | | SEI-3/HEPP2 | | Hematopoietic Progenitor Protein2 3 | | Cell Division Cycle-Associated Protein 42 | | FLJ207641 | | |
Export aliases for CDCA4 gene to outside databasesPrevious GC identifers: GC14M102854 GC14M099467 GC14M103447 GC14M104547 GC14M105557 GC14M105559 GC14M085669 GC14M105562 GC14M105567 GC14M105570 GC14M105576 |
Summaries
for CDCA4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDCA4:
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulatesE2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma proteinpathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitoticapparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as amidzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variantsencoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.(provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8Function: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved inmolecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (Bysimilarity)
|
Genomic Views
for CDCA4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDCA4 gene promoter:
Max1 NF-YA NF-YC CBF-C NF-YB CP1C CP1A LyF-1 NF-Y c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDCA4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33CDCA4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M105591: view genomic region
(about GC identifiers)
Start:
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105,475,910 bp from pter |
End:
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105,487,485 bp from pter |
Size:
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11,576 bases |
Orientation:
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minus strand |
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Proteins
for CDCA4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8 (See
protein sequence)Recommended Name: Cell division cycle-associated protein 4 Size: 241 amino acids; 26114 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA91373.1; Type=Erroneous initiation;
Secondary accessions: Q8TB18 Q9NWK7Explore the universe of human proteins at neXtProt for CDCA4: NX_Q9BXL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXL8
CDCA4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_060425.2 NP_663747.1
ENSEMBL proteins: ENSP00000337226 ENSP00000376369
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
CDCA4 for ontologies About GeneDecksing
CDCA4 Antibody Products:
Assay Products for CDCA4: |
Protein
Domains /
Families
for CDCA4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDCA4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXL8ProtoNet protein and cluster: Q9BXL8 1 Blocks protein family: IPB009263 SERTA
UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8Similarity: Contains 1 SERTA domain |
Function
for CDCA4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8Function: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved inmolecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (Bysimilarity)Induction: By E2F1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CDCA4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA4 |
1 GenomeRNAi human phenotype for CDCA4:
|
Pathways & Interactions
for CDCA4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDCA4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/13 Interacting proteins for CDCA4 (Q9BXL83 ENSP000003372264) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for CDCA4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDCA4 for compounds About GeneDecksing
 Browse Tocris compounds for CDCA4
1 Novoseek chemical compound relationship for CDCA4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepp |
93 |
5 |
16546331 (2), 11482882 (1), 16984923 (1) |
Search CenterWatch for drugs/clinical trials and news about CDCA4
|
Transcripts
for CDCA4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDCA4 gene (2 alternative transcripts): NM_017955.3 NM_145701.2 Unigene Cluster for CDCA4: Cell division cycle associated 4 Hs.34045 [show with all ESTs]Unigene Representative Sequence: NM_0179552 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336219(uc001yqa.2 uc001yqb.2) ENST00000392590
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CDCA4 (NM_145701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDCA4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA4 |
Additional cDNA sequence: AF322239.1 AK000771.1 AK303947.1 BC011736.2 BC025263.1 6 DOTS entries: DT.455026 DT.100794989 DT.100794991 DT.100658839 DT.100794990 DT.91765512 12 AceView cDNA sequences: CR620051 AK000771 CR607330 CR606097 CR594141 CR601657 CR605313 BC025263 NM_017955 NM_145701 BC011736 AF322239
GeneLoc Exon Structure
|
Expression
for CDCA4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDCA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTCTAA
About this image
See CDCA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDCA4
SOURCE GeneReport for Unigene cluster: Hs.34045
UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8Tissue specificity: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta andleukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable,if at all, in the brain, skeletal muscle and heart
SABiosciences Custom PCR Arrays for CDCA4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDCA4
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA4 |
Orthologs
for CDCA4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CDCA4 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for CDCA4 (if available)
TreeFam Gene Tree for CDCA4 (if available) |
Paralogs
for CDCA4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDCA4 gene
- SERTAD22
CDCA4 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for CDCA4
PGOHUM00000259467 PGOHUM00000245189 PGOHUM00000245191 PGOHUM00000236391
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Genomic Variants
for CDCA4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDCA4 (105475910 - 105487485 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDCA4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDCA4 |
|
Disorders
/ Diseases
for CDCA4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDCA4 for disorders About GeneDecksing
OMIM gene information: 612270
OMIM disorders: --
11  diseases for CDCA4: About MalaCardsstem cell leukemia herpes simplex retinoblastoma t-cell leukemia
hepatitis c neutropenia leukemia hepatitis
retinitis immunodeficiency prostatitis
1 Novoseek disease relationship for CDCA4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| herpes simplex |
57.1 |
3 |
10799875 (1), 8302016 (1), 15000871 (1) |
Export disorders for CDCA4 gene to outside databases
|
Publications
for CDCA4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDCA4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with CDCA4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. (PubMed id 16984923)1, 2, 9 Hayashi R....Yoshida K. (2006)
- Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. (PubMed id 11482882)1, 2, 9 Abdullah J.M.... Jurecic R. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 3 Walker M.G. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
- Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression. (PubMed id 18572021)1 Tategu M....Yoshida K. (2008)
- The spindle function of CDCA4. (PubMed id 18498124)1 Wang L....Zeng C. (2008)
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External Searches for CDCA4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDCA4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDCA4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDCA4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDCA4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDCA4 gene:
Search GeneIP for patents involving CDCA4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDCA4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDCA4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDCA4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDCA4 | | | OriGene Protein Over-expression Lysate for CDCA4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDCA4 | | OriGene 3'-UTR Clone for CDCA4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDCA4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDCA4 | | OriGene Custom Protein Services for CDCA4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDCA4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDCA4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCA4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCA4 |
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| | | | Search Tocris compounds for CDCA4 |
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 | | | CDCA4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA4 |
|  |  |  | | | | Search ThermoFisher Antibodies for CDCA4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA4 |
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