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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDCA4 Gene

protein-coding   GIFtS: 49
GCID: GC14M105598

Cell Division Cycle Associated 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle Associated 41 2
Hematopoietic Progenitor Protein1 2 3
HEPP2 3 5
SEI-3/HEPP2
Cell Division Cycle-Associated Protein 42

External Ids:    HGNC: 146251   Entrez Gene: 550382   Ensembl: ENSG000001707797   OMIM: 6122705   UniProtKB: Q9BXL83   

Export aliases for CDCA4 gene to outside databases

Previous GC identifers: GC14M102854 GC14M099467 GC14M103447 GC14M104547 GC14M105557 GC14M105559 GC14M085669 GC14M105562 GC14M105567 GC14M105570 GC14M105576 GC14M105591


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDCA4 Gene:
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates
E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein
pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive
nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also
play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced
transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been
identified on chromosome 1. (provided by RefSeq, Sep 2008)

GeneCards Summary for CDCA4 Gene: 
CDCA4 (cell division cycle associated 4) is a protein-coding gene. Diseases associated with CDCA4 include stem cell leukemia, and herpes simplex. An important paralog of this gene is SERTAD2.

UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8
Function: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in
molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDCA4 gene promoter:
         Max1   NF-YA   NF-YC   CBF-C   NF-YB   CP1C   CP1A   LyF-1   NF-Y   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDCA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

CDCA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105598:  view genomic region     (about GC identifiers)

Start:
105,475,910 bp from pter      End:
105,487,485 bp from pter
Size:
11,576 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8 (See protein sequence)
Recommended Name: Cell division cycle-associated protein 4  
Size: 241 amino acids; 26114 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA91373.1; Type=Erroneous initiation;
Secondary accessions: Q8TB18 Q9NWK7

Explore the universe of human proteins at neXtProt for CDCA4: NX_Q9BXL8

Explore proteomics data for CDCA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXL8

  • CDCA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDCA4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_060425.2  NP_663747.1  

    ENSEMBL proteins: 
     ENSP00000337226   ENSP00000376369  

    Human Recombinant Protein Products for CDCA4: 
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    Novus Biologicals CDCA4 Protein
    Novus Biologicals CDCA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDCA4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CDCA4 for ontologies           About GeneDecksing



    CDCA4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CDCA4 

    Assay Products for CDCA4: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CDCA4 
    Cloud-Clone Corp. CLIAs for CDCA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009263 SERTA

    Graphical View of Domain Structure for InterPro Entry Q9BXL8

    ProtoNet protein and cluster: Q9BXL8

    1 Blocks protein domain: IPB009263 SERTA

    UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8
    Similarity: Contains 1 SERTA domain


    CDCA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCA4_HUMAN, Q9BXL8
    Function: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in
    molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By
    similarity)
    Induction: By E2F1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CDCA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDCA4:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDCA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDCA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDCA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDCA4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDCA4:
    hsa-mir-107 (MIRT004690)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA4
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA4 (see all 21):
    hsa-miR-15a hsa-miR-503 hsa-miR-3653 hsa-miR-424 hsa-miR-499-5p hsa-miR-3658 hsa-miR-641 hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmidCDCA4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDCA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for CDCA4 (Q9BXL83 ENSP000003372264) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R2CQ9Y2T43, ENSP000003350834I2D: score=2 STRING: ENSP00000335083
    DOCK5Q9H7D03, ENSP000002764404I2D: score=1 STRING: ENSP00000276440
    TRIM28Q132633, ENSP000002530244I2D: score=1 STRING: ENSP00000253024
    PPP2R2BQ000053, ENSP000003365914I2D: score=2 STRING: ENSP00000336591
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDCA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDCA4

    1 Novoseek inferred chemical compound relationship for CDCA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepp 93 5 16546331 (2), 11482882 (1), 16984923 (1)

    Search CenterWatch for drugs/clinical trials and news about CDCA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDCA4 gene (2 alternative transcripts): 
    NM_017955.3  NM_145701.2  

    Unigene Cluster for CDCA4:

    Cell division cycle associated 4
    Hs.34045  [show with all ESTs]
    Unigene Representative Sequence: NM_017955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336219(uc001yqa.2 uc001yqb.2) ENST00000392590
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA4
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA4 (see all 21):
    hsa-miR-15a hsa-miR-503 hsa-miR-3653 hsa-miR-424 hsa-miR-499-5p hsa-miR-3658 hsa-miR-641 hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmidCDCA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCA4
    Clone
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    OriGene clones in human, mouse for CDCA4 (see all 15)
    OriGene ORF clones in mouse, rat for CDCA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDCA4 (NM_145701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA4
    Sirion Biotech Customized lentivirus for stable overexpression of CDCA4 
                         Customized lentivirus expression plasmids for stable overexpression of CDCA4 
    Primer
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    OriGene qPCR primer pairs and template standards for CDCA4
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDCA4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA4

    Additional mRNA sequence: 

    AF322239.1 AK000771.1 AK303947.1 BC011736.2 BC025263.1 

    6 DOTS entries:

    DT.455026  DT.100794989  DT.100794991  DT.100658839  DT.100794990  DT.91765512 

    12 AceView cDNA sequences:

    AK000771 CR620051 CR594141 CR605313 CR601657 CR606097 CR607330 BC025263 
    BC011736 NM_145701 NM_017955 AF322239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDCA4 expression in normal human tissues (normalized intensities)      CDCA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTCTAA
    CDCA4 Expression
    About this image


    CDCA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud

    See CDCA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDCA4

    SOURCE GeneReport for Unigene cluster: Hs.34045

    UniProtKB/Swiss-Prot: CDCA4_HUMAN, Q9BXL8
    Tissue specificity: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and
    leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly
    detectable, if at all, in the brain, skeletal muscle and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdca41 , 5 cell division cycle associated 41, 5 75.81(n)1
    74.26(a)1
      12 (61.20 cM)5
    719631  NM_028023.31  NP_082299.11 
     1128202375 
    chicken
    (Gallus gallus)
    Aves CDCA41 cell division cycle associated 4 65.56(n)
    64.17(a)
      423500  NM_001031212.2  NP_001026383.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDCA46
    --
    Uncharacterized protein
    60(a)
    24(a)
    1 ↔ 1
    possible ortholog
    1(3564627-3577779)
    1(3610480-3611334)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335312 Xenopus laevis transcribed sequences 72.88(n)    BU912363.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-177p2.71 si:dkey-177p2.7 56.72(n)
    52.94(a)
      494037  NM_001008580.1  NP_001008580.1 


    ENSEMBL Gene Tree for CDCA4 (if available)
    TreeFam Gene Tree for CDCA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDCA4 gene
    SERTAD22  

    CDCA4 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CDCA4
    PGOHUM00000259467 PGOHUM00000245189 PGOHUM00000245191 PGOHUM00000236391


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/350 SNPs in CDCA4 are shown (see all 350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562944321,2
    C--105475491(+) TTGAAC/TCTGGG 2 -- ds50010--------
    rs113195841,2
    C--105475577(+) AAAAA-/AAAACA 2 -- ds50010--------
    rs714544931,2
    C,F--105475589(+) AAAAC-/AAAAAA 2 -- ds50012Minor allele frequency- A:0.50NA CSA 4
    rs1128551181,2
    C,F--105475614(+) CACACG/AGACTA 2 -- ds50012Minor allele frequency- A:0.20CSA WA 120
    rs128921101,2
    C,F--105475679(+) CACGGT/CGGAAA 2 -- ds50019Minor allele frequency- C:0.36NA WA CSA EA 370
    rs1387590771,2
    --105475725(+) ACGGCG/TAGTCC 2 -- ds50010--------
    rs1403715041,2
    --105475746(+) ACTCCA/GGCTAC 2 -- ds50010--------
    rs1815796301,2
    --105475877(+) TGAAGG/TCTACC 2 -- ds50010--------
    rs285894171,2
    C,F--105475945(+) AATGCT/CATACA 2 -- ut313Minor allele frequency- C:0.33NA WA 6
    rs128926331,2
    C,F--105475991(+) ACACAT/CACCCT 2 -- ut319Minor allele frequency- C:0.37NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for CDCA4 (105475910 - 105487485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDCA4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902424CNV Loss21882294
    nsv456458CNV Loss19166990
    dgv2019n71CNV Loss21882294
    dgv2020n71CNV Loss21882294
    nsv902425CNV Loss21882294
    nsv902421CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDCA4
    DNA2.0 Custom Variant and Variant Library Synthesis for CDCA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612270    OMIM disorders: --

    11 diseases for CDCA4:    About MalaCards
    stem cell leukemia    herpes simplex    retinoblastoma    neutropenia
    t-cell leukemia    hepatitis c    retinitis    hepatitis
    leukemia    endotheliitis    prostatitis


    CDCA4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CDCA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 57.1 3 10799875 (1), 8302016 (1), 15000871 (1)


    Export disorders for CDCA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDCA4 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CDCA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. (PubMed id 16984923)1, 2, 9 Hayashi R....Yoshida K. (2006)
    2. Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. (PubMed id 11482882)1, 2, 9 Abdullah J.M.... Jurecic R. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 3 Walker M.G. (2001)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
    10. Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression. (PubMed id 18572021)1 Tategu M....Yoshida K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55038 HGNC: 14625 AceView: CDCA4 Ensembl:ENSG00000170779 euGenes: HUgn55038
    ECgene: CDCA4 H-InvDB: CDCA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDCA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDCA4 gene:
    Search GeneIP for patents involving CDCA4

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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