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Aliases for CDCA4 Gene

Aliases for CDCA4 Gene

  • Cell Division Cycle Associated 4 2 3
  • Hematopoietic Progenitor Protein 2 3 4
  • HEPP 3 4 6
  • Cell Division Cycle-Associated Protein 4 3
  • SEI-3/HEPP 3

External Ids for CDCA4 Gene

Summaries for CDCA4 Gene

Entrez Gene Summary for CDCA4 Gene

  • This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

GeneCards Summary for CDCA4 Gene

CDCA4 (Cell Division Cycle Associated 4) is a Protein Coding gene. Diseases associated with CDCA4 include herpes simplex. An important paralog of this gene is SERTAD2.

UniProtKB/Swiss-Prot for CDCA4 Gene

  • May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA4 Gene

Genomics for CDCA4 Gene

Genomic Location for CDCA4 Gene

Start:
105,009,573 bp from pter
End:
105,021,148 bp from pter
Size:
11,576 bases
Orientation:
Minus strand

Genomic View for CDCA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA4 Gene

Regulatory Elements for CDCA4 Gene

Proteins for CDCA4 Gene

  • Protein details for CDCA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXL8-CDCA4_HUMAN
    Recommended name:
    Cell division cycle-associated protein 4
    Protein Accession:
    Q9BXL8
    Secondary Accessions:
    • Q8TB18
    • Q9NWK7

    Protein attributes for CDCA4 Gene

    Size:
    241 amino acids
    Molecular mass:
    26114 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDCA4 Gene

Proteomics data for CDCA4 Gene at MOPED

Post-translational modifications for CDCA4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9

Other Protein References for CDCA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA4 Gene

Domains for CDCA4 Gene

Protein Domains for CDCA4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CDCA4_HUMAN
Domain:
  • Contains 1 SERTA domain.:
    • Q9BXL8
genes like me logo Genes that share domains with CDCA4: view

No data available for Gene Families for CDCA4 Gene

Function for CDCA4 Gene

Molecular function for CDCA4 Gene

UniProtKB/Swiss-Prot Function: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction: By E2F1.

Gene Ontology (GO) - Molecular Function for CDCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with CDCA4: view

Phenotypes for CDCA4 Gene

GenomeRNAi human phenotypes for CDCA4:
genes like me logo Genes that share phenotypes with CDCA4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDCA4 Gene

Localization for CDCA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA4 Gene COMPARTMENTS Subcellular localization image for CDCA4 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDCA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CDCA4: view

Pathways for CDCA4 Gene

SuperPathways for CDCA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDCA4 Gene

None

No data available for Pathways by source for CDCA4 Gene

Compounds for CDCA4 Gene

(1) Novoseek inferred chemical compound relationships for CDCA4 Gene

Compound -log(P) Hits PubMed IDs
hepp 93 4
genes like me logo Genes that share compounds with CDCA4: view

Transcripts for CDCA4 Gene

mRNA/cDNA for CDCA4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDCA4 Gene

Cell division cycle associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA4 Gene

No ASD Table

Relevant External Links for CDCA4 Gene

GeneLoc Exon Structure for
CDCA4
ECgene alternative splicing isoforms for
CDCA4

Expression for CDCA4 Gene

mRNA expression in normal human tissues for CDCA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDCA4 Gene

SOURCE GeneReport for Unigene cluster for CDCA4 Gene Hs.34045

mRNA Expression by UniProt/SwissProt for CDCA4 Gene

Q9BXL8-CDCA4_HUMAN
Tissue specificity: Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.
genes like me logo Genes that share expressions with CDCA4: view

Orthologs for CDCA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA4 36
  • 99.01 (n)
  • 99.5 (a)
CDCA4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA4 36
  • 74.36 (n)
  • 66.97 (a)
CDCA4 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA4 36
  • 78.28 (n)
  • 73.86 (a)
CDCA4 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca4 36
  • 75.81 (n)
  • 74.26 (a)
Cdca4 16
Cdca4 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA4 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA4 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca4 36
  • 75.25 (n)
  • 73.42 (a)
chicken
(Gallus gallus)
Aves CDCA4 36
  • 65.83 (n)
  • 65.69 (a)
CDCA4 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA4 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33531 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca4 36
  • 62.36 (n)
  • 58.75 (a)
zebrafish
(Danio rerio)
Actinopterygii CDCA4 37
  • 42 (a)
OneToOne
si:dkey-177p2.7 36
  • 56.72 (n)
  • 52.94 (a)
Species with no ortholog for CDCA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA4 Gene

ENSEMBL:
Gene Tree for CDCA4 (if available)
TreeFam:
Gene Tree for CDCA4 (if available)

Paralogs for CDCA4 Gene

Paralogs for CDCA4 Gene

Pseudogenes.org Pseudogenes for CDCA4 Gene

genes like me logo Genes that share paralogs with CDCA4: view

Variants for CDCA4 Gene

Sequence variations from dbSNP and Humsavar for CDCA4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1133629 -- 105,009,650(-) TATGT(A/G)TTTTA utr-variant-3-prime
rs3204172 -- 105,010,516(-) CAGGA(A/G)CCGCA utr-variant-3-prime
rs3204173 -- 105,010,321(-) CTCCC(A/G)TCAGG utr-variant-3-prime
rs3803294 -- 105,011,765(-) CCCAA(C/T)CTGTG reference, synonymous-codon
rs3923887 -- 105,014,172(+) GATCT(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA4 Gene

Variant ID Type Subtype PubMed ID
dgv2019n71 CNV Loss 21882294
nsv902421 CNV Loss 21882294
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294

Relevant External Links for CDCA4 Gene

HapMap Linkage Disequilibrium report
CDCA4

Disorders for CDCA4 Gene

(1) MalaCards Diseases for CDCA4 Gene

Search for CDCA4 Gene in MalaCards »

(1) Novoseek inferred disease relationships for CDCA4 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 57.1 3
genes like me logo Genes that share disorders with CDCA4: view

No data available for UniProtKB/Swiss-Prot for CDCA4 Gene

Publications for CDCA4 Gene

  1. Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. (PMID: 11482882) Abdullah J.M. … Jurecic R. (Blood Cells Mol. Dis. 2001) 3 4 23
  2. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. (PMID: 16984923) Hayashi R. … Yoshida K. (J. Biol. Chem. 2006) 3 4 23
  3. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CDCA4 Gene

Sources for CDCA4 Gene

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