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Aliases for CDCA2 Gene

Aliases for CDCA2 Gene

  • Cell Division Cycle Associated 2 2 3
  • Recruits PP1 Onto Mitotic Chromatin At Anaphase Protein 3 4
  • Repo-Man 3 4
  • Protein Phosphatase 1 [Gamma] (PPP1R3A) Binding Protein Repo-Man 3
  • Protein Phosphatase 1, Regulatory Subunit 81 3
  • Cell Division Cycle-Associated Protein 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 81 2
  • PPP1R81 3

External Ids for CDCA2 Gene

Previous GeneCards Identifiers for CDCA2 Gene

  • GC08U990159
  • GC08P025137
  • GC08P025338
  • GC08P025372
  • GC08P023861
  • GC08P025316

Summaries for CDCA2 Gene

GeneCards Summary for CDCA2 Gene

CDCA2 (Cell Division Cycle Associated 2) is a Protein Coding gene. Diseases associated with CDCA2 include dermatophytosis.

UniProtKB/Swiss-Prot for CDCA2 Gene

  • Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA2 Gene

Genomics for CDCA2 Gene

Regulatory Elements for CDCA2 Gene

Genomic Location for CDCA2 Gene

Start:
25,458,759 bp from pter
End:
25,507,920 bp from pter
Size:
49,162 bases
Orientation:
Plus strand

Genomic View for CDCA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA2 Gene

Proteins for CDCA2 Gene

  • Protein details for CDCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YH5-CDCA2_HUMAN
    Recommended name:
    Cell division cycle-associated protein 2
    Protein Accession:
    Q69YH5
    Secondary Accessions:
    • Q3SX74
    • Q4G0W0
    • Q5RKN0
    • Q69YI4
    • Q6P464
    • Q8N7C1

    Protein attributes for CDCA2 Gene

    Size:
    1023 amino acids
    Molecular mass:
    112676 Da
    Quaternary structure:
    • Interacts with PPP1CC.
    SequenceCaution:
    • Sequence=AAH36214.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05374.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10577.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA2 Gene

Proteomics data for CDCA2 Gene at MOPED

Post-translational modifications for CDCA2 Gene

Other Protein References for CDCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA2 Gene

Domains for CDCA2 Gene

Protein Domains for CDCA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDCA2 Gene

Function for CDCA2 Gene

Molecular function for CDCA2 Gene

UniProtKB/Swiss-Prot Function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

Phenotypes for CDCA2 Gene

genes like me logo Genes that share phenotypes with CDCA2: view

miRNA for CDCA2 Gene

miRTarBase miRNAs that target CDCA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDCA2 Gene

Localization for CDCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA2 Gene

Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA2 Gene COMPARTMENTS Subcellular localization image for CDCA2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CDCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IDA 22801782
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDCA2: view

Pathways for CDCA2 Gene

SuperPathways for CDCA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0035307 positive regulation of protein dephosphorylation IMP 22801782
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA2: view

No data available for Pathways by source for CDCA2 Gene

Transcripts for CDCA2 Gene

Unigene Clusters for CDCA2 Gene

Cell division cycle associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ·
SP1:
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:

ExUns: 15c ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:

Relevant External Links for CDCA2 Gene

GeneLoc Exon Structure for
CDCA2
ECgene alternative splicing isoforms for
CDCA2

Expression for CDCA2 Gene

mRNA expression in normal human tissues for CDCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA2 Gene

This gene is overexpressed in Testis (15.3) and Heart - Left Ventricle (5.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CDCA2 Gene

SOURCE GeneReport for Unigene cluster for CDCA2 Gene Hs.33366

mRNA Expression by UniProt/SwissProt for CDCA2 Gene

Q69YH5-CDCA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CDCA2: view

Orthologs for CDCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA2 35
  • 99.28 (n)
  • 98.73 (a)
CDCA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
CDCA2 35
  • 75.32 (n)
  • 62.22 (a)
dog
(Canis familiaris)
Mammalia CDCA2 35
  • 77.85 (n)
  • 65.35 (a)
CDCA2 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca2 35
  • 68.81 (n)
  • 54.93 (a)
Cdca2 16
Cdca2 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA2 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA2 36
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca2 35
  • 69.36 (n)
  • 55.23 (a)
chicken
(Gallus gallus)
Aves CDCA2 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA2 36
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CDCA2 36
  • 22 (a)
OneToOne
Species with no ortholog for CDCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA2 Gene

ENSEMBL:
Gene Tree for CDCA2 (if available)
TreeFam:
Gene Tree for CDCA2 (if available)

Paralogs for CDCA2 Gene

No data available for Paralogs for CDCA2 Gene

Variants for CDCA2 Gene

Sequence variations from dbSNP and Humsavar for CDCA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8537 -- 25,507,762(+) TCTGT(A/G)GCAAG utr-variant-3-prime
rs14464 -- 25,507,717(-) CCATT(A/G)TGTTC synonymous-codon, reference
rs955839 -- 25,506,191(+) TGCCT(C/T)ATACT intron-variant
rs1532914 -- 25,478,886(-) ataca(C/T)aCACA intron-variant
rs1532915 -- 25,478,795(-) TACTG(C/T)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA2 Gene

Variant ID Type Subtype PubMed ID
nsv890689 CNV Gain 21882294
essv1351 CNV CNV 17122850
esv2736777 CNV Deletion 23290073
esv2307416 CNV Deletion 18987734
esv2736778 CNV Deletion 23290073
esv999925 CNV Deletion 20482838
esv1305754 CNV Deletion 17803354
nsv396689 CNV Loss 16902084
esv259811 OTHER Complex 20981092
nsv819420 CNV Loss 19587683

Relevant External Links for CDCA2 Gene

HapMap Linkage Disequilibrium report
CDCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA2 Gene

Disorders for CDCA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDCA2 Gene including...

Search for CDCA2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDCA2 Gene

Relevant External Links for CDCA2

Genetic Association Database (GAD)
CDCA2
Human Genome Epidemiology (HuGE) Navigator
CDCA2
genes like me logo Genes that share disorders with CDCA2: view

No data available for UniProtKB/Swiss-Prot for CDCA2 Gene

Publications for CDCA2 Gene

  1. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. (PMID: 16492807) Trinkle-Mulcahy L. … Lamond A.I. (J. Cell Biol. 2006) 2 3 4
  2. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. (PMID: 16998479) Vagnarelli P. … Earnshaw W.C. (Nat. Cell Biol. 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CDCA2 Gene

  • Addgene plasmids for CDCA2

Sources for CDCA2 Gene

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