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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDCA2 Gene

protein-coding   GIFtS: 49
GCID: GC08P025316

cell division cycle associated 2
 Explore 3 diseases affiliated with
CDCA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDCA2    

Aliases
for CDCA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle Associated 21 2
Repo-Man1 2 3
Recruits PP1 Onto Mitotic Chromatin At Anaphase Protein2 3
Cell Division Cycle-Associated Protein 22
Protein Phosphatase 1 [Gamma] (PPP1R3A) Binding Protein Repo-Man2

External Ids:    HGNC: 146231   Entrez Gene: 1573132   Ensembl: ENSG000001846617   UniProtKB: Q69YH53   

Export aliases for CDCA2 gene to outside databases

Previous GC identifers: GC08U990159 GC08P025137 GC08P025338 GC08P025372 GC08P023861


Summaries
for CDCA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CDCA2_HUMAN, Q69YH5
Function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their
compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to
chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a
pool of PPP1CC to dephosphorylate substrates




Genomic Views
for CDCA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDCA2 gene promoter:
         TBP   GR   Sp1   AP-1   ATF-2   GR-beta   CREB   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDCA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDCA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

CDCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P025316:  view genomic region     (about GC identifiers)

Start:
 25,316,513 bp from pter      End:
 25,365,436 bp from pter
Size:
 48,924 bases      Orientation:
 plus strand

Proteins
for CDCA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDCA2_HUMAN, Q69YH5 (See protein sequence)
Recommended Name: Cell division cycle-associated protein 2  
Size: 1023 amino acids; 112676 Da
Subunit: Interacts with PPP1CC
Subcellular location: Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2
stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down,
and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin
Sequence caution: Sequence=AAH36214.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC05374.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH10577.1;
Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q3SX74 Q4G0W0 Q5RKN0 Q69YI4 Q6P464 Q8N7C1
Alternative splicing: 2 isoforms:  Q69YH5-1   Q69YH5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDCA2: NX_Q69YH5

Post-translational modifications:

  • Phosphorylated by CDK1. May regulate its subcellular location1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q69YH5

    • CDCA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689775.2  
    ENSEMBL proteins: 
     ENSP00000328228   ENSP00000370040  

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    Novus Biologicals CDCA2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDCA2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    CDCA2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CDCA2

    Protein Domains /
    Families
    for CDCA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDCA2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026149 Cdca2

    Graphical View of Domain Structure for InterPro Entry Q69YH5

    ProtoNet protein and cluster: Q69YH5


    Function
    for CDCA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDCA2_HUMAN, Q69YH5
    Function: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their
    compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to
    chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a
    pool of PPP1CC to dephosphorylate substrates

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CDCA2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA2

    1 GenomeRNAi human phenotype for CDCA2:
     Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for CDCA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDCA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for CDCA2 (Q69YH52, 3 ENSP000003282284) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBD4O952432, 3, ENSP000002499104MINT-8262891 I2D: score=2 STRING: ENSP00000249910
    CDK1P064933I2D: score=1 
    RB1CC1Q8TDY23I2D: score=1 
    JMJD6ENSP000003940854STRING: ENSP00000394085
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0051301cell division IEA--


    CDCA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDCA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDCA2
    Search CenterWatch for drugs/clinical trials and news about CDCA2 

    Transcripts
    for CDCA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDCA2 gene: 
    NM_152562.2  

    Unigene Cluster for CDCA2:

    Cell division cycle associated 2
    Hs.33366  [show with all ESTs]
    Unigene Representative Sequence: NM_152562
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330560(uc003xep.1 uc011lae.1 uc003xeq.1 uc003xer.1)
    ENST00000518225 ENST00000380665 ENST00000519087 ENST00000523454 ENST00000521098


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    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA2

    Additional cDNA sequence: 

    AK092164.1 AK098670.1 AK292505.1 AK299278.1 AL833396.1 AL833627.1 BC015691.2 BC036214.1 
    BC063651.1 BC085609.1 BC104450.1 BC104451.1 BX649008.1 

    6 DOTS entries:

    DT.414350  DT.100747109  DT.101981664  DT.121486990  DT.100734777  DT.100747110 

    24/106 AceView cDNA sequences (see all 106):

    AA706962 AA780179 AA770066 CF528734 BF516303 CK724907 AA554918 AA706943 
    AL833396 AA330145 AL833627 AW294271 AA815224 NM_152562 AA682508 AA278504 
    BQ017718 AA252616 BM459084 AA860093 CF142325 BU754019 AA332424 AX747387 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ·
    SP1:                                                                                                                                                            
    SP2:                                                                                            -                                                               
    SP3:                                -                                                                                                                           
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 15c ^ 16
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CDCA2

    Expression
    for CDCA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDCA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTATTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDCA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See CDCA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDCA2

    SOURCE GeneReport for Unigene cluster: Hs.33366

    UniProtKB/Swiss-Prot: CDCA2_HUMAN, Q69YH5
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for CDCA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdca21 , 5 cell division cycle associated 21, 5 68.88(n)1
    54.93(a)1    		   14 (34.66 cM)5
    1089121  NM_001110162.11  NP_001103632.11 
     676763315 
    chicken
    (Gallus gallus)    		 Aves CDCA26
    		 Uncharacterized protein
    		 30(a)
    		 1 ↔ 1
    		 22(819587-824834)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-244o22.21 si:ch211-244o22.2 39.87(n)
    26.17(a)    		   561487  NM_001082823.2  NP_001076292.1 


    ENSEMBL Gene Tree for CDCA2 (if available)
    TreeFam Gene Tree for CDCA2 (if available) 

    Paralogs
    for CDCA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CDCA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/924 NCBI SNPs in CDCA2 are shown (see all 924)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1158758641,2
    		C,F,--25317987(+) AGATAC/TTTTTA 2 T I mis13Minor allele frequency- T:0.02WA NA EU 5991
    rs115591341,2
    		H--25317996(+) TAAATC/TACCTT 2 S L mis1 ese34Minor allele frequency- T:0.00NS EA 406
    rs1160864381,2
    		C,F,--25318021(+) GTAACC/G/TGTAGA 3 T syn11WA 216
    rs1166325861,2
    		C,F,--25318022(+) TAACCG/ATAGAG 2 /I /V mis11Minor allele frequency- A:0.01WA 216
    rs1830745621,2
    		--25318157(+) GTACTG/TTCATA 1 -- int10--------
    rs786971641,2
    		F,--25318184(+) TGCCTA/GCTCTG 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1481468791,2
    		--25318185(+) GCCTAC/GTCTGC 1 -- int10--------
    rs1419989081,2
    		--25318187(+) CTACTC/TTGCAA 1 -- int10--------
    rs170537431,2
    		C,F,H,--25318253(+) GGATCA/GCGGAA 1 -- int122Minor allele frequency- G:0.27NA NS EA CSA WA 2294
    rs736773251,2
    		C,--25318254(+) GATCAC/GGGAAT 1 -- int12Minor allele frequency- G:0.09WA 120

    HapMap Linkage Disequilibrium report for CDCA2 (25316513 - 25365436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CDCA2
         1 CNV: 3727
         1 Indel: 59465

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDCA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDCA2

    Disorders / Diseases
    for CDCA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDCA2 for disorders           About GeneDecksing

    3 diseases for CDCA2:    About MalaCards
    dermatophytosis    folliculitis    fainting

    1 disease from the University of Copenhagen DISEASES database for CDCA2:
    Dermatophytosis
    Human Genome Epidemiology (HuGE) Navigator: CDCA2 (1 document)

    Export disorders for CDCA2 gene to outside databases

    Publications
    for CDCA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDCA2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CDCA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. (PubMed id 16492807)1, 2, 3 Trinkle-Mulcahy L....Lamond A.I. (2006)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (2001)
    3. Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. (PubMed id 16998479)1, 2 Vagnarelli P.... Earnshaw W.C. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. (PubMed id 22801782)1 Wurzenberger C....Gerlich D.W. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. (PubMed id 21820363)1 Vagnarelli P....Earnshaw W.C. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    External Searches for CDCA2 gene

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    Genome Databases showing CDCA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157313 HGNC: 14623 AceView: CDCA2 Ensembl:ENSG00000184661 euGenes: HUgn157313
    ECgene: CDCA2 H-InvDB: CDCA2

    Other Databases showing CDCA2 gene

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    Specialized Databases showing CDCA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for CDCA2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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