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Aliases for CDCA2 Gene

Aliases for CDCA2 Gene

  • Cell Division Cycle Associated 2 2 3 5
  • Recruits PP1 Onto Mitotic Chromatin At Anaphase Protein 3 4
  • Repo-Man 3 4
  • Protein Phosphatase 1, Regulatory Subunit 81 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 81 2
  • PPP1R81 3

External Ids for CDCA2 Gene

Previous GeneCards Identifiers for CDCA2 Gene

  • GC08U990159
  • GC08P025137
  • GC08P025338
  • GC08P025372
  • GC08P023861
  • GC08P025316

Summaries for CDCA2 Gene

Entrez Gene Summary for CDCA2 Gene

  • This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for CDCA2 Gene

CDCA2 (Cell Division Cycle Associated 2) is a Protein Coding gene. Among its related pathways are DNA Damage.

UniProtKB/Swiss-Prot for CDCA2 Gene

  • Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA2 Gene

Genomics for CDCA2 Gene

Regulatory Elements for CDCA2 Gene

Enhancers for CDCA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDCA2 on UCSC Golden Path with GeneCards custom track

Promoters for CDCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDCA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDCA2 Gene

Chromosome:
8
Start:
25,458,574 bp from pter
End:
25,511,308 bp from pter
Size:
52,735 bases
Orientation:
Plus strand

Genomic View for CDCA2 Gene

Genes around CDCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA2 Gene

Proteins for CDCA2 Gene

  • Protein details for CDCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YH5-CDCA2_HUMAN
    Recommended name:
    Cell division cycle-associated protein 2
    Protein Accession:
    Q69YH5
    Secondary Accessions:
    • Q3SX74
    • Q4G0W0
    • Q5RKN0
    • Q69YI4
    • Q6P464
    • Q8N7C1

    Protein attributes for CDCA2 Gene

    Size:
    1023 amino acids
    Molecular mass:
    112676 Da
    Quaternary structure:
    • Interacts with PPP1CC.
    SequenceCaution:
    • Sequence=AAH36214.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05374.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10577.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA2 Gene

Proteomics data for CDCA2 Gene at MOPED

Post-translational modifications for CDCA2 Gene

Other Protein References for CDCA2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDCA2 (CDCA2)
  • Abcam antibodies for CDCA2

No data available for DME Specific Peptides for CDCA2 Gene

Domains & Families for CDCA2 Gene

Gene Families for CDCA2 Gene

Protein Domains for CDCA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA2: view

No data available for UniProtKB/Swiss-Prot for CDCA2 Gene

Function for CDCA2 Gene

Molecular function for CDCA2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
genes like me logo Genes that share phenotypes with CDCA2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA2 Gene

Localization for CDCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA2 Gene

Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA2 Gene COMPARTMENTS Subcellular localization image for CDCA2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDCA2: view

Pathways & Interactions for CDCA2 Gene

SuperPathways for CDCA2 Gene

Superpath Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with CDCA2: view

Pathways by source for CDCA2 Gene

1 Cell Signaling Technology pathway for CDCA2 Gene

Gene Ontology (GO) - Biological Process for CDCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA2: view

No data available for SIGNOR curated interactions for CDCA2 Gene

Drugs & Compounds for CDCA2 Gene

No Compound Related Data Available

Transcripts for CDCA2 Gene

Unigene Clusters for CDCA2 Gene

Cell division cycle associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ·
SP1:
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:

ExUns: 15c ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:

Relevant External Links for CDCA2 Gene

GeneLoc Exon Structure for
CDCA2
ECgene alternative splicing isoforms for
CDCA2

Expression for CDCA2 Gene

mRNA expression in normal human tissues for CDCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA2 Gene

This gene is overexpressed in Testis (x15.3) and Heart - Left Ventricle (x5.2).

Protein differential expression in normal tissues from HIPED for CDCA2 Gene

This gene is overexpressed in Plasma (56.0) and Monocytes (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDCA2 Gene



SOURCE GeneReport for Unigene cluster for CDCA2 Gene Hs.33366

mRNA Expression by UniProt/SwissProt for CDCA2 Gene

Q69YH5-CDCA2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CDCA2: view

Protein tissue co-expression partners for CDCA2 Gene

Primer Products

Orthologs for CDCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDCA2 35
  • 75.32 (n)
  • 62.22 (a)
-- 36
  • 46 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDCA2 35
  • 77.85 (n)
  • 65.35 (a)
CDCA2 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca2 35
  • 68.81 (n)
  • 54.93 (a)
Cdca2 16
Cdca2 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDCA2 35
  • 99.28 (n)
  • 98.73 (a)
CDCA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca2 35
  • 69.36 (n)
  • 55.23 (a)
oppossum
(Monodelphis domestica)
Mammalia CDCA2 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA2 36
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA2 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA2 36
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CDCA2 36
  • 22 (a)
OneToOne
Species with no ortholog for CDCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA2 Gene

ENSEMBL:
Gene Tree for CDCA2 (if available)
TreeFam:
Gene Tree for CDCA2 (if available)

Paralogs for CDCA2 Gene

No data available for Paralogs for CDCA2 Gene

Variants for CDCA2 Gene

Sequence variations from dbSNP and Humsavar for CDCA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4872318 - 25,506,815(+) CTTCT(A/G)TAACT nc-transcript-variant, reference, missense, utr-variant-3-prime
rs3829009 - 25,507,318(+) AGGAG(A/T)AATAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs2135627 -- 25,492,885(-) CTCTT(A/G)CCAGC intron-variant
rs2174687 -- 25,492,656(-) TCCTC(C/T)GGGCC intron-variant
rs2271103 -- 25,486,174(-) TAAGA(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA2 Gene

Variant ID Type Subtype PubMed ID
nsv890689 CNV Gain 21882294
essv1351 CNV CNV 17122850
esv2736777 CNV Deletion 23290073
esv2307416 CNV Deletion 18987734
esv2736778 CNV Deletion 23290073
esv999925 CNV Deletion 20482838
esv1305754 CNV Deletion 17803354
nsv396689 CNV Loss 16902084
esv259811 OTHER Complex 20981092
nsv819420 CNV Loss 19587683

Variation tolerance for CDCA2 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.90; 83.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDCA2 Gene

Disorders for CDCA2 Gene

Relevant External Links for CDCA2

Genetic Association Database (GAD)
CDCA2
Human Genome Epidemiology (HuGE) Navigator
CDCA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA2

No disorders were found for CDCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCA2 Gene

Publications for CDCA2 Gene

  1. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. (PMID: 16492807) Trinkle-Mulcahy L. … Lamond A.I. (J. Cell Biol. 2006) 2 3 4 67
  2. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CDCA2 Gene

Sources for CDCA2 Gene

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