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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC7 Gene

protein-coding   GIFtS: 68
GCID: GC01P091966

Cell Division Cycle 7

(Previous names: CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like...)
(Previous symbol: CDC7L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 71 2     Hsk12
CDC7L11 2 3 5     Cell Division Cycle 7 Homolog2
CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 11 2     Cell Division Cycle 7-Like Protein 12
CDC7-Related Kinase2 3     Cell Division Cycle 7-Related Protein Kinase2
CDC7 Cell Division Cycle 7 (S. Cerevisiae)1     huCDC72
Cell Division Cycle 7 (S. Cerevisiae)1     EC 2.7.11.13
Cell Division Cycle 7 Homolog (S. Cerevisiae)1     HsCdc73
HsCDC72     huCdc73

External Ids:    HGNC: 17451   Entrez Gene: 83172   Ensembl: ENSG000000970467   OMIM: 6033115   UniProtKB: O003113   

Export aliases for CDC7 gene to outside databases

Previous GC identifers: GC01P091303 GC01P091438 GC01P091678 GC01P091739 GC01P090085


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC7 Gene:
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The
yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this
gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced
transcript variants that encode the same protein have been detected. (provided by RefSeq, Aug 2008)

GeneCards Summary for CDC7 Gene: 
CDC7 (cell division cycle 7) is a protein-coding gene. Diseases associated with CDC7 include ataxia telangiectasia, and ataxia, and among its related super-pathways are Activation of the pre-replicative complex and Cell cycle. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity.

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311
Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA
replication. Can phosphorylates MCM2 and MCM3

Gene Wiki entry for CDC7 (Cell division cycle 7-related protein kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC7 gene promoter:
         GR   AML1a   Pax-6   GR-alpha   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22

CDC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P091966:  view genomic region     (about GC identifiers)

Start:
91,966,404 bp from pter      End:
91,991,321 bp from pter
Size:
24,918 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311 (See protein sequence)
Recommended Name: Cell division cycle 7-related protein kinase  
Size: 574 amino acids; 63888 Da
Cofactor: Magnesium
Subunit: Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity
Subcellular location: Nucleus
4 PDB 3D structures from and Proteopedia for CDC7:
4F99 (3D)        4F9A (3D)        4F9B (3D)        4F9C (3D)    
Secondary accessions: D3DT31 O00558 Q5T5U5
Alternative splicing: 1 isoform:  O00311-1   

Explore the universe of human proteins at neXtProt for CDC7: NX_O00311

Explore proteomics data for CDC7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00311

  • CDC7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001127891.1  NP_001127892.1  NP_003494.1  

    ENSEMBL proteins: 
     ENSP00000234626   ENSP00000398077   ENSP00000407477   ENSP00000393139  
    Reactome Protein details: O00311
    Human Recombinant Protein Products for CDC7: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDC7
    OriGene Custom MassSpec 
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    Novus Biologicals CDC7 Protein
    Novus Biologicals CDC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9250678
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA9250678

    CDC7 for ontologies           About GeneDecksing



    CDC7 Antibody Products: 
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    Novus Biologicals CDC7 Antibodies
    Abcam antibodies for CDC7
    Cloud-Clone Corp. Antibodies for CDC7 
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    LSBio Antibodies in human, mouse, rat for CDC7 

    Assay Products for CDC7: 
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    GenScript Custom Assay Services for CDC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC7 
    Cloud-Clone Corp. CLIAs for CDC7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: cell division cycle 7 homolog (S. cerevisiae) 
    CDC7 family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O00311

    ProtoNet protein and cluster: O00311

    UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily
    Similarity: Contains 1 protein kinase domain


    CDC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC7_HUMAN, O00311
    Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA
    replication. Can phosphorylates MCM2 and MCM3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity IDA9250678
         
    CDC7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDC7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with RAF26  Paclitaxel antagonistic effect 
     Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdc7):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  normal  reproductive system 

    CDC7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdc7tm1Hmas for CDC7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDC7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC7:
    hsa-mir-192 (MIRT004845)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC7
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC7 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCDC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC7 (NM_003503)
    Sino Biological Human cDNA Clone for CDC7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC7
    Sirion Biotech Customized lentivirus for stable overexpression of CDC7 
                         Customized lentivirus expression plasmids for stable overexpression of CDC7 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDC7
    Search LifeMap BioReagents cell lines for CDC7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC7 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    M/G1 Transition0.81
    DNA Replication0.78
    DNA Replication Pre-Initiation0.81
    Cell Cycle Checkpoints0.58
    4Activation of ATR in response to replication stress
    G2/M Checkpoints0.86
    Activation of ATR in response to replication stress0.86
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CDC7
        Meiosis
    Cell cycle Start of DNA replication in early S phase


    1 Cell Signaling Technology (CST) Pathway for CDC7
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDC7
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for CDC7
        Cell cycle
    DNA Replication


    5/12        Reactome Pathways for CDC7 (see all 12)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    Cell Cycle
    M/G1 Transition


    1         Kegg Pathway  (Kegg details for CDC7):
        Cell cycle


    CDC7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for CDC7 (O003112, 3 ENSP000002346264) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006468protein phosphorylation ----
    GO:0008284positive regulation of cell proliferation IMP17102137

    CDC7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC7 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDC7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CDC7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DIMActivates Chk2; induces G2/M cell cycle arrest[1968-05-4]
    Compound 401Selective DNA-PK and mTOR inhibitor[168425-64-7]
    MirinMRN-ATM pathway inhibitor[1198097-97-0]
    PHA 767491 hydrochlorideDual cdc7/cdk9 inhibitor. Also inhibits MK2[942425-68-5]
    PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 [212391-63-4]

    2 HMDB Compounds for CDC7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for CDC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 51.5 10 10846177 (2), 17046832 (1), 18714392 (1), 11250080 (1) (see all 7)
    serine 38.5 6 17046832 (1), 18714392 (1), 11441535 (1), 16864800 (1) (see all 6)
    caffeine 16.4 1 15220931 (1)
    alanine 13 3 17046832 (1), 16864800 (1), 10846177 (1)

    Search CenterWatch for drugs/clinical trials and news about CDC7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC7 gene (3 alternative transcripts): 
    NM_001134419.1  NM_001134420.1  NM_003503.3  

    Unigene Cluster for CDC7:

    Cell division cycle 7
    Hs.533573  [show with all ESTs]
    Unigene Representative Sequence: AB209337
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234626(uc001doe.3 uc001dof.3 uc010osw.2 uc009wdd.3)
    ENST00000426137 ENST00000497611 ENST00000486509 ENST00000430031 ENST00000428239(uc009wdc.3)


    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC7 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCDC7 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC7
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC7

    Additional mRNA sequence: 

    AB003698.1 AB209337.1 AF005209.1 AF015592.1 AK298963.1 AK312726.1 AY312583.1 BC110526.1 
    BC110527.1 BC111044.1 

    9 DOTS entries:

    DT.314780  DT.92037489  DT.100812839  DT.99972354  DT.75164847  DT.121342092  DT.95364370  DT.97819446 
    DT.95124348 

    24/92 AceView cDNA sequences (see all 92):

    AA429583 AL602215 NM_003503 N79336 AA291015 D20593 BM789148 BG170872 
    AY312583 AU120443 AW574512 BE855770 AI435106 BU567384 BF793010 CA441701 
    CN483945 BX103240 BF432510 BQ221549 AU116849 AU129167 W73020 CD642993 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDC7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:                                                              -           -                                 
    SP2:                                            -                 -           -                                 
    SP3:                                                              -           -     -                           
    SP4:                                                                          -                                 
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CDC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC7 expression in normal human tissues (normalized intensities)      CDC7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCATTTT
    CDC7 Expression
    About this image


    CDC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             ganglion/cranial/facial VII   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   

    See CDC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC7

    SOURCE GeneReport for Unigene cluster: Hs.533573
        SABiosciences Custom PCR Arrays for CDC7
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC7 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc71 , 5 cell division cycle 7 (S. cerevisiae)1, 5 83.21(n)1
    81.43(a)1
      5 (51.43 cM)5
    125451  NM_009863.21  NP_033993.21 
     1069643225 
    chicken
    (Gallus gallus)
    Aves CDC71 cell division cycle 7 homolog (S. cerevisiae) 73.99(n)
    69.6(a)
      424507  XM_422347.3  XP_422347.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDC76
    cell division cycle 7
    64(a)
    1 ↔ 1
    4(94514181-94540170)
    African clawed frog
    (Xenopus laevis)
    Amphibia Cdc72 protein kinase Cdc7 76.41(n)    AF080068.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203622 Transcribed sequence with weak similarity to protein more 74.9(n)    57054035 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G01481 lethal (1) G0148 45.37(n)
    39.59(a)
      31598  NM_167080.1  NP_727103.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-76
    Protein CDC-7
    26(a)
    1 ↔ 1
    I(5872174-5874342)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC7(YDL017W)4 DDK (Dbf4-dependent kinase) catalytic subunit required more   --   4(424209-425732) 851545  NP_010267.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G169701 cell division control protein 7 41.32(n)
    30.7(a)
      827405  NM_117800.3  NP_193430.3 


    ENSEMBL Gene Tree for CDC7 (if available)
    TreeFam Gene Tree for CDC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/610 SNPs in CDC7 are shown (see all 610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898011791,2
    --91964407(+) ATATCA/GTATAG 2 -- us2k10--------
    rs1828277421,2
    --91964431(+) TTCATC/TTATAA 2 -- us2k10--------
    rs1468274341,2
    --91964547(+) GTTAAC/TGACCT 2 -- us2k10--------
    rs1869878121,2
    C--91964605(+) GTATTG/TCTTGT 2 -- us2k10--------
    rs1392400211,2
    --91964883(+) TAGGAG/TAAGGA 3 -- us2k10--------
    rs1433560501,2
    --91964919(+) GGCAAA/TGTTGA 3 -- us2k10--------
    rs127177981,2
    C,F--91964946(+) acataT/Cgatta 3 -- us2k16Minor allele frequency- C:0.20NS NA EA 424
    rs134474481,2
    C,F--91964947(+) CATATG/AATTAT 3 -- us2k12Minor allele frequency- A:0.04NS NA 300
    rs127177991,2
    C,F,H--91964984(+) tatcaC/Tggtca 3 -- us2k18Minor allele frequency- T:0.02NS EA NA 724
    rs5654511,2
    C,F,A,H--91965131(-) aaagcG/Agacct 3 -- us2k123Minor allele frequency- A:0.13NS EA NA WA CSA 1327

    HapMap Linkage Disequilibrium report for CDC7 (91966404 - 91991321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDC7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    esv2452061CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC7
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603311    OMIM disorders: --

    9 diseases for CDC7:    About MalaCards
    ataxia telangiectasia    ataxia    glaucoma    alzheimer's disease
    melanoma    prostate cancer    prostatitis    breast cancer
    neuronitis


    CDC7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for CDC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 39.6 2 16446360 (2)
    cancer 2.98 7 18714392 (1), 17062569 (1), 19115845 (1), 15466207 (1) (see all 6)
    tumors 2.83 13 18714392 (2), 19318489 (2), 19278428 (1), 15466207 (1) (see all 5)

    Genetic Association Database (GAD): CDC7
    Human Genome Epidemiology (HuGE) Navigator: CDC7 (3 documents)

    Export disorders for CDC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC7 gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with CDC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PubMed id 9250678)1, 2, 3, 9 Sato N....Masai H. (1997)
    2. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PubMed id 9405610)1, 2, 3, 9 Jiang W. and Hunter T. (1997)
    3. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PubMed id 10373557)1, 2, 9 Kumagai H.... Masai H. (1999)
    4. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PubMed id 17062569)1, 2, 9 Tenca P....Santocanale C. (2007)
    5. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PubMed id 15668232)1, 2, 9 Yoshizawa-Sugata N....Masai H. (2005)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Drf1, a novel regulatory subunit for human Cdc7 kinase. (PubMed id 12065429)1, 2 Montagnoli A.... Santocanale C. (2002)
    10. A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. (PubMed id 9573348)1, 2 Hess G.F....Hollingsworth R.E. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8317 HGNC: 1745 AceView: CDC7 Ensembl:ENSG00000097046 euGenes: HUgn8317
    ECgene: CDC7 Kegg: 8317 H-InvDB: CDC7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC7 gene:
    Search GeneIP for patents involving CDC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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