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Aliases for CDC7 Gene

Aliases for CDC7 Gene

  • Cell Division Cycle 7 2 3 5
  • CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1 2 3
  • CDC7-Related Kinase 3 4
  • HsCDC7 3 4
  • HuCDC7 3 4
  • CDC7L1 3 4
  • Cell Division Cycle 7 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 7-Related Protein Kinase 3
  • CDC7 Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7-Like Protein 1 3
  • Cell Division Cycle 7 Homolog 3
  • EC 2.7.11.1 4
  • Hsk1 3

External Ids for CDC7 Gene

Previous HGNC Symbols for CDC7 Gene

  • CDC7L1

Previous GeneCards Identifiers for CDC7 Gene

  • GC01P091303
  • GC01P091438
  • GC01P091678
  • GC01P091739
  • GC01P091966
  • GC01P090085

Summaries for CDC7 Gene

Entrez Gene Summary for CDC7 Gene

  • This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDC7 Gene

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Diseases associated with CDC7 include Glaucoma 1, Open Angle, E. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Mitotic G1-G1/S phases. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for CDC7 Gene

  • Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Tocris Summary for CDC7 Gene

  • Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.

Gene Wiki entry for CDC7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC7 Gene

Genomics for CDC7 Gene

Regulatory Elements for CDC7 Gene

Enhancers for CDC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F091499 1.1 ENCODE 38 +0.8 760 3.4 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 CDC7 ENSG00000199666 ACTBP12 LOC105378852 HFM1 GC01P091527
GH01F091545 1.5 FANTOM5 Ensembl ENCODE 24.8 +51.1 51117 13.0 PKNOX1 ATF1 ZNF121 GATA2 FOS ZNF263 JUNB TBX21 ZNF585B SMARCA4 CDC7 BTBD8 WDR82P2 LOC102723436
GH01F091019 1.1 ENCODE 10.2 -479.1 -479147 3.5 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 ZNF2 YY1 SLC30A9 CDC7 ZNF644 PIR51118
GH01F091889 1 Ensembl ENCODE 10.9 +390.3 390252 3.1 JUN MAX ZNF384 ZIC2 ZFHX2 GATA3 EED PRDM10 FOS TCF7L2 CDC7 EVI5 TGFBR3 GC01M091855
GH01F091895 0.6 ENCODE 10.9 +393.8 393805 0.3 ESRRA HLF ZNF341 CEBPA CEBPB EP300 CDC7 TGFBR3 GC01M091855
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC7 on UCSC Golden Path with GeneCards custom track

Promoters for CDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000283763 686 2601 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548

Genomic Location for CDC7 Gene

Chromosome:
1
Start:
91,500,814 bp from pter
End:
91,525,764 bp from pter
Size:
24,951 bases
Orientation:
Plus strand

Genomic View for CDC7 Gene

Genes around CDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC7 Gene

Proteins for CDC7 Gene

  • Protein details for CDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00311-CDC7_HUMAN
    Recommended name:
    Cell division cycle 7-related protein kinase
    Protein Accession:
    O00311
    Secondary Accessions:
    • D3DT31
    • O00558
    • Q5T5U5

    Protein attributes for CDC7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63888 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

    Three dimensional structures from OCA and Proteopedia for CDC7 Gene

    Alternative splice isoforms for CDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC7 Gene

Post-translational modifications for CDC7 Gene

  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC7 (CDC7)

No data available for DME Specific Peptides for CDC7 Gene

Domains & Families for CDC7 Gene

Gene Families for CDC7 Gene

Protein Domains for CDC7 Gene

Suggested Antigen Peptide Sequences for CDC7 Gene

Graphical View of Domain Structure for InterPro Entry

O00311

UniProtKB/Swiss-Prot:

CDC7_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
genes like me logo Genes that share domains with CDC7: view

Function for CDC7 Gene

Molecular function for CDC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Enzyme Numbers (IUBMB) for CDC7 Gene

Gene Ontology (GO) - Molecular Function for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IMP 12065429
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 12065429
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDC7: view
genes like me logo Genes that share phenotypes with CDC7: view

Animal Models for CDC7 Gene

MGI Knock Outs for CDC7:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC7 Gene

Localization for CDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4

Gene Ontology (GO) - Cellular Components for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9250678
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA 9250678
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with CDC7: view

Pathways & Interactions for CDC7 Gene

genes like me logo Genes that share pathways with CDC7: view

Pathways by source for CDC7 Gene

1 Cell Signaling Technology pathway for CDC7 Gene
3 BioSystems pathways for CDC7 Gene
1 KEGG pathway for CDC7 Gene
1 GeneGo (Thomson Reuters) pathway for CDC7 Gene

SIGNOR curated interactions for CDC7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IBA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CDC7: view

Drugs & Compounds for CDC7 Gene

(14) Drugs for CDC7 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
DMNB Pharma DNA-PK inhibitor 0
PHA-767491 Pharma Cdc7/cdk9 inhibitor, potent, ATP-competitive 0
XL413 Pharma Cdc7 inhibitor 0
XL413 hydrochloride Pharma Cdc7 inhibitor 0

(3) Additional Compounds for CDC7 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PD 166285 dihydrochloride
212391-63-4
PHA 767491 hydrochloride
942425-68-5

(5) Tocris Compounds for CDC7 Gene

Compound Action Cas Number
AZ 3146 Potent and selective Mps1 kinase inhibitor 1124329-14-1
Mirin MRN-ATM pathway inhibitor 1198097-97-0
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 212391-63-4
PHA 767491 hydrochloride MK2 inhibitor; also inhibits cdc7/cdk9 942425-68-5
SB 218078 Inhibitor of checkpoint kinase 1 (Chk1) 135897-06-2

(4) ApexBio Compounds for CDC7 Gene

Compound Action Cas Number
DMNB 20357-25-9
PHA-767491 Cdc7/cdk9 inhibitor, potent, ATP-competitive 845714-00-3
XL413 Cdc7 inhibitor 1169558-38-6
XL413 hydrochloride Cdc7 inhibitor 1169562-71-3
genes like me logo Genes that share compounds with CDC7: view

Transcripts for CDC7 Gene

Unigene Clusters for CDC7 Gene

Cell division cycle 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CDC7 Gene

GeneLoc Exon Structure for
CDC7
ECgene alternative splicing isoforms for
CDC7

Expression for CDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDC7 Gene

This gene is overexpressed in Heart (30.4), Testis (15.5), Prostate (11.7), and Urinary Bladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC7 Gene



Protein tissue co-expression partners for CDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC7 Gene:

CDC7

SOURCE GeneReport for Unigene cluster for CDC7 Gene:

Hs.533573
genes like me logo Genes that share expression patterns with CDC7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDC7 Gene

Orthologs for CDC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC7 34
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia CDC7 34 35
  • 92.92 (n)
cow
(Bos Taurus)
Mammalia CDC7 34
  • 90.82 (n)
CDC7L1 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC7 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc7 34 16 35
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Cdc7 34
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC7 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC7 34 35
  • 74.05 (n)
lizard
(Anolis carolinensis)
Reptilia CDC7 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc7 34
  • 68.3 (n)
Str.6524 34
African clawed frog
(Xenopus laevis)
Amphibia Cdc7 34
zebrafish
(Danio rerio)
Actinopterygii cdc7 34 35
  • 60.65 (n)
Dr.20362 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002110 34
  • 43.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5790 35
  • 27 (a)
OneToMany
l(1)G0148 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC7 35 37
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for CDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC7 Gene

ENSEMBL:
Gene Tree for CDC7 (if available)
TreeFam:
Gene Tree for CDC7 (if available)

Paralogs for CDC7 Gene

No data available for Paralogs for CDC7 Gene

Variants for CDC7 Gene

Sequence variations from dbSNP and Humsavar for CDC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1046622 -- 91,524,150(+) ATACA(A/G)GGGCA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs10493849 -- 91,510,825(+) CCTAA(C/G)TAAAA intron-variant
rs10493850 -- 91,522,452(+) AAAGA(A/G)AAGTC intron-variant
rs10782953 -- 91,516,997(+) GAGGC(A/G)GAAGT intron-variant
rs10874758 -- 91,515,092(+) GATCA(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC7 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
esv2452061 CNV deletion 19546169

Variation tolerance for CDC7 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC7 Gene

Disorders for CDC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
glaucoma 1, open angle, e
  • primary open angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search CDC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC7

Genetic Association Database (GAD)
CDC7
Human Genome Epidemiology (HuGE) Navigator
CDC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC7
genes like me logo Genes that share disorders with CDC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC7 Gene

Publications for CDC7 Gene

  1. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PMID: 9250678) Sato N. … Masai H. (EMBO J. 1997) 2 3 4 22 64
  2. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PMID: 9405610) Jiang W. … Hunter T. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  3. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PMID: 17062569) Tenca P. … Santocanale C. (J. Biol. Chem. 2007) 3 4 22 64
  4. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N. … Masai H. (J. Biol. Chem. 2005) 3 4 22 64
  5. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H. … Masai H. (Mol. Cell. Biol. 1999) 3 4 22 64

Products for CDC7 Gene

Sources for CDC7 Gene

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