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Aliases for CDC7 Gene

Aliases for CDC7 Gene

  • Cell Division Cycle 7 2 3 5
  • CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1 2 3
  • CDC7-Related Kinase 3 4
  • HsCDC7 3 4
  • HuCDC7 3 4
  • CDC7L1 3 4
  • Cell Division Cycle 7 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 7-Related Protein Kinase 3
  • CDC7 Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7-Like Protein 1 3
  • Cell Division Cycle 7 Homolog 3
  • EC 2.7.11.1 4
  • Hsk1 3

External Ids for CDC7 Gene

Previous HGNC Symbols for CDC7 Gene

  • CDC7L1

Previous GeneCards Identifiers for CDC7 Gene

  • GC01P091303
  • GC01P091438
  • GC01P091678
  • GC01P091739
  • GC01P091966
  • GC01P090085

Summaries for CDC7 Gene

Entrez Gene Summary for CDC7 Gene

  • This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDC7 Gene

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Among its related pathways are DNA Damage and E2F mediated regulation of DNA replication. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for CDC7 Gene

  • Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Tocris Summary for CDC7 Gene

  • Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.

Gene Wiki entry for CDC7 Gene

Additional gene information for CDC7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC7 Gene

Genomics for CDC7 Gene

Regulatory Elements for CDC7 Gene

Enhancers for CDC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H091545 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +51.1 51117 12 HDAC1 PKNOX1 ATF1 BATF RAD21 GATA2 FOS ATF7 RUNX3 CREM CDC7 WDR82P2 LOC102723436
GH01H091499 1.1 ENCODE 38 +0.8 760 3 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 CDC7 SNORD3G ACTBP12 LOC105378852 HFM1 ZNF644 GC01P091527
GH01H091889 1.3 Ensembl ENCODE dbSUPER 10.9 +390.2 390190 2 FOXA2 JUN MAX ZNF384 ZIC2 ZFHX2 GATA3 EED ZSCAN5C FOS CDC7 EVI5 TGFBR3 GC01M091855
GH01H091523 0.4 dbSUPER 22.3 +23.0 23005 1 ATF7 BATF CDC7 GC01P091527
GH01H091581 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +82.3 82326 2 KLF1 ZNF10 CHD1 USF2 ELF1 ZEB2 ZIC2 ZSCAN21 CTBP1 JUND CDC7 LOC102723436 RPL39P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC7 on UCSC Golden Path with GeneCards custom track

Promoters for CDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009706 486 1801 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 ZNF207 ZNF548

Genomic Location for CDC7 Gene

Chromosome:
1
Start:
91,500,814 bp from pter
End:
91,525,764 bp from pter
Size:
24,951 bases
Orientation:
Plus strand

Genomic View for CDC7 Gene

Genes around CDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC7 Gene

Proteins for CDC7 Gene

  • Protein details for CDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00311-CDC7_HUMAN
    Recommended name:
    Cell division cycle 7-related protein kinase
    Protein Accession:
    O00311
    Secondary Accessions:
    • D3DT31
    • O00558
    • Q5T5U5

    Protein attributes for CDC7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63888 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

    Three dimensional structures from OCA and Proteopedia for CDC7 Gene

    Alternative splice isoforms for CDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC7 Gene

Post-translational modifications for CDC7 Gene

  • Ubiquitination at posLast=212212
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC7 (CDC7)

No data available for DME Specific Peptides for CDC7 Gene

Domains & Families for CDC7 Gene

Gene Families for CDC7 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC7 Gene

Suggested Antigen Peptide Sequences for CDC7 Gene

Graphical View of Domain Structure for InterPro Entry

O00311

UniProtKB/Swiss-Prot:

CDC7_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
genes like me logo Genes that share domains with CDC7: view

Function for CDC7 Gene

Molecular function for CDC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Enzyme Numbers (IUBMB) for CDC7 Gene

Phenotypes From GWAS Catalog for CDC7 Gene

Gene Ontology (GO) - Molecular Function for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IMP 12065429
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 12065429
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDC7: view
genes like me logo Genes that share phenotypes with CDC7: view

Animal Models for CDC7 Gene

MGI Knock Outs for CDC7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC7 Gene

Localization for CDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Mitotic spindle (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9250678
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9250678
GO:0045171 intercellular bridge IDA --
GO:0072686 mitotic spindle IDA --
genes like me logo Genes that share ontologies with CDC7: view

Pathways & Interactions for CDC7 Gene

genes like me logo Genes that share pathways with CDC7: view

Pathways by source for CDC7 Gene

1 KEGG pathway for CDC7 Gene
1 GeneGo (Thomson Reuters) pathway for CDC7 Gene

SIGNOR curated interactions for CDC7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IBA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CDC7: view

Drugs & Compounds for CDC7 Gene

(14) Drugs for CDC7 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BMS-863233 Investigational Pharma 0
DMNB Pharma DNA-PK inhibitor 0
PHA-767491 Pharma Cdc7/cdk9 inhibitor, potent, ATP-competitive 0
XL413 Pharma Cdc7 inhibitor 0
XL413 hydrochloride Pharma Cdc7 inhibitor 0

(3) Additional Compounds for CDC7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PD 166285 dihydrochloride
212391-63-4
PHA 767491 hydrochloride
942425-68-5

(5) Tocris Compounds for CDC7 Gene

Compound Action Cas Number
AZ 3146 Potent and selective Mps1 kinase inhibitor 1124329-14-1
Mirin MRN-ATM pathway inhibitor 1198097-97-0
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 212391-63-4
PHA 767491 hydrochloride MK2 inhibitor; also inhibits cdc7/cdk9 942425-68-5
SB 218078 Inhibitor of checkpoint kinase 1 (Chk1) 135897-06-2

(4) ApexBio Compounds for CDC7 Gene

Compound Action Cas Number
DMNB 20357-25-9
PHA-767491 Cdc7/cdk9 inhibitor, potent, ATP-competitive 845714-00-3
XL413 Cdc7 inhibitor 1169558-38-6
XL413 hydrochloride Cdc7 inhibitor 1169562-71-3
genes like me logo Genes that share compounds with CDC7: view

Drug Products

Transcripts for CDC7 Gene

Unigene Clusters for CDC7 Gene

Cell division cycle 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CDC7 Gene

GeneLoc Exon Structure for
CDC7
ECgene alternative splicing isoforms for
CDC7

Expression for CDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDC7 Gene

This gene is overexpressed in Heart (30.4), Testis (15.5), Prostate (11.7), and Urinary Bladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC7 Gene



Protein tissue co-expression partners for CDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC7 Gene:

CDC7

SOURCE GeneReport for Unigene cluster for CDC7 Gene:

Hs.533573

Evidence on tissue expression from TISSUES for CDC7 Gene

  • Liver(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CDC7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC7 Gene

Orthologs for CDC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC7 33
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia CDC7 33 34
  • 92.92 (n)
cow
(Bos Taurus)
Mammalia CDC7 33
  • 90.82 (n)
CDC7L1 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC7 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc7 33 16 34
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Cdc7 33
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC7 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC7 33 34
  • 74.05 (n)
lizard
(Anolis carolinensis)
Reptilia CDC7 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc7 33
  • 68.3 (n)
Str.6524 33
African clawed frog
(Xenopus laevis)
Amphibia Cdc7 33
zebrafish
(Danio rerio)
Actinopterygii cdc7 33 34
  • 60.65 (n)
Dr.20362 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002110 33
  • 43.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5790 34
  • 27 (a)
OneToMany
l(1)G0148 34
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC7 34 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToOne
Species where no ortholog for CDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC7 Gene

ENSEMBL:
Gene Tree for CDC7 (if available)
TreeFam:
Gene Tree for CDC7 (if available)

Paralogs for CDC7 Gene

No data available for Paralogs for CDC7 Gene

Variants for CDC7 Gene

Sequence variations from dbSNP and Humsavar for CDC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000114537 -- 91,522,884(+) ATCCA(-/CAGT)CAGAT intron-variant
rs1000187232 -- 91,523,172(+) TTGCG(A/C)GTCTC intron-variant
rs1000326672 -- 91,520,929(+) TGTAC(C/T)TCATA intron-variant
rs1000468310 -- 91,509,946(+) AGTGA(A/G)ACTGG intron-variant
rs1000563132 -- 91,510,240(+) GAGTG(A/G)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC7 Gene

Variant ID Type Subtype PubMed ID
esv2452061 CNV deletion 19546169
esv2714684 CNV deletion 23290073

Variation tolerance for CDC7 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC7 Gene

Disorders for CDC7 Gene

Relevant External Links for CDC7

Genetic Association Database (GAD)
CDC7
Human Genome Epidemiology (HuGE) Navigator
CDC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC7

No disorders were found for CDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC7 Gene

Publications for CDC7 Gene

  1. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PMID: 9405610) Jiang W … Hunter T (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 60
  2. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PMID: 9250678) Sato N … Masai H (The EMBO journal 1997) 2 3 4 22 60
  3. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PMID: 17062569) Tenca P … Santocanale C (The Journal of biological chemistry 2007) 3 4 22 60
  4. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N … Masai H (The Journal of biological chemistry 2005) 3 4 22 60
  5. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H … Masai H (Molecular and cellular biology 1999) 3 4 22 60

Products for CDC7 Gene

Sources for CDC7 Gene

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