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Aliases for CDC7 Gene

Aliases for CDC7 Gene

  • Cell Division Cycle 7 2 3
  • CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1 2 3
  • CDC7-Related Kinase 3 4
  • HsCDC7 3 4
  • HuCDC7 3 4
  • CDC7L1 3 4
  • Cell Division Cycle 7 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 7-Related Protein Kinase 3
  • CDC7 Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7-Like Protein 1 3
  • Cell Division Cycle 7 Homolog 3
  • EC 2.7.11.1 4
  • CDC7L1, 6
  • Hsk1 3

External Ids for CDC7 Gene

Previous Symbols for CDC7 Gene

  • CDC7L1

Summaries for CDC7 Gene

Entrez Gene Summary for CDC7 Gene

  • This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDC7 Gene

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity.

UniProtKB/Swiss-Prot for CDC7 Gene

  • Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Gene Wiki entry for CDC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC7 Gene

Genomics for CDC7 Gene

Genomic Location for CDC7 Gene

Start:
91,500,814 bp from pter
End:
91,525,764 bp from pter
Size:
24,951 bases
Orientation:
Plus strand

Genomic View for CDC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC7 Gene

Regulatory Elements for CDC7 Gene

Proteins for CDC7 Gene

  • Protein details for CDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00311-CDC7_HUMAN
    Recommended name:
    Cell division cycle 7-related protein kinase
    Protein Accession:
    O00311
    Secondary Accessions:
    • D3DT31
    • O00558
    • Q5T5U5

    Protein attributes for CDC7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63888 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity

    Three dimensional structures from OCA and Proteopedia for CDC7 Gene

    Alternative splice isoforms for CDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC7 Gene

Proteomics data for CDC7 Gene at MOPED

Post-translational modifications for CDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys212

Other Protein References for CDC7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC7 Gene

Domains for CDC7 Gene

Gene Families for CDC7 Gene

Protein Domains for CDC7 Gene

UniProtKB/Swiss-Prot:

CDC7_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O00311
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.:
    • O00311
genes like me logo Genes that share domains with CDC7: view

Function for CDC7 Gene

Molecular function for CDC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Enzyme Numbers (IUBMB) for CDC7 Gene

Gene Ontology (GO) - Molecular Function for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IMP 12065429
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12065429
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDC7: view
genes like me logo Genes that share phenotypes with CDC7: view

Animal Models for CDC7 Gene

MGI Knock Outs for CDC7:

No data available for Transcription Factor Targeting and HOMER Transcription for CDC7 Gene

Localization for CDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC7 Gene COMPARTMENTS Subcellular localization image for CDC7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9250678
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9250678
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with CDC7: view

Pathways for CDC7 Gene

genes like me logo Genes that share pathways with CDC7: view

Pathways by source for CDC7 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDC7 Gene
1 Cell Signaling Technology pathway for CDC7 Gene
3 BioSystems pathways for CDC7 Gene
1 KEGG pathway for CDC7 Gene

Gene Ontology (GO) - Biological Process for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IBA --
genes like me logo Genes that share ontologies with CDC7: view

Compounds for CDC7 Gene

(5) Tocris Compounds for CDC7 Gene

Compound Action Cas Number
Compound 401 Selective DNA-PK and mTOR inhibitor [168425-64-7]
DIM Activates Chk2; induces G2/M cell cycle arrest [1968-05-4]
Mirin MRN-ATM pathway inhibitor [1198097-97-0]
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 [212391-63-4]
PHA 767491 hydrochloride Dual cdc7/cdk9 inhibitor. Also inhibits MK2 [942425-68-5]

(2) HMDB Compounds for CDC7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Novoseek inferred chemical compound relationships for CDC7 Gene

Compound -log(P) Hits PubMed IDs
threonine 51.5 8
serine 38.5 6
caffeine 16.4 1
alanine 13 3
genes like me logo Genes that share compounds with CDC7: view

Transcripts for CDC7 Gene

Unigene Clusters for CDC7 Gene

Cell division cycle 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CDC7 Gene

GeneLoc Exon Structure for
CDC7
ECgene alternative splicing isoforms for
CDC7

Expression for CDC7 Gene

mRNA expression in normal human tissues for CDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC7 Gene

SOURCE GeneReport for Unigene cluster for CDC7 Gene Hs.533573

genes like me logo Genes that share expressions with CDC7: view

Orthologs for CDC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC7 36
  • 98.56 (n)
  • 97.67 (a)
cow
(Bos Taurus)
Mammalia CDC7 36
  • 90.82 (n)
  • 89.37 (a)
CDC7L1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC7 36
  • 92.92 (n)
  • 90.59 (a)
CDC7 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc7 36
  • 83.21 (n)
  • 81.43 (a)
Cdc7 16
Cdc7 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC7 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC7 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc7 36
  • 81.94 (n)
  • 81.46 (a)
chicken
(Gallus gallus)
Aves CDC7 36
  • 74.05 (n)
  • 69.78 (a)
CDC7 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC7 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Cdc7 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc7 36
  • 68.3 (n)
  • 66.88 (a)
Str.6524 36
zebrafish
(Danio rerio)
Actinopterygii cdc7 36
  • 60.65 (n)
  • 63.66 (a)
cdc7 37
  • 53 (a)
OneToOne
Dr.20362 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002110 36
  • 43.75 (n)
  • 39.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5790 37
  • 27 (a)
OneToMany
l(1)G0148 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC7 37
  • 28 (a)
OneToOne
CDC7 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for CDC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC7 Gene

ENSEMBL:
Gene Tree for CDC7 (if available)
TreeFam:
Gene Tree for CDC7 (if available)

Paralogs for CDC7 Gene

No data available for Paralogs for CDC7 Gene

Variants for CDC7 Gene

Sequence variations from dbSNP and Humsavar for CDC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs403933 -- 91,504,256(+) atgtg(C/G)cgcta intron-variant
rs404558 -- 91,519,459(+) tttgg(A/T)ttgtt intron-variant
rs409052 -- 91,519,417(+) gaggg(A/G)gacct intron-variant
rs415061 -- 91,516,736(+) GAGCC(A/G)AGGAA intron-variant
rs416864 -- 91,502,421(+) tttgt(C/T)aaata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC7 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
esv2452061 CNV Deletion 19546169

Relevant External Links for CDC7 Gene

HapMap Linkage Disequilibrium report
CDC7

Disorders for CDC7 Gene

(3) Novoseek inferred disease relationships for CDC7 Gene

Disease -log(P) Hits PubMed IDs
ataxia telangiectasia 39.6 2
cancer 2.98 6
tumors 2.83 7

Relevant External Links for CDC7

Genetic Association Database (GAD)
CDC7
Human Genome Epidemiology (HuGE) Navigator
CDC7
genes like me logo Genes that share disorders with CDC7: view

No data available for UniProtKB/Swiss-Prot for CDC7 Gene

Publications for CDC7 Gene

  1. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PMID: 9250678) Sato N. … Masai H. (EMBO J. 1997) 2 3 4 23
  2. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PMID: 9405610) Jiang W. … Hunter T. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  3. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H. … Masai H. (Mol. Cell. Biol. 1999) 3 4 23
  4. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N. … Masai H. (J. Biol. Chem. 2005) 3 4 23
  5. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PMID: 17062569) Tenca P. … Santocanale C. (J. Biol. Chem. 2007) 3 4 23

Products for CDC7 Gene

Sources for CDC7 Gene

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