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Aliases for CDC7 Gene

Aliases for CDC7 Gene

  • Cell Division Cycle 7 2 3 5
  • CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1 2 3
  • CDC7-Related Kinase 3 4
  • HsCDC7 3 4
  • HuCDC7 3 4
  • CDC7L1 3 4
  • Cell Division Cycle 7 Homolog (S. Cerevisiae) 2
  • CDC7 Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7 (S. Cerevisiae) 2
  • Cell Division Cycle 7-Like Protein 1 3
  • Cell Division Cycle 7 Homolog 3
  • EC 2.7.11.1 4
  • Hsk1 3

External Ids for CDC7 Gene

Previous HGNC Symbols for CDC7 Gene

  • CDC7L1

Previous GeneCards Identifiers for CDC7 Gene

  • GC01P091303
  • GC01P091438
  • GC01P091678
  • GC01P091739
  • GC01P091966
  • GC01P090085

Summaries for CDC7 Gene

Entrez Gene Summary for CDC7 Gene

  • This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

GeneCards Summary for CDC7 Gene

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Among its related pathways are Cell Cycle Checkpoints and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for CDC7 Gene

  • Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Tocris Summary for CDC7 Gene

  • Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed.

Gene Wiki entry for CDC7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC7 Gene

Genomics for CDC7 Gene

Regulatory Elements for CDC7 Gene

Enhancers for CDC7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC7 on UCSC Golden Path with GeneCards custom track

Promoters for CDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC7 Gene

Chromosome:
1
Start:
91,500,814 bp from pter
End:
91,525,764 bp from pter
Size:
24,951 bases
Orientation:
Plus strand

Genomic View for CDC7 Gene

Genes around CDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC7 Gene

Proteins for CDC7 Gene

  • Protein details for CDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00311-CDC7_HUMAN
    Recommended name:
    Cell division cycle 7-related protein kinase
    Protein Accession:
    O00311
    Secondary Accessions:
    • D3DT31
    • O00558
    • Q5T5U5

    Protein attributes for CDC7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63888 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

    Three dimensional structures from OCA and Proteopedia for CDC7 Gene

    Alternative splice isoforms for CDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC7 Gene

Proteomics data for CDC7 Gene at MOPED

Post-translational modifications for CDC7 Gene

  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC7 (CDC7)

No data available for DME Specific Peptides for CDC7 Gene

Domains & Families for CDC7 Gene

Gene Families for CDC7 Gene

Protein Domains for CDC7 Gene

Suggested Antigen Peptide Sequences for CDC7 Gene

Graphical View of Domain Structure for InterPro Entry

O00311

UniProtKB/Swiss-Prot:

CDC7_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
genes like me logo Genes that share domains with CDC7: view

Function for CDC7 Gene

Molecular function for CDC7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Enzyme Numbers (IUBMB) for CDC7 Gene

genes like me logo Genes that share phenotypes with CDC7: view

Animal Models for CDC7 Gene

MGI Knock Outs for CDC7:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC7 Gene

Localization for CDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC7 Gene COMPARTMENTS Subcellular localization image for CDC7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4

No data available for Gene Ontology (GO) - Cellular Components for CDC7 Gene

Pathways & Interactions for CDC7 Gene

genes like me logo Genes that share pathways with CDC7: view

Pathways by source for CDC7 Gene

1 Cell Signaling Technology pathway for CDC7 Gene
3 BioSystems pathways for CDC7 Gene
1 KEGG pathway for CDC7 Gene
1 GeneGo (Thomson Reuters) pathway for CDC7 Gene

SIGNOR curated interactions for CDC7 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006270 DNA replication initiation IBA --
GO:0006468 protein phosphorylation IEA --
GO:0006909 phagocytosis IBA --
GO:0008284 positive regulation of cell proliferation IMP 17102137
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with CDC7: view

Drugs & Compounds for CDC7 Gene

(11) Drugs for CDC7 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
PHA-767491 Pharma Cdc7/cdk9 inhibitor, potent, ATP-competitive 0
XL413 hydrochloride Pharma Cdc7 inhibitor 0
BMS-863233 Pharma 0
NMS-1116354 Pharma 0

(3) Additional Compounds for CDC7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
DMNB
20357-25-9
PD 407824
622864-54-4

(4) Tocris Compounds for CDC7 Gene

Compound Action Cas Number
DMNB DNA-PK inhibitor 20357-25-9
NU 7026 Selective DNA-PK inhibitor 154447-35-5
PD 407824 Selective inhibitor of Chk1 and Wee1 622864-54-4
SB 218078 Inhibitor of checkpoint kinase 1 (Chk1) 135897-06-2

(2) ApexBio Compounds for CDC7 Gene

Compound Action Cas Number
PHA-767491 Cdc7/cdk9 inhibitor, potent, ATP-competitive 845714-00-3
XL413 hydrochloride Cdc7 inhibitor 1169562-71-3
genes like me logo Genes that share compounds with CDC7: view

Transcripts for CDC7 Gene

Unigene Clusters for CDC7 Gene

Cell division cycle 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CDC7 Gene

GeneLoc Exon Structure for
CDC7
ECgene alternative splicing isoforms for
CDC7

Expression for CDC7 Gene

mRNA expression in normal human tissues for CDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDC7 Gene

This gene is overexpressed in Heart (30.4), Testis (15.5), Prostate (11.7), and Urinary Bladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC7 Gene



SOURCE GeneReport for Unigene cluster for CDC7 Gene Hs.533573

genes like me logo Genes that share expression patterns with CDC7: view

Protein tissue co-expression partners for CDC7 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDC7 Gene

Orthologs for CDC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC7 35
  • 90.82 (n)
  • 89.37 (a)
CDC7L1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC7 35
  • 92.92 (n)
  • 90.59 (a)
CDC7 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc7 35
  • 83.21 (n)
  • 81.43 (a)
Cdc7 16
Cdc7 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC7 35
  • 98.56 (n)
  • 97.67 (a)
rat
(Rattus norvegicus)
Mammalia Cdc7 35
  • 81.94 (n)
  • 81.46 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC7 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC7 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC7 35
  • 74.05 (n)
  • 69.78 (a)
CDC7 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC7 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc7 35
  • 68.3 (n)
  • 66.88 (a)
Str.6524 35
African clawed frog
(Xenopus laevis)
Amphibia Cdc7 35
zebrafish
(Danio rerio)
Actinopterygii cdc7 35
  • 60.65 (n)
  • 63.66 (a)
Dr.20362 35
cdc7 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002110 35
  • 43.75 (n)
  • 39.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5790 36
  • 27 (a)
OneToMany
l(1)G0148 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC7 36
  • 28 (a)
OneToOne
CDC7 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for CDC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC7 Gene

ENSEMBL:
Gene Tree for CDC7 (if available)
TreeFam:
Gene Tree for CDC7 (if available)

Paralogs for CDC7 Gene

No data available for Paralogs for CDC7 Gene

Variants for CDC7 Gene

Sequence variations from dbSNP and Humsavar for CDC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13447459 - 91,501,784(+) GTTTC(A/C)GGCTG reference, missense
rs13447492 - 91,508,357(+) ATCCT(A/G/T)TAAGA reference, missense, utr-variant-5-prime
rs13447493 - 91,508,396(+) TGGCT(G/T)GGTAG reference, missense, utr-variant-5-prime
rs13447503 - 91,511,837(+) CTGTT(C/G)AAAGC reference, missense
VAR_019259 -

Structural Variations from Database of Genomic Variants (DGV) for CDC7 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
esv2452061 CNV Deletion 19546169

Variation tolerance for CDC7 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDC7 Gene

Disorders for CDC7 Gene

Relevant External Links for CDC7

Genetic Association Database (GAD)
CDC7
Human Genome Epidemiology (HuGE) Navigator
CDC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC7

No disorders were found for CDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC7 Gene

Publications for CDC7 Gene

  1. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PMID: 9250678) Sato N. … Masai H. (EMBO J. 1997) 2 3 4 23 67
  2. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PMID: 9405610) Jiang W. … Hunter T. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  3. Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi. (PMID: 19278428) Clarke L.E. … Helm K.F. (J. Cutan. Pathol. 2009) 3 23
  4. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. (PMID: 19318489) Kulkarni A.A. … Williams G.H. (Clin. Cancer Res. 2009) 3 23
  5. Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. (PMID: 19647517) Chuang L.C. … Reed S.I. (Mol. Cell 2009) 3 23

Products for CDC7 Gene

Sources for CDC7 Gene

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