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CDC7 Gene

protein-coding   GIFtS: 68
GCID: GC01P091966

Cell Division Cycle 7

(Previous names: CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like...)
(Previous symbol: CDC7L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 71 2     Hsk12
CDC7L11 2 3 5     Cell Division Cycle 7 Homolog2
CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 11 2     Cell Division Cycle 7-Like Protein 12
CDC7-Related Kinase2 3     Cell Division Cycle 7-Related Protein Kinase2
CDC7 Cell Division Cycle 7 (S. Cerevisiae)1     huCDC72
Cell Division Cycle 7 (S. Cerevisiae)1     EC 2.7.11.13
Cell Division Cycle 7 Homolog (S. Cerevisiae)1     HsCdc73
HsCDC72     huCdc73

External Ids:    HGNC: 17451   Entrez Gene: 83172   Ensembl: ENSG000000970467   OMIM: 6033115   UniProtKB: O003113   

Export aliases for CDC7 gene to outside databases

Previous GC identifers: GC01P091303 GC01P091438 GC01P091678 GC01P091739 GC01P090085


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC7 Gene:
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The
yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this
gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced
transcript variants that encode the same protein have been detected. (provided by RefSeq, Aug 2008)

GeneCards Summary for CDC7 Gene:
CDC7 (cell division cycle 7) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity.

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311
Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA
replication. Can phosphorylates MCM2 and MCM3

Gene Wiki entry for CDC7 (Cell division cycle 7-related protein kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC7 gene promoter:
         GR   AML1a   Pax-6   GR-alpha   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC7 promoter sequence
   Search Chromatin IP Primers for CDC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22

CDC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P091966:  view genomic region     (about GC identifiers)

Start:
91,966,404 bp from pter      End:
91,991,321 bp from pter
Size:
24,918 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311 (See protein sequence)
Recommended Name: Cell division cycle 7-related protein kinase  
Size: 574 amino acids; 63888 Da
Cofactor: Magnesium
Subunit: Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity
4 PDB 3D structures from and Proteopedia for CDC7:
4F99 (3D)        4F9A (3D)        4F9B (3D)        4F9C (3D)    
Secondary accessions: D3DT31 O00558 Q5T5U5
Alternative splicing: 1 isoform:  O00311-1   

Explore the universe of human proteins at neXtProt for CDC7: NX_O00311

Explore proteomics data for CDC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys212
  • Modification sites at PhosphoSitePlus

  • See CDC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001127891.1  NP_001127892.1  NP_003494.1  

    ENSEMBL proteins: 
     ENSP00000234626   ENSP00000398077   ENSP00000407477   ENSP00000393139  
    Reactome Protein details: O00311

    CDC7 Human Recombinant Protein Products:

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    Novus Biologicals CDC7 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC7

     
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    antibodies-online proteins for CDC7 (4 products) 

     
    Search antibodies-online for peptides for CDC7

    CDC7 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: cell division cycle 7 homolog (S. cerevisiae)
    CDC7 family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O00311

    ProtoNet protein and cluster: O00311

    UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC7_HUMAN, O00311
    Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA
    replication. Can phosphorylates MCM2 and MCM3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IMP12065429
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12065429
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDC7           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDC7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with RAF26  Paclitaxel antagonistic effect 
     Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdc7):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with CDC7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdc7tm1Hmas for CDC7

       genOway: Develop your customized and physiologically relevant rodent model for CDC7

    miRNA
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    miRTarBase miRNAs that target CDC7:
    hsa-mir-192-5p (MIRT004845), hsa-let-7a-5p (MIRT052381), hsa-mir-215-5p (MIRT024755), hsa-mir-101-3p (MIRT027255), hsa-mir-615-3p (MIRT039691)

    Block miRNA regulation of human, mouse, rat CDC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC7 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCDC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC7
    Predesigned siRNA for gene silencing in human, mouse, rat CDC7

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDC7 (NM_003503)
    Sino Biological Human cDNA Clone for CDC7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC7_HUMAN, O00311: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA9250678
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with CDC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    DNA Replication0.92
    DNA Replication Pre-Initiation0.81
    M/G1 Transition0.81
    Cell Cycle Checkpoints0.58
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84


    Find genes that share SuperPaths with CDC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC7
        Cell Cycle Control of Chromosomal Replication
    Mitotic Roles of Polo Like Kinases

    1 Cell Signaling Technology (CST) Pathway for CDC7
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDC7
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for CDC7
        Cell cycle
    DNA Replication
    RB in Cancer


    2 Reactome Pathways for CDC7
        Activation of ATR in response to replication stress
    Activation of the pre-replicative complex


    1 Kegg Pathway  (Kegg details for CDC7):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC7
    Interactions:

        GeneGlobe Interaction Network for CDC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC7 (O003112, 3 ENSP000002346264) via UniProtKB, MINT, STRING, and/or I2D (see all 266)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=1 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=1 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=1 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006468protein phosphorylation ----
    GO:0008284positive regulation of cell proliferation IMP17102137

    Find genes that share ontologies with CDC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CDC7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DIMActivates Chk2; induces G2/M cell cycle arrest[1968-05-4]
    Compound 401Selective DNA-PK and mTOR inhibitor[168425-64-7]
    MirinMRN-ATM pathway inhibitor[1198097-97-0]
    PHA 767491 hydrochlorideDual cdc7/cdk9 inhibitor. Also inhibits MK2[942425-68-5]
    PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 [212391-63-4]

    2 HMDB Compounds for CDC7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for CDC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 51.5 10 10846177 (2), 17046832 (1), 18714392 (1), 11250080 (1) (see all 7)
    serine 38.5 6 17046832 (1), 18714392 (1), 11441535 (1), 16864800 (1) (see all 6)
    caffeine 16.4 1 15220931 (1)
    alanine 13 3 17046832 (1), 16864800 (1), 10846177 (1)



    Find genes that share compounds with CDC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC7 gene (3 alternative transcripts): 
    NM_001134419.1  NM_001134420.1  NM_003503.3  

    Unigene Cluster for CDC7:

    Cell division cycle 7
    Hs.533573  [show with all ESTs]
    Unigene Representative Sequence: AB209337
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234626(uc001doe.3 uc001dof.3 uc010osw.2 uc009wdd.3)
    ENST00000426137 ENST00000497611 ENST00000486509 ENST00000430031 ENST00000428239(uc009wdc.3)

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    Selected qRT-PCR Assays for microRNAs that regulate CDC7 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944
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      QuantiTect SYBR Green Assays in human, mouse, rat CDC7
      QuantiFast Probe-based Assays in human, mouse, rat CDC7

    Additional mRNA sequence: 

    AB003698.1 AB209337.1 AF005209.1 AF015592.1 AK298963.1 AK312726.1 AY312583.1 BC110526.1 
    BC110527.1 BC111044.1 

    9 DOTS entries:

    DT.314780  DT.92037489  DT.100812839  DT.99972354  DT.75164847  DT.121342092  DT.95364370  DT.97819446 
    DT.95124348 

    Selected AceView cDNA sequences (see all 92):

    AU120443 AW574512 AA291015 AL602215 D20593 N79336 NM_003503 AY312583 
    AA429583 BG170872 BM789148 AB003698 CB959717 BF432510 AA488999 AU116849 
    BG403744 AI435106 AI434385 BU657893 BU568048 AA885165 BX103240 AA954964 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDC7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:                                                              -           -                                 
    SP2:                                            -                 -           -                                 
    SP3:                                                              -           -     -                           
    SP4:                                                                          -                                 
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CDC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCATTTT
    CDC7 Expression
    About this image


    CDC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Retina
    CDC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533573
        Custom PCR Arrays for CDC7
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CDC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc71 , 5 cell division cycle 7 (S. cerevisiae)1, 5 83.21(n)1
    81.43(a)1
      5 (51.43 cM)5
    125451  NM_009863.31  NP_033993.21 
     1069643225 
    chicken
    (Gallus gallus)
    Aves CDC71 cell division cycle 7 homolog (S. cerevisiae) 74.05(n)
    69.78(a)
      424507  XM_004936620.1  XP_004936677.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC76
    cell division cycle 7
    65(a)
    1 ↔ 1
    4(94514181-94540170)
    African clawed frog
    (Xenopus laevis)
    Amphibia Cdc72 protein kinase Cdc7 76.41(n)    AF080068.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203622 Transcribed sequence with weak similarity to protein more 74.9(n)    57054035 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G01486
    CG57906
    --
    27(a)
    27(a)
    many → 1
    many → 1
    X(6548649-6553742)
    2L(18294904-18297261)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC7(YDL017W)4 DDK (Dbf4-dependent kinase) catalytic subunit required more   --   4(424209-425732) 851545  NP_010267.1 


    ENSEMBL Gene Tree for CDC7 (if available)
    TreeFam Gene Tree for CDC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC7 (see all 610)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898011791,2
    --91964407(+) ATATCA/GTATAG 2 -- us2k10--------
    rs1828277421,2
    --91964431(+) TTCATC/TTATAA 2 -- us2k10--------
    rs1468274341,2
    --91964547(+) GTTAAC/TGACCT 2 -- us2k10--------
    rs1869878121,2
    C--91964605(+) GTATTG/TCTTGT 2 -- us2k10--------
    rs1392400211,2
    --91964883(+) TAGGAG/TAAGGA 3 -- us2k10--------
    rs1433560501,2
    --91964919(+) GGCAAA/TGTTGA 3 -- us2k10--------
    rs127177981,2
    C,F--91964946(+) acataT/Cgatta 3 -- us2k16Minor allele frequency- C:0.20NS NA EA 424
    rs134474481,2
    C,F--91964947(+) CATATG/AATTAT 3 -- us2k12Minor allele frequency- A:0.04NS NA 300
    rs127177991,2
    C,F,H--91964984(+) tatcaC/Tggtca 3 -- us2k18Minor allele frequency- T:0.02NS EA NA 724
    rs5654511,2
    C,F,A,H--91965131(-) aaagcG/Agacct 3 -- us2k123Minor allele frequency- A:0.13NS EA NA WA CSA 1327

    HapMap Linkage Disequilibrium report for CDC7 (91966404 - 91991321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714684CNV Deletion23290073
    esv2452061CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC7
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603311    OMIM disorders: --


    Find genes that share disorders with CDC7           About GenesLikeMe

    3 Novoseek inferred disease relationships for CDC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 39.6 2 16446360 (2)
    cancer 2.98 7 18714392 (1), 17062569 (1), 19115845 (1), 15466207 (1) (see all 6)
    tumors 2.83 13 18714392 (2), 19318489 (2), 19278428 (1), 15466207 (1) (see all 5)

    Genetic Association Database (GAD): CDC7
    Human Genome Epidemiology (HuGE) Navigator: CDC7 (3 documents)

    Export disorders for CDC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC7 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with CDC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PubMed id 9250678)1, 2, 3, 9 Sato N.... Masai H. (EMBO J. 1997)
    2. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PubMed id 9405610)1, 2, 3, 9 Jiang W. and Hunter T. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PubMed id 10373557)1, 2, 9 Kumagai H.... Masai H. (Mol. Cell. Biol. 1999)
    4. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PubMed id 17062569)1, 2, 9 Tenca P....Santocanale C. (J. Biol. Chem. 2007)
    5. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PubMed id 15668232)1, 2, 9 Yoshizawa-Sugata N....Masai H. (J. Biol. Chem. 2005)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Drf1, a novel regulatory subunit for human Cdc7 kinase. (PubMed id 12065429)1, 2 Montagnoli A.... Santocanale C. (EMBO J. 2002)
    10. A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. (PubMed id 9573348)1, 2 Hess G.F....Hollingsworth R.E. (Gene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8317 HGNC: 1745 AceView: CDC7 Ensembl:ENSG00000097046 euGenes: HUgn8317
    ECgene: CDC7 Kegg: 8317 H-InvDB: CDC7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC7 gene:
    Search GeneIP for patents involving CDC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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