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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC7 Gene

protein-coding GIFtS: 66
GCID: GC01P091966

cell division cycle 7

(Previous names: CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like...)
(Previous symbol: CDC7L1)

Explore 11 diseases affiliated with
CDC7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 7¹ ²		Cell Division Cycle 7 (S. Cerevisiae)¹
CDC7L1¹ ² ³ ⁵		Cell Division Cycle 7 Homolog (S. Cerevisiae)¹
Hsk1¹ ²		HsCDC7²
CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1¹ ²		Cell Division Cycle 7 Homolog²
HsCdc7¹ ³		Cell Division Cycle 7-Like Protein 1²
HuCdc7¹		Cell Division Cycle 7-Related Protein Kinase²
CDC7-Related Kinase² ³		HuCDC7¹
CDC7 Cell Division Cycle 7 (S. Cerevisiae)¹		EC 2.7.11.1³

External Ids:	HGNC: 1745¹	Entrez Gene: 8317²	Ensembl: ENSG00000097046⁷	OMIM: 603311⁵	UniProtKB: O00311³

Export aliases for CDC7 gene to outside databases

Previous GC identifers: GC01P091303 GC01P091438 GC01P091678 GC01P091739 GC01P090085

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC7:

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The

yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene

product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript

variants that encode the same protein have been detected. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311

Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication.

Can phosphorylates MCM2 and MCM3

Gene Wiki entry for CDC7 (Cell division cycle 7-related protein kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC7 gene promoter:
GR AML1a Pax-6 GR-alpha Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC7 promoter sequence

Search SABiosciences Chromatin IP Primers for CDC7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22 Ensembl cytogenetic band: 1p22.2 HGNC cytogenetic band: 1p22

CDC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC7 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P091966: view genomic region (about GC identifiers)

Start:	91,966,404 bp from pter	End:	91,991,321 bp from pter
Size:	24,918 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311 (See protein sequence)

Recommended Name: Cell division cycle 7-related protein kinase

Size: 574 amino acids; 63888 Da

Cofactor: Magnesium

Subunit: Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity

Subcellular location: Nucleus

4 PDB 3D structures from and Proteopedia for CDC7:

4F99 (3D)

4F9A (3D)

4F9B (3D)

4F9C (3D)

Secondary accessions: D3DT31 O00558 Q5T5U5

Alternative splicing: 1 isoform: O00311-1

Explore the universe of human proteins at neXtProt for CDC7: NX_O00311

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00311

CDC7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001127891.1 NP_001127892.1 NP_003494.1

ENSEMBL proteins:

ENSP00000234626 ENSP00000398077 ENSP00000407477 ENSP00000393139

Reactome Protein details: O00311
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CDC7 OriGene Custom Protein Services for CDC7
	GenScript Custom Purified and Recombinant Proteins Services for CDC7
	Novus Biologicals CDC7 Protein Novus Biologicals CDC7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9250678
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	9250678

CDC7 for ontologies About GeneDecksing

CDC7 Antibody Products:

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	Cell Signaling Technology (CST) Antibodies for CDC7
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	Novus Biologicals CDC7 Antibodies
	Abcam antibodies for CDC7
	Uscn Antibodies for CDC7
	ThermoFisher Antibodies for CDC7

Assay Products for CDC7:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC7 for domains About GeneDecksing

4 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry O00311

ProtoNet protein and cluster: O00311

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDC7_HUMAN, O00311

Function: Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication.

Can phosphorylates MCM2 and MCM3

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		miRTarBase miRNAs that target CDC7: hsa-mir-192 (MIRT004845)

		OriGene 3'-UTR Clone (see all 3): CDC7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC7
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC7 (see all 20):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944

		SwitchGear 3'UTR luciferase reporter plasmid: CDC7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC7 (see all 7) OriGene shRNA RFP: CDC7 OriGene siRNA: CDC7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CDC7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC7 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC7 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CDC7 (NM_003503)
		Sino Biological Human cDNA Clone for CDC7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC7
		Search LifeMap BioReagents cell lines for CDC7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	IDA	9250678
GO:0046872	metal ion binding	IEA	--

CDC7 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CDC7:

Decreased focal adhesion (FA)	Decreased substrate adherent c	Decreased viability with RAF26	Paclitaxel antagonistic effect
Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Cdc7^tm1Hmas for CDC7
10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdc7):

cellular	embryogenesis	endocrine/exocrine gland	growth/size	homeostasis/metabolism
immune system	limbs/digits/tail	mortality/aging	normal	reproductive system

CDC7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

	DNA Replication Pre-Initiation	0.62			DNA Replication	0.49
	M/G1 Transition	0.62			Cell Cycle Checkpoints	0.42

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Activation of the pre-replicative complex

Activation of the pre-replicative complex

1.00

DNA Replication

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CDC7

	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 Cell Signaling Technology (CST) Pathway for CDC7

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for CDC7

Cell cycle Start of DNA replication in early S phase

2 BioSystems Pathways for CDC7

	Cell cycle
	DNA Replication

5/12 Reactome Pathways for CDC7 (see all 12)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	Cell Cycle
	M/G1 Transition

1 Kegg Pathway (Kegg details for CDC7):

Cell cycle

CDC7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/131 Interacting proteins for CDC7 (O00311^{2, 3} ENSP00000234626⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 131)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006260	DNA replication	TAS	--

CDC7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC7 for compounds About GeneDecksing

EMD Millipore small molecules for CDC7:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CDC7 available from Tocris Bioscience About this table

Compound	Action	CAS #
PHA 767491 hydrochloride	Dual cdc7/cdk9 inhibitor. Also inhibits MK-2	[845714-00-3]

2 HMDB Compounds for CDC7 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

4 Novoseek chemical compound relationships for CDC7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	51.5	10	10846177 (2), 17046832 (1), 18714392 (1), 11250080 (1) (see all 7)
serine	38.5	6	17046832 (1), 18714392 (1), 11441535 (1), 16864800 (1) (see all 6)
caffeine	16.4	1	15220931 (1)
alanine	13	3	17046832 (1), 16864800 (1), 10846177 (1)

Search CenterWatch for drugs/clinical trials and news about CDC7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC7 gene (3 alternative transcripts):

NM_001134419.1 NM_001134420.1 NM_003503.3

Unigene Cluster for CDC7:

Cell division cycle 7 homolog (S. cerevisiae)

Hs.533573 [show with all ESTs]

Unigene Representative Sequence: AB209337

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234626(uc001doe.3 uc001dof.3 uc010osw.2 uc009wdd.3)

ENST00000426137 ENST00000497611 ENST00000486509 ENST00000430031 ENST00000428239(uc009wdc.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CDC7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC7
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC7 (see all 20):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-30d hsa-miR-944

		SwitchGear 3'UTR luciferase reporter plasmid: CDC7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC7 (see all 7) OriGene shRNA RFP: CDC7 OriGene siRNA: CDC7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC7 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC7 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CDC7 (NM_003503)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC7

Additional cDNA sequence:

AB003698.1 AB209337.1 AF005209.1 AF015592.1 AK298963.1 AK312726.1 AY312583.1 BC110526.1

BC110527.1 BC111044.1

9 DOTS entries:

DT.314780 DT.92037489 DT.100812839 DT.99972354 DT.75164847 DT.121342092 DT.95364370 DT.97819446

DT.95124348

24/92 AceView cDNA sequences (see all 92):

BM789148 AL602215 AA429583 AU120443 N79336 BG170872 NM_003503 AY312583

AW574512 AA291015 D20593 BX409823 CB959717 BE551914 BU568048 AA814975

W76628 AW405542 AF005209 CN483945 BG116756 AL044123 AA345059 AI857674

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CDC7 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d
SP1:																					-				-
SP2:															-						-				-
SP3:																					-				-		-
SP4:																									-
SP5:

ECgene alternative splicing isoforms for CDC7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCATTTT

About this image

CDC7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC7

SOURCE GeneReport for Unigene cluster: Hs.533573

SABiosciences Custom PCR Arrays for CDC7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC7 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdc7^{1 , 5}	cell division cycle 7 (S. cerevisiae)^{1, 5}	83.21(n)¹ 81.43(a)¹		5 (51.43 cM)⁵ 12545¹ NM_009863.2¹ NP_033993.2¹ 106964322⁵
chicken (Gallus gallus)	Aves	CDC7¹	cell division cycle 7 homolog (S. cerevisiae)	73.99(n) 69.6(a)		424507 XM_422347.3 XP_422347.3
lizard (Anolis carolinensis)	Reptilia	CDC7⁶	--	66(a)	1 ↔ 1	4(94515057-94533957)
African clawed frog (Xenopus laevis)	Amphibia	Cdc7²	protein kinase Cdc7	76.41(n)		AF080068.1
zebrafish (Danio rerio)	Actinopterygii	Dr.20362²	Transcribed sequence with weak similarity to protein more	74.9(n)		57054035
fruit fly (Drosophila melanogaster)	Insecta	l(1)G0148¹	lethal (1) G0148	45.37(n) 39.59(a)		31598 NM_167080.1 NP_727103.1
worm (Caenorhabditis elegans)	Secernentea	cdc-7⁶	Protein CDC-7	24(a)	1 ↔ 1	I(5872177-5874345)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G16970¹	cell division control protein 7	41.32(n) 30.7(a)		827405 NM_117800.3 NP_193430.3
rice (Oryza sativa)	Liliopsida	--	protein kinase domain containing protein, expresse...	12(a)	1 ↔ 1	10(22176223-22181852)

ENSEMBL Gene Tree for CDC7 (if available)
TreeFam Gene Tree for CDC7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189801179^1,2		--	91964407(+)	`ATATCA/GTATAG`	2	--	us2k¹		0	--	--	--	--
rs182827742^1,2		--	91964431(+)	`TTCATC/TTATAA`	2	--	us2k¹		0	--	--	--	--
rs146827434^1,2		--	91964547(+)	`GTTAAC/TGACCT`	2	--	us2k¹		0	--	--	--	--
rs186987812^1,2		--	91964605(+)	`GTATTG/TCTTGT`	2	--	us2k¹		0	--	--	--	--
rs139240021^1,2		--	91964883(+)	`TAGGAG/TAAGGA`	3	--	us2k¹		0	--	--	--	--
rs143356050^1,2		--	91964919(+)	`GGCAAA/TGTTGA`	3	--	us2k¹		0	--	--	--	--
rs12717798^1,2	C,F,	--	91964946(+)	`ACATAT/CGATTA`	3	--	us2k¹		6		NS NA EA	424
rs13447448^1,2	C,F,	--	91964947(+)	`CATATG/AATTAT`	3	--	us2k¹		2		NS NA	300
rs12717799^1,2	C,F,H,	--	91964984(+)	`TATCAC/TGGTCA`	3	--	us2k¹		8		NS EA NA	724
rs565451^1,2	C,F,A,H,	--	91965131(-)	`AAAGCG/AGACCT`	3	--	us2k¹		23		NS EA NA WA CSA	1327

HapMap Linkage Disequilibrium report for CDC7 (91966404 - 91991321 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDC7
1 CNV: 97438

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC7 for disorders           About GeneDecksing

OMIM gene information: 603311    OMIM disorders: --

11 diseases for CDC7:    About MalaCards

ataxia telangiectasia glaucoma ataxia ovarian carcinoma

alzheimer's disease prostate cancer breast cancer prostatitis

melanoma carcinoma neuronitis

3 Novoseek disease relationships for CDC7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	39.6	2	16446360 (2)
cancer	2.98	7	18714392 (1), 17062569 (1), 19115845 (1), 15466207 (1) (see all 6)
tumors	2.83	13	18714392 (2), 19318489 (2), 19278428 (1), 15466207 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: CDC7 (3 documents)

Export disorders for CDC7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC7 gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with CDC7)

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Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. (PubMed id 9250678)^{1, 2, 3, 9} Sato N....Masai H. (1997)
Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (PubMed id 9405610)^{1, 2, 3, 9} Jiang W. and Hunter T. (1997)
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PubMed id 10373557)^{1, 2, 9} Kumagai H.... Masai H. (1999)
Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PubMed id 17062569)^{1, 2, 9} Tenca P....Santocanale C. (2007)
A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PubMed id 15668232)^{1, 2, 9} Yoshizawa-Sugata N....Masai H. (2005)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Drf1, a novel regulatory subunit for human Cdc7 kinase. (PubMed id 12065429)^{1, 2} Montagnoli A.... Santocanale C. (2002)
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. (PubMed id 9573348)^{1, 2} Hess G.F....Hollingsworth R.E. (1998)
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. (PubMed id 10846177)^{1, 9} Masai H....Arai K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8317	HGNC: 1745	AceView: CDC7	Ensembl:ENSG00000097046	euGenes: HUgn8317
ECgene: CDC7	Kegg: 8317	H-InvDB: CDC7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDC7	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc7/

Intellectual Property for CDC7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDC7 gene:
Search GeneIP for patents involving CDC7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cell division cycle 7

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