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Aliases for CDC6 Gene

Aliases for CDC6 Gene

  • Cell Division Cycle 6 2 3 5
  • Cdc18-Related Protein 3 4
  • CDC6-Related Protein 3 4
  • P62(Cdc6) 3 4
  • HsCDC18 3 4
  • CDC18L 3 4
  • HsCDC6 3 4
  • CDC6 (Cell Division Cycle 6, S. Cerevisiae) Homolog 2
  • CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 6 Homolog (S. Cerevisiae) 2
  • CDC6 Cell Division Cycle 6 Homolog 3
  • Cell Division Cycle 6 Homolog 3

External Ids for CDC6 Gene

Previous HGNC Symbols for CDC6 Gene

  • CDC18L

Previous GeneCards Identifiers for CDC6 Gene

  • GC17P037939
  • GC17P040619
  • GC17P038352
  • GC17P038817
  • GC17P035697
  • GC17P038443
  • GC17P034237

Summaries for CDC6 Gene

Entrez Gene Summary for CDC6 Gene

  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC6 Gene

CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include meier-gorlin syndrome 5 and meier-gorlin syndrome 1. Among its related pathways are Cell Cycle, Mitotic and Cell cycle. GO annotations related to this gene include nucleotide binding and kinase binding. An important paralog of this gene is ORC1.

UniProtKB/Swiss-Prot for CDC6 Gene

  • Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Gene Wiki entry for CDC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC6 Gene

Genomics for CDC6 Gene

Regulatory Elements for CDC6 Gene

Promoters for CDC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC6 Gene

Chromosome:
17
Start:
40,287,633 bp from pter
End:
40,304,657 bp from pter
Size:
17,025 bases
Orientation:
Plus strand

Genomic View for CDC6 Gene

Genes around CDC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC6 Gene

Proteins for CDC6 Gene

  • Protein details for CDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99741-CDC6_HUMAN
    Recommended name:
    Cell division control protein 6 homolog
    Protein Accession:
    Q99741
    Secondary Accessions:
    • Q8TB30

    Protein attributes for CDC6 Gene

    Size:
    560 amino acids
    Molecular mass:
    62720 Da
    Quaternary structure:
    • Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Interacts with ANKRD17.

    Three dimensional structures from OCA and Proteopedia for CDC6 Gene

neXtProt entry for CDC6 Gene

Proteomics data for CDC6 Gene at MOPED

Post-translational modifications for CDC6 Gene

  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC6 (CDC6)

No data available for DME Specific Peptides for CDC6 Gene

Domains & Families for CDC6 Gene

Protein Domains for CDC6 Gene

Suggested Antigen Peptide Sequences for CDC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99741

UniProtKB/Swiss-Prot:

CDC6_HUMAN :
  • Belongs to the CDC6/cdc18 family.
Family:
  • Belongs to the CDC6/cdc18 family.
genes like me logo Genes that share domains with CDC6: view

No data available for Gene Families for CDC6 Gene

Function for CDC6 Gene

Molecular function for CDC6 Gene

GENATLAS Biochemistry:
cell division cycle 6,S cerevisiae homolog,selectively expressed in proliferating but not quiescent cell,regulated by E2F proteins,required for the initiation of DNA replication ,ORC1 homolog
UniProtKB/Swiss-Prot Function:
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
genes like me logo Genes that share phenotypes with CDC6: view

Human Phenotype Ontology for CDC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDC6 Gene

MGI Knock Outs for CDC6:
  • Cdc6 tm1a(KOMP)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CDC6 Gene

Localization for CDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC6 Gene

Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC6 Gene COMPARTMENTS Subcellular localization image for CDC6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21041660
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC6: view

Pathways & Interactions for CDC6 Gene

genes like me logo Genes that share pathways with CDC6: view

SIGNOR curated interactions for CDC6 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint TAS 9566895
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9566895
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CDC6: view

Drugs & Compounds for CDC6 Gene

(2) Drugs for CDC6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CDC6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDC6: view

Transcripts for CDC6 Gene

Unigene Clusters for CDC6 Gene

Cell division cycle 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CDC6 Gene

GeneLoc Exon Structure for
CDC6
ECgene alternative splicing isoforms for
CDC6

Expression for CDC6 Gene

mRNA expression in normal human tissues for CDC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC6 Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for CDC6 Gene

This gene is overexpressed in Monocytes (38.4) and Tlymphocyte (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC6 Gene



SOURCE GeneReport for Unigene cluster for CDC6 Gene Hs.405958

genes like me logo Genes that share expression patterns with CDC6: view

Protein tissue co-expression partners for CDC6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDC6 Gene

Orthologs for CDC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC6 35
  • 89.88 (n)
  • 87.68 (a)
CDC6 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC6 35
  • 90.48 (n)
  • 89.59 (a)
CDC6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc6 35
  • 82.41 (n)
  • 80.5 (a)
Cdc6 16
Cdc6 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC6 35
  • 99.82 (n)
  • 99.64 (a)
CDC6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc6 35
  • 81.57 (n)
  • 80.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC6 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC6 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857489 35
  • 57.86 (n)
  • 57.14 (a)
CDC6 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC6 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc6 35
  • 63.33 (n)
  • 64.55 (a)
Str.8648 35
African clawed frog
(Xenopus laevis)
Amphibia Xcdc6 35
zebrafish
(Danio rerio)
Actinopterygii cdc6 35
  • 55.04 (n)
  • 53.54 (a)
Dr.3850 35
cdc6 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2444 35
fruit fly
(Drosophila melanogaster)
Insecta CG5971 37
  • 42 (a)
Cdc6 35
  • 50.76 (n)
  • 43.91 (a)
Cdc6 36
  • 31 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005176 35
  • 48.56 (n)
  • 43.51 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-6 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC6 36
  • 24 (a)
OneToMany
CDC6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC6 35
  • 44.75 (n)
  • 34.24 (a)
rice
(Oryza sativa)
Liliopsida Os01g0856000 35
  • 45.51 (n)
  • 32.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8705 36
  • 48 (a)
OneToOne
Species with no ortholog for CDC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC6 Gene

ENSEMBL:
Gene Tree for CDC6 (if available)
TreeFam:
Gene Tree for CDC6 (if available)

Paralogs for CDC6 Gene

Paralogs for CDC6 Gene

genes like me logo Genes that share paralogs with CDC6: view

Variants for CDC6 Gene

Sequence variations from dbSNP and Humsavar for CDC6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4135010 - 40,293,507(+) TGAGG(A/G)CTGCC reference, missense
rs4135012 - 40,293,996(+) GCCAG(A/G)ATGTA reference, missense
rs4135013 - 40,294,009(+) GTACA(C/T)GCTAT reference, missense
rs4135016 - 40,295,405(+) TGCCC(A/G)CAAAG reference, missense
rs13706 - 40,300,899(+) CAGAA(A/C/G)TTGAT reference, missense

Variation tolerance for CDC6 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.91; 89.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC6 Gene

HapMap Linkage Disequilibrium report
CDC6
Human Gene Mutation Database (HGMD)
CDC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDC6 Gene

Disorders for CDC6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CDC6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meier-gorlin syndrome 5
  • mgors5
meier-gorlin syndrome 1
  • meier-gorlin syndrome
cervical intraepithelial neoplasia
  • cin
microtia
- elite association - COSMIC cancer census association via MalaCards
Search CDC6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDC6_HUMAN
  • Meier-Gorlin syndrome 5 (MGORS5) [MIM:613805]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDC6

Genetic Association Database (GAD)
CDC6
Human Genome Epidemiology (HuGE) Navigator
CDC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC6
genes like me logo Genes that share disorders with CDC6: view

No data available for Genatlas for CDC6 Gene

Publications for CDC6 Gene

  1. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. (PMID: 9566895) Saha P. … Dutta A. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. (PMID: 20048340) Yoshida K. … Fujita M. (J. Cell. Sci. 2010) 3 23
  3. Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (PMID: 19101572) Xiong X.D. … Zhuang S.M. (Mutat. Res. 2009) 3 23
  4. Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. (PMID: 19107233) Wu Z. … Theodorescu D. (Neoplasia 2009) 3 23
  5. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M. … Ye X. (J. Biol. Chem. 2009) 3 23

Products for CDC6 Gene

Sources for CDC6 Gene

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