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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC6 Gene

protein-coding GIFtS: 64
GCID: GC17P038443

cell division cycle 6

(Previous names: CDC6 (cell division cycle 6, S. cerevisiae) homolog, CDC6...)
(Previous symbol: CDC18L)

Explore 31 diseases affiliated with
CDC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 6¹ ²		CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae)¹
CDC18L¹ ² ³ ⁵		Cell Division Cycle 6 Homolog (S. Cerevisiae)¹
Cdc18-Related Protein² ³		HsCDC18²
HsCDC6² ³		CDC6 Cell Division Cycle 6 Homolog²
CDC6-Related Protein² ³		Cell Division Control Protein 6 Homolog²
P62(Cdc6)¹		Cell Division Cycle 6 Homolog²
CDC6 (Cell Division Cycle 6, S. Cerevisiae) Homolog¹		HsCdc18³

External Ids:	HGNC: 1744¹	Entrez Gene: 990²	Ensembl: ENSG00000094804⁷	OMIM: 602627⁵	UniProtKB: Q99741³

Export aliases for CDC6 gene to outside databases

Previous GC identifers: GC17P037939 GC17P040619 GC17P038352 GC17P038817 GC17P035697 GC17P034237

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC6:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the

initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It

localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The

subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.

Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional

control mechanism involving E2F proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741

Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA

replication is completed before mitosis is initiated

Gene Wiki entry for CDC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC6 gene promoter:
c-Fos SRF AP-1 NRSF form 1 SRF (504 AA) Nkx2-5 NRSF form 2 HNF-4alpha1 c-Jun ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC6 promoter sequence

Search SABiosciences Chromatin IP Primers for CDC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.3

CDC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC6 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P038443: view genomic region (about GC identifiers)

Start:	38,443,885 bp from pter	End:	38,459,413 bp from pter
Size:	15,529 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741 (See protein sequence)

Recommended Name: Cell division control protein 6 homolog

Size: 560 amino acids; 62720 Da

Subunit: Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1

Subcellular location: Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells

2 PDB 3D structures from and Proteopedia for CDC6:

2CCH (3D)

2CCI (3D)

Secondary accessions: Q8TB30

Explore the universe of human proteins at neXtProt for CDC6: NX_Q99741

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99741

CDC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001245.1

ENSEMBL proteins:

ENSP00000209728 ENSP00000463635 ENSP00000463004 ENSP00000464047

Reactome Protein details: Q99741
Human Recombinant Protein Products for CDC6:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Custom Purified and Recombinant Proteins Services for CDC6
	Novus Biologicals CDC6 Proteins Novus Biologicals CDC6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC6

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	TAS	9566895
GO:0005819	spindle	--	--

CDC6 for ontologies About GeneDecksing

CDC6 Antibody Products:

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	Novus Biologicals CDC6 Antibodies
	Abcam antibodies for CDC6
	Uscn Antibodies for CDC6
	ThermoFisher Antibody for CDC6

Assay Products for CDC6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC6 for domains About GeneDecksing

4 InterPro domains/families:

IPR016314 Cell_div_Cdc6/18

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR003593 AAA+_ATPase

IPR015163 Cdc6_C_dom

Graphical View of Domain Structure for InterPro Entry Q99741

ProtoNet protein and cluster: Q99741

UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741

Similarity: Belongs to the CDC6/cdc18 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDC6_HUMAN, Q99741

Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA

replication is completed before mitosis is initiated

Genatlas biochemistry entry for CDC6:

cell division cycle 6,S cerevisiae homolog,selectively expressed in proliferating but not quiescent cell,regulated by

E2F proteins,required for the initiation of DNA replication ,ORC1 homolog

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	TAS	8990175
GO:0003682	chromatin binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0017111	nucleoside-triphosphatase activity	IEA	--

CDC6 for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for CDC6:

Decreased Wnt reporter activit	G2 arrest	Increased G2M DNA content	Increased cell death in breast
Increased cell number in S	Upregulation of Wnt/beta-caten

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cdc6):

mortality/aging

CDC6 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDC6

miRNA Products:		miRTarBase miRNAs that target CDC6: hsa-mir-26a (MIRT001022)

		OriGene 3'-UTR Clone: CDC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC6
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC6 (see all 13):
		hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-1297 hsa-miR-513b hsa-miR-23b hsa-miR-3115 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC6 (see all 7) OriGene shRNA RFP: CDC6 OriGene siRNA: CDC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC6
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDC6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CDC6
			Sirion Biotech Customized adenovirus for overexpression of CDC6 Sirion Biotech Customized adenovirus for potent knockdown of CDC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDC6 (NM_001254)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC6
		Search LifeMap BioReagents cell lines for CDC6
		Sirion Biotech Customized stable knockdown cell line services for CDC6 Sirion Biotech Customized inducible knockdown cell line services for CDC6 Sirion Biotech Customized stable overexpressing cell line services for CDC6 Sirion Biotech Customized inducible overexpressing cell line services for CDC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/14 pathways (see all 14)
Ubiquitinated Cdc6 is degraded by the proteasome	0.96	Removal of licensing factors from origins	0.68
CDK-mediated phosphorylation and removal of Cdc6	0.94	DNA Replication Pre-Initiation	0.62
CDT1 association with the CDC6:ORC:origin complex	0.84	M/G1 Transition	0.62
Assembly of the pre-replicative complex	0.77	Synthesis of DNA	0.51

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

CDC6 association with the ORC:origin complex

CDC6 association with the ORC:origin complex

1.00

Association of licensing factors with the pre-replicative complex

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CDC6

	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Start of DNA replication in early S phase

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC6

	Factors Promoting Cardiogenesis in Vertebrates
	Cell Cycle Control of Chromosomal Replication

1 Cell Signaling Technology (CST) Pathway for CDC6

Cell Cycle / Checkpoint Control

2 GeneGo (Thomson Reuters) Pathways for CDC6

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for CDC6

	Cell cycle
	DNA Replication
	E2F transcription factor network

5/30 Reactome Pathways for CDC6 (see all 30)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	G0 and Early G1
	Removal of licensing factors from origins

1 Kegg Pathway (Kegg details for CDC6):

Cell cycle

CDC6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/194 Interacting proteins for CDC6 (Q99741^{1, 2, 3} ENSP00000209728⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 194)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000076	DNA replication checkpoint	TAS	9566895
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	9566895
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS	--

CDC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC6
6 Novoseek chemical compound relationships for CDC6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
se-methylselenocysteine	67.1	3	15213307 (1), 16518418 (1), 16535772 (1)
sn 38	48.2	2	15213307 (1), 16535772 (1)
atpgammas	32.4	2	11737877 (1)
atp	17	11	16387651 (6), 14506278 (2), 20139730 (1), 11737877 (1)
oligonucleotide	0	2	12384698 (1)
etoposide	0	3	14517333 (1), 16801388 (1)

Search CenterWatch for drugs/clinical trials and news about CDC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC6 gene:

NM_001254.3

Unigene Cluster for CDC6:

Cell division cycle 6 homolog (S. cerevisiae)

Hs.405958 [show with all ESTs]

Unigene Representative Sequence: NM_001254

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000209728(uc002huj.1) ENST00000580824 ENST00000577249 ENST00000473555

ENST00000582402

miRNA Products:		OriGene 3'-UTR Clone: CDC6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC6
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC6 (see all 13):
		hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-1297 hsa-miR-513b hsa-miR-23b hsa-miR-3115 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC6 (see all 7) OriGene shRNA RFP: CDC6 OriGene siRNA: CDC6
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CDC6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDC6 (NM_001254)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC6

Additional cDNA sequence:

AF022109.1 AK313620.1 BC025232.1 U77949.1

10 DOTS entries:

DT.444451 DT.100749845 DT.100035643 DT.95272820 DT.120902080 DT.120902193 DT.75101780 DT.95272818

DT.99933270 DT.120902197

24/133 AceView cDNA sequences (see all 133):

BU619893 AA836395 BM465884 BP336518 BX956287 BP364218 BE550416 CR598029

BQ070080 BP870473 BQ064897 BU846236 BQ675107 CA429634 NM_001254 BM836937

BQ775002 BQ228599 BC025232 AI341585 BU620637 CA429336 BE548194 AA356355

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC6 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:							-		-
SP2:					-		-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for CDC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CDC6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC6

SOURCE GeneReport for Unigene cluster: Hs.405958

SABiosciences Expression via Pathway-Focused PCR Arrays including CDC6:

Cell Cycle in human mouse rat

TGFB Signaling Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC6 gene from 7/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CDC6⁶	--	57(a)	1 ↔ 1	6(69633185-69652289)
African clawed frog (Xenopus laevis)	Amphibia	Xcdc6²	Cdc6-related protein	75.46(n)		U66558.1
zebrafish (Danio rerio)	Actinopterygii	Dr.3850²	Danio rerio cDNA clone IMAGE6797233, partial cds	70.99(n)		BC056313.1
fruit fly (Drosophila melanogaster)	Insecta	CG5971³ Cdc6¹	pre-replicative complex formation and maintenance more³ CG5971-PA¹	42(a)³ 49.06(n)¹ 41.09(a)¹		66D9³ 38989¹ NM_139990.2¹ NP_648247.1¹
worm (Caenorhabditis elegans)	Secernentea	cdc-6¹	Protein CDC-6	42.68(n) 32.74(a)		172029 NM_058942.4 NP_491343.1
thale cress (Arabidopsis thaliana)	eudicotyledons	CDC6¹	cell division control 6	43.63(n) 33.88(a)		817518 NM_179806.1 NP_850137.1
rice (Oryza sativa)	Liliopsida	Os01g0856000¹	hypothetical protein	45.61(n) 32.86(a)		4324832 NM_001051380.1 NP_001044845.2

ENSEMBL Gene Tree for CDC6 (if available)
TreeFam Gene Tree for CDC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDC6 gene

ORC1²

CDC6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142169111^1,2		--	38442303(+)	`CAGTGA/TAGGTT`	1	--	us2k¹		0	--	--	--	--
rs116685022^1,2	C,F	--	38442323(+)	`GTTCTA/GCTATC`	1	--	us2k¹		1		WA	118
rs181196543^1,2		--	38442524(+)	`GGTGAC/TGCGTG`	1	--	us2k¹		0	--	--	--	--
rs114377359^1,2	F	--	38442642(+)	`TAAAAT/CGAGAC`	1	--	us2k¹		1		WA	118
rs184101425^1,2		--	38442879(+)	`CTTCCA/GCTTAC`	1	--	us2k¹		0	--	--	--	--
rs118187435^1,2		--	38442967(+)	`GGTTCA/GTGGGG`	1	--	us2k¹		1		EA	120
rs145912053^1,2		--	38443191(+)	`TTCTGA/GCCTCT`	1	--	us2k¹		0	--	--	--	--
rs188883147^1,2		--	38443255(+)	`TACTGC/TGCTAA`	1	--	us2k¹		0	--	--	--	--
rs7502908^1,2	H	--	38443303(+)	`ATATAG/CCTGTC`	1	--	us2k¹		4		NS EA	386
rs181419826^1,2		--	38443341(+)	`CGCCAC/TAAAAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDC6 (38443885 - 38459413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC6: --
Human Gene Mutation Database (HGMD): CDC6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC6 for disorders About GeneDecksing

OMIM gene information: 602627 OMIM disorders: --

UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741

Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:613805]. MGORS5 is a syndrome

characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth

retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial

sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate,

micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial

dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and

absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal

20/31 diseases for CDC6 (see all 31): About MalaCards

meier-gorlin syndrome intrauterine and postnatal growth retardation cervical intraepithelial neoplasia non-hodgkin lymphoma

short stature oral squamous cell carcinoma mantle cell lymphoma squamous cell carcinoma

microtia hodgkin's lymphoma chronic lymphocytic leukemia cervicitis

lymphocytic leukemia dwarfism hepatocellular carcinoma cervical cancer

carcinoma microcephaly prostate cancer copd

10/13 Novoseek disease relationships for CDC6 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cervical dysplasia	33.8	1	15696126 (1)
cancer	28.1	7	20079629 (1), 16572177 (1), 18259842 (1), 12718885 (1) (see all 5)
cervical intraepithelial neoplasia	26	4	15696126 (2), 12296751 (1), 15858126 (1)
cervical cancer	23.6	2	15858126 (1), 19950599 (1)
tumors	20.8	26	15858126 (3), 19102762 (3), 11496317 (2), 14517333 (1) (see all 11)
carcinoma squamous cell	13.4	5	15858126 (2), 15696126 (2), 12296751 (1)
prostate cancer	9.66	14	19520769 (4), 18541154 (4), 19107233 (2), 15887248 (1)
dysplasia	7.35	8	12296751 (2), 19116018 (2), 15858126 (1)
lung carcinoma	5.1	1	16572177 (1)
necrosis	0	3	14517333 (1), 16801388 (1)

Human Genome Epidemiology (HuGE) Navigator: CDC6 (8 documents)

Export disorders for CDC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC6 gene, integrated from 9 sources (see all 203):
(articles sorted by number of sources associating them with CDC6)

Utopia: connect your pdf to the dynamic
world of online information

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. (PubMed id 9566895)^{1, 2, 3} Saha P.... Dutta A. (1998)
A human protein related to yeast Cdc6p. (PubMed id 8990175)^{1, 2, 3} Williams R.S.... Stillman B. (1997)
Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)^{1, 2} Bicknell L.S....Jackson A.P. (2011)
Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. (PubMed id 17567951)^{1, 2} Hall J.R....Cook J.G. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cdc6 knockdown inhibits human neuroblastoma cell proliferation. (PubMed id 18259842)^{1, 9} Feng L....Jong A. (2008)
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. (PubMed id 9889196)^{1, 9} Petersen B.O....Helin K. (1999)
ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells. (PubMed id 19154794)^{1, 9} Liu L....Lee S.K. (2009)
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. (PubMed id 10995389)^{1, 9} Petersen B.O....Helin K. (2000)
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. (PubMed id 10339564)^{1, 9} Jiang W....Hunter T. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 990	HGNC: 1744	AceView: CDC6	Ensembl:ENSG00000094804	euGenes: HUgn990
ECgene: CDC6	Kegg: 990	H-InvDB: CDC6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDC6	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc6/

Intellectual Property for CDC6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDC6 gene:
Search GeneIP for patents involving CDC6

GeneCards and IP:
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cell division cycle 6

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cell division cycle 6

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