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CDC6 Gene

protein-coding   GIFtS: 65
GCID: GC17P038443

Cell Division Cycle 6

(Previous names: CDC6 (cell division cycle 6, S. cerevisiae) homolog, CDC6...)
(Previous symbol: CDC18L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 61 2     CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae)1
CDC18L1 2 3 5     Cell Division Cycle 6 Homolog (S. Cerevisiae)1
Cdc18-Related Protein2 3     HsCDC182
HsCDC62 3     CDC6 Cell Division Cycle 6 Homolog2
CDC6-Related Protein2 3     Cell Division Control Protein 6 Homolog2
p62(cdc6)2 3     Cell Division Cycle 6 Homolog2
CDC6 (Cell Division Cycle 6, S. Cerevisiae) Homolog1     HsCdc183

External Ids:    HGNC: 17441   Entrez Gene: 9902   Ensembl: ENSG000000948047   OMIM: 6026275   UniProtKB: Q997413   

Export aliases for CDC6 gene to outside databases

Previous GC identifers: GC17P037939 GC17P040619 GC17P038352 GC17P038817 GC17P035697 GC17P034237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC6 Gene:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the
initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It
localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The
subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.
Transcription of this protein was reported to be regulated in response to mitogenic signals through
transcriptional control mechanism involving E2F proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC6 Gene:
CDC6 (cell division cycle 6) is a protein-coding gene. Diseases associated with CDC6 include meier-gorlin syndrome 5, and meier-gorlin syndrome 1. GO annotations related to this gene include kinase binding and chromatin binding. An important paralog of this gene is ORC1.

UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741
Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA
replication is completed before mitosis is initiated

Gene Wiki entry for CDC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC6 gene promoter:
         c-Fos   SRF   AP-1   NRSF form 1   SRF (504 AA)   Nkx2-5   NRSF form 2   HNF-4alpha1   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC6 promoter sequence
   Search Chromatin IP Primers for CDC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.3

CDC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038443:  view genomic region     (about GC identifiers)

Start:
38,443,885 bp from pter      End:
38,459,413 bp from pter
Size:
15,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741 (See protein sequence)
Recommended Name: Cell division control protein 6 homolog  
Size: 560 amino acids; 62720 Da
Subunit: Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1
4 PDB 3D structures from and Proteopedia for CDC6:
2CCH (3D)        2CCI (3D)        4I5L (3D)        4I5N (3D)    
Secondary accessions: Q8TB30

Explore the universe of human proteins at neXtProt for CDC6: NX_Q99741

Explore proteomics data for CDC6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208
  • Modification sites at PhosphoSitePlus

  • See CDC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001245.1  
    ENSEMBL proteins: 
     ENSP00000209728   ENSP00000463635   ENSP00000463004   ENSP00000464047  
    Reactome Protein details: Q99741

    CDC6 Human Recombinant Protein Products:

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    Novus Biologicals CDC6 Proteins
    Novus Biologicals CDC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CDC6

    CDC6 Antibody Products:

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    CDC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CDC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC6
    Cloud-Clone Corp. CLIAs for CDC6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR016314 Cell_div_Cdc6/18
     IPR011991 WHTH_DNA-bd_dom
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR015163 Cdc6_C_dom

    Graphical View of Domain Structure for InterPro Entry Q99741

    ProtoNet protein and cluster: Q99741

    UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741
    Similarity: Belongs to the CDC6/cdc18 family


    CDC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC6_HUMAN, Q99741
    Function: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA
    replication is completed before mitosis is initiated

         Genatlas biochemistry entry for CDC6:
    cell division cycle 6,S cerevisiae homolog,selectively expressed in proliferating but not quiescent cell,regulated
    by E2F proteins,required for the initiation of DNA replication ,ORC1 homolog

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS8990175
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI14672932
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    CDC6 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDC6:
     Decreased Wnt reporter activit  G2 arrest  Increased G2M DNA content  Increased cell death in breast 
     Increased cell number in S  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cdc6):
     mortality/aging 

    CDC6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC6:
    hsa-mir-361-3p (MIRT038272), hsa-mir-501-5p (MIRT041141), hsa-mir-615-3p (MIRT040157), hsa-mir-142-3p (MIRT021602), hsa-mir-193b-3p (MIRT016523), hsa-mir-26a-5p (MIRT001022)

    Block miRNA regulation of human, mouse, rat CDC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC6 (see all 13):
    hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-1297 hsa-miR-513b hsa-miR-23b hsa-miR-3115 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC6
    Predesigned siRNA for gene silencing in human, mouse, rat CDC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC6

    Clone
    Products:
         
    OriGene clones in human, mouse for CDC6 (see all 6)
    OriGene ORF clones in mouse, rat for CDC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDC6 (NM_001254)
    Sino Biological Human cDNA Clone for CDC6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC6_HUMAN, Q99741: Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4
    golgi apparatus3

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CDC6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC6 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Removal of licensing factors from origins0.86
    Switching of origins to a post-replicative state0.93
    M/G1 Transition0.81
    Orc1 removal from chromatin0.93
    DNA Replication Pre-Initiation0.81
    Regulation of DNA replication0.93
    S Phase0.78
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    E2F mediated regulation of DNA replication0.30
    Mitotic G1-G1/S phases0.81
    G1/S-Specific Transcription0.00
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC6
        Factors Promoting Cardiogenesis in Vertebrates
    Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for CDC6
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDC6
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for CDC6
        Cell cycle
    DNA Replication
    E2F transcription factor network


    Selected Reactome Pathways for CDC6 (see all 12)
        Activation of ATR in response to replication stress
    G0 and Early G1
    Removal of licensing factors from origins
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6


    1 Kegg Pathway  (Kegg details for CDC6):
        Cell cycle


    CDC6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC6: 
              Cell Cycle in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC6 (Q997411, 2, 3 ENSP000002097284) via UniProtKB, MINT, STRING, and/or I2D (see all 424)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=2 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=2 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=2 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint TAS9566895
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS9566895
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    CDC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC6

    6 Novoseek inferred chemical compound relationships for CDC6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    se-methylselenocysteine 67.1 3 15213307 (1), 16518418 (1), 16535772 (1)
    sn 38 48.2 2 15213307 (1), 16535772 (1)
    atpgammas 32.4 2 11737877 (1)
    atp 17 11 16387651 (6), 14506278 (2), 20139730 (1), 11737877 (1)
    oligonucleotide 0 2 12384698 (1)
    etoposide 0 3 14517333 (1), 16801388 (1)



    CDC6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC6 gene: 
    NM_001254.3  

    Unigene Cluster for CDC6:

    Cell division cycle 6
    Hs.405958  [show with all ESTs]
    Unigene Representative Sequence: NM_001254
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209728(uc002huj.1) ENST00000580824 ENST00000577249 ENST00000473555
    ENST00000582402
    miRNA
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    Block miRNA regulation of human, mouse, rat CDC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC6 (see all 13):
    hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-1297 hsa-miR-513b hsa-miR-23b hsa-miR-3115 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDC6
    Predesigned siRNA for gene silencing in human, mouse, rat CDC6
    Clone
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    OriGene ORF clones in mouse, rat for CDC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDC6 (NM_001254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC6
    Primer
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    OriGene qPCR primer pairs and template standards for CDC6
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC6
      QuantiTect SYBR Green Assays in human, mouse, rat CDC6
      QuantiFast Probe-based Assays in human, mouse, rat CDC6

    Additional mRNA sequence: 

    AF022109.1 AK313620.1 BC025232.1 U77949.1 

    10 DOTS entries:

    DT.444451  DT.100749845  DT.100035643  DT.95272820  DT.120902080  DT.120902193  DT.75101780  DT.95272818 
    DT.99933270  DT.120902197 

    Selected AceView cDNA sequences (see all 133):

    CA488634 AA584340 BE907412 BU846236 NM_001254 BM465884 CA429634 BU619893 
    BM464160 AA356355 CA429336 AI341585 BX956287 BE550416 BQ675107 BQ775002 
    BP364218 BU633837 BQ064897 BM836937 BQ228599 CR598029 BQ070080 BU620637 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC6    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -     -                                                                                       
    SP2:              -     -     -                                                                                       
    SP3:                          -                                                                                       
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for CDC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDC6 Expression
    About this image


    CDC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Endothelial Cells Blood Brain Barrier
             Globus Pallidus
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    CDC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405958
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC6: 
              Cell Cycle in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDC6
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC6
    QuantiTect SYBR Green Assays in human, mouse, rat CDC6
    QuantiFast Probe-based Assays in human, mouse, rat CDC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC6 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc61 , 5 cell division cycle 6 homolog (S. cerevisiae)5
    cell division cycle 61
    82.41(n)1
    80.5(a)1
      11 (62.74 cM)5
    238341  NM_001025779.11  NP_001020950.11 
     989078015 
    chicken
    (Gallus gallus)
    Aves LOC1008574891 cell division control protein 6 homolog 57.86(n)
    57.14(a)
      100857489  XM_004948643.1  XP_004948700.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC66
    cell division cycle 6
    61(a)
    1 ↔ 1
    6(69630079-69653624)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xcdc62 Cdc6-related protein 75.46(n)    U66558.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.38502 Danio rerio cDNA clone IMAGE6797233, partial cds 70.99(n)    BC056313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59713
    Cdc61
    pre-replicative complex formation and
    maintenance more3
    Cdc61
    42(a)3
    50.76(n)1
    43.91(a)1
      66D93
    389891  NM_139990.31  NP_648247.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-66
    Protein CDC-6 (cdc-6) mRNA, complete cds
    25(a)
    1 ↔ 1
    I(4268069-4270287) WBGene00000382
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC6(YJL194W)4 Essential ATP-binding protein required for DNA replication, more   --   10(69338-70879) 853244  NP_012341.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDC61 CDC6 44.75(n)
    34.24(a)
      817518  NM_179806.1  NP_850137.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08560001 Os01g0856000 45.51(n)
    32.86(a)
      4324832  NM_001051380.1  NP_001044845.2 


    ENSEMBL Gene Tree for CDC6 (if available)
    TreeFam Gene Tree for CDC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC6 gene
    ORC12  

    CDC6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDC6 (see all 344)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654934
    Meier-Gorlin syndrome 5 (MGORS5)4--see VAR_0654932 T R mis40--------
    rs41350051,2
    C,F--38448383(+) tcttgG/Tgctca 1 -- int11Minor allele frequency- T:0.01NS 180
    rs41350061,2
    C,F--38448406(+) acctcG/Agcctc 1 -- int12Minor allele frequency- A:0.02NS WA 298
    rs41350071,2
    C,F--38448552(+) ctgggA/Gttaca 1 -- int11Minor allele frequency- G:0.01NS 180
    rs58203441,2
    C--38454649(+) TTTTTT/-CTTTT 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs671629651,2
    C--38455391(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2011840751,2
    C--38456003(+) AAAAAA/GAAAAA 1 -- int10--------
    rs713000551,2
    C--38456004(-) ACCATT/-CTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2015100721,2
    C--38456021(-) ACCATC/TTTTTT 1 -- int10--------
    rs1421691111,2
    --39229238(+) CAGTGA/TAGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC6 (38443885 - 38459413 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDC6: --
    Human Gene Mutation Database (HGMD): CDC6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC6
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602627   
    OMIM disorders: 613805  
    UniProtKB/Swiss-Prot: CDC6_HUMAN, Q99741
  • Meier-Gorlin syndrome 5 (MGORS5) [MIM:613805]: A syndrome characterized by bilateral microtia,
    aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature
    and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently
    low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract
    anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial
    prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic
    patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • Selected diseases for CDC6 (see all 36):    
    About MalaCards
    meier-gorlin syndrome 5    meier-gorlin syndrome 1    meier-gorlin syndrome    cervical intraepithelial neoplasia
    microtia    dwarfism    cervical cancer    cervicitis
    mantle cell lymphoma    microcephaly    short stature    cleft palate
    oral squamous cell carcinoma    non-hodgkin lymphoma    hodgkin's lymphoma    hepatocellular carcinoma
    chronic lymphocytic leukemia    prostate cancer    hypoxia    squamous cell carcinoma


    CDC6 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CDC6 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical dysplasia 33.8 1 15696126 (1)
    cancer 28.1 7 20079629 (1), 16572177 (1), 18259842 (1), 12718885 (1) (see all 5)
    cervical intraepithelial neoplasia 26 4 15696126 (2), 12296751 (1), 15858126 (1)
    cervical cancer 23.6 2 15858126 (1), 19950599 (1)
    tumors 20.8 26 15858126 (3), 19102762 (3), 11496317 (2), 14517333 (1) (see all 11)
    carcinoma squamous cell 13.4 5 15858126 (2), 15696126 (2), 12296751 (1)
    prostate cancer 9.66 14 19520769 (4), 18541154 (4), 19107233 (2), 15887248 (1)
    dysplasia 7.35 8 12296751 (2), 19116018 (2), 15858126 (1)
    lung carcinoma 5.1 1 16572177 (1)
    necrosis 0 3 14517333 (1), 16801388 (1)

    Genetic Association Database (GAD): CDC6
    Human Genome Epidemiology (HuGE) Navigator: CDC6 (8 documents)

    Export disorders for CDC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC6 gene, integrated from 10 sources (see all 214):
    (articles sorted by number of sources associating them with CDC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. (PubMed id 9566895)1, 2, 3 Saha P.... Dutta A. (Mol. Cell. Biol. 1998)
    2. A human protein related to yeast Cdc6p. (PubMed id 8990175)1, 2, 3 Williams R.S.... Stillman B. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD. (PubMed id 19233139)1, 4, 9 Takabatake N....Kubota I. (Biochem. Biophys. Res. Commun. 2009)
    4. Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (PubMed id 19101572)1, 4, 9 Xiong X.D....Zhuang S.M. (Mutat. Res. 2009)
    5. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)1, 2 Bicknell L.S....Jackson A.P. (Nat. Genet. 2011)
    6. Association between the CDC6 G1321A polymorphism and the risk of cervical cancer. (PubMed id 20606534)1, 4 Xiong X.D....Liu X.G. (Int. J. Gynecol. Cancer 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. A novel functional polymorphism in the Cdc6 promoter is associated with the risk for hepatocellular carcinoma. (PubMed id 18640135)1, 4 Xiong X.D....Zhuang S.M. (Mutat. Res. 2008)
    9. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    10. Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. (PubMed id 17567951)1, 2 Hall J.R....Cook J.G. (Mol. Biol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 990 HGNC: 1744 AceView: CDC6 Ensembl:ENSG00000094804 euGenes: HUgn990
    ECgene: CDC6 Kegg: 990 H-InvDB: CDC6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC6 gene:
    Search GeneIP for patents involving CDC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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