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Aliases for CDC5L Gene

Aliases for CDC5L Gene

  • Cell Division Cycle 5 Like 2 3 5
  • Pombe Cdc5-Related Protein 3 4
  • PCDC5RP 3 4
  • CDC5 (Cell Division Cycle 5, S. Pombe, Homolog)-Like 2
  • CDC5 Cell Division Cycle 5-Like (S. Pombe) 2
  • CDC5 Cell Division Cycle 5-Like 3
  • DJ319D22.1 (CDC5-Like Protein) 3
  • Cell Division Cycle 5-Like 2
  • Cdc5-Related Protein 3
  • Cdc5-Like Protein 4
  • DJ319D22.1 3
  • CDC5-LIKE 3
  • KIAA0432 4
  • CDC5 3
  • CEF1 3

External Ids for CDC5L Gene

Previous GeneCards Identifiers for CDC5L Gene

  • GC06P044357
  • GC06P044402
  • GC06P044463
  • GC06P044078

Summaries for CDC5L Gene

Entrez Gene Summary for CDC5L Gene

  • The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC5L Gene

CDC5L (Cell Division Cycle 5 Like) is a Protein Coding gene. Diseases associated with CDC5L include renal dysplasia and cystoisosporiasis. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and chromatin binding.

UniProtKB/Swiss-Prot for CDC5L Gene

  • DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Wiki entry for CDC5L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC5L Gene

Genomics for CDC5L Gene

Regulatory Elements for CDC5L Gene

Promoters for CDC5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC5L on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC5L Gene

Chromosome:
6
Start:
44,387,514 bp from pter
End:
44,450,426 bp from pter
Size:
62,913 bases
Orientation:
Plus strand

Genomic View for CDC5L Gene

Genes around CDC5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC5L Gene

Proteins for CDC5L Gene

  • Protein details for CDC5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99459-CDC5L_HUMAN
    Recommended name:
    Cell division cycle 5-like protein
    Protein Accession:
    Q99459
    Secondary Accessions:
    • Q76N46
    • Q99974

    Protein attributes for CDC5L Gene

    Size:
    802 amino acids
    Molecular mass:
    92251 Da
    Quaternary structure:
    • Homodimer. Interacts with DAPK3 (By similarity). Belongs to the spliceosome complex. Part of a spliceosomal core complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1. Interacts with PRPF19 (via N-terminus) (By similarity).
    SequenceCaution:
    • Sequence=BAA24862.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC5L Gene

neXtProt entry for CDC5L Gene

Proteomics data for CDC5L Gene at MOPED

Post-translational modifications for CDC5L Gene

  • Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC5L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDC5L Gene

Domains & Families for CDC5L Gene

Gene Families for CDC5L Gene

Protein Domains for CDC5L Gene

Suggested Antigen Peptide Sequences for CDC5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99459

UniProtKB/Swiss-Prot:

CDC5L_HUMAN :
  • Contains 2 HTH myb-type DNA-binding domains.
  • Belongs to the CEF1 family.
Domain:
  • Contains 2 HTH myb-type DNA-binding domains.
Family:
  • Belongs to the CEF1 family.
genes like me logo Genes that share domains with CDC5L: view

Function for CDC5L Gene

Molecular function for CDC5L Gene

GENATLAS Biochemistry:
protein,homolog to yeast CDC5-like-sequence,Myb-related,nuclear protein localizing in the nuclear speckles colocalizing,associating with core complements of the splicing machinery in nuclear extracts and interacting with the spliceoform,required for the pre-mRNA splicing,involved in the cell cycle essential for G2/M progression,disrupted in translocation t(6;19) (p21;q13.1) with multicystic renal dysplasia (see also PUJO) ubiquitously expressed in adult and fetal tissue
UniProtKB/Swiss-Prot Function:
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Ontology (GO) - Molecular Function for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding IEA --
GO:0019901 protein kinase binding IEA --
GO:0043522 leucine zipper domain binding IEA --
genes like me logo Genes that share ontologies with CDC5L: view
genes like me logo Genes that share phenotypes with CDC5L: view

Animal Model Products

miRNA for CDC5L Gene

miRTarBase miRNAs that target CDC5L

Transcription Factor Targets for CDC5L Gene

Selected GeneGlobe predicted Target genes for CDC5L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for CDC5L Gene

Localization for CDC5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC5L Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269 PubMed:9038199}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC5L Gene COMPARTMENTS Subcellular localization image for CDC5L gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IDA 20176811
GO:0005737 cytoplasm IDA 9038199
GO:0016607 nuclear speck IEA,IDA 16332694
genes like me logo Genes that share ontologies with CDC5L: view

Pathways & Interactions for CDC5L Gene

genes like me logo Genes that share pathways with CDC5L: view

Pathways by source for CDC5L Gene

Gene Ontology (GO) - Biological Process for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0044344 cellular response to fibroblast growth factor stimulus IEA --
GO:0072422 signal transduction involved in DNA damage checkpoint IMP 24332808
GO:1904568 cellular response to wortmannin IEA --
genes like me logo Genes that share ontologies with CDC5L: view

No data available for SIGNOR curated interactions for CDC5L Gene

Drugs & Compounds for CDC5L Gene

(1) Drugs for CDC5L Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
genes like me logo Genes that share compounds with CDC5L: view

Transcripts for CDC5L Gene

mRNA/cDNA for CDC5L Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(248) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC5L Gene

Cell division cycle 5-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC5L Gene

No ASD Table

Relevant External Links for CDC5L Gene

GeneLoc Exon Structure for
CDC5L
ECgene alternative splicing isoforms for
CDC5L

Expression for CDC5L Gene

mRNA expression in normal human tissues for CDC5L Gene

Protein differential expression in normal tissues from HIPED for CDC5L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4) and Synovial fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC5L Gene



SOURCE GeneReport for Unigene cluster for CDC5L Gene Hs.485471

mRNA Expression by UniProt/SwissProt for CDC5L Gene

Q99459-CDC5L_HUMAN
Tissue specificity: Ubiquitously expressed in both fetal and adult tissues.
genes like me logo Genes that share expression patterns with CDC5L: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDC5L Gene

Orthologs for CDC5L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC5L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC5L 35
  • 93.81 (n)
  • 98.88 (a)
CDC5L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC5L 35
  • 94.18 (n)
  • 99 (a)
CDC5L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc5l 35
  • 89.69 (n)
  • 98 (a)
Cdc5l 16
Cdc5l 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC5L 35
  • 96.63 (n)
  • 96.01 (a)
CDC5L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc5l 35
  • 89.65 (n)
  • 97.88 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDC5L 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC5L 35
  • 80.9 (n)
  • 91.89 (a)
CDC5L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC5L 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc5l 35
  • 75.87 (n)
  • 86.87 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cdc5l 35
  • 71.37 (n)
  • 84.25 (a)
cdc5l 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7318 35
fruit fly
(Drosophila melanogaster)
Insecta CG6905 37
  • 62 (a)
CG6905 35
  • 60.08 (n)
  • 66.11 (a)
CG6905 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002954 35
  • 58.05 (n)
  • 66.37 (a)
worm
(Caenorhabditis elegans)
Secernentea D1081.8 35
  • 57.38 (n)
  • 54.29 (a)
D1081.8 36
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEF1 36
  • 34 (a)
OneToOne
CEF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC5 35
  • 54.64 (n)
  • 48.64 (a)
rice
(Oryza sativa)
Liliopsida Os04g0348300 35
  • 55.78 (n)
  • 52.07 (a)
corn
(Zea mays)
Liliopsida Zm.9391 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06994 35
  • 51.55 (n)
  • 48.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc5 35
  • 53.41 (n)
  • 47.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9863 36
  • 63 (a)
OneToOne
Species with no ortholog for CDC5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC5L Gene

ENSEMBL:
Gene Tree for CDC5L (if available)
TreeFam:
Gene Tree for CDC5L (if available)

Paralogs for CDC5L Gene

No data available for Paralogs for CDC5L Gene

Variants for CDC5L Gene

Sequence variations from dbSNP and Humsavar for CDC5L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11572006 - 44,422,781(+) AGACT(A/G)TAGTG nc-transcript-variant, reference, missense
rs487711 -- 44,430,146(+) AGAGT(C/G)CCCTG intron-variant
rs475426 -- 44,441,241(+) atatg(A/G)tattt intron-variant
rs526851 -- 44,436,334(+) CTGAA(A/G)TTTTA intron-variant
rs548342 -- 44,433,564(+) TGTCA(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC5L Gene

Variant ID Type Subtype PubMed ID
esv1198309 CNV Deletion 17803354
nsv885858 CNV Gain+Loss 21882294
nsv885859 CNV Loss 21882294
nsv517370 CNV Gain+Loss 19592680

Variation tolerance for CDC5L Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC5L Gene

HapMap Linkage Disequilibrium report
CDC5L
Human Gene Mutation Database (HGMD)
CDC5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC5L Gene

Disorders for CDC5L Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDC5L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal dysplasia
  • renal cell dysplasia
cystoisosporiasis
  • infection by isospora belli and isospora hominis
poikiloderma with neutropenia
  • clericuzio type poikiloderma with neutropenia
- elite association - COSMIC cancer census association via MalaCards
Search CDC5L in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDC5L_HUMAN
  • Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.

Relevant External Links for CDC5L

Genetic Association Database (GAD)
CDC5L
Human Genome Epidemiology (HuGE) Navigator
CDC5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC5L
genes like me logo Genes that share disorders with CDC5L: view

No data available for Genatlas for CDC5L Gene

Publications for CDC5L Gene

  1. Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. (PMID: 9598309) Groenen P.M.A. … Van de Ven W.J.M. (Genomics 1998) 2 3 4 23 67
  2. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. (PMID: 9038199) Bernstein H.S. … Coughlin S.R. (J. Biol. Chem. 1997) 2 3 23
  3. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. (PMID: 18583928) Graub R. … Bernstein H.S. (Cell Cycle 2008) 3 23
  4. The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. (PMID: 16223718) Zhang N. … Legerski R.J. (J. Biol. Chem. 2005) 3 23
  5. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. (PMID: 11544257) Ajuh P. … Lamond A.I. (J. Biol. Chem. 2001) 3 23

Products for CDC5L Gene

Sources for CDC5L Gene

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