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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC5L Gene

protein-coding   GIFtS: 60
GCID: GC06P044402

cell division cycle 5-like

(Previous names: CDC5 (cell division cycle 5, S. pombe, homolog)-like, CDC5...)
 Explore 4 diseases affiliated with
CDC5L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDC5L    

Aliases
for CDC5L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle 5-Like1 2     CDC5-LIKE2
PCDC5RP1 2 3     CDC5 Cell Division Cycle 5-Like2
CDC51 2     Cdc5-Related Protein2
CEF11 2     Cell Division Cycle 5-Like Protein2
Pombe Cdc5-Related Protein2 3     DJ319D22.11
CDC5 (Cell Division Cycle 5, S. Pombe, Homolog)-Like1     DJ319D22.1 (CDC5-Like Protein)2
CDC5 Cell Division Cycle 5-Like (S. Pombe)1     KIAA04323
HCDC51     Cdc5-Like Protein3

External Ids:    HGNC: 17431   Entrez Gene: 9882   Ensembl: ENSG000000964017   OMIM: 6028685   UniProtKB: Q994593   

Export aliases for CDC5L gene to outside databases

Previous GC identifers: GC06P044357 GC06P044463 GC06P044078


Summaries
for CDC5L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDC5L:
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product,
which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive
regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome,
which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA
splicing. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459
Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the
PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing

Gene Wiki entry for CDC5L


Genomic Views
for CDC5L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC5L gene promoter:
         HFH-3   AML1a   Tal-1beta   HNF-1A   E47   FOXI1   AREB6   Hand1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC5L promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC5L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

CDC5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC5L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P044402:  view genomic region     (about GC identifiers)

Start:
 44,355,262 bp from pter      End:
 44,418,163 bp from pter
Size:
 62,902 bases      Orientation:
 plus strand

Proteins
for CDC5L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459 (See protein sequence)
Recommended Name: Cell division cycle 5-like protein  
Size: 802 amino acids; 92251 Da
Subunit: Homodimer. Interacts with DAPK3 (By similarity). Binds DNA. Binds to adeno-pre-mRNA in an ATP-stimulated
manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27,
CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C
complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19,
CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via
its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via
its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also
interacts with CTNNBL1
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus
Sequence caution: Sequence=BAA24862.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for CDC5L:
2DIM (3D)        2DIN (3D)    
Secondary accessions: Q76N46 Q99974

Explore the universe of human proteins at neXtProt for CDC5L: NX_Q99459

Post-translational modifications:

  • Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated
    • mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2.
    Phosphorylation enhances interaction with PPP1R81
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99459

    • CDC5L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001244.1  
    ENSEMBL proteins: 
     ENSP00000360532  

    Human Recombinant Protein Products: 
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    Novus Biologicals CDC5L Proteins
    Novus Biologicals CDC5L Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDC5L

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000974Prp19 complex IDA--
    GO:0005634nucleus NAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IDA16332694


    CDC5L for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDC5L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDC5L for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001005 SANT/Myb
     IPR017930 Myb_dom
     IPR021786 DUF3351
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99459

    ProtoNet protein and cluster: Q99459

    UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459
    Similarity: Belongs to the CEF1 family
    Similarity: Contains 2 HTH myb-type DNA-binding domains


    Function
    for CDC5L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459
    Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the
    PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing

         Genatlas biochemistry entry for CDC5L:
    protein,homolog to yeast CDC5-like-sequence,Myb-related,nuclear protein localizing in the nuclear speckles
    colocalizing,associating with core complements of the splicing machinery in nuclear extracts and interacting with the
    spliceoform,required for the pre-mRNA splicing,involved in the cell cycle essential for G2/M progression,disrupted in
    translocation t(6;19) (p21;q13.1) with multicystic renal dysplasia (see also PUJO) ubiquitously expressed in adult and
    fetal tissue

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CDC5L 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC5L (see all 7)
    OriGene shRNA RFP: CDC5L
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8917598
    GO:0003682chromatin binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding ----


    CDC5L for ontologies           About GeneDecksing


    11 GenomeRNAi human phenotypes for CDC5L:
     Decreased Hepatitis C virus re  Decreased viability  Decreased viability of wild-ty  Increased G2M DNA content, inc 
     Increased cell death HMECs cel  Increased cell death in breast  Increased cell number in G2M,   Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for CDC5L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CDC5L):
        Spliceosome


    CDC5L for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC5L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/892 Interacting proteins for CDC5L (Q994592, 3 ENSP000003605324) via UniProtKB, MINT, STRING, and/or I2D (see all 892)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPMP522722, 3, ENSP000003253764MINT-7979380 MINT-7947479 MINT-7979371 MINT-7979408 MINT-7979507 MINT-7945693 MINT-7979447 MINT-7979521 I2D: score=1 STRING: ENSP00000325376
    PRPF19Q9UMS42, 3, ENSP000002275244MINT-7945693 MINT-7262095 MINT-7947479 I2D: score=2 STRING: ENSP00000227524
    PLRG1O436602, 3, ENSP000003031914MINT-7979491 MINT-7945693 MINT-7947479 I2D: score=12 STRING: ENSP00000303191
    BCAS2O759342, 3, ENSP000003585544MINT-7945693 MINT-7947479 MINT-8336760 I2D: score=1 STRING: ENSP00000358554
    SNRPD3P623182, 3, ENSP000002158294MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000215829
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007049cell cycle IEA--


    CDC5L for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDC5L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC5L
    Search CenterWatch for drugs/clinical trials and news about CDC5L 

    Transcripts
    for CDC5L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDC5L gene: 
    NM_001253.3  

    Unigene Cluster for CDC5L:

    CDC5 cell division cycle 5-like (S. pombe)
    Hs.485471  [show with all ESTs]
    Unigene Representative Sequence: NM_001253
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371477(uc003oxl.3)

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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC5L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC5L

    Additional cDNA sequence: 

    AB007892.2 AK128737.1 AK299738.1 BC001568.1 D85423.1 U86753.1 

    11 DOTS entries:

    DT.100769379  DT.216850  DT.75149383  DT.121344629  DT.91919529  DT.95115992  DT.40229331  DT.100815803 
    DT.91771816  DT.97858958  DT.99944468 

    24/248 AceView cDNA sequences (see all 248):

    F09494 AA621872 BC001568 BU623810 NM_001253 CB044282 CB144032 AA749378 
    CR594844 AK128737 U86753 BM969643 AI983138 BU789615 AA576220 AL135197 
    BU687154 BP353743 AA604824 AI088288 BU073210 BM834441 AA305877 BQ961587 

    GeneLoc Exon Structure


    Expression
    for CDC5L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGATTCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CDC5L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC5L

    SOURCE GeneReport for Unigene cluster: Hs.485471

    UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459
    Tissue specificity: Ubiquitously expressed in both fetal and adult tissues

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    Orthologs
    for CDC5L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC5L gene from 9/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdc5l1 , 5 cell division cycle 5-like (S. pombe)1, 5 89.69(n)1
    98(a)1    		   17 (22.36 cM)5
    717021  NM_152810.21  NP_690023.11 
     453918925 
    chicken
    (Gallus gallus)    		 Aves CDC5L1 CDC5 cell division cycle 5-like (S. pombe) 80.9(n)
    91.89(a)    		   422052  XM_420058.3  XP_420058.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CDC5L6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 1(139402674-139446238)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU916302.12   -- 81.76(n)    BU916302.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC044511.12   -- 74.61(n)   394059  BC044511.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG69051 , 3 mRNA splicing pre-mRNA splicing factor3
    CG69051    		 62(a)3
    59.86(n)1
    65.98(a)1    		   61C13
    380621  NM_001169842.11  NP_001163313.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea D1081.81 Protein D1081.8 57.26(n)
    53.79(a)    		   172639  NM_059902.4  NP_492303.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CDC51 cell division cycle 5-like protein 54.59(n)
    48.64(a)    		   837506  NM_100849.2  NP_172448.1 
    rice
    (Oryza sativa)    		 Liliopsida AK102248.12   -- 74.46(n)    AK102248.1 


    ENSEMBL Gene Tree for CDC5L (if available)
    TreeFam Gene Tree for CDC5L (if available) 

    Paralogs
    for CDC5L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CDC5L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1118 NCBI SNPs in CDC5L are shown (see all 1118)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1393246331,2
    		--44353429(+) TGTTCC/TCAGAA 1 -- us2k10--------
    rs1489863341,2
    		--44353432(+) TCTCAA/GAACAC 1 -- us2k10--------
    rs94629841,2
    		C,F,--44353447(+) ATTTTA/GTGACA 1 -- us2k112Minor allele frequency- G:0.45NS NA WA CSA EA 511
    rs1908636971,2
    		--44353709(+) AAGGAC/GAGGAA 1 -- us2k10--------
    rs115718891,2
    		C,F,H,--44353837(+) GGTGTC/TACGTG 1 -- us2k1 tfbs315Minor allele frequency- T:0.04NS EA NA WA 2182
    rs115718901,2
    		C,F,--44353901(+) ATCTCG/AAAGAC 1 -- us2k12Minor allele frequency- A:0.04NS WA 292
    rs115718911,2
    		C,F,--44353952(+) TAATTT/CAATTG 1 -- us2k11Minor allele frequency- C:0.01NS 174
    rs1820430481,2
    		--44354112(+) TGTACC/TATGTA 1 -- us2k10--------
    rs1481158621,2
    		--44354151(+) AAAAAA/CACCGC 1 -- us2k10--------
    rs115718921,2
    		C,F,--44354188(+) AACATT/CTTGTT 1 -- us2k12Minor allele frequency- C:0.04NS WA 290

    HapMap Linkage Disequilibrium report for CDC5L (44355262 - 44418163 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CDC5L
         2 CNVs: 39448 51920

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    Disorders / Diseases
    for CDC5L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDC5L for disorders           About GeneDecksing

    OMIM gene information: 602868    OMIM disorders: --

    UniProtKB/Swiss-Prot: CDC5L_HUMAN, Q99459
  • Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation
    • t(6;19)(p21;q13.1) with USF2

    4 diseases for CDC5L:    About MalaCards
    cystoisosporiasis    osteosarcoma    schizophrenia    malaria

    1 disease from the University of Copenhagen DISEASES database for CDC5L:
    Cystoisosporiasis
    Human Genome Epidemiology (HuGE) Navigator: CDC5L (2 documents)

    Export disorders for CDC5L gene to outside databases

    Publications
    for CDC5L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC5L gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with CDC5L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. (PubMed id 9598309)1, 2, 3, 9 Groenen P.M.A....Van de Ven W.J.M. (1998)
    2. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. (PubMed id 9038199)1, 2, 3, 9 Bernstein H.S. and Coughlin S.R. (1997)
    3. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. (PubMed id 18583928)1, 2, 9 Graub R....Bernstein H.S. (2008)
    4. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. (PubMed id 11544257)1, 2, 9 Ajuh P.... Lamond A.I. (2001)
    5. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PubMed id 11101529)1, 2, 9 Ajuh P....Lamond A.I. (2000)
    6. A cdc5+ homolog of a higher plant, Arabidopsis thaliana. (PubMed id 8917598)1, 2, 9 Hirayama T. and Shinozaki K. (1996)
    7. CTNNBL1 is a novel nuclear localization sequence-bind ing protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K....Neuberger M. (2011)
    8. Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)1, 2 Grote M....LA1hrmann R. (2010)
    9. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. (PubMed id 18722174)1, 2 Conticello S.G....Neuberger M.S. (2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    External Searches for CDC5L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDC5L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 988 HGNC: 1743 AceView: CDC5L Ensembl:ENSG00000096401 euGenes: HUgn988
    ECgene: CDC5L Kegg: 988 H-InvDB: CDC5L

    Other Databases showing CDC5L gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0432

    Specialized Databases showing CDC5L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC5L Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc5l/

    Intellectual Property
    for CDC5L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDC5L gene:
    Search GeneIP for patents involving CDC5L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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