Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC5L Gene

Aliases for CDC5L Gene

  • Cell Division Cycle 5-Like 2 3
  • Pombe Cdc5-Related Protein 3 4
  • PCDC5RP 3 4
  • CDC5 (Cell Division Cycle 5, S. Pombe, Homolog)-Like 2
  • CDC5 Cell Division Cycle 5-Like (S. Pombe) 2
  • Cell Division Cycle 5-Like Protein 3
  • CDC5 Cell Division Cycle 5-Like 3
  • DJ319D22.1 (CDC5-Like Protein) 3
  • Cdc5-Related Protein 3
  • Cdc5-Like Protein 4
  • DJ319D22.1 3
  • CDC5-LIKE 3
  • KIAA0432 4
  • CDC5 3
  • CEF1 3

External Ids for CDC5L Gene

Previous GeneCards Identifiers for CDC5L Gene

  • GC06P044357
  • GC06P044402
  • GC06P044463
  • GC06P044078

Summaries for CDC5L Gene

Entrez Gene Summary for CDC5L Gene

  • The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC5L Gene

CDC5L (Cell Division Cycle 5-Like) is a Protein Coding gene. Diseases associated with CDC5L include cystoisosporiasis and poikiloderma with neutropenia. Among its related pathways are Spliceosome. GO annotations related to this gene include RNA binding and WD40-repeat domain binding.

UniProtKB/Swiss-Prot for CDC5L Gene

  • DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Wiki entry for CDC5L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC5L Gene

Genomics for CDC5L Gene

Regulatory Elements for CDC5L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC5L Gene

Start:
44,387,514 bp from pter
End:
44,450,426 bp from pter
Size:
62,913 bases
Orientation:
Plus strand

Genomic View for CDC5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC5L Gene

Proteins for CDC5L Gene

  • Protein details for CDC5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99459-CDC5L_HUMAN
    Recommended name:
    Cell division cycle 5-like protein
    Protein Accession:
    Q99459
    Secondary Accessions:
    • Q76N46
    • Q99974

    Protein attributes for CDC5L Gene

    Size:
    802 amino acids
    Molecular mass:
    92251 Da
    Quaternary structure:
    • Homodimer. Interacts with DAPK3 (By similarity). Belongs to the spliceosome complex. Part of a spliceosomal core complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts with CTNNBL1. Interacts with PRPF19 (via N-terminus) (By similarity).
    SequenceCaution:
    • Sequence=BAA24862.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC5L Gene

neXtProt entry for CDC5L Gene

Proteomics data for CDC5L Gene at MOPED

Post-translational modifications for CDC5L Gene

  • Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC5L Gene

Domains for CDC5L Gene

Protein Domains for CDC5L Gene

Suggested Antigen Peptide Sequences for CDC5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99459

UniProtKB/Swiss-Prot:

CDC5L_HUMAN :
  • Q99459
Domain:
  • Contains 2 HTH myb-type DNA-binding domains.
Family:
  • Belongs to the CEF1 family.
genes like me logo Genes that share domains with CDC5L: view

No data available for Gene Families for CDC5L Gene

Function for CDC5L Gene

Molecular function for CDC5L Gene

GENATLAS Biochemistry: protein,homolog to yeast CDC5-like-sequence,Myb-related,nuclear protein localizing in the nuclear speckles colocalizing,associating with core complements of the splicing machinery in nuclear extracts and interacting with the spliceoform,required for the pre-mRNA splicing,involved in the cell cycle essential for G2/M progression,disrupted in translocation t(6;19) (p21;q13.1) with multicystic renal dysplasia (see also PUJO) ubiquitously expressed in adult and fetal tissue
UniProtKB/Swiss-Prot Function: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Ontology (GO) - Molecular Function for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8917598
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 15232106
GO:0019904 protein domain specific binding --
genes like me logo Genes that share ontologies with CDC5L: view
genes like me logo Genes that share phenotypes with CDC5L: view

Animal Model Products

CRISPR Products

Transcription Factor Targeting for CDC5L Gene

Selected GeneGlobe predicted Target genes for CDC5L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC5L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for CDC5L Gene

Localization for CDC5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC5L Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269 PubMed:9038199}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC5L Gene COMPARTMENTS Subcellular localization image for CDC5L gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IDA 20176811
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005662 colocalizes_with DNA replication factor A complex IDA 24332808
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CDC5L: view

Pathways for CDC5L Gene

SuperPathways for CDC5L Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with CDC5L: view

Pathways by source for CDC5L Gene

1 KEGG pathway for CDC5L Gene

Gene Ontology (GO) - Biological Process for CDC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with CDC5L: view

Transcripts for CDC5L Gene

mRNA/cDNA for CDC5L Gene

Unigene Clusters for CDC5L Gene

Cell division cycle 5-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC5L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC5L Gene

No ASD Table

Relevant External Links for CDC5L Gene

GeneLoc Exon Structure for
CDC5L
ECgene alternative splicing isoforms for
CDC5L

Expression for CDC5L Gene

mRNA expression in normal human tissues for CDC5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC5L Gene

SOURCE GeneReport for Unigene cluster for CDC5L Gene Hs.485471

mRNA Expression by UniProt/SwissProt for CDC5L Gene

Q99459-CDC5L_HUMAN
Tissue specificity: Ubiquitously expressed in both fetal and adult tissues.
genes like me logo Genes that share expressions with CDC5L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDC5L Gene

Orthologs for CDC5L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC5L 35
  • 96.63 (n)
  • 96.01 (a)
CDC5L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC5L 35
  • 93.81 (n)
  • 98.88 (a)
CDC5L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC5L 35
  • 94.18 (n)
  • 99 (a)
CDC5L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc5l 35
  • 89.69 (n)
  • 98 (a)
Cdc5l 16
Cdc5l 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDC5L 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc5l 35
  • 89.65 (n)
  • 97.88 (a)
chicken
(Gallus gallus)
Aves CDC5L 35
  • 80.9 (n)
  • 91.89 (a)
CDC5L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC5L 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc5l 35
  • 75.87 (n)
  • 86.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7318 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cdc5l 35
  • 71.37 (n)
  • 84.25 (a)
cdc5l 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002954 35
  • 58.05 (n)
  • 66.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6905 35
  • 60.08 (n)
  • 66.11 (a)
CG6905 36
  • 63 (a)
OneToOne
CG6905 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea D1081.8 35
  • 57.38 (n)
  • 54.29 (a)
D1081.8 36
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEF1 36
  • 34 (a)
OneToOne
CEF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC5 35
  • 54.64 (n)
  • 48.64 (a)
corn
(Zea mays)
Liliopsida Zm.9391 35
rice
(Oryza sativa)
Liliopsida Os04g0348300 35
  • 55.78 (n)
  • 52.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06994 35
  • 51.55 (n)
  • 48.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc5 35
  • 53.41 (n)
  • 47.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9863 36
  • 63 (a)
OneToOne
Species with no ortholog for CDC5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC5L Gene

ENSEMBL:
Gene Tree for CDC5L (if available)
TreeFam:
Gene Tree for CDC5L (if available)

Paralogs for CDC5L Gene

No data available for Paralogs for CDC5L Gene

Variants for CDC5L Gene

Sequence variations from dbSNP and Humsavar for CDC5L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs475426 -- 44,441,241(+) atatg(A/G)tattt intron-variant
rs483384 -- 44,450,864(+) GTAGT(C/T)TTGTT downstream-variant-500B
rs487711 -- 44,430,146(+) AGAGT(C/G)CCCTG intron-variant
rs490814 -- 44,436,918(+) AAATT(C/G)CTATC intron-variant
rs518982 -- 44,450,060(+) GGTTT(C/T)GCTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDC5L Gene

Variant ID Type Subtype PubMed ID
esv1198309 CNV Deletion 17803354
nsv885858 CNV Gain+Loss 21882294
nsv885859 CNV Loss 21882294
nsv517370 CNV Gain+Loss 19592680

Relevant External Links for CDC5L Gene

HapMap Linkage Disequilibrium report
CDC5L
Human Gene Mutation Database (HGMD)
CDC5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC5L Gene

Disorders for CDC5L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CDC5L Gene including...

Search for CDC5L Gene in MalaCards »

UniProtKB/Swiss-Prot

CDC5L_HUMAN
  • Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.

(1) University of Copenhagen DISEASES for CDC5L Gene

Relevant External Links for CDC5L

Genetic Association Database (GAD)
CDC5L
Human Genome Epidemiology (HuGE) Navigator
CDC5L
genes like me logo Genes that share disorders with CDC5L: view

Publications for CDC5L Gene

  1. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. (PMID: 9038199) Bernstein H.S. … Coughlin S.R. (J. Biol. Chem. 1997) 2 3 4 23
  2. Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. (PMID: 9598309) Groenen P.M.A. … Van de Ven W.J.M. (Genomics 1998) 2 3 4 23
  3. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PMID: 11101529) Ajuh P. … Lamond A.I. (EMBO J. 2000) 3 4 23
  4. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. (PMID: 11544257) Ajuh P. … Lamond A.I. (J. Biol. Chem. 2001) 3 4 23
  5. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. (PMID: 18583928) Graub R. … Bernstein H.S. (Cell Cycle 2008) 3 4 23

Products for CDC5L Gene

Sources for CDC5L Gene

Back to Top

Content