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CDC45 Gene

protein-coding   GIFtS: 62
GCID: GC22P019466

Cell Division Cycle 45

(Previous names: CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like,...)
(Previous symbols: CDC45L2, CDC45L)
  See CDC45-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 451 2     Cell Division Cycle 45 Homolog (S. Cerevisiae)1
CDC45L1 2 3 5     CDC45 Cell Division Cycle 45 Homolog2
CDC45L21 2 3 5     CDC45-Related Protein2
Human CDC451 2     Cell Division Control Protein 45 Homolog2
PORC-PI-12 3     Cell Division Cycle 45 Homolog2
CDC45 (Cell Division Cycle 45, S.Cerevisiae, Homolog)-Like1     Cell Division Cycle 45-Like 22
CDC45 Cell Division Cycle 45-Like (S. Cerevisiae)1     

External Ids:    HGNC: 17391   Entrez Gene: 83182   Ensembl: ENSG000000930097   OMIM: 6034655   UniProtKB: O754193   

Export aliases for CDC45 gene to outside databases

Previous GC identifer: GC22P003088


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC45 Gene:
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an
essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved
multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase,
which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with
MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal
role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for CDC45 Gene:
CDC45 (cell division cycle 45) is a protein-coding gene. Diseases associated with CDC45 include rothmund-thomson syndrome.

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419
Function: Required for initiation of chromosomal DNA replication

Gene Wiki entry for CDC45 (CDC45-related protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDC45
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC45 promoter sequence
   Search Chromatin IP Primers for CDC45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

CDC45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC45 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P019466:  view genomic region     (about GC identifiers)

Start:
19,466,982 bp from pter      End:
19,508,135 bp from pter
Size:
41,154 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419 (See protein sequence)
Recommended Name: Cell division control protein 45 homolog  
Size: 566 amino acids; 65569 Da
Subunit: Associated with ORC2
Developmental stage: Transcript peaks at G1-S transition, but total protein remains constant throughout the cell
cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures
Secondary accessions: B4DDB4 B4DDU3 E9PDH7 O60856 Q20WK8 Q6UW54 Q9UP68
Alternative splicing: 3 isoforms:  O75419-1   O75419-2   O75419-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC45: NX_O75419

Explore proteomics data for CDC45 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys237, Lys337, Lys350, Lys411, Lys528
  • Modification sites at PhosphoSitePlus

  • See CDC45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171481.1  NP_001171482.1  NP_003495.1  

    ENSEMBL proteins: 
     ENSP00000385240   ENSP00000397434   ENSP00000413138   ENSP00000384978   ENSP00000388280  
     ENSP00000405726   ENSP00000263201  
    Reactome Protein details: O75419

    CDC45 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDC45

     
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    CDC45 Antibody Products:

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    Search eBioscience for ELISAs for CDC45 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003874 CDC45

    Graphical View of Domain Structure for InterPro Entry O75419

    ProtoNet protein and cluster: O75419

    1 Blocks protein domain: IPB003874 CDC45-like protein

    UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419
    Similarity: Belongs to the CDC45 family


    Find genes that share domains with CDC45           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC45_HUMAN, O75419
    Function: Required for initiation of chromosomal DNA replication

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10518787
         
    Find genes that share ontologies with CDC45           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDC45:
     Decreased Wnt reporter activit  Increased S DNA content  Increased cell death in HCT116  Increased gamma-H2AX phosphory 
     S arrest  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdc45):
     cellular  embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with CDC45           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdc45tm1Dta for CDC45

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC45
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC45
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC45

    miRNA
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    miRTarBase miRNAs that target CDC45:
    hsa-mir-455-3p (MIRT037897)

    Block miRNA regulation of human, mouse, rat CDC45 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDC45
    SwitchGear 3'UTR luciferase reporter plasmidCDC45 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC45


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC45_HUMAN, O75419: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    extracellular2
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with CDC45           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC45 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    G1 to S cell cycle control0.35
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.92
    DNA Replication Pre-Initiation0.81
    DNA Replication0.92
    S Phase0.78
    M/G1 Transition0.81
    Cell Cycle Checkpoints0.58
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CDC45           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDC45
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for CDC45
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDC45
        Cell cycle Start of DNA replication in early S phase

    4 BioSystems Pathways for CDC45
        Cell cycle
    G1 to S cell cycle control
    DNA Replication
    RB in Cancer

    5 Reactome Pathways for CDC45
        Unwinding of DNA
    Activation of ATR in response to replication stress
    Activation of the pre-replicative complex
    E2F mediated regulation of DNA replication
    G1/S-Specific Transcription


    1 Kegg Pathway  (Kegg details for CDC45):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC45
    Interactions:

        Search GeneGlobe Interaction Network for CDC45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC45 (O754191, 2, 3 ENSP000002632014) via UniProtKB, MINT, STRING, and/or I2D (see all 253)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint TAS9660782
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--

    Find genes that share ontologies with CDC45           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC45

    1 Novoseek inferred chemical compound relationship for CDC45 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 36.7 2 12185086 (1), 16479016 (1)



    Find genes that share compounds with CDC45           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC45 gene (3 alternative transcripts): 
    NM_001178010.2  NM_001178011.2  NM_003504.4  

    Unigene Cluster for CDC45:

    Cell division cycle 45
    Hs.474217  [show with all ESTs]
    Unigene Representative Sequence: NM_001178010
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407835(uc002zpr.3 uc002zpt.3) ENST00000438587 ENST00000455750
    ENST00000491520 ENST00000483431 ENST00000404724 ENST00000487669 ENST00000428937
    ENST00000471470 ENST00000493724 ENST00000437685(uc021wlg.1 uc011agz.1 uc011aha.2)
    ENST00000263201
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC45
      QuantiTect SYBR Green Assays in human, mouse, rat CDC45
      QuantiFast Probe-based Assays in human, mouse, rat CDC45

    Additional mRNA sequence: 

    AF053074.1 AF062495.1 AF081535.1 AJ223728.1 AK293123.1 AK293338.1 AY358971.1 BC006232.2 
    BC010022.2 BT006792.1 CT841513.1 

    15 DOTS entries:

    DT.412531  DT.100836839  DT.101963610  DT.100724347  DT.100836842  DT.95368777  DT.120652442  DT.100045664 
    DT.100836840  DT.100024118  DT.100024119  DT.100733499  DT.120652598  DT.120652519  DT.92428256 

    Selected AceView cDNA sequences (see all 150):

    BF509824 AI953232 T34235 AI369688 NM_003504 AI220589 AA356690 BX422691 
    AW674262 AF081535 BC006232 BX346464 BC010022 BQ427880 AA355389 BT006792 
    AL711006 BM751026 CR591338 BQ436443 CR594150 CR619108 AF053074 BU171037 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDC45    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                  -                                                         
    SP2:                                -     -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CDC45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGAGATG
    CDC45 Expression
    About this image


    CDC45 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    CDC45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474217

    UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419
    Tissue specificity: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC45 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc451 , 5 cell division cycle 45 homolog (S. cerevisiae)5
    cell division cycle 451
    88.1(n)1
    91.7(a)1
      16 (11.63 cM)5
    125441  NM_009862.21  NP_033992.21 
     187804475 
    chicken
    (Gallus gallus)
    Aves CDC451 cell division cycle 45 homolog (S. cerevisiae) 76.74(n)
    83.22(a)
      416776  XM_415070.4  XP_415070.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDC456
    cell division cycle 45
    81(a)
    1 ↔ 1
    GL343282.1(1495441-1512260)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980812 Cdc45 77.43(n)    AF062494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi05h012 Danio rerio cDNA clone MGC56264 IMAGE5601994, complete more 76.51(n)    BC050511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CDC45L1 CDC45L 50.54(n)
    41.58(a)
      31052  NM_130524.4  NP_569880.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F34D10.21 F34D10.2 42.95(n)
    31.43(a)
      175481  NM_065355.4  NP_497756.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC45(YLR103C)4
    CDC451
    DNA replication initiation factor; recruited to MCM more4
    CDC451
    41.7(n)1
    30.07(a)1
      12(345941-343989)4
    8507931, 4  NP_013204.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDC451 CDC45 43.8(n)
    32.71(a)
      822101  NM_113414.2  NP_189146.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01284001 Os11g0128400 45.53(n)
    32.83(a)
      4349656  NM_001072167.1  NP_001065635.1 


    ENSEMBL Gene Tree for CDC45 (if available)
    TreeFam Gene Tree for CDC45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC45 (see all 913)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680838441,2
    C--3094389(-) TGACA-/GAGT  
            
    GAGAC
    3 -- int12Minor allele frequency- GAGT:0.25NA 4
    rs717863601,2
    C--3101794(+) TTTTT-/TTGTT 
            
    GTTGT
    3 -- int10--------
    rs1809763741,2
    --19468755(+) TTGACA/CGCAAA 3 -- int10--------
    rs1861536281,2
    --19468827(+) TTGATC/TGTAAG 3 -- int10--------
    rs1918726181,2
    --19468864(+) ATGGTC/TTAGTT 3 -- int10--------
    rs1840643561,2
    --19468961(+) CAGTGG/TCACGA 3 -- int10--------
    rs134471931,2
    C,F--19468984(+) gcaagC/Ttgtgt 3 -- int11Minor allele frequency- T:0.01NS 166
    rs1503563691,2
    --19469092(+) AGAGAC/TGGAGT 3 -- int10--------
    rs134471941,2
    C,F--19469187(+) caccaC/Tgccca 3 -- int11Minor allele frequency- T:0.02NS 170
    rs1859351561,2
    --19469217(+) TGAGAC/TGGAAC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CDC45 (19466982 - 19508135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDC45:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435744CNV Deletion17901297
    nsv3558CNV Insertion18451855
    nsv834127CNV Loss17160897
    dgv4840n71CNV Loss21882294
    nsv914263CNV Gain21882294
    esv2751940CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC45
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603465    OMIM disorders: --

    1 disease for CDC45:    
    About MalaCards
    rothmund-thomson syndrome

    2 diseases from the University of Copenhagen DISEASES database for CDC45:
    DiGeorge syndrome     Rothmund-Thomson syndrome

    Find genes that share disorders with CDC45           About GenesLikeMe

    1 Novoseek inferred disease relationship for CDC45 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    digeorge syndrome 68.1 2 9660782 (1), 11416137 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDC45 (3 documents)

    Export disorders for CDC45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC45 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with CDC45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of Saccharomyces cerevisiae CDC45. (PubMed id 9660782)1, 2, 3, 9 Saha P.... Dutta A. (J. Biol. Chem. 1998)
    2. Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. (PubMed id 9724329)1, 2, 3, 9 McKie J.M.... Scambler P.J. (Genome Res. 1998)
    3. Human Cdc45 is a proliferation-associated antigen. (PubMed id 17608804)1, 3, 9 Pollok S....Grosse F. (FEBS J. 2007)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. (PubMed id 10051334)1, 2 Shaikh T.H.... Budarf M.L. (Mamm. Genome 1999)
    8. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. (PubMed id 20065034)1, 9 Chowdhury A....Leffak M. (Mol. Cell. Biol. 2010)
    9. Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. (PubMed id 17887956)1, 9 Schmidt U....HAonel F. (Biochem. J. 2008)
    10. Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation. (PubMed id 15753125)1, 9 Alexandrow M.G. and Hamlin J.L. (J. Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8318 HGNC: 1739 AceView: CDC45L Ensembl:ENSG00000093009 euGenes: HUgn8318
    ECgene: CDC45 Kegg: 8318 H-InvDB: CDC45

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC45 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc45l/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC45 gene:
    Search GeneIP for patents involving CDC45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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