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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC45 Gene

protein-coding GIFtS: 61
GCID: GC22P019466

cell division cycle 45

(Previous names: CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like,...)
(Previous symbols: CDC45L2, CDC45L)

Explore 7 diseases affiliated with
CDC45 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 45¹ ²		CDC45 Cell Division Cycle 45 Homolog²
CDC45L¹ ² ³ ⁵		CDC45-Related Protein²
CDC45L2¹ ² ³ ⁵		Cell Division Control Protein 45 Homolog²
PORC-PI-1² ³		Cell Division Cycle 45 Homolog²
CDC45 (Cell Division Cycle 45, S.Cerevisiae, Homolog)-Like¹		Cell Division Cycle 45-Like 2²
CDC45 Cell Division Cycle 45-Like (S. Cerevisiae)¹		Human CDC45²
Cell Division Cycle 45 Homolog (S. Cerevisiae)¹

External Ids:	HGNC: 1739¹	Entrez Gene: 8318²	Ensembl: ENSG00000093009⁷	OMIM: 603465⁵	UniProtKB: O75419³

Export aliases for CDC45 gene to outside databases

Previous GC identifer: GC22P003088

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC45:

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an

essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved

multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is

important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA

polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the

loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419

Function: Required for initiation of chromosomal DNA replication

Gene Wiki entry for CDC45 (CDC45-related protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011519.10

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CDC45
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC45 promoter sequence

Search SABiosciences Chromatin IP Primers for CDC45

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC45

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

CDC45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC45 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P019466: view genomic region (about GC identifiers)

Start:	19,466,982 bp from pter	End:	19,508,135 bp from pter
Size:	41,154 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419 (See protein sequence)

Recommended Name: Cell division control protein 45 homolog

Size: 566 amino acids; 65569 Da

Subunit: Associated with ORC2

Subcellular location: Cytoplasm. Nucleus

Developmental stage: Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle.

Expressed in multiple tissues during embryogenesis, including neural crest-derived structures

Secondary accessions: B4DDB4 B4DDU3 E9PDH7 O60856 Q20WK8 Q6UW54 Q9UP68

Alternative splicing: 3 isoforms: O75419-1 O75419-2 O75419-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC45: NX_O75419

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75419

CDC45 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_003495.1 NP_001171481.1 NP_001171482.1

ENSEMBL proteins:

ENSP00000385240 ENSP00000397434 ENSP00000413138 ENSP00000384978 ENSP00000388280

ENSP00000405726 ENSP00000263201

Reactome Protein details: O75419
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CDC45 OriGene Protein Over-expression Lysate: CDC45 OriGene Custom Protein Services for CDC45
	GenScript Custom Purified and Recombinant Proteins Services for CDC45
	Novus Biologicals CDC45 Proteins Novus Biologicals CDC45 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC45

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	--

CDC45 for ontologies About GeneDecksing

CDC45 Antibody Products:

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	GenScript Custom Assay Services for CDC45
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC45

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC45 for domains About GeneDecksing

1 InterPro domain/family:

IPR003874 CDC45

Graphical View of Domain Structure for InterPro Entry O75419

ProtoNet protein and cluster: O75419

1 Blocks protein family: IPB003874 CDC45-like protein

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419

Similarity: Belongs to the CDC45 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419

Function: Required for initiation of chromosomal DNA replication

miRNA Products:		OriGene 3'-UTR Clone: CDC45 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC45
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC45 (see all 4) OriGene shRNA RFP: CDC45 OriGene siRNA: CDC45
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for CDC45

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): CDC45 (NM_003504)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC45
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC45

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC45
		Search LifeMap BioReagents cell lines for CDC45

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC45

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17887956

CDC45 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for CDC45:

Decreased Wnt reporter activit	Increased S DNA content	Increased cell death in HCT116	Increased gamma-H2AX phosphory
S arrest	Synthetic lethal with Ras

Animal Models:
Mouse knock-out Cdc45^tm1Dta for CDC45
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdc45):

cellular

embryogenesis

mortality/aging

normal

CDC45 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

DNA Replication Pre-Initiation	0.62	DNA Replication	0.49
M/G1 Transition	0.62	Cell Cycle Checkpoints	0.42
Synthesis of DNA	0.51	S Phase	0.40

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CDC45

Cell cycle Start of DNA replication in early S phase

1 Cell Signaling Technology (CST) Pathway for CDC45

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for CDC45

Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for CDC45

	G1 to S cell cycle control
	Cell cycle
	DNA Replication

5/19 Reactome Pathways for CDC45 (see all 19)

	Unwinding of DNA
	Synthesis of DNA
	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication

1 Kegg Pathway (Kegg details for CDC45):

Cell cycle

CDC45 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDC45

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/137 Interacting proteins for CDC45 (O75419^{1, 2, 3} ENSP00000263201⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 137)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000076	DNA replication checkpoint	TAS	9660782
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--

CDC45 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC45 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC45
1 Novoseek chemical compound relationship for CDC45 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
okadaic acid	36.7	2	12185086 (1), 16479016 (1)

Search CenterWatch for drugs/clinical trials and news about CDC45

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC45 gene (3 alternative transcripts):

NM_003504.3 NM_001178010.1 NM_001178011.1

Unigene Cluster for CDC45:

Cell division cycle 45 homolog (S. cerevisiae)

Hs.474217 [show with all ESTs]

Unigene Representative Sequence: NM_001178010

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000407835(uc002zpr.3 uc002zpt.3) ENST00000438587 ENST00000455750

ENST00000491520 ENST00000483431 ENST00000404724 ENST00000487669 ENST00000428937

ENST00000471470 ENST00000493724 ENST00000437685(uc021wlg.1 uc011agz.1 uc011aha.2)

ENST00000263201

miRNA Products:		OriGene 3'-UTR Clone: CDC45 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC45
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC45 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC45 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CDC45 (NM_003504)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC45 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC45
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC45
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC45

Additional cDNA sequence:

AF053074.1 AF062495.1 AF081535.1 AJ223728.1 AK293123.1 AK293338.1 AY358971.1 BC006232.2

BC010022.2 BT006792.1 CT841513.1

15 DOTS entries:

DT.412531 DT.100836839 DT.101963610 DT.100724347 DT.100836842 DT.95368777 DT.120652442 DT.100045664

DT.100836840 DT.100024118 DT.100024119 DT.100733499 DT.120652598 DT.120652519 DT.92428256

24/150 AceView cDNA sequences (see all 150):

CR608720 BF509824 BC006232 AA355389 BX117447 AF081535 BM557094 AI220589

AW674262 NM_003504 AF053074 AA356690 CR604288 BX328421 BX352910 BM478173

CR603724 BE795241 BQ427880 BX346464 AL711006 BU171037 BX422691 AI369688

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CDC45 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:																																	-
SP2:											-		-
SP3:
SP4:
SP5:

ExUns:	20
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CDC45

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTGAGATG

About this image

CDC45 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See CDC45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC45

SOURCE GeneReport for Unigene cluster: Hs.474217

UniProtKB/Swiss-Prot: CDC45_HUMAN, O75419

Tissue specificity: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver

SABiosciences Custom PCR Arrays for CDC45

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC45 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC45

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC45

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC45 gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdc45^{1 , 5}	cell division cycle 45 homolog (S. cerevisiae)⁵ cell division cycle 45¹	88.1(n)¹ 91.7(a)¹		16 (11.63 cM)⁵ 12544¹ NM_009862.2¹ NP_033992.2¹ 18780447⁵
chicken (Gallus gallus)	Aves	CDC45¹	cell division cycle 45 homolog (S. cerevisiae)	76.74(n) 83.22(a)		416776 XM_415070.3 XP_415070.2
lizard (Anolis carolinensis)	Reptilia	CDC45⁶	--	81(a)	1 ↔ 1	GL343282.1(1496263-1511942)
African clawed frog (Xenopus laevis)	Amphibia	LOC398081²	Cdc45	77.43(n)		AF062494.1
zebrafish (Danio rerio)	Actinopterygii	wufi05h01²	Danio rerio cDNA clone MGC56264 IMAGE5601994, complete more	76.51(n)		BC050511.1
fruit fly (Drosophila melanogaster)	Insecta	CDC45L¹	CDC45L	50.18(n) 41.22(a)		31052 NM_130524.4 NP_569880.1
worm (Caenorhabditis elegans)	Secernentea	F34D10.2¹	Protein F34D10.2	42.27(n) 30.29(a)		175481 NM_065355.3 NP_497756.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC45(YLR103C)⁴ CDC45¹	DNA replication initiation factor; recruited to MCM more⁴ Cdc45p¹	42.05(n)¹ 30.07(a)¹		12(345941-343989)⁴ 850793^{1, 4} NP_013204.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CDC45¹	cell division control protein 45	42.8(n) 31.43(a)		822101 NM_113414.2 NP_189146.1
rice (Oryza sativa)	Liliopsida	Os12g0124700¹	hypothetical protein	45.09(n) 32.84(a)		4351377 NM_001072573.1 NP_001066041.1

ENSEMBL Gene Tree for CDC45 (if available)
TreeFam Gene Tree for CDC45 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180976374^1,2		--	19468755(+)	`TTGACA/CGCAAA`	3	--	int¹		0	--	--	--	--
rs186153628^1,2		--	19468827(+)	`TTGATC/TGTAAG`	3	--	int¹		0	--	--	--	--
rs191872618^1,2		--	19468864(+)	`ATGGTC/TTAGTT`	3	--	int¹		0	--	--	--	--
rs184064356^1,2		--	19468961(+)	`CAGTGG/TCACGA`	3	--	int¹		0	--	--	--	--
rs13447193^1,2	C,F,	--	19468984(+)	`gcaagC/Ttgtgt`	3	--	int¹		1		NS	166
rs150356369^1,2		--	19469092(+)	`AGAGAC/TGGAGT`	3	--	int¹		0	--	--	--	--
rs13447194^1,2	C,F,	--	19469187(+)	`caccaC/Tgccca`	3	--	int¹		1		NS	170
rs185935156^1,2		--	19469217(+)	`TGAGAC/TGGAAC`	3	--	int¹		0	--	--	--	--
rs111610851^1,2	C,	--	19469225(+)	`AACCTC/TGCTTT`	3	--	int¹		1		WA	2
rs8136117^1,2	C,F,A,	--	19469322(+)	`CCTAAC/ATAGCT`	3	--	int¹		3		NA NS WA	182

HapMap Linkage Disequilibrium report for CDC45 (19466982 - 19508135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC45: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC45 for disorders           About GeneDecksing

OMIM gene information: 603465    OMIM disorders: --

7 diseases for CDC45:    About MalaCards

rothmund-thomson syndrome digeorge syndrome seckel syndrome velocardiofacial syndrome

chronic lymphocytic leukemia lymphocytic leukemia leukemia

2 diseases from the University of Copenhagen DISEASES database for CDC45:

DiGeorge syndrome Rothmund-Thomson syndrome

1 Novoseek disease relationship for CDC45 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
digeorge syndrome	68.1	2	9660782 (1), 11416137 (1)

Human Genome Epidemiology (HuGE) Navigator: CDC45 (3 documents)

Export disorders for CDC45 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC45 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with CDC45)

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world of online information

The human homolog of Saccharomyces cerevisiae CDC45. (PubMed id 9660782)^{1, 2, 3, 9} Saha P.... Dutta A. (1998)
Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. (PubMed id 9724329)^{1, 2, 3, 9} McKie J.M.... Scambler P.J. (1998)
Human Cdc45 is a proliferation-associated antigen. (PubMed id 17608804)^{1, 3, 9} Pollok S....Grosse F. (2007)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. (PubMed id 10051334)^{1, 2} Shaikh T.H.... Budarf M.L. (1999)
The DNA unwinding element binding protein DUE-B inter acts with Cdc45 in preinitiation complex formation. (PubMed id 20065034)^{1, 9} Chowdhury A....Leffak M. (2010)
Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. (PubMed id 17887956)^{1, 9} Schmidt U....Hanel F. (2008)
Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation. (PubMed id 15753125)^{1, 9} Alexandrow M.G. and Hamlin J.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8318	HGNC: 1739	AceView: CDC45L	Ensembl:ENSG00000093009	euGenes: HUgn8318
ECgene: CDC45	Kegg: 8318	H-InvDB: CDC45

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC45	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc45l/

Intellectual Property for CDC45 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDC45 gene:
Search GeneIP for patents involving CDC45

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cell division cycle 45

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cell division cycle 45

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