Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC45 Gene

Aliases for CDC45 Gene

  • Cell Division Cycle 45 2 3 5
  • Human CDC45 2 3
  • PORC-PI-1 3 4
  • CDC45L2 3 4
  • CDC45L 3 4
  • CDC45 (Cell Division Cycle 45, S.Cerevisiae, Homolog)-Like 2
  • CDC45 Cell Division Cycle 45-Like (S. Cerevisiae) 2
  • Cell Division Cycle 45 Homolog (S. Cerevisiae) 2
  • Cell Division Control Protein 45 Homolog 3
  • CDC45 Cell Division Cycle 45 Homolog 3
  • CDC45 Cell Division Cycle 45-Like 3
  • Cell Division Cycle 45 Homolog 3
  • Cell Division Cycle 45-Like 2 3
  • CDC45-Related Protein 3
  • MGORS7 3

External Ids for CDC45 Gene

Previous HGNC Symbols for CDC45 Gene

  • CDC45L2
  • CDC45L

Previous GeneCards Identifiers for CDC45 Gene

  • GC22P003088

Summaries for CDC45 Gene

Entrez Gene Summary for CDC45 Gene

  • The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CDC45 Gene

CDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include Meier-Gorlin Syndrome 7 and Meier-Gorlin Syndrome 1. Among its related pathways are DNA Damage and E2F mediated regulation of DNA replication. GO annotations related to this gene include chromatin binding and DNA replication origin binding.

UniProtKB/Swiss-Prot for CDC45 Gene

  • Required for initiation of chromosomal DNA replication.

Gene Wiki entry for CDC45 Gene

Additional gene information for CDC45 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC45 Gene

Genomics for CDC45 Gene

Regulatory Elements for CDC45 Gene

Enhancers for CDC45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H019576 1.4 FANTOM5 Ensembl ENCODE 10.8 +97.7 97662 1.7 HDAC1 HDGF ATF1 KLF17 ZNF766 GLIS2 EGR1 FOS ATF7 CREM CLDN5 UFD1 CDC45 CLTCL1 LINC00895 GC22P019632
GH22H019607 1.3 Ensembl ENCODE dbSUPER 11.5 +128.3 128311 1.1 FOXA2 KLF1 TAF1 KLF17 MAX BMI1 RAD21 YY1 GATA2 HNF4G CLDN5 CDC45 UFD1 GC22P019632 LINC00895
GH22H019579 1.3 FANTOM5 Ensembl ENCODE 10.6 +100.4 100438 1.6 JUN MAX IKZF2 L3MBTL2 CAVIN1 BHLHE40 USF2 ZNF354B HDAC8 GTF2A2 DGCR8 TRMT2A CLDN5 MED15 DGCR11 CDC45 UFD1 RANBP1 LINC01311 LOC100420177
GH22H019629 1 ENCODE 12.1 +150.7 150708 0.2 HDGF PKNOX1 ATF1 ARNT ARID4B ZNF2 ZNF143 ZNF207 ATF7 RUNX3 TRMT2A DGCR8 CLDN5 CDC45 UFD1 MED15 DGCR11 RANBP1 ESS2 GC22P019632
GH22H019632 0.9 ENCODE 12.3 +153.0 152968 0.2 HDAC1 HDGF RB1 TBL1XR1 ARNT BMI1 RAD21 CBX5 CREM HCFC1 CDC45 UFD1 SEPT5 GP1BB GC22P019632 LINC00895
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC45 on UCSC Golden Path with GeneCards custom track

Promoters for CDC45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CDC45 Gene

Genomic Locations for CDC45 Gene
41,228 bases
Plus strand

Genomic View for CDC45 Gene

Genes around CDC45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC45 Gene

Proteins for CDC45 Gene

  • Protein details for CDC45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell division control protein 45 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DDB4
    • B4DDU3
    • E9PDH7
    • O60856
    • Q20WK8
    • Q6UW54
    • Q9UP68

    Protein attributes for CDC45 Gene

    566 amino acids
    Molecular mass:
    65569 Da
    Quaternary structure:
    • Associated with ORC2. Interacts with HELB (PubMed:25933514).

    Three dimensional structures from OCA and Proteopedia for CDC45 Gene

    Alternative splice isoforms for CDC45 Gene


neXtProt entry for CDC45 Gene

Post-translational modifications for CDC45 Gene

  • Ubiquitination at Lys8, Lys237, Lys337, posLast=350350, Lys411, and Lys528
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC45 Gene

Domains & Families for CDC45 Gene

Gene Families for CDC45 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CDC45 Gene


Suggested Antigen Peptide Sequences for CDC45 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDC45 family.
  • Belongs to the CDC45 family.
genes like me logo Genes that share domains with CDC45: view

Function for CDC45 Gene

Molecular function for CDC45 Gene

UniProtKB/Swiss-Prot Function:
Required for initiation of chromosomal DNA replication.

Phenotypes From GWAS Catalog for CDC45 Gene

Gene Ontology (GO) - Molecular Function for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0003688 DNA replication origin binding IBA --
GO:0003697 single-stranded DNA binding IBA --
GO:0005515 protein binding IPI 10518787
GO:0043138 3-5 DNA helicase activity IBA --
genes like me logo Genes that share ontologies with CDC45: view
genes like me logo Genes that share phenotypes with CDC45: view

Animal Models for CDC45 Gene

MGI Knock Outs for CDC45:

miRNA for CDC45 Gene

miRTarBase miRNAs that target CDC45

Clone Products

  • Addgene plasmids for CDC45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC45 Gene

Localization for CDC45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC45 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC45 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 21383955
GO:0005654 nucleoplasm TAS --
GO:0005656 nuclear pre-replicative complex IBA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CDC45: view

Pathways & Interactions for CDC45 Gene

genes like me logo Genes that share pathways with CDC45: view

Pathways by source for CDC45 Gene

1 KEGG pathway for CDC45 Gene
1 GeneGo (Thomson Reuters) pathway for CDC45 Gene
1 Qiagen pathway for CDC45 Gene

Gene Ontology (GO) - Biological Process for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint TAS 9660782
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0006260 DNA replication TAS --
genes like me logo Genes that share ontologies with CDC45: view

No data available for SIGNOR curated interactions for CDC45 Gene

Drugs & Compounds for CDC45 Gene

(1) Drugs for CDC45 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDC45: view

Transcripts for CDC45 Gene

Unigene Clusters for CDC45 Gene

Cell division cycle 45:
Representative Sequences:

Clone Products

  • Addgene plasmids for CDC45

Alternative Splicing Database (ASD) splice patterns (SP) for CDC45 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - -

ExUns: 20

Relevant External Links for CDC45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC45 Gene

This gene is overexpressed in Testis (x14.5).

Protein differential expression in normal tissues from HIPED for CDC45 Gene

This gene is overexpressed in Testis (61.8) and Fetal ovary (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC45 Gene

Protein tissue co-expression partners for CDC45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC45 Gene:


SOURCE GeneReport for Unigene cluster for CDC45 Gene:


mRNA Expression by UniProt/SwissProt for CDC45 Gene:

Tissue specificity: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.

Evidence on tissue expression from TISSUES for CDC45 Gene

  • Lung(4.2)
  • Nervous system(4.1)
  • Muscle(4)
genes like me logo Genes that share expression patterns with CDC45: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC45 Gene

Orthologs for CDC45 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC45 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia CDC45 33 34
  • 89.28 (n)
(Mus musculus)
Mammalia Cdc45 33 16 34
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Cdc45 33
  • 87.99 (n)
(Bos Taurus)
Mammalia CDC45 33
  • 87.02 (n)
CDC45L 34
  • 83 (a)
(Monodelphis domestica)
Mammalia CDC45 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CDC45 34
  • 68 (a)
(Gallus gallus)
Aves CDC45 33 34
  • 76.74 (n)
(Anolis carolinensis)
Reptilia CDC45 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc45 33
  • 74.56 (n)
Str.6579 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398081 33
(Danio rerio)
Actinopterygii cdc45 33 34
  • 71.97 (n)
wufi05h01 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011961 33
  • 51.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CDC45L 33 34
  • 50.54 (n)
(Caenorhabditis elegans)
Secernentea F34D10.2 33
  • 42.95 (n)
evl-18 34
  • 28 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR071C 33
  • 44.42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC45 33 34 36
  • 41.7 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19822g 33
  • 41.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC45 33
  • 43.8 (n)
(Oryza sativa)
Liliopsida Os11g0128400 33
  • 45.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc45 33
  • 43.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04378 33
  • 42.9 (n)
Species where no ortholog for CDC45 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC45 Gene

Gene Tree for CDC45 (if available)
Gene Tree for CDC45 (if available)

Paralogs for CDC45 Gene

No data available for Paralogs for CDC45 Gene

Variants for CDC45 Gene

Sequence variations from dbSNP and Humsavar for CDC45 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs146559223 Pathogenic 19,507,454(+) CGCAG(A/C/T)CAGGT nc-transcript-variant, reference, missense
rs540217942 Pathogenic 19,483,988(+) AGAAG(C/T)GCACA nc-transcript-variant, reference, missense
rs745800041 Pathogenic 19,482,803(+) AATGT(C/T)GTCAA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs748749078 Pathogenic 19,482,818(+) TACAA(C/T)GATAC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs754080445 Pathogenic 19,499,124(+) AACAG(A/G)CCAGT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDC45 Gene

Variant ID Type Subtype PubMed ID
nsv834127 CNV loss 17160897
nsv588216 CNV gain 21841781
nsv3558 CNV insertion 18451855
esv3893434 CNV gain 25118596
esv3575418 CNV gain 25503493
esv2751940 CNV gain 17911159
dgv4478n100 CNV loss 25217958

Variation tolerance for CDC45 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC45 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC45 Gene

Disorders for CDC45 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDC45 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meier-gorlin syndrome 7
  • mgors7
meier-gorlin syndrome 1
  • meier-gorlin syndrome
rothmund-thomson syndrome
  • congenital poikiloderma
- elite association - COSMIC cancer census association via MalaCards
Search CDC45 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC45

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDC45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC45 Gene

Publications for CDC45 Gene

  1. The human homolog of Saccharomyces cerevisiae CDC45. (PMID: 9660782) Saha P … Dutta A (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. (PMID: 9724329) McKie JM … Scambler PJ (Genome research 1998) 2 3 4 22 60
  3. Human Cdc45 is a proliferation-associated antigen. (PMID: 17608804) Pollok S … Grosse F (The FEBS journal 2007) 2 3 22 60
  4. Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin. (PMID: 25933514) Gerhardt J … Fanning E (Experimental cell research 2015) 3 4 60
  5. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. (PMID: 20065034) Chowdhury A … Leffak M (Molecular and cellular biology 2010) 3 22 60

Products for CDC45 Gene

Sources for CDC45 Gene

Loading form....