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Aliases for CDC45 Gene

Aliases for CDC45 Gene

  • Cell Division Cycle 45 2 3
  • CDC45L2 3 4 6
  • CDC45L 3 4 6
  • Human CDC45 2 3
  • PORC-PI-1 3 4
  • CDC45 (Cell Division Cycle 45, S.Cerevisiae, Homolog)-Like 2
  • CDC45 Cell Division Cycle 45-Like (S. Cerevisiae) 2
  • Cell Division Cycle 45 Homolog (S. Cerevisiae) 2
  • Cell Division Control Protein 45 Homolog 3
  • CDC45 Cell Division Cycle 45 Homolog 3
  • Cell Division Cycle 45 Homolog 3
  • Cell Division Cycle 45-Like 2 3
  • CDC45-Related Protein 3

External Ids for CDC45 Gene

Previous HGNC Symbols for CDC45 Gene

  • CDC45L2
  • CDC45L

Previous GeneCards Identifiers for CDC45 Gene

  • GC22P003088

Summaries for CDC45 Gene

Entrez Gene Summary for CDC45 Gene

  • The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CDC45 Gene

CDC45 (Cell Division Cycle 45) is a Protein Coding gene. Diseases associated with CDC45 include rothmund-thomson syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CDC45 Gene

  • Required for initiation of chromosomal DNA replication

Gene Wiki entry for CDC45 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC45 Gene

Genomics for CDC45 Gene

Genomic Location for CDC45 Gene

Start:
19,479,459 bp from pter
End:
19,520,612 bp from pter
Size:
41,154 bases
Orientation:
Plus strand

Genomic View for CDC45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC45 Gene

No data available for Regulatory Elements for CDC45 Gene

Proteins for CDC45 Gene

  • Protein details for CDC45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75419-CDC45_HUMAN
    Recommended name:
    Cell division control protein 45 homolog
    Protein Accession:
    O75419
    Secondary Accessions:
    • B4DDB4
    • B4DDU3
    • E9PDH7
    • O60856
    • Q20WK8
    • Q6UW54
    • Q9UP68

    Protein attributes for CDC45 Gene

    Size:
    566 amino acids
    Molecular mass:
    65569 Da
    Quaternary structure:
    • Associated with ORC2

    Alternative splice isoforms for CDC45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC45 Gene

Proteomics data for CDC45 Gene at MOPED

Post-translational modifications for CDC45 Gene

  • Ubiquitination at Lys8, Lys237, Lys337, Lys350, Lys411, and Lys528
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC45 Gene

No data available for DME Specific Peptides for CDC45 Gene

Domains for CDC45 Gene

Protein Domains for CDC45 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC45 Gene

Graphical View of Domain Structure for InterPro Entry

O75419

UniProtKB/Swiss-Prot:

CDC45_HUMAN :
  • O75419
Family:
  • Belongs to the CDC45 family.
genes like me logo Genes that share domains with CDC45: view

No data available for Gene Families for CDC45 Gene

Function for CDC45 Gene

Molecular function for CDC45 Gene

UniProtKB/Swiss-Prot Function: Required for initiation of chromosomal DNA replication

Gene Ontology (GO) - Molecular Function for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0003688 DNA replication origin binding IBA --
GO:0003697 single-stranded DNA binding IBA --
GO:0005515 protein binding IPI 10518787
GO:0043138 3-5 DNA helicase activity IBA --
genes like me logo Genes that share ontologies with CDC45: view
genes like me logo Genes that share phenotypes with CDC45: view

Animal Models for CDC45 Gene

MGI Knock Outs for CDC45:

miRNA for CDC45 Gene

miRTarBase miRNAs that target CDC45

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDC45 Gene

Localization for CDC45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC45 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC45 Gene COMPARTMENTS Subcellular localization image for CDC45 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005656 nuclear pre-replicative complex IBA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CDC45: view

Pathways for CDC45 Gene

genes like me logo Genes that share pathways with CDC45: view

Pathways by source for CDC45 Gene

1 Qiagen pathway for CDC45 Gene
1 Cell Signaling Technology pathway for CDC45 Gene
4 BioSystems pathways for CDC45 Gene
1 KEGG pathway for CDC45 Gene
1 GeneGo (Thomson Reuters) pathway for CDC45 Gene

Gene Ontology (GO) - Biological Process for CDC45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint TAS 9660782
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA --
genes like me logo Genes that share ontologies with CDC45: view

Compounds for CDC45 Gene

(1) Novoseek inferred chemical compound relationships for CDC45 Gene

Compound -log(P) Hits PubMed IDs
okadaic acid 36.7 2
genes like me logo Genes that share compounds with CDC45: view

Transcripts for CDC45 Gene

Unigene Clusters for CDC45 Gene

Cell division cycle 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC45 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - -
SP3:
SP4:
SP5:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CDC45 Gene

GeneLoc Exon Structure for
CDC45
ECgene alternative splicing isoforms for
CDC45

Expression for CDC45 Gene

mRNA expression in normal human tissues for CDC45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC45 Gene

This gene is overexpressed in Testis (14.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC45 Gene

SOURCE GeneReport for Unigene cluster for CDC45 Gene Hs.474217

mRNA Expression by UniProt/SwissProt for CDC45 Gene

O75419-CDC45_HUMAN
Tissue specificity: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver
genes like me logo Genes that share expressions with CDC45: view

Orthologs for CDC45 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC45 35
  • 99.28 (n)
  • 99.5 (a)
CDC45 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC45 35
  • 87.02 (n)
  • 90.62 (a)
CDC45L 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC45 35
  • 89.28 (n)
  • 92.4 (a)
CDC45 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc45 35
  • 88.1 (n)
  • 91.7 (a)
Cdc45 16
Cdc45 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC45 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC45 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc45 35
  • 87.99 (n)
  • 91.7 (a)
chicken
(Gallus gallus)
Aves CDC45 35
  • 76.74 (n)
  • 83.22 (a)
CDC45 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC45 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398081 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc45 35
  • 74.56 (n)
  • 79.33 (a)
Str.6579 35
zebrafish
(Danio rerio)
Actinopterygii cdc45 35
  • 71.97 (n)
  • 75.09 (a)
cdc45 36
  • 73 (a)
OneToOne
wufi05h01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011961 35
  • 51.89 (n)
  • 42.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CDC45L 35
  • 50.54 (n)
  • 41.58 (a)
CDC45L 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea evl-18 36
  • 28 (a)
OneToOne
F34D10.2 35
  • 42.95 (n)
  • 31.43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR071C 35
  • 44.42 (n)
  • 30.68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC45 35
  • 41.7 (n)
  • 30.07 (a)
CDC45 36
  • 25 (a)
OneToOne
CDC45 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19822g 35
  • 41.18 (n)
  • 28.99 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC45 35
  • 43.8 (n)
  • 32.71 (a)
rice
(Oryza sativa)
Liliopsida Os11g0128400 35
  • 45.53 (n)
  • 32.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04378 35
  • 42.9 (n)
  • 33.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc45 35
  • 43.96 (n)
  • 33.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for CDC45:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC45 Gene

ENSEMBL:
Gene Tree for CDC45 (if available)
TreeFam:
Gene Tree for CDC45 (if available)

Paralogs for CDC45 Gene

No data available for Paralogs for CDC45 Gene

Variants for CDC45 Gene

Sequence variations from dbSNP and Humsavar for CDC45 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs737858 -- 19,484,086(-) CACCT(C/T)GGCCT intron-variant
rs1002109 -- 19,502,817(+) AATCT(C/G)CAAGT intron-variant
rs1002110 -- 19,502,847(+) GACAG(A/T)GAGTC intron-variant
rs1002111 -- 19,503,116(+) gagct(A/G)tgatt intron-variant
rs1548359 -- 19,515,751(+) AAGAT(C/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC45 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv914263 CNV Gain 21882294
nsv834127 CNV Loss 17160897
dgv4840n71 CNV Loss 21882294
esv2751940 CNV Gain 17911159
nsv3558 CNV Insertion 18451855

Relevant External Links for CDC45 Gene

HapMap Linkage Disequilibrium report
CDC45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC45 Gene

Disorders for CDC45 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDC45 Gene including...

Search for CDC45 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CDC45 Gene

(1) Novoseek inferred disease relationships for CDC45 Gene

Disease -log(P) Hits PubMed IDs
digeorge syndrome 68.1 2

Relevant External Links for CDC45

Human Genome Epidemiology (HuGE) Navigator
CDC45
genes like me logo Genes that share disorders with CDC45: view

No data available for UniProtKB/Swiss-Prot for CDC45 Gene

Publications for CDC45 Gene

  1. The human homolog of Saccharomyces cerevisiae CDC45. (PMID: 9660782) Saha P. … Dutta A. (J. Biol. Chem. 1998) 2 3 4 23
  2. Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. (PMID: 9724329) McKie J.M. … Scambler P.J. (Genome Res. 1998) 2 3 4 23
  3. Human Cdc45 is a proliferation-associated antigen. (PMID: 17608804) Pollok S. … Grosse F. (FEBS J. 2007) 2 3 23
  4. Molecular architecture of the human GINS complex. (PMID: 17557111) Boskovic J. … Montoya G. (EMBO Rep. 2007) 3 23
  5. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. (PMID: 17046832) Masai H. … Arai K. (J. Biol. Chem. 2006) 3 23

Products for CDC45 Gene

Sources for CDC45 Gene

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