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Aliases for CDC42SE2 Gene

Aliases for CDC42SE2 Gene

  • CDC42 Small Effector 2 2 3
  • Small Effector Of CDC42 Protein 2 3 4
  • SPEC2 3 4
  • Non-Kinase Cdc42 Effector Protein SPEC2 3
  • CDC42 Small Effector Protein 2 3

External Ids for CDC42SE2 Gene

Previous GeneCards Identifiers for CDC42SE2 Gene

  • GC00U916970
  • GC05P130627
  • GC05P125790
  • GC05P130581

Summaries for CDC42SE2 Gene

GeneCards Summary for CDC42SE2 Gene

CDC42SE2 (CDC42 Small Effector 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CDC42SE1.

UniProtKB/Swiss-Prot for CDC42SE2 Gene

  • Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42SE2 Gene

Genomics for CDC42SE2 Gene

Regulatory Elements for CDC42SE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42SE2 Gene

Start:
131,245,493 bp from pter
End:
131,398,447 bp from pter
Size:
152,955 bases
Orientation:
Plus strand

Genomic View for CDC42SE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42SE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42SE2 Gene

Proteins for CDC42SE2 Gene

  • Protein details for CDC42SE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR3-C42S2_HUMAN
    Recommended name:
    CDC42 small effector protein 2
    Protein Accession:
    Q9NRR3
    Secondary Accessions:
    • B2R622
    • Q4KMT9

    Protein attributes for CDC42SE2 Gene

    Size:
    84 amino acids
    Molecular mass:
    9223 Da
    Quaternary structure:
    • Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
    Miscellaneous:
    • CDC42SE2 is mapped in the genomic region associated with schizophrenia

neXtProt entry for CDC42SE2 Gene

Proteomics data for CDC42SE2 Gene at MOPED

Post-translational modifications for CDC42SE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42SE2 Gene

No data available for DME Specific Peptides for CDC42SE2 Gene

Domains for CDC42SE2 Gene

Protein Domains for CDC42SE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC42SE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRR3

UniProtKB/Swiss-Prot:

C42S2_HUMAN :
  • Q9NRR3
Domain:
  • The CRIB domain mediates interaction with CDC42
  • Contains 1 CRIB domain.
Family:
  • Belongs to the CDC42SE/SPEC family.
genes like me logo Genes that share domains with CDC42SE2: view

No data available for Gene Families for CDC42SE2 Gene

Function for CDC42SE2 Gene

Molecular function for CDC42SE2 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

Gene Ontology (GO) - Molecular Function for CDC42SE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IDA 10816584
GO:0005515 protein binding IPI 10816584
genes like me logo Genes that share ontologies with CDC42SE2: view

Phenotypes for CDC42SE2 Gene

GenomeRNAi human phenotypes for CDC42SE2:
genes like me logo Genes that share phenotypes with CDC42SE2: view

Animal Model Products

CRISPR Products

miRNA for CDC42SE2 Gene

miRTarBase miRNAs that target CDC42SE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42SE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42SE2 Gene

Localization for CDC42SE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42SE2 Gene

Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42SE2 Gene COMPARTMENTS Subcellular localization image for CDC42SE2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
nucleus 4
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for CDC42SE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 10816584
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CDC42SE2: view

Pathways for CDC42SE2 Gene

SuperPathways for CDC42SE2 Gene

No Data Available

Interacting Proteins for CDC42SE2 Gene

Gene Ontology (GO) - Biological Process for CDC42SE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0008360 regulation of cell shape IEA --
GO:0009966 regulation of signal transduction IDA 10816584
genes like me logo Genes that share ontologies with CDC42SE2: view

No data available for Pathways by source for CDC42SE2 Gene

Compounds for CDC42SE2 Gene

(1) HMDB Compounds for CDC42SE2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CDC42SE2: view

Transcripts for CDC42SE2 Gene

Unigene Clusters for CDC42SE2 Gene

CDC42 small effector 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42SE2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42SE2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CDC42SE2 Gene

GeneLoc Exon Structure for
CDC42SE2
ECgene alternative splicing isoforms for
CDC42SE2

Expression for CDC42SE2 Gene

mRNA expression in normal human tissues for CDC42SE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42SE2 Gene

SOURCE GeneReport for Unigene cluster for CDC42SE2 Gene Hs.508829

mRNA Expression by UniProt/SwissProt for CDC42SE2 Gene

Q9NRR3-C42S2_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
genes like me logo Genes that share expressions with CDC42SE2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDC42SE2 Gene

Orthologs for CDC42SE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42SE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42SE2 35
  • 100 (n)
  • 100 (a)
CDC42SE2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42SE2 35
  • 88.49 (n)
  • 98.81 (a)
CDC42SE2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42SE2 35
  • 90.48 (n)
  • 97.62 (a)
CDC42SE2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42se2 35
  • 90.87 (n)
  • 100 (a)
Cdc42se2 16
Cdc42se2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42SE2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362023 35
  • 89.29 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CDC42SE2 35
  • 88.1 (n)
  • 96.43 (a)
CDC42SE2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42SE2 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16447 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42se2 35
  • 86.51 (n)
  • 97.62 (a)
Str.1828 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.398 35
zebrafish
(Danio rerio)
Actinopterygii CDC42SE2 36
  • 91 (a)
OneToOne
zgc:172116 35
  • 80.95 (n)
  • 94.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spec2 36
  • 46 (a)
OneToMany
Species with no ortholog for CDC42SE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42SE2 Gene

ENSEMBL:
Gene Tree for CDC42SE2 (if available)
TreeFam:
Gene Tree for CDC42SE2 (if available)

Paralogs for CDC42SE2 Gene

Paralogs for CDC42SE2 Gene

Selected SIMAP similar genes for CDC42SE2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDC42SE2: view

Variants for CDC42SE2 Gene

Sequence variations from dbSNP and Humsavar for CDC42SE2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3488 -- 131,393,922(+) TACTC(A/T)GCAGC utr-variant-3-prime
rs30733 -- 131,369,263(-) TAAAA(A/T)TTAGC intron-variant
rs30734 -- 131,370,762(-) TTAAT(A/C)ATTAG intron-variant
rs30735 -- 131,373,729(-) gtttt(C/T)tgttt intron-variant
rs30736 -- 131,388,547(+) ATATT(A/G)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42SE2 Gene

Variant ID Type Subtype PubMed ID
nsv882884 CNV Loss 21882294
nsv524005 CNV Loss 19592680
esv2458941 CNV Deletion 19546169
esv2445763 CNV Insertion 19546169
esv1652370 CNV Deletion 17803354
nsv882888 CNV Loss 21882294
nsv528481 CNV Loss 19592680

Relevant External Links for CDC42SE2 Gene

HapMap Linkage Disequilibrium report
CDC42SE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42SE2 Gene

Disorders for CDC42SE2 Gene

Relevant External Links for CDC42SE2

Genetic Association Database (GAD)
CDC42SE2
Human Genome Epidemiology (HuGE) Navigator
CDC42SE2
genes like me logo Genes that share disorders with CDC42SE2: view

No data available for UniProtKB/Swiss-Prot for CDC42SE2 Gene

Publications for CDC42SE2 Gene

  1. SPECs, small binding proteins for Cdc42. (PMID: 10816584) Pirone D.M. … Burbelo P.D. (J. Biol. Chem. 2000) 2 3 4
  2. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. (PMID: 15840583) Ching K.H. … Burbelo P.D. (J. Biol. Chem. 2005) 3 4 23
  3. Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. (PMID: 17030554) Chen X. … Kendler K.S. (Hum. Mol. Genet. 2006) 3 4 48
  4. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PMID: 18804346) Edwards T.L. … Chen X. (Schizophr. Res. 2008) 3 48
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CDC42SE2 Gene

Sources for CDC42SE2 Gene

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