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CDC42SE2 Gene

protein-coding   GIFtS: 52
GCID: GC05P130581

CDC42 Small Effector 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CDC42 Small Effector 21 2
Small Effector Of CDC42 Protein 22 3
SPEC22 3
CDC42 Small Effector Protein 22
Non-Kinase Cdc42 Effector Protein SPEC22

External Ids:    HGNC: 185471   Entrez Gene: 569902   Ensembl: ENSG000001589857   UniProtKB: Q9NRR33   
ORGUL members:         

Export aliases for CDC42SE2 gene to outside databases

Previous GC identifers: GC00U916970 GC05P130627 GC05P125790


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDC42SE2 Gene:
CDC42SE2 (CDC42 small effector 2) is a protein-coding gene. Diseases associated with CDC42SE2 include papillary adenocarcinoma, and endometrial adenocarcinoma. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is CDC42SE1.

UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3
Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing
actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in
CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in
phagocytosis in macrophages




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42SE2 gene promoter:
         TBP   STAT1   STAT4   STAT1beta   STAT1alpha   Evi-1   c-Ets-1   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC42SE2 promoter sequence
   Search Chromatin IP Primers for CDC42SE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42SE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q23.3   HGNC cytogenetic band: 5q31.1

CDC42SE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42SE2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P130581:  view genomic region     (about GC identifiers)

Start:
130,581,186 bp from pter      End:
130,734,140 bp from pter
Size:
152,955 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3 (See protein sequence)
Recommended Name: CDC42 small effector protein 2  
Size: 84 amino acids; 9223 Da
Subunit: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA
Miscellaneous: CDC42SE2 is mapped in the genomic region associated with schizophrenia
Secondary accessions: B2R622 Q4KMT9

Explore the universe of human proteins at neXtProt for CDC42SE2: NX_Q9NRR3

Explore proteomics data for CDC42SE2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC42SE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001033791.1  NP_064625.1  

    ENSEMBL proteins: 
     ENSP00000426779   ENSP00000353706   ENSP00000427421   ENSP00000425292   ENSP00000378667  

    CDC42SE2 Human Recombinant Protein Products:

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    Novus Biologicals CDC42SE2 Protein
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRR3

    ProtoNet protein and cluster: Q9NRR3

    UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3
    Domain: The CRIB domain mediates interaction with CDC42
    Similarity: Belongs to the CDC42SE/SPEC family
    Similarity: Contains 1 CRIB domain


    CDC42SE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C42S2_HUMAN, Q9NRR3
    Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing
    actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in
    CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in
    phagocytosis in macrophages

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IDA10816584
    GO:0005515protein binding IPI10816584
         
    CDC42SE2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC42SE2:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC42SE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC42SE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC42SE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC42SE2

    miRNA
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    miRTarBase miRNAs that target CDC42SE2:
    hsa-mir-421 (MIRT039379)

    Block miRNA regulation of human, mouse, rat CDC42SE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42SE2 (see all 53):
    hsa-miR-3664-5p hsa-miR-4272 hsa-miR-15a hsa-miR-503 hsa-miR-371-5p hsa-miR-218 hsa-miR-570 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCDC42SE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDC42SE2
    Predesigned siRNA for gene silencing in human, mouse, rat CDC42SE2

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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC42SE2 (NM_020240)
    Sino Biological Human cDNA Clone for CDC42SE2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C42S2_HUMAN, Q9NRR3: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup.
    Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    nucleus4
    cytosol2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IDA10816584

    CDC42SE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC42SE2
    Interactions:

        Search GeneGlobe Interaction Network for CDC42SE2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CDC42SE2 (Q9NRR33 ENSP000003537064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0008360regulation of cell shape IEA--
    GO:0009966regulation of signal transduction IDA10816584

    CDC42SE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC42SE2 (C42S2)

    1 HMDB Compound for CDC42SE2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC42SE2 gene (2 alternative transcripts): 
    NM_001038702.1  NM_020240.2  

    Unigene Cluster for CDC42SE2:

    CDC42 small effector 2
    Hs.508829  [show with all ESTs]
    Unigene Representative Sequence: BC058909
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502840 ENST00000511432 ENST00000515533 ENST00000506419 ENST00000504701
    ENST00000503291 ENST00000360515(uc003kvi.3 uc003kvk.3) ENST00000505065(uc003kvh.3)
    ENST00000502582 ENST00000506929 ENST00000502639 ENST00000395246(uc003kvj.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat CDC42SE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42SE2 (see all 53):
    hsa-miR-3664-5p hsa-miR-4272 hsa-miR-15a hsa-miR-503 hsa-miR-371-5p hsa-miR-218 hsa-miR-570 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidCDC42SE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDC42SE2
    Predesigned siRNA for gene silencing in human, mouse, rat CDC42SE2
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    OriGene ORF clones in mouse, rat for CDC42SE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDC42SE2 (NM_020240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42SE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE2
    Primer
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    OriGene qPCR primer pairs and template standards for CDC42SE2
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC42SE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC42SE2
      QuantiTect SYBR Green Assays in human, mouse, rat CDC42SE2
      QuantiFast Probe-based Assays in human, mouse, rat CDC42SE2

    Additional mRNA sequence: 

    AF131831.1 AF189692.1 AK025620.1 AK312406.1 BC023555.2 BC050430.1 BC058909.1 BC096703.1 
    BC096738.1 BC098349.1 

    14 DOTS entries:

    DT.92021416  DT.92437197  DT.100824836  DT.100824845  DT.100824846  DT.100026524  DT.101957741  DT.100824844 
    DT.99929388  DT.101986587  DT.86807558  DT.120850324  DT.120850400  DT.95342688 

    Selected AceView cDNA sequences (see all 333):

    BM479470 CF243193 AA361643 NM_020240 BQ007919 BM740466 BI756734 AA232762 
    BQ232988 CA428918 AW071512 AW073769 AI797435 CR626635 AI537319 AA724601 
    BU902743 CA314855 AW628877 AW273100 BC050430 BU162384 BI771024 Z45477 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC42SE2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                              -         
    SP2:                                      -                       -         
    SP3:                                      -                                 
    SP4:                          -           -                                 


    ECgene alternative splicing isoforms for CDC42SE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42SE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGGTGCC
    CDC42SE2 Expression
    About this image

    CDC42SE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42SE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508829

    UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3
    Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM
    T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDC42SE2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42se21 , 5 CDC42 small effector 21, 5 90.87(n)1
    100(a)1
      11 (32.13 cM)5
    727291  NM_178626.31  NP_848741.11 
     547174565 
    chicken
    (Gallus gallus)
    Aves CDC42SE21 CDC42 small effector 2 88.1(n)
    96.43(a)
      768825  XM_004949254.1  XP_004949311.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42SE26
    CDC42 small effector 2
    98(a)
    1 ↔ 1
    2(31445365-31452735)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164472 Xenopus laevis transcribed sequences 89.89(n)    BJ616651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1721161 zgc:172116 80.95(n)
    94.05(a)
      794234  NM_001159835.1  NP_001153307.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spec26
    Spec2
    46(a)
    1 → many
    3R(1442368-1449803)


    ENSEMBL Gene Tree for CDC42SE2 (if available)
    TreeFam Gene Tree for CDC42SE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC42SE2 gene
    CDC42SE12  
    1 SIMAP similar gene for CDC42SE2 using alignment to 3 protein entries:     C42S2_HUMAN (see all proteins):
    CDC42SE1

    CDC42SE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42SE2 (see all 2460)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017417761,2
    C--130597873(+) TTTTTG/TTTCTA 2 -- us2k10--------
    rs1167578001,2
    C,F--130597962(+) GTAGCG/ATATCA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs342149921,2
    C--130598107(+) AAAAA-/ATTGGT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs112420691,2
    C,F,A,H--130598318(+) GGACCC/ACGACC 2 -- us2k120Minor allele frequency- A:0.43NS EA NA WA CSA 2328
    rs1431444711,2
    --130598320(+) ACCACG/TACCAG 2 -- us2k10--------
    rs1482378941,2
    --130598342(+) TCTCAG/TGTCTC 2 -- us2k10--------
    rs1864802361,2
    --130598375(+) TGCACA/GTAACC 2 -- us2k10--------
    rs1996400201,2
    --130598493(+) TTGTG-/TTTTTT 2 -- us2k10--------
    rs107080761,2
    C--130598649(+) GAGAA-/TTTTTT 2 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs1418601551,2
    --130598736(+) ACTCCA/TGGCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC42SE2 (130581186 - 130734140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDC42SE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1652370CNV Deletion17803354
    esv2458941CNV Deletion19546169
    esv2445763CNV Insertion19546169
    nsv528481CNV Loss19592680
    nsv882884CNV Loss21882294
    nsv524005CNV Loss19592680
    nsv882888CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC42SE2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC42SE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    7 diseases for CDC42SE2:    
    About MalaCards
    papillary adenocarcinoma    endometrial adenocarcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    endometrial carcinoma    schizophrenia    adenocarcinoma


    CDC42SE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDC42SE2
    Human Genome Epidemiology (HuGE) Navigator: CDC42SE2 (2 documents)

    Export disorders for CDC42SE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42SE2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with CDC42SE2)
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    world of online information

    1. Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. (PubMed id 17030554)1, 2, 4 Chen X.... Kendler K.S. (Hum. Mol. Genet. 2006)
    2. SPECs, small binding proteins for Cdc42. (PubMed id 10816584)1, 2, 3 Pirone D.M.... Burbelo P.D. (J. Biol. Chem. 2000)
    3. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. (PubMed id 15840583)1, 2, 9 Ching K.H.... Burbelo P.D. (J. Biol. Chem. 2005)
    4. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PubMed id 18804346)1, 4 Edwards T.L....Chen X. (Schizophr. Res. 2008)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Regulation of Cdc42 expression and signaling is critical for promoting corneal epithelial wound healing. (PubMed id 23833064)1 Pothula S....Chandrasekher G. (amp 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56990 HGNC: 18547 AceView: CDC42SE2 Ensembl:ENSG00000158985 euGenes: HUgn56990
    ECgene: CDC42SE2 H-InvDB: CDC42SE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC42SE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC42SE2 gene:
    Search GeneIP for patents involving CDC42SE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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