CDC42SE2 Gene
protein-coding GIFtS: 48
GCID: GC05P130581
|
|
CDC42 small effector 2
| |
Aliases
for CDC42SE2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDC42 Small Effector 21 2 | | SPEC21 2 3 | | Small Effector Of CDC42 Protein 22 3 | | FLJ219671 | | CDC42 Small Effector Protein 22 | | Non-Kinase Cdc42 Effector Protein SPEC22 |
Export aliases for CDC42SE2 gene to outside databasesPrevious GC identifers: GC00U916970 GC05P130627 GC05P125790 |
Summaries
for CDC42SE2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actinfilament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediatedF-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis inmacrophages
|
Genomic Views
for CDC42SE2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC42SE2 gene promoter:
TBP STAT1 STAT4 STAT1beta STAT1alpha Evi-1 c-Ets-1 AREB6 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC42SE2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42SE2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q23.3 HGNC cytogenetic band: 5q31.1CDC42SE2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P130581: view genomic region
(about GC identifiers)
Start:
|
130,581,186 bp from pter |
End:
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130,734,140 bp from pter |
Size:
|
152,955 bases |
Orientation:
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plus strand |
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Proteins
for CDC42SE2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3 (See
protein sequence)Recommended Name: CDC42 small effector protein 2 Size: 84 amino acids; 9223 Da
Subunit: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA
Subcellular location: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup.Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages
Miscellaneous: CDC42SE2 is mapped in the genomic region associated with schizophrenia
Secondary accessions: B2R622 Q4KMT9Explore the universe of human proteins at neXtProt for CDC42SE2: NX_Q9NRR3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRR3
CDC42SE2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001033791.1 NP_064625.1
ENSEMBL proteins: ENSP00000426779 ENSP00000353706 ENSP00000427421 ENSP00000425292 ENSP00000378667
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CDC42SE2 for ontologies About GeneDecksing
CDC42SE2 Antibody Products:
Assay Products for CDC42SE2: |
Protein
Domains /
Families
for CDC42SE2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDC42SE2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NRR3ProtoNet protein and cluster: Q9NRR3 UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3Domain: The CRIB domain mediates interaction with CDC42Similarity: Belongs to the CDC42SE/SPEC familySimilarity: Contains 1 CRIB domain |
Function
for CDC42SE2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actinfilament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediatedF-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis inmacrophages
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42SE2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42SE2 (see all 2)
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Synthesis Service for CDC42SE2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CDC42SE2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CDC42SE2:
|
Pathways & Interactions
for CDC42SE2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC42SE2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for CDC42SE2 (Q9NRR33 ENSP000003537064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CDC42SE2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDC42SE2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDC42SE2
1 HMDB Compound for CDC42SE2 About this table
Search CenterWatch for drugs/clinical trials and news about CDC42SE2 / C42S2
|
Transcripts
for CDC42SE2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDC42SE2 gene (2 alternative transcripts): NM_001038702.1 NM_020240.2 Unigene Cluster for CDC42SE2: CDC42 small effector 2 Hs.508829 [show with all ESTs]Unigene Representative Sequence: BC05890912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000502840 ENST00000511432 ENST00000515533 ENST00000506419 ENST00000504701
ENST00000503291 ENST00000360515(uc003kvi.3 uc003kvk.3) ENST00000505065(uc003kvh.3)
ENST00000502582 ENST00000506929 ENST00000502639 ENST00000395246(uc003kvj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42SE2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42SE2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CDC42SE2 (NM_020240) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC42SE2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE2 |
Additional cDNA sequence: AF131831.1 AF189692.1 AK025620.1 AK312406.1 BC023555.2 BC050430.1 BC058909.1 BC096703.1 BC096738.1 BC098349.1 14 DOTS entries: DT.92021416 DT.100824836 DT.92437197 DT.100824845 DT.100824846 DT.100026524 DT.101957741 DT.100824844 DT.99929388 DT.101986587 DT.120850324 DT.120850400 DT.86807558 DT.95342688 24/333 AceView cDNA sequences (see all 333): AW264004 BC050430 BM479470 AI797435 R87625 AI440226 BQ232988 BQ007919 F07614 BQ879330 AI580170 BM740466 R45661 AA516010 AI537319 AA724601 AW073769 AA807536 BU192320 BI756734 F03130 Z45477 BU681917 CR626635
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC42SE2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDC42SE2
|
Expression
for CDC42SE2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC42SE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTGGTGCC
About this image
See CDC42SE2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC42SE2
SOURCE GeneReport for Unigene cluster: Hs.508829
UniProtKB/Swiss-Prot: C42S2_HUMAN, Q9NRR3Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEMT-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level)
SABiosciences Custom PCR Arrays for CDC42SE2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42SE2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDC42SE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42SE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42SE2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE2 |
Orthologs
for CDC42SE2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDC42SE2 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for CDC42SE2 (if available)
TreeFam Gene Tree for CDC42SE2 (if available) |
Paralogs
for CDC42SE2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDC42SE2 gene
- CDC42SE12
1 SIMAP similar gene for CDC42SE2 using alignment to 3 protein entries: C42S2_HUMAN (see all proteins):CDC42SE1
CDC42SE2 for paralogs About GeneDecksing
|
Genomic Variants
for CDC42SE2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDC42SE2 (130581186 - 130734140 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CDC42SE2
1 CNV: 99296
2 Indels: 99297 27800 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42SE2 |
|
Disorders
/ Diseases
for CDC42SE2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDC42SE2 for disorders About GeneDecksing
8  diseases for CDC42SE2: About MalaCardsintrahepatic cholangiocarcinoma endometrial carcinoma papillary adenocarcinoma endometrial adenocarcinoma
cholangiocarcinoma adenocarcinoma carcinoma schizophrenia
Human Genome Epidemiology (HuGE) Navigator: CDC42SE2 (2 documents)
Export disorders for CDC42SE2 gene to outside databases
|
Publications
for CDC42SE2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDC42SE2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with CDC42SE2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SPECs, small binding proteins for Cdc42. (PubMed id 10816584)1, 2, 3 Pirone D.M.... Burbelo P.D. (2000)
- The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. (PubMed id 15840583)1, 2, 9 Ching K.H.... Burbelo P.D. (2005)
- Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. (PubMed id 17030554)1, 2 Chen X.... Kendler K.S. (2006)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PubMed id 18804346)1 Edwards T.L....Chen X. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis. (PubMed id 17045588)2 Ching K.H.... Burbelo P.D. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
|
External Searches for CDC42SE2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDC42SE2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDC42SE2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDC42SE2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDC42SE2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDC42SE2 gene:
Search GeneIP for patents involving CDC42SE2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC42SE2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC42SE2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42SE2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42SE2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC42SE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42SE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42SE2 |
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 | | | CDC42SE2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CDC42SE2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE2 |
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