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Aliases for CDC42SE1 Gene

Aliases for CDC42SE1 Gene

  • CDC42 Small Effector 1 2 3
  • Small Effector Of CDC42 Protein 1 3 4
  • CDC42-Binding Protein SCIP1 3 4
  • SPEC1 3 4
  • Small Protein Effector 1 Of Cdc42 3
  • CDC42 Small Effector Protein 1 3
  • Signaling Molecule SPEC1 Beta 3
  • 1300002M12Rik 3
  • SCIP1 3

External Ids for CDC42SE1 Gene

Summaries for CDC42SE1 Gene

GeneCards Summary for CDC42SE1 Gene

CDC42SE1 (CDC42 Small Effector 1) is a Protein Coding gene. Diseases associated with CDC42SE1 include scarlet fever. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is CDC42SE2.

UniProtKB/Swiss-Prot for CDC42SE1 Gene

  • Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42SE1 Gene

Genomics for CDC42SE1 Gene

Genomic Location for CDC42SE1 Gene

Start:
151,050,971 bp from pter
End:
151,070,325 bp from pter
Size:
19,355 bases
Orientation:
Minus strand

Genomic View for CDC42SE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42SE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42SE1 Gene

Regulatory Elements for CDC42SE1 Gene

Proteins for CDC42SE1 Gene

  • Protein details for CDC42SE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR8-C42S1_HUMAN
    Recommended name:
    CDC42 small effector protein 1
    Protein Accession:
    Q9NRR8
    Secondary Accessions:
    • D3DV12
    • Q9HB17
    • Q9NQR2

    Protein attributes for CDC42SE1 Gene

    Size:
    79 amino acids
    Molecular mass:
    8925 Da
    Quaternary structure:
    • Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.

    Alternative splice isoforms for CDC42SE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC42SE1 Gene

Proteomics data for CDC42SE1 Gene at MOPED

Post-translational modifications for CDC42SE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42SE1 Gene

No data available for DME Specific Peptides for CDC42SE1 Gene

Domains for CDC42SE1 Gene

Protein Domains for CDC42SE1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

C42S1_HUMAN
Domain:
  • The CRIB domain mediates interaction with CDC42:
    • Q9NRR8
  • Contains 1 CRIB domain.:
    • Q9NRR8
Family:
  • Belongs to the CDC42SE/SPEC family.:
    • Q9NRR8
genes like me logo Genes that share domains with CDC42SE1: view

No data available for Gene Families for CDC42SE1 Gene

Function for CDC42SE1 Gene

Molecular function for CDC42SE1 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

Gene Ontology (GO) - Molecular Function for CDC42SE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 10816584
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with CDC42SE1: view

Phenotypes for CDC42SE1 Gene

GenomeRNAi human phenotypes for CDC42SE1:
genes like me logo Genes that share phenotypes with CDC42SE1: view

miRNA for CDC42SE1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42SE1 Gene

Localization for CDC42SE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42SE1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42SE1 Gene COMPARTMENTS Subcellular localization image for CDC42SE1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
mitochondrion 4
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42SE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CDC42SE1: view

Pathways for CDC42SE1 Gene

genes like me logo Genes that share pathways with CDC42SE1: view

Pathways by source for CDC42SE1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDC42SE1 Gene
1 Qiagen pathway for CDC42SE1 Gene

Gene Ontology (GO) - Biological Process for CDC42SE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0007165 signal transduction TAS 10816584
GO:0008360 regulation of cell shape IEA --
GO:0034260 negative regulation of GTPase activity TAS 10816584
GO:0043086 negative regulation of catalytic activity --
genes like me logo Genes that share ontologies with CDC42SE1: view

Compounds for CDC42SE1 Gene

(1) HMDB Compounds for CDC42SE1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CDC42SE1: view

Transcripts for CDC42SE1 Gene

Unigene Clusters for CDC42SE1 Gene

CDC42 small effector 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42SE1 Gene

No ASD Table

Relevant External Links for CDC42SE1 Gene

GeneLoc Exon Structure for
CDC42SE1
ECgene alternative splicing isoforms for
CDC42SE1

Expression for CDC42SE1 Gene

mRNA expression in normal human tissues for CDC42SE1 Gene

mRNA differential expression in normal tissues according to GTEx for CDC42SE1 Gene

This gene is overexpressed in Whole Blood (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42SE1 Gene

SOURCE GeneReport for Unigene cluster for CDC42SE1 Gene Hs.22065

mRNA Expression by UniProt/SwissProt for CDC42SE1 Gene

Q9NRR8-C42S1_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes, dendritic and whole blood cells.
genes like me logo Genes that share expressions with CDC42SE1: view

Orthologs for CDC42SE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42SE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42SE1 36
  • 99.58 (n)
  • 100 (a)
CDC42SE1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42SE1 36
  • 97.47 (n)
  • 100 (a)
CDC42SE1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42SE1 36
  • 94.51 (n)
  • 100 (a)
CDC42SE1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42se1 36
  • 91.56 (n)
  • 98.73 (a)
Cdc42se1 16
Cdc42se1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42SE1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42se1 36
  • 91.14 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves CDC42SE1 36
  • 76.07 (n)
  • 84.62 (a)
CDC42SE1 37
  • 83 (a)
OneToMany
CDC42SE1 37
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CDC42SE1 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42se1 36
  • 75.88 (n)
  • 84.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1155 36
zebrafish
(Danio rerio)
Actinopterygii cdc42se1 36
  • 71.87 (n)
  • 78.12 (a)
cdc42se1 37
  • 69 (a)
OneToOne
wufa55c04 36
fruit fly
(Drosophila melanogaster)
Insecta Spec2 37
  • 33 (a)
OneToMany
Species with no ortholog for CDC42SE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42SE1 Gene

ENSEMBL:
Gene Tree for CDC42SE1 (if available)
TreeFam:
Gene Tree for CDC42SE1 (if available)

Paralogs for CDC42SE1 Gene

Paralogs for CDC42SE1 Gene

Selected SIMAP similar genes for CDC42SE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42SE1: view

Variants for CDC42SE1 Gene

Sequence variations from dbSNP and Humsavar for CDC42SE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2864700 -- 151,056,453(+) CTGAA(C/T)GCCTA intron-variant
rs2902810 -- 151,054,339(+) AGATG(C/T)GAGAC intron-variant
rs3034000 -- 151,056,634(+) TCAGC(-/AGC)AGTTC intron-variant
rs3830607 -- 151,055,363(+) ACAAA(-/GAAA)GGACA intron-variant
rs5777754 -- 151,056,630(+) CCAGT(-/CAG)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42SE1 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680

Relevant External Links for CDC42SE1 Gene

HapMap Linkage Disequilibrium report
CDC42SE1

Disorders for CDC42SE1 Gene

(1) MalaCards Diseases for CDC42SE1 Gene

Search for CDC42SE1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDC42SE1 Gene

genes like me logo Genes that share disorders with CDC42SE1: view

No data available for UniProtKB/Swiss-Prot for CDC42SE1 Gene

Publications for CDC42SE1 Gene

  1. SPECs, small binding proteins for Cdc42. (PMID: 10816584) Pirone D.M. … Burbelo P.D. (J. Biol. Chem. 2000) 2 3 4
  2. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. (PMID: 15840583) Ching K.H. … Burbelo P.D. (J. Biol. Chem. 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins. (PMID: 18541383) Schnack C. … Gillardon F. (Neuroscience 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CDC42SE1 Gene

Sources for CDC42SE1 Gene

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