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CDC42SE1 Gene

protein-coding   GIFtS: 48
GCID: GC01M151023

CDC42 Small Effector 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC42 Small Effector 11 2     SCIP12
Small Effector Of CDC42 Protein 12 3     CDC42 Small Effector Protein 12
SPEC12 3     Signaling Molecule SPEC1 Beta2
CDC42-Binding Protein SCIP12 3     Small Protein Effector 1 Of Cdc422
1300002M12Rik2     

External Ids:    HGNC: 177191   Entrez Gene: 568822   Ensembl: ENSG000001976227   UniProtKB: Q9NRR83   

Export aliases for CDC42SE1 gene to outside databases

Previous GC identifers: GC00U916969 GC01M147837 GC01M149290 GC01M122400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDC42SE1 Gene:
CDC42SE1 (CDC42 small effector 1) is a protein-coding gene. Diseases associated with CDC42SE1 include scarlet fever, and schistosomiasis. GO annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is CDC42SE2.

UniProtKB/Swiss-Prot: C42S1_HUMAN, Q9NRR8
Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing
actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in
CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in
phagocytosis in macrophages




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42SE1 gene promoter:
         E2F-4   E2F-3a   Elk-1   E2F-5   HSF1 (long)   E2F-2   E2F   E2F-1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC42SE1 promoter sequence
   Search Chromatin IP Primers for CDC42SE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42SE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.1

CDC42SE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42SE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151023:  view genomic region     (about GC identifiers)

Start:
151,023,447 bp from pter      End:
151,042,801 bp from pter
Size:
19,355 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: C42S1_HUMAN, Q9NRR8 (See protein sequence)
Recommended Name: CDC42 small effector protein 1  
Size: 79 amino acids; 8925 Da
Subunit: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA
Secondary accessions: D3DV12 Q9HB17 Q9NQR2
Alternative splicing: 2 isoforms:  Q9NRR8-1   Q9NRR8-2   

Explore the universe of human proteins at neXtProt for CDC42SE1: NX_Q9NRR8

Explore proteomics data for CDC42SE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC42SE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001033796.1  NP_064624.1  

    ENSEMBL proteins: 
     ENSP00000475845   ENSP00000445647   ENSP00000349773  

    CDC42SE1 Human Recombinant Protein Products:

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    Novus Biologicals CDC42SE1 Lysates
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    CDC42SE1 Assay Products:

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    Cloud-Clone Corp. ELISAs for CDC42SE1
    Cloud-Clone Corp. CLIAs for CDC42SE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRR8

    ProtoNet protein and cluster: Q9NRR8

    UniProtKB/Swiss-Prot: C42S1_HUMAN, Q9NRR8
    Domain: The CRIB domain mediates interaction with CDC42
    Similarity: Belongs to the CDC42SE/SPEC family
    Similarity: Contains 1 CRIB domain


    CDC42SE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C42S1_HUMAN, Q9NRR8
    Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing
    actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in
    CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in
    phagocytosis in macrophages

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity TAS10816584
         
    CDC42SE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC42SE1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC42SE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC42SE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC42SE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC42SE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC42SE1:
    hsa-mir-29c-3p (MIRT020379), hsa-mir-92a-3p (MIRT049635), hsa-mir-320a (MIRT044634), hsa-mir-1 (MIRT024042)

    Block miRNA regulation of human, mouse, rat CDC42SE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42SE1 (see all 59):
    hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-371-5p hsa-miR-766 hsa-miR-877* hsa-miR-1273d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDC42SE1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC42SE1

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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC42SE1 (NM_001038707)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42SE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC42SE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C42S1_HUMAN, Q9NRR8: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR
    prior actin polymerization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    mitochondrion4
    cytosol3
    extracellular2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--

    CDC42SE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC42SE1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDC42SE1
        CDC42 Pathway

    1 GeneGo (Thomson Reuters) Pathway for CDC42SE1
        Cytoskeleton remodeling CDC42 in cellular processes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC42SE1
    Interactions:

        Search GeneGlobe Interaction Network for CDC42SE1

    3 Interacting proteins for CDC42SE1 (Q9NRR83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609533I2D: score=4 
    RAC1P630003I2D: score=2 
    SNCAP378403I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0007165signal transduction TAS10816584
    GO:0008360regulation of cell shape IEA--
    GO:0043086negative regulation of catalytic activity TAS10816584

    CDC42SE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC42SE1 (C42S1)

    1 HMDB Compound for CDC42SE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC42SE1 gene (2 alternative transcripts): 
    NM_001038707.1  NM_020239.3  

    Unigene Cluster for CDC42SE1:

    CDC42 small effector 1
    Hs.22065  [show with all ESTs]
    Unigene Representative Sequence: NM_001038707
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439374 ENST00000483763 ENST00000492796 ENST00000470278 ENST00000491825
    ENST00000540998(uc001ewo.3 uc001ewp.3) ENST00000357235
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDC42SE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42SE1 (see all 59):
    hsa-miR-1321 hsa-let-7d hsa-miR-29a hsa-miR-371-5p hsa-miR-766 hsa-miR-877* hsa-miR-1273d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDC42SE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDC42SE1
    Predesigned siRNA for gene silencing in human, mouse, rat CDC42SE1
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    OriGene ORF clones in mouse, rat for CDC42SE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDC42SE1 (NM_001038707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42SE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42SE1
    Primer
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    OriGene qPCR primer pairs and template standards for CDC42SE1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC42SE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC42SE1
      QuantiTect SYBR Green Assays in human, mouse, rat CDC42SE1
      QuantiFast Probe-based Assays in human, mouse, rat CDC42SE1

    Additional mRNA sequence: 

    AF187845.2 AF286041.1 AF286592.1 BC012796.2 BC041604.1 

    18 DOTS entries:

    DT.91757184  DT.415569  DT.97807183  DT.100818452  DT.97786331  DT.91757174  DT.95091232  DT.100818449 
    DT.86851661  DT.121380245  DT.206970  DT.121380198  DT.95301026  DT.121380200  DT.91757183  DT.92334622 
    DT.95120706  DT.95201978 

    Selected AceView cDNA sequences (see all 272):

    AF286041 CR601047 BC012796 AI479639 AA411584 AI245429 BG152670 CA312500 
    BX643269 AI200255 AI371485 AI582786 CR600921 AI874196 BQ574978 CA450276 
    AA411456 AA236502 AA301989 AI817704 AA234381 CA502980 BF512176 BC041604 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42SE1 expression in normal human tissues (normalized intensities)      CDC42SE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTCTGC
    CDC42SE1 Expression
    About this image


    CDC42SE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Bone marrow-derived hematopoietic stem cells (family)
             neutrophils   
    CDC42SE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42SE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22065

    UniProtKB/Swiss-Prot: C42S1_HUMAN, Q9NRR8
    Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes, dendritic and whole blood cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42SE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDC42SE1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42se11 , 5 CDC42 small effector 11, 5 91.56(n)1
    98.73(a)1
      3 (40.74 cM)5
    579121  NM_001038708.31  NP_001033797.11 
     952287325 
    chicken
    (Gallus gallus)
    Aves CDC42SE11 CDC42 small effector 1 76.07(n)
    84.62(a)
      100857323  XM_004948349.1  XP_004948406.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42SE16
    CDC42 small effector 1
    82(a)
    1 ↔ 1
    AAWZ02040816(552-668)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdc42se11 cdc42 small effector 1 75.88(n)
    84.21(a)
      595003  NM_001030444.1  NP_001025615.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa55c042 wufa55c04 76.71(n)   337314  AY423037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spec26
    Spec2
    33(a)
    1 → many
    3R(1442368-1449803)


    ENSEMBL Gene Tree for CDC42SE1 (if available)
    TreeFam Gene Tree for CDC42SE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC42SE1 gene
    CDC42SE22  
    1 SIMAP similar gene for CDC42SE1 using alignment to 1 protein entry:     C42S1_HUMAN:
    CDC42SE2

    CDC42SE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42SE1 (see all 100)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801024961,2
    F--151024516(+) GGCTCG/AGGCTT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs1127925741,2
    C,F--151024529(+) GATGAA/C/GTAAGA 4 -- ut311CSA 1
    rs741250591,2
    C,F--151024535(+) TAAGAT/CGATGA 2 -- ut313Minor allele frequency- C:0.09WA CSA 122
    rs1124631021,2
    F--151024654(+) AGAGAC/TATTTT 2 -- ut311Minor allele frequency- T:0.50CSA 2
    rs108884021,2
    C,F,H--151024688(+) CAGGGG/TTGCTG 2 -- ut31 ese313Minor allele frequency- T:0.05NS NA WA CSA 349
    rs1128175431,2
    C--151024792(+) TGTTCTAGA/-  
            
    TAGAG
    2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1862317891,2
    --151024885(+) CTCAAC/TGATCA 2 -- ut310--------
    rs121358751,2
    C,H--151024942(+) GGTTTC/TTTTCC 2 -- ut316Minor allele frequency- T:0.00NS EA NA 416
    rs1395957531,2
    C--151024959(+) CTCTTC/TCTCCT 2 -- ut310--------
    rs1906204901,2
    --151025175(+) AAAAGC/GAAAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CDC42SE1 (151023447 - 151042801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDC42SE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522840CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC42SE1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC42SE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for CDC42SE1:    About MalaCards
    scarlet fever    schistosomiasis

    1 disease from the University of Copenhagen DISEASES database for CDC42SE1:
    Scarlet fever

    CDC42SE1 for disorders           About GeneDecksing


    Export disorders for CDC42SE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42SE1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CDC42SE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SPECs, small binding proteins for Cdc42. (PubMed id 10816584)1, 2, 3 Pirone D.M.... Burbelo P.D. (J. Biol. Chem. 2000)
    2. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. (PubMed id 15840583)1, 2 Ching K.H.... Burbelo P.D. (J. Biol. Chem. 2005)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins. (PubMed id 18541383)1 Schnack C....Gillardon F. (Neuroscience 2008)
    10. Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis. (PubMed id 17045588)2 Ching K.H.... Burbelo P.D. (Exp. Cell Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56882 HGNC: 17719 AceView: CDC42SE1 Ensembl:ENSG00000197622 euGenes: HUgn56882
    ECgene: CDC42SE1 H-InvDB: CDC42SE1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC42SE1 Pharmacogenomics, SNPs, Pathways

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