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Aliases for CDC42EP5 Gene

Aliases for CDC42EP5 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 5 2 3
  • Binder Of Rho GTPases 3 3 4
  • Borg3 3 4
  • CEP5 3 4
  • Cdc42 Effector Protein 5 3

External Ids for CDC42EP5 Gene

Summaries for CDC42EP5 Gene

Entrez Gene Summary for CDC42EP5 Gene

  • Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

GeneCards Summary for CDC42EP5 Gene

CDC42EP5 (CDC42 Effector Protein (Rho GTPase Binding) 5) is a Protein Coding gene. Diseases associated with CDC42EP5 include quadriplegia. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP1.

UniProtKB/Swiss-Prot for CDC42EP5 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP5 Gene

Genomics for CDC42EP5 Gene

Genomic Location for CDC42EP5 Gene

Start:
54,465,025 bp from pter
End:
54,473,290 bp from pter
Size:
8,266 bases
Orientation:
Minus strand

Genomic View for CDC42EP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP5 Gene

Regulatory Elements for CDC42EP5 Gene

Proteins for CDC42EP5 Gene

  • Protein details for CDC42EP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZY7-BORG3_HUMAN
    Recommended name:
    Cdc42 effector protein 5
    Protein Accession:
    Q6NZY7
    Secondary Accessions:
    • B0VJZ2
    • Q8TB51

    Protein attributes for CDC42EP5 Gene

    Size:
    148 amino acids
    Molecular mass:
    15207 Da
    Quaternary structure:
    • Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP5 Gene

Proteomics data for CDC42EP5 Gene at MOPED

Post-translational modifications for CDC42EP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC42EP5 Gene

Domains for CDC42EP5 Gene

Protein Domains for CDC42EP5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BORG3_HUMAN
Domain:
  • The CRIB domain mediates interaction with CDC42.:
    • Q6NZY7
  • Contains 1 CRIB domain.:
    • Q6NZY7
Family:
  • Belongs to the BORG/CEP family.:
    • Q6NZY7
genes like me logo Genes that share domains with CDC42EP5: view

No data available for Gene Families for CDC42EP5 Gene

Function for CDC42EP5 Gene

Molecular function for CDC42EP5 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

Gene Ontology (GO) - Molecular Function for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017049 GTP-Rho binding IPI 11035016
genes like me logo Genes that share ontologies with CDC42EP5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDC42EP5 Gene

Localization for CDC42EP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP5 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42EP5 Gene COMPARTMENTS Subcellular localization image for CDC42EP5 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11035016
GO:0005856 cytoskeleton IBA --
GO:0005886 plasma membrane IBA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP5: view

Pathways for CDC42EP5 Gene

genes like me logo Genes that share pathways with CDC42EP5: view

Pathways by source for CDC42EP5 Gene

2 Qiagen pathways for CDC42EP5 Gene

Interacting Proteins for CDC42EP5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301200%0d%0a9606.ENSP00000314458%0d%0a9606.ENSP00000381992%0d%0a
Selected Interacting proteins: ENSP00000301200 Q6NZY7-BORG3_HUMAN for CDC42EP5 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade IEA --
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IDA 11035016
GO:0030838 positive regulation of actin filament polymerization IDA 11035016
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP5: view

Compounds for CDC42EP5 Gene

(1) HMDB Compounds for CDC42EP5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CDC42EP5: view

Transcripts for CDC42EP5 Gene

mRNA/cDNA for CDC42EP5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC42EP5 Gene

CDC42 effector protein (Rho GTPase binding) 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP5 Gene

No ASD Table

Relevant External Links for CDC42EP5 Gene

GeneLoc Exon Structure for
CDC42EP5
ECgene alternative splicing isoforms for
CDC42EP5

Expression for CDC42EP5 Gene

mRNA expression in normal human tissues for CDC42EP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42EP5 Gene

This gene is overexpressed in Colon - Transverse (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42EP5 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP5 Gene Hs.415791

genes like me logo Genes that share expressions with CDC42EP5: view

Orthologs for CDC42EP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42EP5 36
  • 99.55 (n)
  • 100 (a)
CDC42EP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42EP5 36
  • 91.22 (n)
  • 86.49 (a)
CDC42EP5 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42EP5 36
  • 87.16 (n)
  • 83.11 (a)
CDC42EP5 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42ep5 36
  • 78.83 (n)
  • 80.41 (a)
Cdc42ep5 16
Cdc42ep5 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42ep5 36
  • 73.87 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia CDC42EP5 37
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdc42ep1b 37
  • 21 (a)
OneToOne
Species with no ortholog for CDC42EP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP5 Gene

ENSEMBL:
Gene Tree for CDC42EP5 (if available)
TreeFam:
Gene Tree for CDC42EP5 (if available)

Paralogs for CDC42EP5 Gene

Paralogs for CDC42EP5 Gene

Selected SIMAP similar genes for CDC42EP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42EP5: view

Variants for CDC42EP5 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2287822 -- 54,471,384(-) CGCAG(C/T)TCCCA intron-variant
rs2287823 -- 54,471,189(-) CTCCC(C/T)GGGCT intron-variant
rs7245610 -- 54,474,896(+) GAAAA(A/C)CCTAT upstream-variant-2KB
rs7245711 -- 54,474,816(+) GGAAC(A/G)TACCT upstream-variant-2KB
rs7246643 -- 54,466,444(+) gtctc(A/T)ataaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP5 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv912413 CNV Loss 21882294
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073

Relevant External Links for CDC42EP5 Gene

HapMap Linkage Disequilibrium report
CDC42EP5

Disorders for CDC42EP5 Gene

(1) MalaCards Diseases for CDC42EP5 Gene

Search for CDC42EP5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CDC42EP5 Gene

Relevant External Links for CDC42EP5

Genetic Association Database (GAD)
CDC42EP5
genes like me logo Genes that share disorders with CDC42EP5: view

No data available for UniProtKB/Swiss-Prot for CDC42EP5 Gene

Publications for CDC42EP5 Gene

  1. Borg proteins control septin organization and are negatively regulated by Cdc42. (PMID: 11584266) Joberty G. … Macara I.G. (Nat. Cell Biol. 2001) 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. [Screening for lymphatic metastasis-associated genes in mouse hepatocarcinoma cell lines Hca-F and Hca-P using gene chip]. (PMID: 16004799) Song B. … Hou L. (Ai Zheng 2005) 23

Products for CDC42EP5 Gene

Sources for CDC42EP5 Gene

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