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Aliases for CDC42EP5 Gene

Aliases for CDC42EP5 Gene

  • CDC42 Effector Protein 5 2 3 5
  • Binder Of Rho GTPases 3 2 3 4
  • CDC42 Effector Protein (Rho GTPase Binding) 5 2 3
  • Borg3 3 4
  • CEP5 3 4

External Ids for CDC42EP5 Gene

Previous GeneCards Identifiers for CDC42EP5 Gene

  • GC19M055400
  • GC19M059652
  • GC19M059668
  • GC19M054976
  • GC19M051301

Summaries for CDC42EP5 Gene

Entrez Gene Summary for CDC42EP5 Gene

  • Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

GeneCards Summary for CDC42EP5 Gene

CDC42EP5 (CDC42 Effector Protein 5) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. Gene Ontology (GO) annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP1.

UniProtKB/Swiss-Prot for CDC42EP5 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

Additional gene information for CDC42EP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP5 Gene

Genomics for CDC42EP5 Gene

GeneHancer (GH) Regulatory Elements for CDC42EP5 Gene

Promoters and enhancers for CDC42EP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054459 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.2 +6.3 6267 14.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 POLR2B ZNF207 LENG9 CDC42EP5 LENG8-AS1 LENG8 ENSG00000267838 ENSG00000235681 CNOT3 TPM3P6 TTYH1 PRPF31
GH19I053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +604.4 604376 9.8 HDGF FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC30A9 MYADM LOC105372457 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6
GH19I055278 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.8 -807.1 -807115 2.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF213 HSPBP1 BRSK1 LENG8-AS1 LENG8 ENSG00000235681 U2AF2 ENSG00000267523 SSC5D ZNF581 CDC42EP5
GH19I055405 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.9 -934.1 -934136 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 UBE2S U2AF2 ZNF628 LENG8 ENSG00000267523 ZNF581 LENG8-AS1 RPL28 ENSG00000235681 ENSG00000267096
GH19I055062 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -589.6 -589589 1.7 HDGF PKNOX1 ATF1 ARNT SIN3A DMAP1 BRCA1 ZNF48 GTF3C2 GLIS2 RDH13 LENG8 ENSG00000235681 LENG8-AS1 CNOT3 U2AF2 ENSG00000267523 ZNF581 CDC42EP5 RPL28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDC42EP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDC42EP5 gene promoter:

Genomic Locations for CDC42EP5 Gene

Genomic Locations for CDC42EP5 Gene
chr19:54,465,025-54,473,290
(GRCh38/hg38)
Size:
8,266 bases
Orientation:
Minus strand
chr19:54,976,210-54,984,422
(GRCh37/hg19)

Genomic View for CDC42EP5 Gene

Genes around CDC42EP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42EP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42EP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP5 Gene

Proteins for CDC42EP5 Gene

  • Protein details for CDC42EP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZY7-BORG3_HUMAN
    Recommended name:
    Cdc42 effector protein 5
    Protein Accession:
    Q6NZY7
    Secondary Accessions:
    • B0VJZ2
    • Q8TB51

    Protein attributes for CDC42EP5 Gene

    Size:
    148 amino acids
    Molecular mass:
    15207 Da
    Quaternary structure:
    • Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP5 Gene

Post-translational modifications for CDC42EP5 Gene

No Post-translational modifications

Other Protein References for CDC42EP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC42EP5 Gene

Domains & Families for CDC42EP5 Gene

Gene Families for CDC42EP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDC42EP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC42EP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NZY7

UniProtKB/Swiss-Prot:

BORG3_HUMAN :
  • The CRIB domain mediates interaction with CDC42.
  • Belongs to the BORG/CEP family.
Domain:
  • The CRIB domain mediates interaction with CDC42.
Family:
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP5: view

Function for CDC42EP5 Gene

Molecular function for CDC42EP5 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

Phenotypes From GWAS Catalog for CDC42EP5 Gene

Gene Ontology (GO) - Molecular Function for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017049 GTP-Rho binding IPI 11035016
genes like me logo Genes that share ontologies with CDC42EP5: view
genes like me logo Genes that share phenotypes with CDC42EP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC42EP5 Gene

Localization for CDC42EP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP5 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC42EP5 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 11035016
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IBA,IEA --
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with CDC42EP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDC42EP5 Gene

Pathways & Interactions for CDC42EP5 Gene

genes like me logo Genes that share pathways with CDC42EP5: view

Pathways by source for CDC42EP5 Gene

2 Qiagen pathways for CDC42EP5 Gene

Gene Ontology (GO) - Biological Process for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade IEA --
GO:0007266 Rho protein signal transduction IEA,IBA --
GO:0008360 regulation of cell shape IEA,IDA 11035016
GO:0030838 positive regulation of actin filament polymerization IDA 11035016
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP5: view

No data available for SIGNOR curated interactions for CDC42EP5 Gene

Drugs & Compounds for CDC42EP5 Gene

(1) Drugs for CDC42EP5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CDC42EP5: view

Transcripts for CDC42EP5 Gene

mRNA/cDNA for CDC42EP5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC42EP5 Gene

CDC42 effector protein (Rho GTPase binding) 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP5 Gene

No ASD Table

Relevant External Links for CDC42EP5 Gene

GeneLoc Exon Structure for
CDC42EP5
ECgene alternative splicing isoforms for
CDC42EP5

Expression for CDC42EP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC42EP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42EP5 Gene

This gene is overexpressed in Colon - Transverse (x8.3).

Protein differential expression in normal tissues from HIPED for CDC42EP5 Gene

This gene is overexpressed in Islet of Langerhans (26.5), Fetal ovary (17.4), Prostate (14.1), and Placenta (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC42EP5 Gene



Protein tissue co-expression partners for CDC42EP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC42EP5 Gene:

CDC42EP5

SOURCE GeneReport for Unigene cluster for CDC42EP5 Gene:

Hs.415791

Evidence on tissue expression from TISSUES for CDC42EP5 Gene

  • Pancreas(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with CDC42EP5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC42EP5 Gene

Orthologs for CDC42EP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42EP5 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia CDC42EP5 33 34
  • 91.22 (n)
dog
(Canis familiaris)
Mammalia CDC42EP5 33 34
  • 87.16 (n)
mouse
(Mus musculus)
Mammalia Cdc42ep5 33 16 34
  • 78.83 (n)
rat
(Rattus norvegicus)
Mammalia Cdc42ep5 33
  • 73.87 (n)
lizard
(Anolis carolinensis)
Reptilia CDC42EP5 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdc42ep1b 34
  • 21 (a)
OneToOne
Species where no ortholog for CDC42EP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP5 Gene

ENSEMBL:
Gene Tree for CDC42EP5 (if available)
TreeFam:
Gene Tree for CDC42EP5 (if available)

Paralogs for CDC42EP5 Gene

Paralogs for CDC42EP5 Gene

(2) SIMAP similar genes for CDC42EP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42EP5: view

Variants for CDC42EP5 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000015318 -- 54,465,694(-) G/A intron_variant
rs1000023329 -- 54,469,598(-) T/G intron_variant
rs1000027697 -- 54,474,270(-) G/A upstream_transcript_variant
rs1000246736 -- 54,471,323(-) G/A intron_variant
rs1000564431 -- 54,474,955(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP5 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
nsv1148744 OTHER inversion 26484159
nsv833878 CNV loss 17160897

Variation tolerance for CDC42EP5 Gene

Gene Damage Index Score: 3.37; 53.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDC42EP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC42EP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42EP5 Gene

Disorders for CDC42EP5 Gene

Additional Disease Information for CDC42EP5

No disorders were found for CDC42EP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC42EP5 Gene

Publications for CDC42EP5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Borg proteins control septin organization and are negatively regulated by Cdc42. (PMID: 11584266) Joberty G … Macara IG (Nature cell biology 2001) 3 22 58
  3. The Borg family of Cdc42 effector proteins Cdc42EP1-5. (PMID: 27913681) Farrugia AJ … Calvo F (Biochemical Society transactions 2016) 3 58
  4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar FJ … Moffat J (Molecular systems biology 2013) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for CDC42EP5 Gene

Sources for CDC42EP5 Gene

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