Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC42EP5 Gene

Aliases for CDC42EP5 Gene

  • CDC42 Effector Protein 5 2 3
  • CDC42 Effector Protein (Rho GTPase Binding) 5 2 3 5
  • Binder Of Rho GTPases 3 2 3 4
  • Borg3 3 4
  • CEP5 3 4

External Ids for CDC42EP5 Gene

Previous GeneCards Identifiers for CDC42EP5 Gene

  • GC19M055400
  • GC19M059652
  • GC19M059668
  • GC19M054976
  • GC19M051301

Summaries for CDC42EP5 Gene

Entrez Gene Summary for CDC42EP5 Gene

  • Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

GeneCards Summary for CDC42EP5 Gene

CDC42EP5 (CDC42 Effector Protein 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP1.

UniProtKB/Swiss-Prot for CDC42EP5 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP5 Gene

Genomics for CDC42EP5 Gene

Regulatory Elements for CDC42EP5 Gene

Promoters for CDC42EP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC42EP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC42EP5 Gene

Chromosome:
19
Start:
54,465,025 bp from pter
End:
54,473,290 bp from pter
Size:
8,266 bases
Orientation:
Minus strand

Genomic View for CDC42EP5 Gene

Genes around CDC42EP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42EP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42EP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP5 Gene

Proteins for CDC42EP5 Gene

  • Protein details for CDC42EP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZY7-BORG3_HUMAN
    Recommended name:
    Cdc42 effector protein 5
    Protein Accession:
    Q6NZY7
    Secondary Accessions:
    • B0VJZ2
    • Q8TB51

    Protein attributes for CDC42EP5 Gene

    Size:
    148 amino acids
    Molecular mass:
    15207 Da
    Quaternary structure:
    • Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP5 Gene

Proteomics data for CDC42EP5 Gene at MOPED

Post-translational modifications for CDC42EP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDC42EP5 Gene

Domains & Families for CDC42EP5 Gene

Gene Families for CDC42EP5 Gene

Protein Domains for CDC42EP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC42EP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NZY7

UniProtKB/Swiss-Prot:

BORG3_HUMAN :
  • The CRIB domain mediates interaction with CDC42.
  • Belongs to the BORG/CEP family.
Domain:
  • The CRIB domain mediates interaction with CDC42.
  • Contains 1 CRIB domain.
Family:
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP5: view

Function for CDC42EP5 Gene

Molecular function for CDC42EP5 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).

Gene Ontology (GO) - Molecular Function for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with CDC42EP5: view
genes like me logo Genes that share phenotypes with CDC42EP5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC42EP5 Gene

Localization for CDC42EP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP5 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42EP5 Gene COMPARTMENTS Subcellular localization image for CDC42EP5 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CDC42EP5 Gene

Pathways & Interactions for CDC42EP5 Gene

genes like me logo Genes that share pathways with CDC42EP5: view

Pathways by source for CDC42EP5 Gene

2 Qiagen pathways for CDC42EP5 Gene

Interacting Proteins for CDC42EP5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301200%0d%0a9606.ENSP00000314458%0d%0a9606.ENSP00000381992%0d%0a
Selected Interacting proteins: Q6NZY7-BORG3_HUMAN ENSP00000301200 for CDC42EP5 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CDC42EP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IEA,IBA --
genes like me logo Genes that share ontologies with CDC42EP5: view

No data available for SIGNOR curated interactions for CDC42EP5 Gene

Drugs & Compounds for CDC42EP5 Gene

(1) Drugs for CDC42EP5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CDC42EP5: view

Transcripts for CDC42EP5 Gene

mRNA/cDNA for CDC42EP5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC42EP5 Gene

CDC42 effector protein (Rho GTPase binding) 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP5 Gene

No ASD Table

Relevant External Links for CDC42EP5 Gene

GeneLoc Exon Structure for
CDC42EP5
ECgene alternative splicing isoforms for
CDC42EP5

Expression for CDC42EP5 Gene

mRNA expression in normal human tissues for CDC42EP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42EP5 Gene

This gene is overexpressed in Colon - Transverse (x8.3).

Protein differential expression in normal tissues from HIPED for CDC42EP5 Gene

This gene is overexpressed in Islet of Langerhans (26.5), Fetal ovary (17.4), Prostate (14.1), and Placenta (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42EP5 Gene



SOURCE GeneReport for Unigene cluster for CDC42EP5 Gene Hs.415791

genes like me logo Genes that share expression patterns with CDC42EP5: view

Protein tissue co-expression partners for CDC42EP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDC42EP5 Gene

Orthologs for CDC42EP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42EP5 35
  • 99.55 (n)
  • 100 (a)
CDC42EP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42EP5 36
  • 82 (a)
OneToOne
CDC42EP5 35
  • 91.22 (n)
  • 86.49 (a)
dog
(Canis familiaris)
Mammalia CDC42EP5 35
  • 87.16 (n)
  • 83.11 (a)
CDC42EP5 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42ep5 16
Cdc42ep5 36
  • 77 (a)
OneToOne
Cdc42ep5 35
  • 78.83 (n)
  • 80.41 (a)
rat
(Rattus norvegicus)
Mammalia Cdc42ep5 35
  • 73.87 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia CDC42EP5 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdc42ep1b 36
  • 21 (a)
OneToOne
Species with no ortholog for CDC42EP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP5 Gene

ENSEMBL:
Gene Tree for CDC42EP5 (if available)
TreeFam:
Gene Tree for CDC42EP5 (if available)

Paralogs for CDC42EP5 Gene

Paralogs for CDC42EP5 Gene

(2) SIMAP similar genes for CDC42EP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42EP5: view

Variants for CDC42EP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP5 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv912413 CNV Loss 21882294
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073

Variation tolerance for CDC42EP5 Gene

Gene Damage Index Score: 3.37; 53.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC42EP5 Gene

HapMap Linkage Disequilibrium report
CDC42EP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CDC42EP5 Gene

Disorders for CDC42EP5 Gene

Relevant External Links for CDC42EP5

Genetic Association Database (GAD)
CDC42EP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC42EP5

No disorders were found for CDC42EP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC42EP5 Gene

Publications for CDC42EP5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Borg proteins control septin organization and are negatively regulated by Cdc42. (PMID: 11584266) Joberty G. … Macara I.G. (Nat. Cell Biol. 2001) 3 23
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. [Screening for lymphatic metastasis-associated genes in mouse hepatocarcinoma cell lines Hca-F and Hca-P using gene chip]. (PMID: 16004799) Song B. … Hou L. (Ai Zheng 2005) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDC42EP5 Gene

Sources for CDC42EP5 Gene

Back to Top

Content