Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC42EP4 Gene

Aliases for CDC42EP4 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 4 2 3
  • Binder Of Rho GTPases 4 2 3 4
  • BORG4 3 4 6
  • Cdc42 Effector Protein 4 2 3
  • CEP4 3 4
  • KAIA1777 3

External Ids for CDC42EP4 Gene

Previous GeneCards Identifiers for CDC42EP4 Gene

  • GC17P071218
  • GC17M074320
  • GC17M071744
  • GC17M071876
  • GC17M068791
  • GC17M071279
  • GC17M066689

Summaries for CDC42EP4 Gene

Entrez Gene Summary for CDC42EP4 Gene

  • The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42EP4 Gene

CDC42EP4 (CDC42 Effector Protein (Rho GTPase Binding) 4) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP1.

UniProtKB/Swiss-Prot for CDC42EP4 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts

Gene Wiki entry for CDC42EP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP4 Gene

Genomics for CDC42EP4 Gene

Regulatory Elements for CDC42EP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42EP4 Gene

73,283,624 bp from pter
73,312,175 bp from pter
28,552 bases
Minus strand

Genomic View for CDC42EP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP4 Gene

Proteins for CDC42EP4 Gene

  • Protein details for CDC42EP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cdc42 effector protein 4
    Protein Accession:
    Secondary Accessions:
    • B3KUS7
    • O95828
    • Q96FT3

    Protein attributes for CDC42EP4 Gene

    356 amino acids
    Molecular mass:
    37980 Da
    Quaternary structure:
    • Interacts with CDC42 and RHOQ, in a GTP-dependent manner.

    Alternative splice isoforms for CDC42EP4 Gene


neXtProt entry for CDC42EP4 Gene

Proteomics data for CDC42EP4 Gene at MOPED

Post-translational modifications for CDC42EP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP4 Gene

Antibody Products

No data available for DME Specific Peptides for CDC42EP4 Gene

Domains for CDC42EP4 Gene

Protein Domains for CDC42EP4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9H3Q1
  • Contains 1 CRIB domain.
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP4: view

No data available for Gene Families for CDC42EP4 Gene

Function for CDC42EP4 Gene

Molecular function for CDC42EP4 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts

Gene Ontology (GO) - Molecular Function for CDC42EP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017049 GTP-Rho binding NAS 11035016
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CDC42EP4: view

Phenotypes for CDC42EP4 Gene

GenomeRNAi human phenotypes for CDC42EP4:
genes like me logo Genes that share phenotypes with CDC42EP4: view

Animal Model Products

CRISPR Products

miRNA for CDC42EP4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42EP4 Gene

Localization for CDC42EP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP4 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for CDC42EP4 Gene COMPARTMENTS Subcellular localization image for CDC42EP4 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42EP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with CDC42EP4: view

Pathways for CDC42EP4 Gene

genes like me logo Genes that share pathways with CDC42EP4: view

Pathways by source for CDC42EP4 Gene

2 Qiagen pathways for CDC42EP4 Gene

Gene Ontology (GO) - Biological Process for CDC42EP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IDA 11035016
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP4: view

Compounds for CDC42EP4 Gene

(1) HMDB Compounds for CDC42EP4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with CDC42EP4: view

Transcripts for CDC42EP4 Gene

Unigene Clusters for CDC42EP4 Gene

CDC42 effector protein (Rho GTPase binding) 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42EP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - -
SP6: - - -
SP7: - -

Relevant External Links for CDC42EP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC42EP4 Gene

mRNA expression in normal human tissues for CDC42EP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDC42EP4 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP4 Gene Hs.3903

mRNA Expression by UniProt/SwissProt for CDC42EP4 Gene

Tissue specificity: Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues
genes like me logo Genes that share expressions with CDC42EP4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDC42EP4 Gene

Orthologs for CDC42EP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC42EP4 35
  • 99.06 (n)
  • 98.88 (a)
CDC42EP4 36
  • 99 (a)
(Bos Taurus)
Mammalia CDC42EP4 35
  • 81.76 (n)
  • 82.94 (a)
CDC42EP4 36
  • 77 (a)
(Canis familiaris)
Mammalia CDC42EP4 35
  • 84.39 (n)
  • 84.77 (a)
CDC42EP4 36
  • 80 (a)
(Mus musculus)
Mammalia Cdc42ep4 35
  • 82.37 (n)
  • 81.79 (a)
Cdc42ep4 16
Cdc42ep4 36
  • 77 (a)
(Monodelphis domestica)
Mammalia CDC42EP4 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CDC42EP4 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Cdc42ep4 35
  • 81.06 (n)
  • 81.16 (a)
(Gallus gallus)
Aves CDC42EP4 35
  • 69.14 (n)
  • 67.34 (a)
CDC42EP4 36
  • 63 (a)
(Anolis carolinensis)
Reptilia CDC42EP4 36
  • 62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16547 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42ep4 35
  • 62.19 (n)
  • 60.74 (a)
Str.10016 35
(Danio rerio)
Actinopterygii cdc42ep4a 35
  • 61.95 (n)
  • 60.61 (a)
cdc42ep4a 36
  • 39 (a)
cdc42ep4b 36
  • 46 (a)
wufb55a05 35
Species with no ortholog for CDC42EP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP4 Gene

Gene Tree for CDC42EP4 (if available)
Gene Tree for CDC42EP4 (if available)

Paralogs for CDC42EP4 Gene

Paralogs for CDC42EP4 Gene

Selected SIMAP similar genes for CDC42EP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CDC42EP4: view

Variants for CDC42EP4 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs536 -- 73,283,717(+) GGATT(C/T)GAGGG utr-variant-3-prime
rs3841 -- 73,283,700(+) TGGAA(C/T)TGGCC utr-variant-3-prime
rs6905 -- 73,283,913(-) GAACC(A/T)ACCAC utr-variant-3-prime
rs12795 -- 73,284,583(-) TCTTC(A/G)AAATT utr-variant-3-prime
rs904387 -- 73,298,615(+) CACCC(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP4 Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897
nsv908735 CNV Loss 21882294
esv2672949 CNV Deletion 23128226
nsv112220 CNV Loss 16902084
nsv908736 CNV Gain 21882294
nsv112181 CNV Loss 16902084

Relevant External Links for CDC42EP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42EP4 Gene

Disorders for CDC42EP4 Gene

No disorders were found for CDC42EP4 Gene.

No data available for UniProtKB/Swiss-Prot for CDC42EP4 Gene

Publications for CDC42EP4 Gene

  1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PMID: 11035016) Hirsch D.S. … Burbelo P.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue. (PMID: 11185749) Osada N. … Hashimoto K. (J. Hum. Genet. 2000) 3 4 23
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CDC42EP4 Gene

Sources for CDC42EP4 Gene

Back to Top