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CDC42EP4 Gene

protein-coding   GIFtS: 54
GCID: GC17M071279

CDC42 Effector Protein (Rho GTPase Binding) 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC42 Effector Protein (Rho GTPase Binding) 41 2
Binder Of Rho GTPases 41 2 3
BORG42 3 5
Cdc42 Effector Protein 41 2
CEP42 3
KAIA17772

External Ids:    HGNC: 171471   Entrez Gene: 235802   Ensembl: ENSG000001796047   OMIM: 6054685   UniProtKB: Q9H3Q13   

Export aliases for CDC42EP4 gene to outside databases

Previous GC identifers: GC17P071218 GC17M074320 GC17M071744 GC17M071876 GC17M068791 GC17M066689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC42EP4 Gene:
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho
family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both
CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to
induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDC42EP4 Gene:
CDC42EP4 (CDC42 effector protein (Rho GTPase binding) 4) is a protein-coding gene. Diseases associated with CDC42EP4 include retinitis, and cerebritis. GO annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP5.

UniProtKB/Swiss-Prot: BORG4_HUMAN, Q9H3Q1
Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce
actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in
fibroblasts

Gene Wiki entry for CDC42EP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42EP4 gene promoter:
         POU3F1   Nkx2-5   NF-kappaB   GATA-1   Meis-1b   GATA-6   Meis-1a   Zic3   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC42EP4 promoter sequence
   Search Chromatin IP Primers for CDC42EP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42EP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24-q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q24-q25

CDC42EP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42EP4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M071279:  view genomic region     (about GC identifiers)

Start:
71,279,763 bp from pter      End:
71,308,314 bp from pter
Size:
28,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BORG4_HUMAN, Q9H3Q1 (See protein sequence)
Recommended Name: Cdc42 effector protein 4  
Size: 356 amino acids; 37980 Da
Subunit: Interacts with CDC42 and RHOQ, in a GTP-dependent manner (By similarity)
Secondary accessions: O95828 Q96FT3

Explore the universe of human proteins at neXtProt for CDC42EP4: NX_Q9H3Q1

Explore proteomics data for CDC42EP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC42EP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036253.2  
    ENSEMBL proteins: 
     ENSP00000338258   ENSP00000404270   ENSP00000464104   ENSP00000462231   ENSP00000463877  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry Q9H3Q1

    ProtoNet protein and cluster: Q9H3Q1

    UniProtKB/Swiss-Prot: BORG4_HUMAN, Q9H3Q1
    Similarity: Belongs to the BORG/CEP family
    Similarity: Contains 1 CRIB domain


    CDC42EP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BORG4_HUMAN, Q9H3Q1
    Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce
    actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in
    fibroblasts

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017049GTP-Rho binding NAS11035016
    GO:0044822poly(A) RNA binding IDA--
         
    CDC42EP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC42EP4:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC42EP4
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    miRNA
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    miRTarBase miRNAs that target CDC42EP4:
    hsa-mir-335-5p (MIRT017707), hsa-mir-941 (MIRT036563), hsa-mir-1229-3p (MIRT036315), hsa-mir-7-5p (MIRT025742), hsa-mir-193b-3p (MIRT016422)

    Block miRNA regulation of human, mouse, rat CDC42EP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42EP4 (see all 16):
    hsa-miR-2052 hsa-miR-3128 hsa-miR-875-3p hsa-miR-19b-2* hsa-miR-922 hsa-miR-409-3p hsa-miR-3133 hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC42EP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC42EP4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42EP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BORG4_HUMAN, Q9H3Q1: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    mitochondrion3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA--
    GO:0012505endomembrane system IEA--
    GO:0015629actin cytoskeleton IDA--
    GO:0015630microtubule cytoskeleton IDA--

    CDC42EP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC42EP4 About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Rho Family GTPases0.61
    2Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC42EP4
        RhoA Pathway
    Rho Family GTPases



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC42EP4
    Interactions:

        GeneGlobe Interaction Network for CDC42EP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CDC42EP4 (Q9H3Q12, 3 ENSP000003382584) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR6Q9NNW52, 3, ENSP000003788574MINT-66544 I2D: score=4 STRING: ENSP00000378857
    RHOQP170813, ENSP000002387384I2D: score=4 STRING: ENSP00000238738
    POLR3HQ9Y5353, ENSP000003473454I2D: score=1 STRING: ENSP00000347345
    CDC42P609533, ENSP000003144584I2D: score=4 STRING: ENSP00000314458
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007266Rho protein signal transduction IEA--
    GO:0008360regulation of cell shape IDA11035016
    GO:0031274positive regulation of pseudopodium assembly IDA11035016

    CDC42EP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC42EP4 (BORG4)

    1 HMDB Compound for CDC42EP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC42EP4 gene: 
    NM_012121.4  

    Unigene Cluster for CDC42EP4:

    CDC42 effector protein (Rho GTPase binding) 4
    Hs.3903  [show with all ESTs]
    Unigene Representative Sequence: BC002774
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335793(uc002jjn.3 uc002jjo.3 uc002jjp.1) ENST00000439510
    ENST00000581014 ENST00000580315 ENST00000579611 ENST00000581045 ENST00000582303
    ENST00000578516
    miRNA
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    Block miRNA regulation of human, mouse, rat CDC42EP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42EP4 (see all 16):
    hsa-miR-2052 hsa-miR-3128 hsa-miR-875-3p hsa-miR-19b-2* hsa-miR-922 hsa-miR-409-3p hsa-miR-3133 hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC42EP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC42EP4
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    OriGene qPCR primer pairs and template standards for CDC42EP4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC42EP4
      QuantiTect SYBR Green Assays in human, mouse, rat CDC42EP4
      QuantiFast Probe-based Assays in human, mouse, rat CDC42EP4

    Additional mRNA sequence: 

    AB042237.1 AF099664.1 AK027385.1 AK097835.1 AK312536.1 AL162074.1 BC002774.1 BC010451.1 

    10 DOTS entries:

    DT.92025596  DT.100786650  DT.100709605  DT.95127934  DT.102830260  DT.100786644  DT.102830259  DT.100713156 
    DT.100786646  DT.100786651 

    Selected AceView cDNA sequences (see all 471):

    BQ686366 BQ691938 BQ897029 BU145645 BQ687436 BQ953193 BU151441 BQ686716 
    BU146296 BQ688322 BQ890488 BQ689691 BU157928 BU146183 BU151515 BU157713 
    BE857334 BQ690700 BQ896997 BQ684792 AL133957 BQ690282 BQ685576 BQ686739 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8
    SP1:                    -     -     -     -                                             
    SP2:                    -     -     -     -     -                       -     -         
    SP3:                                            -                                       
    SP4:                    -     -     -     -     -                                       
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CDC42EP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42EP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTGTCAA
    CDC42EP4 Expression
    About this image


    CDC42EP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    CDC42EP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42EP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3903

    UniProtKB/Swiss-Prot: BORG4_HUMAN, Q9H3Q1
    Tissue specificity: Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic
    tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42EP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDC42EP4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42ep41 , 5 CDC42 effector protein (Rho GTPase binding) 41, 5 82.37(n)1
    81.79(a)1
      11 (79.22 cM)5
    566991  NM_020006.21  NP_064390.11 
     1137268505 
    chicken
    (Gallus gallus)
    Aves CDC42EP41 CDC42 effector protein (Rho GTPase binding) 4 69.14(n)
    67.34(a)
      771509  XM_004946245.1  XP_004946302.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42EP46
    CDC42 effector protein (Rho GTPase binding) 4
    62(a)
    1 ↔ 1
    2(96837454-96838479)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165472 Xenopus laevis transcribed sequence with weak similarity more 76.77(n)    48050839 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb55a052 Transcribed sequence with weak similarity to protein more 73.41(n)    BM184609.1 


    ENSEMBL Gene Tree for CDC42EP4 (if available)
    TreeFam Gene Tree for CDC42EP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC42EP4 gene
    CDC42EP52  CDC42EP12  
    2 SIMAP similar genes for CDC42EP4 using alignment to 6 protein entries:     BORG4_HUMAN (see all proteins):
    CDC42EP1    CDC42EP5

    CDC42EP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42EP4 (see all 779)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898511601,2
    --71279384(+) AAAACA/TAAACA 1 -- ds50010--------
    rs2013050031,2
    --71279399(+) AACAA-/CAAAAA 1 -- ds50010--------
    rs782599411,2
    C--71279400(+) AACAAC/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1824143861,2
    --71279441(+) TCCCCA/CACAAA 1 -- ds50010--------
    rs1455091341,2
    --71279638(+) AAGGGC/TGGGTC 1 -- ds50010--------
    rs46418121,2
    C,F,A,H--71279681(-) GTCCAG/AGGGGG 1 -- ds500114Minor allele frequency- A:0.49NS EA NA WA CSA 772
    rs1465156961,2
    --71279682(+) CCCCCG/TGGACA 1 -- ds50010--------
    rs341212961,2
    C--71279773(+) TTTTTT/-AATGT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs3719229521,2
    C--71279774(+) AGGGC-/TTTTTT 1 -- ut310--------
    rs38411,2
    C,F,H--71279839(+) TGGAAT/CTGGCC 1 -- ut31 ese314Minor allele frequency- C:0.45MN NA WA EA 700

    HapMap Linkage Disequilibrium report for CDC42EP4 (71279763 - 71308314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDC42EP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672949CNV Deletion23128226
    nsv112181CNV Loss16902084
    nsv908735CNV Loss21882294
    nsv833534CNV Loss17160897
    nsv112220CNV Loss16902084
    nsv908736CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605468    OMIM disorders: --

    2 diseases for CDC42EP4:    
    About MalaCards
    retinitis    cerebritis


    CDC42EP4 for disorders           About GeneDecksing


    Export disorders for CDC42EP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42EP4 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CDC42EP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PubMed id 11035016)1, 2, 3, 9 Hirsch D.S.... Burbelo P.D. (J. Biol. Chem. 2001)
    2. Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue. (PubMed id 11185749)1, 2, 9 Osada N.... Hashimoto K. (J. Hum. Genet. 2000)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PubMed id 10490598)1, 3 Joberty G.... Macara I.G. (Mol. Cell. Biol. 1999)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23580 HGNC: 17147 AceView: CDC42EP4 Ensembl:ENSG00000179604 euGenes: HUgn23580
    ECgene: CDC42EP4 H-InvDB: CDC42EP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC42EP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDC42EP4 gene:
    Search GeneIP for patents involving CDC42EP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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