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CDC42EP3 Gene

protein-coding   GIFtS: 57
GCID: GC02M037878

CDC42 Effector Protein (Rho GTPase Binding) 3

  Search for CDC42EP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC42 Effector Protein (Rho GTPase Binding) 31 2     UB12
BORG22 3 5     Cdc42 Effector Protein 32
CEP32 3 5     CRIB-Containing BORG2 Protein2
Binder Of Rho GTPases 22 3     MSE55-Related Protein2
MSE55-Related Cdc42-Binding Protein2 3     

External Ids:    HGNC: 169431   Entrez Gene: 106022   Ensembl: ENSG000001631717   OMIM: 6061335   UniProtKB: Q9UKI23   

Export aliases for CDC42EP3 gene to outside databases

Previous GC identifers: GC02M037836 GC02M038019 GC02M037845 GC02M037782 GC02M037610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC42EP3 Gene:
This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a
CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42
function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes,
including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for CDC42EP3 Gene:
CDC42EP3 (CDC42 effector protein (Rho GTPase binding) 3) is a protein-coding gene. GO annotations related to this gene include cytoskeletal regulatory protein binding. An important paralog of this gene is CDC42EP2.

UniProtKB/Swiss-Prot: BORG2_HUMAN, Q9UKI2
Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce
actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts

Gene Wiki entry for CDC42EP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42EP3 gene promoter:
         Pax-5   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   NF-kappaB   NF-kappaB2   SEF-1 (1)   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC42EP3 promoter sequence
   Search Chromatin IP Primers for CDC42EP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42EP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p21

CDC42EP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42EP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M037878:  view genomic region     (about GC identifiers)

Start:
37,869,032 bp from pter      End:
37,965,611 bp from pter
Size:
96,580 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BORG2_HUMAN, Q9UKI2 (See protein sequence)
Recommended Name: Cdc42 effector protein 3  
Size: 254 amino acids; 27678 Da
Subunit: Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7
Secondary accessions: B2R8S0 O95353 Q9UQJ0

Explore the universe of human proteins at neXtProt for CDC42EP3: NX_Q9UKI2

Explore proteomics data for CDC42EP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC42EP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257365.1  NP_001257366.1  NP_001257367.1  NP_006440.2  

    ENSEMBL proteins: 
     ENSP00000295324   ENSP00000403298   ENSP00000398062   ENSP00000409147  

    CDC42EP3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDC42EP3

     
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    Search eBioscience for ELISAs for CDC42EP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000095 CRIB_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKI2

    ProtoNet protein and cluster: Q9UKI2

    UniProtKB/Swiss-Prot: BORG2_HUMAN, Q9UKI2
    Similarity: Belongs to the BORG/CEP family
    Similarity: Contains 1 CRIB domain


    Find genes that share domains with CDC42EP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BORG2_HUMAN, Q9UKI2
    Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce
    actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005519cytoskeletal regulatory protein binding TAS11035016
         
    Find genes that share ontologies with CDC42EP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC42EP3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC42EP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC42EP3

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC42EP3

    miRNA
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    miRTarBase miRNAs that target CDC42EP3:
    hsa-mir-124-3p (MIRT022352), hsa-mir-122-5p (MIRT023231)

    Block miRNA regulation of human, mouse, rat CDC42EP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42EP3 (see all 39):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-345 hsa-miR-379* hsa-miR-429 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCDC42EP3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC42EP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42EP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BORG2_HUMAN, Q9UKI2: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0012505endomembrane system IEA--
    GO:0015629actin cytoskeleton IDA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with CDC42EP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC42EP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    RhoA Pathway0.35
    2ERK Signaling
    Rho Family GTPases0.61
    3G protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC42EP3
        RhoA Pathway
    CDC42 Pathway
    Rho Family GTPases

    1 GeneGo (Thomson Reuters) Pathway for CDC42EP3
        Cytoskeleton remodeling CDC42 in cellular processes


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC42EP3: 
              Cytoskeleton Regulators in human mouse rat
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC42EP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CDC42EP3 (Q9UKI22, 3 ENSP000002953244) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UMPSP111722, 3, ENSP000002326074MINT-63458 I2D: score=5 STRING: ENSP00000232607
    SEPT6Q141413, ENSP000003415244I2D: score=1 STRING: ENSP00000341524
    SEPT7Q161813, ENSP000003819924I2D: score=1 STRING: ENSP00000381992
    CDC42P609533, ENSP000003144584I2D: score=6 STRING: ENSP00000314458
    RHOQP170813, ENSP000002387384I2D: score=4 STRING: ENSP00000238738
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS11035016
    GO:0008360regulation of cell shape IEA--

    Find genes that share ontologies with CDC42EP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC42EP3 (BORG2)

    1 HMDB Compound for CDC42EP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC42EP3 gene (4 alternative transcripts): 
    NM_001270436.1  NM_001270437.1  NM_001270438.1  NM_006449.4  

    Unigene Cluster for CDC42EP3:

    CDC42 effector protein (Rho GTPase binding) 3
    Hs.369574  [show with all ESTs]
    Unigene Representative Sequence: NM_006449
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295324(uc002rqi.1) ENST00000457889 ENST00000453555 ENST00000422687
    ENST00000494083
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDC42EP3 (see all 39):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-345 hsa-miR-379* hsa-miR-429 hsa-miR-605 hsa-miR-200a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCDC42EP3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CDC42EP3 (NM_006449)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42EP3
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    OriGene qPCR primer pairs and template standards for CDC42EP3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC42EP3
      QuantiTect SYBR Green Assays in human, mouse, rat CDC42EP3
      QuantiFast Probe-based Assays in human, mouse, rat CDC42EP3

    Additional mRNA sequence: 

    AF094521.1 AF104857.1 AF164118.1 AK055915.1 AK128735.1 AK313483.1 AL136842.1 BC019270.1 
    BT007190.1 

    12 DOTS entries:

    DT.113817  DT.70102907  DT.100808730  DT.95098564  DT.100728249  DT.100803234  DT.100802916  DT.100837203 
    DT.121015207  DT.99993163  DT.91769573  DT.99976436 

    Selected AceView cDNA sequences (see all 370):

    AA373277 AA687855 AW157009 CD559026 CA413281 BI793294 AI537472 AA213816 
    AI871943 NM_006449 AA302333 BF002926 CB528603 CB150094 AI202478 AI289476 
    AA764942 AA602411 BI906659 BQ575341 AW954287 BC019270 BQ948025 AA831236 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
    SP1:              -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for CDC42EP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42EP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTAAGAC
    CDC42EP3 Expression
    About this image


    CDC42EP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Uterus (Reproductive System)
     
     Prostate (Endocrine System)
    CDC42EP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42EP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369574

    UniProtKB/Swiss-Prot: BORG2_HUMAN, Q9UKI2
    Tissue specificity: Highly expressed in the heart and weakly in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC42EP3: 
              Cytoskeleton Regulators in human mouse rat
              Leukemia in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat CDC42EP3
    QuantiFast Probe-based Assays in human, mouse, rat CDC42EP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42EP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDC42EP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42ep31 , 5 CDC42 effector protein (Rho GTPase binding) 31, 5 87.53(n)1
    92.52(a)1
      17 (50.30 cM)5
    2604091  NM_026514.21  NP_080790.11 
     793340255 
    chicken
    (Gallus gallus)
    Aves CDC42EP31 CDC42 effector protein (Rho GTPase binding) 3 73.17(n)
    78.09(a)
      428577  XM_004935413.1  XP_004935470.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42EP36
    CDC42 effector protein (Rho GTPase binding) 3
    74(a)
    1 ↔ 1
    1(232199318-232200088)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.122212 Transcribed sequence with moderate similarity to protein more 76.92(n)    BX707700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc21b022 wufc21b02 77.5(n)   324174  57051513 


    ENSEMBL Gene Tree for CDC42EP3 (if available)
    TreeFam Gene Tree for CDC42EP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CDC42EP3 gene
    CDC42EP22  
    2 SIMAP similar genes for CDC42EP3 using alignment to 4 protein entries:     BORG2_HUMAN (see all proteins):
    CDC42EP1    CDC42EP2

    Find genes that share paralogs with CDC42EP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CDC42EP3
    PGOHUM00000234638


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42EP3 (see all 800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354662741,2
    C--37767977(+) AAAAA-/AT/T  
            
    CTTTG
    4 -- int11NA 2
    rs170211751,2
    C,F,H--37868687(+) CCACAA/CAACTG 4 -- ds50018Minor allele frequency- C:0.07NA NS EA WA 680
    rs1475430831,2
    --37868726(+) AAGCTC/TTTTTT 4 -- ds50010--------
    rs1866697361,2
    --37868768(+) GTGCAA/TATTTT 4 -- ds50010--------
    rs1911690391,2
    --37868769(+) TGCATA/GTTTTG 4 -- ds50010--------
    rs1847671401,2
    --37868830(+) ACTCAC/GCTTTG 4 -- ds50010--------
    rs1905355371,2
    --37868905(+) CTGCAC/TGATGG 4 -- ds50010--------
    rs38321041,2
    C--37869040(-) AAAAA-/ATCCGT 4 -- ut311Minor allele frequency- A:0.00CSA 2
    rs746193611,2
    --37869040(+) ACGGAT/ATTTTT 4 -- ut311Minor allele frequency- A:0.50NA 2
    rs568225111,2
    C--37869051(+) TTTTT-/T/TT  
            
    AACAG
    8 -- ut310--------

    HapMap Linkage Disequilibrium report for CDC42EP3 (37869032 - 37965611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDC42EP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873880CNV Loss21882294
    nsv508081CNV Loss20534489
    nsv833825CNV Gain17160897
    dgv1173e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606133    OMIM disorders: --


    Find genes that share disorders with CDC42EP3           About GenesLikeMe

    Genetic Association Database (GAD): CDC42EP3

    Export disorders for CDC42EP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42EP3 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CDC42EP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PubMed id 11035016)1, 2, 3, 9 Hirsch D.S.... Burbelo P.D. (J. Biol. Chem. 2001)
    2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Borg proteins control septin organization and are negatively regulated by Cdc42. (PubMed id 11584266)1, 2 Joberty G.... Macara I.G. (Nat. Cell Biol. 2001)
    9. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PubMed id 10490598)1, 2 Joberty G.... Macara I.G. (Mol. Cell. Biol. 1999)
    10. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. (PubMed id 9535835)1, 3 Alberts A.S....Treisman R. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10602 HGNC: 16943 AceView: CDC42EP3 Ensembl:ENSG00000163171 euGenes: HUgn10602
    ECgene: CDC42EP3 H-InvDB: CDC42EP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC42EP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC42EP3 gene:
    Search GeneIP for patents involving CDC42EP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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