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Aliases for CDC42EP3 Gene

Aliases for CDC42EP3 Gene

  • CDC42 Effector Protein 3 2 3
  • CDC42 Effector Protein (Rho GTPase Binding) 3 2 3 5
  • Binder Of Rho GTPases 2 2 3 4
  • MSE55-Related Cdc42-Binding Protein 3 4
  • BORG2 3 4
  • CEP3 3 4
  • CRIB-Containing BORG2 Protein 3
  • MSE55-Related Protein 3
  • UB1 3

External Ids for CDC42EP3 Gene

Previous GeneCards Identifiers for CDC42EP3 Gene

  • GC02M037836
  • GC02M038019
  • GC02M037845
  • GC02M037782
  • GC02M037878

Summaries for CDC42EP3 Gene

Entrez Gene Summary for CDC42EP3 Gene

  • This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for CDC42EP3 Gene

CDC42EP3 (CDC42 Effector Protein 3) is a Protein Coding gene. Among its related pathways are G-protein signaling RAC1 in cellular process and ERK Signaling. GO annotations related to this gene include GTP-Rho binding and cytoskeletal regulatory protein binding. An important paralog of this gene is CDC42EP2.

UniProtKB/Swiss-Prot for CDC42EP3 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.

Gene Wiki entry for CDC42EP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP3 Gene

Genomics for CDC42EP3 Gene

Regulatory Elements for CDC42EP3 Gene

Enhancers for CDC42EP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC42EP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC42EP3 Gene

37,641,882 bp from pter
37,738,468 bp from pter
96,587 bases
Minus strand

Genomic View for CDC42EP3 Gene

Genes around CDC42EP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42EP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42EP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP3 Gene

Proteins for CDC42EP3 Gene

  • Protein details for CDC42EP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cdc42 effector protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R8S0
    • O95353
    • Q9UQJ0

    Protein attributes for CDC42EP3 Gene

    254 amino acids
    Molecular mass:
    27678 Da
    Quaternary structure:
    • Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP3 Gene

Proteomics data for CDC42EP3 Gene at MOPED

Post-translational modifications for CDC42EP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP3 Gene

Antibody Products

No data available for DME Specific Peptides for CDC42EP3 Gene

Domains & Families for CDC42EP3 Gene

Gene Families for CDC42EP3 Gene

Protein Domains for CDC42EP3 Gene


Suggested Antigen Peptide Sequences for CDC42EP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRIB domain.
  • Belongs to the BORG/CEP family.
  • Contains 1 CRIB domain.
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP3: view

Function for CDC42EP3 Gene

Molecular function for CDC42EP3 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.

Gene Ontology (GO) - Molecular Function for CDC42EP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with CDC42EP3: view
genes like me logo Genes that share phenotypes with CDC42EP3: view

Animal Model Products

CRISPR Products

miRNA for CDC42EP3 Gene

miRTarBase miRNAs that target CDC42EP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42EP3 Gene

Localization for CDC42EP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP3 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for CDC42EP3 Gene COMPARTMENTS Subcellular localization image for CDC42EP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CDC42EP3 Gene

Pathways & Interactions for CDC42EP3 Gene

genes like me logo Genes that share pathways with CDC42EP3: view

Pathways by source for CDC42EP3 Gene

1 GeneGo (Thomson Reuters) pathway for CDC42EP3 Gene
3 Qiagen pathways for CDC42EP3 Gene

Gene Ontology (GO) - Biological Process for CDC42EP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 11035016
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IBA --
genes like me logo Genes that share ontologies with CDC42EP3: view

No data available for SIGNOR curated interactions for CDC42EP3 Gene

Drugs & Compounds for CDC42EP3 Gene

(1) Drugs for CDC42EP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CDC42EP3: view

Transcripts for CDC42EP3 Gene

Unigene Clusters for CDC42EP3 Gene

CDC42 effector protein (Rho GTPase binding) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: - -
SP2: -

Relevant External Links for CDC42EP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC42EP3 Gene

mRNA expression in normal human tissues for CDC42EP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42EP3 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for CDC42EP3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (45.5) and Bone marrow stromal cell (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42EP3 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP3 Gene Hs.369574

mRNA Expression by UniProt/SwissProt for CDC42EP3 Gene

Tissue specificity: Highly expressed in the heart and weakly in the brain.
genes like me logo Genes that share expression patterns with CDC42EP3: view

Protein tissue co-expression partners for CDC42EP3 Gene

Primer Products

Orthologs for CDC42EP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC42EP3 35
  • 89.24 (n)
  • 94.09 (a)
CDC42EP3 36
  • 94 (a)
(Canis familiaris)
Mammalia CDC42EP3 35
  • 88.67 (n)
  • 94.07 (a)
CDC42EP3 36
  • 94 (a)
(Mus musculus)
Mammalia Cdc42ep3 35
  • 87.53 (n)
  • 92.52 (a)
Cdc42ep3 16
Cdc42ep3 36
  • 93 (a)
(Pan troglodytes)
Mammalia CDC42EP3 35
  • 99.48 (n)
  • 100 (a)
CDC42EP3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdc42ep3 35
  • 87.8 (n)
  • 94.09 (a)
(Monodelphis domestica)
Mammalia CDC42EP3 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CDC42EP3 36
  • 75 (a)
(Gallus gallus)
Aves CDC42EP3 35
  • 73.17 (n)
  • 78.09 (a)
CDC42EP3 36
  • 77 (a)
(Anolis carolinensis)
Reptilia CDC42EP3 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42ep3 35
  • 68.12 (n)
  • 74.6 (a)
Str.12221 35
(Danio rerio)
Actinopterygii cdc42ep3 35
  • 64.83 (n)
  • 72.44 (a)
wufc21b02 35
cdc42ep3 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7243 36
  • 20 (a)
Species with no ortholog for CDC42EP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP3 Gene

Gene Tree for CDC42EP3 (if available)
Gene Tree for CDC42EP3 (if available)

Paralogs for CDC42EP3 Gene

Paralogs for CDC42EP3 Gene

(2) SIMAP similar genes for CDC42EP3 Gene using alignment to 4 proteins: Pseudogenes for CDC42EP3 Gene

genes like me logo Genes that share paralogs with CDC42EP3: view

Variants for CDC42EP3 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1860770 -- 37,670,533(-) CAGCC(C/T)AGGCT intron-variant
rs2041505 -- 37,672,960(-) TGTGC(C/G)TTTCC upstream-variant-2KB
rs2041506 -- 37,672,877(-) GACCC(A/G)GGGCA upstream-variant-2KB
rs2041507 -- 37,659,132(-) TTGGG(A/G)AAGAG intron-variant
rs2041508 -- 37,649,526(-) ATCCA(G/T)TCAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP3 Gene

Variant ID Type Subtype PubMed ID
dgv1173e1 CNV Complex 17122850
nsv833825 CNV Gain 17160897
nsv873880 CNV Loss 21882294
nsv508081 CNV Loss 20534489

Variation tolerance for CDC42EP3 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDC42EP3 Gene

Disorders for CDC42EP3 Gene

Relevant External Links for CDC42EP3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDC42EP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC42EP3 Gene

Publications for CDC42EP3 Gene

  1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PMID: 11035016) Hirsch D.S. … Burbelo P.D. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Human fertility protein PUMILIO2 interacts in vitro with testis mRNA encoding Cdc42 effector 3 (CEP3). (PMID: 17173092) Spik A. … Jaruzelska J. (Reprod Biol 2006) 3 23
  3. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. (PMID: 9535835) Alberts A.S. … Treisman R. (J. Biol. Chem. 1998) 2 3
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for CDC42EP3 Gene

Sources for CDC42EP3 Gene