Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC42EP3 Gene

Aliases for CDC42EP3 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 3 2 3
  • BORG2 3 4 6
  • CEP3 3 4 6
  • MSE55-Related Cdc42-Binding Protein 3 4
  • Binder Of Rho GTPases 2 3 4
  • CRIB-Containing BORG2 Protein 3
  • Cdc42 Effector Protein 3 3
  • MSE55-Related Protein 3
  • UB1 3

External Ids for CDC42EP3 Gene

Summaries for CDC42EP3 Gene

Entrez Gene Summary for CDC42EP3 Gene

  • This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for CDC42EP3 Gene

CDC42EP3 (CDC42 Effector Protein (Rho GTPase Binding) 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include cytoskeletal regulatory protein binding.

UniProtKB/Swiss-Prot for CDC42EP3 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.

Gene Wiki entry for CDC42EP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP3 Gene

Genomics for CDC42EP3 Gene

Genomic Location for CDC42EP3 Gene

Start:
37,641,882 bp from pter
End:
37,738,468 bp from pter
Size:
96,587 bases
Orientation:
Minus strand

Genomic View for CDC42EP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP3 Gene

Proteins for CDC42EP3 Gene

  • Protein details for CDC42EP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKI2-BORG2_HUMAN
    Recommended name:
    Cdc42 effector protein 3
    Protein Accession:
    Q9UKI2
    Secondary Accessions:
    • B2R8S0
    • O95353
    • Q9UQJ0

    Protein attributes for CDC42EP3 Gene

    Size:
    254 amino acids
    Molecular mass:
    27678 Da
    Quaternary structure:
    • Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP3 Gene

Proteomics data for CDC42EP3 Gene at MOPED

Post-translational modifications for CDC42EP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP3 Gene

No data available for DME Specific Peptides for CDC42EP3 Gene

Domains for CDC42EP3 Gene

Protein Domains for CDC42EP3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BORG2_HUMAN
Domain:
  • Contains 1 CRIB domain.:
    • Q9UKI2
Family:
  • Belongs to the BORG/CEP family.:
    • Q9UKI2
genes like me logo Genes that share domains with CDC42EP3: view

No data available for Gene Families for CDC42EP3 Gene

Function for CDC42EP3 Gene

Molecular function for CDC42EP3 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.

Gene Ontology (GO) - Molecular Function for CDC42EP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005519 cytoskeletal regulatory protein binding TAS 11035016
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with CDC42EP3: view

Phenotypes for CDC42EP3 Gene

GenomeRNAi human phenotypes for CDC42EP3:
genes like me logo Genes that share phenotypes with CDC42EP3: view

miRNA for CDC42EP3 Gene

miRTarBase miRNAs that target CDC42EP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42EP3 Gene

Localization for CDC42EP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP3 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42EP3 Gene COMPARTMENTS Subcellular localization image for CDC42EP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42EP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
GO:0012505 endomembrane system IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CDC42EP3: view

Pathways for CDC42EP3 Gene

genes like me logo Genes that share pathways with CDC42EP3: view

Pathways by source for CDC42EP3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDC42EP3 Gene
3 Qiagen pathways for CDC42EP3 Gene

Gene Ontology (GO) - Biological Process for CDC42EP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 11035016
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IBA --
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IBA --
genes like me logo Genes that share ontologies with CDC42EP3: view

Compounds for CDC42EP3 Gene

(1) HMDB Compounds for CDC42EP3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CDC42EP3: view

Transcripts for CDC42EP3 Gene

Unigene Clusters for CDC42EP3 Gene

CDC42 effector protein (Rho GTPase binding) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for CDC42EP3 Gene

GeneLoc Exon Structure for
CDC42EP3
ECgene alternative splicing isoforms for
CDC42EP3

Expression for CDC42EP3 Gene

mRNA expression in normal human tissues for CDC42EP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42EP3 Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42EP3 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP3 Gene Hs.369574

mRNA Expression by UniProt/SwissProt for CDC42EP3 Gene

Q9UKI2-BORG2_HUMAN
Tissue specificity: Highly expressed in the heart and weakly in the brain.
genes like me logo Genes that share expressions with CDC42EP3: view

Orthologs for CDC42EP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42EP3 36
  • 99.48 (n)
  • 100 (a)
CDC42EP3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42EP3 36
  • 89.24 (n)
  • 94.09 (a)
CDC42EP3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42EP3 36
  • 88.67 (n)
  • 94.07 (a)
CDC42EP3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42ep3 36
  • 87.53 (n)
  • 92.52 (a)
Cdc42ep3 16
Cdc42ep3 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42EP3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42EP3 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42ep3 36
  • 87.8 (n)
  • 94.09 (a)
chicken
(Gallus gallus)
Aves CDC42EP3 36
  • 73.17 (n)
  • 78.09 (a)
CDC42EP3 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42EP3 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42ep3 36
  • 68.12 (n)
  • 74.6 (a)
Str.12221 36
zebrafish
(Danio rerio)
Actinopterygii cdc42ep3 36
  • 64.83 (n)
  • 72.44 (a)
cdc42ep3 37
  • 42 (a)
OneToOne
wufc21b02 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7243 37
  • 20 (a)
OneToMany
Species with no ortholog for CDC42EP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP3 Gene

ENSEMBL:
Gene Tree for CDC42EP3 (if available)
TreeFam:
Gene Tree for CDC42EP3 (if available)

Paralogs for CDC42EP3 Gene

Selected SIMAP similar genes for CDC42EP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CDC42EP3 Gene

genes like me logo Genes that share paralogs with CDC42EP3: view

No data available for Paralogs for CDC42EP3 Gene

Variants for CDC42EP3 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7735 -- 37,645,365(-) CATAG(C/T)GAATT utr-variant-3-prime
rs9742 -- 37,642,351(-) CCCAG(A/C)GGGGA utr-variant-3-prime
rs10694 -- 37,644,996(-) AATAA(C/T)GGATT utr-variant-3-prime
rs15628 -- 37,645,728(+) CAACA(C/T)AAAAC utr-variant-3-prime
rs1127373 -- 37,641,968(-) ATAAC(A/C)CAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP3 Gene

Variant ID Type Subtype PubMed ID
dgv1173e1 CNV Complex 17122850
nsv833825 CNV Gain 17160897
nsv873880 CNV Loss 21882294
nsv508081 CNV Loss 20534489

Relevant External Links for CDC42EP3 Gene

HapMap Linkage Disequilibrium report
CDC42EP3

Disorders for CDC42EP3 Gene

Relevant External Links for CDC42EP3

Genetic Association Database (GAD)
CDC42EP3
genes like me logo Genes that share disorders with CDC42EP3: view

No data available for UniProtKB/Swiss-Prot for CDC42EP3 Gene

Publications for CDC42EP3 Gene

  1. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PMID: 11035016) Hirsch D.S. … Burbelo P.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. Human fertility protein PUMILIO2 interacts in vitro with testis mRNA encoding Cdc42 effector 3 (CEP3). (PMID: 17173092) Spik A. … Jaruzelska J. (Reprod Biol 2006) 3 23
  3. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. (PMID: 9535835) Alberts A.S. … Treisman R. (J. Biol. Chem. 1998) 2 3
  4. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for CDC42EP3 Gene

Sources for CDC42EP3 Gene

Back to Top

Content