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Aliases for CDC42EP2 Gene

Aliases for CDC42EP2 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 2 2 3
  • BORG1 3 4 6
  • CEP2 3 4 6
  • CRIB-Containing BOGR1 Protein 2 3
  • Binder Of Rho GTPases 1 3 4
  • Cdc42 Effector Protein 2 3

External Ids for CDC42EP2 Gene

Previous GeneCards Identifiers for CDC42EP2 Gene

  • GC11P067598
  • GC11P066764
  • GC11P064857
  • GC11P064838
  • GC11P065082
  • GC11P061409

Summaries for CDC42EP2 Gene

Entrez Gene Summary for CDC42EP2 Gene

  • CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

GeneCards Summary for CDC42EP2 Gene

CDC42EP2 (CDC42 Effector Protein (Rho GTPase Binding) 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include opioid peptide activity. An important paralog of this gene is CDC42EP3.

UniProtKB/Swiss-Prot for CDC42EP2 Gene

  • Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.

Gene Wiki entry for CDC42EP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP2 Gene

Genomics for CDC42EP2 Gene

Regulatory Elements for CDC42EP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42EP2 Gene

65,314,818 bp from pter
65,322,429 bp from pter
7,612 bases
Plus strand

Genomic View for CDC42EP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP2 Gene

Proteins for CDC42EP2 Gene

  • Protein details for CDC42EP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cdc42 effector protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RD85
    • Q9UNS0

    Protein attributes for CDC42EP2 Gene

    210 amino acids
    Molecular mass:
    22484 Da
    Quaternary structure:
    • Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.

neXtProt entry for CDC42EP2 Gene

Proteomics data for CDC42EP2 Gene at MOPED

Post-translational modifications for CDC42EP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42EP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDC42EP2 Gene

Domains for CDC42EP2 Gene

Protein Domains for CDC42EP2 Gene

Suggested Antigen Peptide Sequences for CDC42EP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O14613
  • The CRIB domain mediates interaction with CDC42
  • Contains 1 CRIB domain.
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP2: view

No data available for Gene Families for CDC42EP2 Gene

Function for CDC42EP2 Gene

Molecular function for CDC42EP2 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.

Gene Ontology (GO) - Molecular Function for CDC42EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001515 opioid peptide activity IEA --
GO:0005096 GTPase activator activity IMP 10430899
GO:0005515 protein binding IPI 11584266
GO:0017049 GTP-Rho binding IPI 11035016
genes like me logo Genes that share ontologies with CDC42EP2: view

Phenotypes for CDC42EP2 Gene

GenomeRNAi human phenotypes for CDC42EP2:
genes like me logo Genes that share phenotypes with CDC42EP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDC42EP2 Gene

Localization for CDC42EP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP2 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for CDC42EP2 Gene COMPARTMENTS Subcellular localization image for CDC42EP2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA 10430899
GO:0012505 endomembrane system IEA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP2: view

Pathways for CDC42EP2 Gene

genes like me logo Genes that share pathways with CDC42EP2: view

Pathways by source for CDC42EP2 Gene

3 Qiagen pathways for CDC42EP2 Gene
1 GeneGo (Thomson Reuters) pathway for CDC42EP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDC42EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization NAS 11035016
GO:0008360 regulation of cell shape IDA 11035016
GO:0030036 actin cytoskeleton organization IDA 10430899
GO:0030838 positive regulation of actin filament polymerization IDA 11035016
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP2: view

Compounds for CDC42EP2 Gene

(1) HMDB Compounds for CDC42EP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with CDC42EP2: view

Transcripts for CDC42EP2 Gene

mRNA/cDNA for CDC42EP2 Gene

(352) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC42EP2 Gene

CDC42 effector protein (Rho GTPase binding) 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42EP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP2 Gene

No ASD Table

Relevant External Links for CDC42EP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC42EP2 Gene

mRNA expression in normal human tissues for CDC42EP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CDC42EP2 Gene

This gene is overexpressed in Fetal testis (28.8), Prostate (18.6), Placenta (14.6), and Ovary (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42EP2 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP2 Gene Hs.343380

mRNA Expression by UniProt/SwissProt for CDC42EP2 Gene

Tissue specificity: Highly expressed in the heart. Weakly expressed in the pancreas and liver.
genes like me logo Genes that share expressions with CDC42EP2: view

Expression partners for CDC42EP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDC42EP2 Gene

Orthologs for CDC42EP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC42EP2 35
  • 87.46 (n)
  • 87.14 (a)
CDC42EP2 36
  • 87 (a)
(Canis familiaris)
Mammalia CDC42EP2 35
  • 89.52 (n)
  • 92.38 (a)
CDC42EP2 36
  • 91 (a)
(Mus musculus)
Mammalia Cdc42ep2 35
  • 85.4 (n)
  • 88.57 (a)
Cdc42ep2 16
Cdc42ep2 36
  • 87 (a)
(Pan troglodytes)
Mammalia CDC42EP2 35
  • 99.37 (n)
  • 99.52 (a)
CDC42EP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdc42ep2 35
  • 85.08 (n)
  • 88.1 (a)
(Monodelphis domestica)
Mammalia CDC42EP2 36
  • 76 (a)
(Gallus gallus)
Aves CDC42EP2 35
  • 70.45 (n)
  • 71.13 (a)
(Anolis carolinensis)
Reptilia CDC42EP2 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42ep2 35
  • 61.75 (n)
  • 68.31 (a)
Str.737 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53732 35
(Danio rerio)
Actinopterygii cdc42ep2 35
  • 60.45 (n)
  • 66.32 (a)
cdc42ep2 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7243 36
  • 19 (a)
Species with no ortholog for CDC42EP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP2 Gene

Gene Tree for CDC42EP2 (if available)
Gene Tree for CDC42EP2 (if available)

Paralogs for CDC42EP2 Gene

Paralogs for CDC42EP2 Gene

Selected SIMAP similar genes for CDC42EP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42EP2: view

Variants for CDC42EP2 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8358 -- 65,322,362(+) TCCCT(G/T)CCCAG utr-variant-3-prime
rs525141 -- 65,322,321(+) GCACT(C/G)GGGTG utr-variant-3-prime
rs542142 -- 65,320,418(+) GTGAG(C/T)TGAGA intron-variant
rs630055 -- 65,320,062(+) AGTCT(A/C)TAAGA intron-variant
rs1044605 -- 65,320,605(+) GCTGC(C/T)CACAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv832190 CNV Loss 17160897
esv2422285 CNV Deletion 17116639
nsv897714 CNV Loss 21882294
dgv1175n71 CNV Loss 21882294

Relevant External Links for CDC42EP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42EP2 Gene

Disorders for CDC42EP2 Gene

No disorders were found for CDC42EP2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CDC42EP2 Gene

Publications for CDC42EP2 Gene

  1. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 2 3 4
  2. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. (PMID: 11035016) Hirsch D.S. … Burbelo P.D. (J. Biol. Chem. 2001) 2 3 4
  3. Borg proteins control septin organization and are negatively regulated by Cdc42. (PMID: 11584266) Joberty G. … Macara I.G. (Nat. Cell Biol. 2001) 3 4
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CDC42EP2 Gene

Sources for CDC42EP2 Gene

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