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Aliases for CDC42EP1 Gene

Aliases for CDC42EP1 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 1 2 3
  • BORG5 3 4 6
  • MSE55 3 4 6
  • CEP1 3 4 6
  • 55 KDa Bone Marrow Stromal/Endothelial Cell Protein 2 3
  • Serum Constituent Protein 2 3
  • Binder Of Rho GTPases 5 3 4
  • Serum Protein MSE55 3 4
  • Cdc42 Effector Protein 1 3

External Ids for CDC42EP1 Gene

Previous GeneCards Identifiers for CDC42EP1 Gene

  • GC22P034571
  • GC22P036199
  • GC22P036281
  • GC22P037956
  • GC22P020924

Summaries for CDC42EP1 Gene

Entrez Gene Summary for CDC42EP1 Gene

  • CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42EP1 Gene

CDC42EP1 (CDC42 Effector Protein (Rho GTPase Binding) 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. An important paralog of this gene is CDC42EP5.

UniProtKB/Swiss-Prot for CDC42EP1 Gene

  • Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.

Gene Wiki entry for CDC42EP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP1 Gene

Genomics for CDC42EP1 Gene

Regulatory Elements for CDC42EP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42EP1 Gene

37,559,778 bp from pter
37,569,405 bp from pter
9,628 bases
Plus strand

Genomic View for CDC42EP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP1 Gene

Proteins for CDC42EP1 Gene

  • Protein details for CDC42EP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cdc42 effector protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K825
    • Q96GN1

    Protein attributes for CDC42EP1 Gene

    391 amino acids
    Molecular mass:
    40295 Da
    Quaternary structure:
    • Interacts with RHOQ and CDC42, in a GTP-dependent manner.

    Alternative splice isoforms for CDC42EP1 Gene


neXtProt entry for CDC42EP1 Gene

Proteomics data for CDC42EP1 Gene at MOPED

Post-translational modifications for CDC42EP1 Gene

  • Ubiquitination at Lys30
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC42EP1 Gene

Antibody Products

No data available for DME Specific Peptides for CDC42EP1 Gene

Domains for CDC42EP1 Gene

Protein Domains for CDC42EP1 Gene


Suggested Antigen Peptide Sequences for CDC42EP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q00587
  • The CRIB domain mediates interaction with CDC42
  • Contains 1 CRIB domain.
  • Belongs to the BORG/CEP family.
genes like me logo Genes that share domains with CDC42EP1: view

No data available for Gene Families for CDC42EP1 Gene

Function for CDC42EP1 Gene

Molecular function for CDC42EP1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.

Gene Ontology (GO) - Molecular Function for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with CDC42EP1: view
genes like me logo Genes that share phenotypes with CDC42EP1: view

Animal Model Products

CRISPR Products

miRNA for CDC42EP1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42EP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42EP1 Gene

Localization for CDC42EP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP1 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for CDC42EP1 Gene COMPARTMENTS Subcellular localization image for CDC42EP1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
plasma membrane 4
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CDC42EP1: view

Pathways for CDC42EP1 Gene

genes like me logo Genes that share pathways with CDC42EP1: view

Pathways by source for CDC42EP1 Gene

2 Qiagen pathways for CDC42EP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IDA 11035016
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP1: view

Compounds for CDC42EP1 Gene

(1) HMDB Compounds for CDC42EP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with CDC42EP1: view

Transcripts for CDC42EP1 Gene

Unigene Clusters for CDC42EP1 Gene

CDC42 effector protein (Rho GTPase binding) 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42EP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for CDC42EP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC42EP1 Gene

mRNA expression in normal human tissues for CDC42EP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CDC42EP1 Gene

This gene is overexpressed in Bone (20.9), Pancreas (7.9), and Heart (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDC42EP1 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP1 Gene Hs.225356

mRNA Expression by UniProt/SwissProt for CDC42EP1 Gene

Tissue specificity: Endothelial and bone marrow stromal cells
genes like me logo Genes that share expressions with CDC42EP1: view

Expression partners for CDC42EP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDC42EP1 Gene

Orthologs for CDC42EP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC42EP1 35
  • 85.66 (n)
  • 83.24 (a)
CDC42EP1 36
  • 81 (a)
(Canis familiaris)
Mammalia CDC42EP1 35
  • 83.33 (n)
  • 77.54 (a)
CDC42EP1 36
  • 75 (a)
(Mus musculus)
Mammalia Cdc42ep1 35
  • 77.23 (n)
  • 74.29 (a)
Cdc42ep1 16
Cdc42ep1 36
  • 69 (a)
(Pan troglodytes)
Mammalia CDC42EP1 35
  • 99.05 (n)
  • 98.71 (a)
CDC42EP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cdc42ep1 35
  • 78.71 (n)
  • 75.54 (a)
(Monodelphis domestica)
Mammalia CDC42EP1 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia CDC42EP1 36
  • 47 (a)
(Gallus gallus)
Aves CDC42EP1 35
  • 67.69 (n)
  • 64.62 (a)
CDC42EP1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia CDC42EP1 36
  • 33 (a)
(Danio rerio)
Actinopterygii CDC42EP1 (1 of 2) 36
  • 46 (a)
CDC42EP1 (2 of 2) 36
  • 32 (a)
Species with no ortholog for CDC42EP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP1 Gene

Gene Tree for CDC42EP1 (if available)
Gene Tree for CDC42EP1 (if available)

Paralogs for CDC42EP1 Gene

Paralogs for CDC42EP1 Gene

Selected SIMAP similar genes for CDC42EP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDC42EP1: view

Variants for CDC42EP1 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2076087 -- 37,564,358(+) CGTCA(A/G)TTTGA intron-variant, upstream-variant-2KB
rs2076088 -- 37,564,718(+) gttac(G/T)tcact intron-variant, upstream-variant-2KB
rs2235335 -- 37,562,156(+) AAATC(C/G)TCTTC intron-variant, upstream-variant-2KB
rs2235336 -- 37,562,261(+) TTTCC(A/G)TCTGT intron-variant, upstream-variant-2KB
rs2235337 -- 37,562,305(+) TCCTG(A/G)GCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294
nsv834191 CNV Loss 17160897

Relevant External Links for CDC42EP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42EP1 Gene

Disorders for CDC42EP1 Gene

No disorders were found for CDC42EP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CDC42EP1 Gene

Publications for CDC42EP1 Gene

  1. cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression. (PMID: 1629197) Bahou W.F. … Wicha M.S. (J. Biol. Chem. 1992) 2 3 4
  2. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. (PMID: 10430899) Burbelo P.D. … Spiegel S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for CDC42EP1 Gene

Sources for CDC42EP1 Gene

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