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Aliases for CDC42EP1 Gene

Aliases for CDC42EP1 Gene

  • CDC42 Effector Protein (Rho GTPase Binding) 1 2 3
  • BORG5 3 4 6
  • MSE55 3 4 6
  • CEP1 3 4 6
  • 55 KDa Bone Marrow Stromal/Endothelial Cell Protein 2 3
  • Serum Constituent Protein 2 3
  • Binder Of Rho GTPases 5 3 4
  • Serum Protein MSE55 3 4
  • Cdc42 Effector Protein 1 3

External Ids for CDC42EP1 Gene

Summaries for CDC42EP1 Gene

Entrez Gene Summary for CDC42EP1 Gene

  • CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42EP1 Gene

CDC42EP1 (CDC42 Effector Protein (Rho GTPase Binding) 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. An important paralog of this gene is CDC42EP5.

UniProtKB/Swiss-Prot for CDC42EP1 Gene

  • Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.

Gene Wiki entry for CDC42EP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42EP1 Gene

Genomics for CDC42EP1 Gene

Genomic Location for CDC42EP1 Gene

Start:
37,559,778 bp from pter
End:
37,569,405 bp from pter
Size:
9,628 bases
Orientation:
Plus strand

Genomic View for CDC42EP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42EP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42EP1 Gene

Regulatory Elements for CDC42EP1 Gene

Proteins for CDC42EP1 Gene

  • Protein details for CDC42EP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00587-BORG5_HUMAN
    Recommended name:
    Cdc42 effector protein 1
    Protein Accession:
    Q00587
    Secondary Accessions:
    • A8K825
    • Q96GN1

    Protein attributes for CDC42EP1 Gene

    Size:
    391 amino acids
    Molecular mass:
    40295 Da
    Quaternary structure:
    • Interacts with RHOQ and CDC42, in a GTP-dependent manner.

    Alternative splice isoforms for CDC42EP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC42EP1 Gene

Proteomics data for CDC42EP1 Gene at MOPED

Post-translational modifications for CDC42EP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys30

Other Protein References for CDC42EP1 Gene

No data available for DME Specific Peptides for CDC42EP1 Gene

Domains for CDC42EP1 Gene

Protein Domains for CDC42EP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BORG5_HUMAN
Domain:
  • The CRIB domain mediates interaction with CDC42:
    • Q00587
  • Contains 1 CRIB domain.:
    • Q00587
Family:
  • Belongs to the BORG/CEP family.:
    • Q00587
genes like me logo Genes that share domains with CDC42EP1: view

No data available for Gene Families for CDC42EP1 Gene

Function for CDC42EP1 Gene

Molecular function for CDC42EP1 Gene

UniProtKB/Swiss-Prot Function: Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.

Gene Ontology (GO) - Molecular Function for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with CDC42EP1: view
genes like me logo Genes that share phenotypes with CDC42EP1: view

miRNA for CDC42EP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42EP1 Gene

Localization for CDC42EP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42EP1 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42EP1 Gene COMPARTMENTS Subcellular localization image for CDC42EP1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
plasma membrane 4
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CDC42EP1: view

Pathways for CDC42EP1 Gene

genes like me logo Genes that share pathways with CDC42EP1: view

Pathways by source for CDC42EP1 Gene

2 Qiagen pathways for CDC42EP1 Gene

Gene Ontology (GO) - Biological Process for CDC42EP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IDA 11035016
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IDA 11035016
genes like me logo Genes that share ontologies with CDC42EP1: view

Compounds for CDC42EP1 Gene

(1) HMDB Compounds for CDC42EP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CDC42EP1: view

Transcripts for CDC42EP1 Gene

Unigene Clusters for CDC42EP1 Gene

CDC42 effector protein (Rho GTPase binding) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42EP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for CDC42EP1 Gene

GeneLoc Exon Structure for
CDC42EP1
ECgene alternative splicing isoforms for
CDC42EP1

Expression for CDC42EP1 Gene

mRNA expression in normal human tissues for CDC42EP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDC42EP1 Gene

SOURCE GeneReport for Unigene cluster for CDC42EP1 Gene Hs.225356

mRNA Expression by UniProt/SwissProt for CDC42EP1 Gene

Q00587-BORG5_HUMAN
Tissue specificity: Endothelial and bone marrow stromal cells
genes like me logo Genes that share expressions with CDC42EP1: view

Orthologs for CDC42EP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC42EP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42EP1 36
  • 99.05 (n)
  • 98.71 (a)
CDC42EP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC42EP1 36
  • 85.66 (n)
  • 83.24 (a)
CDC42EP1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42EP1 36
  • 83.33 (n)
  • 77.54 (a)
CDC42EP1 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42ep1 36
  • 77.23 (n)
  • 74.29 (a)
Cdc42ep1 16
Cdc42ep1 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42EP1 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42EP1 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42ep1 36
  • 78.71 (n)
  • 75.54 (a)
chicken
(Gallus gallus)
Aves CDC42EP1 36
  • 67.69 (n)
  • 64.62 (a)
CDC42EP1 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42EP1 37
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CDC42EP1 (1 of 2) 37
  • 46 (a)
OneToMany
CDC42EP1 (2 of 2) 37
  • 32 (a)
OneToMany
Species with no ortholog for CDC42EP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC42EP1 Gene

ENSEMBL:
Gene Tree for CDC42EP1 (if available)
TreeFam:
Gene Tree for CDC42EP1 (if available)

Paralogs for CDC42EP1 Gene

Paralogs for CDC42EP1 Gene

Selected SIMAP similar genes for CDC42EP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDC42EP1: view

Variants for CDC42EP1 Gene

Sequence variations from dbSNP and Humsavar for CDC42EP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2076087 -- 37,564,358(+) CGTCA(A/G)TTTGA intron-variant, upstream-variant-2KB
rs2076088 -- 37,564,718(+) gttac(G/T)tcact intron-variant, upstream-variant-2KB
rs2235335 -- 37,562,156(+) AAATC(C/G)TCTTC intron-variant, upstream-variant-2KB
rs2235336 -- 37,562,261(+) TTTCC(A/G)TCTGT intron-variant, upstream-variant-2KB
rs2235337 -- 37,562,305(+) TCCTG(A/G)GCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDC42EP1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294
nsv834191 CNV Loss 17160897

Relevant External Links for CDC42EP1 Gene

HapMap Linkage Disequilibrium report
CDC42EP1

Disorders for CDC42EP1 Gene

No disorders were found for CDC42EP1 Gene.

No data available for UniProtKB/Swiss-Prot for CDC42EP1 Gene

Publications for CDC42EP1 Gene

  1. cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression. (PMID: 1629197) Bahou W.F. … Wicha M.S. (J. Biol. Chem. 1992) 2 3 4
  2. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. (PMID: 10430899) Burbelo P.D. … Spiegel S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for CDC42EP1 Gene

Sources for CDC42EP1 Gene

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