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Aliases for CDC42BPG Gene

Aliases for CDC42BPG Gene

  • CDC42 Binding Protein Kinase Gamma 2 3 5
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Gamma 3 4
  • CDC42 Binding Protein Kinase Gamma (DMPK-Like) 2 3
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • Myotonic Dystrophy Protein Kinase-Like Gamma 3 4
  • DMPK-Like Gamma 3 4
  • EC 2.7.11.1 4 61
  • MRCK Gamma 3 4
  • DMPK2 3 4
  • MRCKG 3 4
  • Myotonic Dystrophy Protein Kinase Like Protein 3
  • Serine/Threonine-Protein Kinase MRCK Gamma 3
  • CDC42-Binding Protein Kinase Gamma 4
  • KAPPA-200 3
  • MRCKgamma 3
  • EC 2.7.11 61
  • HSMDPKIN 3

External Ids for CDC42BPG Gene

Previous GeneCards Identifiers for CDC42BPG Gene

  • GC11M064348
  • GC11M064591
  • GC11M060918

Summaries for CDC42BPG Gene

GeneCards Summary for CDC42BPG Gene

CDC42BPG (CDC42 Binding Protein Kinase Gamma) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for CDC42BPG Gene

  • May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPG Gene

Genomics for CDC42BPG Gene

Regulatory Elements for CDC42BPG Gene

Enhancers for CDC42BPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064354 1.4 FANTOM5 ENCODE 10.2 +486.7 486699 6.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF207 ZNF143 FOS PLCB3 LOC102723878 ZFPL1 ENSG00000257086 POLA2 VPS51 ATG2A CDC42BPG MRPL49 SNX15
GH11F064237 1.4 Ensembl ENCODE 9.8 +599.4 599355 16.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 TRPT1 PPP1R14B LOC102723878 VEGFB ENSG00000257086 MRPL49 TRMT112 KCNK4 ZFPL1 PLCB3
GH11F064267 1.2 ENCODE 9.8 +574.0 573974 7.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 FAU MRPL49 TRPT1 ENSG00000257086 C11orf84
GH11F064846 1.9 FANTOM5 Ensembl ENCODE 6 -15.6 -15599 27.0 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 EHD1 NEAT1 KAT5 MAP4K2 SNX15 MIR192 MEN1 SSSCA1-AS1 EHBP1L1 FAU
GH11F065069 1 Ensembl ENCODE 10.7 -224.8 -224828 1.0 USF1 SAP130 MAX ZNF384 CEBPG GATAD2A TFE3 ZNF740 HLF CBFB SNX15 ARL2 TM7SF2 ENSG00000254501 CDC42BPG MAJIN EHD1 GC11M065053 GC11M065079 PIR38481
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC42BPG on UCSC Golden Path with GeneCards custom track

Promoters for CDC42BPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563705 73 1201 HDGF PKNOX1 ARNT SIN3A ZNF2 ETS1 GLIS2 ELK1 ZNF143 ZNF263

Genomic Location for CDC42BPG Gene

Chromosome:
11
Start:
64,823,387 bp from pter
End:
64,844,673 bp from pter
Size:
21,287 bases
Orientation:
Minus strand

Genomic View for CDC42BPG Gene

Genes around CDC42BPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPG Gene

Proteins for CDC42BPG Gene

  • Protein details for CDC42BPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DT37-MRCKG_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK gamma
    Protein Accession:
    Q6DT37
    Secondary Accessions:
    • O00565

    Protein attributes for CDC42BPG Gene

    Size:
    1551 amino acids
    Molecular mass:
    172459 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity).

neXtProt entry for CDC42BPG Gene

Selected DME Specific Peptides for CDC42BPG Gene

Q6DT37:
  • DTSNFDVDD
  • KVIGRGAF
  • CDWWSLG
  • RLADFGSCL
  • PLKKVRPLN
  • GTPDYISPE
  • GETPFYAESLVETYGKIMNH
  • VAVGTPDYISPEIL
  • CFREERDVLV
  • AFSGHHLPFVGFTYTS
  • LHYAFQD
  • GGDLLTLLS
  • RGYLQALA
  • LYLVMDY

Post-translational modifications for CDC42BPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDC42BPG Gene

Suggested Antigen Peptide Sequences for CDC42BPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DT37

UniProtKB/Swiss-Prot:

MRCKG_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 CRIB domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CDC42BPG: view

Function for CDC42BPG Gene

Molecular function for CDC42BPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity).
UniProtKB/Swiss-Prot Function:
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

Enzyme Numbers (IUBMB) for CDC42BPG Gene

Gene Ontology (GO) - Molecular Function for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15194684
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS 9341881
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding NAS 9341881
genes like me logo Genes that share ontologies with CDC42BPG: view
genes like me logo Genes that share phenotypes with CDC42BPG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC42BPG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPG Gene

Localization for CDC42BPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPG Gene

Cytoplasm. Note=Concentrates at the leading edge of cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC42BPG gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031252 cell leading edge IDA 15194684
genes like me logo Genes that share ontologies with CDC42BPG: view

Pathways & Interactions for CDC42BPG Gene

SuperPathways for CDC42BPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation NAS 9341881
GO:0016310 phosphorylation IEA --
GO:0031532 actin cytoskeleton reorganization ISS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with CDC42BPG: view

No data available for Pathways by source and SIGNOR curated interactions for CDC42BPG Gene

Drugs & Compounds for CDC42BPG Gene

(3) Drugs for CDC42BPG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for CDC42BPG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CDC42BPG: view

Transcripts for CDC42BPG Gene

Unigene Clusters for CDC42BPG Gene

CDC42 binding protein kinase gamma (DMPK-like):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPG Gene

No ASD Table

Relevant External Links for CDC42BPG Gene

GeneLoc Exon Structure for
CDC42BPG
ECgene alternative splicing isoforms for
CDC42BPG

Expression for CDC42BPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC42BPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42BPG Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.6), Skin - Sun Exposed (Lower leg) (x5.1), Brain - Cerebellar Hemisphere (x4.8), Brain - Cerebellum (x4.7), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for CDC42BPG Gene

This gene is overexpressed in Fetal Brain (35.3) and Platelet (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC42BPG Gene



NURSA nuclear receptor signaling pathways regulating expression of CDC42BPG Gene:

CDC42BPG

SOURCE GeneReport for Unigene cluster for CDC42BPG Gene:

Hs.293590

mRNA Expression by UniProt/SwissProt for CDC42BPG Gene:

Q6DT37-MRCKG_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with CDC42BPG: view

Primer Products

No data available for Protein tissue co-expression partners for CDC42BPG Gene

Orthologs for CDC42BPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPG 34 35
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia CDC42BPG 34 35
  • 87.75 (n)
dog
(Canis familiaris)
Mammalia CDC42BPG 34 35
  • 87.15 (n)
mouse
(Mus musculus)
Mammalia Cdc42bpg 34 16 35
  • 83.98 (n)
rat
(Rattus norvegicus)
Mammalia Cdc42bpg 34
  • 83.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPG 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammali