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CDC42BPG Gene

protein-coding   GIFtS: 51
GCID: GC11M064591

CDC42 Binding Protein Kinase Gamma (DMPK-Like)

  See CDC42BPG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC42 Binding Protein Kinase Gamma (DMPK-Like)1 2     MRCK Gamma2 3
MRCKG2 3 5     EC 2.7.11.13 8
Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Gamma2 3     HSMDPKIN2
Myotonic Dystrophy Protein Kinase-Like Alpha2 3     KAPPA-2002
Myotonic Dystrophy Protein Kinase-Like Gamma2 3     MRCKgamma2
DMPK22 3     Myotonic Dystrophy Protein Kinase Like Protein2
CDC42-Binding Protein Kinase Gamma2 3     Serine/Threonine-Protein Kinase MRCK Gamma2
DMPK-Like Gamma2 3     EC 2.7.118

External Ids:    HGNC: 298291   Entrez Gene: 555612   Ensembl: ENSG000001712197   OMIM: 6139915   UniProtKB: Q6DT373   

Export aliases for CDC42BPG gene to outside databases

Previous GC identifers: GC11M064348 GC11M060918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDC42BPG Gene:
CDC42BPG (CDC42 binding protein kinase gamma (DMPK-like)) is a protein-coding gene. Diseases associated with CDC42BPG include myotonic dystrophy. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is DMPK.

UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37
Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin
contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42BPG gene promoter:
         Sp1   RREB-1   Lmo2   AP-2gamma   LCR-F1   AREB6   c-Myb   ZID   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC42BPG promoter sequence
   Search Chromatin IP Primers for CDC42BPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42BPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

CDC42BPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42BPG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064591:  view genomic region     (about GC identifiers)

Start:
64,590,859 bp from pter      End:
64,612,041 bp from pter
Size:
21,183 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MRCK gamma  
Size: 1551 amino acids; 172459 Da
Cofactor: Magnesium
Subunit: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not
GDP-bound CDC42 (By similarity)
Secondary accessions: O00565

Explore the universe of human proteins at neXtProt for CDC42BPG: NX_Q6DT37

Explore proteomics data for CDC42BPG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDC42BPG (Q6DT37) (see all 14)
     CDWWSLG  LYLVMDY  LHYAFQD  RGYLQALA 


    See CDC42BPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059995.2  
    ENSEMBL proteins: 
     ENSP00000345133  

    CDC42BPG Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CDC42BPG (2 products) 

     
    antibodies-online peptides for CDC42BPG

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    antibodies-online antibodies for CDC42BPG (3 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC42 binding protein kinase gamma (DMPK-like)
    GEK subfamily
    Other AGC kinases

    Selected InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR014930 Myotonic_dystrophy_kinase_coil
     IPR026611 Ser/Thr_kinase_MRCK
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6DT37

    ProtoNet protein and cluster: Q6DT37

    3 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001180 Citron-like
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDC42BPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRCKG_HUMAN, Q6DT37
    Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin
    contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Maintained in an inactive, closed conformation by an interaction between the kinase domain and
    the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site
    disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by
    transautophosphorylation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15194684
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS9341881
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
         
    Find genes that share ontologies with CDC42BPG           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDC42BPG:
     Decreased focal adhesion (FA)   Increased colony dispersion (i  Paclitaxel antagonistic effect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDC42BPG

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    hsa-miR-125a-5p hsa-miR-1271 hsa-miR-654-5p hsa-miR-125b hsa-miR-670 hsa-miR-608 hsa-miR-96 hsa-miR-541
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    Addgene plasmids for CDC42BPG 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRCKG_HUMAN, Q6DT37: Cytoplasm. Note=Concentrates at the leading edge of cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome ----
    GO:0031252cell leading edge IDA15194684

    Find genes that share ontologies with CDC42BPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC42BPG
    Interactions:

        Search GeneGlobe Interaction Network for CDC42BPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CDC42BPG (Q6DT371, 2, 3 ENSP000003451334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 3, ENSP000003299674EBI-689124,EBI-356402 I2D: score=1 STRING: ENSP00000329967
    SFNP319472, 3MINT-3976305 I2D: score=1 
    RHOQP170813, ENSP000002387384I2D: score=2 STRING: ENSP00000238738
    CDC42P609533, ENSP000003144584I2D: score=3 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS9341881
    GO:0031532actin cytoskeleton reorganization ISS--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with CDC42BPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CDC42BPG (MRCKG)

    Selected HMDB Compounds for CDC42BPG (see all 847)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC42BPG gene: 
    NM_017525.2  

    Unigene Cluster for CDC42BPG:

    CDC42 binding protein kinase gamma (DMPK-like)
    Hs.293590  [show with all ESTs]
    Unigene Representative Sequence: NM_017525
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342711(uc001obs.4) ENST00000491280 ENST00000468512 ENST00000480767

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    Selected qRT-PCR Assays for microRNAs that regulate CDC42BPG (see all 9):
    hsa-miR-125a-5p hsa-miR-1271 hsa-miR-654-5p hsa-miR-125b hsa-miR-670 hsa-miR-608 hsa-miR-96 hsa-miR-541
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      QuantiFast Probe-based Assays in human, mouse, rat CDC42BPG

    Additional mRNA sequence: 

    AF001543.1 AF001544.1 AY648038.1 Y12337.1 

    4 DOTS entries:

    DT.428320  DT.40302887  DT.91752275  DT.95212265 

    Selected AceView cDNA sequences (see all 25):

    AW992403 AY648038 NM_017525 Y12337 BQ947017 BI793270 CK821112 BG678034 
    BG752641 BE793390 AF001544 AF001543 AW516225 BG105639 H01451 BI792977 
    CK821111 AA809737 BF991223 BG952299 BG014499 AW814108 BF357216 BF357213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42BPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATTCGGA
    CDC42BPG Expression
    About this image


    CDC42BPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Pons
    CDC42BPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42BPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293590

    UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37
    Tissue specificity: Expressed in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDC42BPG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42bpg1 , 5 CDC42 binding protein kinase gamma (DMPK-like)1, 5 83.98(n)1
    85.34(a)1
      19 (4.43 cM)5
    2405051  NM_001033342.11  NP_001028514.11 
     63064565 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42BPG6
    CDC42 binding protein kinase gamma (DMPK-like)
    47(a)
    1 ↔ 1
    GL345031.1(1363-14139)
    fruit fly
    (Drosophila melanogaster)
    Insecta gek6
    genghis khan
    35(a)
    1 → many
    2R(19979600-19986157)
    worm
    (Caenorhabditis elegans)
    Secernentea mrck-16
    Protein MRCK-1 (mrck-1) mRNA, complete cds
    34(a)
    1 → many
    V(6257401-6267191) WBGene00006437


    ENSEMBL Gene Tree for CDC42BPG (if available)
    TreeFam Gene Tree for CDC42BPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC42BPG gene
    DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  ROCK12  
    CDC42BPA2  LATS22  ROCK22  
    Selected SIMAP similar genes for CDC42BPG using alignment to 1 protein entry:     MRCKG_HUMAN(see all similar genes):
    CDC42BPB    DMPK    KIN27    CDC42BPA    DKFZp686P1738    PRKACA
    SGK2    STK38    PRKACG    PRKX    PRKY    STK38L
    RPS6KB1    SGK1    SGK3    SGKL    PRKACB    RPS6KB2

    Find genes that share paralogs with CDC42BPG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42BPG (see all 788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408414
    A glioblastoma multiforme sample4--see VAR_0408412 S F mis40--------
    rs1162743611,2
    F--64591201(+) TCCCCG/AATGGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs781378741,2
    C,F--64591215(+) ATTGGC/ATGACA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs773565611,2
    F--64591216(+) TTGGCT/GGACAG 1 -- int11Minor allele frequency- G:0.02NA 120
    rs582755891,2
    F--64591335(+) TCCTTC/TGTCCC 1 -- int11Minor allele frequency- T:0.09WA 118
    rs38250151,2
    C,F,H--64591386(-) AGGTGA/GTAGGA 1 -- int1 ese310Minor allele frequency- G:0.37NS EA NA 664
    rs127872111,2
    C,H--64591412(+) ggataG/Tgagga 1 -- int1 ese3 trp34Minor allele frequency- T:0.00NS EA 420
    rs715396981,2
    C,F--64591434(+) TCCTTC/TGCCTA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs127872261,2
    C,H--64591437(+) ttcgcC/Atacat 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1115151441,2
    C--64591517(+) GAGACA/GGGGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CDC42BPG (64590859 - 64612041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDC42BPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1173n71CNV Loss21882294
    nsv469962CNV Loss18288195
    nsv832189CNV Loss17160897
    dgv1172n71CNV Loss21882294
    nsv528506CNV Loss19592680
    dgv1171n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613991    OMIM disorders: --

    1 disease for CDC42BPG:    
    About MalaCards
    myotonic dystrophy


    Find genes that share disorders with CDC42BPG           About GenesLikeMe

    Genetic Association Database (GAD): CDC42BPG

    Export disorders for CDC42BPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42BPG gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CDC42BPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the human myotonic dystrophy kinase-related Cdc42- binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. (PubMed id 15194684)1, 2, 3, 9 Ng Y.... Leung T. (J. Biol. Chem. 2004)
    2. The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PubMed id 9341881)1, 2, 3 Kedra D.... Dumanski J. (Hum. Genet. 1997)
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. (PubMed id 21768215)1 Tin A....KAPttgen A. (Hum. Mol. Genet. 2011)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    9. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1 Guru S.C.... Chandrasekharappa S.C. (Genome Res. 1997)
    10. Myotonic dystrophy protein kinase monoclonal antibody generation from a coiled-coil template. (PubMed id 16680721)9 Helmke S.M....Perryman M.B. (J. Mol. Recognit. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55561 HGNC: 29829 AceView: HSMDPKIN Ensembl:ENSG00000171219 euGenes: HUgn55561
    ECgene: CDC42BPG H-InvDB: CDC42BPG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC42BPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDC42BPG gene:
    Search GeneIP for patents involving CDC42BPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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