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Aliases for CDC42BPG Gene

Aliases for CDC42BPG Gene

  • CDC42 Binding Protein Kinase Gamma (DMPK-Like) 2 3
  • MRCKG 3 4 6
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Gamma 3 4
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • Myotonic Dystrophy Protein Kinase-Like Gamma 3 4
  • CDC42-Binding Protein Kinase Gamma 3 4
  • DMPK-Like Gamma 3 4
  • EC 4 63
  • MRCK Gamma 3 4
  • DMPK2 3 4
  • Myotonic Dystrophy Protein Kinase Like Protein 3
  • Serine/Threonine-Protein Kinase MRCK Gamma 3
  • KAPPA-200 3
  • MRCKgamma 3
  • EC 2.7.11 63

External Ids for CDC42BPG Gene

Previous GeneCards Identifiers for CDC42BPG Gene

  • GC11M064348
  • GC11M064591
  • GC11M060918

Summaries for CDC42BPG Gene

GeneCards Summary for CDC42BPG Gene

CDC42BPG (CDC42 Binding Protein Kinase Gamma (DMPK-Like)) is a Protein Coding gene. Diseases associated with CDC42BPG include myotonic dystrophy. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for CDC42BPG Gene

  • May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPG Gene

Genomics for CDC42BPG Gene

Regulatory Elements for CDC42BPG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42BPG Gene

64,823,387 bp from pter
64,844,569 bp from pter
21,183 bases
Minus strand

Genomic View for CDC42BPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42BPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPG Gene

Proteins for CDC42BPG Gene

  • Protein details for CDC42BPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase MRCK gamma
    Protein Accession:
    Secondary Accessions:
    • O00565

    Protein attributes for CDC42BPG Gene

    1551 amino acids
    Molecular mass:
    172459 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity).

neXtProt entry for CDC42BPG Gene

Proteomics data for CDC42BPG Gene at MOPED

Post-translational modifications for CDC42BPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC42BPG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CDC42BPG Gene

Gene Families for CDC42BPG Gene

Suggested Antigen Peptide Sequences for CDC42BPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6DT37
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 CRIB domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CDC42BPG: view

Function for CDC42BPG Gene

Molecular function for CDC42BPG Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity).
UniProtKB/Swiss-Prot Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

Enzyme Numbers (IUBMB) for CDC42BPG Gene

Gene Ontology (GO) - Molecular Function for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15194684
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity NAS 9341881
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with CDC42BPG: view
genes like me logo Genes that share phenotypes with CDC42BPG: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDC42BPG Gene

Localization for CDC42BPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPG Gene

Cytoplasm. Note=Concentrates at the leading edge of cells.

Subcellular locations from

Jensen Localization Image for CDC42BPG Gene COMPARTMENTS Subcellular localization image for CDC42BPG gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031252 cell leading edge IDA 15194684
genes like me logo Genes that share ontologies with CDC42BPG: view

Pathways for CDC42BPG Gene

SuperPathways for CDC42BPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC42BPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation NAS 9341881
GO:0031532 actin cytoskeleton reorganization ISS --
GO:0035556 intracellular signal transduction IEA --
GO:0050790 regulation of catalytic activity --
genes like me logo Genes that share ontologies with CDC42BPG: view

No data available for Pathways by source for CDC42BPG Gene

Compounds for CDC42BPG Gene

(847) HMDB Compounds for CDC42BPG Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available
genes like me logo Genes that share compounds with CDC42BPG: view

Transcripts for CDC42BPG Gene

Unigene Clusters for CDC42BPG Gene

CDC42 binding protein kinase gamma (DMPK-like):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42BPG

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CDC42BPG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPG Gene

No ASD Table

Relevant External Links for CDC42BPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC42BPG Gene

mRNA expression in normal human tissues for CDC42BPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42BPG Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (5.6), Skin - Sun Exposed (Lower leg) (5.1), Brain - Cerebellar Hemisphere (4.8), Brain - Cerebellum (4.7), and Esophagus - Mucosa (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDC42BPG Gene

SOURCE GeneReport for Unigene cluster for CDC42BPG Gene Hs.293590

mRNA Expression by UniProt/SwissProt for CDC42BPG Gene

Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expressions with CDC42BPG: view

In Situ Assay Products

Orthologs for CDC42BPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC42BPG 35
  • 99.36 (n)
  • 99.36 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CDC42BPG 35
  • 87.75 (n)
  • 88.05 (a)
  • 88 (a)
(Canis familiaris)
Mammalia CDC42BPG 35
  • 87.15 (n)
  • 87.65 (a)
  • 86 (a)
(Mus musculus)
Mammalia Cdc42bpg 35
  • 83.98 (n)
  • 85.34 (a)
Cdc42bpg 16
Cdc42bpg 36
  • 85 (a)
(Monodelphis domestica)
Mammalia CDC42BPG 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CDC42BPG 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Cdc42bpg 35
  • 83.62 (n)
  • 84.96 (a)
(Anolis carolinensis)
Reptilia CDC42BPG 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta gek 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrck-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 36
  • 38 (a)
Species with no ortholog for CDC42BPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDC42BPG Gene

Gene Tree for CDC42BPG (if available)
Gene Tree for CDC42BPG (if available)

Paralogs for CDC42BPG Gene

Paralogs for CDC42BPG Gene

Selected SIMAP similar genes for CDC42BPG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC42BPG: view

Variants for CDC42BPG Gene

Sequence variations from dbSNP and Humsavar for CDC42BPG Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs478817 -- 64,845,432(+) GGCAA(A/G)GAGAG upstream-variant-2KB
rs480455 -- 64,845,551(+) AAGGG(G/T)GGGAC upstream-variant-2KB
rs483288 -- 64,828,468(+) AGAGA(G/T)AGTGG intron-variant
rs494252 -- 64,832,530(+) AACAG(G/T)TCAGA intron-variant
rs541525 -- 64,838,217(+) GGCCC(A/G)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPG Gene

Variant ID Type Subtype PubMed ID
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
dgv1172n71 CNV Loss 21882294
nsv832189 CNV Loss 17160897
nsv469962 CNV Loss 18288195
dgv1173n71 CNV Loss 21882294

Relevant External Links for CDC42BPG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPG Gene

Disorders for CDC42BPG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDC42BPG Gene including...

Search for CDC42BPG Gene in MalaCards »

Relevant External Links for CDC42BPG

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CDC42BPG: view

No data available for UniProtKB/Swiss-Prot for CDC42BPG Gene

Publications for CDC42BPG Gene

  1. Expression of the human myotonic dystrophy kinase-related Cdc42- binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. (PMID: 15194684) Ng Y. … Leung T. (J. Biol. Chem. 2004) 2 3 4 23
  2. The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PMID: 9341881) Kedra D. … Dumanski J. (Hum. Genet. 1997) 2 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. (PMID: 21768215) Tin A. … KAPttgen A. (Hum. Mol. Genet. 2011) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for CDC42BPG Gene

Sources for CDC42BPG Gene

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