CDC42BPG Gene
protein-coding GIFtS: 48
GCID: GC11M064591
|
|
CDC42 binding protein kinase gamma (DMPK-like)
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Aliases
for CDC42BPG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDC42 Binding Protein Kinase Gamma (DMPK-Like)1 2 | | DMPK-Like Gamma2 3 | | DMPK21 2 3 | | MRCK Gamma2 3 | | HSMDPKIN1 2 | | EC 2.7.11.13 8 | | MRCKgamma1 2 | | Kappa-2001 | | Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Gamma2 3 | | KAPPA-2002 | | Myotonic Dystrophy Protein Kinase-Like Alpha2 3 | | Myotonic Dystrophy Protein Kinase Like Protein2 | | Myotonic Dystrophy Protein Kinase-Like Gamma2 3 | | Serine/Threonine-Protein Kinase MRCK Gamma2 | | MRCKG2 3 | | EC 2.7.118 | | CDC42-Binding Protein Kinase Gamma2 3 | | |
Export aliases for CDC42BPG gene to outside databasesPrevious GC identifers: GC11M064348 GC11M060918 |
Summaries
for CDC42BPG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosincontractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (Bysimilarity)
|
Genomic Views
for CDC42BPG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC42BPG gene promoter:
Sp1 RREB-1 Lmo2 AP-2gamma LCR-F1 AREB6 c-Myb ZID ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC42BPG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42BPG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13CDC42BPG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064591: view genomic region
(about GC identifiers)
Start:
|
64,590,859 bp from pter |
End:
|
64,612,041 bp from pter |
Size:
|
21,183 bases |
Orientation:
|
minus strand |
|
Proteins
for CDC42BPG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase MRCK gamma Size: 1551 amino acids; 172459 Da
Cofactor: Magnesium
Subunit: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-boundCDC42 (By similarity)
Subcellular location: Cytoplasm. Note=Concentrates at the leading edge of cells
Secondary accessions: O00565Explore the universe of human proteins at neXtProt for CDC42BPG: NX_Q6DT37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DT37
4/14 DME Specific Peptides for CDC42BPG (Q6DT37) (see all 14)
CDC42BPG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059995.2
ENSEMBL proteins: ENSP00000345133
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CDC42BPG for ontologies About GeneDecksing
CDC42BPG Antibody Products:
Assay Products for CDC42BPG: |
Protein
Domains /
Families
for CDC42BPG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDC42BPG for domains About GeneDecksing
5/14 InterPro domains/families (see all 14):Graphical View of Domain Structure for InterPro Entry Q6DT37ProtoNet protein and cluster: Q6DT37 3 Blocks protein families: IPB000961 Protein kinase C-terminal domain IPB001180 Citron-like IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 CNH domainSimilarity: Contains 1 CRIB domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 protein kinase domain |
Function
for CDC42BPG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosincontractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (Bysimilarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Maintained in an inactive, closed conformation by an interaction between the kinase domain and thenegative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disruptsthis, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation bytransautophosphorylation (By similarity)Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPG |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CDC42BPG for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CDC42BPG:
|
Pathways & Interactions
for CDC42BPG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC42BPG
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for CDC42BPG (Q6DT371, 2, 3 ENSP000003451334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CDC42BPG for ontologies About GeneDecksing
|
Drugs & Compounds
for CDC42BPG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDC42BPG
10/847 HMDB Compounds for CDC42BPG (see all 847) About this table
Search CenterWatch for drugs/clinical trials and news about CDC42BPG / MRCKG
|
Transcripts
for CDC42BPG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDC42BPG gene: NM_017525.2 Unigene Cluster for CDC42BPG: CDC42 binding protein kinase gamma (DMPK-like) Hs.293590 [show with all ESTs]Unigene Representative Sequence: NM_0175254 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342711(uc001obs.4) ENST00000491280 ENST00000468512 ENST00000480767
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDC42BPG (NM_017525) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC42BPG | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CDC42BPG |
Additional cDNA sequence: AF001543.1 AF001544.1 AY648038.1 Y12337.1 4 DOTS entries: DT.428320 DT.40302887 DT.91752275 DT.95212265 24/25 AceView cDNA sequences (see all 25): AW992403 NM_017525 AY648038 AF001544 CK821112 AF001543 BE793390 BI793270 BG752641 BG678034 BQ947017 Y12337 BF991223 CK821111 BI792977 BG105639 H01451 AA809737 AW516225 BG952299 BG014499 AW814108 BF357216 BF357213
GeneLoc Exon Structure
|
Expression
for CDC42BPG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC42BPG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATTCGGA
About this image
See CDC42BPG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC42BPG
SOURCE GeneReport for Unigene cluster: Hs.293590
UniProtKB/Swiss-Prot: MRCKG_HUMAN, Q6DT37Tissue specificity: Expressed in heart and skeletal muscle
SABiosciences Custom PCR Arrays for CDC42BPG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42BPG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDC42BPG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42BPG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42BPG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPG |
Orthologs
for CDC42BPG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDC42BPG gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
47(a) |
1 ↔ 1 |
GL345031.1(1363-13844) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01014572.16 |
-- |
8(a) |
possible ortholog |
8(4015429-4121991) |
fruit fly
(Drosophila melanogaster) |
Insecta |
gek6 |
genghis khan |
33(a) |
1 → many |
2R(19979600-19986157) |
worm
(Caenorhabditis elegans) |
Secernentea |
mrck-16 |
Myotonic dystrophy-Related, Cdc42-binding Kinase h... |
34(a) |
1 → many |
V(6257384-6267174) |
ENSEMBL Gene Tree for CDC42BPG (if available)
TreeFam Gene Tree for CDC42BPG (if available) |
Paralogs
for CDC42BPG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDC42BPG gene
- DMPK2 LATS12 STK38L2 CDC42BPB2 STK382 CIT2 ROCK12 LATS22
- CDC42BPA2 ROCK22
18/20 SIMAP similar genes for CDC42BPG using alignment to 1 protein entry: MRCKG_HUMAN(see all similar genes):CDC42BPB KIN27 CDC42BPA DKFZp686P1738 PRKACA SGK2
STK38 PRKACG PRKX PRKY STK38L RPS6KB1
SGK1 SGK3 SGKL PRKACB RPS6KB2 PkB-like 1
CDC42BPG for paralogs About GeneDecksing
|
Genomic Variants
for CDC42BPG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDC42BPG (64590859 - 64612041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDC42BPG
1 CNV: 4753 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42BPG |
|
Disorders
/ Diseases
for CDC42BPG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDC42BPG for disorders About GeneDecksing
OMIM gene information: 613991
OMIM disorders: --
3  diseases for CDC42BPG: About MalaCardsmyotonic dystrophy multiple endocrine neoplasia gout
Export disorders for CDC42BPG gene to outside databases
|
Publications
for CDC42BPG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDC42BPG gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDC42BPG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of the human myotonic dystrophy kinase-related Cdc42- binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. (PubMed id 15194684)1, 2, 3, 9 Ng Y.... Leung T. (2004)
- The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PubMed id 9341881)1, 2, 3 Kedra D.... Dumanski J. (1997)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association study for serum urate concent rations and gout among African Americans identifies genomic risk loci and a nov el URAT1 loss-of-function allele. (PubMed id 21768215)1 Tin A....KAPttgen A. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1 Guru S.C....Chandrasekharappa S.C. (1997)
- Myotonic dystrophy protein kinase monoclonal antibody generation from a coiled-coil template. (PubMed id 16680721)9 Helmke S.M....Perryman M.B. (2006)
|
External Searches for CDC42BPG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDC42BPG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDC42BPG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDC42BPG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDC42BPG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDC42BPG gene:
Search GeneIP for patents involving CDC42BPG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC42BPG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPG |
|  |  |  | | | | Search ThermoFisher Antibodies for CDC42BPG |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CDC42BPG |
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