CDC42BPB Gene
protein-coding GIFtS: 56
GCID: GC14M103398
|
|
CDC42 binding protein kinase beta (DMPK-like)(Previous name: CDC42-binding protein kinase beta (DMPK-like) )
| |
Aliases
for CDC42BPB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CDC42 Binding Protein Kinase Beta (DMPK-Like)1 2 | | DMPK-Like Beta2 3 | | MRCKB1 2 | | MRCK Beta2 3 | | CDC42-Binding Protein Kinase Beta (DMPK-Like)1 2 | | EC 2.7.11.13 8 | | KIAA11241 3 | | Serine/Threonine-Protein Kinase MRCK Beta2 | | Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta2 3 | | CDC42-Binding Protein Kinase Beta3 | | Myotonic Dystrophy Protein Kinase-Like Beta2 3 | | EC 2.7.118 | | CDC42BP-Beta1 | | |
Export aliases for CDC42BPB gene to outside databasesPrevious GC identifers: GC14M100789 GC14M097214 GC14M101388 GC14M102468 GC14M083573 |
Summaries
for CDC42BPB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDC42BPB:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains aCdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closelyrelated to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that thiskinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MRCKB_HUMAN, Q9Y5S2Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in theregulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization viaphosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellaractomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A
|
Genomic Views
for CDC42BPB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC42BPB gene promoter:
AREB6 CREB AhR C/EBPbeta E2F-1 Nkx5-1 GATA-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC42BPB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42BPB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32.32CDC42BPB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M103398: view genomic region
(about GC identifiers)
Start:
|
103,398,716 bp from pter |
End:
|
103,523,799 bp from pter |
Size:
|
125,084 bases |
Orientation:
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minus strand |
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Proteins
for CDC42BPB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRCKB_HUMAN, Q9Y5S2 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase MRCK beta Size: 1711 amino acids; 194315 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-boundCDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartitecomplex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 bindingresults in activation of CDC42BPB by abolition of its negative autoregulation
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Celljunction. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at theleading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at theleading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction withcatalytically active CDC42
Sequence caution: Sequence=AAH47871.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAA86438.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for CDC42BPB:3QFV (3D)
3TKU (3D)
Secondary accessions: Q2L7A5 Q86TJ1 Q9ULU5Explore the universe of human proteins at neXtProt for CDC42BPB: NX_Q9Y5S2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5S2
4/19 DME Specific Peptides for CDC42BPB (Q9Y5S2) (see all 19)
CDC42BPB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006026.3
ENSEMBL proteins: ENSP00000355237 ENSP00000453311 ENSP00000453384
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CDC42BPB for ontologies About GeneDecksing
CDC42BPB Antibody Products:
Assay Products for CDC42BPB: |
Protein
Domains /
Families
for CDC42BPB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDC42BPB for domains About GeneDecksing
5/14 InterPro domains/families (see all 14):Graphical View of Domain Structure for InterPro Entry Q9Y5S2ProtoNet protein and cluster: Q9Y5S2 3 Blocks protein families: IPB000961 Protein kinase C-terminal domain IPB001180 Citron-like IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: MRCKB_HUMAN, Q9Y5S2Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 CNH domainSimilarity: Contains 1 CRIB domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 protein kinase domain |
Function
for CDC42BPB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRCKB_HUMAN, Q9Y5S2Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in theregulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization viaphosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellaractomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12ACatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Maintained in an inactive, closed conformation by an interaction between the kinase domain and thenegative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disruptsthis, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation bytransautophosphorylation (By similarity). Inhibited by chelerythrine chloride Genatlas biochemistry entry for CDC42BPB:CDC42-binding protein kinase beta,rat myotonic dystrophy protein kinase related (DMPK-like),beta (MRCKB),widelyexpressed,phosphorylating non muscle myosin like chain (see MYLK),a prerequisite for the activation of actin-myosincontractility,downstream effector of CDC42 in cytoskeletal reorganization
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPB |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
CDC42BPB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CDC42BPB:
|
Pathways & Interactions
for CDC42BPB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC42BPB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for CDC42BPB (Q9Y5S22, 3 ENSP000003552374) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
CDC42BPB for ontologies About GeneDecksing
|
Drugs & Compounds
for CDC42BPB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDC42BPB
10/845 HMDB Compounds for CDC42BPB (see all 845) About this table
Search CenterWatch for drugs/clinical trials and news about CDC42BPB / MRCKB
|
Transcripts
for CDC42BPB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDC42BPB gene: NM_006035.3 Unigene Cluster for CDC42BPB: CDC42 binding protein kinase beta (DMPK-like) Hs.654634 [show with all ESTs]Unigene Representative Sequence: AF1286258 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361246(uc001ymj.1 uc001ymi.1) ENST00000560492 ENST00000559790
ENST00000559245 ENST00000558867 ENST00000559043 ENST00000558321 ENST00000561271
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDC42BPB (NM_006035) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC42BPB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42BPB |
Additional cDNA sequence: AB032950.3 AF128625.1 AK058115.1 BC047871.1 BC048261.1 BC155541.1 BX248752.1 17 DOTS entries: DT.432038 DT.95113019 DT.95113018 DT.120773058 DT.100701139 DT.40310050 DT.100701676 DT.120773113 DT.75196912 DT.95113065 DT.100819448 DT.120773115 DT.75129740 DT.91737866 DT.120773096 DT.91772829 DT.99955757 24/425 AceView cDNA sequences (see all 425): BM741433 BG286876 AA324819 AL079429 AI243796 BM670466 BM931135 AI761729 BQ959960 AA350276 BM709618 BX248752 BU152842 BM724056 BM742543 BF196834 BU845217 BU687232 BG403684 BQ669224 AA350036 CB158522 AI342317 BU521334
GeneLoc Exon Structure
|
Expression
for CDC42BPB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC42BPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCCCCGT
About this image
See CDC42BPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC42BPB
SOURCE GeneReport for Unigene cluster: Hs.654634
UniProtKB/Swiss-Prot: MRCKB_HUMAN, Q9Y5S2Tissue specificity: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung
SABiosciences Custom PCR Arrays for CDC42BPB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42BPB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDC42BPB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42BPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42BPB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPB |
Orthologs
for CDC42BPB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDC42BPB gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDC42BPB1 |
CDC42 binding protein kinase beta (DMPK-like) |
77.76(n)
83.86(a) |
|
423473 XM_421380.3 XP_421380.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CDC42BPB6 |
-- |
85(a) |
1 ↔ 1 |
GL343232.1(819612-922916) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.235722 |
Xenopus laevis, Similar to CDC42 binding protein kinase more |
79.08(n) |
|
BC041741.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570447822 |
-- |
78.21(n) |
|
57044782 |
fruit fly
(Drosophila melanogaster) |
Insecta |
gek3 |
actin polymerization and/or depolymerization
protein more |
40(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
K08B12.53 |
serine/threonine-protein kinase |
37(a) |
|
V(6260624-6269785) -- |
ENSEMBL Gene Tree for CDC42BPB (if available)
TreeFam Gene Tree for CDC42BPB (if available) |
Paralogs
for CDC42BPB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDC42BPB gene
- CDC42BPG2 DMPK2 LATS12 STK38L2 STK382 CIT2 ROCK12 LATS22
- CDC42BPA2 ROCK22
18/43 SIMAP similar genes for CDC42BPB using alignment to 5 protein entries: MRCKB_HUMAN (see all proteins)
(see all similar genes):CDC42BPA DKFZp686P1738 ROCK2 ROCK1 DMPK CDC42BPG
KIN27 PRKCQ SGK1 SGK2 RPS6KA3 AKT3
PRKACG PRKX AKT2 MARK4 PRKACA PRKY
CDC42BPB for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CDC42BPB
PGOHUM00000241700 PGOHUM00000241702
|
Genomic Variants
for CDC42BPB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDC42BPB (103398716 - 103523799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CDC42BPB
2 CNVs: 4848 0180
1 Indel: 11772
Human Gene Mutation Database (HGMD): CDC42BPB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42BPB |
|
Disorders
/ Diseases
for CDC42BPB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDC42BPB for disorders About GeneDecksing
OMIM gene information: 614062
OMIM disorders: --
4  diseases for CDC42BPB: About MalaCardsmyotonic dystrophy ankylosing spondylitis spondylitis ovarian cancer
Human Genome Epidemiology (HuGE) Navigator: CDC42BPB (1 document)
Export disorders for CDC42BPB gene to outside databases
|
Publications
for CDC42BPB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDC42BPB gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with CDC42BPB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. (PubMed id 10198171)1, 2, 3, 9 Moncrieff C.L.... Johnson K.J. (1999)
- Co-crystal structures of inhibitors with MRCKI^, a key regulator of tumor cell invasion. (PubMed id 21949762)1, 2 Heikkila T....Olson M.F. (2011)
- Cdc42-dependent formation of the ZO-1/MRCKI^ complex a t the leading edge controls cell migration. (PubMed id 21240187)1, 2 Huo L....Zhang M. (2011)
- A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. (PubMed id 18854160)1, 2 Tan I....Leung T. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- Overexpression and unique rearrangement of VH2 transc ripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis pa tients. (PubMed id 20177145)1, 9 Kim Y.J....Nam C.H. (2010)
- Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
|
External Searches for CDC42BPB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDC42BPB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDC42BPB gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CDC42BPB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDC42BPB | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/cdc42bpb/ |
|
| | |
About This Section
| Patent Information for CDC42BPB gene:
Search GeneIP for patents involving CDC42BPB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC42BPB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDC42BPB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC42BPB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42BPB | | | OriGene Protein Over-expression Lysate for CDC42BPB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDC42BPB | | OriGene 3'-UTR Clone for CDC42BPB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42BPB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDC42BPB | | OriGene Custom Protein Services for CDC42BPB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC42BPB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42BPB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42BPB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC42BPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42BPB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42BPB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42BPB |
|  |  |  | | | | Search ThermoFisher Antibodies for CDC42BPB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42BPB |
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