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Aliases for CDC42BPB Gene

Aliases for CDC42BPB Gene

  • CDC42 Binding Protein Kinase Beta 2 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Beta 3 4
  • CDC42-Binding Protein Kinase Beta (DMPK-Like) 2 3
  • CDC42 Binding Protein Kinase Beta (DMPK-Like) 3 5
  • Myotonic Dystrophy Protein Kinase-Like Beta 3 4
  • DMPK-Like Beta 3 4
  • CDC42BP-Beta 3 4
  • EC 2.7.11.1 4 63
  • MRCK Beta 3 4
  • CDC42-Binding Protein Kinase Beta 4
  • EC 2.7.11 63
  • KIAA1124 4
  • MRCKB 3

External Ids for CDC42BPB Gene

Previous GeneCards Identifiers for CDC42BPB Gene

  • GC14M100789
  • GC14M097214
  • GC14M101388
  • GC14M102468
  • GC14M103398
  • GC14M083573

Summaries for CDC42BPB Gene

Entrez Gene Summary for CDC42BPB Gene

  • This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42BPB Gene

CDC42BPB (CDC42 Binding Protein Kinase Beta) is a Protein Coding gene. Diseases associated with CDC42BPB include myotonic dystrophy and lung large cell carcinoma. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.

UniProtKB/Swiss-Prot for CDC42BPB Gene

  • Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPB Gene

Genomics for CDC42BPB Gene

Regulatory Elements for CDC42BPB Gene

Enhancers for CDC42BPB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC42BPB on UCSC Golden Path with GeneCards custom track

Promoters for CDC42BPB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC42BPB on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC42BPB Gene

Chromosome:
14
Start:
102,932,379 bp from pter
End:
103,057,462 bp from pter
Size:
125,084 bases
Orientation:
Minus strand

Genomic View for CDC42BPB Gene

Genes around CDC42BPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPB Gene

Proteins for CDC42BPB Gene

  • Protein details for CDC42BPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S2-MRCKB_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK beta
    Protein Accession:
    Q9Y5S2
    Secondary Accessions:
    • A9JR72
    • Q2L7A5
    • Q86TJ1
    • Q9ULU5

    Protein attributes for CDC42BPB Gene

    Size:
    1711 amino acids
    Molecular mass:
    194315 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions (PubMed:21949762). Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393). Interacts with CPNE4 (via VWFA domain) (By similarity).
    SequenceCaution:
    • Sequence=AAH47871.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86438.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC42BPB Gene

neXtProt entry for CDC42BPB Gene

Proteomics data for CDC42BPB Gene at MOPED

Post-translational modifications for CDC42BPB Gene

  • Ubiquitination at Lys 864
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC42BPB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CDC42BPB Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5S2

UniProtKB/Swiss-Prot:

MRCKB_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 CRIB domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CDC42BPB: view

Function for CDC42BPB Gene

Molecular function for CDC42BPB Gene

GENATLAS Biochemistry:
CDC42-binding protein kinase beta,rat myotonic dystrophy protein kinase related (DMPK-like),beta (MRCKB),widely expressed,phosphorylating non muscle myosin like chain (see MYLK),a prerequisite for the activation of actin-myosin contractility,downstream effector of CDC42 in cytoskeletal reorganization
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). Inhibited by chelerythrine chloride.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.

Enzyme Numbers (IUBMB) for CDC42BPB Gene

genes like me logo Genes that share phenotypes with CDC42BPB: view

Animal Model Products

CRISPR Products

miRNA for CDC42BPB Gene

miRTarBase miRNAs that target CDC42BPB

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPB Gene

Localization for CDC42BPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPB Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42BPB Gene COMPARTMENTS Subcellular localization image for CDC42BPB gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CDC42BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005911 cell-cell junction ISS --
genes like me logo Genes that share ontologies with CDC42BPB: view

Pathways & Interactions for CDC42BPB Gene

SuperPathways for CDC42BPB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC42BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007165 signal transduction TAS 9418861
GO:0031032 actomyosin structure organization IEA,IMP 18854160
genes like me logo Genes that share ontologies with CDC42BPB: view

No data available for Pathways by source and SIGNOR curated interactions for CDC42BPB Gene

Drugs & Compounds for CDC42BPB Gene

(2) Drugs for CDC42BPB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(4) Additional Compounds for CDC42BPB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CDC42BPB: view

Transcripts for CDC42BPB Gene

Unigene Clusters for CDC42BPB Gene

CDC42 binding protein kinase beta (DMPK-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPB Gene

No ASD Table

Relevant External Links for CDC42BPB Gene

GeneLoc Exon Structure for
CDC42BPB
ECgene alternative splicing isoforms for
CDC42BPB

Expression for CDC42BPB Gene

mRNA expression in normal human tissues for CDC42BPB Gene

Protein differential expression in normal tissues from HIPED for CDC42BPB Gene

This gene is overexpressed in Heart (15.1) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42BPB Gene



SOURCE GeneReport for Unigene cluster for CDC42BPB Gene Hs.654634

mRNA Expression by UniProt/SwissProt for CDC42BPB Gene

Q9Y5S2-MRCKB_HUMAN
Tissue specificity: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
genes like me logo Genes that share expression patterns with CDC42BPB: view

Protein tissue co-expression partners for CDC42BPB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDC42BPB Gene

Orthologs for CDC42BPB Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC42BPB 35
  • 85.56 (n)
  • 90.74 (a)
CDC42BPB 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42BPB 35
  • 88.35 (n)
  • 92.81 (a)
CDC42BPB 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42bpb 35
  • 85.86 (n)
  • 91.99 (a)
Cdc42bpb 16
Cdc42bpb 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPB 35
  • 99.78 (n)
  • 99.82 (a)
CDC42BPB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42bpb 35
  • 86.56 (n)
  • 92.17 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC42BPB 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPB 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC42BPB 35
  • 77.88 (n)
  • 83.92 (a)
CDC42BPB 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42BPB 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42bpb 35
  • 73.95 (n)
  • 79.89 (a)
Str.7145 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23572 35
zebrafish
(Danio rerio)
Actinopterygii cdc42bpb 35
  • 71.1 (n)
  • 74.26 (a)
cdc42bpb 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8420 35
fruit fly
(Drosophila melanogaster)
Insecta gek 37
  • 40 (a)
gek 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08B12.5 37
  • 37 (a)
mrck-1 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 36
  • 49 (a)
OneToMany
Species with no ortholog for CDC42BPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42BPB Gene

ENSEMBL:
Gene Tree for CDC42BPB (if available)
TreeFam:
Gene Tree for CDC42BPB (if available)

Paralogs for CDC42BPB Gene

Paralogs for CDC42BPB Gene

Pseudogenes.org Pseudogenes for CDC42BPB Gene

genes like me logo Genes that share paralogs with CDC42BPB: view

Variants for CDC42BPB Gene

Sequence variations from dbSNP and Humsavar for CDC42BPB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34822377 - 102,950,546(-) GCCCA(A/G)TACCT nc-transcript-variant, reference, missense
VAR_040834 A breast infiltrating ductal carcinoma sample
rs36001612 - 102,972,139(+) TCAAC(C/T)GCTCT nc-transcript-variant, reference, missense
rs55948035 - 102,968,700(+) CTCCC(C/T)GGCCT nc-transcript-variant, reference, missense
VAR_040837 A colorectal adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPB Gene

Variant ID Type Subtype PubMed ID
nsv483032 CNV Gain 15286789
nsv509552 CNV Insertion 20534489
dgv1985n71 CNV Loss 21882294
nsv902263 CNV Loss 21882294
nsv9167 CNV Gain 18304495
esv269754 CNV Insertion 20981092
nsv832882 CNV Loss 17160897
esv2749154 CNV Deletion 23290073
esv2671530 CNV Deletion 23128226
esv2749155 CNV Deletion 23290073
esv2749156 CNV Deletion 23290073
nsv85067 CNV Loss 16902084
esv2749157 CNV Deletion 23290073
nsv1431 CNV Insertion 18451855
nsv902264 CNV Loss 21882294

Variation tolerance for CDC42BPB Gene

Residual Variation Intolerance Score: 0.964% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC42BPB Gene

HapMap Linkage Disequilibrium report
CDC42BPB
Human Gene Mutation Database (HGMD)
CDC42BPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPB Gene

Disorders for CDC42BPB Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDC42BPB Gene - From: GeneCards

Disorder Aliases PubMed IDs
myotonic dystrophy
  • curschmann-batten-steinert syndrome
lung large cell carcinoma
  • large cell carcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDC42BPB

Genetic Association Database (GAD)
CDC42BPB
Human Genome Epidemiology (HuGE) Navigator
CDC42BPB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC42BPB
genes like me logo Genes that share disorders with CDC42BPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC42BPB Gene

Publications for CDC42BPB Gene

  1. Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. (PMID: 10198171) Moncrieff C.L. … Johnson K.J. (Genomics 1999) 2 3 4 23 67
  2. Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients. (PMID: 20177145) Kim Y.J. … Nam C.H. (Exp. Mol. Med. 2010) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CDC42BPB Gene

Sources for CDC42BPB Gene

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