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Aliases for CDC42BPA Gene

Aliases for CDC42BPA Gene

  • CDC42 Binding Protein Kinase Alpha 2 3 5
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha 3 4
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • DMPK-Like Alpha 3 4
  • EC 2.7.11.1 4 61
  • MRCK Alpha 3 4
  • Ser-Thr Protein Kinase Related To The Myotonic Dystrophy Protein Kinase 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha 3
  • Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase 2
  • CDC42-Binding Protein Kinase Alpha (DMPK-Like) 2
  • CDC42 Binding Protein Kinase Alpha (DMPK-Like) 3
  • Serine/Threonine-Protein Kinase MRCK Alpha 3
  • CDC42-Binding Protein Kinase Alpha 4
  • CDC42 Binidng Protein Kinase Beta 3
  • Ser-Thr Protein Kinase PK428 3
  • EC 2.7.11 61
  • KIAA0451 4
  • MRCKA 3
  • PK428 3
  • MRCK 3

External Ids for CDC42BPA Gene

Previous GeneCards Identifiers for CDC42BPA Gene

  • GC00U990464
  • GC01M223045
  • GC01M223563
  • GC01M224152
  • GC01M224154
  • GC01M223484
  • GC01M225244
  • GC01M227177
  • GC01M197694

Summaries for CDC42BPA Gene

Entrez Gene Summary for CDC42BPA Gene

  • The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42BPA Gene

CDC42BPA (CDC42 Binding Protein Kinase Alpha) is a Protein Coding gene. Diseases associated with CDC42BPA include Myotonic Dystrophy. Among its related pathways are G-protein signaling RAC1 in cellular process and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is CDC42BPB.

UniProtKB/Swiss-Prot for CDC42BPA Gene

  • Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.

Gene Wiki entry for CDC42BPA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPA Gene

Genomics for CDC42BPA Gene

Regulatory Elements for CDC42BPA Gene

Enhancers for CDC42BPA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G227427 1.3 Ensembl ENCODE dbSUPER 19.3 -110.9 -110860 3.5 ELF3 SOX13 PKNOX1 NFIB TAL1 JUN CEBPG TEAD3 FOSL1 TCF12 CDC42BPA LINC01641 COQ8A SNAP47 ENSG00000269934 RPS18P3 NUCKS1P1
GH01G227343 1.2 ENCODE dbSUPER 18.6 -25.5 -25519 1.5 HDAC1 ZSCAN4 FEZF1 RAD21 CHAMP1 RFX5 EGR1 ZNF366 FOS EGR2 CDC42BPA LINC01641
GH01G227314 1.4 ENCODE dbSUPER 15.5 +1.5 1531 5.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF548 CICP26 CDC42BPA ENSG00000269890 GC01M227291
GH01G227225 0.9 Ensembl ENCODE 21.9 +92.7 92652 1.4 HDAC1 SMARCE1 PKNOX1 STAT1 KLF1 L3MBTL2 JUN CEBPB JUND SMARCA4 CDC42BPA COQ8A LOC100418874 ENSG00000228625
GH01G227431 1.6 Ensembl ENCODE dbSUPER 10.8 -113.6 -113556 1.5 PKNOX1 FOXA2 CREB3L1 ARNT ZNF2 ZNF766 ZNF416 FOS KLF13 MCM3 C1orf35 CICP26 ENSG00000269890 CDC42BPA JMJD4 LINC01641 RPS18P3 BTF3P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC42BPA on UCSC Golden Path with GeneCards custom track

Promoters for CDC42BPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021193 1692 5201 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF548

Genomic Location for CDC42BPA Gene

Chromosome:
1
Start:
226,989,858 bp from pter
End:
227,318,492 bp from pter
Size:
328,635 bases
Orientation:
Minus strand

Genomic View for CDC42BPA Gene

Genes around CDC42BPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPA Gene

Proteins for CDC42BPA Gene

  • Protein details for CDC42BPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT25-MRCKA_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK alpha
    Protein Accession:
    Q5VT25
    Secondary Accessions:
    • O75039
    • Q59GZ1
    • Q5H9N9
    • Q5T797
    • Q5VT26
    • Q5VT27
    • Q86XX2
    • Q86XX3
    • Q99646

    Protein attributes for CDC42BPA Gene

    Size:
    1732 amino acids
    Molecular mass:
    197307 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation.
    SequenceCaution:
    • Sequence=BAD92205.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC42BPA Gene

neXtProt entry for CDC42BPA Gene

Selected DME Specific Peptides for CDC42BPA Gene

Q5VT25:
  • DTSNFDVDD
  • DIKPDNI
  • CDWWSLG
  • KVIGRGAF
  • HRDIKPDN
  • RLADFGSCL
  • PLKKVRPLN
  • GTPDYISPE
  • RLIYFKNK
  • GETPFYAESLVETYGKIMNH
  • SPTDTSNFD
  • VAVGTPDYISPEIL
  • LHYAFQD
  • AFSGHHLPFVGFTYTS
  • CFREERDVLV
  • GGDLLTLLS
  • RGYLQALA
  • LYLVMDY

Post-translational modifications for CDC42BPA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDC42BPA Gene

Graphical View of Domain Structure for InterPro Entry

Q5VT25

UniProtKB/Swiss-Prot:

MRCKA_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
genes like me logo Genes that share domains with CDC42BPA: view

Function for CDC42BPA Gene

Molecular function for CDC42BPA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
UniProtKB/Swiss-Prot Induction:
Regulated by cellular iron levels.

Enzyme Numbers (IUBMB) for CDC42BPA Gene

Gene Ontology (GO) - Molecular Function for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9092543
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9092543
GO:0005515 protein binding IPI 9418861
GO:0005524 ATP binding IEA,IDA 9092543
genes like me logo Genes that share ontologies with CDC42BPA: view
genes like me logo Genes that share phenotypes with CDC42BPA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPA Gene

Localization for CDC42BPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPA Gene

Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC42BPA gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 3
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005911 cell-cell junction ISS --
GO:0031252 cell leading edge ISS --
GO:0042641 actomyosin IDA 18854160
genes like me logo Genes that share ontologies with CDC42BPA: view

Pathways & Interactions for CDC42BPA Gene

genes like me logo Genes that share pathways with CDC42BPA: view

Pathways by source for CDC42BPA Gene

1 BioSystems pathway for CDC42BPA Gene
1 GeneGo (Thomson Reuters) pathway for CDC42BPA Gene
1 Qiagen pathway for CDC42BPA Gene

SIGNOR curated interactions for CDC42BPA Gene

Activates:

Gene Ontology (GO) - Biological Process for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 9092543
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IMP 18854160
GO:0031032 actomyosin structure organization IMP 18854160
GO:0031532 actin cytoskeleton reorganization IDA 9418861
genes like me logo Genes that share ontologies with CDC42BPA: view

Drugs & Compounds for CDC42BPA Gene

(4) Drugs for CDC42BPA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for CDC42BPA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CDC42BPA: view

Transcripts for CDC42BPA Gene

Unigene Clusters for CDC42BPA Gene

CDC42 binding protein kinase alpha (DMPK-like):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6:
SP7:

ExUns: 23b ^ 24 ^ 25a · 25b
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for CDC42BPA Gene

GeneLoc Exon Structure for
CDC42BPA
ECgene alternative splicing isoforms for
CDC42BPA

Expression for CDC42BPA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC42BPA Gene

Protein differential expression in normal tissues from HIPED for CDC42BPA Gene

This gene is overexpressed in Breast (39.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC42BPA Gene



Protein tissue co-expression partners for CDC42BPA Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC42BPA Gene:

CDC42BPA

SOURCE GeneReport for Unigene cluster for CDC42BPA Gene:

Hs.35433

mRNA Expression by UniProt/SwissProt for CDC42BPA Gene:

Q5VT25-MRCKA_HUMAN
Tissue specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.

Evidence on tissue expression from TISSUES for CDC42BPA Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CDC42BPA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC42BPA Gene

Orthologs for CDC42BPA Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC42BPA 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPA 34
  • 92.52 (n)
dog
(Canis familiaris)
Mammalia CDC42BPA 34 35
  • 90.79 (n)
mouse
(Mus musculus)
Mammalia Cdc42bpa 34 16 35
  • 90.73 (n)
rat
(Rattus norvegicus)
Mammalia Cdc42bpa 34
  • 90.52 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC42BPA 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPA 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC42BPA 34 35
  • 82.12 (n)
lizard
(Anolis carolinensis)
Reptilia CDC42BPA 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42bpa 34
  • 72.21 (n)
zebrafish
(Danio rerio)
Actinopterygii CDC42BPA (2 of 2) 35
  • 73 (a)
OneToMany
CDC42BPA (1 of 2) 35
  • 72 (a)
OneToMany
si:ch211-89p3.3 34
  • 68.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012090 34
  • 50.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta gek 34 35
  • 49.2 (n)
worm
(Caenorhabditis elegans)
Secernentea mrck-1 34 35
  • 52.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 35
  • 51 (a)
OneToMany
Species where no ortholog for CDC42BPA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42BPA Gene

ENSEMBL:
Gene Tree for CDC42BPA (if available)
TreeFam:
Gene Tree for CDC42BPA (if available)

Paralogs for CDC42BPA Gene

Paralogs for CDC42BPA Gene

(63) SIMAP similar genes for CDC42BPA Gene using alignment to 8 proteins: