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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC42BPA Gene

protein-coding   GIFtS: 62
GCID: GC01M227177

CDC42 Binding Protein Kinase Alpha (DMPK-Like)

(Previous name: CDC42-binding protein kinase alpha (DMPK-like))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDC42 Binding Protein Kinase Alpha (DMPK-Like)1 2     MRCK2
CDC42-Binding Protein Kinase Alpha (DMPK-Like)1 2     CDC42 Binidng Protein Kinase Beta2
Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha2 3     Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha2
Myotonic Dystrophy Protein Kinase-Like Alpha2 3     Ser-Thr Protein Kinase PK4282
DMPK-Like Alpha2 3     Ser-Thr Protein Kinase Related To The Myotonic Dystrophy Protein Kinase2
MRCK Alpha2 3     Serine/Threonine-Protein Kinase MRCK Alpha2
EC 2.7.11.13 8     KIAA04513
MRCKA2 5     CDC42-Binding Protein Kinase Alpha3
PK4282 5     EC 2.7.118
Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase1     

External Ids:    HGNC: 17371   Entrez Gene: 84762   Ensembl: ENSG000001437767   OMIM: 6034125   UniProtKB: Q5VT253   

Export aliases for CDC42BPA gene to outside databases

Previous GC identifers: GC00U990464 GC01M223045 GC01M223563 GC01M224152 GC01M224154 GC01M223484 GC01M225244 GC01M197694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC42BPA Gene:
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains
multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase
(DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It
may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting
cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the
full-length nature of two of them has been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC42BPA Gene: 
CDC42BPA (CDC42 binding protein kinase alpha (DMPK-like)) is a protein-coding gene. Diseases associated with CDC42BPA include myotonic dystrophy, and endotheliitis, and among its related super-pathways are Actin Nucleation and Branching and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include phospholipid binding and identical protein binding. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: MRCKA_HUMAN, Q5VT25
Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in
the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via
phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar
actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and
LIMK2. May play a role in TFRC-mediated iron uptake

Gene Wiki entry for CDC42BPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC42BPA gene promoter:
         Pbx1a   AP-1   POU6F1 (c2)   MEF-2A   S8   Zic1   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC42BPA promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC42BPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42BPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.11

CDC42BPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42BPA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M227177:  view genomic region     (about GC identifiers)

Start:
227,177,566 bp from pter      End:
227,506,175 bp from pter
Size:
328,610 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRCKA_HUMAN, Q5VT25 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MRCK alpha  
Size: 1732 amino acids; 197307 Da
Cofactor: Magnesium
Subunit: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not
GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter
connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative
autoregulation
Subcellular location: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates
along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain
dependent (By similarity)
Sequence caution: Sequence=BAD92205.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O75039 Q59GZ1 Q5H9N9 Q5T797 Q5VT26 Q5VT27 Q86XX2 Q86XX3 Q99646
Alternative splicing: 6 isoforms:  Q5VT25-1   Q5VT25-2   Q5VT25-3   Q5VT25-4   Q5VT25-5   Q5VT25-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC42BPA: NX_Q5VT25

Explore proteomics data for CDC42BPA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VT25

  • 4/18 DME Specific Peptides for CDC42BPA (Q5VT25) (see all 18)
     DIKPDNI  CDWWSLG  LYLVMDY  LHYAFQD 

    CDC42BPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC42BPA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003598.2  NP_055641.3  

    ENSEMBL proteins: 
     ENSP00000355729   ENSP00000355731   ENSP00000415388   ENSP00000401051   ENSP00000355727  
     ENSP00000407120   ENSP00000408165   ENSP00000335341   ENSP00000355728   ENSP00000355726  
     ENSP00000443275  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005911cell-cell junction ISS--
    GO:0031252cell leading edge ISS--
    GO:0042641actomyosin IDA18854160

    CDC42BPA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC42 binding protein kinase alpha (DMPK-like) 
    GEK subfamily
    Other AGC kinases

    5/13 InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR014930 Myotonic_dystrophy_kinase_coil
     IPR026611 Ser/Thr_kinase_MRCK
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5VT25

    ProtoNet protein and cluster: Q5VT25

    4 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001180 Citron-like
    IPB003345 M protein repeat
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: MRCKA_HUMAN, Q5VT25
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 CRIB domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    CDC42BPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRCKA_HUMAN, Q5VT25
    Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in
    the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via
    phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar
    actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and
    LIMK2. May play a role in TFRC-mediated iron uptake
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Maintained in an inactive, closed conformation by an interaction between the kinase domain and
    the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site
    disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by
    transautophosphorylation. Inhibited by chelerythrine chloride
    Induction: Regulated by cellular iron levels

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA9092543
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11340065
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
         
    CDC42BPA for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDC42BPA:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Increased colony dispersion (i 
     Increased mitotic index 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC42BPA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    2Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    3CDC42 signaling events
    CDC42 signaling events0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CDC42BPA
        Cytoskeleton remodeling CDC42 in cellular processes

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDC42BPA
        CDC42 Pathway

    1 GeneGo (Thomson Reuters) Pathway for CDC42BPA
        Cytoskeleton remodeling CDC42 in cellular processes

    1 BioSystems Pathway for CDC42BPA
        CDC42 signaling events



    CDC42BPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC42BPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for CDC42BPA (Q5VT251, 3 ENSP000003557314) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609531, 3, ENSP000003144584EBI-689171,EBI-81752 I2D: score=4 STRING: ENSP00000314458
    LIMK1P536673, ENSP000003367404I2D: score=2 STRING: ENSP00000336740
    MYL12AP191053, ENSP000002176524I2D: score=2 STRING: ENSP00000217652
    MYL2P109163, ENSP000002288414I2D: score=1 STRING: ENSP00000228841
    MYO18AQ926143, ENSP000003462914I2D: score=1 STRING: ENSP00000346291
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0006468protein phosphorylation IDA9092543
    GO:0007097nuclear migration IEA--
    GO:0016477cell migration IMP18854160
    GO:0031032actomyosin structure organization IMP18854160

    CDC42BPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC42BPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDC42BPA (MRCKA)

    10/845 HMDB Compounds for CDC42BPA (see all 845)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    3 Novoseek inferred chemical compound relationships for CDC42BPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actomyosin 71.6 2 18854160 (2)
    threonine 56.8 6 10947843 (2), 9092543 (1), 11283256 (1), 20188707 (1) (see all 5)
    serine 33.1 4 9092543 (1), 12568720 (1), 11283256 (1), 20188707 (1)

    Search CenterWatch for drugs/clinical trials and news about CDC42BPA / MRCKA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC42BPA gene (2 alternative transcripts): 
    NM_003607.3  NM_014826.4  

    Unigene Cluster for CDC42BPA:

    CDC42 binding protein kinase alpha (DMPK-like)
    Hs.35433  [show with all ESTs]
    Unigene Representative Sequence: NM_003607
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366767 ENST00000366769(uc001hqr.3 uc001hqs.3 uc009xes.3 uc010pvs.2)
    ENST00000448940 ENST00000442054(uc001hqu.1) ENST00000366765 ENST00000429440(uc001hqt.2)
    ENST00000441725 ENST00000488131 ENST00000466538 ENST00000478573 ENST00000462553
    ENST00000334218(uc001hqp.3) ENST00000366766(uc001hqq.3) ENST00000366764
    ENST00000535525
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    Additional mRNA sequence: 

    AB007920.2 AB208968.1 AF250871.1 AJ518975.1 AJ518976.1 AK027000.1 AY166586.1 BC008677.1 
    BC038993.1 BC050335.1 BC127831.1 BC136333.1 BX648219.1 BX648693.1 CR933723.1 U59305.1 

    19 DOTS entries:

    DT.100024485  DT.100652651  DT.97841269  DT.95171204  DT.92028666  DT.416082  DT.97838617  DT.121429151 
    DT.202849  DT.91750831  DT.95332321  DT.92026608  DT.97784015  DT.100024487  DT.91645445  DT.91678933 
    DT.121429082  DT.75105973  DT.95153302 

    24/237 AceView cDNA sequences (see all 237):

    AL603236 BC050335 BQ576111 AJ518975 C00228 T17154 BM053102 AI214754 
    BM973855 AA400909 BF590033 BM552998 AA777833 BQ876403 BM718913 AF250871 
    BF941979 BE049337 AI337863 C01149 BF475600 AI699102 BC008677 BU170991 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPA (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
    SP1:                                            -     -                                                                                         -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                                                            -     -     -   

    ExUns: 23b ^ 24 ^ 25a · 25b
    SP1:  -                     
    SP2:                        
    SP3:  -                     
    SP4:                        
    SP5:  -                     


    ECgene alternative splicing isoforms for CDC42BPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC42BPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGTGTG
    CDC42BPA Expression
    About this image


    See CDC42BPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC42BPA

    SOURCE GeneReport for Unigene cluster: Hs.35433

    UniProtKB/Swiss-Prot: MRCKA_HUMAN, Q5VT25
    Tissue specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no
    expression in the lung and liver

        SABiosciences Expression via Pathway-Focused PCR Array including CDC42BPA: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC42BPA gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc42bpa1 , 5 CDC42 binding protein kinase alpha1, 5 90.73(n)1
    96.1(a)1
      1 (84.01 cM)5
    2267511  NM_001033285.11  NP_001028457.11 
     1799604725 
    chicken
    (Gallus gallus)
    Aves CDC42BPA1 CDC42 binding protein kinase alpha (DMPK-like) 82.12(n)
    88.24(a)
      416746  NM_001199443.1  NP_001186372.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC42BPA6
    CDC42 binding protein kinase alpha (DMPK-like)
    85(a)
    1 ↔ 1
    1(250767844-251002990)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-89p3.31 si:ch211-89p3.3 68.56(n)
    74.18(a)
      566003  NM_001045094.1  NP_001038559.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gek1 genghis khan 51.25(n)
    47.35(a)
      37858  NM_079113.2  NP_523837.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mrck-11 Protein MRCK-1 52.15(n)
    44.57(a)
      179013  NM_072198.4  NP_504599.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBK16
    Serine/threonine protein kinase of the the RAM sig...
    23(a)
    1 → many
    XIV(332597-334867)


    ENSEMBL Gene Tree for CDC42BPA (if available)
    TreeFam Gene Tree for CDC42BPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC42BPA gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    ROCK12  LATS22  ROCK22  
    18/63 SIMAP similar genes for CDC42BPA using alignment to 8 protein entries:     MRCKA_HUMAN (see all proteins) (see all similar genes):
    DKFZp686P1738    CDC42BPB    RPS6KA1    RPS6KA5    DMPK    RPS6KA3
    RPS6KA2    STK32A    PRKCE    CDC42BPG    KIN27    NEK3
    PRKCZ    SGK3    SGK2    BRAF    PRKCH    PRKACA

    CDC42BPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7304 SNPs in CDC42BPA are shown (see all 7304)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408304
    A lung neuroendocrine carcinoma sample4--see VAR_0408302 E K mis40--------
    VAR_0455854
    ----see VAR_0455852 A T mis40--------
    VAR_0408334
    ----see VAR_0408332 I K mis40--------
    VAR_0455864
    ----see VAR_0455862 R H mis40--------
    rs105394321,2
    C--197905731(+) CACAC-/AC    
       AT
    /AT
    ACACA
    2 -- int10--------
    rs1163937261,2
    C,F--227177069(+) GAACCG/AGAAGT 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs37684211,2
    C,F,H--227177193(+) AGTCCG/ATCTTG 2 -- ds500111Minor allele frequency- A:0.17EA NA WA 1994
    rs37684221,2
    C,F,A,H--227177225(+) CTGCTC/TCCACA 2 -- ds500112Minor allele frequency- T:0.15EA NA NS WA 2336
    rs1906657811,2
    --227177256(+) CAGGAA/GACCTC 2 -- ds50010--------
    rs795334281,2
    --227177289(+) TGGACC/TGAAGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CDC42BPA (227177566 - 227427566 bp, first 250kb of CDC42BPA)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for CDC42BPA (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1982712CNV Deletion18987734
    esv2668951CNV Deletion23128226
    esv2724173CNV Deletion23290073
    esv2677762CNV Deletion23128226
    esv2565209CNV Deletion19546169
    esv2724184CNV Deletion23290073
    esv2261733CNV Deletion18987734
    esv2724162CNV Deletion23290073
    esv2476939CNV Deletion19546169
    esv4979CNV Deletion18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603412    OMIM disorders: --

    2 diseases for CDC42BPA:    About MalaCards
    myotonic dystrophy    endotheliitis


    CDC42BPA for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CDC42BPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myotonic dystrophy 89.2 23 20188990 (2), 12568720 (2), 11283256 (2), 11340065 (2) (see all 15)

    Genetic Association Database (GAD): CDC42BPA
    Human Genome Epidemiology (HuGE) Navigator: CDC42BPA (1 document)

    Export disorders for CDC42BPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC42BPA gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CDC42BPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PubMed id 11283256)1, 2, 9 Tan I.... Leung T. (2001)
    2. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. (PubMed id 18854160)1, 2, 9 Tan I....Leung T. (2008)
    3. Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. (PubMed id 9092543)1, 2, 9 Zhao Y.... Kraft A.S. (1997)
    4. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. (PubMed id 15723050)1, 2, 9 Wilkinson S.... Marshall C.J. (2005)
    5. Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. (PubMed id 12568720)1, 2, 9 Tan I....Leung T. (2003)
    6. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PubMed id 11340065)1, 2, 9 Sumi T....Nakamura T. (2001)
    7. Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake. (PubMed id 20188707)1, 2, 9 Cmejla R....Vyoral D. (2010)
    8. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PubMed id 11399775)1, 2, 9 Tan I.... Leung T. (2001)
    9. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. (PubMed id 21457715)1, 2 Tan I.... Leung T. (2011)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8476 HGNC: 1737 AceView: CDC42BPA Ensembl:ENSG00000143776 euGenes: HUgn8476
    ECgene: CDC42BPA H-InvDB: CDC42BPA

    (According to HUGE)
    About This Section
    HUGE: KIAA0451

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC42BPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC42BPA gene:
    Search GeneIP for patents involving CDC42BPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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