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Aliases for CDC42BPA Gene

Aliases for CDC42BPA Gene

  • CDC42 Binding Protein Kinase Alpha (DMPK-Like) 2 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha 3 4
  • CDC42-Binding Protein Kinase Alpha (DMPK-Like) 2 3
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • DMPK-Like Alpha 3 4
  • EC 2.7.11.1 4 63
  • MRCK Alpha 3 4
  • MRCKA 3 6
  • PK428 3 6
  • Ser-Thr Protein Kinase Related To The Myotonic Dystrophy Protein Kinase 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha 3
  • Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase 2
  • Serine/Threonine-Protein Kinase MRCK Alpha 3
  • CDC42-Binding Protein Kinase Alpha 4
  • CDC42 Binidng Protein Kinase Beta 3
  • Ser-Thr Protein Kinase PK428 3
  • EC 2.7.11 63
  • KIAA0451 4
  • MRCK 3

External Ids for CDC42BPA Gene

Previous GeneCards Identifiers for CDC42BPA Gene

  • GC00U990464
  • GC01M223045
  • GC01M223563
  • GC01M224152
  • GC01M224154
  • GC01M223484
  • GC01M225244
  • GC01M227177
  • GC01M197694

Summaries for CDC42BPA Gene

Entrez Gene Summary for CDC42BPA Gene

  • The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42BPA Gene

CDC42BPA (CDC42 Binding Protein Kinase Alpha (DMPK-Like)) is a Protein Coding gene. Diseases associated with CDC42BPA include myotonic dystrophy. Among its related pathways are Actin Nucleation by ARP-WASP Complex and CDC42 signaling events. GO annotations related to this gene include identical protein binding and phospholipid binding. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for CDC42BPA Gene

  • Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.

Gene Wiki entry for CDC42BPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPA Gene

Genomics for CDC42BPA Gene

Regulatory Elements for CDC42BPA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC42BPA Gene

Start:
226,989,865 bp from pter
End:
227,318,492 bp from pter
Size:
328,628 bases
Orientation:
Minus strand

Genomic View for CDC42BPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC42BPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPA Gene

Proteins for CDC42BPA Gene

  • Protein details for CDC42BPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT25-MRCKA_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK alpha
    Protein Accession:
    Q5VT25
    Secondary Accessions:
    • O75039
    • Q59GZ1
    • Q5H9N9
    • Q5T797
    • Q5VT26
    • Q5VT27
    • Q86XX2
    • Q86XX3
    • Q99646

    Protein attributes for CDC42BPA Gene

    Size:
    1732 amino acids
    Molecular mass:
    197307 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation.
    SequenceCaution:
    • Sequence=BAD92205.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC42BPA Gene

neXtProt entry for CDC42BPA Gene

Proteomics data for CDC42BPA Gene at MOPED

Post-translational modifications for CDC42BPA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for CDC42BPA Gene

Graphical View of Domain Structure for InterPro Entry

Q5VT25

UniProtKB/Swiss-Prot:

MRCKA_HUMAN :
  • Q5VT25
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 CRIB domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CDC42BPA: view

Function for CDC42BPA Gene

Molecular function for CDC42BPA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
UniProtKB/Swiss-Prot Induction:
Regulated by cellular iron levels.

Enzyme Numbers (IUBMB) for CDC42BPA Gene

Gene Ontology (GO) - Molecular Function for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9092543
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11340065
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10644344
genes like me logo Genes that share ontologies with CDC42BPA: view
genes like me logo Genes that share phenotypes with CDC42BPA: view

Animal Model Products

CRISPR Products

miRNA for CDC42BPA Gene

miRTarBase miRNAs that target CDC42BPA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42BPA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC42BPA Gene

Localization for CDC42BPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPA Gene

Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42BPA Gene COMPARTMENTS Subcellular localization image for CDC42BPA gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005911 cell-cell junction ISS --
GO:0031252 cell leading edge ISS --
GO:0042641 actomyosin IDA 18854160
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CDC42BPA: view

Pathways for CDC42BPA Gene

genes like me logo Genes that share pathways with CDC42BPA: view

Pathways by source for CDC42BPA Gene

1 Qiagen pathway for CDC42BPA Gene
1 BioSystems pathway for CDC42BPA Gene
1 GeneGo (Thomson Reuters) pathway for CDC42BPA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006468 protein phosphorylation IDA 9092543
GO:0007097 nuclear migration IEA --
GO:0016477 cell migration IMP 18854160
GO:0031032 actomyosin structure organization IMP 18854160
genes like me logo Genes that share ontologies with CDC42BPA: view

Compounds for CDC42BPA Gene

(845) HMDB Compounds for CDC42BPA Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available

(3) Novoseek inferred chemical compound relationships for CDC42BPA Gene

Compound -log(P) Hits PubMed IDs
actomyosin 71.6 2
threonine 56.8 6
serine 33.1 4
genes like me logo Genes that share compounds with CDC42BPA: view

Transcripts for CDC42BPA Gene

Unigene Clusters for CDC42BPA Gene

CDC42 binding protein kinase alpha (DMPK-like):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC42BPA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6:
SP7:

ExUns: 23b ^ 24 ^ 25a · 25b
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for CDC42BPA Gene

GeneLoc Exon Structure for
CDC42BPA
ECgene alternative splicing isoforms for
CDC42BPA

Expression for CDC42BPA Gene

mRNA expression in normal human tissues for CDC42BPA Gene

Protein differential expression in normal tissues for CDC42BPA Gene

This gene is overexpressed in Breast (39.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42BPA Gene

SOURCE GeneReport for Unigene cluster for CDC42BPA Gene Hs.35433

mRNA Expression by UniProt/SwissProt for CDC42BPA Gene

Q5VT25-MRCKA_HUMAN
Tissue specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
genes like me logo Genes that share expressions with CDC42BPA: view

Expression partners for CDC42BPA Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDC42BPA Gene

Orthologs for CDC42BPA Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPA Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CDC42BPA 35
  • 90.79 (n)
  • 95.7 (a)
CDC42BPA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc42bpa 35
  • 90.73 (n)
  • 96.1 (a)
Cdc42bpa 16
Cdc42bpa 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPA 35
  • 92.52 (n)
  • 91.42 (a)
rat
(Rattus norvegicus)
Mammalia Cdc42bpa 35
  • 90.52 (n)
  • 95.93 (a)
cow
(Bos Taurus)
Mammalia CDC42BPA 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC42BPA 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPA 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC42BPA 35
  • 82.12 (n)
  • 88.24 (a)
CDC42BPA 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42BPA 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42bpa 35
  • 72.21 (n)
  • 80.48 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-89p3.3 35
  • 68.65 (n)
  • 74.4 (a)
CDC42BPA (1 of 2) 36
  • 72 (a)
OneToMany
CDC42BPA (2 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012090 35
  • 50.51 (n)
  • 50.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta gek 35
  • 49.2 (n)
  • 42.63 (a)
gek 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrck-1 35
  • 52.28 (n)
  • 44.86 (a)
mrck-1 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 36
  • 51 (a)
OneToMany
Species with no ortholog for CDC42BPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42BPA Gene

ENSEMBL:
Gene Tree for CDC42BPA (if available)
TreeFam:
Gene Tree for CDC42BPA (if available)

Paralogs for CDC42BPA Gene

Paralogs for CDC42BPA Gene

genes like me logo Genes that share paralogs with CDC42BPA: view

Variants for CDC42BPA Gene

Sequence variations from dbSNP and Humsavar for CDC42BPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1186 -- 226,990,030(+) TCTTA(A/T)AAAGT utr-variant-3-prime
rs1483 -- 227,177,940(+) attta(A/G)ttttt intron-variant
rs15425 -- 226,993,777(-) ATCCT(C/T)ATGAA utr-variant-3-prime
rs477162 -- 227,119,754(+) TTATA(C/T)AAGAT intron-variant
rs477373 -- 227,108,381(+) tcatt(A/G)atttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPA Gene

Variant ID Type Subtype PubMed ID
dgv535n71 CNV Loss 21882294
nsv520923 CNV Loss 19592680
esv2724162 CNV Deletion 23290073
nsv832792 CNV Loss 17160897
dgv536n71 CNV Loss 21882294
nsv468227 CNV Loss 19166990
esv2668013 CNV Deletion 23128226
nsv522990 CNV Loss 19592680
esv33574 CNV Loss 17666407
esv2724173 CNV Deletion 23290073
nsv873242 CNV Loss 21882294
esv2668951 CNV Deletion 23128226
esv22606 CNV Loss 19812545
nsv522490 CNV Loss 19592680
esv2476939 CNV Deletion 19546169
esv2261733 CNV Deletion 18987734
esv2677762 CNV Deletion 23128226
esv273315 CNV Insertion 20981092
esv268982 CNV Insertion 20981092
nsv508063 CNV Loss 20534489
esv1982712 CNV Deletion 18987734
esv2628592 CNV Deletion 19546169
esv4979 CNV Deletion 18987735
esv2724184 CNV Deletion 23290073
esv2565209 CNV Deletion 19546169
esv274526 CNV Insertion 20981092
esv271501 CNV Insertion 20981092

Relevant External Links for CDC42BPA Gene

HapMap Linkage Disequilibrium report
CDC42BPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPA Gene

Disorders for CDC42BPA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CDC42BPA Gene in MalaCards »

(1) Diseases for CDC42BPA Gene including...

(1) Novoseek inferred disease relationships for CDC42BPA Gene

Disease -log(P) Hits PubMed IDs
myotonic dystrophy 89.2 20

Relevant External Links for CDC42BPA

Genetic Association Database (GAD)
CDC42BPA
Human Genome Epidemiology (HuGE) Navigator
CDC42BPA
genes like me logo Genes that share disorders with CDC42BPA: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CDC42BPA Gene

Publications for CDC42BPA Gene

  1. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PMID: 11283256) Tan I. … Leung T. (Mol. Cell. Biol. 2001) 3 4 23
  2. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42- binding kinase alpha. (PMID: 11340065) Sumi T. … Nakamura T. (J. Biol. Chem. 2001) 3 4 23
  3. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I. … Leung T. (J. Biol. Chem. 2001) 3 4 23
  4. Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. (PMID: 12568720) Tan I. … Leung T. (Gene 2003) 3 4 23
  5. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. (PMID: 15723050) Wilkinson S. … Marshall C.J. (Nat. Cell Biol. 2005) 3 4 23

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