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Aliases for CDC42BPA Gene

Aliases for CDC42BPA Gene

  • CDC42 Binding Protein Kinase Alpha 2 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Kinase Alpha 3 4
  • CDC42-Binding Protein Kinase Alpha (DMPK-Like) 2 3
  • CDC42 Binding Protein Kinase Alpha (DMPK-Like) 3 5
  • Myotonic Dystrophy Protein Kinase-Like Alpha 3 4
  • DMPK-Like Alpha 3 4
  • EC 2.7.11.1 4 63
  • MRCK Alpha 3 4
  • Ser-Thr Protein Kinase Related To The Myotonic Dystrophy Protein Kinase 3
  • Myotonic Dystrophy Kinase-Related CDC42-Binding Protein Kinase Alpha 3
  • Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase 2
  • CDC42-Binding Protein Kinase Alpha 4
  • CDC42 Binidng Protein Kinase Beta 3
  • Ser-Thr Protein Kinase PK428 3
  • EC 2.7.11 63
  • KIAA0451 4
  • MRCKA 3
  • PK428 3
  • MRCK 3

External Ids for CDC42BPA Gene

Previous GeneCards Identifiers for CDC42BPA Gene

  • GC00U990464
  • GC01M223045
  • GC01M223563
  • GC01M224152
  • GC01M224154
  • GC01M223484
  • GC01M225244
  • GC01M227177
  • GC01M197694

Summaries for CDC42BPA Gene

Entrez Gene Summary for CDC42BPA Gene

  • The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC42BPA Gene

CDC42BPA (CDC42 Binding Protein Kinase Alpha) is a Protein Coding gene. Diseases associated with CDC42BPA include myotonic dystrophy. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot for CDC42BPA Gene

  • Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.

Gene Wiki entry for CDC42BPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42BPA Gene

Genomics for CDC42BPA Gene

Regulatory Elements for CDC42BPA Gene

Promoters for CDC42BPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC42BPA on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC42BPA Gene

Chromosome:
1
Start:
226,989,858 bp from pter
End:
227,318,492 bp from pter
Size:
328,635 bases
Orientation:
Minus strand

Genomic View for CDC42BPA Gene

Genes around CDC42BPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42BPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42BPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42BPA Gene

Proteins for CDC42BPA Gene

  • Protein details for CDC42BPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT25-MRCKA_HUMAN
    Recommended name:
    Serine/threonine-protein kinase MRCK alpha
    Protein Accession:
    Q5VT25
    Secondary Accessions:
    • O75039
    • Q59GZ1
    • Q5H9N9
    • Q5T797
    • Q5VT26
    • Q5VT27
    • Q86XX2
    • Q86XX3
    • Q99646

    Protein attributes for CDC42BPA Gene

    Size:
    1732 amino acids
    Molecular mass:
    197307 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation.
    SequenceCaution:
    • Sequence=BAD92205.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC42BPA Gene

neXtProt entry for CDC42BPA Gene

Proteomics data for CDC42BPA Gene at MOPED

Post-translational modifications for CDC42BPA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for CDC42BPA Gene

Graphical View of Domain Structure for InterPro Entry

Q5VT25

UniProtKB/Swiss-Prot:

MRCKA_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 CNH domain.
  • Contains 1 CRIB domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CDC42BPA: view

Function for CDC42BPA Gene

Molecular function for CDC42BPA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. Inhibited by chelerythrine chloride.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.
UniProtKB/Swiss-Prot Induction:
Regulated by cellular iron levels.

Enzyme Numbers (IUBMB) for CDC42BPA Gene

genes like me logo Genes that share phenotypes with CDC42BPA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42BPA Gene

Localization for CDC42BPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42BPA Gene

Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42BPA Gene COMPARTMENTS Subcellular localization image for CDC42BPA gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with CDC42BPA: view

Pathways & Interactions for CDC42BPA Gene

genes like me logo Genes that share pathways with CDC42BPA: view

Pathways by source for CDC42BPA Gene

1 BioSystems pathway for CDC42BPA Gene
1 GeneGo (Thomson Reuters) pathway for CDC42BPA Gene
1 Qiagen pathway for CDC42BPA Gene

SIGNOR curated interactions for CDC42BPA Gene

Activates:

Gene Ontology (GO) - Biological Process for CDC42BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 9092543
GO:0031032 actomyosin structure organization IMP 18854160
genes like me logo Genes that share ontologies with CDC42BPA: view

Drugs & Compounds for CDC42BPA Gene

(4) Drugs for CDC42BPA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for CDC42BPA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with CDC42BPA: view

Transcripts for CDC42BPA Gene

Unigene Clusters for CDC42BPA Gene

CDC42 binding protein kinase alpha (DMPK-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42BPA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
SP1: - - -
SP2:
SP3: - -
SP4: - -
SP5: - - -
SP6:
SP7:

ExUns: 23b ^ 24 ^ 25a · 25b
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for CDC42BPA Gene

GeneLoc Exon Structure for
CDC42BPA
ECgene alternative splicing isoforms for
CDC42BPA

Expression for CDC42BPA Gene

mRNA expression in normal human tissues for CDC42BPA Gene

Protein differential expression in normal tissues from HIPED for CDC42BPA Gene

This gene is overexpressed in Breast (39.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42BPA Gene



SOURCE GeneReport for Unigene cluster for CDC42BPA Gene Hs.35433

mRNA Expression by UniProt/SwissProt for CDC42BPA Gene

Q5VT25-MRCKA_HUMAN
Tissue specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
genes like me logo Genes that share expression patterns with CDC42BPA: view

Protein tissue co-expression partners for CDC42BPA Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDC42BPA Gene

Orthologs for CDC42BPA Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC42BPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC42BPA 35
  • 92.52 (n)
  • 91.42 (a)
cow
(Bos Taurus)
Mammalia CDC42BPA 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42BPA 36
  • 97 (a)
OneToOne
CDC42BPA 35
  • 90.79 (n)
  • 95.7 (a)
mouse
(Mus musculus)
Mammalia Cdc42bpa 16
Cdc42bpa 36
  • 95 (a)
OneToOne
Cdc42bpa 35
  • 90.73 (n)
  • 96.1 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC42BPA 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42BPA 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc42bpa 35
  • 90.52 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves CDC42BPA 35
  • 82.12 (n)
  • 88.24 (a)
CDC42BPA 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42BPA 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42bpa 35
  • 72.21 (n)
  • 80.48 (a)
zebrafish
(Danio rerio)
Actinopterygii CDC42BPA (1 of 2) 36
  • 72 (a)
OneToMany
CDC42BPA (2 of 2) 36
  • 73 (a)
OneToMany
si:ch211-89p3.3 35
  • 68.65 (n)
  • 74.4 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012090 35
  • 50.51 (n)
  • 50.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta gek 35
  • 49.2 (n)
  • 42.63 (a)
gek 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrck-1 35
  • 52.28 (n)
  • 44.86 (a)
mrck-1 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2297 36
  • 51 (a)
OneToMany
Species with no ortholog for CDC42BPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42BPA Gene

ENSEMBL:
Gene Tree for CDC42BPA (if available)
TreeFam:
Gene Tree for CDC42BPA (if available)

Paralogs for CDC42BPA Gene

Paralogs for CDC42BPA Gene

genes like me logo Genes that share paralogs with CDC42BPA: view

Variants for CDC42BPA Gene

Sequence variations from dbSNP and Humsavar for CDC42BPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_040830 A lung neuroendocrine carcinoma sample
rs34614709 - 227,160,544(+) TTACC(A/G)TTCCA reference, missense
rs56364976 - 227,119,841(+) TTTTG(A/G)TTTGT reference, missense
VAR_040833 -
rs56119119 - 227,091,902(+) CACTC(A/G)TCAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDC42BPA Gene

Variant ID Type Subtype PubMed ID
dgv535n71 CNV Loss 21882294
nsv520923 CNV Loss 19592680
esv2724162 CNV Deletion 23290073
nsv832792 CNV Loss 17160897
dgv536n71 CNV Loss 21882294
nsv468227 CNV Loss 19166990
esv2668013 CNV Deletion 23128226
nsv522990 CNV Loss 19592680
esv33574 CNV Loss 17666407
esv2724173 CNV Deletion 23290073
nsv873242 CNV Loss 21882294
esv2668951 CNV Deletion 23128226
esv22606 CNV Loss 19812545
nsv522490 CNV Loss 19592680
esv2476939 CNV Deletion 19546169
esv2261733 CNV Deletion 18987734
esv2677762 CNV Deletion 23128226
esv273315 CNV Insertion 20981092
esv268982 CNV Insertion 20981092
nsv508063 CNV Loss 20534489
esv1982712 CNV Deletion 18987734
esv2628592 CNV Deletion 19546169
esv4979 CNV Deletion 18987735
esv2724184 CNV Deletion 23290073
esv2565209 CNV Deletion 19546169
esv274526 CNV Insertion 20981092
esv271501 CNV Insertion 20981092

Variation tolerance for CDC42BPA Gene

Residual Variation Intolerance Score: 2.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC42BPA Gene

HapMap Linkage Disequilibrium report
CDC42BPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42BPA Gene

Disorders for CDC42BPA Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC42BPA Gene - From: GeneCards

Disorder Aliases PubMed IDs
myotonic dystrophy
  • curschmann-batten-steinert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDC42BPA

Genetic Association Database (GAD)
CDC42BPA
Human Genome Epidemiology (HuGE) Navigator
CDC42BPA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC42BPA
genes like me logo Genes that share disorders with CDC42BPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC42BPA Gene

Publications for CDC42BPA Gene

  1. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PMID: 11283256) Tan I. … Leung T. (Mol. Cell. Biol. 2001) 3 4 23 67
  2. Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake. (PMID: 20188707) Cmejla R. … Vyoral D. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. (PMID: 18263588) Choi S.H. … Blumberg P.M. (J. Biol. Chem. 2008) 3 23
  4. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. (PMID: 18854160) Tan I. … Leung T. (Cell 2008) 3 23
  5. A novel iron responsive element in the 3'UTR of human MRCKalpha. (PMID: 16412980) Cmejla R. … Cmejlova J. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for CDC42BPA Gene

Sources for CDC42BPA Gene

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