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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC42 Gene

protein-coding   GIFtS: 76
GCID: GC01P022379

cell division cycle 42

(Previous names: cell division cycle 42 (GTP-binding protein, 25kD), cell...)
 Explore 57 diseases affiliated with
CDC42 via
MalaCards
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 Human Malady Compendium 
Biological research products
for CDC42    

Aliases
for CDC42 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle 421 2     DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
CDC42Hs1 2     DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
G25K1 2     Growth-Regulating Protein2
G25K GTP-Binding Protein2 3     GTP Binding Protein, 25kDa2
Cell Division Cycle 42 (GTP Binding Protein, 25kDa)1     GTP-Binding Protein, 25kD2
Cell Division Cycle 42 (GTP-Binding Protein, 25kD)1     Small GTP Binding Protein CDC422
Cell Division Control Protein 42 Homolog2     

External Ids:    HGNC: 17361   Entrez Gene: 9982   Ensembl: ENSG000000708317   OMIM: 1169525   UniProtKB: P609533   

Export aliases for CDC42 gene to outside databases

Previous GC identifers: GC01P021948 GC01P021414 GC01P021525 GC01P021848 GC01P021991 GC01P022235 GC01P020622


Summaries
for CDC42 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDC42:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that
control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This
protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The
product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein
could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP),
which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript
variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound
state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial
cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before
chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin,
actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration

Gene Wiki entry for CDC42


Genomic Views
for CDC42 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC42 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDC42 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1

CDC42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022379:  view genomic region     (about GC identifiers)

Start:
 22,379,120 bp from pter      End:
 22,419,437 bp from pter
Size:
 40,318 bases      Orientation:
 plus strand

Proteins
for CDC42 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953 (See protein sequence)
Recommended Name: Cell division control protein 42 homolog precursor  
Size: 191 amino acids; 21259 Da
Subunit: The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3,
CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with
activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging
GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or
PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by the viral protein
HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42,
CRK, TNK2 and BCAR1/p130cas
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton, centrosome.
Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central
spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular
bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide
exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome
6/29 PDB 3D structures from and Proteopedia for CDC42 (see all 29):
1A4R (3D)        1AJE (3D)        1AM4 (3D)        1AN0 (3D)        1CEE (3D)        1CF4 (3D)    
Secondary accessions: P21181 P25763 Q7L8R5 Q9UDI2
Alternative splicing: 2 isoforms:  P60953-2, P21181-4   P60953-1, P21181-1   

Explore the universe of human proteins at neXtProt for CDC42: NX_P60953

Post-translational modifications:

  • AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and
    • V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase
    activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells.
    It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments
    remain to be done to confirm results in vivo1
  • Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor
    • RhoGDI1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P60953

    • CDC42 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034891.1  NP_001782.1  NP_426359.1  

    ENSEMBL proteins: 
     ENSP00000341072   ENSP00000314458   ENSP00000398327   ENSP00000383118   ENSP00000398592  
    Reactome Protein details: P60953
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CDC42 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): CDC42
    OriGene Protein Over-expression Lysate (see all 3): CDC42
    OriGene Custom Protein Services for CDC42 
    GenScript Custom Purified and Recombinant Proteins Services for CDC42
    Novus Biologicals CDC42 Proteins
    Novus Biologicals CDC42 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CDC42
    Uscn Proteins for CDC42

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11260256
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--


    CDC42 for ontologies           About GeneDecksing



    CDC42 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC42
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDC42  (Cdc42 iso1)
    OriGene Antibodies (see all 2): CDC42
    OriGene Custom Antibody Services for CDC42 
    GenScript Custom Superior Antibodies Services for CDC42
    Novus Biologicals CDC42 Antibodies
    Abcam antibodies for CDC42 
    Uscn Antibodies for CDC42
    ThermoFisher Antibody for CDC42

    Assay Products for CDC42: 
    EMD Millipore Kits and Assays for the Analysis of CDC42
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDC42
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDC42

    Protein Domains /
    Families
    for CDC42 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDC42 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P60953

    ProtoNet protein and cluster: P60953

    3 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
    Similarity: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily


    Function
    for CDC42 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound
    state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial
    cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before
    chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin,
    actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for
    free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase

         Genatlas biochemistry entry for CDC42:
    GTP binding protein 25k,homolog to yeast cdc42,brain,isoform,promoting cell cycle progression from G1 to S,activating
    the Jun N-terminal kinase/stress activated protein kinase required for cell polarization,stimulating the
    actin-depolymerizing activity of WASL,regulating in cooperation with WASP podosomeal adhesion structure in primary
    macrophages

    miRNA
    Products:            		miRTarBase miRNAs that target CDC42:
    hsa-mir-216a (MIRT005964), hsa-mir-137 (MIRT005485), hsa-mir-608 (MIRT005966), hsa-mir-185 (MIRT004037), hsa-mir-330-3p (MIRT005965), hsa-mir-224 (MIRT000636)

    OriGene 3'-UTR Clone (see all 3): CDC42
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC42
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: CDC42 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC42 (see all 7)
    OriGene shRNA RFP: CDC42
    OriGene siRNA: CDC42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC42

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDC42

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC42 (NM_001791)
    Sino Biological Human cDNA Clone for CDC42
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDC42
    Search LifeMap BioReagents cell lines for CDC42

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS11035016
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0030742GTP-dependent protein binding IEA--


    CDC42 for ontologies           About GeneDecksing


    10 GenomeRNAi human phenotypes for CDC42:
     Decreased Hepatitis C virus re  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Increased S DNA content  Increased cell elongation, dec 

    Animal Models:
         Mouse knock-out Cdc42tm1Fwa for CDC42
         15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdc42) (see all 16):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  skeleton 

    CDC42 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDC42 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/120 super-pathways (see all 120) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling_RAC1 in cellular process
    		G-protein signaling_RAC1 in cellular process1.00
    		Cytoskeleton remodeling CDC42 in cellular processes0.37
    		G-protein signaling RAC1 in cellular process1.00
    		CDC42 signaling events0.17
    		Cytoskeleton remodeling_CDC42 in cellular processes0.37
    2GPCR Pathway
    		GPCR Pathway1.00
    		Pancreatic Adenocarcinoma0.55
    		Ras Pathway0.62
    		Paxillin Interactions0.53
    		Breast Cancer Regulation by Stathmin10.58
    3Development_A2B receptor- action via G-protein alpha s
    		Development_A2B receptor- action via G-protein alpha s1.00
    		Development_A2A receptor signaling0.43
    		Development A2B receptor: action via G-protein alpha s1.00
    		Development A2A receptor signaling0.43
    4Activation of p38 alpha/beta MAPK
    		Activation of p38 alpha/beta MAPK1.00
    		CDO in myogenesis0.55
    		Nuclear translocation of p38 MAPK0.94
    		Myogenesis0.55
    5Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80
    		Role of myosins in phagosome formation0.80
    		Branching and elongation of mother and daughter filaments0.29

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/28 EMD Millipore Pathways for CDC42 (see all 28)
        Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration

    1 R&D Systems Pathway for CDC42
        TGF-beta Signaling Pathways

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC42 (see all 56)
        Fc-GammaR Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for CDC42
        MAP Kinase Signaling
    Cytoskeletal Signaling

    5/29 GeneGo (Thomson Reuters) Pathways for CDC42 (see all 29)
        Development A2A receptor signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD16 signaling in NK cells

    5/35 BioSystems Pathways for CDC42 (see all 35) 
        p38 MAPK Signaling Pathway
    G13 Signaling Pathway
    Integrin-mediated cell adhesion
    AGE/RAGE pathway
    TOR signaling

    5/40        Reactome Pathways for CDC42 (see all 40)
        CD28 dependent Vav1 pathway
    Costimulation by the CD28 family
    G alpha (12/13) signalling events
    Signaling by EGFR in Cancer
    Inactivation of Cdc42 and Rac

    1 PharmGKB Pathway for CDC42
        Bisphosphonate Pathway, Pharmacodynamics

    5/21         Kegg Pathways  (Kegg details for CDC42) (see all 21):
        MAPK signaling pathway
    Chemokine signaling pathway
    Endocytosis
    Axon guidance
    VEGF signaling pathway


    CDC42 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/401 Interacting proteins for CDC42 (P609531, 2, 3 ENSP000003144584) via UniProtKB, MINT, STRING, and/or I2D (see all 401)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469401, 2, 3, ENSP000002681824EBI-81752,EBI-297509 MINT-14955 MINT-18637 MINT-18638 MINT-14956 MINT-14954 MINT-16570 MINT-18639 I2D: score=5 STRING: ENSP00000268182
    PAK1Q131531, 2, 3, ENSP000002785684EBI-81752,EBI-1307 MINT-24772 MINT-14490 MINT-7217629 MINT-8078125 MINT-14030 MINT-14489 I2D: score=10 STRING: ENSP00000278568
    WASP427681, 2, 3, ENSP000003658914EBI-81752,EBI-346375 MINT-13944 MINT-13945 MINT-25018 I2D: score=9 STRING: ENSP00000365891
    TRIP10Q156422, 3, ENSP000003204934MINT-15379 MINT-50937 I2D: score=3 STRING: ENSP00000320493
    CDC42EP1Q005871, 3, ENSP000002490144EBI-81752,EBI-744130 I2D: score=6 STRING: ENSP00000249014
    About this table

    Gene Ontology (GO): 5/64 biological process terms (GO ID links to tree view) (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002040sprouting angiogenesis IEA--
    GO:0003161cardiac conduction system development IEA--
    GO:0003334keratinocyte development IEA--
    GO:0006184GTP catabolic process TAS11035016


    CDC42 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDC42 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC42 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CDC42 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ML 141Selective inhibitor of Cdc42 Rho family GTPase[71203-35-5]

    3 HMDB Compounds for CDC42    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CDC42    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminophosphonic Acid-Guanylate Ester-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    10/62 Novoseek chemical compound relationships for CDC42 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 81.9 1 19741094 (1)
    gdp 78.6 74 1429634 (7), 12369824 (4), 18348980 (4), 7918454 (3) (see all 31)
    gtp 76 138 12369824 (5), 8605211 (4), 16784226 (4), 7918454 (4) (see all 55)
    mdi-a 71.6 3 18829452 (1), 18239683 (1), 12445462 (1)
    mant-gdp 64.6 5 8626553 (4)
    phosphatidylinositol 61.3 42 12551955 (4), 15557338 (3), 10793146 (2), 15133042 (2) (see all 24)
    tyrosine 56 49 10587647 (3), 15485841 (2), 10713072 (2), 7542236 (2) (see all 33)
    guanosine 55.3 9 10893268 (2), 8253717 (1), 11371639 (1), 9571239 (1) (see all 8)
    threonine 51.2 25 10947843 (3), 9687501 (1), 11058583 (1), 9683637 (1) (see all 20)
    serine 43.7 22 9687501 (1), 11058583 (1), 9683637 (1), 9760238 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about CDC42 

    Transcripts
    for CDC42 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDC42 gene (3 alternative transcripts): 
    NM_001039802.1  NM_001791.3  NM_044472.2  

    Unigene Cluster for CDC42:

    Cell division cycle 42 (GTP binding protein, 25kDa)
    Hs.467637  [show with all ESTs]
    Unigene Representative Sequence: NM_001039802
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344548(uc009vqg.1 uc001bfq.3) ENST00000315554(uc001bfp.3)
    ENST00000498236 ENST00000411827 ENST00000400259(uc001bfr.3 uc010odr.2 uc010ods.2 uc009vqh.3)
    ENST00000421089

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CDC42
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC42
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: CDC42 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC42 (see all 7)
    OriGene shRNA RFP: CDC42
    OriGene siRNA: CDC42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC42
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC42 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC42 (NM_001791)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDC42
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42

    Additional cDNA sequence: 

    AF498962.1 AF498963.1 AK297465.1 AK303994.1 AK311375.1 AK316449.1 AL121734.1 AL121735.1 
    AL121736.1 AL121737.1 BC002711.2 BC003682.1 BC018266.1 BC018622.1 M35543.1 M57298.1 

    24/33 DOTS entries (see all 33):

    DT.454483  DT.99994472  DT.92457205  DT.121231254  DT.100845422  DT.97860521  DT.100038646  DT.100733144 
    DT.92457158  DT.100657929  DT.95172212  DT.100845424  DT.92457170  DT.121231272  DT.95172226  DT.99949776 
    DT.100038647  DT.121330805  DT.420370  DT.95172215  DT.100733143  DT.100684047  DT.100845415  DT.121330891 

    24/806 AceView cDNA sequences (see all 806):

    BF110210 BM841000 BI061614 BX400172 BM751202 AA932392 AI824342 BF002944 
    BQ302514 AI491943 AA009697 BF195771 AI826658 CA306855 N30479 AL534814 
    W68176 W67717 CR595708 BM754515 AL121736 BE893177 AI084132 AA903625 

    GeneLoc Exon Structure


    Expression
    for CDC42 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTCAATTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDC42 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeLens EctodermLens Ectoderm CellsEctoderm
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    PancreasVentral Pancreatic BudDuct Progenitor CellsPancreas
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDC42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC42

    SOURCE GeneReport for Unigene cluster: Hs.467637
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDC42 (see all 13): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC42
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDC42
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC42
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC42
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42

    Orthologs
    for CDC42 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC42 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDC421 cell division cycle 42 (GTP binding protein, 25kDa) 88.48(n)
    99.48(a)    		   395917  NM_205048.1  NP_990379.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDC426
    		 --
    		 100(a)
    		 1 ↔ 1
    		 AAWZ02040513(4791-6853)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC526192 similar to cell division cycle 42 homolog (S. cerevisiae) 83.77(n)    AF275252.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc639182 hypothetical protein MGC63918 83.19(n)   393605  BC057415.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdc423 axon guidance GTPase 92(a)
    (best of 3)    		   18E1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cdc-423 RAS protein 86(a)
    (best of 4)    		   II(7616169-7617803)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CDC42(YLR229C)4
    CDC421    		 Small rho-like GTPase, essential for establishment more4
    Cdc42p1    		 68.41(n)1
    80.1(a)1    		   12(604787-604212)4
    8509301, 4  NP_013330.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATROP66
    ATRAC16
    (see all 11)    		 Rac-like GTP-binding protein ARAC1
    (see all 11)    		 53(a)
    52(a)
    (see all 11)    		 many ↔ many
    many ↔ many
    (see all 11)    		 4(16672192-16674771)
    2(7739856-7742156)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 ras-related protein, putative, expressed
    (see all 9)    		 52(a)
    51(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 2(1080513-1084283)
    2(35874978-35879805)


    ENSEMBL Gene Tree for CDC42 (if available)
    TreeFam Gene Tree for CDC42 (if available) 

    Paralogs
    for CDC42 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC42 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOG2  RHOU2  RHOBTB22  RAC12  
    RAC22  RHOJ2  RAC32  
    18/57 SIMAP similar genes for CDC42 using alignment to 3 protein entries:     CDC42_HUMAN (see all proteins) (see all similar genes):
    RHOJ    RAC2    RAC3    RHOQ    RAC1    ARHG
    RHOG    RHOU    RHOV    RHOD    RHOC    RHOB
    RHOF    RHOA    RHOH    ARHA    ARHH    ARHE

    CDC42 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for CDC42 (see all 7)
    PGOHUM00000247518 PGOHUM00000246022 PGOHUM00000235456 PGOHUM00000232697 PGOHUM00000232711


    Genomic Variants
    for CDC42 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/790 NCBI SNPs in CDC42 are shown (see all 790)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs749419571,2
    		C,F,--22377142(+) GGGTGC/TGGTGG 3 -- us2k12Minor allele frequency- T:0.13NA EA 240
    rs1915442311,2
    		--22377241(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs75119341,2
    		A--22377269(+) ttagcC/Tgggca 3 -- us2k10--------
    rs75119441,2
    		A--22377305(+) ccactC/Tgggag 3 -- us2k10--------
    rs1113439461,2
    		C,--22377338(+) AACCCA/G/TGGAGG 3 -- us2k10--------
    rs75545781,2
    		C,--22377349(+) CGGAGA/C/GTTGCA 3 -- us2k13NA WA 6
    rs1915157041,2
    		--22377362(+) GAGCCA/GAGATC 3 -- us2k10--------
    rs764149531,2
    		C--22377412(+) CGTCTA/CAAAAA 3 -- us2k10--------
    rs124036471,2
    		C,H--22377491(+) AAATAG/ACTGTG 3 -- us2k14Minor allele frequency- A:0.00NS EA 406
    rs1466807451,2
    		--22377511(+) AATAAA/GTGAGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC42 (22379120 - 22419437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CDC42
         1 CNV: 3286

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing CDC42:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC42
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC42

    Disorders / Diseases
    for CDC42 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDC42 for disorders           About GeneDecksing

    OMIM gene information: 116952    OMIM disorders: --

    20/57 diseases for CDC42 (see all 57):    About MalaCards
    wiskott-aldrich syndrome    aarskog-scott syndrome    familial adenomatous polyposis    adenomatous polyposis coli
    clostridium difficile    anaplastic large cell lymphoma    scott syndrome    oral squamous cell carcinoma
    squamous cell carcinoma    myotonic dystrophy    polyposis    tuberous sclerosis
    neurodegenerative disease    chronic myeloid leukemia    herpes simplex    fanconi's anemia
    werner syndrome    myeloid leukemia    malignant glioma    renal cell carcinoma

    4 diseases from the University of Copenhagen DISEASES database for CDC42:
    Aarskog-Scott syndrome     Wiskott-Aldrich syndrome     Cancer     Myotonic dystrophy

    10/28 Novoseek disease relationships for CDC42 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 83.2 28 15456777 (2), 19741094 (2), 15102814 (2), 10950951 (2) (see all 20)
    temperature-sensitive lethal mutation 60.3 1 2122236 (1)
    metastasis 23.2 10 17970806 (2), 18728402 (2), 20305651 (1), 18044786 (1) (see all 6)
    cancer 9.32 13 17971488 (4), 19416857 (2), 20067638 (2), 16540523 (1) (see all 8)
    tumors 8.58 43 17027002 (5), 12482591 (2), 20067638 (2), 15269155 (2) (see all 23)
    familial adenomatous polyposis 8.35 2 17085436 (1), 15890984 (1)
    dysplasia 8.27 2 9268645 (1), 19261807 (1)
    hypertrophy 4.52 1 11158304 (1)
    pneumonia 3.76 1 15574879 (1)
    adenocarcinoma 2.84 2 18575765 (2)

    Human Genome Epidemiology (HuGE) Navigator: CDC42 (9 documents)
    Tumor Gene Database (TGDB): CDC42

    Export disorders for CDC42 gene to outside databases

    Publications
    for CDC42 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC42 gene, integrated from 9 sources (see all 945):
    (articles sorted by number of sources associating them with CDC42)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. (PubMed id 2122236)1, 2, 3, 9 Munemitsu S....Polakis P. (1990)
    2. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. (PubMed id 2124704)1, 2, 3 Shinjo K.... Cerione R.A. (1990)
    3. Identification of the binding surface on Cdc42Hs for p21-activated kinase. (PubMed id 9760238)1, 2, 9 Guo W.... Oswald R.E. (1998)
    4. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2, 9 Masuda-Robens J.M....Chou M.M. (2003)
    5. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2, 9 Eisenmann K.M.... Iida J. (1999)
    6. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (PubMed id 19039103)1, 2 Yarbrough M.L.... Orth K. (2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)1, 2 Modzelewska K....Keely P.J. (2006)
    9. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. (PubMed id 15642749)1, 2 Oceguera-Yanez F....Narumiya S. (2005)
    10. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PubMed id 14978216)1, 2 Gauthier-Campbell C....El-Husseini A.e.l.-.D. (2004)

    External Searches for CDC42 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDC42 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 998 HGNC: 1736 AceView: CDC42 Ensembl:ENSG00000070831 euGenes: HUgn998
    ECgene: CDC42 Kegg: 998 H-InvDB: CDC42

    Other Databases showing CDC42 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDC42 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC42 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC42 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc42/

    Intellectual Property
    for CDC42 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDC42 gene:
    Search GeneIP for patents involving CDC42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDC42 gene

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    About This Section

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