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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC42 Gene

protein-coding   GIFtS: 74
GCID: GC01P022379

Cell Division Cycle 42

(Previous names: cell division cycle 42 (GTP-binding protein, 25kD), cell...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 421 2     Cell Division Control Protein 42 Homolog2
G25K GTP-Binding Protein2 3     DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
25kDa1     DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
Cell Division Cycle 42 (GTP Binding Protein, 25kDa)1     Growth-Regulating Protein2
Cell Division Cycle 42 (GTP-Binding Protein, 25kD)1     GTP Binding Protein, 25kDa2
GTP Binding Protein1     GTP-Binding Protein, 25kD2
CDC42Hs2     Small GTP Binding Protein CDC422
G25K2     

External Ids:    HGNC: 17361   Entrez Gene: 9982   Ensembl: ENSG000000708317   OMIM: 1169525   UniProtKB: P609533   

Export aliases for CDC42 gene to outside databases

Previous GC identifers: GC01P021948 GC01P021414 GC01P021525 GC01P021848 GC01P021991 GC01P022235 GC01P020622


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC42 Gene:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that
control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression.
This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1
mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this
protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich
syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results
in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and
20. (provided by RefSeq, Apr 2013)

GeneCards Summary for CDC42 Gene: 
CDC42 (cell division cycle 42) is a protein-coding gene. Diseases associated with CDC42 include aarskog-scott syndrome, and wiskott-aldrich syndrome, and among its related super-pathways are Development Slit-Robo signaling and Integrin-mediated cell adhesion. GO annotations related to this gene include protein kinase binding and GTP binding. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved
in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to
kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the
formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration

Gene Wiki entry for CDC42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC42 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDC42 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1

CDC42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022379:  view genomic region     (about GC identifiers)

Start:
22,379,120 bp from pter      End:
22,419,437 bp from pter
Size:
40,318 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953 (See protein sequence)
Recommended Name: Cell division control protein 42 homolog precursor  
Size: 191 amino acids; 21259 Da
Subunit: The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3,
CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with
activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by
exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B
and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by
the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration
composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle
during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase.
Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its
localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating
protein RACGAP1. Colocalizes with NEK6 in the centrosome
6/29 PDB 3D structures from and Proteopedia for CDC42 (see all 29):
1A4R (3D)        1AJE (3D)        1AM4 (3D)        1AN0 (3D)        1CEE (3D)        1CF4 (3D)    
Secondary accessions: P21181 P25763 Q7L8R5 Q9UDI2
Alternative splicing: 2 isoforms:  P60953-2, P21181-4   P60953-1, P21181-1   

Explore the universe of human proteins at neXtProt for CDC42: NX_P60953

Explore proteomics data for CDC42 at MOPED 

Post-translational modifications:

  • UniProtKB: AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and
    V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the
    GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in
    infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but
    additional experiments remain to be done to confirm results in vivo
  • UniProtKB: Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation
    inhibitor RhoGDI
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60953

  • CDC42 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC42 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034891.1  NP_001782.1  NP_426359.1  

    ENSEMBL proteins: 
     ENSP00000341072   ENSP00000314458   ENSP00000398327   ENSP00000383118   ENSP00000398592  
    Reactome Protein details: P60953
    Human Recombinant Protein Products for CDC42: 
    EMD Millipore Purified and/or Recombinant CDC42 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CDC42
    OriGene Protein Over-expression Lysate for CDC42
    OriGene MassSpec for CDC42 
    OriGene Custom Protein Services for CDC42
    GenScript Custom Purified and Recombinant Proteins Services for CDC42
    Novus Biologicals CDC42 Proteins
    Novus Biologicals CDC42 Lysates
    Sino Biological Recombinant Protein for CDC42
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CDC42
    Cloud-Clone Corp. Proteins for CDC42 

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11260256
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    CDC42 for ontologies           About GeneDecksing



    CDC42 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC42
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    LSBio Antibodies in human, mouse, rat for CDC42 

    Assay Products for CDC42: 
    EMD Millipore Kits and Assays for the Analysis of CDC42
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC42 
    Cloud-Clone Corp. CLIAs for CDC42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P60953

    ProtoNet protein and cluster: P60953

    3 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
    Similarity: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily


    CDC42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC42_HUMAN, P60953
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
    GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved
    in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to
    kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the
    formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP
    for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase

         Genatlas biochemistry entry for CDC42:
    GTP binding protein 25k,homolog to yeast cdc42,brain,isoform,promoting cell cycle progression from G1 to
    S,activating the Jun N-terminal kinase/stress activated protein kinase required for cell polarization,stimulating
    the actin-depolymerizing activity of WASL,regulating in cooperation with WASP podosomeal adhesion structure in
    primary macrophages

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS11035016
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0030742GTP-dependent protein binding IEA--
         
    CDC42 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for CDC42:
     Decreased Hepatitis C virus re  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Increased S DNA content  Increased cell elongation, dec 

         15/19 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cdc42) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    CDC42 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdc42tm1Fwa for CDC42

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDC42 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDC42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC42 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC42 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC42:
    hsa-mir-216a (MIRT005964), hsa-mir-137 (MIRT005485), hsa-mir-608 (MIRT005966), hsa-mir-185 (MIRT004037), hsa-mir-330-3p (MIRT005965), hsa-mir-224 (MIRT000636)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC42
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCDC42 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDC42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC42
    Sirion Biotech Customized adenovirus for overexpression of CDC42

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDC42 (see all 19)
    OriGene ORF clones in mouse, rat for CDC42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC42 (NM_001791)
    Sino Biological Human cDNA Clone for CDC42
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42
    Sirion Biotech Customized lentivirus for stable overexpression of CDC42 
                         Customized lentivirus expression plasmids for stable overexpression of CDC42 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDC42
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC42 About   (see all 126)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    3Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Cytoskeleton remodeling FAK signaling0.41
    4Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    VEGF signaling pathway0.39
    5Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    Renal cell carcinoma0.30
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/28 EMD Millipore Pathways for CDC42 (see all 28)
        Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration

    2 R&D Systems Pathways for CDC42
        VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC42 (see all 56)
        Fc-GammaR Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for CDC42
        MAP Kinase Signaling
    Cytoskeletal Signaling

    5/29 GeneGo (Thomson Reuters) Pathways for CDC42 (see all 29)
        Development A2A receptor signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD16 signaling in NK cells

    5/38 BioSystems Pathways for CDC42 (see all 38)
        TOR signaling
    MAPK signaling pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    G13 Signaling Pathway

    2 Sino Biological Pathways for CDC42 
        Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    5/37        Reactome Pathways for CDC42 (see all 37)
        CD28 dependent Vav1 pathway
    Costimulation by the CD28 family
    Developmental Biology
    G alpha (12/13) signalling events
    Signaling by EGFR in Cancer

    1 PharmGKB Pathway for CDC42
        Bisphosphonate Pathway, Pharmacodynamics

    5/25         Kegg Pathways  (Kegg details for CDC42) (see all 25):
        MAPK signaling pathway
    Chemokine signaling pathway
    Endocytosis
    Axon guidance
    VEGF signaling pathway


    CDC42 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/407 Interacting proteins for CDC42 (P609531, 2, 3 ENSP000003144584) via UniProtKB, MINT, STRING, and/or I2D (see all 407)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469401, 2, 3, ENSP000002681824EBI-81752,EBI-297509 MINT-14955 MINT-18637 MINT-18638 MINT-14956 MINT-14954 MINT-16570 MINT-18639 I2D: score=5 STRING: ENSP00000268182
    PAK1Q131531, 2, 3, ENSP000002785684EBI-81752,EBI-1307 MINT-24772 MINT-14490 MINT-7217629 MINT-8078125 MINT-14030 MINT-14489 I2D: score=10 STRING: ENSP00000278568
    WASP427681, 2, 3, ENSP000003658914EBI-81752,EBI-346375 MINT-13944 MINT-13945 MINT-25018 I2D: score=9 STRING: ENSP00000365891
    TRIP10Q156422, 3, ENSP000003204934MINT-15379 MINT-50937 I2D: score=3 STRING: ENSP00000320493
    CDC42EP1Q005871, 3, ENSP000002490144EBI-81752,EBI-744130 I2D: score=6 STRING: ENSP00000249014
    About this table

    Gene Ontology (GO): 5/68 biological process terms (GO ID links to tree view) (see all 68):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002040sprouting angiogenesis IEA--
    GO:0003161cardiac conduction system development IEA--
    GO:0003334keratinocyte development IEA--
    GO:0006184GTP catabolic process TAS11035016

    CDC42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC42 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC42

    3 HMDB Compounds for CDC42    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CDC42    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminophosphonic Acid-Guanylate Ester-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    10/62 Novoseek inferred chemical compound relationships for CDC42 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 81.9 1 19741094 (1)
    gdp 78.6 74 1429634 (7), 12369824 (4), 18348980 (4), 7918454 (3) (see all 31)
    gtp 76 138 12369824 (5), 8605211 (4), 16784226 (4), 7918454 (4) (see all 55)
    mdi-a 71.6 3 18829452 (1), 18239683 (1), 12445462 (1)
    mant-gdp 64.6 5 8626553 (4)
    phosphatidylinositol 61.3 42 12551955 (4), 15557338 (3), 10793146 (2), 15133042 (2) (see all 24)
    tyrosine 56 49 10587647 (3), 15485841 (2), 10713072 (2), 7542236 (2) (see all 33)
    guanosine 55.3 9 10893268 (2), 8253717 (1), 11371639 (1), 9571239 (1) (see all 8)
    threonine 51.2 25 10947843 (3), 9687501 (1), 11058583 (1), 9683637 (1) (see all 20)
    serine 43.7 22 9687501 (1), 11058583 (1), 9683637 (1), 9760238 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about CDC42

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC42 gene (3 alternative transcripts): 
    NM_001039802.1  NM_001791.3  NM_044472.2  

    Unigene Cluster for CDC42:

    Cell division cycle 42
    Hs.467637  [show with all ESTs]
    Unigene Representative Sequence: NM_001039802
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344548(uc009vqg.1 uc001bfq.3) ENST00000315554(uc001bfp.3)
    ENST00000498236 ENST00000411827 ENST00000400259(uc001bfr.3 uc010odr.2 uc010ods.2 uc009vqh.3)
    ENST00000421089
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC42
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCDC42 3' UTR sequence
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    Additional mRNA sequence: 

    AF498962.1 AF498963.1 AK297465.1 AK303994.1 AK311375.1 AK316449.1 AL121734.1 AL121735.1 
    AL121736.1 AL121737.1 BC002711.2 BC003682.1 BC018266.1 BC018622.1 M35543.1 M57298.1 

    24/35 DOTS entries (see all 35):

    DT.454483  DT.99994472  DT.92457205  DT.100845422  DT.100657929  DT.92457158  DT.121231254  DT.97860521 
    DT.100038646  DT.100733144  DT.99949776  DT.95172212  DT.100845424  DT.92457170  DT.121231272  DT.100038647 
    DT.95172226  DT.121330805  DT.420370  DT.95172215  DT.100733143  DT.95172227  DT.100684047  DT.100845415 

    24/806 AceView cDNA sequences (see all 806):

    BU730155 AA319005 AA234137 AL121736 BF195771 CR595708 BU507536 BF110210 
    BM452909 AL704762 BM148068 BM835345 AA057277 BE893177 AV728663 AU280735 
    AI473768 AU146548 AI309937 AI140145 CA314939 BM555240 AW949374 CA308985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC42 expression in normal human tissues (normalized intensities)      CDC42 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAATTCT
    CDC42 Expression
    About this image


    CDC42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Brain (Nervous System)
             brain/hindbrain   
     
     Pancreas (Endocrine System)
             Duct Progenitor Cells Ventral Pancreatic Bud

    See CDC42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC42

    SOURCE GeneReport for Unigene cluster: Hs.467637
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDC42 (see all 13): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC42 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc421 , 5 cell division cycle 42 homolog (S. cerevisiae)5
    cell division cycle 421
    95.81(n)1
    100(a)1
      4 (69.83 cM)5
    125401  NM_009861.31  NP_033991.11 
     1373196965 
    chicken
    (Gallus gallus)
    Aves CDC421 cell division cycle 42 (GTP binding protein, 25kDa) 88.48(n)
    99.48(a)
      395917  NM_205048.1  NP_990379.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC426
    Uncharacterized protein
    100(a)
    1 ↔ 1
    AAWZ02040513(4686-6853)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC526192 similar to cell division cycle 42 homolog (S. cerevisiae) 83.77(n)    AF275252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639182 hypothetical protein MGC63918 83.19(n)   393605  BC057415.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdc423 axon guidance GTPase 92(a)
    (best of 3)
      18E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-423 RAS protein 86(a)
    (best of 4)
      II(7616169-7617803)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC42(YLR229C)4
    CDC421
    Small rho-like GTPase, essential for establishment more4
    Cdc42p1
    68.41(n)1
    80.1(a)1
      12(604787-604212)4
    8509301, 4  NP_013330.11, 4 


    ENSEMBL Gene Tree for CDC42 (if available)
    TreeFam Gene Tree for CDC42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC42 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  
    RAC22  RHOJ2  RAC32  
    18/53 SIMAP similar genes for CDC42 using alignment to 3 protein entries:     CDC42_HUMAN (see all proteins) (see all similar genes):
    RHOJ    RAC2    RAC3    RHOQ    RAC1    ARHG
    RHOG    RHOU    RHOV    RHOD    RHOC    RHOB
    RHOF    RHOA    RHOH    ARHA    ARHH    ARHE

    CDC42 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for CDC42 (see all 7)
    PGOHUM00000247518 PGOHUM00000246022 PGOHUM00000235456 PGOHUM00000232697 PGOHUM00000232711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/958 SNPs in CDC42 are shown (see all 958)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178379991,2
    C,F--20627876(+) TCTATGT/-TGGTC 3 -- int12Minor allele frequency- -:0.12NS NA 172
    rs749419571,2
    C,F--22377142(+) GGGTGC/TGGTGG 3 -- us2k12Minor allele frequency- T:0.13NA EA 240
    rs1915442311,2
    --22377241(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs75119341,2
    A--22377269(+) ttagcC/Tgggca 3 -- us2k10--------
    rs75119441,2
    A--22377305(+) ccactC/Tgggag 3 -- us2k10--------
    rs1113439461,2
    C--22377338(+) AACCCA/G/TGGAGG 3 -- us2k10--------
    rs75545781,2
    C--22377349(+) cggagA/C/Gttgca 3 -- us2k13NA WA 6
    rs1915157041,2
    --22377362(+) GAGCCA/GAGATC 3 -- us2k10--------
    rs764149531,2
    C--22377412(+) CGTCTA/CAAAAA 3 -- us2k10--------
    rs124036471,2
    C,H--22377491(+) AAATAG/ACTGTG 3 -- us2k14Minor allele frequency- A:0.00NS EA 406

    HapMap Linkage Disequilibrium report for CDC42 (22379120 - 22419437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDC42:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6076CNV Insertion18451855
    nsv834413CNV Loss17160897
    nsv528664CNV Gain19592680
    nsv871778CNV Gain21882294
    dgv43e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    Glioma
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    SeqTarget long-range PCR primers for resequencing CDC42
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116952    OMIM disorders: --

    20/55 diseases for CDC42 (see all 55):    About MalaCards
    aarskog-scott syndrome    wiskott-aldrich syndrome    scott syndrome    clostridium difficile
    tuberous sclerosis complex    blastoma    werner syndrome    familial adenomatous polyposis
    noma    shigellosis    smallpox    testicular cancer
    anaplastic large cell lymphoma    myotonic dystrophy    lissencephaly    tuberous sclerosis
    retinoblastoma    pertussis    fanconi's anemia    chronic myeloid leukemia

    4 diseases from the University of Copenhagen DISEASES database for CDC42:
    Aarskog-Scott syndrome     Wiskott-Aldrich syndrome     Cancer     Myotonic dystrophy

    CDC42 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/28 Novoseek inferred disease relationships for CDC42 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 83.2 28 15456777 (2), 19741094 (2), 15102814 (2), 10950951 (2) (see all 20)
    temperature-sensitive lethal mutation 60.3 1 2122236 (1)
    metastasis 23.2 10 17970806 (2), 18728402 (2), 20305651 (1), 18044786 (1) (see all 6)
    cancer 9.32 13 17971488 (4), 19416857 (2), 20067638 (2), 16540523 (1) (see all 8)
    tumors 8.58 43 17027002 (5), 12482591 (2), 20067638 (2), 15269155 (2) (see all 23)
    familial adenomatous polyposis 8.35 2 17085436 (1), 15890984 (1)
    dysplasia 8.27 2 9268645 (1), 19261807 (1)
    hypertrophy 4.52 1 11158304 (1)
    pneumonia 3.76 1 15574879 (1)
    adenocarcinoma 2.84 2 18575765 (2)

    Genetic Association Database (GAD): CDC42
    Human Genome Epidemiology (HuGE) Navigator: CDC42 (9 documents)
    Tumor Gene Database (TGDB): CDC42

    Export disorders for CDC42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC42 gene, integrated from 9 sources (see all 966):
    (articles sorted by number of sources associating them with CDC42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. (PubMed id 2122236)1, 2, 3, 9 Munemitsu S....Polakis P. (1990)
    2. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. (PubMed id 2124704)1, 2, 3 Shinjo K.... Cerione R.A. (1990)
    3. Identification of the binding surface on Cdc42Hs for p21-activated kinase. (PubMed id 9760238)1, 2, 9 Guo W.... Oswald R.E. (1998)
    4. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2, 9 Masuda-Robens J.M....Chou M.M. (2003)
    5. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2, 9 Eisenmann K.M.... Iida J. (1999)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (2010)
    8. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (PubMed id 19039103)1, 2 Yarbrough M.L.... Orth K. (2009)
    9. Genome-wide scan of 500,000 single-nucleotide polymor phisms among responders and nonresponders to interferon beta therapy in multipl e sclerosis. (PubMed id 19667218)1, 4 Comabella M....Montalban X. (2009)
    10. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 998 HGNC: 1736 AceView: CDC42 Ensembl:ENSG00000070831 euGenes: HUgn998
    ECgene: CDC42 Kegg: 998 H-InvDB: CDC42

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC42 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC42 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc42/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC42 gene:
    Search GeneIP for patents involving CDC42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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