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CDC42 Gene

protein-coding GIFtS: 68

GC01P022235

cell division cycle 42 (GTP binding protein, 25kDa)
(Previous names: cell division cycle 42 (GTP-binding protein, 25kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDC42Hs ^¹, ²
G25K ^¹, ²
OTTHUMP00000002834 ^²
OTTHUMP00000002926 ^²

Descriptions
G25K GTP-binding protein ^³
GTP-binding protein, 25kD ^²
cell division cycle 42 ^²
cell division cycle 42 (GTP binding protein, 25kD) ^²
cell division cycle 42 (GTP binding protein, 25kDa) ^²
cell division cycle 42 (GTP-binding protein, 25kD) ^¹, ²
dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) ^²
dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) ^²
growth-regulating protein ^²
small GTP binding protein CDC42 ^²

External Ids
HGNC: 1736¹
Entrez Gene: 998²
UniProtKB: P60953³
Ensembl: ENSG00000070831⁷

Search outside databases for aliases for CDC42 gene

Previous GC identifers: GC01P021948 GC01P021414 GC01P021525 GC01P021848 GC01P021991

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDC42:

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling

pathways that control diverse cellular functions including cell morphology, migration, endocytosis

and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and

is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to

specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin

polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP),

which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple

transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953

Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an

inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate

cellular responses. Involved in epithelial cell polarization processes. Causes the formation of

thin, actin-rich surface projections called filopodia

Gene Wiki entry for CDC42

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDC42 gene

Entrez Gene cytogenetic band: 1p36.1 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.1

CDC42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P022235: (about GC identifiers)

Start:	22,235,157 bp from pter
End:	22,292,024 bp from pter
Size:	56,868 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953 (See protein sequence)

Recommended Name: Cell division control protein 42 homolog precursor

Size: 191 amino acids; 21311 Da

Subunit: The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1,

CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a

GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with

Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with

NET1 and TCGAP/SNX26. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

PDB structures from and Proteopedia :

1A4R (3D)

1AJE (3D)

1AM4 (3D)

1AN0 (3D)

1CEE (3D)

1CF4 (3D)

1DOA (3D)

1E0A (3D)

1EES (3D)

1GRN (3D)

1GZS (3D)

1KI1 (3D)

1KZ7 (3D)

1KZG (3D)

1NF3 (3D)

2ASE (3D)

2DFK (3D)

2NGR (3D)

2ODB (3D)

2QRZ (3D)

Secondary accessions: P21181 P25763 Q7L8R5

Alternative splicing: 2 isoforms: P60953-1, P21181-1 P60953-2, P21181-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001034891.1 NP_001782.1 NP_426359.1

ENSEMBL proteins:

ENSP00000337669 ENSP00000314458 ENSP00000341072 ENSP00000383118

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CDC42 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAC1 + Cdc42, CDC42, Pan Rho + RAC (1,2,3) + CDC42)
	Human Recombinant Proteins from Abnova (CDC42)

OriGene Purified Recombinant Human Proteins (see all 3): CDC42

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IDA	11260256
GO:0005829	cytosol	EXP	14505571 16407834
GO:0005886	plasma membrane	IDA	11260256
GO:0030175	filopodium	IDA	11035016

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Antibodies for CDC42:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CDC42
	Sigma-Aldrich Antibodies for CDC42
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDC42
	Antibodies from Abcam (RAC1 + Cdc42, CDC42, Pan Rho + RAC (1,2,3) + CDC42), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDC42)
	Novus Biologicals Antibody for CDC42

Assays for CDC42:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CDC42
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P60953

ProtoNet protein and cluster: P60953

3 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953

Similarity: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC42)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDC42)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001791

Applied Biosystems Silencer® siRNAs for CDC42

Sigma-Aldrich siRNA and siRNA Panels for CDC42

Sigma-Aldrich shRNA Panels and shRNA for CDC42

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDC42
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039802
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039802
untagged cDNA clones in CMV expression vector (see all 3): NM_001039802

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001791

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953

Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an

inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate

cellular responses. Involved in epithelial cell polarization processes. Causes the formation of

thin, actin-rich surface projections called filopodia

Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the

exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP

hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the

nucleotide from the GTPase

Genatlas biochemistry entry for CDC42:

GTP binding protein 25k,homolog to yeast cdc42,brain,isoform,promoting cell cycle progression from

G1 to S,activating the Jun N-terminal kinase/stress activated protein kinase required for cell

polarization,stimulating the actin-depolymerizing activity of WASL,regulating in cooperation with

WASP podosomeal adhesion structure in primary macrophages

5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdc42):

growth/size

lethality-prenatal/perinatal

nervous system

skin/coat/nails

vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	11035016
GO:0005515	protein binding	IPI	10587647 10816584 11035016
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/25 Sigma-Aldrich "Your Favorite Gene" Pathways for CDC42 (Your Favorite Gene powered by Ingenuity) (see all 25 )

Germ Cell-Sertoli Cell Junction Signaling
Tight Junction Signaling
LPS-stimulated MAPK Signaling
Actin Cytoskeleton Signaling
Renal Cell Carcinoma Signaling

GeneDecks CDC42 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDC42

5/359 Interacting proteins for CDC42 (P60953^{1, 2} ENSP00000314458³) via UniProtKB, MINT, and/or STRING (see all 359 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986², ENSP00000274335³	MINT-15429 MINT-19007 MINT-19008 MINT-15428 MINT-19009 STRING (score=.998)
TRIP10	Q15642², ENSP00000320117³	MINT-15379 MINT-50937 STRING (score=.999)
ARHGAP1	Q07960¹, ENSP00000310491³	EBI-287394, EBI-602762 STRING (score=.999)
ARHGDIA	P52565¹, ENSP00000269321³	EBI-81752, EBI-712693 STRING (score=.999)
ARHGEF7	Q14155², ENSP00000364893³	MINT-3372015 STRING (score=.999)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007163	establishment or maintenance of cell polarity	TAS	11260256
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0030036	actin cytoskeleton organization	IDA	11035016
GO:0030225	macrophage differentiation	TAS	11260256
GO:0031274	positive regulation of pseudopodium formation	IDA	11035016

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CDC42
10/36 Novoseek chemical compound relationships for CDC42 gene (see all 36 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	78.73	71	1429634 (7), 12369824 (4), 18348980 (4), 7918454 (3) (see all 30)
gtp	76.78	135	12369824 (5), 8605211 (4), 16784226 (4), 7918454 (4) (see all 54)
mdi-a	72.86	3	18829452 (1), 18239683 (1), 12445462 (1)
mant-gdp	66.10	5	8626553 (4)
phosphatidylinositol	60.63	41	12551955 (4), 15557338 (3), 10793146 (2), 15133042 (2) (see all 23)
guanosine	55.59	9	10893268 (2), 8253717 (1), 11371639 (1), 9571239 (1) (see all 8)
tyrosine	54.74	44	10587647 (3), 15485841 (2), 10713072 (2), 8497321 (2) (see all 29)
threonine	51.50	23	10947843 (3), 9687501 (1), 11058583 (1), 9683637 (1) (see all 18)
phosphatidylinositol-3,4,5-trisphosphate	43.12	2	15728722 (1), 9804788 (1)
phosphoinositide	42.75	8	17682062 (2), 11038173 (1), 9381982 (1), 11865026 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC42)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDC42)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001791

Sigma-Aldrich siRNA and siRNA Panels for CDC42

Sigma-Aldrich shRNA Panels and shRNA for CDC42

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039802 NM_001791 NM_044472

REFSEQ mRNAs for CDC42 gene (3 alternative transcripts):

NM_001039802.1 NM_001791.3 NM_044472.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039802 NM_001791 NM_044472

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039802
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039802
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001039802

Additional cDNA sequence:

AF498962.1 AF498963.1 AK297465.1 AK303994.1 AK311375.1 AK316449.1 AL121734.1 AL121735.1

AL121736.1 AL121737.1 BC002711.2 BC003682.1 BC018266.1 BC018622.1 CR590120.1 CR595708.1

CR596776.1 CR601442.1 CR623987.1 M35543.1 M57298.1

24/33 DOTS entries (see all 33 ):

DT.454483 DT.99994472 DT.92457205 DT.121231254 DT.100845422 DT.97860521 DT.100038646 DT.100733144

DT.92457158 DT.100657929 DT.95172212 DT.100845424 DT.92457170 DT.121231272 DT.95172226 DT.99949776

DT.100038647 DT.121330805 DT.420370 DT.95172215 DT.100733143 DT.100684047 DT.100845415 DT.121330891

24/806 AceView cDNA sequences (see all 806 ):

BU507536 F12009 AA009697 AL513708 AA843430 CA489192 BM825780 BI093229

AU146548 BU187423 BE219519 AA319723 BQ417134 F08957 BQ938153 AI824342

AI076212 AA701997 BM146780 BF002944 AA903625 BM452909 W68176 CA311415

highest scoring ESTs for CDC42:

AA022562 AA022580 AA029218 AA029219 AA035181 AA035182 AA043554 AA057277 AA058722 AA176302

Unigene Cluster for CDC42:

Cell division cycle 42 (GTP binding protein, 25kDa)

Hs.690198 [show with all ESTs]

Unigene Representative Sequence: NM_001039802

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000337517 ENST00000315554 ENST00000344548 ENST00000400259

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDC42 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDC42

¹ / ² / ³

14 probe-sets matching CDC42 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
959_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.55	HG2463-HT2559	0.20	1.00	0.72	1
39736_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.98	M35543	0.80	1.00	0.91	1
960_g_at²^{, 3}	U95-A	3	1.00	0.65	0.29	1.57	HG2463-HT2559	0.20	1.00	0.72	1
40192_at*²^{, 3}	U95-A	1	1.00	1.00	-0.28	0.22	L10844	0.60	1.00	0.82	1
210232_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M35543	0.80	1.00	0.91	1
214230_at²^{, 3}	U133-A	1	1.00	1.00	--	--	R37664	0.40	1.00	0.76	1
208728_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003682	0.80	1.00	0.91	1
208727_s_at²^{, 3}	U133-A	3	1.00	0.80	--	--	BC002711	0.80	1.00	0.91	1
207273_at*²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210232_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214230_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208728_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208727_s_at²	U133Plus2	3	1.00	0.80	--	--	--	--	--	--	--
207273_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDC42 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTCAATTCT

SOURCE GeneReport for Unigene cluster: Hs.690198
Expression variation in blood from EXPOLDB for CDC42

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC42 gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDC42¹	--	cell division cycle 42 (GTP binding protein, 25kDa)	97.21(n) 99.48(a)	607535 XM_844239.1 XP_849332.1
chimpanzee (Pan troglodytes)	CDC42¹	--	cell division cycle 42 (GTP binding protein, 25kDa)	99.83(n) 100(a)	456609 XM_513185.2 XP_513185.2
cow (Bos taurus)	CDC42¹	--	cell division cycle 42 (GTP binding protein, 25kDa)	96.16(n) 100(a)	532712 NM_001046332.1 NP_001039797.1
mouse (Mus musculus)	Cdc42⁵	4 (66.75 cM)	cell division cycle 42 homolog (S. cerevisiae)	--	U76960
chicken (Gallus gallus)	CDC42¹	--	cell division cycle 42 (GTP binding protein, 25kDa)	88.48(n) 99.48(a)	395917 NM_205048.1 NP_990379.1

About this table Species with no ortholog for CDC42

ENSEMBL Gene Tree for CDC42

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDC42 gene

RHOQ² RHOJ²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/432 NCBI SNPs in CDC42 are shown (see all 432 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 75)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7519109^1,2	A,C,F,H	22290130(+)	`ATCCAA/GCTGTT`	3	--	int¹ ng3¹		5	NS EU EA WA	584
--	rs6690757^1,2	A,C,F,H	22273223(+)	`tcttgG/Tctcac`	3	--	ut5¹ int¹ ese³		5	EU EA WA NS	548
	rs722697^1,2	A,C,F,H	22292346(-)	`GCTTTC/TCAATG`	2	--	ng3¹		9	NA EU EA WA NS	924
	rs2473325^1,2	A,C,F	22251675(-)	`TGGGGT/CGGGTC`	3	--	ng5¹		1	NS	174
	rs16826470^1,2	C,F,H	22277513(+)	`GGTCAT/ACATCA`	3	--	ut5¹		8	NA NS EU EA WA	726
--	rs3754496^1,2	A,C,F	22251467(-)	`GCCCAG/TACTGG`	3	--	ng5¹		1	NS	140
--	rs3754497^1,2	A,C,F	22251257(-)	`tgcctC/Tgacct`	3	--	ng5¹		1	NS	174
--	rs17837990^1,2	C,F	22290095(+)	`TGACCC/TGTGCC`	3	--	int¹ ng3¹		7	NS	832
--	rs11580192^1,2	C,F	22251142(+)	`CTTCCG/ATCTTC`	3	--	ng5¹		1	NS	172
--	rs725157^1,2	C,F	22251075(+)	`AGGCCC/GGGGGA`	3	--	ng5¹		1	NS	168

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HapMap Linkage Disequilibrium images for CDC42 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 116952

10/26 Novoseek disease relationships for CDC42 gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	82.55	25	15456777 (2), 10950951 (2), 15102814 (2), 9422512 (1) (see all 18)
temperature-sensitive lethal mutation	60.61	1	2122236 (1)
metastasis	18.11	9	17970806 (2), 18728402 (2), 11768613 (1), 18044786 (1) (see all 5)
familial adenomatous polyposis	10.29	2	17085436 (1), 15890984 (1)
dysplasia	7.14	2	9268645 (1), 19261807 (1)
hypertrophy	4.88	1	11158304 (1)
pneumonia	4.22	1	15574879 (1)
adenocarcinoma	3.08	2	18575765 (2)
tumors	2.97	37	17027002 (5), 12482591 (2), 15269155 (2), 16395716 (2) (see all 20)
hiv infections	2.10	2	15574879 (2)

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Human Genome Epidemiology Navigator: CDC42 (2 documents)
Tumor Gene Database: CDC42

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/793 PubMed articles for CDC42 gene (see all 793 ):

Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. (PubMed id 2122236)^{1, 2, 3, 4} Munemitsu S....Polakis P. (1990)
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. (PubMed id 2124704)^{2, 3, 4} Shinjo K.... Cerione R.A. (1990)
Identification of the binding surface on Cdc42Hs for p21-activated kinase. (PubMed id 9760238)^{1, 3, 4} Guo W.... Oswald R.E. (1998)
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)^{1, 3, 4} Eisenmann K.M.... Iida J. (1999)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. (PubMed id 12172552)^{3, 4} Meller N....Schwartz M.A. (2002)
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. (PubMed id 11260256)^{3, 4} Noda Y....Sumimoto H. (2001)
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. (PubMed id 11130076)^{3, 4} Miki H.... Takenawa T. (2000)
SPECs, small binding proteins for Cdc42. (PubMed id 10816584)^{3, 4} Pirone D.M.... Burbelo P.D. (2000)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 998	HGNC: 1736	AceView: CDC42	Ensembl:ENSG00000070831	euGenes: HUgn998
ECgene: CDC42	H-InvDB: CDC42

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDC42	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc42/

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Products for CDC42:

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CDC42 Gene

protein-coding GIFtS: 68

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDC42 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CDC42

Summariesfor CDC42

Genomic Locationfor CDC42

Proteinsfor CDC42

Protein Domains/Familiesfor CDC42

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDC42

Summaries
for CDC42

Genomic Location
for CDC42

Proteins
for CDC42

Protein Domains/
Families
for CDC42

Gene Function
for CDC42

Pathways & Interactions
for CDC42

Drugs & Compounds
for CDC42

Transcripts
for CDC42

Expression
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Orthologs
for CDC42

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for CDC42

SNPs/Variants
for CDC42

Disorders & Mutations
for CDC42

Medical News
for CDC42

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for CDC42

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