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Aliases for CDC42 Gene

Aliases for CDC42 Gene

  • Cell Division Cycle 42 2 3 5
  • G25K GTP-Binding Protein 3 4
  • DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)) 3
  • DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD)) 3
  • Cell Division Cycle 42 (GTP Binding Protein, 25kDa) 2
  • Cell Division Cycle 42 (GTP-Binding Protein, 25kD) 2
  • Small GTP Binding Protein CDC42 3
  • GTP Binding Protein, 25kDa 3
  • GTP-Binding Protein, 25kD 3
  • Growth-Regulating Protein 3
  • GTP Binding Protein 2
  • CDC42Hs 3
  • 25kDa 2
  • G25K 3
  • TKS 3

External Ids for CDC42 Gene

Previous GeneCards Identifiers for CDC42 Gene

  • GC01P021948
  • GC01P021414
  • GC01P021525
  • GC01P021848
  • GC01P021991
  • GC01P022235
  • GC01P022379
  • GC01P020622

Summaries for CDC42 Gene

Entrez Gene Summary for CDC42 Gene

  • The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

GeneCards Summary for CDC42 Gene

CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Wiskott-Aldrich Syndrome and Shigellosis. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial invasion of epithelial cells. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for CDC42 Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Gene Wiki entry for CDC42 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC42 Gene

Genomics for CDC42 Gene

Regulatory Elements for CDC42 Gene

Enhancers for CDC42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC42 on UCSC Golden Path with GeneCards custom track

Promoters for CDC42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC42 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC42 Gene

Chromosome:
1
Start:
22,052,627 bp from pter
End:
22,092,946 bp from pter
Size:
40,320 bases
Orientation:
Plus strand

Genomic View for CDC42 Gene

Genes around CDC42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC42 Gene

Proteins for CDC42 Gene

  • Protein details for CDC42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60953-CDC42_HUMAN
    Recommended name:
    Cell division control protein 42 homolog
    Protein Accession:
    P60953
    Secondary Accessions:
    • P21181
    • P25763
    • Q7L8R5
    • Q9UDI2

    Protein attributes for CDC42 Gene

    Size:
    191 amino acids
    Molecular mass:
    21259 Da
    Quaternary structure:
    • The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42.

    Three dimensional structures from OCA and Proteopedia for CDC42 Gene

    Alternative splice isoforms for CDC42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC42 Gene

Proteomics data for CDC42 Gene at MOPED

Post-translational modifications for CDC42 Gene

  • (Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of CDC42 and leads to actin disassembly.
  • Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.
  • Ubiquitination at Lys 107, Lys 133, Lys 144, Lys 153, Lys 183, and Lys 184
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC42 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC42 (CDC42)

No data available for DME Specific Peptides for CDC42 Gene

Domains & Families for CDC42 Gene

Gene Families for CDC42 Gene

Suggested Antigen Peptide Sequences for CDC42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60953

UniProtKB/Swiss-Prot:

CDC42_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
Family:
  • Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
genes like me logo Genes that share domains with CDC42: view

Function for CDC42 Gene

Molecular function for CDC42 Gene

GENATLAS Biochemistry:
GTP binding protein 25k,homolog to yeast cdc42,brain,isoform,promoting cell cycle progression from G1 to S,activating the Jun N-terminal kinase/stress activated protein kinase required for cell polarization,stimulating the actin-depolymerizing activity of WASL,regulating in cooperation with WASP podosomeal adhesion structure in primary macrophages
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Gene Ontology (GO) - Molecular Function for CDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA,IPI 21048939
GO:0051022 Rho GDP-dissociation inhibitor binding IEA --
genes like me logo Genes that share ontologies with CDC42: view
genes like me logo Genes that share phenotypes with CDC42: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC42 Gene

Localization for CDC42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC42 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC42 Gene COMPARTMENTS Subcellular localization image for CDC42 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
vacuole 5
golgi apparatus 4
nucleus 3
endosome 2
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA,IDA 11807099
GO:0031256 leading edge membrane IEA --
GO:0043005 neuron projection IDA 21048939
genes like me logo Genes that share ontologies with CDC42: view

Pathways & Interactions for CDC42 Gene

genes like me logo Genes that share pathways with CDC42: view

Pathways by source for CDC42 Gene

SIGNOR curated interactions for CDC42 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0003334 keratinocyte development IEA --
GO:0006897 endocytosis IEA --
GO:0007030 Golgi organization IEA,ISS --
GO:0007088 regulation of mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CDC42: view

Drugs & Compounds for CDC42 Gene

(36) Drugs for CDC42 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Aminophosphonic Acid-Guanylate Ester Experimental Pharma Target 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
ZCL278 Pharma Selective Cdc42 inhibitor 0

(31) Additional Compounds for CDC42 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDC42 Gene

Compound Action Cas Number
ZCL278 Selective Cdc42 inhibitor 587841-73-4
genes like me logo Genes that share compounds with CDC42: view

Transcripts for CDC42 Gene

Unigene Clusters for CDC42 Gene

Cell division cycle 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC42 Gene

No ASD Table

Relevant External Links for CDC42 Gene

GeneLoc Exon Structure for
CDC42
ECgene alternative splicing isoforms for
CDC42

Expression for CDC42 Gene

mRNA expression in normal human tissues for CDC42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC42 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for CDC42 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC42 Gene



SOURCE GeneReport for Unigene cluster for CDC42 Gene Hs.467637

genes like me logo Genes that share expression patterns with CDC42: view

Protein tissue co-expression partners for CDC42 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDC42 Gene

Orthologs for CDC42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC42 35
  • 96.16 (n)
  • 100 (a)
CDC42 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC42 35
  • 97.38 (n)
  • 100 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
CDC42 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CDC42 35
  • 99.83 (n)
  • 100 (a)
CDC42 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdc42 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC42 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC42 35
  • 88.48 (n)
  • 99.48 (a)
CDC42 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC42 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc42 35
  • 84.12 (n)
  • 98.43 (a)
Str.6147 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52619 35
zebrafish
(Danio rerio)
Actinopterygii cdc42l 35
  • 73.47 (n)
  • 91.1 (a)
zgc63918 35
cdc42 36
  • 99 (a)
OneToMany
CDC42 (4 of 4) 36
  • 20 (a)
OneToMany
cdc42l 36
  • 91 (a)
OneToMany
cdc42l2 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4093 35
fruit fly
(Drosophila melanogaster)
Insecta Cdc42 37
  • 92 (a)
Mtl 37
  • 63 (a)
RhoL 37
  • 47 (a)
Cdc42 35
  • 72.43 (n)
  • 92.67 (a)
Cdc42 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CDC42_ANOGA 35
  • 73.3 (n)
  • 92.67 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-42 37
  • 86 (a)
F22E12.2 37
  • 45 (a)
mig-2 37
  • 59 (a)
Y32F6B.3 37
  • 44 (a)
cdc-42 35
  • 71.9 (n)
  • 86.39 (a)
cdc-42 36
  • 86 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL093W 35
  • 65.79 (n)
  • 80.1 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04213g 35
  • 69.46 (n)
  • 80.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 35
  • 68.41 (n)
  • 80.1 (a)
CDC42 36
  • 80 (a)
OneToMany
CDC42 38
rice
(Oryza sativa)
Liliopsida Os01g0229400 35
  • 51.47 (n)
  • 53.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11608 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06454 35
  • 65.61 (n)
  • 79.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc42 35
  • 69.28 (n)
  • 82.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7317 36
  • 78 (a)
OneToOne
Species with no ortholog for CDC42:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC42 Gene

ENSEMBL:
Gene Tree for CDC42 (if available)
TreeFam:
Gene Tree for CDC42 (if available)

Paralogs for CDC42 Gene

Paralogs for CDC42 Gene

genes like me logo Genes that share paralogs with CDC42: view

Variants for CDC42 Gene

Sequence variations from dbSNP and Humsavar for CDC42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs722697 -- 22,093,266(-) GCTTT(C/T)CAATG downstream-variant-500B
rs763442 -- 22,089,448(-) CTCTA(A/G)AAACA intron-variant
rs767399 -- 22,082,284(+) AAGGC(A/G)TATTC intron-variant
rs909821 -- 22,060,378(-) CCACA(A/T)GGAGT intron-variant
rs1016493 -- 22,077,685(-) CATGT(A/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC42 Gene

Variant ID Type Subtype PubMed ID
dgv43e1 CNV Complex 17122850
nsv834413 CNV Loss 17160897
nsv528664 CNV Gain 19592680
nsv871778 CNV Gain 21882294
nsv6076 CNV Insertion 18451855

Variation tolerance for CDC42 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC42 Gene

Human Gene Mutation Database (HGMD)
CDC42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC42 Gene

Disorders for CDC42 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CDC42 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
shigellosis
  • bacillary dysentery
aarskog-scott syndrome
  • aarskog syndrome
xeroderma pigmentosum, group b
  • xeroderma pigmentosum complementation group b
subcutaneous mycosis
  • subcutaneous fungal disease
- elite association - COSMIC cancer census association via MalaCards
Search CDC42 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC42

Genetic Association Database (GAD)
CDC42
Human Genome Epidemiology (HuGE) Navigator
CDC42
Tumor Gene Database (TGDB):
CDC42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC42
genes like me logo Genes that share disorders with CDC42: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC42 Gene

Publications for CDC42 Gene

  1. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. (PMID: 2124704) Shinjo K. … Cerione R.A. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts. (PMID: 20067638) Appledorn D.M. … McCormick J.J. (BMC Cancer 2010) 3 23
  3. Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state. (PMID: 20130240) Stabile H. … Gismondi A. (Blood 2010) 3 23
  4. Dual role of Cdc42 in spindle orientation control of adherent cells. (PMID: 19273597) Mitsushima M. … Nishida E. (Mol. Cell. Biol. 2009) 3 23
  5. Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42. (PMID: 19356586) Kintscher C. … Groemping Y. (J. Mol. Biol. 2009) 3 23

Products for CDC42 Gene

Sources for CDC42 Gene

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