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CDC42 Gene

protein-coding   GIFtS: 75
GCID: GC01P022379

Cell Division Cycle 42

(Previous names: cell division cycle 42 (GTP-binding protein, 25kD), cell...)
  See CDC42-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 421 2     Cell Division Control Protein 42 Homolog2
G25K GTP-Binding Protein2 3     DJ224A6.1.1 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
25kDa1     DJ224A6.1.2 (Cell Division Cycle 42 (GTP-Binding Protein, 25kD))2
Cell Division Cycle 42 (GTP Binding Protein, 25kDa)1     Growth-Regulating Protein2
Cell Division Cycle 42 (GTP-Binding Protein, 25kD)1     GTP Binding Protein, 25kDa2
GTP Binding Protein1     GTP-Binding Protein, 25kD2
CDC42Hs2     Small GTP Binding Protein CDC422
G25K2     

External Ids:    HGNC: 17361   Entrez Gene: 9982   Ensembl: ENSG000000708317   OMIM: 1169525   UniProtKB: P609533   

Export aliases for CDC42 gene to outside databases

Previous GC identifers: GC01P021948 GC01P021414 GC01P021525 GC01P021848 GC01P021991 GC01P022235 GC01P020622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC42 Gene:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that
control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression.
This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1
mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this
protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich
syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results
in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and
20. (provided by RefSeq, Apr 2013)

GeneCards Summary for CDC42 Gene:
CDC42 (cell division cycle 42) is a protein-coding gene. Diseases associated with CDC42 include noma, and wiskott-aldrich syndrome. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved
in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to
kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the
formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration

Gene Wiki entry for CDC42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC42 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDC42 promoter sequence
   Search Chromatin IP Primers for CDC42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1

CDC42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC42 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022379:  view genomic region     (about GC identifiers)

Start:
22,379,120 bp from pter      End:
22,419,437 bp from pter
Size:
40,318 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953 (See protein sequence)
Recommended Name: Cell division control protein 42 homolog precursor  
Size: 191 amino acids; 21259 Da
Subunit: The GTP-bound form interacts with CCPG1 (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3,
CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with
activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by
exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B
and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by
the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration
composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction
inactivates and stabilizes CDC42
Selected PDB 3D structures from and Proteopedia for CDC42 (see all 29):
1A4R (3D)        1AJE (3D)        1AM4 (3D)        1AN0 (3D)        1CEE (3D)        1CF4 (3D)    
Secondary accessions: P21181 P25763 Q7L8R5 Q9UDI2
Alternative splicing: 2 isoforms:  P60953-2, P21181-4   P60953-1, P21181-1   

Explore the universe of human proteins at neXtProt for CDC42: NX_P60953

Explore proteomics data for CDC42 at MOPED

Post-translational modifications: 

  • AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and
    V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the
    GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in
    infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but
    additional experiments remain to be done to confirm results in vivo1
  • Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation
    inhibitor RhoGDI1
  • Ubiquitination2 at Lys107, Lys133, Lys135, Lys144
  • Modification sites at PhosphoSitePlus

  • See CDC42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034891.1  NP_001782.1  NP_426359.1  

    ENSEMBL proteins: 
     ENSP00000341072   ENSP00000314458   ENSP00000398327   ENSP00000383118   ENSP00000398592  
    Reactome Protein details: P60953

    CDC42 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDC42 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CDC42
    OriGene Protein Over-expression Lysate for CDC42
    OriGene MassSpec for CDC42
    OriGene Custom Protein Services for CDC42
    GenScript Custom Purified and Recombinant Proteins Services for CDC42
    Novus Biologicals CDC42 Proteins
    Novus Biologicals CDC42 Lysates
    Sino Biological Recombinant Protein for CDC42
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDC42
    Cloud-Clone Corp. Proteins for CDC42

     
    Search eBioscience for Proteins for CDC42 

    CDC42 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC42
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDC42 
    OriGene Antibodies for CDC42
    OriGene Custom Antibody Services for CDC42
    Novus Biologicals CDC42 Antibodies
    Abcam antibodies for CDC42 (P60953, P17081)
    Cloud-Clone Corp. Antibodies for CDC42
    ThermoFisher Antibody for CDC42
    LSBio Antibodies in human, mouse, rat for CDC42

    CDC42 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CDC42
    OriGene Custom Assay Services for CDC42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDC42
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC42
    Cloud-Clone Corp. CLIAs for CDC42
    Search eBioscience for ELISAs for CDC42 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P60953

    ProtoNet protein and cluster: P60953

    3 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: CDC42_HUMAN, P60953
    Similarity: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily


    Find genes that share domains with CDC42           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC42_HUMAN, P60953
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
    GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved
    in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to
    kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the
    formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP
    for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase

         Genatlas biochemistry entry for CDC42:
    GTP binding protein 25k,homolog to yeast cdc42,brain,isoform,promoting cell cycle progression from G1 to
    S,activating the Jun N-terminal kinase/stress activated protein kinase required for cell polarization,stimulating
    the actin-depolymerizing activity of WASL,regulating in cooperation with WASP podosomeal adhesion structure in
    primary macrophages

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS11035016
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0019901protein kinase binding IPI--
    GO:0030742GTP-dependent protein binding IEA--
         
    Find genes that share ontologies with CDC42           About GenesLikeMe


    Phenotypes:
         10 GenomeRNAi human phenotypes for CDC42:
     Decreased Hepatitis C virus re  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Increased S DNA content  Increased cell elongation, dec 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cdc42) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with CDC42           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdc42tm1Fwa for CDC42

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC42
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC42
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC42

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC42:
    hsa-mir-29b-3p (MIRT006488), hsa-mir-608 (MIRT005966), hsa-mir-185-5p (MIRT004037), hsa-mir-375 (MIRT019885), hsa-mir-484 (MIRT041813), hsa-mir-29a-3p (MIRT006490), hsa-mir-195-5p (MIRT006995), hsa-mir-330-3p (MIRT005965), hsa-mir-224-5p (MIRT000636), hsa-mir-106b-5p (MIRT044369), hsa-mir-93-3p (MIRT038837), hsa-mir-137 (MIRT005485), hsa-mir-216a-5p (MIRT005964), hsa-mir-1 (MIRT023726), hsa-mir-29c-3p (MIRT006489)

    Block miRNA regulation of human, mouse, rat CDC42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCDC42 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC42
    Predesigned siRNA for gene silencing in human, mouse, rat CDC42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC42

    Clone
    Products:
         
    OriGene clones in human, mouse for CDC42 (see all 16)
    OriGene ORF clones in mouse, rat for CDC42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC42 (NM_001791)
    Sino Biological Human cDNA Clone for CDC42
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42
    Addgene plasmids for CDC42 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDC42
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC42 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12287) for CDC42 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC42_HUMAN, P60953: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle
    during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase.
    Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its
    localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating
    protein RACGAP1. Colocalizes with NEK6 in the centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    golgi apparatus3
    endosome2
    extracellular2
    nucleus2
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11260256
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDC42           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC42 About   (see all 125)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    3Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    VEGF signaling pathway0.39
    4Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Cytoskeleton remodeling FAK signaling0.41
    5Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57


    Find genes that share SuperPaths with CDC42           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CDC42
        VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC42 (see all 56)
        Fc-GammaR Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for CDC42
        MAP Kinase Signaling
    Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for CDC42 (see all 29)
        Development A2A receptor signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD16 signaling in NK cells

    Selected BioSystems Pathways for CDC42 (see all 38)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    TOR signaling
    EGFR1 Signaling Pathway

    2 Sino Biological Pathways for CDC42
        Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for CDC42 (see all 11)
        CD28 dependent Vav1 pathway
    G alpha (12/13) signalling events
    Rho GTPase cycle
    GPVI-mediated activation cascade
    EGFR downregulation

    1 PharmGKB Pathway for CDC42
        Bisphosphonate Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CDC42) (see all 27):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Endocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC42 (see all 13): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC42 (P609531, 2, 3 ENSP000003144584) via UniProtKB, MINT, STRING, and/or I2D (see all 559)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469401, 2, 3, ENSP000002681824EBI-81752,EBI-297509 MINT-14955 MINT-18637 MINT-18638 MINT-14956 MINT-14954 MINT-16570 MINT-18639 I2D: score=5 STRING: ENSP00000268182
    PAK1Q131531, 2, 3, ENSP000002785684EBI-81752,EBI-1307 MINT-24772 MINT-14490 MINT-7217629 MINT-8078125 MINT-14030 MINT-14489 I2D: score=10 STRING: ENSP00000278568
    WASP427681, 2, 3, ENSP000003658914EBI-81752,EBI-346375 MINT-13944 MINT-13945 MINT-25018 I2D: score=9 STRING: ENSP00000365891
    TRIP10Q156422, 3, ENSP000003204934MINT-15379 MINT-50937 I2D: score=3 STRING: ENSP00000320493
    CDC42EP1Q005871, 3, ENSP000002490144EBI-81752,EBI-744130 I2D: score=6 STRING: ENSP00000249014
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002040sprouting angiogenesis IEA--
    GO:0003161cardiac conduction system development IEA--
    GO:0003334keratinocyte development IEA--
    GO:0006184GTP catabolic process TAS11035016

    Find genes that share ontologies with CDC42           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC42

    3 HMDB Compounds for CDC42    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for CDC42    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminophosphonic Acid-Guanylate Ester-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CDC42 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskostatin 81.9 1 19741094 (1)
    gdp 78.6 74 1429634 (7), 12369824 (4), 18348980 (4), 7918454 (3) (see all 31)
    gtp 76 138 12369824 (5), 8605211 (4), 16784226 (4), 7918454 (4) (see all 55)
    mdi-a 71.6 3 18829452 (1), 18239683 (1), 12445462 (1)
    mant-gdp 64.6 5 8626553 (4)
    phosphatidylinositol 61.3 42 12551955 (4), 15557338 (3), 10793146 (2), 15133042 (2) (see all 24)
    tyrosine 56 49 10587647 (3), 15485841 (2), 10713072 (2), 7542236 (2) (see all 33)
    guanosine 55.3 9 10893268 (2), 8253717 (1), 11371639 (1), 9571239 (1) (see all 8)
    threonine 51.2 25 10947843 (3), 9687501 (1), 11058583 (1), 9683637 (1) (see all 20)
    serine 43.7 22 9687501 (1), 11058583 (1), 9683637 (1), 9760238 (1) (see all 19)



    Find genes that share compounds with CDC42           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC42 gene (3 alternative transcripts): 
    NM_001039802.1  NM_001791.3  NM_044472.2  

    Unigene Cluster for CDC42:

    Cell division cycle 42
    Hs.467637  [show with all ESTs]
    Unigene Representative Sequence: NM_001039802
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344548(uc009vqg.1 uc001bfq.3) ENST00000315554(uc001bfp.3)
    ENST00000498236 ENST00000411827 ENST00000400259(uc001bfr.3 uc010odr.2 uc010ods.2 uc009vqh.3)
    ENST00000421089
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDC42 (see all 41):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-15a hsa-miR-25 hsa-miR-139-5p hsa-miR-570 hsa-miR-374c hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCDC42 3' UTR sequence
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    OriGene ORF clones in mouse, rat for CDC42
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDC42 (NM_001791)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC42
    Addgene plasmids for CDC42 
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      QuantiFast Probe-based Assays in human, mouse, rat CDC42
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    eBioscience FlowRNA Probe Sets ( VA1-12287) for CDC42 

    Additional mRNA sequence: 

    AF498962.1 AF498963.1 AK297465.1 AK303994.1 AK311375.1 AK316449.1 AL121734.1 AL121735.1 
    AL121736.1 AL121737.1 BC002711.2 BC003682.1 BC018266.1 BC018622.1 M35543.1 M57298.1 

    Selected DOTS entries (see all 35):

    DT.454483  DT.99994472  DT.92457205  DT.100845422  DT.100657929  DT.92457158  DT.121231254  DT.97860521 
    DT.100038646  DT.100733144  DT.99949776  DT.95172212  DT.100845424  DT.92457170  DT.121231272  DT.100038647 
    DT.95172226  DT.121330805  DT.420370  DT.95172215  DT.100733143  DT.95172227  DT.100684047  DT.100845415 

    Selected AceView cDNA sequences (see all 806):

    CA311415 BM806119 BU951281 AI887582 BQ575387 CB243569 CR601442 F12009 
    AA903625 AA863455 BM835345 AA627482 AI373789 AA236216 BU580864 AI092444 
    BQ424918 BP871888 AA314298 BQ938153 AA843430 F08957 CA307354 AA009697 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAATTCT
    CDC42 Expression
    About this image


    CDC42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Epithelial Cells
             Duct Progenitor Cells Ventral Pancreatic Bud
    CDC42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467637
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC42 (see all 13): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC42 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc425 cell division cycle 42 homolog (S. cerevisiae)   --   4 (69.83 cM) 137319696 
    chicken
    (Gallus gallus)
    Aves CDC421 cell division cycle 42 (GTP binding protein, 25kDa) 88.48(n)
    99.48(a)
      395917  NM_205048.1  NP_990379.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC426
    cell division cycle 42
    100(a)
    1 ↔ 1
    AAWZ02040513(4686-6853)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC526192 similar to cell division cycle 42 homolog (S. cerevisiae) 83.77(n)    AF275252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639182 hypothetical protein MGC63918 83.19(n)   393605  BC057415.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdc421 , 3 axon guidance GTPase3
    Cdc421
    92(a)
    (best of 3)3
    72.43(n)1
    92.67(a)1
      18E13
    329811  NM_001258835.11  NP_001245764.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-421 , 3 RAS protein3
    cdc-421
    86(a)
    (best of 4)3
    71.9(n)1
    86.39(a)1
      II(7616169-7617803)3
    1742331  NM_063197.71  NP_495598.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC42(YLR229C)4
    CDC421
    Small rho-like GTPase, essential for establishment more4
    CDC421
    68.41(n)1
    80.1(a)1
      12(604787-604212)4
    8509301, 4  NP_013330.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os01g02294001 Os01g0229400 51.47(n)
    53.3(a)
      4325879  NM_001049021.1  NP_001042486.1 


    ENSEMBL Gene Tree for CDC42 (if available)
    TreeFam Gene Tree for CDC42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC42 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  
    RAC22  RHOJ2  RAC32  
    Selected SIMAP similar genes for CDC42 using alignment to 3 protein entries:     CDC42_HUMAN (see all proteins) (see all similar genes):
    RHOJ    RAC2    RAC3    RHOQ    RAC1    ARHG
    RHOG    RHOU    RHOV    RHOC    RHOD    RHOB
    RHOF    RHOA    RHOH    ARHA    ARHH    ARHE

    Find genes that share paralogs with CDC42           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CDC42 (see all 7)
    PGOHUM00000247518 PGOHUM00000246022 PGOHUM00000235456 PGOHUM00000232697 PGOHUM00000232711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC42 (see all 958)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178379991,2
    C,F--20627876(+) TCTATGT/-TGGTC 3 -- int12Minor allele frequency- -:0.12NS NA 172
    rs749419571,2
    C,F--22377142(+) GGGTGC/TGGTGG 3 -- us2k12Minor allele frequency- T:0.13NA EA 240
    rs1915442311,2
    --22377241(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs75119341,2
    A--22377269(+) ttagcC/Tgggca 3 -- us2k10--------
    rs75119441,2
    A--22377305(+) ccactC/Tgggag 3 -- us2k10--------
    rs1113439461,2
    C--22377338(+) AACCCA/G/TGGAGG 3 -- us2k10--------
    rs75545781,2
    C--22377349(+) cggagA/C/Gttgca 3 -- us2k13NA WA 6
    rs1915157041,2
    --22377362(+) GAGCCA/GAGATC 3 -- us2k10--------
    rs764149531,2
    C--22377412(+) CGTCTA/CAAAAA 3 -- us2k10--------
    rs124036471,2
    C,H--22377491(+) AAATAG/ACTGTG 3 -- us2k14Minor allele frequency- A:0.00NS EA 406

    HapMap Linkage Disequilibrium report for CDC42 (22379120 - 22419437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDC42:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6076CNV Insertion18451855
    nsv834413CNV Loss17160897
    nsv528664CNV Gain19592680
    nsv871778CNV Gain21882294
    dgv43e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CDC42
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CDC42:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CDC42
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116952    OMIM disorders: --

    4 diseases for CDC42:    
    About MalaCards
    noma    wiskott-aldrich syndrome    aarskog-scott syndrome    scott syndrome

    4 diseases from the University of Copenhagen DISEASES database for CDC42:
    Aarskog-Scott syndrome     Wiskott-Aldrich syndrome     Cancer     Myotonic dystrophy

    Find genes that share disorders with CDC42           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDC42 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 83.2 28 15456777 (2), 19741094 (2), 15102814 (2), 10950951 (2) (see all 20)
    temperature-sensitive lethal mutation 60.3 1 2122236 (1)
    metastasis 23.2 10 17970806 (2), 18728402 (2), 20305651 (1), 18044786 (1) (see all 6)
    cancer 9.32 13 17971488 (4), 19416857 (2), 20067638 (2), 16540523 (1) (see all 8)
    tumors 8.58 43 17027002 (5), 12482591 (2), 20067638 (2), 15269155 (2) (see all 23)
    familial adenomatous polyposis 8.35 2 17085436 (1), 15890984 (1)
    dysplasia 8.27 2 9268645 (1), 19261807 (1)
    hypertrophy 4.52 1 11158304 (1)
    pneumonia 3.76 1 15574879 (1)
    adenocarcinoma 2.84 2 18575765 (2)

    Genetic Association Database (GAD): CDC42
    Human Genome Epidemiology (HuGE) Navigator: CDC42 (9 documents)
    Tumor Gene Database (TGDB): CDC42

    Export disorders for CDC42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC42 gene, integrated from 10 sources (see all 982):
    (articles sorted by number of sources associating them with CDC42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. (PubMed id 2122236)1, 2, 3, 9 Munemitsu S....Polakis P. (Mol. Cell. Biol. 1990)
    2. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. (PubMed id 2124704)1, 2, 3 Shinjo K.... Cerione R.A. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Identification of the binding surface on Cdc42Hs for p21-activated kinase. (PubMed id 9760238)1, 2, 9 Guo W.... Oswald R.E. (Biochemistry 1998)
    4. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2, 9 Masuda-Robens J.M.... Chou M.M. (Mol. Cell. Biol. 2003)
    5. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2, 9 Eisenmann K.M.... Iida J. (Nat. Cell Biol. 1999)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (PLoS ONE 2010)
    8. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    9. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (PubMed id 19039103)1, 2 Yarbrough M.L.... Orth K. (Science 2009)
    10. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PubMed id 19667218)1, 4 Comabella M....Montalban X. (Arch. Neurol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 998 HGNC: 1736 AceView: CDC42 Ensembl:ENSG00000070831 euGenes: HUgn998
    ECgene: CDC42 Kegg: 998 H-InvDB: CDC42

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC42 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC42 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc42/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC42 gene:
    Search GeneIP for patents involving CDC42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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