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Aliases for CDC40 Gene

Aliases for CDC40 Gene

  • Cell Division Cycle 40 2 3
  • PRP17 3 4 6
  • Cell Division Cycle 40 Homolog 3 4
  • EH-Binding Protein 3 3 4
  • PRP17 Homolog 3 4
  • PRPF17 3 4
  • HPRP17 3 4
  • EHB3 3 4
  • Cell Division Cycle 40 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 40 Homolog (Yeast) 2
  • Pre-MRNA-Processing Factor 17 3
  • Pre-MRNA Splicing Factor 17 3

External Ids for CDC40 Gene

Previous GeneCards Identifiers for CDC40 Gene

  • GC06P110501
  • GC06P110547
  • GC06P110608
  • GC06P108068

Summaries for CDC40 Gene

Entrez Gene Summary for CDC40 Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC40 Gene

CDC40 (Cell Division Cycle 40) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. An important paralog of this gene is WDR25.

UniProtKB/Swiss-Prot for CDC40 Gene

  • Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.

Gene Wiki entry for CDC40 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC40 Gene

Genomics for CDC40 Gene

Regulatory Elements for CDC40 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC40 Gene

Start:
110,180,141 bp from pter
End:
110,254,275 bp from pter
Size:
74,135 bases
Orientation:
Plus strand

Genomic View for CDC40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC40 Gene

Proteins for CDC40 Gene

  • Protein details for CDC40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60508-PRP17_HUMAN
    Recommended name:
    Pre-mRNA-processing factor 17
    Protein Accession:
    O60508
    Secondary Accessions:
    • B2RBC5
    • O75471
    • Q5SRN0
    • Q9UPG1

    Protein attributes for CDC40 Gene

    Size:
    579 amino acids
    Molecular mass:
    65521 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=AAC25166.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDC40 Gene

Proteomics data for CDC40 Gene at MOPED

Post-translational modifications for CDC40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC40 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC40 Gene

Domains for CDC40 Gene

Gene Families for CDC40 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

O60508

UniProtKB/Swiss-Prot:

PRP17_HUMAN :
  • O60508
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CDC40: view

Function for CDC40 Gene

Molecular function for CDC40 Gene

UniProtKB/Swiss-Prot Function: Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for CDC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CDC40: view
genes like me logo Genes that share phenotypes with CDC40: view

Animal Model Products

CRISPR Products

miRNA for CDC40 Gene

miRTarBase miRNAs that target CDC40

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC40

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC40 Gene

Localization for CDC40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC40 Gene COMPARTMENTS Subcellular localization image for CDC40 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex TAS 9524131
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with CDC40: view

Pathways for CDC40 Gene

genes like me logo Genes that share pathways with CDC40: view

Gene Ontology (GO) - Biological Process for CDC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with CDC40: view

Transcripts for CDC40 Gene

Unigene Clusters for CDC40 Gene

Cell division cycle 40:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC40

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CDC40

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC40 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -
SP3:

Relevant External Links for CDC40 Gene

GeneLoc Exon Structure for
CDC40
ECgene alternative splicing isoforms for
CDC40

Expression for CDC40 Gene

mRNA expression in normal human tissues for CDC40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC40 Gene

SOURCE GeneReport for Unigene cluster for CDC40 Gene Hs.428147

genes like me logo Genes that share expressions with CDC40: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC40 Gene

Orthologs for CDC40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC40 35
  • 99.88 (n)
  • 100 (a)
CDC40 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC40 35
  • 95.22 (n)
  • 98.27 (a)
CDC40 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC40 35
  • 94.13 (n)
  • 98.45 (a)
CDC40 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc40 35
  • 91.82 (n)
  • 98.79 (a)
Cdc40 16
Cdc40 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC40 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC40 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc40 35
  • 90.02 (n)
  • 99.1 (a)
chicken
(Gallus gallus)
Aves CDC40 35
  • 81.72 (n)
  • 92.69 (a)
CDC40 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25695 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc40 35
  • 78.94 (n)
  • 89.93 (a)
Str.2081 35
zebrafish
(Danio rerio)
Actinopterygii cdc40 35
  • 72.54 (n)
  • 85.32 (a)
cdc40 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008925 35
  • 59.68 (n)
  • 63.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6015 35
  • 59.45 (n)
  • 62.94 (a)
CG6015 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prp-17 35
  • 57.89 (n)
  • 52.3 (a)
prp-17 36
  • 50 (a)
OneToMany
Y54G2A.12 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 36
  • 36 (a)
OneToMany
CDC40 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10580 35
  • 57.9 (n)
  • 55.81 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5314 35
rice
(Oryza sativa)
Liliopsida Os03g0397500 35
  • 53.64 (n)
  • 53.51 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28744 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06921 35
  • 49.79 (n)
  • 44.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp17 35
  • 52.19 (n)
  • 45.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7893 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
CSA.6770 36
  • 38 (a)
OneToMany
Species with no ortholog for CDC40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDC40 Gene

ENSEMBL:
Gene Tree for CDC40 (if available)
TreeFam:
Gene Tree for CDC40 (if available)

Paralogs for CDC40 Gene

Paralogs for CDC40 Gene

Selected SIMAP similar genes for CDC40 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDC40: view

Variants for CDC40 Gene

Sequence variations from dbSNP and Humsavar for CDC40 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1140054 -- 110,231,487(+) agagc(A/G)agact utr-variant-3-prime
rs4339500 -- 110,190,611(+) TAGTA(A/G)GCAGT intron-variant
rs4343947 -- 110,199,363(+) GGCAG(A/G)GGCGG intron-variant
rs4421235 -- 110,211,123(+) TTGGT(A/G)TATTA intron-variant
rs4509164 -- 110,198,954(+) TGAGA(A/G)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC40 Gene

Variant ID Type Subtype PubMed ID
nsv886535 CNV Loss 21882294
dgv2001e1 CNV Complex 17122850
nsv886536 CNV Loss 21882294
nsv5439 CNV Insertion 18451855

Relevant External Links for CDC40 Gene

HapMap Linkage Disequilibrium report
CDC40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC40 Gene

Disorders for CDC40 Gene

Relevant External Links for CDC40

Genetic Association Database (GAD)
CDC40
Human Genome Epidemiology (HuGE) Navigator
CDC40
genes like me logo Genes that share disorders with CDC40: view

No data available for UniProtKB/Swiss-Prot for CDC40 Gene

Publications for CDC40 Gene

  1. Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. (PMID: 9769104) Ben-Yehuda S. … Kupiec M. (RNA 1998) 2 3 4 23
  2. Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. (PMID: 9830021) Lindsey L.A. … Garcia-Blanco M.A. (J. Biol. Chem. 1998) 2 3 4
  3. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PMID: 9303539) Salcini A.E. … Di Fiore P.P. (Genes Dev. 1997) 3 4
  4. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PMID: 9524131) Zhou Z. … Reed R. (EMBO J. 1998) 3 4
  5. Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors. (PMID: 19420964) Miyaki M. … Mori T. (Oncology 2009) 3 48

Products for CDC40 Gene

Sources for CDC40 Gene

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