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Aliases for CDC40 Gene

Aliases for CDC40 Gene

  • Cell Division Cycle 40 2 3 5
  • Cell Division Cycle 40 Homolog 3 4
  • EH-Binding Protein 3 3 4
  • PRP17 Homolog 3 4
  • PRPF17 3 4
  • HPRP17 3 4
  • PRP17 3 4
  • EHB3 3 4
  • Cell Division Cycle 40 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 40 Homolog (Yeast) 2
  • Pre-MRNA Splicing Factor 17 3

External Ids for CDC40 Gene

Previous GeneCards Identifiers for CDC40 Gene

  • GC06P110501
  • GC06P110547
  • GC06P110608
  • GC06P108068

Summaries for CDC40 Gene

Entrez Gene Summary for CDC40 Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC40 Gene

CDC40 (Cell Division Cycle 40) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is WDR25.

UniProtKB/Swiss-Prot for CDC40 Gene

  • Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.

Gene Wiki entry for CDC40 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC40 Gene

Genomics for CDC40 Gene

Regulatory Elements for CDC40 Gene

Enhancers for CDC40 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC40 on UCSC Golden Path with GeneCards custom track

Promoters for CDC40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC40 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC40 Gene

110,180,141 bp from pter
110,254,275 bp from pter
74,135 bases
Plus strand

Genomic View for CDC40 Gene

Genes around CDC40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC40 Gene

Proteins for CDC40 Gene

  • Protein details for CDC40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-processing factor 17
    Protein Accession:
    Secondary Accessions:
    • B2RBC5
    • O75471
    • Q5SRN0
    • Q9UPG1

    Protein attributes for CDC40 Gene

    579 amino acids
    Molecular mass:
    65521 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Sequence=AAC25166.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CDC40 Gene

Proteomics data for CDC40 Gene at MOPED

Post-translational modifications for CDC40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC40 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC40 Gene

Domains & Families for CDC40 Gene

Gene Families for CDC40 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 WD repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CDC40: view

Function for CDC40 Gene

Molecular function for CDC40 Gene

UniProtKB/Swiss-Prot Function:
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
genes like me logo Genes that share phenotypes with CDC40: view

Animal Model Products

miRNA for CDC40 Gene

miRTarBase miRNAs that target CDC40

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC40 Gene

Localization for CDC40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC40 Gene

Subcellular locations from

Jensen Localization Image for CDC40 Gene COMPARTMENTS Subcellular localization image for CDC40 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CDC40: view

Pathways & Interactions for CDC40 Gene

genes like me logo Genes that share pathways with CDC40: view

Pathways by source for CDC40 Gene

1 KEGG pathway for CDC40 Gene

Gene Ontology (GO) - Biological Process for CDC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing TAS 9524131
genes like me logo Genes that share ontologies with CDC40: view

No data available for SIGNOR curated interactions for CDC40 Gene

Drugs & Compounds for CDC40 Gene

No Compound Related Data Available

Transcripts for CDC40 Gene

Unigene Clusters for CDC40 Gene

Cell division cycle 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC40 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -

Relevant External Links for CDC40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC40 Gene

mRNA expression in normal human tissues for CDC40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDC40 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.1) and Monocytes (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC40 Gene

SOURCE GeneReport for Unigene cluster for CDC40 Gene Hs.428147

genes like me logo Genes that share expression patterns with CDC40: view

Protein tissue co-expression partners for CDC40 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC40 Gene

Orthologs for CDC40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC40 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC40 35
  • 95.22 (n)
  • 98.27 (a)
CDC40 36
  • 98 (a)
(Canis familiaris)
Mammalia CDC40 35
  • 94.13 (n)
  • 98.45 (a)
CDC40 36
  • 86 (a)
(Mus musculus)
Mammalia Cdc40 35
  • 91.82 (n)
  • 98.79 (a)
Cdc40 16
Cdc40 36
  • 99 (a)
(Pan troglodytes)
Mammalia CDC40 35
  • 99.88 (n)
  • 100 (a)
CDC40 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdc40 35
  • 90.02 (n)
  • 99.1 (a)
(Monodelphis domestica)
Mammalia CDC40 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CDC40 36
  • 96 (a)
(Gallus gallus)
Aves CDC40 35
  • 81.72 (n)
  • 92.69 (a)
CDC40 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
-- 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc40 35
  • 78.94 (n)
  • 89.93 (a)
Str.2081 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25695 35
(Danio rerio)
Actinopterygii cdc40 35
  • 72.54 (n)
  • 85.32 (a)
cdc40 36
  • 83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008925 35
  • 59.68 (n)
  • 63.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6015 35
  • 59.45 (n)
  • 62.94 (a)
CG6015 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea prp-17 35
  • 57.89 (n)
  • 52.3 (a)
prp-17 36
  • 50 (a)
Y54G2A.12 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC40 36
  • 36 (a)
CDC40 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10580 35
  • 57.9 (n)
  • 55.81 (a)
(Hordeum vulgare)
Liliopsida Hv.5314 35
(Oryza sativa)
Liliopsida Os03g0397500 35
  • 53.64 (n)
  • 53.51 (a)
(Triticum aestivum)
Liliopsida Ta.28744 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7893 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06921 35
  • 49.79 (n)
  • 44.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp17 35
  • 52.19 (n)
  • 45.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
CSA.6770 36
  • 38 (a)
Species with no ortholog for CDC40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDC40 Gene

Gene Tree for CDC40 (if available)
Gene Tree for CDC40 (if available)

Paralogs for CDC40 Gene

Paralogs for CDC40 Gene

(3) SIMAP similar genes for CDC40 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDC40: view

Variants for CDC40 Gene

Sequence variations from dbSNP and Humsavar for CDC40 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1140054 -- 110,231,487(+) agagc(A/G)agact utr-variant-3-prime
rs4947058 -- 110,216,482(+) TCTCC(A/G)TCAGA intron-variant
rs9487314 -- 110,203,785(+) GACTT(C/G)TCAGC intron-variant
rs9487315 -- 110,220,681(+) acctt(A/G)tgatc intron-variant
rs9487316 -- 110,220,780(+) GAGAG(A/G)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC40 Gene

Variant ID Type Subtype PubMed ID
nsv886535 CNV Loss 21882294
dgv2001e1 CNV Complex 17122850
nsv886536 CNV Loss 21882294
nsv5439 CNV Insertion 18451855

Variation tolerance for CDC40 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDC40 Gene

Disorders for CDC40 Gene

Relevant External Links for CDC40

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDC40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC40 Gene

Publications for CDC40 Gene

  1. Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. (PMID: 9769104) Ben-Yehuda S. … Kupiec M. (RNA 1998) 2 3 4 23 67
  2. Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. (PMID: 9830021) Lindsey L.A. … Garcia-Blanco M.A. (J. Biol. Chem. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CDC40 Gene

Sources for CDC40 Gene