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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC40 Gene

protein-coding   GIFtS: 61
GCID: GC06P110547

Cell Division Cycle 40

(Previous names: cell division cycle 40 homolog (yeast), cell division cycle...)
  Search for CDC40
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 401 2     PRP17 Homolog2 3
PRP172 3 5     Cell Division Cycle 40 Homolog (S. Cerevisiae)1
Cell Division Cycle 40 Homolog2 3     Cell Division Cycle 40 Homolog (Yeast)1
EHB32 3     Pre-MRNA Splicing Factor 172
PRPF172 3     Pre-MRNA-Processing Factor 172
EH-Binding Protein 32 3     Ehb33
hPRP172 3     

External Ids:    HGNC: 173501   Entrez Gene: 513622   Ensembl: ENSG000001684387   OMIM: 6055855   UniProtKB: O605083   

Export aliases for CDC40 gene to outside databases

Previous GC identifers: GC06P110501 GC06P110608 GC06P108068


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC40 Gene:
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to
be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains
seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast
Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression.
It suggests that this protein may play a role in cell cycle progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC40 Gene: 
CDC40 (cell division cycle 40) is a protein-coding gene. Among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. An important paralog of this gene is WDR25.

UniProtKB/Swiss-Prot: PRP17_HUMAN, O60508
Function: Associates with the spliceosome late in the splicing pathway and may function in the second step of
pre-mRNA splicing

Gene Wiki entry for CDC40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC40 gene promoter:
         HFH-3   Nkx2-5   Evi-1   AREB6   FOXI1   S8   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC40 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22.1

CDC40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC40 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P110547:  view genomic region     (about GC identifiers)

Start:
110,501,344 bp from pter      End:
110,575,478 bp from pter
Size:
74,135 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRP17_HUMAN, O60508 (See protein sequence)
Recommended Name: Pre-mRNA-processing factor 17  
Size: 579 amino acids; 65521 Da
Subunit: Identified in the spliceosome C complex
Subcellular location: Nucleus
Sequence caution: Sequence=AAC25166.1; Type=Erroneous initiation;
Secondary accessions: B2RBC5 O75471 Q5SRN0 Q9UPG1

Explore the universe of human proteins at neXtProt for CDC40: NX_O60508

Explore proteomics data for CDC40 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60508

  • CDC40 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC40 Protein Expression
    REFSEQ proteins: NP_056975.1  
    ENSEMBL proteins: 
     ENSP00000357928   ENSP00000357929   ENSP00000357926   ENSP00000304370  
    Reactome Protein details: O60508
    Human Recombinant Protein Products for CDC40: 
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    Novus Biologicals CDC40 Proteins
    Novus Biologicals CDC40 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC40 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS9524131
    GO:0071013catalytic step 2 spliceosome IDA11991638

    CDC40 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CDC40


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O60508

    ProtoNet protein and cluster: O60508

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: PRP17_HUMAN, O60508
    Similarity: Contains 7 WD repeats


    CDC40 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP17_HUMAN, O60508
    Function: Associates with the spliceosome late in the splicing pathway and may function in the second step of
    pre-mRNA splicing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CDC40 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDC40:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDC40 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDC40

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC40 
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    SwitchGear 3'UTR luciferase reporter plasmidCDC40 3' UTR sequence
    Inhib. RNA
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC40 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CDC40
        mRNA processing


    5/14        Reactome Pathways for CDC40 (see all 14)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    1         Kegg Pathway  (Kegg details for CDC40):
        Spliceosome


    CDC40 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/211 Interacting proteins for CDC40 (O605082, 3 ENSP000003043704) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF19Q9UMS42, ENSP000002275244MINT-8331613 MINT-8336738 STRING: ENSP00000227524
    SMAD2Q157963, ENSP000002621604I2D: score=4 STRING: ENSP00000262160
    NCBP2P522983, ENSP000003268064I2D: score=2 STRING: ENSP00000326806
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    SNRNP200O756433, ENSP000003171234I2D: score=2 STRING: ENSP00000317123
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0008380RNA splicing TAS--

    CDC40 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC40 (PRP17)

    Search CenterWatch for drugs/clinical trials and news about CDC40 / PRP17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC40 gene: 
    NM_015891.2  

    Unigene Cluster for CDC40:

    Cell division cycle 40
    Hs.428147  [show with all ESTs]
    Unigene Representative Sequence: NM_015891
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606893 ENST00000368932(uc003pua.3) ENST00000368933 ENST00000368930
    ENST00000453107 ENST00000431461 ENST00000445340 ENST00000307731
    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-3916 hsa-miR-372 hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC40 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC40
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC40

    Additional mRNA sequence: 

    AB208903.1 AF015044.1 AF038392.1 AF061241.1 AK001426.1 AK222721.1 AK295055.1 AK314601.1 
    BC111061.1 BC117145.1 BC126114.1 

    12 DOTS entries:

    DT.455982  DT.100766229  DT.99983647  DT.99994564  DT.121316072  DT.40122678  DT.95365532  DT.121322821 
    DT.91731463  DT.95365534  DT.101971553  DT.75151231 

    24/148 AceView cDNA sequences (see all 148):

    AW150046 CA412816 BG565484 AA931510 AI206858 BG675717 CA841004 BM312466 
    BU189526 AI001760 AI217641 CA841265 AA669318 AF038392 CB243568 AK001426 
    BM710627 AA984455 AA036973 AI348642 NM_015891 BU736054 AI612888 BM682197 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDC40    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -                                                                           
    SP2:                                -                                                                           
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for CDC40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC40 expression in normal human tissues (normalized intensities)      CDC40 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTTGCTG
    CDC40 Expression
    About this image


    CDC40 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Brain (Nervous System)
             Choroid Plexus

    See CDC40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC40

    SOURCE GeneReport for Unigene cluster: Hs.428147
        SABiosciences Custom PCR Arrays for CDC40
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC40
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC40 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc401 , 5 cell division cycle 40 homolog (yeast)5
    cell division cycle 401
    91.82(n)1
    98.79(a)1
      10 (22.06 cM)5
    717131  NM_027879.21  NP_082155.11 
     408316265 
    chicken
    (Gallus gallus)
    Aves CDC401 cell division cycle 40 homolog (S. cerevisiae) 80.87(n)
    91.83(a)
      421760  NM_001006407.1  NP_001006407.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    70(a)
    1 ↔ many
    1 ↔ many
    5(150166555-150270371)
    1(191545086-191612701)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256952 Xenopus laevis transcribed sequence with moderate similarity more 80.75(n)    BU910336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc401 cell division cycle 40 homolog (S. cerevisiae) 71.11(n)
    82.84(a)
      494534  NM_001009990.1  NP_001009990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60151 CG6015 58.83(n)
    62.37(a)
      42593  NM_142748.4  NP_651005.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prp-171 Protein PRP-17 57.42(n)
    52.25(a)
      172999  NM_060450.3  NP_492851.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC40(YDR364C)4 Pre-mRNA splicing factor, important for catalytic step more   --   4(1204210-1202843) 851968  NP_010652.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G105801 pre-mRNA-processing factor 17 58.57(n)
    56.26(a)
      837599  NM_100933.2  NP_172528.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g03975001 hypothetical protein 53.22(n)
    52.67(a)
      4333045  NM_001056837.1  NP_001050302.1 


    ENSEMBL Gene Tree for CDC40 (if available)
    TreeFam Gene Tree for CDC40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC40 gene
    WDR252  
    3 SIMAP similar genes for CDC40 using alignment to 6 protein entries:     PRP17_HUMAN (see all proteins):
    POC1B    PF20    WDR5

    CDC40 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/892 SNPs in CDC40 are shown (see all 892)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744367301,2
    C,F--110503302(+) AAATCC/ATGCCT 1 -- int13Minor allele frequency- A:0.06WA NA EA 358
    rs598914101,2
    C,F--110503500(+) TTTATT/GTCCAG 1 -- int13Minor allele frequency- G:0.12WA CSA 122
    rs1820462351,2
    C--110503528(+) GCTTAC/TGATCT 1 -- int10--------
    rs77448281,2
    C,F,A,H--110503531(+) TACGAT/ACTTGA 1 -- int118Minor allele frequency- A:0.26NS EA NA WA CSA 1413
    rs762563331,2
    C,F--110503669(+) TTTGAT/GCTGTC 1 -- int13Minor allele frequency- G:0.04WA NA EA 358
    rs751538911,2
    C,F--110503714(+) CAAAGA/GAGGTA 1 -- int13Minor allele frequency- G:0.10WA NA EA 358
    rs560003411,2
    C--110503750(+) CCCCTA/GAAGCT 1 -- int10--------
    rs1866391061,2
    --110503787(+) TGTTTA/CATTAA 1 -- int10--------
    rs1463441321,2
    --110503821(+) TTGCTA/GTTTTC 1 -- int10--------
    rs1909997251,2
    --110503929(+) CAATGA/TTATTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CDC40 (110501344 - 110575478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDC40:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5439CNV Insertion18451855
    nsv886536CNV Loss21882294
    nsv886535CNV Loss21882294
    dgv2001e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDC40 for disorders           About MalaCards
    OMIM gene information: 605585    OMIM disorders: --


    CDC40 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDC40
    Human Genome Epidemiology (HuGE) Navigator: CDC40 (1 document)

    Export disorders for CDC40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC40 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CDC40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control. (PubMed id 9769104)1, 2, 3, 9 Ben-Yehuda S.... Kupiec M. (1998)
    2. Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. (PubMed id 9830021)1, 2, 3 Lindsey L.A. and Garcia-Blanco M.A. (1998)
    3. Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors. (PubMed id 19420964)1, 4 Miyaki M....Mori T. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    8. Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. (PubMed id 9524131)1, 2 Zhou Z. and Reed R. (1998)
    9. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PubMed id 9303539)1, 2 Salcini A.E....Di Fiore P.P. (1997)
    10. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51362 HGNC: 17350 AceView: CDC40 Ensembl:ENSG00000168438 euGenes: HUgn51362
    ECgene: CDC40 Kegg: 51362 H-InvDB: CDC40

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC40 gene:
    Search GeneIP for patents involving CDC40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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