CDC37L1 Gene
protein-coding GIFtS: 48
GCID: GC09P004671
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|
cell division cycle 37-like 1(Previous names: CDC37 cell division cycle 37 homolog (S. cerevisiae)-like...)
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Aliases
for CDC37L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cell Division Cycle 37-Like 11 2 | | CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 11 | | CDC37B1 2 3 | | Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 11 | | HARC1 2 3 | | CDC37 Cell Division Cycle 37 Homolog-Like 12 | | Hsp90-Associating Relative Of Cdc372 3 | | Cell Division Cycle 37 Homolog-Like 12 | | FLJ206391 | | Hsp90 Co-Chaperone Cdc37-Like 12 |
Export aliases for CDC37L1 gene to outside databasesPrevious GC identifer: GC09P004670 |
Summaries
for CDC37L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDC37L1:
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several otherproteins involved in HSP90-mediated protein folding (Scholz et al., 2001 (PubMed 11413142)).(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6Function: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (Bysimilarity)
|
Genomic Views
for CDC37L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC37L1 gene promoter:
Egr-3 AhR AML1a p53 CUTL1 Arnt AREB6 COMP1 FOXO1a STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC37L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC37L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.1 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.1CDC37L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P004671: view genomic region
(about GC identifiers)
Start:
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4,679,559 bp from pter |
End:
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4,708,398 bp from pter |
Size:
|
28,840 bases |
Orientation:
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plus strand |
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Proteins
for CDC37L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6 (See
protein sequence)Recommended Name: Hsp90 co-chaperone Cdc37-like 1 Size: 337 amino acids; 38835 Da
Subunit: Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAA91206.1; Type=Erroneous termination; Positions=124; Note=Translated as Cys;
Secondary accessions: B1AL70 Q9NWS3 Q9NX16Explore the universe of human proteins at neXtProt for CDC37L1: NX_Q7L3B6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L3B6
CDC37L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060383.2
ENSEMBL proteins: ENSP00000371282 ENSP00000371278
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CDC37L1 for ontologies About GeneDecksing
CDC37L1 Antibody Products:
Assay Products for CDC37L1: |
Protein
Domains /
Families
for CDC37L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDC37L1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L3B6ProtoNet protein and cluster: Q7L3B6 UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6Similarity: Belongs to the CDC37 family |
Function
for CDC37L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6Function: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37L1 |
3 GenomeRNAi human phenotypes for CDC37L1:
|
Pathways & Interactions
for CDC37L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC37L1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/7 Interacting proteins for CDC37L1 (Q7L3B63 ENSP000003712784) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051301 | cell division |
-- | -- |
CDC37L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDC37L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDC37L1
Search CenterWatch for drugs/clinical trials and news about CDC37L1 / CD37L
|
Transcripts
for CDC37L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDC37L1 gene: NM_017913.2 Unigene Cluster for CDC37L1: Cell division cycle 37 homolog (S. cerevisiae)-like 1 Hs.666439 [show with all ESTs]Unigene Representative Sequence: BM9130293 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381858 ENST00000381854(uc003zio.3) ENST00000479095
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDC37L1 (NM_017913) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC37L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC37L1 |
Additional cDNA sequence: AK000497.1 AK000646.1 AK225510.1 BC014133.2 5 DOTS entries: DT.95088784 DT.444218 DT.95288650 DT.97823512 DT.40106459 24/146 AceView cDNA sequences (see all 146): CD677225 BI827259 BM681851 CK904439 BX281115 CR615490 BM023456 BQ006919 D20489 AI378864 BG120409 BE465426 AA897202 BQ574391 BE502581 AW631460 CR598577 AI026153 BC014133 Z38766 CD107699 CB155972 BM723544 AW196248
GeneLoc Exon Structure
|
Expression
for CDC37L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC37L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTATTCTA
About this image
See CDC37L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC37L1
SOURCE GeneReport for Unigene cluster: Hs.666439
UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6Tissue specificity: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle
SABiosciences Custom PCR Arrays for CDC37L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC37L1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37L1 |
Orthologs
for CDC37L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDC37L1 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDC37L11 |
cell division cycle 37 homolog (S. cerevisiae)-like more |
77.18(n)
74.19(a) |
|
426535 XM_424174.3 XP_424174.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CDC37L16 |
-- |
63(a) |
1 ↔ 1 |
2(52082415-52095220) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.42722 |
Transcribed sequence with weak similarity to protein more |
79.23(n) |
|
AL901188.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.176992 |
Transcribed sequence with weak similarity to protein more |
70.98(n) |
|
57095461 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cdc376 |
Cdc37 |
21(a) |
1 → many |
3L(1795392-1797307) |
worm
(Caenorhabditis elegans) |
Secernentea |
cdc-376 |
Probable Hsp90 co-chaperone cdc37 |
17(a) |
1 → many |
II(577530-580592) |
ENSEMBL Gene Tree for CDC37L1 (if available)
TreeFam Gene Tree for CDC37L1 (if available) |
Paralogs
for CDC37L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDC37L1 gene
- CDC372
1 SIMAP similar gene for CDC37L1 using alignment to 2 protein entries: CD37L_HUMAN (see all proteins):CDC37
CDC37L1 for paralogs About GeneDecksing
|
Genomic Variants
for CDC37L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDC37L1 (4679559 - 4708398 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CDC37L1
1 CNV: 59534
1 Indel: 59533 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC37L1 |
|
Disorders
/ Diseases
for CDC37L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDC37L1 for disorders About GeneDecksing
OMIM gene information: 610346
OMIM disorders: --
1  disease for CDC37L1: About MalaCardsprimary hyperoxaluria
1 disease from the University of Copenhagen DISEASES database for CDC37L1:Primary hyperoxaluria Export disorders for CDC37L1 gene to outside databases
|
Publications
for CDC37L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDC37L1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CDC37L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. (PubMed id 15850399)1, 2, 9 Roiniotis J.... Scholz G.M. (2005)
- Identification and characterization of Harc, a novel Hsp90- associating relative of Cdc37. (PubMed id 11413142)1, 2, 9 Scholz G.M.... Hall N.E. (2001)
- Importance of the C-terminal domain of harc for binding to hsp70 and hop as well as its response to heat shock. (PubMed id 18052042)1, 2 Cartledge K.... Scholz G.M. (2007)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Scanning the human proteome for calmodulin-binding pr oteins. (PubMed id 15840729)1 Shen X....Liu R. (2005)
|
External Searches for CDC37L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDC37L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDC37L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDC37L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDC37L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDC37L1 gene:
Search GeneIP for patents involving CDC37L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC37L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CDC37L1 | | OriGene shRNA RFP for CDC37L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC37L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC37L1 | | | OriGene Protein Over-expression Lysate for CDC37L1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDC37L1 | | OriGene 3'-UTR Clone for CDC37L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CDC37L1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDC37L1 | | OriGene Custom Protein Services for CDC37L1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC37L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC37L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC37L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC37L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC37L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC37L1 |
| |
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