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Aliases for CDC37L1 Gene

Aliases for CDC37L1 Gene

  • Cell Division Cycle 37 Like 1 2 3
  • Cell Division Cycle 37-Like 1 2 3 5
  • Hsp90-Associating Relative Of Cdc37 3 4
  • CDC37B 3 4
  • HARC 3 4
  • CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 1 2
  • Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 1 2
  • CDC37 Cell Division Cycle 37 Homolog-Like 1 3
  • Cell Division Cycle 37 Homolog-Like 1 3

External Ids for CDC37L1 Gene

Previous GeneCards Identifiers for CDC37L1 Gene

  • GC09P004670

Summaries for CDC37L1 Gene

Entrez Gene Summary for CDC37L1 Gene

  • CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CDC37L1 Gene

CDC37L1 (Cell Division Cycle 37 Like 1) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is CDC37.

UniProtKB/Swiss-Prot for CDC37L1 Gene

  • Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC37L1 Gene

Genomics for CDC37L1 Gene

Regulatory Elements for CDC37L1 Gene

Promoters for CDC37L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC37L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC37L1 Gene

Chromosome:
9
Start:
4,679,553 bp from pter
End:
4,708,399 bp from pter
Size:
28,847 bases
Orientation:
Plus strand

Genomic View for CDC37L1 Gene

Genes around CDC37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC37L1 Gene

Proteins for CDC37L1 Gene

  • Protein details for CDC37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3B6-CD37L_HUMAN
    Recommended name:
    Hsp90 co-chaperone Cdc37-like 1
    Protein Accession:
    Q7L3B6
    Secondary Accessions:
    • B1AL70
    • Q9NWS3
    • Q9NX16

    Protein attributes for CDC37L1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38835 Da
    Quaternary structure:
    • Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1.
    SequenceCaution:
    • Sequence=BAA91206.1; Type=Erroneous termination; Positions=124; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for CDC37L1 Gene

Proteomics data for CDC37L1 Gene at MOPED

Post-translational modifications for CDC37L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC37L1 Gene

Domains & Families for CDC37L1 Gene

Protein Domains for CDC37L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC37L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L3B6

UniProtKB/Swiss-Prot:

CD37L_HUMAN :
  • Belongs to the CDC37 family.
Family:
  • Belongs to the CDC37 family.
genes like me logo Genes that share domains with CDC37L1: view

No data available for Gene Families for CDC37L1 Gene

Function for CDC37L1 Gene

Molecular function for CDC37L1 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.

Gene Ontology (GO) - Molecular Function for CDC37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with CDC37L1: view
genes like me logo Genes that share phenotypes with CDC37L1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC37L1 Gene

Localization for CDC37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC37L1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC37L1 Gene COMPARTMENTS Subcellular localization image for CDC37L1 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CDC37L1 Gene

Pathways & Interactions for CDC37L1 Gene

genes like me logo Genes that share pathways with CDC37L1: view

Gene Ontology (GO) - Biological Process for CDC37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050821 protein stabilization IBA --
genes like me logo Genes that share ontologies with CDC37L1: view

No data available for SIGNOR curated interactions for CDC37L1 Gene

Drugs & Compounds for CDC37L1 Gene

No Compound Related Data Available

Transcripts for CDC37L1 Gene

mRNA/cDNA for CDC37L1 Gene

Unigene Clusters for CDC37L1 Gene

Cell division cycle 37-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC37L1 Gene

No ASD Table

Relevant External Links for CDC37L1 Gene

GeneLoc Exon Structure for
CDC37L1
ECgene alternative splicing isoforms for
CDC37L1

Expression for CDC37L1 Gene

mRNA expression in normal human tissues for CDC37L1 Gene

mRNA differential expression in normal tissues according to GTEx for CDC37L1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.0).

Protein differential expression in normal tissues from HIPED for CDC37L1 Gene

This gene is overexpressed in Bone (32.3), Plasma (13.1), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC37L1 Gene



SOURCE GeneReport for Unigene cluster for CDC37L1 Gene Hs.666439

mRNA Expression by UniProt/SwissProt for CDC37L1 Gene

Q7L3B6-CD37L_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with CDC37L1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CDC37L1 Gene

Orthologs for CDC37L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDC37L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC37L1 35
  • 99.8 (n)
  • 99.41 (a)
CDC37L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC37L1 36
  • 95 (a)
OneToOne
CDC37L1 35
  • 94.08 (n)
  • 94.41 (a)
dog
(Canis familiaris)
Mammalia CDC37L1 35
  • 94.36 (n)
  • 95.55 (a)
CDC37L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc37l1 16
Cdc37l1 35
  • 88.96 (n)
  • 89.25 (a)
Cdc37l1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC37L1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC37L1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc37l1 35
  • 88.46 (n)
  • 87.76 (a)
chicken
(Gallus gallus)
Aves CDC37L1 35
  • 77.69 (n)
  • 75.88 (a)
CDC37L1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC37L1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc37l1 35
  • 70.88 (n)
  • 61.05 (a)
Str.4272 35
zebrafish
(Danio rerio)
Actinopterygii cdc37l1 36
  • 41 (a)
OneToOne
cdc37l1 35
  • 58.88 (n)
  • 54.92 (a)
Dr.17699 35
fruit fly
(Drosophila melanogaster)
Insecta Cdc37 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-37 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for CDC37L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC37L1 Gene

ENSEMBL:
Gene Tree for CDC37L1 (if available)
TreeFam:
Gene Tree for CDC37L1 (if available)

Paralogs for CDC37L1 Gene

Paralogs for CDC37L1 Gene

(1) SIMAP similar genes for CDC37L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDC37L1: view

Variants for CDC37L1 Gene

Sequence variations from dbSNP and Humsavar for CDC37L1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7036014 - 4,701,988(+) CCATT(C/T)TGGTG reference, missense
rs378549 -- 4,702,830(-) ctcac(C/T)gcaag intron-variant
rs453852 -- 4,695,291(-) GAGAG(C/G)ACACC intron-variant
rs296820 -- 4,707,896(-) GAAAT(C/T)CAAAA utr-variant-3-prime
rs296821 -- 4,708,825(+) GGAGG(C/G)TGAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CDC37L1 Gene

Variant ID Type Subtype PubMed ID
nsv892125 CNV Gain 21882294
nsv892126 CNV Gain 21882294
nsv892127 CNV Gain 21882294
nsv819702 CNV Gain 19587683
nsv819262 CNV Loss 19587683

Variation tolerance for CDC37L1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC37L1 Gene

HapMap Linkage Disequilibrium report
CDC37L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC37L1 Gene

Disorders for CDC37L1 Gene

Relevant External Links for CDC37L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC37L1

No disorders were found for CDC37L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC37L1 Gene

Publications for CDC37L1 Gene

  1. Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. (PMID: 15850399) Roiniotis J. … Scholz G.M. (Biochemistry 2005) 3 4 23 67
  2. Identification and characterization of Harc, a novel Hsp90- associating relative of Cdc37. (PMID: 11413142) Scholz G.M. … Hall N.E. (J. Biol. Chem. 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CDC37L1 Gene

Sources for CDC37L1 Gene

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