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CDC37L1 Gene

protein-coding   GIFtS: 46
GCID: GC09P004671

Cell Division Cycle 37-Like 1

(Previous names: CDC37 cell division cycle 37 homolog (S. cerevisiae)-like...)
  Search for CDC37L1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 37-Like 11 2     Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 11
HARC2 3 5     CDC37 Cell Division Cycle 37 Homolog-Like 12
CDC37B2 3     Cell Division Cycle 37 Homolog-Like 12
Hsp90-Associating Relative Of Cdc372 3     Hsp90 Co-Chaperone Cdc37-Like 12
CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)-Like 11     FLJ206395

External Ids:    HGNC: 171791   Entrez Gene: 556642   Ensembl: ENSG000001069937   OMIM: 6103465   UniProtKB: Q7L3B63   

Export aliases for CDC37L1 gene to outside databases

Previous GC identifer: GC09P004670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC37L1 Gene:
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several
other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 (PubMed 11413142)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for CDC37L1 Gene:
CDC37L1 (cell division cycle 37-like 1) is a protein-coding gene. An important paralog of this gene is CDC37.

UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6
Function: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDC37L1 gene promoter:
         Egr-3   AhR   AML1a   p53   CUTL1   Arnt   AREB6   COMP1   FOXO1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC37L1 promoter sequence
   Search Chromatin IP Primers for CDC37L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC37L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

CDC37L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC37L1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P004671:  view genomic region     (about GC identifiers)

Start:
4,679,559 bp from pter      End:
4,708,398 bp from pter
Size:
28,840 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6 (See protein sequence)
Recommended Name: Hsp90 co-chaperone Cdc37-like 1  
Size: 337 amino acids; 38835 Da
Subunit: Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1
Sequence caution: Sequence=BAA91206.1; Type=Erroneous termination; Positions=124; Note=Translated as Cys;
Secondary accessions: B1AL70 Q9NWS3 Q9NX16

Explore the universe of human proteins at neXtProt for CDC37L1: NX_Q7L3B6

Explore proteomics data for CDC37L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC37L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060383.2  
    ENSEMBL proteins: 
     ENSP00000371282   ENSP00000371278  

    CDC37L1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDC37L1

     
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    Search eBioscience for ELISAs for CDC37L1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004918 Cdc37
     IPR013874 Cdc37_Hsp90-bd

    Graphical View of Domain Structure for InterPro Entry Q7L3B6

    ProtoNet protein and cluster: Q7L3B6

    UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6
    Similarity: Belongs to the CDC37 family


    Find genes that share domains with CDC37L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD37L_HUMAN, Q7L3B6
    Function: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (By
    similarity)

    Phenotypes:
         3 GenomeRNAi human phenotypes for CDC37L1:

     Decreased POU5F1-GFP protein e  Decreased viability with cispl  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC37L1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC37L1

    miRNA
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    miRTarBase miRNAs that target CDC37L1:
    hsa-mir-484 (MIRT042137), hsa-mir-103a-3p (MIRT027214), hsa-mir-93-5p (MIRT028177), hsa-mir-16-5p (MIRT032005), hsa-mir-130b-5p (MIRT038307), hsa-mir-106b-5p (MIRT020478)

    Block miRNA regulation of human, mouse, rat CDC37L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC37L1 (see all 31):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-137 hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCDC37L1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD37L_HUMAN, Q7L3B6: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CDC37L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC37L1
    Interactions:

        GeneGlobe Interaction Network for CDC37L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC37L1 (Q7L3B63 ENSP000003712784) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC37L1 (CD37L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC37L1 gene: 
    NM_017913.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381858 ENST00000381854(uc003zio.3) ENST00000479095
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDC37L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC37L1 (see all 31):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-137 hsa-miR-15a hsa-miR-106a hsa-miR-503 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCDC37L1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDC37L1
    Predesigned siRNA for gene silencing in human, mouse, rat CDC37L1
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    Primer
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    OriGene qPCR primer pairs and template standards for CDC37L1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC37L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC37L1
      QuantiTect SYBR Green Assays in human, mouse, rat CDC37L1
      QuantiFast Probe-based Assays in human, mouse, rat CDC37L1

    Selected AceView cDNA sequences (see all 146):

    BM023456 AI142860 BM023174 BX281115 CK904439 AI200705 AL536837 BE502581 
    BM021406 AW151600 AA889382 BM681851 BM723544 CR598577 BE465426 CD107699 
    BC014133 AA975123 H96990 BQ006919 AW631460 BG120409 AW627679 CK904438 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC37L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTATTCTA
    CDC37L1 Expression
    About this image

    CDC37L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC37L1 Protein Expression

    UniProtKB/Swiss-Prot: CD37L_HUMAN, Q7L3B6
    Tissue specificity: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle

        Custom PCR Arrays for CDC37L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDC37L1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc37l11 , 5 cell division cycle 37 homolog (S. cerevisiae)-like more5
    cell division cycle 37-like 11
    88.96(n)1
    89.25(a)1
      19 (23.61 cM)5
    670721  NM_025950.21  NP_080226.11 
     289904945 
    chicken
    (Gallus gallus)
    Aves CDC37L11 cell division cycle 37 homolog (S. cerevisiae)-like more 77.69(n)
    75.88(a)
      426535  XM_424174.4  XP_424174.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDC37L16
    cell division cycle 37-like 1
    71(a)
    1 ↔ 1
    2(52081687-52095268)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.42722 Transcribed sequence with weak similarity to protein more 79.23(n)    AL901188.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.176992 Transcribed sequence with weak similarity to protein more 70.98(n)    57095461 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdc376
    Cdc37
    22(a)
    1 → many
    3L(1795392-1797307)
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-376
    Protein CDC-37, isoform b (cdc-37) mRNA, complete ...
    17(a)
    1 → many
    II(577531-580593) WBGene00021097


    ENSEMBL Gene Tree for CDC37L1 (if available)
    TreeFam Gene Tree for CDC37L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC37L1 gene
    CDC372  
    1 SIMAP similar gene for CDC37L1 using alignment to 2 protein entries:     CD37L_HUMAN (see all proteins):
    CDC37

    Find genes that share paralogs with CDC37L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC37L1 (see all 690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842720261,2
    --4677595(+) TTGATC/TGACAC 1 -- int10--------
    rs107586411,2
    C,F,A,H--4677630(+) GAAGGG/CGGTGA 1 -- int112Minor allele frequency- C:0.46NA WA CSA EA 374
    rs107586421,2
    C,F,A,H--4677647(+) GGGTTC/TGGATG 1 -- int127Minor allele frequency- T:0.47NS EA NA WA CSA 2770
    rs109747251,2
    C,F,H--4677703(+) TCAGCG/AGGTAG 1 -- int15Minor allele frequency- A:0.02NS EA WA 536
    rs1878597721,2
    --4677742(+) CAGGAC/GTTGGA 1 -- int10--------
    rs1425314541,2
    --4677793(+) GCCACA/TGGAAT 1 -- int10--------
    rs1924730121,2
    --4677853(+) GGTCAC/GCTAGA 1 -- int10--------
    rs1845599761,2
    --4677903(+) GAAAAA/GCTAAC 1 -- int10--------
    rs1894768111,2
    --4678020(+) CCAGTC/GTCTCC 1 -- int10--------
    rs1807733551,2
    C--4678078(+) CTCAGC/TTTTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CDC37L1 (4679559 - 4708398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDC37L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819262CNV Loss19587683
    nsv892126CNV Gain21882294
    nsv819702CNV Gain19587683
    nsv892125CNV Gain21882294
    nsv892127CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC37L1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC37L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610346    OMIM disorders: --


    Find genes that share disorders with CDC37L1           About GenesLikeMe


    Export disorders for CDC37L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC37L1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CDC37L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. (PubMed id 15850399)1, 2, 9 Roiniotis J.... Scholz G.M. (Biochemistry 2005)
    2. Identification and characterization of Harc, a novel Hsp90- associating relative of Cdc37. (PubMed id 11413142)1, 2, 9 Scholz G.M.... Hall N.E. (J. Biol. Chem. 2001)
    3. Importance of the C-terminal domain of harc for binding to hsp70 and hop as well as its response to heat shock. (PubMed id 18052042)1, 2 Cartledge K.... Scholz G.M. (Biochemistry 2007)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55664 HGNC: 17179 AceView: CDC37L1 Ensembl:ENSG00000106993 euGenes: HUgn55664
    ECgene: CDC37L1 H-InvDB: CDC37L1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC37L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC37L1 gene:
    Search GeneIP for patents involving CDC37L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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