Aliases for CDC37 Gene
External Ids for CDC37 Gene
Previous GeneCards Identifiers for CDC37 Gene
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC37 Gene
CDC37 (Cell Division Cycle 37) is a Protein Coding gene. Among its related pathways are Aryl Hydrocarbon Receptor and Signaling by Ligand-Responsive EGFR Variants in Cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CDC37L1.
UniProtKB/Swiss-Prot for CDC37 Gene
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).