CDC37 Gene
protein-coding GIFtS: 64
GCID: GC19M010501
|
|
cell division cycle 37(Previous names: CDC37 (cell division cycle 37, S. cerevisiae, homolog),...)
| |
Aliases
for CDC37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cell Division Cycle 371 2 | | CDC37 Cell Division Cycle 37 Homolog2 | | P50CDC371 2 | | Cell Division Cycle 37 Homolog2 | | CDC37 (Cell Division Cycle 37, S. Cerevisiae, Homolog)1 2 | | Hsp90 Co-Chaperone Cdc372 | | Hsp90 Chaperone Protein Kinase-Targeting Subunit2 3 | | CDC37A3 | | CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)1 | | P50Cdc371 | | Cell Division Cycle 37 Homolog (S. Cerevisiae)1 | | |
Export aliases for CDC37 gene to outside databasesPrevious GC identifers: GC19M010623 GC19M010724 GC19M010348 GC19M010362 GC19M010081 |
Summaries
for CDC37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDC37:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromycescerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has beenshown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well aseIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resultingin stabilization and promotion of their activity
Gene Wiki entry for CDC37
|
Genomic Views
for CDC37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC37 gene promoter:
Pbx1a XBP-1 Nkx2-5 LCR-F1 C/EBPalpha AREB6 CREB deltaCREB STAT3 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2CDC37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M010501: view genomic region
(about GC identifiers)
Start:
|
10,501,809 bp from pter |
End:
|
10,530,797 bp from pter |
Size:
|
28,989 bases |
Orientation:
|
minus strand |
|
Proteins
for CDC37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543 (See
protein sequence)Recommended Name: Hsp90 co-chaperone Cdc37 Size: 378 amino acids; 44468 Da
Subunit: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1
Subcellular location: Cytoplasm
3 PDB 3D structures from  and Proteopedia  for CDC37:1US7 (3D)
2K5B (3D)
2W0G (3D)
Secondary accessions: Q53YA2Explore the universe of human proteins at neXtProt for CDC37: NX_Q16543
Post-translational modifications:
Constitutively sumoylated by UBE2I1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16543
CDC37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008996.1
ENSEMBL proteins: ENSP00000222005 ENSP00000465941 ENSP00000464889 ENSP00000467747 ENSP00000465724 ENSP00000464971 Reactome Protein details: Q16543
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CDC37 for ontologies About GeneDecksing
CDC37 Antibody Products:
Assay Products for CDC37: |
Protein
Domains /
Families
for CDC37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDC37 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16543ProtoNet protein and cluster: Q16543 1 Blocks protein family: IPB004918 Cdc37 family
UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543Similarity: Belongs to the CDC37 family |
Function
for CDC37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resultingin stabilization and promotion of their activity Genatlas biochemistry entry for CDC37:cell division cycle 37,S cerevisiae homolog,protein kinase targetting subunit of HSP90 that binds and stabilizes CDK4(HSPC*),potential regulator of cell cycle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDC37 (NM_007065) | |  | Sino Biological Human cDNA Clone for CDC37 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC37 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC37 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CDC37 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CDC37:
|
Pathways & Interactions
for CDC37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | Protein Stability | | | 3 | Cytoskeletal Signaling | | | 4 | Cell Cycle / Checkpoint Control | | | 5 | Disease | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDC37
3 
Cell Signaling Technology (CST) Pathways for CDC37
2  BioSystems Pathways for CDC37
5 
Reactome Pathways for CDC37
CDC37 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC37
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/171 Interacting proteins for CDC37 (Q165431, 2, 3 ENSP000002220054) via UniProtKB, MINT, STRING, and/or I2D (see all 171)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MAP3K7 | O433182, 3, ENSP000003583354 | MINT-6797194 MINT-6797182 MINT-48030 MINT-49225 MINT-6797216 MINT-6797232 I2D:
score=1 STRING: ENSP00000358335 | | MAP3K3 | Q997592, 3, ENSP000003549274 | MINT-47991 MINT-48407 I2D:
score=4 STRING: ENSP00000354927 | | TBK1 | Q9UHD22, 3, ENSP000003299674 | MINT-48037 MINT-49260 I2D:
score=4 STRING: ENSP00000329967 | | CHUK | O151112, 3, ENSP000003594244 | MINT-47951 I2D:
score=4 STRING: ENSP00000359424 | | SQSTM1 | Q135012, 3, ENSP000003744554 | MINT-8251010 I2D:
score=4 STRING: ENSP00000374455 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CDC37 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDC37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDC37 for compounds About GeneDecksing
 Browse Tocris compounds for CDC37
1 HMDB Compound for CDC37 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
10 Novoseek chemical compound relationships for CDC37 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| geldanamycin |
86.4 |
10 |
15922741 (2), 11036079 (2), 17223712 (1), 15935620 (1) (see all 6) |
| 17-(allylamino)-17-demethoxygeldanamycin |
85.3 |
2 |
18089825 (1) |
| alpha e |
74.4 |
1 |
16285732 (1) |
| molybdate |
66 |
5 |
15258137 (2), 16285732 (1), 14580201 (1) |
| novobiocin |
57.2 |
3 |
15209518 (2) |
| threonine |
36.3 |
1 |
16611982 (1) |
| serine |
26.4 |
2 |
18566753 (1), 15082798 (1) |
| atp |
15 |
4 |
19858214 (1), 14701845 (1), 17922836 (1) |
| phosphatidylinositol |
2.77 |
1 |
12176997 (1) |
| tyrosine |
0 |
3 |
16285732 (1), 15258137 (1), 14580201 (1) |
Search CenterWatch for drugs/clinical trials and news about CDC37
|
Transcripts
for CDC37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDC37 gene: NM_007065.3 Unigene Cluster for CDC37: Cell division cycle 37 homolog (S. cerevisiae) Hs.160958 [show with all ESTs]Unigene Representative Sequence: NM_00706510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000222005(uc002mof.1) ENST00000591248 ENST00000589625 ENST00000589331
ENST00000590632 ENST00000589629 ENST00000593124 ENST00000589755 ENST00000588498
ENST00000588869
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDC37 (NM_007065) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDC37 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC37 |
Additional cDNA sequence: BC000083.2 BC008793.2 BC127212.1 BC127213.1 BC141928.1 BC141929.1 BT006796.1 CR542249.1 U43077.1 U63131.1 20 DOTS entries: DT.100674958 DT.455787 DT.100846570 DT.100762554 DT.100674949 DT.100874359 DT.100674966 DT.455786 DT.99977587 DT.95084816 DT.100674964 DT.121480552 DT.100674943 DT.95324945 DT.100674965 DT.121480503 DT.100644635 DT.100767423 DT.92049452 DT.95363406 24/760 AceView cDNA sequences (see all 760): BE698645 BM423839 BM919959 BQ058092 CR623653 BQ028487 AW160463 BQ951821 BG387528 CA421856 BM810150 CB118320 CR591546 AI367487 BC008793 BU192734 AI784682 CR599394 CR625450 BQ278617 BQ719687 BC000083 BI832529 CR623169
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CDC37 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|
|
| SP1: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDC37
|
Expression
for CDC37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCGCTGCA
About this image
See CDC37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC37
SOURCE GeneReport for Unigene cluster: Hs.160958
SABiosciences Custom PCR Arrays for CDC37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDC37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37 |
Orthologs
for CDC37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for CDC37 gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cdc371 , 5 |
cell division cycle 37 homolog (S. cerevisiae)5
cell division cycle 371 |
88.33(n)1
95.49(a)1 |
|
9 (7.72 cM)5
125391 NM_016742.41 NP_058022.11
211385415 |
lizard
(Anolis carolinensis) |
Reptilia |
CDC376 |
-- |
80(a) |
1 ↔ 1 |
2(27907321-27925447) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cdc37-prov2 |
CDC37 cell division cycle 37 homolog (S. cerevisiae) |
78.88(n) |
|
BC041715.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc562102 |
similar to cell division cycle 37 homolog (S. cerevisiae) |
81.48(n) |
|
394013 BC045994.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cdc371 , 3 |
protein kinase cascade co-chaperone3
CG12019-PA1 |
52(a)3
62.24(n)1
52.57(a)1 |
|
3 62B43
382321 NM_057658.41 NP_477006.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
W08F4.83
cdc-371 |
Protein CDC-371 |
38(a)3
53.95(n)1
41.24(a)1 |
|
II(578085-579883)3
1734491 NM_001047356.31 NP_001040821.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CDC371 |
Cdc37p |
42.52(n)
25.64(a) |
|
851746 NP_010452.1 |
ENSEMBL Gene Tree for CDC37 (if available)
TreeFam Gene Tree for CDC37 (if available) |
Paralogs
for CDC37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDC37 gene
- CDC37L12
2 SIMAP similar genes for CDC37 using alignment to 7 protein entries: CDC37_HUMAN (see all proteins):MBD5 CDC37L1
CDC37 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CDC37
PGOHUM00000259034 PGOHUM00000259108 PGOHUM00000235440
|
Genomic Variants
for CDC37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDC37 (10501809 - 10530797 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDC37
1 CNV: 67465 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC37 |
|
Disorders
/ Diseases
for CDC37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDC37 for disorders About GeneDecksing
OMIM gene information: 605065
OMIM disorders: --
13  diseases for CDC37: About MalaCardspeutz-jeghers syndrome multiple myeloma chondrosarcoma prostate cancer
acute leukemia myeloma liver cancer pancreatic cancer
prostatitis pancreatitis leukemia melanoma
carcinoma
5 Novoseek disease relationships for CDC37 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
57.2 |
13 |
12727831 (1), 20226165 (1), 17728246 (1), 19703551 (1) (see all 11) |
| cancer |
19.4 |
18 |
18931700 (3), 19177013 (3), 19387550 (1), 15661534 (1) (see all 6) |
| tumors |
3.34 |
7 |
19387550 (1), 10822368 (1), 18089825 (1), 18922470 (1) |
| prostate cancer |
0 |
5 |
10822368 (2), 18089825 (1), 12907640 (1) |
| hyperplasia |
0 |
1 |
12907640 (1) |
Human Genome Epidemiology (HuGE) Navigator: CDC37 (1 document)
Export disorders for CDC37 gene to outside databases
|
Publications
for CDC37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDC37 gene, integrated from 9 sources (see all 155):
(articles sorted by number of sources associating them with CDC37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (PubMed id 8666233)1, 2, 3 Stepanova L.... Harper J.W. (1996)
- Physical interaction of mammalian CDC37 with CDK4. (PubMed id 8703009)1, 2, 3 Dai K.... Beach D. (1996)
- Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase. (PubMed id 11036079)1, 2, 9 Shao J.... Matts R.L. (2001)
- Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. (PubMed id 11085988)1, 2, 9 Rao J....Caplan A.J. (2001)
- Interaction between Cdc37 and Cdk4 in human cells. (PubMed id 9150368)1, 2, 9 Lamphere L.... Gyuris J. (1997)
- Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (2007)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. (PubMed id 10858314)1, 2 Hartson S.D....Matts R.L. (2000)
- CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. (PubMed id 15082798)1, 9 Miyata Y. and Nishida E. (2004)
|
External Searches for CDC37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDC37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDC37 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDC37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDC37 gene:
Search GeneIP for patents involving CDC37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CDC37 | | OriGene shRNA RFP for CDC37 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC37 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC37 | | | OriGene Protein Over-expression Lysate for CDC37 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDC37 | | OriGene 3'-UTR Clone for CDC37 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC37 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CDC37 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDC37 | | OriGene Custom Protein Services for CDC37 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC37 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC37 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC37 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC37 |
| |
 |  |  |  | |
| | Antibodies & Assays for CDC37 |
| | | | Search Tocris compounds for CDC37 |
| |  |  |  |  | | | | | | Recombinant Protein for CDC37 |
|
 |
 |
 |
 | | | CDC37 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37 |
|  |  |  | | | | ThermoFisher Antibody for CDC37 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC37 |
|
|
|
|
