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CDC37 Gene

protein-coding   GIFtS: 66
GCID: GC19M010501

Cell Division Cycle 37

(Previous names: CDC37 (cell division cycle 37, S. cerevisiae, homolog),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 371 2     Cell Division Cycle 37 Homolog (S. Cerevisiae)1
CDC37 (Cell Division Cycle 37, S. Cerevisiae, Homolog)1 2     homolog)1
CDC37 Cell Division Cycle 37 Homolog1 2     S. Cerevisiae1
Hsp90 Co-Chaperone Cdc371 2     P50CDC372
Hsp90 Chaperone Protein Kinase-Targeting Subunit2 3     Cell Division Cycle 37 Homolog2
CDC37 (Cell Division Cycle 371     CDC37A3
CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae)1     p50Cdc373

External Ids:    HGNC: 17351   Entrez Gene: 111402   Ensembl: ENSG000001054017   OMIM: 6050655   UniProtKB: Q165433   

Export aliases for CDC37 gene to outside databases

Previous GC identifers: GC19M010623 GC19M010724 GC19M010348 GC19M010362 GC19M010081


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC37 Gene:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of
Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal
transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6,
SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its
target kinases. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC37 Gene:
CDC37 (cell division cycle 37) is a protein-coding gene. Diseases associated with CDC37 include peutz-jeghers syndrome, and chondrosarcoma. GO annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is CDC37L1.

UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543
Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex,
resulting in stabilization and promotion of their activity

Gene Wiki entry for CDC37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC37 gene promoter:
         Pbx1a   XBP-1   Nkx2-5   LCR-F1   C/EBPalpha   AREB6   CREB   deltaCREB   STAT3   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC37 promoter sequence
   Search Chromatin IP Primers for CDC37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CDC37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC37 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010501:  view genomic region     (about GC identifiers)

Start:
10,501,809 bp from pter      End:
10,530,797 bp from pter
Size:
28,989 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543 (See protein sequence)
Recommended Name: Hsp90 co-chaperone Cdc37  
Size: 378 amino acids; 44468 Da
Subunit: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1
3 PDB 3D structures from and Proteopedia for CDC37:
1US7 (3D)        2K5B (3D)        2W0G (3D)    
Secondary accessions: Q53YA2

Explore the universe of human proteins at neXtProt for CDC37: NX_Q16543

Explore proteomics data for CDC37 at MOPED

Post-translational modifications: 

  • Constitutively sumoylated by UBE2I1
  • Ubiquitination2 at Lys110, Lys121, Lys330
  • Modification sites at PhosphoSitePlus

  • See CDC37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008996.1  
    ENSEMBL proteins: 
     ENSP00000222005   ENSP00000465941   ENSP00000464889   ENSP00000467747   ENSP00000465724  
     ENSP00000464971  
    Reactome Protein details: Q16543

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013873 Cdc37_C
     IPR004918 Cdc37
     IPR013874 Cdc37_Hsp90-bd
     IPR013855 Cdc37_N_dom

    Graphical View of Domain Structure for InterPro Entry Q16543

    ProtoNet protein and cluster: Q16543

    1 Blocks protein domain: IPB004918 Cdc37 family

    UniProtKB/Swiss-Prot: CDC37_HUMAN, Q16543
    Similarity: Belongs to the CDC37 family


    CDC37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC37_HUMAN, Q16543
    Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex,
    resulting in stabilization and promotion of their activity

         Genatlas biochemistry entry for CDC37:
    cell division cycle 37,S cerevisiae homolog,protein kinase targetting subunit of HSP90 that binds and stabilizes
    CDK4 (HSPC*),potential regulator of cell cycle

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11036079
    GO:0019901protein kinase binding ----
    GO:0031072heat shock protein binding IPI9660753
    GO:0031435mitogen-activated protein kinase kinase kinase binding IEA--
    GO:0043422protein kinase B binding IEA--
         
    CDC37 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC37:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CDC37:
    hsa-mir-3200-3p (MIRT052815), hsa-mir-615-3p (MIRT016144), hsa-mir-92a-3p (MIRT049255), hsa-mir-193b-3p (MIRT016565), hsa-mir-16-5p (MIRT031991), hsa-mir-7-5p (MIRT025907), hsa-mir-421 (MIRT039401)

    Block miRNA regulation of human, mouse, rat CDC37 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CDC37:
    hsa-miR-34b* hsa-miR-1271 hsa-miR-888 hsa-miR-182 hsa-miR-330-3p hsa-miR-96 hsa-miR-449c hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDC37 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC37_HUMAN, Q16543: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0032587ruffle membrane IEA--
    GO:0043234protein complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    CDC37 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC37 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR in Cancer0.82
    2Akt Signaling
    Akt Signaling0.60
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDC37
        Akt Signaling

    3 Cell Signaling Technology (CST) Pathways for CDC37
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling
    Protein Stability

    3 BioSystems Pathways for CDC37
        TNF-alpha/NF-kB Signaling Pathway
    AhR pathway
    LKB1 signaling events


    2 Reactome Pathways for CDC37
        Signaling by ERBB2
    Signaling by constitutively active EGFR


    1 Kegg Pathway  (Kegg details for CDC37):
        PI3K-Akt signaling pathway


    CDC37 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC37
    Interactions:

        GeneGlobe Interaction Network for CDC37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC37 (Q165431, 2, 3 ENSP000002220054) via UniProtKB, MINT, STRING, and/or I2D (see all 236)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151111, 2, 3, ENSP000003594244EBI-295634,EBI-81249 MINT-47951 I2D: score=4 STRING: ENSP00000359424
    SQSTM1Q135011, 2, 3, ENSP000003744554EBI-295634,EBI-307104 MINT-8251010 I2D: score=4 STRING: ENSP00000374455
    MAP3K7O433182, 3, ENSP000003583354MINT-6797194 MINT-6797182 MINT-48030 MINT-49225 MINT-6797216 MINT-6797232 I2D: score=1 STRING: ENSP00000358335
    MAP3K3Q997592, 3, ENSP000003549274MINT-47991 MINT-48407 I2D: score=4 STRING: ENSP00000354927
    TBK1Q9UHD22, 3, ENSP000003299674MINT-48037 MINT-49260 I2D: score=4 STRING: ENSP00000329967
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8666233
    GO:0006605protein targeting TAS8666233
    GO:0051726regulation of cell cycle ----
    GO:0060334regulation of interferon-gamma-mediated signaling pathway IMP16280321
    GO:0060338regulation of type I interferon-mediated signaling pathway IMP16280321

    CDC37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC37

    1 HMDB Compound for CDC37    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    10 Novoseek inferred chemical compound relationships for CDC37 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 86.4 10 15922741 (2), 11036079 (2), 17223712 (1), 15935620 (1) (see all 6)
    17-(allylamino)-17-demethoxygeldanamycin 85.3 2 18089825 (1)
    alpha e 74.4 1 16285732 (1)
    molybdate 66 5 15258137 (2), 16285732 (1), 14580201 (1)
    novobiocin 57.2 3 15209518 (2)
    threonine 36.3 1 16611982 (1)
    serine 26.4 2 18566753 (1), 15082798 (1)
    atp 15 4 19858214 (1), 14701845 (1), 17922836 (1)
    phosphatidylinositol 2.77 1 12176997 (1)
    tyrosine 0 3 16285732 (1), 15258137 (1), 14580201 (1)



    CDC37 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC37 gene: 
    NM_007065.3  

    Unigene Cluster for CDC37:

    Cell division cycle 37
    Hs.160958  [show with all ESTs]
    Unigene Representative Sequence: NM_007065
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222005(uc002mof.1) ENST00000591248 ENST00000589625 ENST00000589331
    ENST00000590632 ENST00000589629 ENST00000593124 ENST00000589755 ENST00000588498
    ENST00000588869

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    8 qRT-PCR Assays for microRNAs that regulate CDC37:
    hsa-miR-34b* hsa-miR-1271 hsa-miR-888 hsa-miR-182 hsa-miR-330-3p hsa-miR-96 hsa-miR-449c hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDC37 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat CDC37

    Additional mRNA sequence: 

    BC000083.2 BC008793.2 BC127212.1 BC127213.1 BC141928.1 BC141929.1 BT006796.1 CR542249.1 
    U43077.1 U63131.1 

    20 DOTS entries:

    DT.100674958  DT.455787  DT.100846570  DT.100762554  DT.100674949  DT.100874359  DT.100674966  DT.455786 
    DT.99977587  DT.95084816  DT.100674964  DT.121480552  DT.100674943  DT.95324945  DT.100674965  DT.121480503 
    DT.100644635  DT.100767423  DT.92049452  DT.95363406 

    Selected AceView cDNA sequences (see all 760):

    BI770534 BQ719687 BQ278617 BU521614 CR623169 BU163680 CR595404 BC000083 
    CR592579 CR604866 BI832529 BE677065 CN483747 BM853748 CR591154 BU944097 
    BQ639808 BQ232038 BQ225907 AI356173 BX362776 AI871349 BQ679865 BU177573 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC37 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -                       -                                                                                                                     
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                              -                                       
    SP5:        -                       -                                                                                                                     


    ECgene alternative splicing isoforms for CDC37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDC37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGCTGCA
    CDC37 Expression
    About this image


    CDC37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    CDC37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.160958
        Custom PCR Arrays for CDC37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDC37 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc371 , 5 cell division cycle 37 homolog (S. cerevisiae)5
    cell division cycle 371
    88.27(n)1
    95.24(a)1
      9 (7.72 cM)5
    125391  NM_016742.41  NP_058022.11 
     211385415 
    lizard
    (Anolis carolinensis)
    Reptilia CDC376
    cell division cycle 37
    81(a)
    1 ↔ 1
    2(27903393-27925752)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdc37-prov2 CDC37 cell division cycle 37 homolog (S. cerevisiae) 78.88(n)    BC041715.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562102 similar to cell division cycle 37 homolog (S. cerevisiae) 81.48(n)   394013  BC045994.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdc371 , 3 protein kinase cascade co-chaperone3
    Cdc371
    52(a)3
    63.18(n)1
    53.39(a)1
      3 62B43
    382321  NM_057658.51  NP_477006.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W08F4.83
    cdc-371
    cdc-371 38(a)3
    53.95(n)1
    41.24(a)1
      II(578085-579883)3
    1734491  NM_001047356.31  NP_001040821.11 


    ENSEMBL Gene Tree for CDC37 (if available)
    TreeFam Gene Tree for CDC37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC37 gene
    CDC37L12  
    2 SIMAP similar genes for CDC37 using alignment to 7 protein entries:     CDC37_HUMAN (see all proteins):
    MBD5    CDC37L1

    CDC37 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CDC37
    PGOHUM00000259034 PGOHUM00000259108 PGOHUM00000235440


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC37 (see all 295)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454175751,2
    --10501609(+) GGTGGA/GTGAGA 1 -- ds50010--------
    rs1464894511,2
    --10501640(+) AGGCCA/TCTGGA 1 -- ds50010--------
    rs126112271,2
    C,F,A,H--10501740(+) CCCCAA/GTATCC 1 -- ds500128Minor allele frequency- G:0.38NS EA NA WA CSA 2538
    rs1412744531,2
    --10501741(+) CCCAAC/TATCCC 1 -- ds50010--------
    rs795070391,2
    F--10501757(+) GTTTCC/ACTCCC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1139727401,2
    C--10501808(+) CCCAGA/C/TGAGCA 1 -- ds50011CSA 1
    rs1502184351,2
    C--10501839(+) GATCAC/TTGCTG 1 -- ut310--------
    rs1870706051,2
    --10501898(+) CCAGTA/GACGAG 1 -- ut310--------
    rs1923592731,2
    --10501920(+) TGGCTA/GGGGAC 1 -- ut310--------
    rs283827951,2
    C--10501982(-) AGGCCC/TGGGGG 1 -- ut31 ese36Minor allele frequency- T:0.00NS NA 190

    HapMap Linkage Disequilibrium report for CDC37 (10501809 - 10530797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDC37:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911041CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv518008CNV Gain19592680
    esv24860CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC37
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605065    OMIM disorders: --

    18 diseases for CDC37:    
    About MalaCards
    peutz-jeghers syndrome    chondrosarcoma    acute leukemia    multiple myeloma
    myeloma    parkinson's disease    prostate cancer    multiple sclerosis
    prostatitis    pancreatic cancer    inflammatory bowel disease    pancreatitis
    alzheimer's disease    melanoma    hiv-1    adenocarcinoma
    malaria    leukemia


    CDC37 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for CDC37 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57.2 13 12727831 (1), 20226165 (1), 17728246 (1), 19703551 (1) (see all 11)
    cancer 19.4 18 18931700 (3), 19177013 (3), 19387550 (1), 15661534 (1) (see all 6)
    tumors 3.34 7 19387550 (1), 10822368 (1), 18089825 (1), 18922470 (1)
    prostate cancer 0 5 10822368 (2), 18089825 (1), 12907640 (1)
    hyperplasia 0 1 12907640 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDC37 (1 document)

    Export disorders for CDC37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC37 gene, integrated from 10 sources (see all 174):
    (articles sorted by number of sources associating them with CDC37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. (PubMed id 8666233)1, 2, 3 Stepanova L.... Harper J.W. (Genes Dev. 1996)
    2. Physical interaction of mammalian CDC37 with CDK4. (PubMed id 8703009)1, 2, 3 Dai K.... Beach D. (J. Biol. Chem. 1996)
    3. Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase. (PubMed id 11036079)1, 2, 9 Shao J.... Matts R.L. (J. Biol. Chem. 2001)
    4. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. (PubMed id 11085988)1, 2, 9 Rao J....Caplan A.J. (J. Biol. Chem. 2001)
    5. Interaction between Cdc37 and Cdk4 in human cells. (PubMed id 9150368)1, 2, 9 Lamphere L.... Gyuris J. (Oncogene 1997)
    6. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (Nucleic Acids Res. 2007)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. (PubMed id 10858314)1, 2 Hartson S.D....Matts R.L. (Biochemistry 2000)
    10. CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. (PubMed id 15082798)1, 9 Miyata Y. and Nishida E. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11140 HGNC: 1735 AceView: CDC37 Ensembl:ENSG00000105401 euGenes: HUgn11140
    ECgene: CDC37 Kegg: 11140 H-InvDB: CDC37

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC37 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC37 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc37/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC37 gene:
    Search GeneIP for patents involving CDC37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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