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Aliases for CDC27 Gene

Aliases for CDC27 Gene

  • Cell Division Cycle 27 2 3 5
  • Anaphase Promoting Complex Subunit 3 2 3
  • D0S1430E 3 4
  • D17S978E 3 4
  • CDC27Hs 3 4
  • ANAPC3 3 4
  • H-NUC 3 4
  • APC3 3 4
  • Cell Division Cycle 27 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 27 Homolog 3
  • Anaphase-Promoting Complex, Protein 3 3
  • Anaphase-Promoting Complex Subunit 3 4
  • Cell Division Cycle 27 Homolog 3
  • CDC27 Homolog 4
  • Nuc2 Homolog 3
  • HNUC 3
  • NUC2 3

External Ids for CDC27 Gene

Previous HGNC Symbols for CDC27 Gene

  • D0S1430E
  • D17S978E

Previous GeneCards Identifiers for CDC27 Gene

  • GC17M044695
  • GC17M047596
  • GC17M045539
  • GC17M045672
  • GC17M042552
  • GC17M045195
  • GC17M040572

Summaries for CDC27 Gene

Entrez Gene Summary for CDC27 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

GeneCards Summary for CDC27 Gene

CDC27 (Cell Division Cycle 27) is a Protein Coding gene. Diseases associated with CDC27 include Cervix Carcinoma and Breast Cancer. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and APC-Cdc20 mediated degradation of Nek2A. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for CDC27 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC27 Gene

Genomics for CDC27 Gene

Regulatory Elements for CDC27 Gene

Enhancers for CDC27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G047069 1.5 Ensembl ENCODE 38.1 +118.2 118219 4.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ARL17B MRPL45P2 KANSL1 LOC101927060 CDC27 ENSG00000266601 LRRC37A17P ENSG00000264701 RPS2P47 ENSG00000253347
GH17G047203 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -16.2 -16158 4.3 HDGF PKNOX1 WRNIP1 SIN3A TCF12 ZNF121 FOS ZNF263 JUNB TBX21 CDC27 SCRN2 KANSL1 ARL17B RNU7-186P EFCAB13 RPS2P47 MRPL45P2 RPRML LOC101927060
GH17G047222 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -35.5 -35493 4.1 HDGF SIN3A YBX1 ZNF121 ZNF766 GATA2 ZNF143 FOS TBX21 ZNF518A CDC27 MYL4 RNU7-186P EFCAB13 LOC101927060 ITGB3
GH17G047187 1.4 ENCODE dbSUPER 22.3 -0.2 -184 4.0 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CDC27 LOC101927060 KANSL1 MYL4
GH17G047119 1.1 ENCODE 21.7 +69.0 68965 2.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ZNF207 CDC27 LOC101927060 MYL4 MRPL45P2 ENSG00000253347 RPS7P11 PIR31926
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC27 on UCSC Golden Path with GeneCards custom track

Promoters for CDC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095147 622 2401 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for CDC27 Gene

Chromosome:
17
Start:
47,117,697 bp from pter
End:
47,189,422 bp from pter
Size:
71,726 bases
Orientation:
Minus strand

Genomic View for CDC27 Gene

Genes around CDC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC27 Gene

Proteins for CDC27 Gene

  • Protein details for CDC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30260-CDC27_HUMAN
    Recommended name:
    Cell division cycle protein 27 homolog
    Protein Accession:
    P30260
    Secondary Accessions:
    • G3V1C4
    • Q16349
    • Q96F35

    Protein attributes for CDC27 Gene

    Size:
    824 amino acids
    Molecular mass:
    91867 Da
    Quaternary structure:
    • Homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1.

    Three dimensional structures from OCA and Proteopedia for CDC27 Gene

    Alternative splice isoforms for CDC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC27 Gene

Post-translational modifications for CDC27 Gene

  • Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
  • Ubiquitination at Lys99, Lys588, Lys694, and Lys735
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDC27 Gene

Domains & Families for CDC27 Gene

Protein Domains for CDC27 Gene

Suggested Antigen Peptide Sequences for CDC27 Gene

Graphical View of Domain Structure for InterPro Entry

P30260

UniProtKB/Swiss-Prot:

CDC27_HUMAN :
  • Belongs to the APC3/CDC27 family.
Family:
  • Belongs to the APC3/CDC27 family.
genes like me logo Genes that share domains with CDC27: view

Function for CDC27 Gene

Molecular function for CDC27 Gene

GENATLAS Biochemistry:
cell division cycle 27,human homolog of S cerevisiae,yeast cdc27,component of the anaphase promoting complex that control anaphase initiation and late mitotic events
UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16648845
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with CDC27: view
genes like me logo Genes that share phenotypes with CDC27: view

Animal Model Products

CRISPR Products

miRNA for CDC27 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDC27

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC27 Gene

Localization for CDC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC27 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS,IDA --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 7736578
genes like me logo Genes that share ontologies with CDC27: view

Pathways & Interactions for CDC27 Gene

SuperPathways for CDC27 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence
genes like me logo Genes that share pathways with CDC27: view

UniProtKB/Swiss-Prot P30260-CDC27_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC27 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 7736578
GO:0008283 cell proliferation TAS 7736578
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with CDC27: view

Transcripts for CDC27 Gene

Unigene Clusters for CDC27 Gene

Cell division cycle 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDC27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC27 Gene

No ASD Table

Relevant External Links for CDC27 Gene

GeneLoc Exon Structure for
CDC27
ECgene alternative splicing isoforms for
CDC27

Expression for CDC27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC27 Gene

Protein differential expression in normal tissues from HIPED for CDC27 Gene

This gene is overexpressed in Lung (24.5), Placenta (14.9), and Breast (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC27 Gene



Protein tissue co-expression partners for CDC27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC27 Gene:

CDC27

SOURCE GeneReport for Unigene cluster for CDC27 Gene:

Hs.463295

Evidence on tissue expression from TISSUES for CDC27 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with CDC27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC27 Gene

Orthologs for CDC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC27 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia CDC27 34 35
  • 97.17 (n)
cow
(Bos Taurus)
Mammalia CDC27 34 35
  • 96.52 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC27 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc27 34 16 35
  • 92.92 (n)
rat
(Rattus norvegicus)
Mammalia Cdc27 34
  • 92.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC27 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC27 34 35
  • 86.27 (n)
lizard
(Anolis carolinensis)
Reptilia CDC27 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc27 34
  • 78.43 (n)
Str.17164 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14864 34
zebrafish
(Danio rerio)
Actinopterygii cdc27 34 35
  • 72.19 (n)
wufb54g06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5705 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007690 34
  • 51.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cdc27 36 34 35
  • 49.35 (n)
worm
(Caenorhabditis elegans)
Secernentea mat-1 35
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC27 35 37
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons HBT 34
  • 51.56 (n)
rice
(Oryza sativa)
Liliopsida Os06g0622500 34
  • 47.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.74 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4019 34
Species where no ortholog for CDC27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC27 Gene

ENSEMBL:
Gene Tree for CDC27 (if available)
TreeFam:
Gene Tree for CDC27 (if available)

Paralogs for CDC27 Gene

No data available for Paralogs for CDC27 Gene

Variants for CDC27 Gene

Sequence variations from dbSNP and Humsavar for CDC27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_035861 A breast cancer sample
rs1000033037 -- 47,151,612(+) TAACT(A/G)TTGTC intron-variant
rs1000068813 -- 47,128,659(+) GGAAA(A/G)ATGAT intron-variant
rs1000136271 -- 47,145,054(+) AAAAC(C/T)TTCTA intron-variant
rs1000141689 -- 47,178,783(+) GTATC(C/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC27 Gene

Variant ID Type Subtype PubMed ID
dgv417e201 CNV deletion 23290073
dgv418e201 CNV deletion 23290073
dgv419e201 CNV deletion 23290073
dgv41n68 CNV loss 17160897
dgv420e201 CNV deletion 23290073
dgv421e201 CNV deletion 23290073
dgv422e201 CNV deletion 23290073
dgv423e201 CNV deletion 23290073
dgv532n67 CNV gain 20364138
dgv65e19 CNV loss 19470904
esv1725912 CNV insertion 17803354
esv22671 CNV gain 19812545
esv2543466 CNV insertion 19546169
esv2655194 CNV gain 19546169
esv2715978 CNV deletion 23290073
esv2715987 CNV deletion 23290073
esv2715988 CNV deletion 23290073
esv2715992 CNV deletion 23290073
esv2715993 CNV deletion 23290073
esv2716009 CNV deletion 23290073
esv2742082 CNV deletion 23290073
esv2758692 CNV gain+loss 17122850
esv2760450 CNV gain 21179565
esv2990 CNV loss 18987735
esv3411051 CNV duplication 20981092
esv3426884 CNV insertion 20981092
esv3435421 CNV duplication 20981092
esv3584 OTHER complex 18987735
esv3790 CNV loss 18987735
esv4309 OTHER complex 18987735
esv4323 CNV loss 18987735
esv4562 CNV loss 18987735
esv4785 OTHER complex 18987735
esv4896 CNV loss 18987735
esv5454 CNV loss 19470904
esv5729 CNV loss 19470904
esv6177 CNV loss 19470904
esv6495 CNV loss 19470904
esv6742 CNV loss 19470904
esv7557 CNV loss 19470904
esv7866 CNV loss 19470904
esv8272 CNV loss 19470904
esv8768 CNV loss 19470904
nsv1059766 CNV gain 25217958
nsv1127577 CNV deletion 24896259
nsv1138548 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv513476 CNV insertion 21212237
nsv521632 CNV gain 19592680
nsv955389 CNV deletion 24416366
nsv955402 CNV deletion 24416366
nsv955412 CNV deletion 24416366
nsv955428 CNV deletion 24416366
nsv960117 CNV duplication 23825009
nsv960498 CNV duplication 23825009
nsv962332 CNV duplication 23825009
nsv962333 CNV duplication 23825009
nsv978432 CNV duplication 23825009

Variation tolerance for CDC27 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC27 Gene

Disorders for CDC27 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDC27 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cervical cancer
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CDC27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC27

Genetic Association Database (GAD)
CDC27
Human Genome Epidemiology (HuGE) Navigator
CDC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC27
genes like me logo Genes that share disorders with CDC27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC27 Gene

Publications for CDC27 Gene

  1. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. (PMID: 7756179) Chen P.L. … Lee W.H. (Cell Growth Differ. 1995) 3 4 22 64
  2. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. (PMID: 8234252) Tugendreich S. … Hieter P.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
  4. Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex. (PMID: 22139841) Singh N. … Couch F.J. (J. Biol. Chem. 2012) 3 4 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for CDC27 Gene

Sources for CDC27 Gene

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