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Aliases for CDC27 Gene

Aliases for CDC27 Gene

  • Cell Division Cycle 27 2 3 5
  • Anaphase Promoting Complex Subunit 3 2 3
  • D0S1430E 3 4
  • D17S978E 3 4
  • CDC27Hs 3 4
  • ANAPC3 3 4
  • H-NUC 3 4
  • APC3 3 4
  • Cell Division Cycle 27 Homolog (S. Cerevisiae) 2
  • Anaphase-Promoting Complex, Protein 3 3
  • Anaphase-Promoting Complex Subunit 3 4
  • Cell Division Cycle 27 Homolog 3
  • CDC27 Homolog 4
  • Nuc2 Homolog 3
  • HNUC 3
  • NUC2 3

External Ids for CDC27 Gene

Previous HGNC Symbols for CDC27 Gene

  • D0S1430E
  • D17S978E

Previous GeneCards Identifiers for CDC27 Gene

  • GC17M044695
  • GC17M047596
  • GC17M045539
  • GC17M045672
  • GC17M042552
  • GC17M045195
  • GC17M040572

Summaries for CDC27 Gene

Entrez Gene Summary for CDC27 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

GeneCards Summary for CDC27 Gene

CDC27 (Cell Division Cycle 27) is a Protein Coding gene. Diseases associated with CDC27 include cervix carcinoma and breast cancer. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for CDC27 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC27 Gene

Genomics for CDC27 Gene

Regulatory Elements for CDC27 Gene

Promoters for CDC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC27 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC27 Gene

Chromosome:
17
Start:
47,117,697 bp from pter
End:
47,189,422 bp from pter
Size:
71,726 bases
Orientation:
Minus strand

Genomic View for CDC27 Gene

Genes around CDC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC27 Gene

Proteins for CDC27 Gene

  • Protein details for CDC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30260-CDC27_HUMAN
    Recommended name:
    Cell division cycle protein 27 homolog
    Protein Accession:
    P30260
    Secondary Accessions:
    • G3V1C4
    • Q16349
    • Q96F35

    Protein attributes for CDC27 Gene

    Size:
    824 amino acids
    Molecular mass:
    91867 Da
    Quaternary structure:
    • Homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1.

    Three dimensional structures from OCA and Proteopedia for CDC27 Gene

    Alternative splice isoforms for CDC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC27 Gene

Proteomics data for CDC27 Gene at MOPED

Post-translational modifications for CDC27 Gene

  • Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
  • Ubiquitination at Lys 99, Lys 588, Lys 694, and Lys 735
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC27 (CDC27)

No data available for DME Specific Peptides for CDC27 Gene

Domains & Families for CDC27 Gene

Protein Domains for CDC27 Gene

Suggested Antigen Peptide Sequences for CDC27 Gene

Graphical View of Domain Structure for InterPro Entry

P30260

UniProtKB/Swiss-Prot:

CDC27_HUMAN :
  • Belongs to the APC3/CDC27 family.
  • Contains 13 TPR repeats.
Family:
  • Belongs to the APC3/CDC27 family.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with CDC27: view

Function for CDC27 Gene

Molecular function for CDC27 Gene

GENATLAS Biochemistry:
cell division cycle 27,human homolog of S cerevisiae,yeast cdc27,component of the anaphase promoting complex that control anaphase initiation and late mitotic events
UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
genes like me logo Genes that share phenotypes with CDC27: view

Animal Model Products

miRNA for CDC27 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC27 Gene

Localization for CDC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC27 Gene COMPARTMENTS Subcellular localization image for CDC27 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005737 cytoplasm IDA --
GO:0005819 spindle TAS 7736578
GO:0005829 cytosol TAS --
GO:0005876 colocalizes_with spindle microtubule IDA 7736578
genes like me logo Genes that share ontologies with CDC27: view

Pathways & Interactions for CDC27 Gene

SuperPathways for CDC27 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cellular Senescence
4 Cell Cycle, Mitotic
.61
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with CDC27: view

UniProtKB/Swiss-Prot P30260-CDC27_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC27 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 7736578
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDC27: view

Drugs & Compounds for CDC27 Gene

No Compound Related Data Available

Transcripts for CDC27 Gene

Unigene Clusters for CDC27 Gene

Cell division cycle 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC27 Gene

No ASD Table

Relevant External Links for CDC27 Gene

GeneLoc Exon Structure for
CDC27
ECgene alternative splicing isoforms for
CDC27

Expression for CDC27 Gene

mRNA expression in normal human tissues for CDC27 Gene

Protein differential expression in normal tissues from HIPED for CDC27 Gene

This gene is overexpressed in Lung (24.5), Placenta (14.9), and Breast (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC27 Gene



SOURCE GeneReport for Unigene cluster for CDC27 Gene Hs.463295

genes like me logo Genes that share expression patterns with CDC27: view

Protein tissue co-expression partners for CDC27 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC27 Gene

Orthologs for CDC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC27 35
  • 96.52 (n)
  • 99.15 (a)
CDC27 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC27 35
  • 97.17 (n)
  • 99.27 (a)
CDC27 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc27 35
  • 92.92 (n)
  • 97.09 (a)
Cdc27 16
Cdc27 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC27 35
  • 99.88 (n)
  • 99.88 (a)
CDC27 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc27 35
  • 92.79 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC27 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC27 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC27 35
  • 86.27 (n)
  • 95.75 (a)
CDC27 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC27 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc27 35
  • 78.43 (n)
  • 91.36 (a)
Str.17164 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14864 35
zebrafish
(Danio rerio)
Actinopterygii cdc27 35
  • 72.19 (n)
  • 81.11 (a)
wufb54g06 35
cdc27 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5705 35
fruit fly
(Drosophila melanogaster)
Insecta Cdc27 37
  • 37 (a)
Cdc27 35
  • 49.35 (n)
  • 45.74 (a)
Cdc27 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007690 35
  • 51.07 (n)
  • 51.64 (a)
worm
(Caenorhabditis elegans)
Secernentea mat-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC27 36
  • 29 (a)
OneToOne
CDC27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HBT 35
  • 51.56 (n)
  • 44.68 (a)
rice
(Oryza sativa)
Liliopsida Os06g0622500 35
  • 47.95 (n)
  • 42.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4019 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.74 36
  • 43 (a)
OneToOne
Species with no ortholog for CDC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC27 Gene

ENSEMBL:
Gene Tree for CDC27 (if available)
TreeFam:
Gene Tree for CDC27 (if available)

Paralogs for CDC27 Gene

Pseudogenes.org Pseudogenes for CDC27 Gene

genes like me logo Genes that share paralogs with CDC27: view

No data available for Paralogs for CDC27 Gene

Variants for CDC27 Gene

Sequence variations from dbSNP and Humsavar for CDC27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_014489 -
VAR_035861 A breast cancer sample
VAR_052613 -
rs188799 -- 47,151,675(-) AATTT(A/G)AAACC intron-variant
rs9979 -- 47,120,835(-) GTGTC(A/G)TCGTC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDC27 Gene

Variant ID Type Subtype PubMed ID
dgv976e1 CNV Complex 17122850
dgv986e1 CNV Complex 17122850
dgv41n68 CNV Loss 17160897
nsv521632 CNV Gain 19592680
nsv908563 CNV Loss 21882294
esv2543466 CNV Insertion 19546169
nsv513476 CNV Insertion 21212237
esv1725912 CNV Insertion 17803354
esv22671 CNV Gain 19812545
esv7866 CNV Loss 19470904
esv2715978 CNV Deletion 23290073
dgv532n67 CNV Gain 20364138
esv2655194 CNV Gain 19546169
esv6742 CNV Loss 19470904
esv5454 CNV Loss 19470904
dgv458e201 CNV Deletion 23290073
dgv459e201 CNV Deletion 23290073
esv4562 CNV Deletion 18987735
esv8768 CNV Loss 19470904
esv2715987 CNV Deletion 23290073
esv4309 CNV Complex 18987735
esv2715988 CNV Deletion 23290073
dgv460e201 CNV Deletion 23290073
esv2742082 CNV Deletion 23290073
esv7557 CNV Loss 19470904
dgv461e201 CNV Deletion 23290073
esv8272 CNV Loss 19470904
esv4896 CNV Deletion 18987735
esv2715992 CNV Deletion 23290073
esv2715993 CNV Deletion 23290073
esv6177 CNV Loss 19470904
dgv462e201 CNV Deletion 23290073
dgv463e201 CNV Deletion 23290073
dgv464e201 CNV Deletion 23290073
esv5729 CNV Loss 19470904
esv2990 CNV Deletion 18987735
esv3584 CNV Complex 18987735
esv3790 CNV Deletion 18987735
esv6495 CNV Loss 19470904
dgv56e19 CNV Loss 19470904
esv2716009 CNV Deletion 23290073
esv4785 CNV Complex 18987735
esv4323 CNV Deletion 18987735

Variation tolerance for CDC27 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC27 Gene

HapMap Linkage Disequilibrium report
CDC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC27 Gene

Disorders for CDC27 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDC27 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervix carcinoma
  • cancer of cervix
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CDC27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC27

Genetic Association Database (GAD)
CDC27
Human Genome Epidemiology (HuGE) Navigator
CDC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC27
genes like me logo Genes that share disorders with CDC27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC27 Gene

Publications for CDC27 Gene

  1. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. (PMID: 8234252) Tugendreich S. … Hieter P.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 67
  2. A novel function for HSF1-induced mitotic exit failure and genomic instability through direct interaction between HSF1 and Cdc20. (PMID: 18059335) Lee Y.J. … Lee Y.S. (Oncogene 2008) 3 23
  3. The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome. (PMID: 17827148) Coster G. … Goldberg M. (J. Biol. Chem. 2007) 3 23
  4. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. (PMID: 12853486) Gabellini D. … Peverali F.A. (EMBO J. 2003) 3 23
  5. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. (PMID: 12429948) Topper L.M. … Gorbsky G.J. (Cell Cycle 2002) 3 23

Products for CDC27 Gene

Sources for CDC27 Gene

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