Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDC27 Gene

Aliases for CDC27 Gene

  • Cell Division Cycle 27 2 3
  • Anaphase Promoting Complex Subunit 3 2 3
  • D0S1430E 3 4
  • D17S978E 3 4
  • CDC27Hs 3 4
  • ANAPC3 3 4
  • H-NUC 3 4
  • APC3 3 4
  • Cell Division Cycle 27 Homolog (S. Cerevisiae) 2
  • Anaphase-Promoting Complex, Protein 3 3
  • Anaphase-Promoting Complex Subunit 3 4
  • Cell Division Cycle 27 Homolog 3
  • CDC27 Homolog 4
  • Nuc2 Homolog 3
  • HNUC 3
  • NUC2 3

External Ids for CDC27 Gene

Previous HGNC Symbols for CDC27 Gene

  • D0S1430E
  • D17S978E

Previous GeneCards Identifiers for CDC27 Gene

  • GC17M044695
  • GC17M047596
  • GC17M045539
  • GC17M045672
  • GC17M042552
  • GC17M045195
  • GC17M040572

Summaries for CDC27 Gene

Entrez Gene Summary for CDC27 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

GeneCards Summary for CDC27 Gene

CDC27 (Cell Division Cycle 27) is a Protein Coding gene. Diseases associated with CDC27 include breast cancer. Among its related pathways are Immune System and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for CDC27 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC27 Gene

Genomics for CDC27 Gene

Regulatory Elements for CDC27 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC27 Gene

Chromosome:
17
Start:
47,117,697 bp from pter
End:
47,189,422 bp from pter
Size:
71,726 bases
Orientation:
Minus strand

Genomic View for CDC27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC27 Gene

Proteins for CDC27 Gene

  • Protein details for CDC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30260-CDC27_HUMAN
    Recommended name:
    Cell division cycle protein 27 homolog
    Protein Accession:
    P30260
    Secondary Accessions:
    • G3V1C4
    • Q16349
    • Q96F35

    Protein attributes for CDC27 Gene

    Size:
    824 amino acids
    Molecular mass:
    91867 Da
    Quaternary structure:
    • Homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1.

    Three dimensional structures from OCA and Proteopedia for CDC27 Gene

    Alternative splice isoforms for CDC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC27 Gene

Proteomics data for CDC27 Gene at MOPED

Post-translational modifications for CDC27 Gene

  • Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
  • Ubiquitination at Lys 99, Lys 588, Lys 694, and Lys 735
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC27 (CDC27)

No data available for DME Specific Peptides for CDC27 Gene

Domains & Families for CDC27 Gene

Protein Domains for CDC27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC27 Gene

Graphical View of Domain Structure for InterPro Entry

P30260

UniProtKB/Swiss-Prot:

CDC27_HUMAN :
  • Belongs to the APC3/CDC27 family.
  • Contains 13 TPR repeats.
Family:
  • Belongs to the APC3/CDC27 family.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with CDC27: view

Function for CDC27 Gene

Molecular function for CDC27 Gene

GENATLAS Biochemistry:
cell division cycle 27,human homolog of S cerevisiae,yeast cdc27,component of the anaphase promoting complex that control anaphase initiation and late mitotic events
UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16648845
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with CDC27: view
genes like me logo Genes that share phenotypes with CDC27: view

Animal Model Products

miRNA for CDC27 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC27 Gene

Localization for CDC27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC27 Gene COMPARTMENTS Subcellular localization image for CDC27 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 7736578
genes like me logo Genes that share ontologies with CDC27: view

Pathways & Interactions for CDC27 Gene

SuperPathways for CDC27 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Separation of Sister Chromatids
3 APC-Cdc20 mediated degradation of Nek2A
4 Cell Cycle, Mitotic
.62
5 Cellular Senescence
genes like me logo Genes that share pathways with CDC27: view

PCR Array Products

UniProtKB/Swiss-Prot P30260-CDC27_HUMAN

  • Pathway: Protein modification; protein ubiquitination

SIGNOR curated interactions for CDC27 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 7736578
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0008283 cell proliferation TAS 7736578
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with CDC27: view

Drugs & Compounds for CDC27 Gene

No Compound Related Data Available

Transcripts for CDC27 Gene

Unigene Clusters for CDC27 Gene

Cell division cycle 27:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC27 Gene

No ASD Table

Relevant External Links for CDC27 Gene

GeneLoc Exon Structure for
CDC27
ECgene alternative splicing isoforms for
CDC27

Expression for CDC27 Gene

mRNA expression in normal human tissues for CDC27 Gene

Protein differential expression in normal tissues from HIPED for CDC27 Gene

This gene is overexpressed in Lung (24.5), Placenta (14.9), and Breast (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC27 Gene



SOURCE GeneReport for Unigene cluster for CDC27 Gene Hs.463295

genes like me logo Genes that share expression patterns with CDC27: view

Protein tissue co-expression partners for CDC27 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC27 Gene

Orthologs for CDC27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC27 35
  • 96.52 (n)
  • 99.15 (a)
CDC27 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC27 35
  • 97.17 (n)
  • 99.27 (a)
CDC27 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc27 35
  • 92.92 (n)
  • 97.09 (a)
Cdc27 16
Cdc27 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC27 35
  • 99.88 (n)
  • 99.88 (a)
CDC27 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc27 35
  • 92.79 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC27 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC27 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC27 35
  • 86.27 (n)
  • 95.75 (a)
CDC27 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC27 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc27 35
  • 78.43 (n)
  • 91.36 (a)
Str.17164 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14864 35
zebrafish
(Danio rerio)
Actinopterygii cdc27 35
  • 72.19 (n)
  • 81.11 (a)
wufb54g06 35
cdc27 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5705 35
fruit fly
(Drosophila melanogaster)
Insecta Cdc27 37
  • 37 (a)
Cdc27 35
  • 49.35 (n)
  • 45.74 (a)
Cdc27 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007690 35
  • 51.07 (n)
  • 51.64 (a)
worm
(Caenorhabditis elegans)
Secernentea mat-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC27 36
  • 29 (a)
OneToOne
CDC27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HBT 35
  • 51.56 (n)
  • 44.68 (a)
rice
(Oryza sativa)
Liliopsida Os06g0622500 35
  • 47.95 (n)
  • 42.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4019 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.74 36
  • 43 (a)
OneToOne
Species with no ortholog for CDC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC27 Gene

ENSEMBL:
Gene Tree for CDC27 (if available)
TreeFam:
Gene Tree for CDC27 (if available)

Paralogs for CDC27 Gene

Pseudogenes.org Pseudogenes for CDC27 Gene

genes like me logo Genes that share paralogs with CDC27: view

No data available for Paralogs for CDC27 Gene

Variants for CDC27 Gene

Sequence variations from dbSNP and Humsavar for CDC27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1612 -- 47,178,214(+) aaaat(A/G)ttaga intron-variant
rs9979 -- 47,120,835(-) GTGTC(A/G)TCGTC utr-variant-3-prime, nc-transcript-variant
rs183402 -- 47,173,894(-) GCTGG(G/T)CTTGA intron-variant
rs188799 -- 47,151,675(-) AATTT(A/G)AAACC intron-variant
rs221596 -- 47,152,945(-) TTGAA(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC27 Gene

Variant ID Type Subtype PubMed ID
dgv976e1 CNV Complex 17122850
dgv986e1 CNV Complex 17122850
dgv41n68 CNV Loss 17160897
nsv521632 CNV Gain 19592680
nsv908563 CNV Loss 21882294
esv2543466 CNV Insertion 19546169
nsv513476 CNV Insertion 21212237
esv1725912 CNV Insertion 17803354
esv22671 CNV Gain 19812545
esv7866 CNV Loss 19470904
esv2715978 CNV Deletion 23290073
dgv532n67 CNV Gain 20364138
esv2655194 CNV Gain 19546169
esv6742 CNV Loss 19470904
esv5454 CNV Loss 19470904
dgv458e201 CNV Deletion 23290073
dgv459e201 CNV Deletion 23290073
esv4562 CNV Deletion 18987735
esv8768 CNV Loss 19470904
esv2715987 CNV Deletion 23290073
esv4309 CNV Complex 18987735
esv2715988 CNV Deletion 23290073
dgv460e201 CNV Deletion 23290073
esv2742082 CNV Deletion 23290073
esv7557 CNV Loss 19470904
dgv461e201 CNV Deletion 23290073
esv8272 CNV Loss 19470904
esv4896 CNV Deletion 18987735
esv2715992 CNV Deletion 23290073
esv2715993 CNV Deletion 23290073
esv6177 CNV Loss 19470904
dgv462e201 CNV Deletion 23290073
dgv463e201 CNV Deletion 23290073
dgv464e201 CNV Deletion 23290073
esv5729 CNV Loss 19470904
esv2990 CNV Deletion 18987735
esv3584 CNV Complex 18987735
esv3790 CNV Deletion 18987735
esv6495 CNV Loss 19470904
dgv56e19 CNV Loss 19470904
esv2716009 CNV Deletion 23290073
esv4785 CNV Complex 18987735
esv4323 CNV Deletion 18987735

Variation tolerance for CDC27 Gene

Residual Variation Intolerance Score: 99.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC27 Gene

HapMap Linkage Disequilibrium report
CDC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC27 Gene

Disorders for CDC27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC27 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association
Search CDC27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC27

Genetic Association Database (GAD)
CDC27
Human Genome Epidemiology (HuGE) Navigator
CDC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC27
genes like me logo Genes that share disorders with CDC27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC27 Gene

Publications for CDC27 Gene

  1. Arsenic trioxide suppresses paclitaxel-induced mitotic arrest. (PMID: 19397590) Duan Q. … Dai W. (Cell Prolif. 2009) 23 67
  2. Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis. (PMID: 19686603) Sanchez Garcia J. … MacNeill S.A. (BMC Mol. Biol. 2009) 23 67
  3. A novel function for HSF1-induced mitotic exit failure and genomic instability through direct interaction between HSF1 and Cdc20. (PMID: 18059335) Lee Y.J. … Lee Y.S. (Oncogene 2008) 23 67
  4. Cdk1 phosphorylation sites on Cdc27 are required for correct chromosomal localisation and APC/C function in syncytial Drosophila embryos. (PMID: 17519285) Huang J.Y. … Whitaker M. (J. Cell. Sci. 2007) 23 67
  5. The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome. (PMID: 17827148) Coster G. … Goldberg M. (J. Biol. Chem. 2007) 23 67

Products for CDC27 Gene

Sources for CDC27 Gene

Back to Top

Content