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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC27 Gene

protein-coding   GIFtS: 65
GCID: GC17M045195

Cell Division Cycle 27

(Previous names: cell division cycle 27, cell division cycle 27 homolog (S....)
(Previous symbols: D0S1430E, D17S978E)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 271 2     CDC27 Homolog2 3
D0S1430E1 2 3     Cell Division Cycle 27 Homolog (S. Cerevisiae)1
D17S978E1 2 3     HNUC2
Anaphase Promoting Complex Subunit 31 2     NUC22
Anaphase-Promoting Complex Subunit 32 3     Anaphase-Promoting Complex, Protein 32
ANAPC32 3     Cell Division Cycle 27 Homolog2
APC32 3     Cell Division Cycle Protein 27 Homolog2
CDC27Hs2 3     Nuc2 Homolog2
H-NUC2 3     

External Ids:    HGNC: 17281   Entrez Gene: 9962   Ensembl: ENSG000000048977   OMIM: 1169465   UniProtKB: P302603   

Export aliases for CDC27 gene to outside databases

Previous GC identifers: GC17M044695 GC17M047596 GC17M045539 GC17M045672 GC17M042552 GC17M040572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC27 Gene:
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the
gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC),
which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation
of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins.
This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain
important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins
including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for CDC27 Gene: 
CDC27 (cell division cycle 27) is a protein-coding gene. Diseases associated with CDC27 include herpes simplex, and cytomegalovirus infection, and among its related super-pathways are Mitotic Spindle Checkpoint and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include protein binding and protein phosphatase binding.

UniProtKB/Swiss-Prot: CDC27_HUMAN, P30260
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for CDC27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC27 gene promoter:
         c-Rel   GATA-3   NF-kappaB2   Zic1   Hand1   RelA   NF-kappaB1   NF-kappaB   Zic3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC27 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

CDC27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC27 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M045195:  view genomic region     (about GC identifiers)

Start:
45,195,069 bp from pter      End:
45,266,788 bp from pter
Size:
71,720 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDC27_HUMAN, P30260 (See protein sequence)
Recommended Name: Cell division cycle protein 27 homolog  
Size: 824 amino acids; 91867 Da
Subunit: The APC/C is composed of at least 12 subunits. Interacts with RB. Interacts with FAM168B/MANI (By
similarity). Interacts with MCPH1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for CDC27:
3T1N (3D)    
Secondary accessions: G3V1C4 Q16349 Q96F35
Alternative splicing: 2 isoforms:  P30260-1   P30260-2   (No experimental confirmation available. May be due to competing acceptor splice site)

Explore the universe of human proteins at neXtProt for CDC27: NX_P30260

Explore proteomics data for CDC27 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30260

  • CDC27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC27 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001107563.1  NP_001247.3  

    ENSEMBL proteins: 
     ENSP00000066544   ENSP00000434614   ENSP00000460830   ENSP00000432211   ENSP00000460279  
     ENSP00000437339   ENSP00000432105   ENSP00000460132   ENSP00000458904   ENSP00000459307  
     ENSP00000460424   ENSP00000460061   ENSP00000460454   ENSP00000466424   ENSP00000392802  
    Reactome Protein details: P30260
    Human Recombinant Protein Products for CDC27: 
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    Novus Biologicals CDC27 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC27 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CDC27 for ontologies           About GeneDecksing



    CDC27 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANAPC: Anaphase promoting complex subunits
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR026803 CDC27
     IPR001440 TPR-1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P30260

    ProtoNet protein and cluster: P30260

    UniProtKB/Swiss-Prot: CDC27_HUMAN, P30260
    Similarity: Belongs to the APC3/CDC27 family
    Similarity: Contains 9 TPR repeats


    CDC27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC27_HUMAN, P30260
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Genatlas biochemistry entry for CDC27:
    cell division cycle 27,human homolog of S cerevisiae,yeast cdc27,component of the anaphase promoting complex that
    control anaphase initiation and late mitotic events

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16648845
    GO:0019903protein phosphatase binding IPI--
         
    CDC27 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDC27:
     Cell division defect  Increased S DNA content, incre  Increased cell death HMECs cel  Increased cell death in breast 
     Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
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    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-15a hsa-miR-605 hsa-miR-208b hsa-miR-4325 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCDC27 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC27 About   (see all 24)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Mitotic Spindle Checkpoint0.95
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    Phosphorylation of the APC/C0.73
    APC-Cdc20 mediated degradation of Nek2A0.78
    Common schema of ubiquitination0.36
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    APC/C-mediated degradation of cell cycle proteins0.94
    Autodegradation of Cdh1 by Cdh1:APC/C0.91
    4M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for CDC27 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC27 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for CDC27
        Cell Cycle / Checkpoint Control
    Protein Stability

    5/7 GeneGo (Thomson Reuters) Pathways for CDC27 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for CDC27
        TGF-beta Receptor Signaling Pathway


    5/28        Reactome Pathways for CDC27 (see all 28)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Cell Cycle
    M Phase
    Phosphorylation of the APC/C
    Mitotic Spindle Checkpoint


    5         Kegg Pathways  (Kegg details for CDC27):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: CDC27_HUMAN, P30260
    Pathway: Protein modification; protein ubiquitination


    CDC27 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC27

    5/854 Interacting proteins for CDC27 (P302601, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 854)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC20Q128341, 2, 3EBI-994813,EBI-367462 MINT-8289337 MINT-7947479 I2D: score=5 
    BUB1BO605662, 3MINT-7945693 MINT-8289337 MINT-7947479 I2D: score=4 
    ANAPC1Q9H1A42, 3MINT-7945693 MINT-7947479 I2D: score=2 
    CDC16Q130422, 3MINT-7945693 MINT-7947479 I2D: score=11 
    CCNB1P146352, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007091metaphase/anaphase transition of mitotic cell cycle IMP7736578
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0008283cell proliferation TAS7736578
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--

    CDC27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC27

    Search CenterWatch for drugs/clinical trials and news about CDC27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC27 gene (2 alternative transcripts): 
    NM_001114091.1  NM_001256.3  

    Unigene Cluster for CDC27:

    Cell division cycle 27
    Hs.463295  [show with all ESTs]
    Unigene Representative Sequence: NM_001114091
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000066544(uc002ile.4 uc002ild.4 uc002ilf.4 uc010wkp.2 uc010wkq.1)
    ENST00000531206 ENST00000570740 ENST00000533415 ENST00000571643 ENST00000527547
    ENST00000526866 ENST00000573502 ENST00000525495 ENST00000574304 ENST00000575830
    ENST00000576484 ENST00000573550 ENST00000570818 ENST00000575483 ENST00000532893
    ENST00000528748 ENST00000532575

    miRNA
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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC27 (see all 81):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-15a hsa-miR-605 hsa-miR-208b hsa-miR-4325 hsa-miR-155*
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    Additional mRNA sequence: 

    AK296881.1 AK299342.1 BC011656.2 DQ786193.1 S78234.1 U00001.1 

    17 DOTS entries:

    DT.87079976  DT.87079975  DT.92438621  DT.100028974  DT.100774961  DT.100791415  DT.121006766  DT.95275736 
    DT.100642295  DT.87079977  DT.92036165  DT.95275731  DT.100791410  DT.92438634  DT.95129799  DT.95275743 
    DT.92438629 

    24/344 AceView cDNA sequences (see all 344):

    AA255818 T03706 AI018147 AI111176 AA767271 AI249763 BM930704 CB122172 
    BU740440 BQ434993 BF726492 BE045935 BE890688 BX494219 CD655725 BM981238 
    BQ432436 BU161195 BE327143 AA188804 AI827303 AW243733 BM473330 BU632234 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC27 expression in normal human tissues (normalized intensities)      CDC27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGTTGT
    CDC27 Expression
    About this image


    CDC27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See CDC27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC27

    SOURCE GeneReport for Unigene cluster: Hs.463295
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDC27: 
              Parkinson's Disease in human mouse rat
              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC27 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc271 , 5 cell division cycle 27 homolog (S. cerevisiae)5
    cell division cycle 271
    92.92(n)1
    97.09(a)1
      11 (67.79 cM)5
    2172321  NM_145436.21  NP_663411.21 
     1045027455 
    chicken
    (Gallus gallus)
    Aves CDC271 cell division cycle 27 homolog (S. cerevisiae) 86.27(n)
    95.75(a)
      419960  NM_001006331.1  NP_001006331.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC276
    Uncharacterized protein
    91(a)
    1 ↔ 1
    6(67234673-67257984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148642 Xenopus laevis transcribed sequence with moderate similarity more 76.9(n)    CA986047.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb54g062 Danio rerio mRNA similar to cell division cycle 27 more 75.06(n)    BC049466.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdc271 , 3 mitosis3
    CG8610-PA1
    37(a)3
    48.84(n)1
    45.4(a)1
      3 65F23
    387981  NM_139836.21  NP_648093.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mat-11 Protein MAT-1 43.23(n)
    31.32(a)
      172145  NM_001026543.3  NP_001021714.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC27(YBL084C)4
    CDC271
    Subunit of the Anaphase-Promoting Complex/Cyclosome more4
    Cdc27p1
    43.9(n)1
    31.27(a)1
      2(69445-67169)4
    8521941, 4  NP_009469.21  NP_009469.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HBT1 cell division cycle protein 27-B 44.57(n)
    35.51(a)
      816519  NM_179663.2  NP_849994.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06225001 hypothetical protein 44.66(n)
    37.8(a)
      4341553  NM_001064634.2  NP_001058099.2 


    ENSEMBL Gene Tree for CDC27 (if available)
    TreeFam Gene Tree for CDC27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC27 gene

    CDC27 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CDC27
    PGOHUM00000240958 PGOHUM00000261014


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1946 SNPs in CDC27 are shown (see all 1946)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358614
    A breast cancer sample4--see VAR_0358612 G A mis40--------
    rs751845081,2
    Cuntested145234403(+) TGAAAG/TTACAG 4 I L mis11Minor allele frequency- T:0.50NA 2
    rs749258481,2
    Cuntested145234404(+) GAAATG/TACAGC 4 V syn11Minor allele frequency- T:0.50NA 2
    rs2011878101,2
    Cuntested145234432(+) CTGAGG/TAATCT 4 Y S mis10--------
    rs783959971,2
    C,Funtested145234710(+) TGTAAA/CGATGT 4 S syn11Minor allele frequency- C:0.08EU 135
    VAR_0526134
    ----see VAR_0526132 S P mis40--------
    VAR_0144894
    ----see VAR_0144892 Y H mis40--------
    rs1416223901,2
    C--45194851(+) AAAAA-/TTTTCA 2 -- ds50010--------
    rs1852590371,2
    --45195186(+) TTGCTC/GTAGTT 2 -- ds50010--------
    rs765645841,2
    C,F--45195233(+) TGCCTT/CCTTAT 2 -- ds50011Minor allele frequency- C:0.06EA 120

    HapMap Linkage Disequilibrium report for CDC27 (45195069 - 45266788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/43 variations for CDC27 (see all 43):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715993CNV Deletion23290073
    dgv463e201CNV Deletion23290073
    esv2716009CNV Deletion23290073
    esv2715978CNV Deletion23290073
    dgv464e201CNV Deletion23290073
    dgv459e201CNV Deletion23290073
    dgv460e201CNV Deletion23290073
    esv4323CNV Deletion18987735
    esv2742082CNV Deletion23290073
    esv4896CNV Deletion18987735


    Human Gene Mutation Database (HGMD): CDC27
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116946    OMIM disorders: --

    8 diseases for CDC27:    About MalaCards
    herpes simplex    cytomegalovirus infection    retinoblastoma    parkinson's disease
    prostatitis    prostate cancer    breast cancer    neuronitis


    CDC27 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for CDC27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 32.2 1 15567442 (1)

    Genetic Association Database (GAD): CDC27
    Human Genome Epidemiology (HuGE) Navigator: CDC27 (1 document)

    Export disorders for CDC27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC27 gene, integrated from 9 sources (see all 159):
    (articles sorted by number of sources associating them with CDC27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. (PubMed id 8234252)1, 2, 3 Tugendreich S.... Hieter P.A. (1993)
    2. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner. (PubMed id 7756179)1, 2, 9 Chen P.L.... Lee W.H. (1995)
    3. Molecular basis for the association of microcephalin ( MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the an aphase-promoting complex. (PubMed id 22139841)1, 2 Singh N....Couch F.J. (2012)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    5. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    6. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (2003)
    9. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. (PubMed id 12429948)1, 9 Topper L.M....Gorbsky G.J. (2002)
    10. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PubMed id 9405394)1, 9 Ollendorff V. and Donoghue D.J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 996 HGNC: 1728 AceView: CDC27 Ensembl:ENSG00000004897 euGenes: HUgn996
    ECgene: CDC27 Kegg: 996 H-InvDB: CDC27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC27 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC27 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc27/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC27 gene:
    Search GeneIP for patents involving CDC27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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