Aliases for CDC26 Gene
External Ids for CDC26 Gene
Previous Symbols for CDC26 Gene
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDC26 Gene
CDC26 (Cell Division Cycle 26) is a Protein Coding gene. Diseases associated with CDC26 include brain cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic.
UniProtKB/Swiss-Prot for CDC26 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.