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Aliases for CDC26 Gene

Aliases for CDC26 Gene

  • Cell Division Cycle 26 2 3
  • APC12 3 4 6
  • CDC26 Subunit Of Anaphase Promoting Complex 2 3
  • Cell Division Cycle Protein 26 Homolog 3 4
  • Anaphase-Promoting Complex Subunit 12 3 4
  • C9orf17 3 4
  • ANAPC12 3 4
  • Cell Division Cycle 26 Homolog (S. Cerevisiae) 2
  • Anaphase-Promoting Complex Subunit CDC26 3
  • Anaphase Promoting Complex Subunit 12 2
  • Chromosome 9 Open Reading Frame 17 2
  • Cell Division Cycle 26 Homolog 3

External Ids for CDC26 Gene

Previous Symbols for CDC26 Gene

  • C9orf17

Summaries for CDC26 Gene

Entrez Gene Summary for CDC26 Gene

  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC26 Gene

CDC26 (Cell Division Cycle 26) is a Protein Coding gene. Diseases associated with CDC26 include brain cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CDC26 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC26 Gene

Genomics for CDC26 Gene

Genomic Location for CDC26 Gene

Start:
113,255,835 bp from pter
End:
113,275,589 bp from pter
Size:
19,755 bases
Orientation:
Minus strand

Genomic View for CDC26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC26 Gene

Regulatory Elements for CDC26 Gene

Proteins for CDC26 Gene

  • Protein details for CDC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHZ8-CDC26_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit CDC26
    Protein Accession:
    Q8NHZ8
    Secondary Accessions:

    Protein attributes for CDC26 Gene

    Size:
    85 amino acids
    Molecular mass:
    9777 Da
    Quaternary structure:
    • V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for CDC26 Gene

neXtProt entry for CDC26 Gene

Proteomics data for CDC26 Gene at MOPED

Post-translational modifications for CDC26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC26 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC26 Gene

Domains for CDC26 Gene

Gene Families for CDC26 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for CDC26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHZ8

UniProtKB/Swiss-Prot:

CDC26_HUMAN
Family:
  • Belongs to the CDC26 family.:
    • Q8NHZ8
genes like me logo Genes that share domains with CDC26: view

Function for CDC26 Gene

Molecular function for CDC26 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Ontology (GO) - Molecular Function for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with CDC26: view

Phenotypes for CDC26 Gene

GenomeRNAi human phenotypes for CDC26:
genes like me logo Genes that share phenotypes with CDC26: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDC26 Gene

Localization for CDC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC26 Gene COMPARTMENTS Subcellular localization image for CDC26 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 10922056
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC26: view

Pathways for CDC26 Gene

SuperPathways for CDC26 Gene

genes like me logo Genes that share pathways with CDC26: view

UniProtKB/Swiss-Prot Q8NHZ8-CDC26_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0030071 regulation of mitotic metaphase/anaphase transition --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with CDC26: view

Transcripts for CDC26 Gene

mRNA/cDNA for CDC26 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(168) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC26 Gene

Cell division cycle 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC26 Gene

No ASD Table

Relevant External Links for CDC26 Gene

GeneLoc Exon Structure for
CDC26
ECgene alternative splicing isoforms for
CDC26

Expression for CDC26 Gene

mRNA expression in normal human tissues for CDC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC26 Gene

SOURCE GeneReport for Unigene cluster for CDC26 Gene Hs.727648

genes like me logo Genes that share expressions with CDC26: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC26 Gene

Orthologs for CDC26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC26 35
  • 100 (n)
  • 100 (a)
CDC26 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC26 35
  • 91.76 (n)
  • 94.12 (a)
CDC26 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC26 35
  • 91.37 (n)
  • 94.12 (a)
CDC26 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc26 35
  • 86.27 (n)
  • 88.24 (a)
Cdc26 16
Cdc26 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC26 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc26 35
  • 87.45 (n)
  • 89.41 (a)
chicken
(Gallus gallus)
Aves CDC26 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC26 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15762 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9059 35
zebrafish
(Danio rerio)
Actinopterygii cdc26 35
  • 66.67 (n)
  • 65.88 (a)
cdc26 36
  • 63 (a)
OneToOne
Species with no ortholog for CDC26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC26 Gene

ENSEMBL:
Gene Tree for CDC26 (if available)
TreeFam:
Gene Tree for CDC26 (if available)

Paralogs for CDC26 Gene

No data available for Paralogs for CDC26 Gene

Variants for CDC26 Gene

Sequence variations from dbSNP and Humsavar for CDC26 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3087548 -- 113,266,894(-) GCACA(A/G)GACAC downstream-variant-500B
rs4979229 -- 113,272,196(+) ATGGA(C/T)CACTT intron-variant
rs9299214 -- 113,273,416(+) CTACA(A/G)AGTTA utr-variant-5-prime
rs9987440 -- 113,268,587(+) CCATT(C/T)TTCAC intron-variant
rs10117451 -- 113,273,610(+) GAAGG(G/T)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC26 Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294

Relevant External Links for CDC26 Gene

HapMap Linkage Disequilibrium report
CDC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC26 Gene

Disorders for CDC26 Gene

(1) MalaCards Diseases for CDC26 Gene

Search for CDC26 Gene in MalaCards »
genes like me logo Genes that share disorders with CDC26: view

No data available for UniProtKB/Swiss-Prot for CDC26 Gene

Publications for CDC26 Gene

  1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M. … Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  2. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4
  3. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. (PMID: 19668213) Wang J. … Schulman B.A. (Nat. Struct. Mol. Biol. 2009) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CDC26 Gene

Sources for CDC26 Gene

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