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Aliases for CDC26 Gene

Aliases for CDC26 Gene

  • Cell Division Cycle 26 2 3 5
  • CDC26 Subunit Of Anaphase Promoting Complex 2 3
  • Cell Division Cycle Protein 26 Homolog 3 4
  • Anaphase-Promoting Complex Subunit 12 3 4
  • C9orf17 3 4
  • ANAPC12 3 4
  • APC12 3 4
  • Cell Division Cycle 26 Homolog (S. Cerevisiae) 2
  • Anaphase-Promoting Complex Subunit CDC26 3
  • Anaphase Promoting Complex Subunit 12 2
  • Chromosome 9 Open Reading Frame 17 2
  • Cell Division Cycle 26 Homolog 3

External Ids for CDC26 Gene

Previous HGNC Symbols for CDC26 Gene

  • C9orf17

Previous GeneCards Identifiers for CDC26 Gene

  • GC09M106827
  • GC09M107761
  • GC09M109471
  • GC09M111405
  • GC09M113108
  • GC09M115069
  • GC09M116018
  • GC09M085636

Summaries for CDC26 Gene

Entrez Gene Summary for CDC26 Gene

  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC26 Gene

CDC26 (Cell Division Cycle 26) is a Protein Coding gene. Diseases associated with CDC26 include Pelvic Varices. Among its related pathways are HTLV-I infection and Immune System.

UniProtKB/Swiss-Prot for CDC26 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC26 Gene

Genomics for CDC26 Gene

Regulatory Elements for CDC26 Gene

Enhancers for CDC26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F113274 1.4 FANTOM5 ENCODE 28.9 +0.0 30 2.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 PRPF4 CDC26 WDR31 SLC31A2 RGS3 FKBP15 GC09P114223 PIR61584
GH09F113227 1.2 Ensembl ENCODE 30 +47.3 47302 1.2 HDAC1 PKNOX1 ATF1 MLX ARID4B DMAP1 RARA GATA2 CREM SP5 CDC26 PRPF4 SLC31A2 RNF183 SLC31A1 PIR39900
GH09F113218 1.5 FANTOM5 ENCODE 20.9 +54.5 54514 5.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 PRPF4 CDC26 RPL32P22 WDR31 SLC31A2 SNX30 FKBP15 SLC46A2 RGS3 PIR31842
GH09F113232 1.3 FANTOM5 Ensembl ENCODE 20.2 +42.3 42289 2.2 SOX13 KLF1 BMI1 CEBPG ZNF791 ZNF366 FOS MAFK GATAD2A SOX5 PRPF4 CDC26 SLC31A2 BSPRY SLC46A2 SNX30 FKBP15 RGS3 SLC31A1 PIR39900
GH09F113215 1 Ensembl ENCODE 21.1 +60.1 60089 0.6 CTCF PKNOX1 BACH1 ZNF316 NFE2 FOSL2 FOS MAFK NFE2L2 NFIA PRPF4 CDC26 WDR31 FKBP15 PIR31842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC26 on UCSC Golden Path with GeneCards custom track

Promoters for CDC26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001312016 -11 2401 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for CDC26 Gene

Chromosome:
9
Start:
113,255,835 bp from pter
End:
113,275,589 bp from pter
Size:
19,755 bases
Orientation:
Minus strand

Genomic View for CDC26 Gene

Genes around CDC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC26 Gene

Proteins for CDC26 Gene

  • Protein details for CDC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHZ8-CDC26_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit CDC26
    Protein Accession:
    Q8NHZ8

    Protein attributes for CDC26 Gene

    Size:
    85 amino acids
    Molecular mass:
    9777 Da
    Quaternary structure:
    • V-shaped homodimer. Interacts with CDC16. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for CDC26 Gene

neXtProt entry for CDC26 Gene

Post-translational modifications for CDC26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC26 Gene

No data available for DME Specific Peptides for CDC26 Gene

Domains & Families for CDC26 Gene

Gene Families for CDC26 Gene

Protein Domains for CDC26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHZ8

UniProtKB/Swiss-Prot:

CDC26_HUMAN :
  • Belongs to the CDC26 family.
Family:
  • Belongs to the CDC26 family.
genes like me logo Genes that share domains with CDC26: view

Function for CDC26 Gene

Molecular function for CDC26 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Ontology (GO) - Molecular Function for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with CDC26: view
genes like me logo Genes that share phenotypes with CDC26: view

Animal Models for CDC26 Gene

MGI Knock Outs for CDC26:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CDC26 Gene

Localization for CDC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC26 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 10922056
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC26: view

Pathways & Interactions for CDC26 Gene

SuperPathways for CDC26 Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence
genes like me logo Genes that share pathways with CDC26: view

UniProtKB/Swiss-Prot Q8NHZ8-CDC26_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CDC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030071 regulation of mitotic metaphase/anaphase transition IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
genes like me logo Genes that share ontologies with CDC26: view

No data available for SIGNOR curated interactions for CDC26 Gene

Transcripts for CDC26 Gene

mRNA/cDNA for CDC26 Gene

Unigene Clusters for CDC26 Gene

Cell division cycle 26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC26 Gene

No ASD Table

Relevant External Links for CDC26 Gene

GeneLoc Exon Structure for
CDC26
ECgene alternative splicing isoforms for
CDC26

Expression for CDC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDC26 Gene

This gene is overexpressed in Lung (29.3), Peripheral blood mononuclear cells (9.1), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC26 Gene



Protein tissue co-expression partners for CDC26 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDC26 Gene:

CDC26

SOURCE GeneReport for Unigene cluster for CDC26 Gene:

Hs.727648
genes like me logo Genes that share expression patterns with CDC26: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC26 Gene

Orthologs for CDC26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC26 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CDC26 34 35
  • 91.76 (n)
dog
(Canis familiaris)
Mammalia CDC26 34 35
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC26 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc26 34
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Cdc26 34 16 35
  • 86.27 (n)
chicken
(Gallus gallus)
Aves CDC26 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC26 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15762 34
zebrafish
(Danio rerio)
Actinopterygii cdc26 34 35
  • 66.67 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9059 34
Species where no ortholog for CDC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC26 Gene

ENSEMBL:
Gene Tree for CDC26 (if available)
TreeFam:
Gene Tree for CDC26 (if available)

Paralogs for CDC26 Gene

No data available for Paralogs for CDC26 Gene

Variants for CDC26 Gene

Sequence variations from dbSNP and Humsavar for CDC26 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs541873609 Pathogenic 113,275,630(+) CGTCT(-/TGTCAGTGACGCACTTCC)TGTCA upstream-variant-2KB
rs10116039 -- 113,275,900(+) CTCAG(C/T)GGTGT intron-variant, upstream-variant-2KB
rs10117451 -- 113,273,610(+) GAAGG(G/T)CAGGC intron-variant
rs10120404 -- 113,273,845(+) AAAAA(A/G)AGGCT intron-variant, upstream-variant-2KB
rs10122180 -- 113,275,898(+) GACTC(A/G)GCGGT intron-variant, upstream-variant-2KB

Variation tolerance for CDC26 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDC26 Gene

Disorders for CDC26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CDC26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDC26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC26
genes like me logo Genes that share disorders with CDC26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC26 Gene

Publications for CDC26 Gene

  1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M. … Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 64
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
  3. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. (PMID: 19668213) Wang J. … Schulman B.A. (Nat. Struct. Mol. Biol. 2009) 3 4 64
  4. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4 64

Products for CDC26 Gene

Sources for CDC26 Gene

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