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CDC26 Gene

protein-coding   GIFtS: 50
GCID: GC09M116018

Cell Division Cycle 26

(Previous names: chromosome 9 open reading frame 17, cell division cycle...)
(Previous symbol: C9orf17)
  See CDC26-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cell Division Cycle 261 2     ANAPC122 3
C9orf171 2 3     Anaphase Promoting Complex Subunit 121
APC122 3 5     Cell Division Cycle 26 Homolog (S. Cerevisiae)1
CDC26 Subunit Of Anaphase Promoting Complex1 2     Chromosome 9 Open Reading Frame 171
Anaphase-Promoting Complex Subunit 122 3     Anaphase-Promoting Complex Subunit CDC262
Cell Division Cycle Protein 26 Homolog2 3     Cell Division Cycle 26 Homolog2

External Ids:    HGNC: 178391   Entrez Gene: 2461842   Ensembl: ENSG000001763867   OMIM: 6145335   UniProtKB: Q8NHZ83   
ORGUL members:         

Export aliases for CDC26 gene to outside databases

Previous GC identifers: GC09M106827 GC09M107761 GC09M109471 GC09M111405 GC09M113108 GC09M115069 GC09M085636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC26 Gene:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle
anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell
cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of
various proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC26 Gene:
CDC26 (cell division cycle 26) is a protein-coding gene. Diseases associated with CDC26 include brain cancer.

UniProtKB/Swiss-Prot: CDC26_HUMAN, Q8NHZ8
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDC26 gene promoter:
         RP58   Elk-1   NF-E2 p45   E47   NF-AT   NF-AT4   NF-AT2   NF-AT3   Hand1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC26 promoter sequence
   Search Chromatin IP Primers for CDC26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

CDC26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC26 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M116018:  view genomic region     (about GC identifiers)

Start:
116,018,115 bp from pter      End:
116,037,869 bp from pter
Size:
19,755 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDC26_HUMAN, Q8NHZ8 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit CDC26  
Size: 85 amino acids; 9777 Da
Subunit: The APC/C is composed of at least 12 subunits
1 PDB 3D structure from and Proteopedia for CDC26:
3HYM (3D)    

Explore the universe of human proteins at neXtProt for CDC26: NX_Q8NHZ8

Explore proteomics data for CDC26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_644815.1  
    ENSEMBL proteins: 
     ENSP00000363322  
    Reactome Protein details: Q8NHZ8

    CDC26 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    1 InterPro protein domain:
     IPR018860 APC_suCDC26

    Graphical View of Domain Structure for InterPro Entry Q8NHZ8

    ProtoNet protein and cluster: Q8NHZ8

    UniProtKB/Swiss-Prot: CDC26_HUMAN, Q8NHZ8
    Similarity: Belongs to the CDC26 family


    Find genes that share domains with CDC26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC26_HUMAN, Q8NHZ8
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CDC26           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDC26:
     Increased cell death in HCT116  Large cells 

         1 MGI phenotypic allele for Cdc26 (no phenotypes)

    Find genes that share phenotypes with CDC26           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC26
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC26

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CDC26:
    hsa-miR-298 hsa-miR-216a hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidCDC26 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC26

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC26_HUMAN, Q8NHZ8: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA10922056
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDC26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC26 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with CDC26           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for CDC26 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation


    Selected Reactome Pathways for CDC26 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for CDC26):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: CDC26_HUMAN, Q8NHZ8
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC26
    Interactions:

        Search GeneGlobe Interaction Network for CDC26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC26 (Q8NHZ81, 3 ENSP000003633224) via UniProtKB, MINT, STRING, and/or I2D (see all 99)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC16Q130421, 3, ENSP000003485544EBI-2555941,EBI-994830 I2D: score=1 STRING: ENSP00000348554
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    ANAPC13Q9BS183, ENSP000003469874I2D: score=1 STRING: ENSP00000346987
    ANAPC16Q96DE53, ENSP000002993814I2D: score=1 STRING: ENSP00000299381
    ANAPC5Q9UJX43, ENSP000002618194I2D: score=1 STRING: ENSP00000261819
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0030071regulation of mitotic metaphase/anaphase transition ----
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--

    Find genes that share ontologies with CDC26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC26



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC26 gene: 
    NM_139286.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490408 ENST00000374206(uc004bgw.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CDC26:
    hsa-miR-298 hsa-miR-216a hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidCDC26 3' UTR sequence
    Inhib. RNA
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    GenScript Custom all cDNA clones Services for CDC26
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC26
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CDC26

    Selected AceView cDNA sequences (see all 168):

    BC042534 BU752775 BM748519 BM142351 AA953969 BM675097 NM_139286 BU620494 
    CD370296 BU620518 AI057575 AA608646 CA440644 AI745226 CA446805 AI886300 
    BM905851 N50732 AI673394 BM673455 N93170 AI802361 CK905419 BM849786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTACTGA
    CDC26 Expression
    About this image


    CDC26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDC26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC26 Protein Expression
        Custom PCR Arrays for CDC26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDC26 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc261 , 5 cell division cycle 261, 5 86.27(n)1
    88.24(a)1
      4 (33.12 cM)5
    664401  NM_139291.31  NP_647452.11 
     623836545 
    chicken
    (Gallus gallus)
    Aves CDC266
    cell division cycle 26
    63(a)
    1 ↔ 1
    17(1475849-1476656)
    lizard
    (Anolis carolinensis)
    Reptilia CDC266
    cell division cycle 26
    81(a)
    1 ↔ 1
    GL344086.1(32394-33694)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.157622 Transcribed sequences 76.06(n)    137730046 
    zebrafish
    (Danio rerio)
    Actinopterygii BM140791.12   -- 73.52(n)    BM140791.1 


    ENSEMBL Gene Tree for CDC26 (if available)
    TreeFam Gene Tree for CDC26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDC26 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020653181,2
    --116028792(+) AAAAA-/TTTTTT 1 -- ds50010--------
    rs1919787481,2
    --116028796(+) AATTTA/TTAAAA 1 -- ds50010--------
    rs412802311,2
    C,F--116028797(+) ATTTTT/AAAAAA 1 -- ds50012Minor allele frequency- A:0.13WA EA 238
    rs412767741,2
    --116028798(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs1391901951,2
    C--116028805(+) AAAAA-/ATTTTTT 1 -- ds50010--------
    rs597552611,2
    --116028806(+) AAAAAA/TTTTTT 1 -- ds50010--------
    rs101250301,2
    C,F,A--116028823(+) GCCCAG/AAACAA 1 -- ds50016Minor allele frequency- A:0.28NA WA CSA 245
    rs1864578621,2
    --116028834(+) TAGGGC/TATGAT 1 -- ds50010--------
    rs1397127621,2
    --116028855(+) CCTCCA/GAGCTG 1 -- ds50010--------
    rs101250321,2
    C,F--116028857(+) TCCGAG/ACTGCC 1 -- ds50015Minor allele frequency- A:0.33NA WA CSA 126

    HapMap Linkage Disequilibrium report for CDC26 (116018115 - 116037869 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDC26:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893744CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC26
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614533    OMIM disorders: --

    1 disease for CDC26:    
    About MalaCards
    brain cancer


    Find genes that share disorders with CDC26           About GenesLikeMe


    Export disorders for CDC26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC26 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CDC26)
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    1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PubMed id 10922056)1, 2, 3 Gmachl M.... Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. (PubMed id 8895471)1, 3 Zachariae W....Nasmyth K. (Science 1996)
    7. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. (PubMed id 23007861)1 Uzunova K....Peters J.M. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 246184 HGNC: 17839 AceView: CDC26 Ensembl:ENSG00000176386 euGenes: HUgn246184
    ECgene: CDC26 Kegg: 246184 H-InvDB: CDC26

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC26 gene:
    Search GeneIP for patents involving CDC26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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