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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC25C Gene

protein-coding GIFtS: 71
GCID: GC05M137620

cell division cycle 25C

(Previous names: cell division cycle 25C, cell division cycle 25 homolog...)
(Previous symbol: CDC25)

Explore 65 diseases affiliated with
CDC25C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 25C¹ ²		Cell Division Cycle 25 Homolog C (S. Pombe)¹
CDC25¹ ²		M-Phase Inducer Phosphatase 3²
PPP1R60¹ ²		Mitosis Inducer CDC25²
Dual Specificity Phosphatase Cdc25C² ³		Phosphotyrosine Phosphatase²
EC 3.1.3.48³ ⁸		Protein Phosphatase 1, Regulatory Subunit 60²
Cell Division Cycle 25 Homolog C (S. Cerevisiae)¹

External Ids:	HGNC: 1727¹	Entrez Gene: 995²	Ensembl: ENSG00000158402⁷	OMIM: 157680⁵	UniProtKB: P30307³

Export aliases for CDC25C gene to outside databases

Previous GC identifers: GC05M137495 GC05M138296 GC05M137651 GC05M137697 GC05M137648 GC05M132811

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC25C:

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded

protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin

B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple

alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of

them is not known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307

Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for

progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly

dephosphorylates CDK1 and activates its kinase activity

summary for CDC25C:

Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25

activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA

damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,

interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated

and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further

phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is

also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.

Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.

Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit

mitosis.

Gene Wiki entry for CDC25C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC25C gene promoter:
ATF-2 STAT3 NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDC25C promoter sequence

Search SABiosciences Chromatin IP Primers for CDC25C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC25C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31

CDC25C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25C gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M137620: view genomic region (about GC identifiers)

Start:	137,620,954 bp from pter	End:	137,674,044 bp from pter
Size:	53,091 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307 (See protein sequence)

Recommended Name: M-phase inducer phosphatase 3

Size: 473 amino acids; 53365 Da

Subunit: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3

proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1

Subcellular location: Nucleus

Developmental stage: Expressed predominantly in G2 phase

2 PDB 3D structures from and Proteopedia for CDC25C:

3BZI (3D)

3OP3 (3D)

Secondary accessions: D3DQB8 Q96PL3 Q9H168 Q9H2E8 Q9H2E9 Q9H2F1

Alternative splicing: 5 isoforms: P30307-1 P30307-2 P30307-5 P30307-3 P30307-4 (Contains a phosphoserine at position 61)

Explore the universe of human proteins at neXtProt for CDC25C: NX_P30307

Post-translational modifications:

Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and

inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase

activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site.

Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by

PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214

occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than

those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30307

4/9 DME Specific Peptides for CDC25C (P30307) (see all 9)

PQSYCPM

FHCEFSS

YPELYIL

CLDLSNL

CDC25C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001781.2 NP_073720.1

ENSEMBL proteins:

ENSP00000321656 ENSP00000392631 ENSP00000424795 ENSP00000425470 ENSP00000423525

ENSP00000427251 ENSP00000427105 ENSP00000348898 ENSP00000349821 ENSP00000345205

Reactome Protein details: P30307
Human Recombinant Protein Products:

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	Enzo Life Sciences proteins for CDC25C
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CDC25C OriGene Custom Protein Services for CDC25C
	GenScript Custom Purified and Recombinant Proteins Services for CDC25C
	Novus Biologicals CDC25C Proteins Novus Biologicals CDC25C Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC25C

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	14968113
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

CDC25C for ontologies About GeneDecksing

CDC25C Antibody Products:

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	ThermoFisher Antibody for CDC25C

Assay Products for CDC25C:

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	GenScript Custom Assay Services for CDC25C
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC25C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC25C for domains About GeneDecksing

2 InterPro domains/families:

IPR001763 Rhodanese-like_dom

IPR000751 MPI_Phosphatase

Graphical View of Domain Structure for InterPro Entry P30307

ProtoNet protein and cluster: P30307

2 Blocks protein families:

IPB000751 M-phase inducer phosphatase signature

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307

Similarity: Belongs to the MPI phosphatase family

Similarity: Contains 1 rhodanese domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307

Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for

progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly

dephosphorylates CDK1 and activates its kinase activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Genatlas biochemistry entry for CDC25C:

cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF)

component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

miRNA Products:		miRTarBase miRNAs that target CDC25C: hsa-mir-34a (MIRT000751)

		OriGene 3'-UTR Clone (see all 2): CDC25C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC25C
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC25C:
		hsa-miR-767-3p hsa-miR-1253
		SwitchGear 3'UTR luciferase reporter plasmid: CDC25C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC25C (see all 7) OriGene shRNA RFP: CDC25C OriGene siRNA: CDC25C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC25C

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CDC25C

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25C (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25C (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CDC25C (NM_022809)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC25C
		Search LifeMap BioReagents cell lines for CDC25C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25C

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	NAS	11078813
GO:0005515	protein binding	IPI	17349584
GO:0019901	protein kinase binding	IPI	14968113
GO:0050699	WW domain binding	IPI	10037602

CDC25C for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CDC25C:

Decreased focal adhesion (FA)

Downregulation of NF-kappaB pa

Animal Models:
Mouse knock-out Cdc25c^tm1Hpw for CDC25C
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdc25c):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	mortality/aging
normal

CDC25C for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Role of 14-3-3 proteins in cell cycle regulation

	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation	1.00			14-3-3 and Cell Cycle Regulation	0.45
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation	1.00

Cell cycle_Cell cycle (generic schema)

Cell cycle_Cell cycle (generic schema)

1.00

Cell cycle Cell cycle (generic schema)

1.00

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

G2/M DNA damage checkpoint

G2/M DNA damage checkpoint

1.00

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

0.56

Cyclin B2 mediated events

Cyclin B2 mediated events

1.00

Cyclin A/B1 associated events during G2/M transition

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CDC25C

	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	Cell cycle Cell cycle (generic schema)

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC25C (see all 7)

	14-3-3 and Cell Cycle Regulation
	ATM Pathway
	G2-M Phase Transition
	Molecular Mechanisms of Cancer
	p38 Signaling

2 Cell Signaling Technology (CST) Pathways for CDC25C

	Phosphatases
	Cell Cycle / Checkpoint Control

2 GeneGo (Thomson Reuters) Pathways for CDC25C

	Cell cycle Cell cycle (generic schema)
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation

5/8 BioSystems Pathways for CDC25C (see all 8)

	DNA damage response
	Cell cycle
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Wnt Signaling Pathway NetPath

5/12 Reactome Pathways for CDC25C (see all 12)

	Activation of ATR in response to replication stress
	Cell Cycle
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
	Cyclin B2 mediated events
	G2/M Transition

3 Kegg Pathways (Kegg details for CDC25C):

	Cell cycle
	Oocyte meiosis
	Progesterone-mediated oocyte maturation

CDC25C for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC25C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for CDC25C (P30307^{1, 2, 3} ENSP00000321656⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAE	P62258²^,³, ENSP00000264335⁴	MINT-8008886 I2D: score=2 STRING: ENSP00000264335
CDK1	P06493¹^,³	EBI-974439,EBI-444308 I2D: score=5
PLK1	P53350²^,³, ENSP00000300093⁴	MINT-16690 MINT-50542 MINT-16691 I2D: score=5 STRING: ENSP00000300093
CHEK1	O14757¹^,³, ENSP00000278916⁴	EBI-974439,EBI-974488 I2D: score=3 STRING: ENSP00000278916
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3294433 I2D: score=3 STRING: ENSP00000309503

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	11139144
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000087	M phase of mitotic cell cycle	NAS	--
GO:0000278	mitotic cell cycle	TAS	--

CDC25C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC25C for compounds About GeneDecksing

EMD Millipore small molecules for CDC25C:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CDC25C available from Tocris Bioscience About this table

Compound	Action	CAS #
NSC 95397	Selective Cdc25 dual specificity phosphatase inhibitor	[93718-83-3]
NSC 663284	Potent, selective Cdc25 phosphatase inhibitor	[383907-43-5]

2 HMDB Compounds for CDC25C About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/81 Novoseek chemical compound relationships for CDC25C gene (see all 81) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphotyrosine	94.8	322	8626400 (4), 1360008 (4), 11356684 (3), 12149261 (3) (see all 99)
vanadate	75.9	24	10569804 (2), 8626400 (1), 9275062 (1), 10978247 (1) (see all 23)
sodium orthovanadate	75.5	17	7829501 (2), 1645256 (1), 7498427 (1), 10978247 (1) (see all 16)
tyrosine	75.3	104	1913817 (6), 1655274 (3), 10773618 (2), 15827333 (2) (see all 78)
3-tyrosine	75.1	2	12175337 (1), 12763027 (1)
phenylarsine oxide	71.9	16	12761345 (2), 7997241 (2), 7589239 (1), 8617880 (1) (see all 11)
bis(maltolato)oxovanadium(iv)	71.4	1	8910360 (1)
phosphothreonine	70.5	3	15140384 (1), 9182566 (1), 11013245 (1)
bpv(phen)	69.7	4	12536146 (1), 12375165 (1), 12759336 (1)
phosphoserine	65.6	4	15140384 (1), 9182566 (1), 16916641 (1), 11090625 (1)

Search CenterWatch for drugs/clinical trials and news about CDC25C / MPIP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC25C gene (2 alternative transcripts):

NM_001790.3 NM_022809.2

Unigene Cluster for CDC25C:

Cell division cycle 25 homolog C (S. pombe)

Hs.656 [show with all ESTs]

Unigene Representative Sequence: NM_001790

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000323760(uc003lcp.1 uc003lcr.1) ENST00000415130 ENST00000513970(uc011cyp.1 uc003lcs.1)

ENST00000514555 ENST00000514017 ENST00000503022(uc003lct.1) ENST00000510119

ENST00000504831 ENST00000356505(uc010jet.1) ENST00000357274(uc003lcu.1)

ENST00000348983(uc003lcq.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC25C

Additional cDNA sequence:

AF086323.1 AF277723.1 AF277724.1 AF277725.1 AF277726.1 AF312681.1 AJ304504.1 AK097710.1

AK301828.1 BC019089.2 M34065.1

6 DOTS entries:

DT.445068 DT.95078853 DT.92428592 DT.100762094 DT.202903 DT.100788753

24/103 AceView cDNA sequences (see all 103):

BC019089 CB110938 AA970118 CR595730 BM722159 AL525498 BU527942 CB159024

CB161064 AU103727 AU098899 AJ304504 AW293748 AF312681 CR605066 AF277726

CR618165 AW779598 CN482564 AW401554 CR590865 AF277725 AK097710 BU507476

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b
SP1:
SP2:
SP3:									-				-		-
SP4:									-				-		-

ECgene alternative splicing isoforms for CDC25C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC25C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTCTCACA

About this image
See CDC25C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC25C

SOURCE GeneReport for Unigene cluster: Hs.656

SABiosciences Expression via Pathway-Focused PCR Arrays including CDC25C:

Cell Cycle in human mouse rat

DNA Damage Signaling Pathway in human mouse rat

p53 Signaling Pathway in human mouse rat

Cellular Senescence in human mouse rat

Protein Phosphatases in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CDC25C gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdc25c^{1 , 5}	cell division cycle 25 homolog C (S. pombe)⁵ cell division cycle 25C¹	79.65(n)¹ 71.02(a)¹		18 (18.71 cM)⁵ 12532¹ NM_009860.2¹ NP_033990.2¹ 34732997⁵
lizard (Anolis carolinensis)	Reptilia	CDC25C⁶	--	48(a)	1 ↔ 1	2(146478246-146501163)
African clawed frog (Xenopus laevis)	Amphibia	xcdc25-3²	cdc25 protein	75.06(n)		M94264.1
zebrafish (Danio rerio)	Actinopterygii	cdc25d⁶	cell division cycle 25 homolog d	24(a)	1 ↔ 1	1(55260650-55274851)
fruit fly (Drosophila melanogaster)	Insecta	stg³	protein amino acid dephosphorylation protein tyrosine phosphatase less	46(a) (best of 2)		3 99A5 --
worm (Caenorhabditis elegans)	Secernentea	cdc-25.4⁶ cdc-25.3⁶ (see all 4)	M-phase inducer phosphatase cdc-25.3 (see all 4)	23(a) 22(a) (see all 4)	possible ortholog possible ortholog (see all 4)	II(10188251-10189346) III(8916339-8917853)

ENSEMBL Gene Tree for CDC25C (if available)
TreeFam Gene Tree for CDC25C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CDC25C gene

CDC25B² CDC25A²

3 SIMAP similar genes for CDC25C using alignment to 5 protein entries: MPIP3_HUMAN (see all proteins):

CDC25B DKFZp686G14213 CDC25A

CDC25C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138304050^1,2		--	137620550(+)	`GTTGTC/TTGGTA`	2	--	ds500¹		0	--	--	--	--
rs192725671^1,2		--	137620606(+)	`GGTGGC/GACGAT`	2	--	ds500¹		0	--	--	--	--
rs184799931^1,2		--	137620675(+)	`AGCTGG/TGACTA`	2	--	ds500¹		0	--	--	--	--
rs11568010^1,2	C,	--	137620689(-)	`GTGGCG/ATGTGC`	2	--	ds500¹		1		NS	170
rs11242418^1,2	C,F,H,	--	137620690(-)	`ggtggC/Tgtgtg`	2	--	ds500¹		1		NS	170
rs11568009^1,2	C,F,	--	137620789(-)	`TTTGGG/AAGGCC`	2	--	ds500¹		1		NS	170
rs113581774^1,2	C,	--	137621011(+)	`GAAACT/AAAGAA`	2	--	ut3¹		1		NA	2
rs150884142^1,2		--	137621045(+)	`GACAAA/CGCTCT`	2	--	ut3¹		0	--	--	--	--
rs138254117^1,2		--	137621079(+)	`AAAGAG/TTTGGC`	2	--	ut3¹		0	--	--	--	--
rs3813320^1,2	C,F,H,	--	137621257(+)	`TGGTAG/ACCTGT`	2	--	ut3¹		7		EA NS NA	2080

HapMap Linkage Disequilibrium report for CDC25C (137620954 - 137674044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC25C: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC25C for disorders           About GeneDecksing

OMIM gene information: 157680    OMIM disorders: --

20/65 diseases for CDC25C (see all 65):    About MalaCards

non-hodgkin lymphoma ataxia telangiectasia burkitt's lymphoma oral squamous cell carcinoma

cystic fibrosis squamous cell carcinoma hodgkin's lymphoma adult t-cell leukemia

noonan syndrome chronic lymphocytic leukemia chronic myeloid leukemia herpes simplex

plague lymphocytic leukemia myeloid leukemia insulin resistance

malignant glioma endometrial cancer neuroendocrine tumor carcinoma

1 disease from the University of Copenhagen DISEASES database for CDC25C:

Cancer

10/28 Novoseek disease relationships for CDC25C gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	51.3	2	17172433 (1), 18408079 (1)
cancer	43.9	30	17568790 (3), 16179969 (1), 20166845 (1), 19212959 (1) (see all 19)
tumors	35.5	28	19074854 (3), 10022129 (2), 11149596 (2), 11972334 (1) (see all 22)
colon carcinoma	29.3	1	11401329 (1)
prostate cancer	29.3	13	16000564 (5), 15961392 (1), 19885599 (1), 20143254 (1) (see all 5)
ovarian cancer	16.1	5	11356684 (3), 11205229 (2)
breast cancer	12	2	18191419 (1), 20514472 (1)
endometrial cancer	10.7	1	11356684 (1)
prostate carcinoma	8.51	1	17936851 (1)
glioblastoma	6.72	1	17525741 (1)

Human Genome Epidemiology (HuGE) Navigator: CDC25C (11 documents)

Export disorders for CDC25C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDC25C gene, integrated from 9 sources (see all 665):
(articles sorted by number of sources associating them with CDC25C)

Utopia: connect your pdf to the dynamic
world of online information

An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. (PubMed id 11078813)^{1, 2, 9} Bureik M....Wagner P. (2000)
Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. (PubMed id 8119945)^{1, 2, 9} Strausfeld U....Lamb N.J. (1994)
Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. (PubMed id 14968113)^{1, 2, 9} Bahassi e.l. .M....Stambrook P.J. (2004)
The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. (PubMed id 14972559)^{1, 2, 9} Goh W.C.... Emerman M. (2004)
The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. (PubMed id 11202906)^{1, 2, 9} Roshak A.K....Marshall L.A. (2000)
Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. (PubMed id 11304565)^{1, 2, 9} Hernandez S.... Campo E. (2001)
Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PubMed id 11139144)^{1, 2, 9} Wegener S.... Schaller H.C. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. (PubMed id 15150265)^{1, 2} Lu R.... Nakanishi M. (2004)
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. (PubMed id 12595692)^{1, 2} Elia A.E....Yaffe M.B. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 995	HGNC: 1727	AceView: CDC25C	Ensembl:ENSG00000158402	euGenes: HUgn995
ECgene: CDC25C	Kegg: 995	H-InvDB: CDC25C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDC25C	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDC25C	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc25c/

Intellectual Property for CDC25C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDC25C gene:
Search GeneIP for patents involving CDC25C

GeneCards and IP:
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cell division cycle 25C

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CDC25C Gene

cell division cycle 25C

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