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CDC25C Gene

protein-coding   GIFtS: 73
GCID: GC05M137620

Cell Division Cycle 25C

(Previous names: cell division cycle 25C, cell division cycle 25 homolog...)
(Previous symbol: CDC25)
  See CDC25C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 25C1 2     Regulatory Subunit 601
CDC251 2     PPP1R602
Dual Specificity Phosphatase Cdc25C2 3     M-Phase Inducer Phosphatase 32
EC 3.1.3.483 8     Mitosis Inducer CDC252
Cell Division Cycle 25 Homolog C (S. Cerevisiae)1     Phosphotyrosine Phosphatase2
Cell Division Cycle 25 Homolog C (S. Pombe)1     Protein Phosphatase 1, Regulatory Subunit 602
Protein Phosphatase 11     

External Ids:    HGNC: 17271   Entrez Gene: 9952   Ensembl: ENSG000001584027   OMIM: 1576805   UniProtKB: P303073   

Export aliases for CDC25C gene to outside databases

Previous GC identifers: GC05M137495 GC05M138296 GC05M137651 GC05M137697 GC05M137648 GC05M132811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC25C Gene:
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The
encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs
dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress
p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described,
however, the full-length nature of many of them is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC25C Gene:
CDC25C (cell division cycle 25C) is a protein-coding gene. Diseases associated with CDC25C include hyperapobetalipoproteinemia, and plague. GO annotations related to this gene include WW domain binding and protein kinase binding. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307
Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for
progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase.
Directly dephosphorylates CDK1 and activates its kinase activity

summary for CDC25C Gene:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC25C gene promoter:
         ATF-2   STAT3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CDC25C promoter sequence
   Search Chromatin IP Primers for CDC25C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC25C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

CDC25C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25C gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137620:  view genomic region     (about GC identifiers)

Start:
137,620,954 bp from pter      End:
137,674,044 bp from pter
Size:
53,091 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 3  
Size: 473 amino acids; 53365 Da
Subunit: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and
14-3-3 proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1
Developmental stage: Expressed predominantly in G2 phase
2 PDB 3D structures from and Proteopedia for CDC25C:
3BZI (3D)        3OP3 (3D)    
Secondary accessions: D3DQB8 Q96PL3 Q9H168 Q9H2E8 Q9H2E9 Q9H2F1
Alternative splicing: 5 isoforms:  P30307-1   P30307-2   P30307-5   P30307-3   P30307-4   (Contains a phosphoserine at position 61)

Explore the universe of human proteins at neXtProt for CDC25C: NX_P30307

Explore proteomics data for CDC25C at MOPED

Post-translational modifications: 

  • Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and
    inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase
    activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation
    site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such
    phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130,
    Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation
    levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDC25C (P30307) (see all 9)
     PQSYCPM  FHCEFSS  YPELYIL  CLDLSNL 


    See CDC25C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001274511.1  NP_001274512.1  NP_001781.2  NP_073720.1  

    ENSEMBL proteins: 
     ENSP00000321656   ENSP00000392631   ENSP00000424795   ENSP00000425470   ENSP00000423525  
     ENSP00000427251   ENSP00000427105   ENSP00000348898   ENSP00000349821   ENSP00000345205  
    Reactome Protein details: P30307

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    Novus Biologicals CDC25C Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC25C

     
    Search eBioscience for Proteins for CDC25C 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    PTP3: Protein tyrosine phosphatases / Class III Cys-based PTPs

    2 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30307

    ProtoNet protein and cluster: P30307

    2 Blocks protein domains:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain


    Find genes that share domains with CDC25C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPIP3_HUMAN, P30307
    Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for
    progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase.
    Directly dephosphorylates CDK1 and activates its kinase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for CDC25C:
    cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF)
    component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity NAS11078813
    GO:0005515protein binding IPI11836499
    GO:0019901protein kinase binding IPI14968113
    GO:0050699WW domain binding IPI10037602
         
    Find genes that share ontologies with CDC25C           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDC25C:
     Decreased focal adhesion (FA)   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdc25c):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  mortality/aging 
     normal 

    Find genes that share phenotypes with CDC25C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdc25ctm1Hpw for CDC25C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC25C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC25C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC25C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC25C

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC25C:
    hsa-mir-221-3p (MIRT046939), hsa-mir-34a-5p (MIRT000751)

    Block miRNA regulation of human, mouse, rat CDC25C using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CDC25C:
    hsa-miR-767-3p hsa-miR-1253
    SwitchGear 3'UTR luciferase reporter plasmidCDC25C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC25C
    Predesigned siRNA for gene silencing in human, mouse, rat CDC25C

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDC25C (NM_022809)
    Sino Biological Human cDNA Clone for CDC25C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25C
    Addgene plasmids for CDC25C 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPIP3_HUMAN, P30307: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA14968113
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDC25C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC25C About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3G2/M Checkpoints
    G2/M Checkpoints0.84
    Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex0.00
    Activation of ATR in response to replication stress0.84
    G2/M DNA damage checkpoint0.00
    4Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CDC25C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC25C (see all 7)
        14-3-3 and Cell Cycle Regulation
    ATM Pathway
    G2-M Phase Transition
    Molecular Mechanisms of Cancer
    p38 Signaling

    2 Cell Signaling Technology (CST) Pathways for CDC25C
        Phosphatases
    Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDC25C
        Cell cycle Cell cycle (generic schema)
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for CDC25C (see all 7)
        Cell cycle
    DNA damage response
    Wnt Signaling Pathway NetPath
    Monoamine Transport
    Integrated Pancreatic Cancer Pathway


    5 Reactome Pathways for CDC25C
        Cyclin B2 mediated events
    Activation of ATR in response to replication stress
    Polo-like kinase mediated events
    Cyclin A/B1 associated events during G2/M transition
    Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


    4 Kegg Pathways  (Kegg details for CDC25C):
        Cell cycle
    Oocyte meiosis
    Progesterone-mediated oocyte maturation
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25C: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC25C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC25C (P303071, 2, 3 ENSP000003216564) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK1O147571, 3, ENSP000002789164EBI-974439,EBI-974488 I2D: score=3 STRING: ENSP00000278916
    YWHAEP622582, 3, ENSP000002643354MINT-8008886 I2D: score=2 STRING: ENSP00000264335
    CDK1P064931, 3EBI-974439,EBI-444308 I2D: score=5 
    PLK1P533502, 3, ENSP000003000934MINT-16690 MINT-50542 MINT-16691 I2D: score=5 STRING: ENSP00000300093
    YWHAZP631042, 3, ENSP000003095034MINT-3294433 I2D: score=3 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS11139144
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000087mitotic M phase ----
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CDC25C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]

    2 HMDB Compounds for CDC25C    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for CDC25C gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 94.8 322 8626400 (4), 1360008 (4), 11356684 (3), 12149261 (3) (see all 99)
    vanadate 75.9 24 10569804 (2), 8626400 (1), 9275062 (1), 10978247 (1) (see all 23)
    sodium orthovanadate 75.5 17 7829501 (2), 1645256 (1), 7498427 (1), 10978247 (1) (see all 16)
    tyrosine 75.3 104 1913817 (6), 1655274 (3), 10773618 (2), 15827333 (2) (see all 78)
    3-tyrosine 75.1 2 12175337 (1), 12763027 (1)
    phenylarsine oxide 71.9 16 12761345 (2), 7997241 (2), 7589239 (1), 8617880 (1) (see all 11)
    bis(maltolato)oxovanadium(iv) 71.4 1 8910360 (1)
    phosphothreonine 70.5 3 15140384 (1), 9182566 (1), 11013245 (1)
    bpv(phen) 69.7 4 12536146 (1), 12375165 (1), 12759336 (1)
    phosphoserine 65.6 4 15140384 (1), 9182566 (1), 16916641 (1), 11090625 (1)



    Find genes that share compounds with CDC25C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC25C gene (4 alternative transcripts): 
    NM_001287582.1  NM_001287583.1  NM_001790.4  NM_022809.3  

    Unigene Cluster for CDC25C:

    Cell division cycle 25C
    Hs.656  [show with all ESTs]
    Unigene Representative Sequence: NM_001790
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323760(uc003lcp.1 uc003lcr.1) ENST00000415130 ENST00000513970(uc011cyp.1 uc003lcs.1)
    ENST00000514555 ENST00000514017 ENST00000503022(uc003lct.1) ENST00000510119
    ENST00000504831 ENST00000356505(uc010jet.1) ENST00000357274(uc003lcu.1)
    ENST00000348983(uc003lcq.1)
    miRNA
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    hsa-miR-767-3p hsa-miR-1253
    SwitchGear 3'UTR luciferase reporter plasmidCDC25C 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC25C
      QuantiTect SYBR Green Assays in human, mouse, rat CDC25C
      QuantiFast Probe-based Assays in human, mouse, rat CDC25C

    Additional mRNA sequence: 

    AF086323.1 AF277723.1 AF277724.1 AF277725.1 AF277726.1 AF312681.1 AJ304504.1 AK097710.1 
    AK301828.1 BC019089.2 M34065.1 

    6 DOTS entries:

    DT.445068  DT.95078853  DT.92428592  DT.100762094  DT.202903  DT.100788753 

    Selected AceView cDNA sequences (see all 103):

    AF277726 AA970118 BM722159 AL525498 CR595730 AU098899 CR590865 CB161064 
    BU527942 AW779598 AW401554 AF277725 AW293748 CR605066 AU103727 CN482564 
    AK097710 AI937211 CR618165 CB159024 AF312681 BU507476 CB110938 BC019089 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                          -           -     -                                                               
    SP4:                          -           -     -                                                               


    ECgene alternative splicing isoforms for CDC25C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDC25C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCTCACA
    CDC25C Expression
    About this image


    CDC25C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    CDC25C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC25C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25C: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CDC25C
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC25C gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc25c1 , 5 cell division cycle 25 homolog C (S. pombe)5
    cell division cycle 25C1
    79.65(n)1
    71.02(a)1
      18 (18.71 cM)5
    125321  NM_009860.21  NP_033990.21 
     347329975 
    lizard
    (Anolis carolinensis)
    Reptilia CDC25C6
    cell division cycle 25C
    39(a)
    1 ↔ 1
    2(146477960-146501230)
    African clawed frog
    (Xenopus laevis)
    Amphibia xcdc25-32 cdc25 protein 75.06(n)    M94264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc25d6
    cell division cycle 25 homolog d
    25(a)
    1 ↔ 1
    1(55260650-55274851) ENSDARG00000075599
    fruit fly
    (Drosophila melanogaster)
    Insecta stg3 protein amino acid dephosphorylation
    protein tyrosine phosphatase less
    46(a)
    (best of 2)
      3 99A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-25.36
    cdc-25.46
    (see all 4)
    Protein CDC-25.4 (cdc-25.4) mRNA, complete cds
    (see all 4)
    26(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    III(8916417-8917929) WBGene00000388
    II(10188310-10189405) WBGene00000389
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIH1(YMR036C)4 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 less   --   13(343520-341856) 855052  NP_013750.1 


    ENSEMBL Gene Tree for CDC25C (if available)
    TreeFam Gene Tree for CDC25C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC25C gene
    CDC25B2  CDC25A2  
    3 SIMAP similar genes for CDC25C using alignment to 5 protein entries:     MPIP3_HUMAN (see all proteins):
    CDC25B    DKFZp686G14213    CDC25A

    Find genes that share paralogs with CDC25C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDC25C (see all 894)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383040501,2
    --137620550(+) GTTGTC/TTGGTA 2 -- ds50010--------
    rs1927256711,2
    --137620606(+) GGTGGC/GACGAT 2 -- ds50010--------
    rs1847999311,2
    --137620675(+) AGCTGG/TGACTA 2 -- ds50010--------
    rs115680101,2
    C,F--137620689(-) GTGGCG/ATGTGC 2 -- ds50011Minor allele frequency- A:0.01NS 170
    rs112424181,2
    C,F,H--137620690(-) ggtggC/Tgtgtg 2 -- ds50011Minor allele frequency- T:0.02NS 170
    rs115680091,2
    C,F--137620789(-) TTTGGG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.01NS 170
    rs1135817741,2
    C,F--137621011(+) GAAACT/AAAGAA 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs1508841421,2
    --137621045(+) GACAAA/CGCTCT 2 -- ut310--------
    rs1382541171,2
    --137621079(+) AAAGAG/TTTGGC 2 -- ut310--------
    rs38133201,2
    C,F,H--137621257(+) TGGTAG/ACCTGT 2 -- ut317Minor allele frequency- A:0.04EA NS NA 2080

    HapMap Linkage Disequilibrium report for CDC25C (137620954 - 137674044 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDC25C: --
    Human Gene Mutation Database (HGMD): CDC25C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC25C
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC25C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 157680    OMIM disorders: --

    3 diseases for CDC25C:    
    About MalaCards
    hyperapobetalipoproteinemia    plague    malaria

    1 disease from the University of Copenhagen DISEASES database for CDC25C:
    Cancer

    Find genes that share disorders with CDC25C           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDC25C gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 51.3 2 17172433 (1), 18408079 (1)
    cancer 43.9 30 17568790 (3), 16179969 (1), 20166845 (1), 19212959 (1) (see all 19)
    tumors 35.5 28 19074854 (3), 10022129 (2), 11149596 (2), 11972334 (1) (see all 22)
    colon carcinoma 29.3 1 11401329 (1)
    prostate cancer 29.3 13 16000564 (5), 15961392 (1), 19885599 (1), 20143254 (1) (see all 5)
    ovarian cancer 16.1 5 11356684 (3), 11205229 (2)
    breast cancer 12 2 18191419 (1), 20514472 (1)
    endometrial cancer 10.7 1 11356684 (1)
    prostate carcinoma 8.51 1 17936851 (1)
    glioblastoma 6.72 1 17525741 (1)

    Genetic Association Database (GAD): CDC25C
    Human Genome Epidemiology (HuGE) Navigator: CDC25C (11 documents)

    Export disorders for CDC25C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC25C gene, integrated from 10 sources (see all 674):
    (articles sorted by number of sources associating them with CDC25C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. (PubMed id 11078813)1, 2, 9 Bureik M....Wagner P. (Int. J. Oncol. 2000)
    2. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. (PubMed id 8119945)1, 2, 9 Strausfeld U.... Lamb N.J. (J. Biol. Chem. 1994)
    3. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. (PubMed id 14968113)1, 2, 9 Bahassi el M.... Stambrook P.J. (Oncogene 2004)
    4. The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. (PubMed id 14972559)1, 2, 9 Goh W.C.... Emerman M. (Virology 2004)
    5. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. (PubMed id 11202906)1, 2, 9 Roshak A.K....Marshall L.A. (Cell. Signal. 2000)
    6. Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. (PubMed id 11304565)1, 2, 9 Hernandez S.... Campo E. (Lab. Invest. 2001)
    7. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PubMed id 11139144)1, 2, 9 Wegener S.... Schaller H.C. (Eur. J. Cell Biol. 2000)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    9. Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study. (PubMed id 19626602)1, 4 Zheng Y.L....Harris C.C. (Int. J. Cancer 2010)
    10. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 995 HGNC: 1727 AceView: CDC25C Ensembl:ENSG00000158402 euGenes: HUgn995
    ECgene: CDC25C Kegg: 995 H-InvDB: CDC25C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC25C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC25C Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25c/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC25C gene:
    Search GeneIP for patents involving CDC25C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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