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CDC25C Gene

protein-coding   GIFtS: 67

GC05M137648
cell division cycle 25 homolog C (S. pombe)
(Previous names: cell division cycle 25C, cell division cycle 25 homolog C (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CDC25)
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Aliases &
Descriptions
for CDC25C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
cell division cycle 25 homolog C (S. pombe)1 2     phosphotyrosine phosphatase2
cell division cycle 25C1 2     CDC252
Dual specificity phosphatase Cdc25C2 3     m-phase inducer phosphatase 32
cell division cycle 25 homolog C (S. cerevisiae)1     EC 3.1.3.483
mitosis inducer CDC252     

External Ids:    HGNC: 17271   Entrez Gene: 9952   Ensembl: ENSG000001584027   UniProtKB: P303073   

Search outside databases for aliases for CDC25C gene

Previous GC identifers: GC05M137495 GC05M138296 GC05M137651 GC05M137697

Summaries
for CDC25C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for CDC25C:
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded
protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin
B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple
alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of
them is not known. (provided by RefSeq)

UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307
Function: Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for
progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity

"" summary for CDC25C:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25C

Genomic Views
for CDC25C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CDC25C gene upstream (promoter) region "":
NF-kappaB1   ATF-2   STAT5A   STAT3   Sp1   POU3F1   SRF   FOXO4   CUTL1   FOXF2   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CDC25C:  ""
MePH07824-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

CDC25C Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137648:  view genomic region     (about GC identifiers)

Start:
 137,620,954 bp from pter
End:
 137,667,524 bp from pter
Size:
 46,571 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  

Proteins
for CDC25C gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 3  
Size: 473 amino acids; 53365 Da
Subunit: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity
Subcellular location: Nucleus
Developmental stage: Expressed predominantly in G2 phase
PDB structures from "" and Proteopedia "" :
3BZI (3D) ""    
Secondary accessions: Q96PL3 Q9H168 Q9H2E8 Q9H2E9 Q9H2F1
Alternative splicing: 5 isoforms:  P30307-1   P30307-2   P30307-5   P30307-3   P30307-4   

Post-translational modifications:

  • Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the
    • phosphatase. Phosphorylated by PLK41
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001781.2  NP_073720.1  


    ENSEMBL proteins: 
    ENSP00000349821 ENSP00000345205 ENSP00000348898 ENSP00000321656 ENSP00000392631 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant CDC25C Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for CDC25C
    ""HuPro® and/or Recombinant Proteins from Abnova for CDC25C ""
    "" Origene Purified Recombinant Human Protein: CDC25C
    ""Novus Biologicals Proteins for CDC25C  ""
    Novus Biologicals Lysates for CDC25C
    ""Browse Sino Biological Recombinant Proteins  ""

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm EXP1828290 9278512 11063929 11897663 12766774
    GO:0005737 cytoplasm IEA--
    About this table

    "" CDC25C for ontologies           About GeneDecksing



    Antibodies for CDC25C: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of CDC25C
    ""Sigma-Aldrich Antibody Arrays and Antibodies for CDC25C
    ""R&D Systems Antibodies for CDC25C
    ""Cell Signaling Technology (CST) Antibodies for CDC25C 
    ""Monoclonal and Polyclonal Antibodies from Abnova (CDC25C)
    "" Origene Antibodies (see all 3): CDC25C ""
    ""Novus Biologicals Antibodies for CDC25C
    ""Epitomics antibodies for CDC25C

    Assays for CDC25C: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for CDC25C

    Protein Domains/
    Families
    for CDC25C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" CDC25C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001763 Rhodanese-like
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30307

    ProtoNet protein and cluster: P30307

    2 Blocks protein families:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain

    Gene Function
    for CDC25C gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CDC25C)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CDC25C
    Origene shRNA RFP (see all 2): CDC25C
    Origene basic RS shRNA (see all 2): CDC25C

    ""Applied Biosystems Silencer® siRNAs for CDC25C
    ""Sigma-Aldrich siRNA Panels and siRNA for CDC25C
    Sigma-Aldrich shRNA Panels and shRNA for CDC25C
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CDC25C
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CDC25C
    Origene untagged cDNA clones in CMV expression vector (see all 2): CDC25C
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: MPIP3_HUMAN, P30307
    Function: Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for
    progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme Number (IUBMB): EC 3.1.3.48 

    Genatlas biochemistry entry for CDC25C:
    cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF)
    component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721 phosphoprotein phosphatase activity EXP1828290
    GO:0004725 protein tyrosine phosphatase activity NAS11078813
    GO:0005515 protein binding IPI16330544 17110335 17349584
    GO:0016787 hydrolase activity IEA--
    GO:0050699 WW domain binding IPI10037602
    About this table

    "" CDC25C for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 1 allele"") (MGI details for Cdc25c):

    digestive/alimentaryendocrine/exocrine glandgrowth/sizelife span-post-weaning/agingnormal

    "" CDC25C for phenotypes           About GeneDecksing

    Pathways & Interactions
    for CDC25C gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" CDC25C for pathways           About GeneDecksing

    2 "" Millipore Pathways for CDC25C
      ""  Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Cell cycle (generic schema)

    5/6 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  CDC25C  (Your Favorite Gene powered by Ingenuity) (see all 6 )
      ""  Hereditary Breast Cancer Signaling
    Role of CHK Proteins in Cell Cycle Checkpoint Control
    ATM Signaling
    Molecular Mechanisms of Cancer
    Mitotic Roles of Polo-Like Kinase

    5/8 "" GeneAssist Pathways for CDC25C (see all 8 )
      ""  p38 Signaling
    Mitotic Roles of Polo-Like Kinase
    ATM Pathway
    Molecular Mechanisms of Cancer
    Chks in Checkpoint Regulation

    3 "" Kegg Pathways  (Kegg details for CDC25C):
      ""  hsa04110 Cell cycle
    hsa04114 Oocyte meiosis
    hsa04914 Progesterone-mediated oocyte maturation

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC25C

    5/30 Interacting proteins for CDC25C (ENSP000003216563 P303071, 2) via UniProtKB, MINT, and/or STRING (see all 30 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK1O147571STRING: ENSP00000278916 EBI-974439,EBI-974488
    PPP2R5DQ147381STRING: ENSP00000230402 EBI-974439,EBI-396563
    PLK1P533502STRING: ENSP00000300093 MINT-16690 MINT-50542 MINT-16691
    YWHAZP631042STRING: ENSP00000309503 MINT-3294433
    CDC2P064931EBI-974439,EBI-444308
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079 regulation of cyclin-dependent protein kinase activity TAS11139144
    GO:0000087 M phase of mitotic cell cycle NAS--
    GO:0006260 DNA replication EXP12791985
    GO:0006470 protein amino acid dephosphorylation IEA--
    GO:0007049 cell cycle IEA--
    About this table

    "" CDC25C for ontologies           About GeneDecksing


    Drugs & Compounds
    for CDC25C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" CDC25C for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for CDC25C
    ""Sigma-Aldrich Small Molecules for CDC25C:
    Small Molecule - Inhibitor

    "" Compounds for CDC25C available from Tocris Bioscience
    CompoundAction CAS number
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]
    NSC 663284Potent, selective Cdc25 phosphatase inhibitor[383907-43-5]
    About this table


    10/238 ""Novoseek chemical compound relationships for CDC25C gene (see all 238 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 100.00 593 8150231 (8), 8308031 (5), 2982079 (5), 11579215 (5) (see all 100)
    sodium orthovanadate 91.74 47 7829501 (2), 7742786 (2), 2434835 (2), 9857490 (1) (see all 44)
    tyrosine 85.29 158 1913817 (6), 1655274 (4), 8253766 (3), 7680559 (3) (see all 100)
    vanadate 78.96 61 2450879 (2), 10569804 (2), 9479013 (1), 9275062 (1) (see all 59)
    phenylarsine oxide 34.01 21 8799722 (2), 7997241 (2), 12761345 (2), 9804578 (1) (see all 18)
    bpv(phen) 16.01 7 8567756 (1), 17113080 (1), 16814776 (1), 12759336 (1) (see all 7)
    phosphoserine 11.09 10 2989019 (2), 9182566 (1), 1719511 (1), 16916641 (1) (see all 9)
    p-nitrophenyl phosphate 11.01 9 8430088 (1), 7589546 (1), 7498427 (1), 6822491 (1) (see all 9)
    phosphothreonine 10.74 7 2989019 (2), 9182566 (1), 17307877 (1), 15722522 (1) (see all 6)
    genistein 10.12 18 17706963 (4), 12514295 (2), 9707554 (1), 9670916 (1) (see all 14)
    About this table


    Transcripts
    for CDC25C gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CDC25C)
    ""Applied Biosystems Silencer® siRNAs:  NM_001790  NM_022809  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CDC25C
    Origene shRNA RFP (see all 2): CDC25C
    Origene basic RS shRNA (see all 2): CDC25C

    ""Sigma-Aldrich siRNA Panels and siRNA for CDC25C
    Sigma-Aldrich shRNA Panels and shRNA for CDC25C
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate CDC25C: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_001790  NM_022809  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CDC25C
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CDC25C
    Origene untagged cDNA clones in CMV expression vector (see all 2): CDC25C
    Primers:"" Origene genome-wide validated SYBR primer pairs: CDC25C
    ""SABiosciences RT2 qPCR Primer Assay for CDC25C: PPH02198A ""

    REFSEQ mRNAs for CDC25C gene (2 alternative transcripts): 

    NM_001790.3  NM_022809.2  

    Additional cDNA sequence: 

    AF086323.1 AF277723.1 AF277724.1 AF277725.1 AF277726.1 AF312681.1 AJ304504.1 AK097710.1 
    AK301828.1 BC019089.2 CR590865.1 CR595730.1 CR605066.1 CR618165.1 M34065.1 

    6 DOTS entries:

    DT.445068  DT.95078853  DT.92428592  DT.100762094  DT.202903  DT.100788753 

    24/103 AceView cDNA sequences (see all 103 ):

    BU507476 AI937211 AK097710 CR590865 AF277725 AW401554 CN482564 CR595730 
    AF277726 AW779598 AF312681 AW293748 CR605066 CR618165 CB159024 AJ304504 
    AU098899 CB161064 AU103727 AA970118 BM722159 AL525498 BU527942 CB110938 

    "" highest scoring ESTs for CDC25C:

    M34065 AA206572 AK097710 AU098899 AU125025 BC019089 BF689465 BG530198 BG761656 BI828606 

    Unigene Cluster for CDC25C:

    Cell division cycle 25 homolog C (S. pombe)
    Hs.656  [show with all ESTs]
    Unigene Representative Sequence: NM_001790


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                          -           -     -                                                               
    SP4:                          -           -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for CDC25C

    5 Ensembl transcripts including schematic representations:
    ENST00000357274  ENST00000348983  ENST00000356505  ENST00000323760  ENST00000415130  

    Expression
    for CDC25C gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    CDC25C expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for CDC25C

    1""  / 2""  / 3""

    5 probe-sets matching CDC25C gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1584_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M34065 1.00 1.00 1.00 1
    217010_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF277724 0.60 1.00 0.82 1
    205167_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001790 0.60 1.00 0.82 1
    217010_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    205167_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" CDC25C for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCTTCTCACA

    SOURCE GeneReport for Unigene cluster: Hs.656

    Expression variation in blood from EXPOLDB for CDC25C

    Primers:"" Origene genome-wide validated SYBR primer pairs: CDC25C ""
    ""SABiosciences RT2 qPCR Primer Assay for CDC25C: PPH02198A ""

    Orthologs
    for CDC25C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for CDC25C gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CDC25C1   -- cell division cycle 25 homolog C (S. pombe) 86.79(n)
    80.3(a)    		 610456  XM_847966.1  XP_853059.1 
    chimpanzee
    (Pan troglodytes)    		 CDC25C1   -- cell division cycle 25 homolog C (S. pombe) 99.44(n)
    98.52(a)    		 746151  XM_001171027.1  XP_001171027.1 
    cow
    (Bos taurus)    		 CDC25C1   -- cell division cycle 25 homolog C (S. pombe) 86.54(n)
    82.45(a)    		 507731  XM_867870.2  XP_872963.2 
    rat
    (Rattus norvegicus)    		 Cdc25c1   -- cell division cycle 25 homolog C (S. pombe) 75.74(n)
    68.58(a)    		 307511  XM_226071.4  XP_226071.4 
    mouse
    (Mus musculus)    		 Cdc25c1, 5 18 (15.00 cM)5
    		 cell division cycle 25 homolog C (S. pombe)1, 5 79.65(n)1
    71.02(a)1    		 125321  NM_009860.21  NP_033990.21 
     AA4380795  AF3471155  (see all 14)
    About this table        Species with no ortholog for CDC25C

    ENSEMBL Gene Tree for CDC25C

    Paralogs
    for CDC25C gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for CDC25C gene
    CDC25B2  CDC25A2  

    "" CDC25C for paralogs           About GeneDecksing


    Genomic Variants
    for CDC25C gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback    		  --

    Disorders & Mutations
    for CDC25C gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

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    "" CDC25C for disorders           About GeneDecksing

    OMIM: 157680

    10/80 ""Novoseek disease relationships for CDC25C gene (see all 80 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    nuclear accumulation 10.46 10 11313932 (3), 12034754 (2), 9923681 (1), 14968113 (1) (see all 7)
    dna replication damage 7.79 3 12775939 (1), 11133168 (1), 10068474 (1)
    growth arrest 5.07 9 8673064 (2), 17611691 (2), 10853038 (2), 18208561 (1) (see all 6)
    18 trisomy 2.23 3 1308852 (2), 9179533 (1)
    endometrial hyperplasia 1.36 2 12931023 (1), 12124347 (1)
    keratoconus 1.34 3 10079136 (3)
    cytoplasmic accumulation 1.16 1 19933706 (1)
    leukemia; myelomonocytic 1.15 1 16619512 (1)
    ataxia telangiectasia 1.00 3 17172433 (1), 16645841 (1), 15975956 (1)
    temperature-sensitive mutation 0.97 1 1648229 (1)
    About this table

    Human Genome Epidemiology Navigator: CDC25C (7 documents)

    Medical News
    for CDC25C gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for CDC25C gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/607 PubMed articles for CDC25C gene (see all 607 ):

    Search for CDC25C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    Genome Databases showing CDC25C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 995 HGNC: 1727 AceView: CDC25C Ensembl:ENSG00000158402 euGenes: HUgn995
    ECgene: CDC25C Kegg: 995 H-InvDB: CDC25C

    Other Databases showing CDC25C gene

    (According to HUGE)
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    Specialized Databases showing CDC25C gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for CDC25C Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25c/

    Intellectual Property
    for CDC25C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for CDC25C gene: ""
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    Services
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    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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