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Aliases for CDC25C Gene

Aliases for CDC25C Gene

  • Cell Division Cycle 25C 2 3
  • EC 3.1.3.48 4 63
  • Cell Division Cycle 25 Homolog C (S. Cerevisiae) 2
  • Protein Phosphatase 1, Regulatory Subunit 60 3
  • Cell Division Cycle 25 Homolog C (S. Pombe) 2
  • Dual Specificity Phosphatase CDC25C 3
  • Dual Specificity Phosphatase Cdc25C 4
  • M-Phase Inducer Phosphatase 3 3
  • Phosphotyrosine Phosphatase 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 60 2
  • Mitosis Inducer CDC25 3
  • PPP1R60 3
  • CDC25 3

External Ids for CDC25C Gene

Previous HGNC Symbols for CDC25C Gene

  • CDC25

Previous GeneCards Identifiers for CDC25C Gene

  • GC05M137495
  • GC05M137651
  • GC05M137697
  • GC05M137648
  • GC05M132811
  • GC05M137620

Summaries for CDC25C Gene

Entrez Gene Summary for CDC25C Gene

  • This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25C Gene

CDC25C (Cell Division Cycle 25C) is a Protein Coding gene. Diseases associated with CDC25C include plague and glucose-6-phosphate dehydrogenase deficiency. Among its related pathways are Akt Signaling and ERK Signaling. GO annotations related to this gene include protein kinase binding and WW domain binding. An important paralog of this gene is CDC25A.

UniProtKB/Swiss-Prot for CDC25C Gene

  • Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Tocris Summary for CDC25C Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25 activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation, interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex. Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex. Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit mitosis.

Gene Wiki entry for CDC25C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25C Gene

Genomics for CDC25C Gene

Regulatory Elements for CDC25C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC25C Gene

Start:
138,285,265 bp from pter
End:
138,338,355 bp from pter
Size:
53,091 bases
Orientation:
Minus strand

Genomic View for CDC25C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC25C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25C Gene

Proteins for CDC25C Gene

  • Protein details for CDC25C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30307-MPIP3_HUMAN
    Recommended name:
    M-phase inducer phosphatase 3
    Protein Accession:
    P30307
    Secondary Accessions:
    • D3DQB8
    • Q96PL3
    • Q9H168
    • Q9H2E8
    • Q9H2E9
    • Q9H2F1

    Protein attributes for CDC25C Gene

    Size:
    473 amino acids
    Molecular mass:
    53365 Da
    Quaternary structure:
    • Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3 proteins. When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for CDC25C Gene

    Alternative splice isoforms for CDC25C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25C Gene

Proteomics data for CDC25C Gene at MOPED

Selected DME Specific Peptides for CDC25C Gene

Post-translational modifications for CDC25C Gene

  • Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC25C (CDC25C)

Domains for CDC25C Gene

Gene Families for CDC25C Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • PTP3 :Protein tyrosine phosphatases / Class III Cys-based PTPs

Protein Domains for CDC25C Gene

Suggested Antigen Peptide Sequences for CDC25C Gene

Graphical View of Domain Structure for InterPro Entry

P30307

UniProtKB/Swiss-Prot:

MPIP3_HUMAN :
  • P30307
Domain:
  • Contains 1 rhodanese domain.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25C: view

Function for CDC25C Gene

Molecular function for CDC25C Gene

GENATLAS Biochemistry: cdc25 protein phosphatase,non receptor type,form C,complexing with CDC2 (M phase promoting factor (MPF) component),regulator of the cell cycle entry into mitosis by dephosphorylating the protein kinase CDC2
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Enzyme Numbers (IUBMB) for CDC25C Gene

Gene Ontology (GO) - Molecular Function for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity NAS 11078813
GO:0005515 protein binding IPI 11836499
GO:0019901 protein kinase binding IPI 14968113
GO:0050699 WW domain binding IPI 10037602
genes like me logo Genes that share ontologies with CDC25C: view
genes like me logo Genes that share phenotypes with CDC25C: view

Animal Models for CDC25C Gene

MGI Knock Outs for CDC25C:

Animal Model Products

CRISPR Products

miRNA for CDC25C Gene

miRTarBase miRNAs that target CDC25C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC25C

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CDC25C Gene

Localization for CDC25C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC25C Gene COMPARTMENTS Subcellular localization image for CDC25C gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 14968113
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC25C: view

Pathways for CDC25C Gene

genes like me logo Genes that share pathways with CDC25C: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CDC25C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 11139144
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000087 mitotic M phase --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
genes like me logo Genes that share ontologies with CDC25C: view

Compounds for CDC25C Gene

(1) Tocris Compounds for CDC25C Gene

Compound Action Cas Number
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor [93718-83-3]

(2) HMDB Compounds for CDC25C Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(81) Novoseek inferred chemical compound relationships for CDC25C Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 94.8 161
vanadate 75.9 24
sodium orthovanadate 75.5 17
tyrosine 75.3 87
3-tyrosine 75.1 2
genes like me logo Genes that share compounds with CDC25C: view

Transcripts for CDC25C Gene

Unigene Clusters for CDC25C Gene

Cell division cycle 25C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC25C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2:
SP3: - - -
SP4: - - -

Relevant External Links for CDC25C Gene

GeneLoc Exon Structure for
CDC25C
ECgene alternative splicing isoforms for
CDC25C

Expression for CDC25C Gene

mRNA expression in normal human tissues for CDC25C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC25C Gene

This gene is overexpressed in Testis (18.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC25C Gene

SOURCE GeneReport for Unigene cluster for CDC25C Gene Hs.656

genes like me logo Genes that share expressions with CDC25C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDC25C Gene

Orthologs for CDC25C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC25C 35
  • 99.44 (n)
  • 98.52 (a)
CDC25C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC25C 35
  • 86.61 (n)
  • 82.24 (a)
CDC25C 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC25C 35
  • 86.86 (n)
  • 80.3 (a)
CDC25C 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc25c 35
  • 79.65 (n)
  • 71.02 (a)
Cdc25c 16
Cdc25c 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC25C 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cdc25c 35
  • 83.46 (n)
  • 78.46 (a)
lizard
(Anolis carolinensis)
Reptilia CDC25C 36
  • 39 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xcdc25-3 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25c 35
  • 57.86 (n)
  • 51.59 (a)
zebrafish
(Danio rerio)
Actinopterygii cdc25d 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stg 36
  • 28 (a)
ManyToMany
twe 36
  • 26 (a)
ManyToMany
stg 37
  • 46 (a)
twe 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-25.1 36
  • 14 (a)
ManyToMany
cdc-25.2 36
  • 17 (a)
ManyToMany
cdc-25.3 36
  • 26 (a)
ManyToMany
cdc-25.4 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 36
  • 31 (a)
OneToMany
Species with no ortholog for CDC25C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25C Gene

ENSEMBL:
Gene Tree for CDC25C (if available)
TreeFam:
Gene Tree for CDC25C (if available)

Paralogs for CDC25C Gene

Paralogs for CDC25C Gene

Selected SIMAP similar genes for CDC25C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDC25C: view

Variants for CDC25C Gene

Sequence variations from dbSNP and Humsavar for CDC25C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3734165 -- 138,325,745(+) TCTCA(C/T)TATGA intron-variant
rs3734166 - 138,329,634(+) GCAAC(A/G)TTTTG reference, missense, intron-variant
rs3734167 -- 138,329,773(+) TCCCC(C/G)CAGCT intron-variant
rs3813320 -- 138,285,568(+) TGGTA(A/G)CCTGT utr-variant-3-prime
rs4507482 -- 138,305,068(+) ACCTT(G/T)TCCAC intron-variant

Relevant External Links for CDC25C Gene

HapMap Linkage Disequilibrium report
CDC25C
Human Gene Mutation Database (HGMD)
CDC25C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDC25C Gene

Disorders for CDC25C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CDC25C Gene including...

Search for CDC25C Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDC25C Gene

(28) Novoseek inferred disease relationships for CDC25C Gene

Disease -log(P) Hits PubMed IDs
ataxia telangiectasia 51.3 2
cancer 43.9 21
tumors 35.5 26
colon carcinoma 29.3 1
prostate cancer 29.3 9

Relevant External Links for CDC25C

Genetic Association Database (GAD)
CDC25C
Human Genome Epidemiology (HuGE) Navigator
CDC25C
genes like me logo Genes that share disorders with CDC25C: view

No data available for UniProtKB/Swiss-Prot for CDC25C Gene

Publications for CDC25C Gene

  1. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. (PMID: 8119945) Strausfeld U. … Lamb N.J. (J. Biol. Chem. 1994) 3 4 23
  2. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. (PMID: 11078813) Bureik M. … Wagner P. (Int. J. Oncol. 2000) 3 4 23
  3. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PMID: 11139144) Wegener S. … Schaller H.C. (Eur. J. Cell Biol. 2000) 3 4 23
  4. Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. (PMID: 11304565) Hernandez S. … Campo E. (Lab. Invest. 2001) 3 4 23
  5. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. (PMID: 11202906) Roshak A.K. … Marshall L.A. (Cell. Signal. 2000) 3 4 23

Products for CDC25C Gene

Sources for CDC25C Gene

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