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Aliases for CDC25B Gene

Aliases for CDC25B Gene

  • Cell Division Cycle 25B 2 3 5
  • EC 3.1.3.48 4 58
  • Cell Division Cycle 25 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 25 Homolog B (S. Pombe) 2
  • Dual Specificity Phosphatase Cdc25B 4
  • CDC25HU2 4

External Ids for CDC25B Gene

Previous GeneCards Identifiers for CDC25B Gene

  • GC20P003765
  • GC20P003724

Summaries for CDC25B Gene

Entrez Gene Summary for CDC25B Gene

  • CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25B Gene

CDC25B (Cell Division Cycle 25B) is a Protein Coding gene. Diseases associated with CDC25B include Breast Cancer. Among its related pathways are DNA Damage and HIV Life Cycle. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25A.

UniProtKB/Swiss-Prot for CDC25B Gene

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Tocris Summary for CDC25B Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression.

Gene Wiki entry for CDC25B Gene

Additional gene information for CDC25B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25B Gene

Genomics for CDC25B Gene

Regulatory Elements for CDC25B Gene

Enhancers for CDC25B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H003795 1.7 FANTOM5 ENCODE dbSUPER 33.7 +15.3 15282 14 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CDC25B ENSG00000229539 VPS16 SPEF1 PTPRA UBOX5 ADAM33 PANK2 LINC01730 GC20P003786
GH20H003780 1.6 Ensembl ENCODE dbSUPER 30.1 -2.6 -2602 6 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF766 ZNF143 CDC25B C20orf27 GC20M003787 SPEF1 GC20M003786
GH20H003777 1 Ensembl ENCODE 28.5 -8.5 -8481 2 KLF1 MAX ZFHX2 GLIS2 POLR2A ZBTB48 ATF7 ZBTB20 THAP11 EGR2 CDC25B AP5S1 PANK2 ENSG00000229539 SPEF1 C20orf27
GH20H003842 1.4 Ensembl ENCODE dbSUPER 20.3 +56.5 56468 1 ELF3 ATF1 MLX KLF17 RAD21 RARA TCF12 SLC30A9 GLIS2 FOS CDC25B AP5S1 CENPB PANK2 ENSG00000229539 MAVS
GH20H003845 1.3 ENCODE dbSUPER 20.4 +59.8 59846 3 HDGF ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF207 SP3 CDC25B AP5S1 UBOX5 CENPB PANK2 ENSG00000229539 HSPA12B MAVS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC25B on UCSC Golden Path with GeneCards custom track

Promoters for CDC25B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133813 -172 1601 ARID4B SIN3A BRCA1 SLC30A9 ZNF143 RUNX3 SP5 MXD4 MIER2 REST

Transcription factor binding sites by QIAGEN in the CDC25B gene promoter:

Genomic Location for CDC25B Gene

Chromosome:
20
Start:
3,786,772 bp from pter
End:
3,806,121 bp from pter
Size:
19,350 bases
Orientation:
Plus strand

Genomic View for CDC25B Gene

Genes around CDC25B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC25B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC25B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25B Gene

Proteins for CDC25B Gene

  • Protein details for CDC25B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30305-MPIP2_HUMAN
    Recommended name:
    M-phase inducer phosphatase 2
    Protein Accession:
    P30305
    Secondary Accessions:
    • D3DVY1
    • D3DVY2
    • D3DVY3
    • D3DVY4
    • O43551
    • Q13971
    • Q5JX77
    • Q6RSS1
    • Q9BRA6

    Protein attributes for CDC25B Gene

    Size:
    580 amino acids
    Molecular mass:
    64987 Da
    Quaternary structure:
    • Interacts with MAPK14 and 14-3-3 proteins.

    Three dimensional structures from OCA and Proteopedia for CDC25B Gene

    Alternative splice isoforms for CDC25B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25B Gene

Selected DME Specific Peptides for CDC25B Gene

P30305:
  • CEFSSERGPRMCR
  • FHCEFSS
  • LKGGYKEFF
  • DCRYPYEYEGGHIK
  • GKHQDLKY

Post-translational modifications for CDC25B Gene

  • Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
  • Ubiquitination at Lys71, Lys204, Lys398, and Lys469
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC25B (CDC25B)
  • Abcam antibodies for CDC25B

Domains & Families for CDC25B Gene

Gene Families for CDC25B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDC25B Gene

Graphical View of Domain Structure for InterPro Entry

P30305

UniProtKB/Swiss-Prot:

MPIP2_HUMAN :
  • Belongs to the MPI phosphatase family.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25B: view

Function for CDC25B Gene

Molecular function for CDC25B Gene

GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form B,regulator of the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by B-type cyclins.
UniProtKB/Swiss-Prot Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Enzyme Numbers (IUBMB) for CDC25B Gene

Phenotypes From GWAS Catalog for CDC25B Gene

Gene Ontology (GO) - Molecular Function for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity TAS,IEA 9188863
GO:0005515 protein binding IPI 7644510
GO:0016787 hydrolase activity IEA --
GO:0019901 protein kinase binding IPI 12400006
genes like me logo Genes that share ontologies with CDC25B: view
genes like me logo Genes that share phenotypes with CDC25B: view

Animal Models for CDC25B Gene

MGI Knock Outs for CDC25B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC25B Gene

Localization for CDC25B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC25B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA,IEA 15908796
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDC25B: view

Pathways & Interactions for CDC25B Gene

genes like me logo Genes that share pathways with CDC25B: view

SIGNOR curated interactions for CDC25B Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS 12400006
GO:0000278 mitotic cell cycle TAS 9188863
GO:0001556 oocyte maturation IEA --
GO:0006468 protein phosphorylation IDA 17332740
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with CDC25B: view

Drugs & Compounds for CDC25B Gene

(10) Drugs for CDC25B Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Cysteinesulfonic Acid Experimental Pharma Target 0
NSC 95397 Pharma Selective Cdc25 dual specificity phosphatase inhibitor 0
NSC 663284 Pharma 0

(5) Additional Compounds for CDC25B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(1) Tocris Compounds for CDC25B Gene

Compound Action Cas Number
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor 93718-83-3

(2) ApexBio Compounds for CDC25B Gene

Compound Action Cas Number
NSC 663284 383907-43-5
NSC 95397 93718-83-3
genes like me logo Genes that share compounds with CDC25B: view

Drug Products

Transcripts for CDC25B Gene

Unigene Clusters for CDC25B Gene

Cell division cycle 25B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - -
SP9:
SP10: - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - -
SP14: - - -
SP15:

ExUns: 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:

Relevant External Links for CDC25B Gene

GeneLoc Exon Structure for
CDC25B
ECgene alternative splicing isoforms for
CDC25B

Expression for CDC25B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC25B Gene

Protein differential expression in normal tissues from HIPED for CDC25B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC25B Gene



Protein tissue co-expression partners for CDC25B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC25B Gene:

CDC25B

SOURCE GeneReport for Unigene cluster for CDC25B Gene:

Hs.153752

Evidence on tissue expression from TISSUES for CDC25B Gene

  • Nervous system(4.9)
  • Lung(3.4)
  • Intestine(2.6)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CDC25B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC25B Gene

Orthologs for CDC25B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC25B 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia CDC25B 33 34
  • 87.97 (n)
dog
(Canis familiaris)
Mammalia CDC25B 33 34
  • 85.53 (n)
mouse
(Mus musculus)
Mammalia Cdc25b 33 16 34
  • 81.33 (n)
rat
(Rattus norvegicus)
Mammalia Cdc25b 33
  • 81.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC25B 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC25B 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25b 33
  • 61.78 (n)
zebrafish
(Danio rerio)
Actinopterygii cdc25 34
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stg 35 34
  • 38 (a)
twe 35 34
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea cdc-25.3 34
  • 24 (a)
ManyToMany
cdc-25.2 34
  • 23 (a)
ManyToMany
cdc-25.4 34
  • 23 (a)
ManyToMany
cdc-25.1 34
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 34
  • 37 (a)
OneToMany
Species where no ortholog for CDC25B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25B Gene

ENSEMBL:
Gene Tree for CDC25B (if available)
TreeFam:
Gene Tree for CDC25B (if available)

Paralogs for CDC25B Gene

Paralogs for CDC25B Gene

(3) SIMAP similar genes for CDC25B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CDC25B: view

Variants for CDC25B Gene

Sequence variations from dbSNP and Humsavar for CDC25B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000143436 -- 3,790,557(+) TGGCT(C/T)ACGCC intron-variant
rs1000273837 -- 3,797,420(+) ACCAG(-/TCA)TCAAC intron-variant
rs1000546648 -- 3,796,185(+) CGCCT(C/T)TTGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000681217 -- 3,796,566(+) AGGCT(C/T)GGCTC intron-variant, nc-transcript-variant, reference, missense
rs1000819813 -- 3,803,699(+) TGCAT(A/G)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC25B Gene

Variant ID Type Subtype PubMed ID
esv3385581 CNV insertion 20981092
nsv1071676 CNV deletion 25765185
nsv585285 CNV loss 21841781
nsv585286 CNV loss 21841781
nsv828673 CNV gain 20364138
nsv833899 CNV loss 17160897

Variation tolerance for CDC25B Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC25B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC25B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25B Gene

Disorders for CDC25B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC25B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDC25B

Genetic Association Database (GAD)
CDC25B
Human Genome Epidemiology (HuGE) Navigator
CDC25B
Tumor Gene Database (TGDB):
CDC25B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC25B
genes like me logo Genes that share disorders with CDC25B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC25B Gene

Publications for CDC25B Gene

  1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PMID: 1836978) Galaktionov K … Beach D (Cell 1991) 2 3 4 22 60
  2. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. (PMID: 15908796) Mirey G … Ducommun B (Cell cycle (Georgetown, Tex.) 2005) 3 4 22 60
  3. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. (PMID: 15128871) Dutertre S … Ducommun B (Journal of cell science 2004) 3 4 22 60
  4. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. (PMID: 12400006) Davezac N … Tassan JP (Oncogene 2002) 3 4 22 60
  5. Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? (PMID: 9188863) Baldin V … Ducommun B (Oncogene 1997) 3 4 22 60

Products for CDC25B Gene

Sources for CDC25B Gene

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