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CDC25B Gene

protein-coding   GIFtS: 73
GCID: GC20P003771

Cell Division Cycle 25B

(Previous names: cell division cycle 25B, cell division cycle 25 homolog...)
  Search for CDC25B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 25B1 2     Cell Division Cycle 25 Homolog B (S. Pombe)1
Dual Specificity Phosphatase Cdc25B2 3     M-Phase Inducer Phosphatase 22
EC 3.1.3.483 8     CDC25HU23
Cell Division Cycle 25 Homolog B (S. Cerevisiae)1     

External Ids:    HGNC: 17261   Entrez Gene: 9942   Ensembl: ENSG000001012247   OMIM: 1169495   UniProtKB: P303053   

Export aliases for CDC25B gene to outside databases

Previous GC identifers: GC20P003765 GC20P003724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC25B Gene:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by
removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and
the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1
phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although
its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CDC25B Gene:
CDC25B (cell division cycle 25B) is a protein-coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein kinase binding. An important paralog of this gene is CDC25A.

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent
manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a
different level of activity

summary for CDC25B Gene:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC25B gene promoter:
         GR   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC25B promoter sequence
   Search Chromatin IP Primers for CDC25B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC25B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CDC25B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003771:  view genomic region     (about GC identifiers)

Start:
3,767,578 bp from pter      End:
3,786,762 bp from pter
Size:
19,185 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 2  
Size: 580 amino acids; 64987 Da
Subunit: Interacts with MAPK14 and 14-3-3 proteins
Selected PDB 3D structures from and Proteopedia for CDC25B (see all 15):
1CWR (3D)        1CWS (3D)        1CWT (3D)        1QB0 (3D)        1YM9 (3D)        1YMD (3D)    
Secondary accessions: D3DVY1 D3DVY2 D3DVY3 D3DVY4 O43551 Q13971 Q5JX77 Q6RSS1 Q9BRA6
Alternative splicing: 4 isoforms:  P30305-1   P30305-2   P30305-3   P30305-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC25B: NX_P30305

Explore proteomics data for CDC25B at MOPED

Post-translational modifications: 

  • Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein.
    Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis.
    Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis.
    Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins1
  • Ubiquitination2 at Lys71, Lys204, Lys398, Lys469
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDC25B (P30305) (see all 5)
     FHCEFSS  GKHQDLKY  LKGGYKEFF  CEFSSERGPRMCR 


    See CDC25B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001274445.1  NP_001274446.1  NP_001274447.1  NP_001274448.1  NP_001274449.1  NP_001274451.1  NP_001274453.1  NP_004349.1  
    NP_068658.1  NP_068659.1  

    ENSEMBL proteins: 
     ENSP00000245960   ENSP00000405972   ENSP00000339170   ENSP00000339125   ENSP00000368918  
    Reactome Protein details: P30305

    CDC25B Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for CDC25B
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    OriGene Protein Over-expression Lysate for CDC25B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDC25B
    GenScript Custom Purified and Recombinant Proteins Services for CDC25B
    Novus Biologicals CDC25B Proteins
    Novus Biologicals CDC25B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC25B

     
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    CDC25B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CDC25B
    Cell Signaling Technology (CST) Antibodies for CDC25B 
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    OriGene Custom Antibody Services for CDC25B
    Novus Biologicals CDC25B Antibodies
    Search for Antibodies for CDC25B at Abcam
    Cloud-Clone Corp. Antibodies for CDC25B
    ThermoFisher Antibodies for CDC25B
    LSBio Antibodies in human, mouse, rat for CDC25B

    CDC25B Assay Products:

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    Search eBioscience for ELISAs for CDC25B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTP3: Protein tyrosine phosphatases / Class III Cys-based PTPs

    2 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30305

    ProtoNet protein and cluster: P30305

    2 Blocks protein domains:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain


    Find genes that share domains with CDC25B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPIP2_HUMAN, P30305
    Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
    Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent
    manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a
    different level of activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Stimulated by B-type cyclins

         Genatlas biochemistry entry for CDC25B:
    cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form
    B,regulator of the cell cycle

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity TAS9188863
    GO:0005515protein binding IPI10713667
    GO:0019901protein kinase binding IPI12400006
         
    Find genes that share ontologies with CDC25B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDC25B:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdc25b):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with CDC25B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdc25btm1Pjd for CDC25B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC25B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC25B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC25B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC25B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC25B:
    hsa-mir-148a-3p (MIRT026017), hsa-mir-296-3p (MIRT038444), hsa-mir-744-5p (MIRT037634), hsa-mir-26b-5p (MIRT030153), hsa-let-7a-5p (MIRT052555), hsa-mir-7-5p (MIRT025904)

    Block miRNA regulation of human, mouse, rat CDC25B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC25B (see all 20):
    hsa-miR-520f hsa-miR-148b hsa-miR-188-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-200a hsa-miR-141 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidCDC25B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC25B
    Predesigned siRNA for gene silencing in human, mouse, rat CDC25B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC25B

    Clone
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    OriGene clones in human, mouse for CDC25B (see all 19)
    OriGene ORF clones in mouse, rat for CDC25B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC25B (NM_004358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25B

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC25B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MPIP2_HUMAN, P30305: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle pole
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA15908796
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CDC25B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC25B About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5CDK-mediated phosphorylation and removal of Cdc6
    Cyclin A-Cdk2-associated events at S phase entry0.85
    S Phase0.78


    Find genes that share SuperPaths with CDC25B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC25B
        14-3-3 and Cell Cycle Regulation
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for CDC25B
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDC25B
        Cell cycle Cell cycle (generic schema)
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for CDC25B (see all 11)
        MAPK signaling pathway
    Cell cycle
    Senescence and Autophagy
    Integrated Breast Cancer Pathway
    Prostate Cancer

    3 Reactome Pathways for CDC25B
        Cyclin B2 mediated events
    Cyclin A:Cdk2-associated events at S phase entry
    Cyclin A/B1 associated events during G2/M transition


    4 Kegg Pathways  (Kegg details for CDC25B):
        MAPK signaling pathway
    Cell cycle
    Progesterone-mediated oocyte maturation
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25B: 
              Cell Cycle in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC25B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC25B (P303051, 2, 3 ENSP000002459604) via UniProtKB, MINT, STRING, and/or I2D (see all 225)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, 3, ENSP000003095034EBI-1051746,EBI-347088 MINT-19329 MINT-8006377 MINT-17849 MINT-17850 MINT-8006848 MINT-25121 MINT-8007512 I2D: score=4 STRING: ENSP00000309503
    YWHABP319461, 2, 3, ENSP000003001614EBI-1051746,EBI-359815 MINT-19327 MINT-8006726 MINT-51064 MINT-51065 MINT-8007484 MINT-25122 I2D: score=5 STRING: ENSP00000300161
    YWHAEP622582, 3, ENSP000002643354MINT-51066 MINT-25123 MINT-8004866 MINT-51067 I2D: score=4 STRING: ENSP00000264335
    SFNP319472, 3, ENSP000003409894MINT-51068 MINT-51069 MINT-51070 MINT-8007498 I2D: score=2 STRING: ENSP00000340989
    YWHAGP619812, 3, ENSP000003063304MINT-8007491 I2D: score=1 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS12400006
    GO:0000087mitotic M phase ----
    GO:0000278mitotic cell cycle TAS9188863
    GO:0001556oocyte maturation IEA--
    GO:0006468protein phosphorylation IDA17332740

    Find genes that share ontologies with CDC25B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CDC25B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]

    1 HMDB Compound for CDC25B    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    3 DrugBank Compounds for CDC25B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteinesulfonic Acid-- --target--17139284 17016423
    Double Oxidized Cysteine-- --target--17139284 17016423
    Methyl Mercury Ion-- --target--17139284 17016423

    9 Novoseek inferred chemical compound relationships for CDC25B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 43.8 1 15003534 (1)
    tyrosine 40.1 9 14767478 (2), 20025242 (1), 15498512 (1), 1836978 (1) (see all 6)
    quinone 39.5 1 18802630 (1)
    hydroxyurea 27.4 3 15556082 (1), 10392903 (1), 9281587 (1)
    threonine 26.8 1 19075567 (1)
    alanine 9.72 5 17003105 (1), 19638579 (1), 19276368 (1), 15173315 (1)
    steroid 0 4 15193457 (3), 14559803 (1)
    estrogen 0 2 15193457 (1), 14559803 (1)
    cycloheximide 0 6 9281587 (2), 15456846 (1)



    Find genes that share compounds with CDC25B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC25B gene (12 alternative transcripts): 
    NM_001287516.1  NM_001287517.1  NM_001287518.1  NM_001287519.1  NM_001287520.1  NM_001287522.1  NM_001287524.1  NM_004358.4  
    NM_021872.3  NM_021873.3  NM_021874.2  NM_212530.1  

    Unigene Cluster for CDC25B:

    Cell division cycle 25B
    Hs.153752  [show with all ESTs]
    Unigene Representative Sequence: NM_021873
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467519 ENST00000245960(uc010zqk.2 uc010zqm.2 uc002wjl.3 uc002wjm.3 uc021waa.1 uc002wjn.3 uc002wjo.3 uc002wjp.3)
    ENST00000439880(uc010zql.2 uc002wjq.3) ENST00000340833 ENST00000480816
    ENST00000468979 ENST00000495915 ENST00000344256 ENST00000379598
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDC25B (see all 20):
    hsa-miR-520f hsa-miR-148b hsa-miR-188-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-200a hsa-miR-141 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidCDC25B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC25B
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC25B (NM_004358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25B
    Primer
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    OriGene qPCR primer pairs and template standards for CDC25B
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC25B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC25B
      QuantiTect SYBR Green Assays in human, mouse, rat CDC25B
      QuantiFast Probe-based Assays in human, mouse, rat CDC25B

    Additional mRNA sequence: 

    AK092713.1 AK295573.1 AK299028.1 AK299192.1 BC006395.2 BC009953.2 BC051711.1 BX640836.1 
    BX647988.1 FR695900.1 FR695901.1 M81934.1 S78187.1 Z68092.1 

    Selected DOTS entries (see all 28):

    DT.452676  DT.100812620  DT.95244406  DT.100812628  DT.101983619  DT.100812618  DT.100724666  DT.95244417 
    DT.100801781  DT.97859977  DT.100812626  DT.40116000  DT.100038305  DT.100812622  DT.95214264  DT.102822230 
    DT.120819392  DT.95183579  DT.100703642  DT.100738683  DT.120819356  DT.120819360  DT.120819365  DT.120819403 

    Selected AceView cDNA sequences (see all 474):

    CD671180 BQ934960 BE393404 AA349951 BQ951405 BQ961611 BU185038 BQ961938 
    BQ016223 BQ073746 BM992633 CR591656 CB159694 NM_021874 AI338486 BQ961457 
    BM017579 CB125501 BM563096 CR615304 BQ962413 AI953408 BC043344 BE676643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                    -     -     -     -     -                 -           -     -                 -                                         -     -         
    SP2:                    -     -     -     -     -     -           -           -     -                 -                                         -     -         
    SP3:                                            -                 -           -     -                 -                                         -     -         
    SP4:                                            -     -           -           -     -                 -                                         -     -         
    SP5:                                            -                 -           -     -                 -     -     -                             -     -         

    ExUns: 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                    -                                                   
    SP2:                    -                                                   
    SP3:                    -                                                   
    SP4:                    -                                                   
    SP5:                    -                                                   


    ECgene alternative splicing isoforms for CDC25B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDC25B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCCTGCA
    CDC25B Expression
    About this image

    CDC25B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC25B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153752
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25B: 
              Cell Cycle in human mouse rat
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC25B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc25b1 , 5 cell division cycle 25 homolog B (S. pombe)5
    cell division cycle 25B1
    81.33(n)1
    81.57(a)1
      2 (63.29 cM)5
    125311  NM_023117.41  NP_075606.11 
     1311869495 
    lizard
    (Anolis carolinensis)
    Reptilia CDC25B6
    cell division cycle 25B
    54(a)
    1 ↔ 1
    GL344063.1(70604-82411)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdc25b1 cell division cycle 25B 61.78(n)
    54.3(a)
      100036608  XM_002936293.2  XP_002936339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc256
    cell division cycle 25 homolog
    45(a)
    1 → many
    13(14776347-14790249) ENSDARG00000010792
    fruit fly
    (Drosophila melanogaster)
    Insecta stg3 protein amino acid dephosphorylation
    protein tyrosine more
    38(a)
    (best of 2)
      3 99A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-25.36
    cdc-25.26
    (see all 4)
    Protein CDC-25.2 (cdc-25.2) mRNA, complete cds
    (see all 4)
    24(a)
    23(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    III(8916417-8917929) WBGene00000388
    V(1577690-1585472) WBGene00000387
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIH16
    Protein tyrosine phosphatase involved in cell cycl...
    16(a)
    1 → many
    XIII(341856-343520) YMR036C


    ENSEMBL Gene Tree for CDC25B (if available)
    TreeFam Gene Tree for CDC25B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC25B gene
    CDC25A2  CDC25C2  
    3 SIMAP similar genes for CDC25B using alignment to 8 protein entries:     MPIP2_HUMAN (see all proteins):
    DKFZp686G14213    CDC25C    CDC25A

    Find genes that share paralogs with CDC25B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC25B (see all 406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839647931,2
    --3718099(+) CCACCC/TATGAG 3 -- us2k10--------
    rs1889186571,2
    --3718114(+) ATATGC/TGGTGT 3 -- us2k10--------
    rs116988741,2
    C,H--3718122(+) tgtttG/Tgtttt 3 -- us2k1 tfbs31Minor allele frequency- T:0.00NA 2
    rs1930698351,2
    --3718458(+) CACAAG/TGGTTG 3 -- us2k10--------
    rs1846324441,2
    --3718472(+) TAGTTC/TACAGT 3 -- us2k10--------
    rs60520801,2
    C,A,H--3718485(+) CACCAA/GCGGTG 3 -- us2k13Minor allele frequency- G:0.00NA CSA 5
    rs60520811,2
    --3718635(+) catttC/Tttcat 3 -- us2k10--------
    rs1467547401,2
    --3718747(+) GGATAC/GCTGTT 3 -- us2k10--------
    rs342636281,2
    C--3718786(+) GGCAG-/TTTTTTT 3 -- us2k11Minor allele frequency- TT:0.00NA 2
    rs1408343221,2
    --3718883(+) TGGCT-/GGGAGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC25B (3767578 - 3786762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDC25B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912617CNV Loss21882294
    nsv912618CNV Loss21882294
    nsv833899CNV Loss17160897
    dgv4522n71CNV Loss21882294
    nsv912621CNV Loss21882294
    nsv828673CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC25B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116949    OMIM disorders: --


    Find genes that share disorders with CDC25B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDC25B gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 43.3 26 19276368 (3), 16818502 (2), 12801222 (1), 14712212 (1) (see all 20)
    tumors 36.8 39 9563496 (5), 9751615 (4), 10850455 (3), 15193457 (2) (see all 23)
    neoplastic transformation 30.7 1 17361412 (1)
    carcinoma squamous cell 28.7 11 11487274 (2), 11972550 (2), 18722351 (1), 11489794 (1) (see all 7)
    mammary tumor 23.4 2 10498865 (1), 10467401 (1)
    primary tumor 23 5 18722351 (1), 11489794 (1), 17651784 (1), 10467401 (1)
    neck cancer 14.8 3 14769838 (1), 9192810 (1), 9751615 (1)
    breast cancer 7.98 1 7667636 (1)
    nsclc 4.27 17 17651784 (6), 11597794 (4), 9751615 (3)
    colorectal carcinoma 2.01 3 10850455 (2)

    Genetic Association Database (GAD): CDC25B
    Human Genome Epidemiology (HuGE) Navigator: CDC25B (9 documents)
    Tumor Gene Database (TGDB): CDC25B

    Export disorders for CDC25B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CDC25B gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with CDC25B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)1, 2, 3, 9 Galaktionov K.I. and Beach D. (Cell 1991)
    2. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. (PubMed id 15128871)1, 2, 9 Dutertre S.... Ducommun B. (J. Cell Sci. 2004)
    3. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. (PubMed id 15908796)1, 2, 9 Mirey G.... Ducommun B. (Cell Cycle 2005)
    4. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. (PubMed id 12400006)1, 2, 9 Davezac N.... Tassan J.P. (Oncogene 2002)
    5. Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? (PubMed id 9188863)1, 2, 9 Baldin V.... Docommun B. (Oncogene 1997)
    6. Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. (PubMed id 17332740)1, 2, 9 Schmidt A.... Hall A. (EMBO J. 2007)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    8. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (Genet. Epidemiol. 2011)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 994 HGNC: 1726 AceView: CDC25BandC20orf29 Ensembl:ENSG00000101224 euGenes: HUgn994
    ECgene: CDC25B Kegg: 994 H-InvDB: CDC25B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC25B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC25B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC25B gene:
    Search GeneIP for patents involving CDC25B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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