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Aliases for CDC25B Gene

Aliases for CDC25B Gene

  • Cell Division Cycle 25B 2 3
  • EC 3.1.3.48 4 63
  • Cell Division Cycle 25 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 25 Homolog B (S. Pombe) 2
  • Dual Specificity Phosphatase Cdc25B 4
  • CDC25HU2 4

External Ids for CDC25B Gene

Previous GeneCards Identifiers for CDC25B Gene

  • GC20P003765
  • GC20P003724

Summaries for CDC25B Gene

Entrez Gene Summary for CDC25B Gene

  • CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25B Gene

CDC25B (Cell Division Cycle 25B) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and ERK Signaling. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25C.

UniProtKB/Swiss-Prot for CDC25B Gene

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Tocris Summary for CDC25B Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25 activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation, interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex. Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex. Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit mitosis.

Gene Wiki entry for CDC25B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25B Gene

Genomics for CDC25B Gene

Regulatory Elements for CDC25B Gene

Transcription factor binding sites by QIAGEN in the CDC25B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC25B Gene

Start:
3,786,772 bp from pter
End:
3,806,121 bp from pter
Size:
19,350 bases
Orientation:
Plus strand

Genomic View for CDC25B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC25B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25B Gene

Proteins for CDC25B Gene

  • Protein details for CDC25B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30305-MPIP2_HUMAN
    Recommended name:
    M-phase inducer phosphatase 2
    Protein Accession:
    P30305
    Secondary Accessions:
    • D3DVY1
    • D3DVY2
    • D3DVY3
    • D3DVY4
    • O43551
    • Q13971
    • Q5JX77
    • Q6RSS1
    • Q9BRA6

    Protein attributes for CDC25B Gene

    Size:
    580 amino acids
    Molecular mass:
    64987 Da
    Quaternary structure:
    • Interacts with MAPK14 and 14-3-3 proteins.

    Three dimensional structures from OCA and Proteopedia for CDC25B Gene

    Alternative splice isoforms for CDC25B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25B Gene

Proteomics data for CDC25B Gene at MOPED

Selected DME Specific Peptides for CDC25B Gene

Post-translational modifications for CDC25B Gene

  • Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
  • Ubiquitination at Lys71, Lys204, Lys398, and Lys469
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC25B (CDC25B)

Domains for CDC25B Gene

Gene Families for CDC25B Gene

HGNC:
  • PTP3 :Protein tyrosine phosphatases / Class III Cys-based PTPs

Protein Domains for CDC25B Gene

Graphical View of Domain Structure for InterPro Entry

P30305

UniProtKB/Swiss-Prot:

MPIP2_HUMAN :
  • P30305
Domain:
  • Contains 1 rhodanese domain.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25B: view

Function for CDC25B Gene

Molecular function for CDC25B Gene

GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form B,regulator of the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by B-type cyclins
UniProtKB/Swiss-Prot Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Enzyme Numbers (IUBMB) for CDC25B Gene

Gene Ontology (GO) - Molecular Function for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS 9188863
GO:0005515 protein binding IPI 10713667
GO:0019901 protein kinase binding IPI 12400006
genes like me logo Genes that share ontologies with CDC25B: view
genes like me logo Genes that share phenotypes with CDC25B: view

Animal Models for CDC25B Gene

MGI Knock Outs for CDC25B:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC25B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CDC25B Gene

Localization for CDC25B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC25B Gene COMPARTMENTS Subcellular localization image for CDC25B gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 15908796
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDC25B: view

Pathways for CDC25B Gene

genes like me logo Genes that share pathways with CDC25B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS 12400006
GO:0000087 mitotic M phase --
GO:0000278 mitotic cell cycle TAS 9188863
GO:0001556 oocyte maturation IEA --
GO:0006468 protein phosphorylation IDA 17332740
genes like me logo Genes that share ontologies with CDC25B: view

Compounds for CDC25B Gene

(1) Tocris Compounds for CDC25B Gene

Compound Action Cas Number
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor [93718-83-3]

(1) HMDB Compounds for CDC25B Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2

(3) Drugbank Compounds for CDC25B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cysteinesulfonic Acid
target
Double Oxidized Cysteine
target
Methyl Mercury Ion
target

(9) Novoseek inferred chemical compound relationships for CDC25B Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 43.8 1
tyrosine 40.1 7
quinone 39.5 1
hydroxyurea 27.4 3
threonine 26.8 1
genes like me logo Genes that share compounds with CDC25B: view

Transcripts for CDC25B Gene

Unigene Clusters for CDC25B Gene

Cell division cycle 25B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC25B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - -
SP9:
SP10: - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - -
SP14: - - -
SP15:

ExUns: 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:

Relevant External Links for CDC25B Gene

GeneLoc Exon Structure for
CDC25B
ECgene alternative splicing isoforms for
CDC25B

Expression for CDC25B Gene

mRNA expression in normal human tissues for CDC25B Gene

Protein differential expression in normal tissues for CDC25B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC25B Gene

SOURCE GeneReport for Unigene cluster for CDC25B Gene Hs.153752

genes like me logo Genes that share expressions with CDC25B: view

Expression partners for CDC25B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC25B Gene

Orthologs for CDC25B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC25B 35
  • 87.97 (n)
  • 87.97 (a)
CDC25B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC25B 35
  • 85.53 (n)
  • 85.9 (a)
CDC25B 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc25b 35
  • 81.33 (n)
  • 81.57 (a)
Cdc25b 16
Cdc25b 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC25B 35
  • 99.37 (n)
  • 99.31 (a)
CDC25B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc25b 35
  • 81.07 (n)
  • 80.31 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC25B 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC25B 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25b 35
  • 61.78 (n)
  • 54.3 (a)
zebrafish
(Danio rerio)
Actinopterygii cdc25 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stg 37
  • 38 (a)
twe 37
  • 36 (a)
stg 36
  • 29 (a)
ManyToMany
twe 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-25.1 36
  • 19 (a)
ManyToMany
cdc-25.2 36
  • 23 (a)
ManyToMany
cdc-25.3 36
  • 24 (a)
ManyToMany
cdc-25.4 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 36
  • 37 (a)
OneToMany
Species with no ortholog for CDC25B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25B Gene

ENSEMBL:
Gene Tree for CDC25B (if available)
TreeFam:
Gene Tree for CDC25B (if available)

Paralogs for CDC25B Gene

Paralogs for CDC25B Gene

Selected SIMAP similar genes for CDC25B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CDC25B: view

Variants for CDC25B Gene

Sequence variations from dbSNP and Humsavar for CDC25B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3516 -- 3,806,034(-) CCCCC(A/G)TCTTG utr-variant-3-prime
rs8156 -- 3,805,990(+) AAGCA(C/G)CTAAA utr-variant-3-prime
rs514521 -- 3,804,925(-) CGCCG(C/G)CTCCG reference, missense
rs514523 -- 3,804,924(-) GCCGG(C/G/T)TCCGC missense, reference
rs592687 -- 3,803,002(-) CAAAT(C/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC25B Gene

Variant ID Type Subtype PubMed ID
nsv833899 CNV Loss 17160897
nsv912617 CNV Loss 21882294
nsv828673 CNV Gain 20364138
nsv912618 CNV Loss 21882294
dgv4522n71 CNV Loss 21882294
nsv912621 CNV Loss 21882294

Relevant External Links for CDC25B Gene

HapMap Linkage Disequilibrium report
CDC25B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25B Gene

Disorders for CDC25B Gene

(18) Novoseek inferred disease relationships for CDC25B Gene

Disease -log(P) Hits PubMed IDs
cancer 43.3 23
tumors 36.8 34
neoplastic transformation 30.7 1
carcinoma squamous cell 28.7 9
mammary tumor 23.4 2

Relevant External Links for CDC25B

Genetic Association Database (GAD)
CDC25B
Human Genome Epidemiology (HuGE) Navigator
CDC25B
Tumor Gene Database (TGDB):
CDC25B
genes like me logo Genes that share disorders with CDC25B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CDC25B Gene

Publications for CDC25B Gene

  1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PMID: 1836978) Galaktionov K.I. … Beach D. (Cell 1991) 2 3 4 23
  2. Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? (PMID: 9188863) Baldin V. … Docommun B. (Oncogene 1997) 3 4 23
  3. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. (PMID: 12400006) Davezac N. … Tassan J.P. (Oncogene 2002) 3 4 23
  4. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. (PMID: 15908796) Mirey G. … Ducommun B. (Cell Cycle 2005) 3 4 23
  5. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. (PMID: 15128871) Dutertre S. … Ducommun B. (J. Cell Sci. 2004) 3 4 23

Products for CDC25B Gene

Sources for CDC25B Gene

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