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CDC25B Gene

protein-coding   GIFtS: 67

GC20P003771
cell division cycle 25 homolog B (S. pombe)
(Previous names: cell division cycle 25B, cell division cycle 25 homolog B (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for CDC25B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
cell division cycle 25 homolog B (S. pombe)1 2     M-phase inducer phosphatase 22
cell division cycle 25B1 2     CDC25HU23
Dual specificity phosphatase Cdc25B2 3     EC 3.1.3.483
cell division cycle 25 homolog B (S. cerevisiae)1     

External Ids:    HGNC: 17261   Entrez Gene: 9942   Ensembl: ENSG000001012247   UniProtKB: P303053   

Search outside databases for aliases for CDC25B gene

Previous GC identifers: GC20P003765 GC20P003724

Summaries
for CDC25B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for CDC25B:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing
two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm
due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell
cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor
formation has not been determined. Multiple transcript variants for this gene exist. (provided by RefSeq)

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly
dephosphorylates CDC2 and stimulates its kinase activity. The three isoforms seem to have a different level of
activity

"" summary for CDC25B:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25B

Genomic Views
for CDC25B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the CDC25B gene upstream (promoter) region "":
GR-beta   GR-alpha   POU2F2C   oct-B2   Oct-B1   POU2F1   oct-B3   POU2F2B   POU2F2   POU2F2 (Oct-2.1)   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CDC25B:  ""
MePH25490-2A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CDC25B Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003771:  view genomic region     (about GC identifiers)

Start:
 3,776,386 bp from pter
End:
 3,786,762 bp from pter
Size:
 10,377 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  

Proteins
for CDC25B gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 2  
Size: 580 amino acids; 64987 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome
PDB structures from "" and Proteopedia "" :
1CWR (3D) ""    1CWS (3D) ""    1CWT (3D) ""    1QB0 (3D) ""    1YM9 (3D) ""    1YMD (3D) ""    1YMK (3D) ""    1YML (3D) ""    
1YS0 (3D) ""    2A2K (3D) ""    2IFD (3D) ""    2IFV (3D) ""    2UZQ (3D) ""    3FQT (3D) ""    3FQU (3D) ""    
Secondary accessions: O43551 Q13971 Q5JX77 Q6RSS1 Q9BRA6
Alternative splicing: 4 isoforms:  P30305-1   P30305-2   P30305-3   P30305-4   

Post-translational modifications:

  • Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_004349.1  NP_068658.1  NP_068659.1  


    ENSEMBL proteins: 
    ENSP00000339125 ENSP00000368918 ENSP00000245960 ENSP00000339170 ENSP00000405972 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant CDC25B Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    ""R&D Systems Recombinant & Natural Proteins for CDC25B
    ""Enzo Life Sciences proteins for CDC25B
    ""HuPro® and/or Recombinant Proteins from Abnova for CDC25B ""
    "" Origene Purified Recombinant Human Proteins (see all 2): CDC25B
    ""Novus Biologicals Proteins for CDC25B  ""
    Novus Biologicals Lysates for CDC25B
    ""Browse Sino Biological Recombinant Proteins  ""

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular NAS--
    GO:0005654 nucleoplasm EXP1828290 15456846
    GO:0005737 cytoplasm IEA--
    GO:0005813 centrosome ----
    GO:0005815 microtubule organizing center IEA--
    About this table

    "" CDC25B for ontologies           About GeneDecksing



    Antibodies for CDC25B: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for CDC25B
    ""R&D Systems Antibodies for CDC25B
    ""Cell Signaling Technology (CST) Antibodies for CDC25B 
    ""Monoclonal and Polyclonal Antibodies from Abnova (CDC25B)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for CDC25B
    ""Browse antibodies at Epitomics

    Assays for CDC25B: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for CDC25B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" CDC25B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001763 Rhodanese-like
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30305

    ProtoNet protein and cluster: P30305

    2 Blocks protein families:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain

    Gene Function
    for CDC25B gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CDC25B)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): CDC25B
    Origene shRNA RFP (see all 4): CDC25B
    Origene basic RS shRNA (see all 4): CDC25B

    ""Applied Biosystems Silencer® siRNAs for CDC25B
    ""Sigma-Aldrich siRNA Panels and siRNA for CDC25B
    Sigma-Aldrich shRNA Panels and shRNA for CDC25B
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC25B
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC25B
    Origene untagged cDNA clones in CMV expression vector (see all 3): CDC25B
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305
    Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly
    dephosphorylates CDC2 and stimulates its kinase activity. The three isoforms seem to have a different level of
    activity
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Stimulated by B-type cyclins
    Enzyme Number (IUBMB): EC 3.1.3.48 

    Genatlas biochemistry entry for CDC25B:
    cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form
    B,regulator of the cell cycle

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721 phosphoprotein phosphatase activity EXP1828290
    GO:0004725 protein tyrosine phosphatase activity TAS9188863
    GO:0005515 protein binding IPI7644510 17353931
    GO:0016787 hydrolase activity IEA--
    About this table

    "" CDC25B for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 1 allele"") (MGI details for Cdc25b):

    digestive/alimentaryendocrine/exocrine glandgrowth/sizelife span-post-weaning/agingreproductive system

    "" CDC25B for phenotypes           About GeneDecksing

    Pathways & Interactions
    for CDC25B gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" CDC25B for pathways           About GeneDecksing

    2 "" Millipore Pathways for CDC25B
      ""  Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Cell cycle (generic schema)

    3 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  CDC25B  (Your Favorite Gene powered by Ingenuity)
      ""  Molecular Mechanisms of Cancer
    Mitotic Roles of Polo-Like Kinase
    Cell Cycle: G2/M DNA Damage Checkpoint Regulation

    2 "" GeneAssist Pathways for CDC25B
      ""  14-3-3 and Cell Cycle Regulation
    Molecular Mechanisms of Cancer

    3 "" Kegg Pathways  (Kegg details for CDC25B):
      ""  hsa04010 MAPK signaling pathway
    hsa04110 Cell cycle
    hsa04914 Progesterone-mediated oocyte maturation

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC25B

    5/28 Interacting proteins for CDC25B (P303051, 2 ENSP000002459603) via UniProtKB, MINT, and/or STRING (see all 28 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319461, 2, ENSP000003619303EBI-1051746,EBI-359815 MINT-19327 MINT-51064 MINT-51065 MINT-25122 EBI-1051746,EBI-359815 MINT-19327 MINT-51064 MINT-51065 MINT-25122 STRING: ENSP00000361930
    YWHAEP622581, 2, ENSP000002643353EBI-1051746,EBI-356498 MINT-51066 MINT-25123 MINT-51067 EBI-1051746,EBI-356498 MINT-51066 MINT-25123 MINT-51067 STRING: ENSP00000264335
    YWHAZP631042, ENSP000003095033MINT-19329 MINT-17849 MINT-17850 MINT-25121 STRING: ENSP00000309503
    YWHAHQ049172, ENSP000002489753MINT-25118 MINT-19328 MINT-19330 STRING: ENSP00000248975
    SFNP319472, ENSP000003409893MINT-51068 MINT-51069 MINT-51070 STRING: ENSP00000340989
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087 M phase of mitotic cell cycle ----
    GO:0000278 mitotic cell cycle TAS9188863
    GO:0001556 oocyte maturation ----
    GO:0006470 protein amino acid dephosphorylation IEA--
    GO:0007067 mitosis IEA--
    About this table

    "" CDC25B for ontologies           About GeneDecksing


    Drugs & Compounds
    for CDC25B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" CDC25B for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for CDC25B
    ""Sigma-Aldrich Small Molecules for CDC25B:
    Small Molecule - Inhibitor

    "" Compounds for CDC25B available from Tocris Bioscience
    CompoundAction CAS number
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]
    NSC 663284Potent, selective Cdc25 phosphatase inhibitor[383907-43-5]
    About this table


    10/48 ""Novoseek chemical compound relationships for CDC25B gene (see all 48 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bpde 13.58 9 17909020 (5), 12591724 (3), 17630511 (1)
    sparc 5.92 4 17187659 (4)
    arsenite 3.62 5 20025242 (3), 16645841 (2)
    dnacin b1 3.42 1 7802705 (1)
    halenaquinone 3.23 1 15670907 (1)
    questin 3.21 1 17497420 (1)
    xestoquinone 2.59 1 15670907 (1)
    p-nitrophenyl phosphate 2.53 2 7802705 (1), 19301836 (1)
    anisomycin 2.49 2 19638579 (2)
    rapamycin 2.33 5 19276368 (5)
    About this table


    Transcripts
    for CDC25B gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (CDC25B)
    ""Applied Biosystems Silencer® siRNAs:  NM_004358  NM_021872  NM_021873  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): CDC25B
    Origene shRNA RFP (see all 4): CDC25B
    Origene basic RS shRNA (see all 4): CDC25B

    ""Sigma-Aldrich siRNA Panels and siRNA for CDC25B
    Sigma-Aldrich shRNA Panels and shRNA for CDC25B
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""7 SABiosciences microRNAs that regulate CDC25B: ""
    hsa-miR-152 hsa-miR-148b hsa-miR-188-5p hsa-miR-27a hsa-miR-27b hsa-miR-148a hsa-miR-211
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_004358  NM_021872  NM_021873  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC25B
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC25B
    Origene untagged cDNA clones in CMV expression vector (see all 3): CDC25B
    Primers:"" Origene genome-wide validated SYBR primer pairs: CDC25B
    ""SABiosciences RT2 qPCR Primer Assay for CDC25B: PPH01353A ""

    REFSEQ mRNAs for CDC25B gene (3 alternative transcripts): 

    NM_004358.3  NM_021872.2  NM_021873.2  

    Additional cDNA sequence: 

    AK092713.1 AK295573.1 AK299028.1 AK299192.1 BC006395.2 BC009953.2 BC051711.1 BX640836.1 
    BX647988.1 CR591656.1 CR615304.1 CR620818.1 CR621743.1 M81934.1 S78187.1 Z68092.1 

    24/29 DOTS entries (see all 29 ):

    DT.452676  DT.100812620  DT.100812628  DT.95244406  DT.101983619  DT.100812618  DT.100724666  DT.95244417 
    DT.100801781  DT.97859977  DT.100812626  DT.40116000  DT.100038305  DT.100812622  DT.95214264  DT.102822230 
    DT.120819392  DT.75117755  DT.95183579  DT.95244409  DT.100703642  DT.100738683  DT.120819356  DT.120819360 

    24/474 AceView cDNA sequences (see all 474 ):

    BE676643 BU528842 BC043344 BU621584 BM795308 BQ941163 BM853477 AI870482 
    AA448659 BU557762 BM854174 BQ962413 AI953408 CB125501 CR621743 CD671180 
    BI906779 BQ962034 CB044907 H42408 CD671179 CN484019 BU507591 BF512205 

    "" highest scoring ESTs for CDC25B:

    S78187 AA102013 AA306789 AA310302 AA311345 AA352638 AA357400 AA402262 AA448755 AA514594 

    Unigene Cluster for CDC25B:

    Cell division cycle 25 homolog B (S. pombe)
    Hs.153752  [show with all ESTs]
    Unigene Representative Sequence: NM_021873


    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B (see all 15 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ·
    SP1:                    -     -     -     -     -                 -           -     -                 -                                         -     -         
    SP2:                    -     -     -     -     -     -           -           -     -                 -                                         -     -         
    SP3:                                            -                 -           -     -                 -                                         -     -         
    SP4:                                            -     -           -           -     -                 -                                         -     -         
    SP5:                                            -                 -           -     -                 -     -     -                             -     -         

    ExUns: 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                    -                                                   
    SP2:                    -                                                   
    SP3:                    -                                                   
    SP4:                    -                                                   
    SP5:                    -                                                   

    About this scheme

    ECgene alternative splicing isoforms for CDC25B

    9 Ensembl transcripts including schematic representations:
    ENST00000344256  ENST00000379598  ENST00000468979  ENST00000480816  ENST00000495915  ENST00000245960  
    ENST00000340833  ENST00000439880  ENST00000467519  

    Expression
    for CDC25B gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    CDC25B expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for CDC25B

    1""  / 2""  / 3""

    3 probe-sets matching CDC25B gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1347_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 S78187 1.00 1.00 1.00 1
    201853_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021873 0.60 1.00 0.82 1
    201853_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" CDC25B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACAGCCTGCA

    SOURCE GeneReport for Unigene cluster: Hs.153752

    Expression variation in blood from EXPOLDB for CDC25B

    Primers:"" Origene genome-wide validated SYBR primer pairs: CDC25B ""
    ""SABiosciences RT2 qPCR Primer Assay for CDC25B: PPH01353A ""

    Orthologs
    for CDC25B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for CDC25B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CDC25B1   -- cell division cycle 25 homolog B (S. pombe) 86.45(n)
    86.39(a)    		 485790  XM_845093.1  XP_850186.1 
    chimpanzee
    (Pan troglodytes)    		 CDC25B1   -- cell division cycle 25 homolog B (S. pombe) 99.37(n)
    99.31(a)    		 458064  XM_001162706.1  XP_001162706.1 
    cow
    (Bos taurus)    		 CDC25B1   -- cell division cycle 25 homolog B (S. pombe) 87.78(n)
    87.78(a)    		 505847  XM_866334.2  XP_871427.1 
    rat
    (Rattus norvegicus)    		 Cdc25b1   -- cell division cycle 25 homolog B (S. pombe) 81.36(n)
    80.66(a)    		 171103  NM_133572.1  NP_598256.1 
    mouse
    (Mus musculus)    		 Cdc25b1, 5 2 (73.90 cM)5
    		 cell division cycle 25 homolog B (S. pombe)1, 5 81.8(n)1
    81.91(a)1    		 125311  NM_023117.11  NP_075606.11 
     AA0003255  AA2593065  (see all 23)
    About this table        Species with no ortholog for CDC25B

    ENSEMBL Gene Tree for CDC25B

    Paralogs
    for CDC25B gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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    Paralogs for CDC25B gene
    CDC25A2  CDC25C2  

    "" CDC25B for paralogs           About GeneDecksing


    Genomic Variants
    for CDC25B gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/165 NCBI SNPs in CDC25B are shown (see all 165 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 45)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs61160421,2
    		C,F,A,H3776968(+) TTCCCA/TGGCTG 3 -- ut51 ese3""13Minor allele frequency- T:0.26NS EA NA 1038""
    ""
    rs37612181,2
    		C,F,A,H3724760(+) TTCGCT/CTCTCT 3 -- ng51""26Minor allele frequency- C:0.32EA NS NA WA 3534""
    --
    rs60520801,2
    		C,A,H3723451(+) caccaA/Gcggtg 3 -- ng51""1Minor allele frequency- G:0.00NA 2""
    ""
    rs37612191,2
    		C,F,A3724953(+) GCGCTC/TCTCCT 3 -- ng51""15Minor allele frequency- T:0.30EA NS NA WA 2416""
    --
    rs37612201,2
    		C,F,A3724985(+) CTCAGC/GGCAGC 3 -- ng51 ese3""11Minor allele frequency- G:0.22NS NA 912""
    --
    rs20771511,2
    		C,F,H3735433(-) CTGTCC/TCCTAC 3 -- ng31""6Minor allele frequency- T:0.48NS NA EA 336""
    ""
    rs115700201,2
    		C,F,H3785819(+) AGAGCC/TCAGTC 3 -- ut31 ese3""5Minor allele frequency- T:0.01NS EA 582""
    --
    rs18032631,2
    		C,F,A3786567(+) GTGTGC/TCTATT 3 -- ut31 ese3""8Minor allele frequency- T:0.10NS WA 696""
    ""
    rs115700211,2
    		C,F,H3786106(+) GTTGCC/TCCTTT 3 -- ut31 trp3""11Minor allele frequency- T:0.00NS EA 1058""
    ""
    rs81561,2
    		C,F,A3786637(+) AAGCAG/CCTAAA 3 -- ut31 ese3""14Minor allele frequency- C:0.03NS MN EA NA 1400""
    About this table

    HapMap Linkage Disequilibrium images for CDC25B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for CDC25B: --

    Disorders & Mutations
    for CDC25B gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" CDC25B for disorders           About GeneDecksing

    OMIM: 116949

    10/52 ""Novoseek disease relationships for CDC25B gene (see all 52 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    escc 39.22 26 18559558 (6), 18722351 (5), 17187659 (4), 11489794 (4) (see all 7)
    nsclc 9.70 15 17651784 (7), 11597794 (5), 9751615 (3)
    genomic instabilities 5.55 5 1844245 (2), 20128929 (1), 19075565 (1), 18089784 (1)
    cytoplasmic accumulation 3.60 2 8743955 (1), 14630392 (1)
    neoplastic transformation 2.99 3 17909020 (2), 17361412 (1)
    follicular carcinoma, widely invasive 2.84 1 12085185 (1)
    laryngeal squamous cell carcinoma 2.42 2 18551998 (2)
    cellular stress 2.37 2 20176018 (1), 15456846 (1)
    follicular carcinoma, minimally invasive 2.34 1 12085185 (1)
    esophageal cancer 2.33 5 11156245 (3), 11306507 (2)
    About this table

    Human Genome Epidemiology Navigator: CDC25B (6 documents)
    Tumor Gene Database: CDC25B

    Medical News
    for CDC25B gene

    (Possibly Related Articles in Doctor's Guide)
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      User Feedback    		   --

    Publications
    for CDC25B gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/166 PubMed articles for CDC25B gene (see all 166 ):

    Search for CDC25B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDC25B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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      User Feedback
    Entrez Gene: 994 HGNC: 1726 AceView: CDC25BandC20orf29 Ensembl:ENSG00000101224 euGenes: HUgn994
    ECgene: CDC25B Kegg: 994 H-InvDB: CDC25B

    Other Databases showing CDC25B gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing CDC25B gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for CDC25B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25b/

    Intellectual Property
    for CDC25B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for CDC25B gene: ""
    Search GeneIP for patents involving CDC25B

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for CDC25B gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    ""
    Products for CDC25B:
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