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Aliases for CDC25B Gene

Aliases for CDC25B Gene

  • Cell Division Cycle 25B 2 3 5
  • EC 3.1.3.48 4 63
  • Cell Division Cycle 25 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 25 Homolog B (S. Pombe) 2
  • Dual Specificity Phosphatase Cdc25B 4
  • CDC25HU2 4

External Ids for CDC25B Gene

Previous GeneCards Identifiers for CDC25B Gene

  • GC20P003765
  • GC20P003724

Summaries for CDC25B Gene

Entrez Gene Summary for CDC25B Gene

  • CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25B Gene

CDC25B (Cell Division Cycle 25B) is a Protein Coding gene. Diseases associated with CDC25B include breast cancer and esophageal cancer. Among its related pathways are Cell Cycle, Mitotic and MicroRNAs in cancer. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25C.

UniProtKB/Swiss-Prot for CDC25B Gene

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Tocris Summary for CDC25B Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression.

Gene Wiki entry for CDC25B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25B Gene

Genomics for CDC25B Gene

Regulatory Elements for CDC25B Gene

Promoters for CDC25B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC25B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDC25B gene promoter:

Genomic Location for CDC25B Gene

Chromosome:
20
Start:
3,786,772 bp from pter
End:
3,806,121 bp from pter
Size:
19,350 bases
Orientation:
Plus strand

Genomic View for CDC25B Gene

Genes around CDC25B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC25B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC25B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25B Gene

Proteins for CDC25B Gene

  • Protein details for CDC25B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30305-MPIP2_HUMAN
    Recommended name:
    M-phase inducer phosphatase 2
    Protein Accession:
    P30305
    Secondary Accessions:
    • D3DVY1
    • D3DVY2
    • D3DVY3
    • D3DVY4
    • O43551
    • Q13971
    • Q5JX77
    • Q6RSS1
    • Q9BRA6

    Protein attributes for CDC25B Gene

    Size:
    580 amino acids
    Molecular mass:
    64987 Da
    Quaternary structure:
    • Interacts with MAPK14 and 14-3-3 proteins.

    Three dimensional structures from OCA and Proteopedia for CDC25B Gene

    Alternative splice isoforms for CDC25B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC25B Gene

Proteomics data for CDC25B Gene at MOPED

Selected DME Specific Peptides for CDC25B Gene

Post-translational modifications for CDC25B Gene

  • Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
  • Ubiquitination at Lys 71, Lys 204, Lys 398, and Lys 469
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC25B (CDC25B)

Domains & Families for CDC25B Gene

Gene Families for CDC25B Gene

Protein Domains for CDC25B Gene

Graphical View of Domain Structure for InterPro Entry

P30305

UniProtKB/Swiss-Prot:

MPIP2_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the MPI phosphatase family.
Domain:
  • Contains 1 rhodanese domain.
Family:
  • Belongs to the MPI phosphatase family.
genes like me logo Genes that share domains with CDC25B: view

Function for CDC25B Gene

Molecular function for CDC25B Gene

GENATLAS Biochemistry:
cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form B,regulator of the cell cycle
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by B-type cyclins.
UniProtKB/Swiss-Prot Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Enzyme Numbers (IUBMB) for CDC25B Gene

Gene Ontology (GO) - Molecular Function for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7644510
genes like me logo Genes that share ontologies with CDC25B: view
genes like me logo Genes that share phenotypes with CDC25B: view

Animal Models for CDC25B Gene

MGI Knock Outs for CDC25B:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDC25B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC25B Gene

Localization for CDC25B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC25B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC25B Gene COMPARTMENTS Subcellular localization image for CDC25B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with CDC25B: view

Pathways & Interactions for CDC25B Gene

genes like me logo Genes that share pathways with CDC25B: view

SIGNOR curated interactions for CDC25B Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDC25B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000087 mitotic M phase IEA --
GO:0000278 mitotic cell cycle TAS 9188863
GO:0001556 oocyte maturation IEA --
GO:0006468 protein phosphorylation IDA 17332740
GO:0008284 positive regulation of cell proliferation TAS 8276402
genes like me logo Genes that share ontologies with CDC25B: view

Drugs & Compounds for CDC25B Gene

(8) Drugs for CDC25B Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteinesulfonic Acid Experimental Pharma Target 0
Double Oxidized Cysteine Experimental Pharma Target 0
Methyl Mercury Ion Experimental Pharma Target 0

(9) Additional Compounds for CDC25B Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
NSC 663284
383907-43-5
NSC 95397
93718-83-3
genes like me logo Genes that share compounds with CDC25B: view

Transcripts for CDC25B Gene

Unigene Clusters for CDC25B Gene

Cell division cycle 25B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - -
SP9:
SP10: - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - -
SP14: - - -
SP15:

ExUns: 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:

Relevant External Links for CDC25B Gene

GeneLoc Exon Structure for
CDC25B
ECgene alternative splicing isoforms for
CDC25B

Expression for CDC25B Gene

mRNA expression in normal human tissues for CDC25B Gene

Protein differential expression in normal tissues from HIPED for CDC25B Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC25B Gene



SOURCE GeneReport for Unigene cluster for CDC25B Gene Hs.153752

genes like me logo Genes that share expression patterns with CDC25B: view

Protein tissue co-expression partners for CDC25B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC25B Gene

Orthologs for CDC25B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC25B 35
  • 87.97 (n)
  • 87.97 (a)
CDC25B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC25B 35
  • 85.53 (n)
  • 85.9 (a)
CDC25B 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc25b 35
  • 81.33 (n)
  • 81.57 (a)
Cdc25b 16
Cdc25b 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC25B 35
  • 99.37 (n)
  • 99.31 (a)
CDC25B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc25b 35
  • 81.07 (n)
  • 80.31 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC25B 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC25B 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25b 35
  • 61.78 (n)
  • 54.3 (a)
zebrafish
(Danio rerio)
Actinopterygii cdc25 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stg 37
  • 38 (a)
twe 37
  • 36 (a)
stg 36
  • 29 (a)
ManyToMany
twe 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-25.1 36
  • 19 (a)
ManyToMany
cdc-25.2 36
  • 23 (a)
ManyToMany
cdc-25.3 36
  • 24 (a)
ManyToMany
cdc-25.4 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 36
  • 37 (a)
OneToMany
Species with no ortholog for CDC25B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25B Gene

ENSEMBL:
Gene Tree for CDC25B (if available)
TreeFam:
Gene Tree for CDC25B (if available)

Paralogs for CDC25B Gene

Paralogs for CDC25B Gene

(3) SIMAP similar genes for CDC25B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CDC25B: view

Variants for CDC25B Gene

Sequence variations from dbSNP and Humsavar for CDC25B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11570019 - 3,804,860(+) ACCAC(A/G)AGGCC nc-transcript-variant, reference, missense
rs3516 -- 3,806,034(-) CCCCC(A/G)TCTTG utr-variant-3-prime
rs8156 -- 3,805,990(+) AAGCA(C/G)CTAAA utr-variant-3-prime
rs932529 -- 3,798,982(-) CCTTG(A/C/G/T)AGAAA intron-variant, upstream-variant-2KB
rs514521 -- 3,804,925(-) CGCCG(C/G)CTCCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDC25B Gene

Variant ID Type Subtype PubMed ID
nsv833899 CNV Loss 17160897
nsv912617 CNV Loss 21882294
nsv828673 CNV Gain 20364138
nsv912618 CNV Loss 21882294
dgv4522n71 CNV Loss 21882294
nsv912621 CNV Loss 21882294

Variation tolerance for CDC25B Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC25B Gene

HapMap Linkage Disequilibrium report
CDC25B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC25B Gene

Disorders for CDC25B Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDC25B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDC25B

Genetic Association Database (GAD)
CDC25B
Human Genome Epidemiology (HuGE) Navigator
CDC25B
Tumor Gene Database (TGDB):
CDC25B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC25B
genes like me logo Genes that share disorders with CDC25B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC25B Gene

Publications for CDC25B Gene

  1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PMID: 1836978) Galaktionov K.I. … Beach D. (Cell 1991) 2 3 4 23 67
  2. Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases. (PMID: 20025242) Bhattacharjee H. … Rosen B.P. (Biochemistry 2010) 3 23
  3. Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage. (PMID: 20128929) Bugler B. … Ducommun B. (Mol. Cancer 2010) 3 23
  4. UV-induced downregulation of the CDC25B protein in human cells. (PMID: 20176018) Lemaire M. … Nebreda A.R. (FEBS Lett. 2010) 3 23
  5. Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation. (PMID: 19638579) Uchida S. … Yamashita K. (Cancer Res. 2009) 3 23

Products for CDC25B Gene

Sources for CDC25B Gene

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