Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC25A Gene

protein-coding GIFtS: 72
GCID: GC03M048173

cell division cycle 25A

(Previous names: cell division cycle 25A, cell division cycle 25 homolog...)

Explore 53 diseases affiliated with
CDC25A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 25A¹ ²		Cell Division Cycle 25 Homolog A (S. Pombe)¹
Dual Specificity Phosphatase Cdc25A² ³		CDC25A2²
EC 3.1.3.48³ ⁸		CDC25A2-CAG Isoform²
Cell Division Cycle 25 Homolog A (S. Cerevisiae)¹		M-Phase Inducer Phosphatase 1²

External Ids:	HGNC: 1725¹	Entrez Gene: 993²	Ensembl: ENSG00000164045⁷	OMIM: 116947⁵	UniProtKB: P30304³

Export aliases for CDC25A gene to outside databases

Previous GC identifers: GC03P048003 GC03M047482 GC03M048019 GC03M048160 GC03M048159

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC25A:

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of

the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically

degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell

division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly

dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in

vitro

summary for CDC25A:

Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25

activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA

damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,

interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated

and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further

phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is

also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.

Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.

Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit

mitosis.

Gene Wiki entry for CDC25A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC25A gene promoter:
CREB Sp1 deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC25A promoter sequence

Search SABiosciences Chromatin IP Primers for CDC25A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC25A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

CDC25A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25A gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M048173: view genomic region (about GC identifiers)

Start:	48,198,636 bp from pter	End:	48,229,892 bp from pter
Size:	31,257 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304 (See protein sequence)

Recommended Name: M-phase inducer phosphatase 1

Size: 524 amino acids; 59087 Da

Subunit: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1

specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1,

BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A

phosphorylation and degradation in response to infrared-induced DNA damages

1 PDB 3D structure from and Proteopedia for CDC25A:

1C25 (3D)

Secondary accessions: Q8IZH5 Q96IL3 Q9H2F2

Alternative splicing: 2 isoforms: P30304-1 P30304-2

Explore the universe of human proteins at neXtProt for CDC25A: NX_P30304

Post-translational modifications:

Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle

arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest.

Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A.

Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of

CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at

Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and

degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following

DNA damage, leading to promote its ubiquitination and degradation¹

Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1

during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and

FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its

stabilization¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30304

4/7 DME Specific Peptides for CDC25A (P30304) (see all 7)

GGHIKGA

FHCEFSS

GKHQDLKY

LKGGYKEFF

CDC25A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001780.2 NP_963861.1

ENSEMBL proteins:

ENSP00000303706 ENSP00000343166 ENSP00000416483 ENSP00000404285

Reactome Protein details: P30304
Human Recombinant Protein Products for CDC25A:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDC25A
	OriGene Purified Protein: CDC25A Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CDC25A
	GenScript Custom Purified and Recombinant Proteins Services for CDC25A
	Novus Biologicals CDC25A Proteins Novus Biologicals CDC25A Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CDC25A
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

CDC25A for ontologies About GeneDecksing

CDC25A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC25A
	R&D Systems Antibodies for CDC25A
	Cell Signaling Technology (CST) Antibodies for CDC25A
	OriGene Antibodies (see all 2): CDC25A OriGene Custom Antibody Services for CDC25A
	GenScript Superior Antibodies for CDC25A
	Novus Biologicals CDC25A Antibodies
	Abcam antibodies for CDC25A
	Browse Antibodies at Uscn
	ThermoFisher Antibody for CDC25A

Assay Products for CDC25A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC25A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC25A for domains About GeneDecksing

2 InterPro domains/families:

IPR001763 Rhodanese-like_dom

IPR000751 MPI_Phosphatase

Graphical View of Domain Structure for InterPro Entry P30304

ProtoNet protein and cluster: P30304

2 Blocks protein families:

IPB000751 M-phase inducer phosphatase signature

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304

Domain: The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative

phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction

Similarity: Belongs to the MPI phosphatase family

Similarity: Contains 1 rhodanese domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MPIP1_HUMAN, P30304

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly

dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in

vitro

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Enzyme regulation: Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation

Genatlas biochemistry entry for CDC25A:

cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form

A,regulator of the cell cycle,putative up-regulated c-Myc target gene,

Enzyme Number (IUBMB): EC 3.1.3.48¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	--	--
GO:0004725	protein tyrosine phosphatase activity	IEA	--
GO:0005515	protein binding	IPI	7644510
GO:0019901	protein kinase binding	IPI	--

CDC25A for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for CDC25A:

Decreased focal adhesion (FA)

Increased Erk phosphorylation

Increased cell death in breast

Upregulation of Wnt/beta-caten

11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdc25a):

cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	mortality/aging	normal	skeleton
tumorigenesis

CDC25A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CDC25A: Cdc25a^tm1.1Hpw Cdc25a^tm1Kiyo

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDC25A

miRNA Products:		miRTarBase miRNAs that target CDC25A: hsa-mir-34a (MIRT001011), hsa-mir-503 (MIRT000648), hsa-let-7b (MIRT002296), hsa-mir-424 (MIRT000655), hsa-mir-15a (MIRT000284), hsa-mir-449a (MIRT003186), hsa-mir-21 (MIRT000157)

		OriGene 3'-UTR Clone (see all 2): CDC25A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC25A
		8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC25A (see all 70):
		hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CDC25A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC25A (see all 7) OriGene shRNA RFP: CDC25A OriGene siRNA: CDC25A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC25A
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDC25A

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CDC25A
			Sirion Biotech Customized adenovirus for overexpression of CDC25A Sirion Biotech Customized adenovirus for potent knockdown of CDC25A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
		Sino Biological Human cDNA Clone for CDC25A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC25A
		Search LifeMap BioReagents cell lines for CDC25A
		Sirion Biotech Customized stable knockdown cell line services for CDC25A Sirion Biotech Customized inducible knockdown cell line services for CDC25A Sirion Biotech Customized stable overexpressing cell line services for CDC25A Sirion Biotech Customized inducible overexpressing cell line services for CDC25A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/9 pathways (see all 9)
Proteolytic degradation of ubiquitinated-Cdc25A	0.96	Cyclin E associated events during G1/S transition	0.67
p53-Independent DNA Damage Response	0.91	Cyclin A:Cdk2-associated events at S phase entry	0.66
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	0.91	Cell Cycle Checkpoints	0.42
p53-Independent G1/S DNA damage checkpoint	0.91	S Phase	0.40

Cell cycle_Cell cycle (generic schema)

	Cell cycle_Cell cycle (generic schema)	1.00			G0 and Early G1	0.31
	Cell cycle Cell cycle (generic schema)	1.00

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for CDC25A (see all 8)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	Cell cycle ESR1 regulation of G1/S transition

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC25A (see all 7)

	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry
	ATM Pathway
	Cyclins and Cell Cycle Regulation
	STAT3 Pathway

2 Cell Signaling Technology (CST) Pathways for CDC25A

	Phosphatases
	Cell Cycle / Checkpoint Control

5/8 GeneGo (Thomson Reuters) Pathways for CDC25A (see all 8)

	Cell cycle Role of APC in cell cycle regulation
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Cell cycle ESR1 regulation of G1/S transition
	Cell cycle Regulation of G1/S transition (part 1)

5/9 BioSystems Pathways for CDC25A (see all 9)

	miRNAs involved in DDR
	Integrated Breast Cancer Pathway
	Cell cycle
	DNA damage response
	G1 to S cell cycle control

5/27 Reactome Pathways for CDC25A (see all 27)

	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	Proteolytic degradation of ubiquitinated-Cdc25A
	E2F-enabled inhibition of pre-replication complex formation

2 Kegg Pathways (Kegg details for CDC25A):

	Cell cycle
	Progesterone-mediated oocyte maturation

CDC25A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC25A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/141 Interacting proteins for CDC25A (P30304^{1, 2, 3} ENSP00000303706⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 141)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BTRC	Q9Y297²^,³, ENSP00000359206⁴	MINT-49914 MINT-49900 MINT-49902 I2D: score=5 STRING: ENSP00000359206
YWHAE	P62258²^,³, ENSP00000264335⁴	MINT-19304 MINT-19397 MINT-19303 I2D: score=5 STRING: ENSP00000264335
CHEK2	O96017²^,³, ENSP00000372023⁴	MINT-17354 MINT-15591 I2D: score=4 STRING: ENSP00000372023
CDK2	P24941²^,³, ENSP00000266970⁴	MINT-8219811 I2D: score=4 STRING: ENSP00000266970
DUSP8	Q13202²^,³, ENSP00000329539⁴	MINT-8250767 I2D: score=2 STRING: ENSP00000329539

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	11139144
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--

CDC25A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC25A for compounds About GeneDecksing

EMD Millipore small molecules for CDC25A:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for CDC25A

Compounds for CDC25A available from Tocris Bioscience About this table

Compound	Action	CAS #
NSC 95397	Selective Cdc25 dual specificity phosphatase inhibitor	[93718-83-3]
NSC 663284	Potent, selective Cdc25 phosphatase inhibitor	[383907-43-5]

2 HMDB Compounds for CDC25A About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/29 Novoseek chemical compound relationships for CDC25A gene (see all 29) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
benzamide riboside	70	2	11966440 (1), 10467347 (1)
se-methylselenocysteine	52.5	2	15213307 (1), 16518418 (1)
tyrosine	50.4	24	9989807 (3), 12679193 (1), 16809424 (1), 15209522 (1) (see all 22)
camptothecin	46.7	3	16928871 (2), 12676925 (1)
threonine	39.6	3	11804965 (1), 19075567 (1), 20368335 (1)
artesunate	39.2	1	12869643 (1)
arsenite	34.9	7	17545210 (6)
roscovitine	33.3	2	11752153 (1), 12801928 (1)
bpde	33.2	3	16912045 (2), 17602818 (1)
fudr	27.5	9	15374972 (4), 16931916 (2)

Search CenterWatch for drugs/clinical trials and news about CDC25A / MPIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC25A gene (2 alternative transcripts):

NM_001789.2 NM_201567.1

Unigene Cluster for CDC25A:

Cell division cycle 25 homolog A (S. pombe)

Hs.437705 [show with all ESTs]

Unigene Representative Sequence: NM_001789

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302506(uc003csh.1) ENST00000351231(uc003csi.1 uc021wxk.1)

ENST00000459900 ENST00000443342 ENST00000437972

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CDC25A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC25A
		8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC25A (see all 70):
		hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: CDC25A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC25A (see all 7) OriGene shRNA RFP: CDC25A OriGene siRNA: CDC25A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC25A
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDC25A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC25A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC25A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC25A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC25A

Additional cDNA sequence:

AF277722.1 AK290554.1 AY137580.1 BC007401.2 BC018642.2 EU812118.1 FJ866789.1 M81933.1

6 DOTS entries:

DT.209227 DT.306884 DT.92428522 DT.75100887 DT.120889888 DT.92064783

24/112 AceView cDNA sequences (see all 112):

BE298834 BF221494 BQ883064 NM_201567 BM715615 BX114416 AW235354 AA648922

NM_001789 AW139217 BU631902 BU149531 BC018642 BQ689872 BM971031 AI800535

BF968769 AY137580 BE409135 BC007401 AI671182 BQ065803 AI917350 BF221662

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15a	·	15b	^	16
SP1:
SP2:																									-
SP3:																									-
SP4:
SP5:

ECgene alternative splicing isoforms for CDC25A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC25A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CDC25A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Intrahepatic Biliary Tree

Biliary Epithelial Cells

Liver

Intrahepatic Biliary Tree

Immature Biliary Epithelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDC25A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC25A

SOURCE GeneReport for Unigene cluster: Hs.437705

SABiosciences Expression via Pathway-Focused PCR Arrays including CDC25A:

Cancer Drug Targets in human mouse rat

Cell Cycle in human mouse rat

DNA Damage Signaling Pathway in human mouse rat

p53 Signaling Pathway in human mouse rat

Protein Phosphatases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC25A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDC25A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC25A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC25A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CDC25A gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDC25A¹	cell division cycle 25 homolog A (S. pombe)	67.65(n) 65.16(a)		420375 NM_001199572.1 NP_001186501.1
lizard (Anolis carolinensis)	Reptilia	CDC25A⁶	--	78(a)	1 ↔ 1	AAWZ02038835(260-9896)
African clawed frog (Xenopus laevis)	Amphibia	LOC398141²	tyrosine phosphatase Cdc25A	73.19(n)		AF090829.1
zebrafish (Danio rerio)	Actinopterygii	cdc25²	cdc25	77.94(n)		57925 AF212941.1
fruit fly (Drosophila melanogaster)	Insecta	stg³	protein amino acid dephosphorylation protein tyrosine phosphatase less	47(a) (best of 2)		3 99A5 --
worm (Caenorhabditis elegans)	Secernentea	cdc-25.3⁶ cdc-25.4⁶ (see all 4)	M-phase inducer phosphatase cdc-25.3 Cell Division Cycle related family member (cdc-25.... (see all 4)	24(a) 24(a) (see all 4)	possible ortholog possible ortholog (see all 4)	III(8916339-8917853) II(10188251-10189346)

ENSEMBL Gene Tree for CDC25A (if available)
TreeFam Gene Tree for CDC25A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDC25A gene

CDC25B² CDC25C²

3 SIMAP similar genes for CDC25A using alignment to 4 protein entries: MPIP1_HUMAN (see all proteins):

DKFZp686G14213 CDC25B CDC25C

CDC25A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11130158^1,2	C,F,A,H	--	48198300(+)	`CATACC/ATAAAG`	2	--	ds500¹		13		NA EA WA CSA	869
rs17079998^1,2	C,F,H	--	48198311(+)	`GACCAT/CGTGTT`	2	--	ds500¹		9		NA NS CSA	934
rs143697086^1,2		--	48198327(+)	`TTCTGA/GGCGTC`	2	--	ds500¹		0	--	--	--	--
rs6763139^1,2	C,F,A	--	48198455(+)	`aatgcG/Agggat`	2	--	ds500¹		1		WA	118
rs189204817^1,2		--	48198470(+)	`AGCATA/GAGCCA`	2	--	ds500¹		0	--	--	--	--
rs148099009^1,2		--	48198524(+)	`TTGCAA/GATCAA`	2	--	ds500¹		0	--	--	--	--
rs140929323^1,2		--	48198906(+)	`AAACCC/TGTAAC`	2	--	ut3¹		0	--	--	--	--
rs150274172^1,2		--	48198932(+)	`CTCCAA/GTATCA`	2	--	ut3¹		0	--	--	--	--
rs181081390^1,2		--	48199168(+)	`ACAACC/TGGTGA`	2	--	ut3¹		0	--	--	--	--
rs116119378^1,2	C,F	--	48199175(+)	`GTGATG/AATTCA`	2	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for CDC25A (48198636 - 48229892 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDC25A
1 CNV: 4334

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC25A

DNA2.0 Custom Variant and Variant Library Synthesis for CDC25A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC25A for disorders           About GeneDecksing

OMIM gene information: 116947    OMIM disorders: --

20/53 diseases for CDC25A (see all 53):    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma anaplastic large cell lymphoma ataxia telangiectasia

hodgkin's lymphoma cutaneous malignant melanoma oral squamous cell carcinoma squamous cell carcinoma

polycystic kidney disease myeloid leukemia acute myeloid leukemia kidney disease

carcinoma ovarian cancer eye disease cervical carcinoma

hepatocellular carcinoma ovarian carcinoma pandas laryngitis

1 disease from the University of Copenhagen DISEASES database for CDC25A:

Cancer

10/28 Novoseek disease relationships for CDC25A gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	55.6	4	15028555 (2), 16440198 (1), 17111124 (1)
ataxia telangiectasia	55.2	6	19062161 (1), 17431115 (1), 17015478 (1), 17172433 (1)
cancer	47.5	42	18167338 (2), 18794133 (2), 19738433 (1), 10754492 (1) (see all 30)
indolent lymphoma	40	2	10754492 (2)
tumors	37.6	47	9751615 (3), 10995786 (2), 17111124 (2), 16818510 (2) (see all 25)
neoplastic transformation	29.2	1	17361412 (1)
breast cancer	29.1	25	18665474 (4), 14603247 (3), 16598773 (3), 10995786 (2) (see all 12)
carcinoma squamous cell	23.2	5	11487274 (2), 17111124 (1), 18792900 (1), 9192810 (1)
mammary tumor	21.8	2	19075565 (1)
prostate cancer	19.6	8	19013180 (4), 14673957 (1), 14652289 (1)

Human Genome Epidemiology (HuGE) Navigator: CDC25A (11 documents)

Export disorders for CDC25A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC25A gene, integrated from 9 sources (see all 326):
(articles sorted by number of sources associating them with CDC25A)

Utopia: connect your pdf to the dynamic
world of online information

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)^{1, 2, 3, 9} Galaktionov K.I. and Beach D. (1991)
Ubiquitin hydrolase Dub3 promotes oncogenic transform ation by stabilizing Cdc25A. (PubMed id 20228808)^{1, 2, 9} Pereg Y....Dixit V.M. (2010)
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PubMed id 12676925)^{1, 2, 9} Xiao Z.... Zhang H. (2003)
NEK11: linking CHK1 and CDC25A in DNA damage checkpoi nt signaling. (PubMed id 20090422)^{1, 2, 9} SA...Helin K. (2010)
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PubMed id 12759351)^{1, 2, 9} Hassepass I.... Hoffmann I. (2003)
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. (PubMed id 11298456)^{1, 2, 9} Falck J....Lukas J. (2001)
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. (PubMed id 12399544)^{1, 2, 9} Zhao H.... Piwnica-Worms H. (2002)
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. (PubMed id 14559997)^{1, 2, 9} Chen M.-S.... Piwnica-Worms H. (2003)
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. (PubMed id 9604936)^{1, 2, 9} Fauman E.B.... Saper M.A. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 993	HGNC: 1725	AceView: CDC25A	Ensembl:ENSG00000164045	euGenes: HUgn993
ECgene: CDC25A	Kegg: 993	H-InvDB: CDC25A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC25A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDC25A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc25a/

Intellectual Property for CDC25A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDC25A gene:
Search GeneIP for patents involving CDC25A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC25A
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore small molecules (inhibitor) for CDC25A

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CDC25A (CDC25A)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CDC25A		OriGene shRNA RFP for CDC25A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC25A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC25A
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CDC25A		OriGene 3'-UTR Clone for CDC25A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDC25A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CDC25A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CDC25A		OriGene Custom Protein Services for CDC25A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC25A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC25A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC25A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC25A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC25A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC25A

	GenScript Custom Purified and Recombinant Proteins Services for CDC25A		GenScript cDNA clones with any tag delivered in your preferred vector for CDC25A
	GenScript Custom Assay Services for CDC25A		GenScript Superior Antibodies for CDC25A
	GenScript Custom overexpressing Cell Line Services for CDC25A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CDC25A

	Regulatory tfbs in CDC25A promoter
	Search Chromatin IP Primers for CDC25A
	RT² qPCR Primer Assay in human, mouse, rat CDC25A
	GNC Network for CDC25A
	SABiosciences PCR Arrays including human, mouse, rat CDC25A

Tocris compounds for CDC25A

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for CDC25A
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs/Proteins for CDC25A
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CDC25A antibodies
	CDC25A proteins
	CDC25A lysates

	Antibodies for CDC25A
	See all of Abcam's Antibodies, Kits and Proteins for CDC25A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CDC25A

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for CDC25A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A

	SwitchGear 3'UTR luciferase reporter plasmids for CDC25A
	SwitchGear Promoter luciferase reporter plasmids for CDC25A

ThermoFisher Antibody for CDC25A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDC25A

Sirion Biotech Customized:

	stable knockdown cell line services for CDC25A
	inducible knockdown cell line services for CDC25A
	design and validation of potent shRNA sequences against CDC25A
	adenovirus for potent knockdown of CDC25A
	adenovirus for overexpression of CDC25A
	stable overexpressing cell line services for CDC25A
	inducible overexpressing cell line services for CDC25A

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDC25A gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CDC25A Gene

cell division cycle 25A

Aliases
for CDC25A gene

Summaries
for CDC25A gene

Genomic Views
for CDC25A gene

Proteins
for CDC25A gene

Protein Domains /
Families
for CDC25A gene

Function
for CDC25A gene

Pathways & Interactions
for CDC25A gene

Drugs & Compounds
for CDC25A gene

Transcripts
for CDC25A gene

Expression
for CDC25A gene

Orthologs
for CDC25A gene

Paralogs
for CDC25A gene

Genomic Variants
for CDC25A gene

Disorders / Diseases
for CDC25A gene

Publications
for CDC25A gene

External Searches for CDC25A gene

Genome Databases showing CDC25A gene

Other Databases showing CDC25A gene

Specialized Databases showing CDC25A gene

Intellectual Property
for CDC25A gene

Products
for CDC25A gene

View Random Gene

Lymphoma
indolent lymphoma
mammary tumor
BREAST CARCINOMA
GASTRIC CARCINOMA
Melanoma
Colon Cancer
Ovarian Cancer
Retinoblastoma
OVARIAN CARCINOMA
Carcinoma
Carcinoma Squamous Cell
Myeloid Leukemia Chronic
Leukemia
Breast Cancer
prostate cancer
NSCLC
Tumors
primary tumor
Metastasis
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Lymphoma Non-Hodgkins
Neck Cancer
Cancer
Cancer Lung
neoplastic transformation
Ataxia Telangiectasia

Advanced Search

Export list of displayed genes

CDC25A Gene

cell division cycle 25A

Aliasesfor CDC25A gene

Summariesfor CDC25A gene

Genomic Viewsfor CDC25A gene

Proteinsfor CDC25A gene

Protein Domains /Familiesfor CDC25A gene

Functionfor CDC25A gene

Pathways & Interactionsfor CDC25A gene

Drugs & Compoundsfor CDC25A gene

Transcriptsfor CDC25A gene

Expression for CDC25A gene

Orthologsfor CDC25A gene

Paralogsfor CDC25A gene

Genomic Variantsfor CDC25A gene

Disorders / Diseasesfor CDC25A gene

Publicationsfor CDC25A gene

External Searches for CDC25A gene

Genome Databases showing CDC25A gene

Other Databases showing CDC25A gene

Specialized Databases showing CDC25A gene

Intellectual Propertyfor CDC25A gene

Productsfor CDC25A gene

View Random Gene

Aliases
for CDC25A gene

Summaries
for CDC25A gene

Genomic Views
for CDC25A gene

Proteins
for CDC25A gene

Protein Domains /
Families
for CDC25A gene

Function
for CDC25A gene

Pathways & Interactions
for CDC25A gene

Drugs & Compounds
for CDC25A gene

Transcripts
for CDC25A gene

Expression
for CDC25A gene

Orthologs
for CDC25A gene

Paralogs
for CDC25A gene

Genomic Variants
for CDC25A gene

Disorders / Diseases
for CDC25A gene

Publications
for CDC25A gene

Intellectual Property
for CDC25A gene

Products
for CDC25A gene