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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC25A Gene

protein-coding   GIFtS: 72
GCID: GC03M048173

Cell Division Cycle 25A

(Previous names: cell division cycle 25A, cell division cycle 25 homolog...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 25A1 2     Cell Division Cycle 25 Homolog A (S. Pombe)1
Dual Specificity Phosphatase Cdc25A2 3     CDC25A22
EC 3.1.3.483 8     CDC25A2-CAG Isoform2
Cell Division Cycle 25 Homolog A (S. Cerevisiae)1     M-Phase Inducer Phosphatase 12

External Ids:    HGNC: 17251   Entrez Gene: 9932   Ensembl: ENSG000001640457   OMIM: 1169475   UniProtKB: P303043   

Export aliases for CDC25A gene to outside databases

Previous GC identifers: GC03P048003 GC03M047482 GC03M048019 GC03M048160 GC03M048159


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC25A Gene:
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase
of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is
specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from
progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been
demonstrated. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDC25A Gene: 
CDC25A (cell division cycle 25A) is a protein-coding gene. Diseases associated with CDC25A include non-hodgkin lymphoma, and cutaneous malignant melanoma, and among its related super-pathways are Cell cycle Role of SCF complex in cell cycle regulation and Mitotic G1-G1/S phases. GO annotations related to this gene include protein tyrosine phosphatase activity and protein kinase binding. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with
cyclin E, in vitro

summary for CDC25A Gene:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC25A gene promoter:
         CREB   Sp1   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC25A promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC25A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC25A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CDC25A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048173:  view genomic region     (about GC identifiers)

Start:
48,198,636 bp from pter      End:
48,229,892 bp from pter
Size:
31,257 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 1  
Size: 524 amino acids; 59087 Da
Subunit: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with
CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions
with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates
CDC25A phosphorylation and degradation in response to infrared-induced DNA damages
1 PDB 3D structure from and Proteopedia for CDC25A:
1C25 (3D)    
Secondary accessions: Q8IZH5 Q96IL3 Q9H2F2
Alternative splicing: 2 isoforms:  P30304-1   P30304-2   

Explore the universe of human proteins at neXtProt for CDC25A: NX_P30304

Explore proteomics data for CDC25A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell
    cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle
    arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits
    CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent
    proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent
    phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated
    polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity.
    Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation
  • UniProtKB: Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1
    during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and
    FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its
    stabilization
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30304

  • 4/7 DME Specific Peptides for CDC25A (P30304) (see all 7)
     GGHIKGA  FHCEFSS  GKHQDLKY  LKGGYKEFF 

    CDC25A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC25A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001780.2  NP_963861.1  

    ENSEMBL proteins: 
     ENSP00000303706   ENSP00000343166   ENSP00000416483   ENSP00000404285  
    Reactome Protein details: P30304
    Human Recombinant Protein Products for CDC25A: 
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    OriGene MassSpec for CDC25A 
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    Novus Biologicals CDC25A Proteins
    Novus Biologicals CDC25A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CDC25A
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    CDC25A for ontologies           About GeneDecksing



    CDC25A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC25A
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    LSBio Antibodies in human, mouse, rat for CDC25A 

    Assay Products for CDC25A: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTP3: Protein tyrosine phosphatases / Class III Cys-based PTPs

    2 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30304

    ProtoNet protein and cluster: P30304

    2 Blocks protein domains:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304
    Domain: The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative
    phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain


    CDC25A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPIP1_HUMAN, P30304
    Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
    Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with
    cyclin E, in vitro
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation

         Genatlas biochemistry entry for CDC25A:
    cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form
    A,regulator of the cell cycle,putative up-regulated c-Myc target gene,

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI11298456
    GO:0019901protein kinase binding IPI--
         
    CDC25A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDC25A:
     Decreased focal adhesion (FA)   Increased Erk phosphorylation   Increased cell death in breast  Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdc25a):
     cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  mortality/aging  normal  skeleton 
     tumorigenesis 

    CDC25A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDC25A: Cdc25atm1.1Hpw Cdc25atm1Kiyo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDC25A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDC25A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC25A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC25A 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC25A:
    hsa-mir-34a (MIRT001011), hsa-mir-503 (MIRT000648), hsa-let-7b (MIRT002296), hsa-mir-424 (MIRT000655), hsa-mir-15a (MIRT000284), hsa-mir-449a (MIRT003186), hsa-mir-21 (MIRT000157)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC25A
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC25A (see all 70):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC25A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDC25A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC25A

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CDC25A

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDC25A (see all 11)
    OriGene ORF clones in mouse, rat for CDC25A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
    Sino Biological Human cDNA Clone for CDC25A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A
    Sirion Biotech Customized lentivirus for stable overexpression of CDC25A 
                         Customized lentivirus expression plasmids for stable overexpression of CDC25A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC25A About   (see all 30)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation0.39
    Cell cycle ESR1 regulation of G1/S transition0.33
    Cell cycle Regulation of G1/S transition (part 1)0.39
    G0 and Early G10.31
    Cell cycle Cell cycle (generic schema)0.38
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    p53-Independent G1/S DNA damage checkpoint0.91
    Cyclin A:Cdk2-associated events at S phase entry0.88
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    G1/S DNA Damage Checkpoints0.87
    p53-Independent DNA Damage Response0.91
    S Phase0.79
    Cyclin E associated events during G1/S transition 0.89
    Cell Cycle Checkpoints0.58
    5Activation of ATR in response to replication stress
    G2/M Checkpoints0.86
    Activation of ATR in response to replication stress0.86

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for CDC25A (see all 8)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Role of APC in cell cycle regulation
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle ESR1 regulation of G1/S transition

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC25A (see all 7)
        G1-S Phase Transition
    Estrogen-mediated S-Phase Entry
    ATM Pathway
    Cyclins and Cell Cycle Regulation
    STAT3 Pathway

    2 Cell Signaling Technology (CST) Pathways for CDC25A
        Phosphatases
    Cell Cycle / Checkpoint Control

    5/8 GeneGo (Thomson Reuters) Pathways for CDC25A (see all 8)
        Cell cycle Role of APC in cell cycle regulation
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)

    5/10 BioSystems Pathways for CDC25A (see all 10)
        DNA damage response
    Cell cycle
    G1 to S cell cycle control
    miRNAs involved in DDR
    Integrated Breast Cancer Pathway


    5/22        Reactome Pathways for CDC25A (see all 22)
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    E2F-enabled inhibition of pre-replication complex formation
    G0 and Early G1


    3         Kegg Pathways  (Kegg details for CDC25A):
        Cell cycle
    Progesterone-mediated oocyte maturation
    MicroRNAs in cancer


    CDC25A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC25A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/141 Interacting proteins for CDC25A (P303041, 2, 3 ENSP000003037064) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-49914 MINT-49900 MINT-49902 I2D: score=5 STRING: ENSP00000359206
    YWHAEP622582, 3, ENSP000002643354MINT-19304 MINT-19397 MINT-19303 I2D: score=5 STRING: ENSP00000264335
    CHEK2O960172, 3, ENSP000003720234MINT-17354 MINT-15591 I2D: score=4 STRING: ENSP00000372023
    CDK2P249412, 3, ENSP000002669704MINT-8219811 I2D: score=4 STRING: ENSP00000266970
    DUSP8Q132022, 3, ENSP000003295394MINT-8250767 I2D: score=2 STRING: ENSP00000329539
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS11139144
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000087M phase of mitotic cell cycle ----
    GO:0000278mitotic cell cycle TAS--

    CDC25A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC25A for compounds           About GeneDecksing

    EMD Millipore small molecules for CDC25A:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDC25A

    Compounds for CDC25A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]

    2 HMDB Compounds for CDC25A    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/29 Novoseek inferred chemical compound relationships for CDC25A gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzamide riboside 70 2 11966440 (1), 10467347 (1)
    se-methylselenocysteine 52.5 2 15213307 (1), 16518418 (1)
    tyrosine 50.4 24 9989807 (3), 12679193 (1), 16809424 (1), 15209522 (1) (see all 22)
    camptothecin 46.7 3 16928871 (2), 12676925 (1)
    threonine 39.6 3 11804965 (1), 19075567 (1), 20368335 (1)
    artesunate 39.2 1 12869643 (1)
    arsenite 34.9 7 17545210 (6)
    roscovitine 33.3 2 11752153 (1), 12801928 (1)
    bpde 33.2 3 16912045 (2), 17602818 (1)
    fudr 27.5 9 15374972 (4), 16931916 (2)

    Search CenterWatch for drugs/clinical trials and news about CDC25A / MPIP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC25A gene (2 alternative transcripts): 
    NM_001789.2  NM_201567.1  

    Unigene Cluster for CDC25A:

    Cell division cycle 25A
    Hs.437705  [show with all ESTs]
    Unigene Representative Sequence: NM_001789
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302506(uc003csh.1) ENST00000351231(uc003csi.1 uc021wxk.1)
    ENST00000459900 ENST00000443342 ENST00000437972
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC25A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A
    Sirion Biotech Customized lentivirus for stable overexpression of CDC25A 
                         Customized lentivirus expression plasmids for stable overexpression of CDC25A 
    Primer
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    OriGene qPCR primer pairs and template standards for CDC25A
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC25A
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    Additional mRNA sequence: 

    AF277722.1 AK290554.1 AY137580.1 BC007401.2 BC018642.2 EU812118.1 FJ866789.1 M81933.1 

    6 DOTS entries:

    DT.209227  DT.306884  DT.92428522  DT.75100887  DT.120889888  DT.92064783 

    24/112 AceView cDNA sequences (see all 112):

    AI671182 BQ883064 BF221494 BF968769 AI917350 BQ065803 AY137580 AA648922 
    BU631902 AW235354 AI800535 BC007401 BX114416 BM971031 BM715615 BC018642 
    BE409135 BU149531 AW139217 NM_201567 NM_001789 BQ689872 BE298834 CD612835 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                                          
    SP2:                                                                          -                                                               
    SP3:                                                                          -                                                               
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CDC25A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC25A expression in normal human tissues (normalized intensities)      CDC25A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDC25A Expression
    About this image


    CDC25A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
             cord blood   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     Smooth Muscle (Muscoskeletal System)
             Human Intestinal Smooth Muscle Cells (HISMC)   
     
     Peripheral Nervous System (Nervous System)
             Human Perineurial Cells (HPC)   
     
     Intestine (Muscoskeletal System)
             Human Intestinal Smooth Muscle Cells (HISMC)   

    See CDC25A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC25A

    SOURCE GeneReport for Unigene cluster: Hs.437705
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDC25A: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC25A gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc25a1 , 5 cell division cycle 25 homolog A (S. pombe)5
    cell division cycle 25A1
    85.83(n)1
    85.96(a)1
      9 (59.81 cM)5
    125301  NM_007658.31  NP_031684.31 
     1098755795 
    chicken
    (Gallus gallus)
    Aves CDC25A1 cell division cycle 25 homolog A (S. pombe) 67.65(n)
    65.16(a)
      420375  NM_001199572.1  NP_001186501.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC25A6
    CDC25A6
    Uncharacterized protein
    71(a)
    40(a)
    1 ↔ 1
    possible ortholog
    AAWZ02038835(63-10242)
    GL343332.1(1327009-1338030)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981412 tyrosine phosphatase Cdc25A 73.19(n)    AF090829.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc252 cdc25 77.94(n)   57925  AF212941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stg3 protein amino acid dephosphorylation
    protein tyrosine phosphatase less
    47(a)
    (best of 2)
      3 99A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-25.46
    cdc-25.36
    (see all 4)
    M-phase inducer phosphatase cdc-25.3
    (see all 4)
    23(a)
    22(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(10188310-10189405)
    III(8916417-8917931)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIH16
    Protein tyrosine phosphatase involved in cell cycl...
    16(a)
    1 → many
    XIII(341856-343520)


    ENSEMBL Gene Tree for CDC25A (if available)
    TreeFam Gene Tree for CDC25A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC25A gene
    CDC25B2  CDC25C2  
    3 SIMAP similar genes for CDC25A using alignment to 4 protein entries:     MPIP1_HUMAN (see all proteins):
    DKFZp686G14213    CDC25B    CDC25C

    CDC25A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 SNPs in CDC25A are shown (see all 646)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111301581,2
    C,F,A,H--48198300(+) CATACC/ATAAAG 2 -- ds500113Minor allele frequency- A:0.32NA EA WA CSA 869
    rs170799981,2
    C,F,H--48198311(+) GACCAT/CGTGTT 2 -- ds50019Minor allele frequency- C:0.06NA NS CSA 934
    rs1436970861,2
    --48198327(+) TTCTGA/GGCGTC 2 -- ds50010--------
    rs67631391,2
    C,F,A--48198455(+) aatgcG/Agggat 2 -- ds50011Minor allele frequency- A:0.30WA 118
    rs1892048171,2
    --48198470(+) AGCATA/GAGCCA 2 -- ds50010--------
    rs1480990091,2
    --48198524(+) TTGCAA/GATCAA 2 -- ds50010--------
    rs1409293231,2
    C--48198906(+) AAACCC/TGTAAC 2 -- ut310--------
    rs1502741721,2
    --48198932(+) CTCCAA/GTATCA 2 -- ut310--------
    rs1810813901,2
    --48199168(+) ACAACC/TGGTGA 2 -- ut310--------
    rs1161193781,2
    C,F--48199175(+) GTGATG/AATTCA 2 -- ut311Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for CDC25A (48198636 - 48229892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDC25A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834682CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116947    OMIM disorders: --

    20/41 diseases for CDC25A (see all 41):    About MalaCards
    non-hodgkin lymphoma    cutaneous malignant melanoma    pandas    hodgkin's lymphoma
    ataxia telangiectasia    anaplastic large cell lymphoma    eye disease    polycystic kidney disease
    esophageal adenocarcinoma    kidney disease    retinoblastoma    azoospermia
    esophageal cancer    hepatocellular carcinoma    oral squamous cell carcinoma    laryngitis
    ataxia    colon cancer    myeloid leukemia    cervicitis

    1 disease from the University of Copenhagen DISEASES database for CDC25A:
    Cancer

    CDC25A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/28 Novoseek inferred disease relationships for CDC25A gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 55.6 4 15028555 (2), 16440198 (1), 17111124 (1)
    ataxia telangiectasia 55.2 6 19062161 (1), 17431115 (1), 17015478 (1), 17172433 (1)
    cancer 47.5 42 18167338 (2), 18794133 (2), 19738433 (1), 10754492 (1) (see all 30)
    indolent lymphoma 40 2 10754492 (2)
    tumors 37.6 47 9751615 (3), 10995786 (2), 17111124 (2), 16818510 (2) (see all 25)
    neoplastic transformation 29.2 1 17361412 (1)
    breast cancer 29.1 25 18665474 (4), 14603247 (3), 16598773 (3), 10995786 (2) (see all 12)
    carcinoma squamous cell 23.2 5 11487274 (2), 17111124 (1), 18792900 (1), 9192810 (1)
    mammary tumor 21.8 2 19075565 (1)
    prostate cancer 19.6 8 19013180 (4), 14673957 (1), 14652289 (1)

    Genetic Association Database (GAD): CDC25A
    Human Genome Epidemiology (HuGE) Navigator: CDC25A (11 documents)

    Export disorders for CDC25A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC25A gene, integrated from 9 sources (see all 330):
    (articles sorted by number of sources associating them with CDC25A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)1, 2, 3, 9 Galaktionov K.I. and Beach D. (1991)
    2. Ubiquitin hydrolase Dub3 promotes oncogenic transform ation by stabilizing Cdc25A. (PubMed id 20228808)1, 2, 9 Pereg Y....Dixit V.M. (2010)
    3. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PubMed id 12676925)1, 2, 9 Xiao Z.... Zhang H. (2003)
    4. NEK11: linking CHK1 and CDC25A in DNA damage checkpoi nt signaling. (PubMed id 20090422)1, 2, 9 SA...Helin K. (2010)
    5. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PubMed id 12759351)1, 2, 9 Hassepass I.... Hoffmann I. (2003)
    6. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. (PubMed id 11298456)1, 2, 9 Falck J....Lukas J. (2001)
    7. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. (PubMed id 12399544)1, 2, 9 Zhao H.... Piwnica-Worms H. (2002)
    8. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. (PubMed id 14559997)1, 2, 9 Chen M.-S.... Piwnica-Worms H. (2003)
    9. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. (PubMed id 9604936)1, 2, 9 Fauman E.B.... Saper M.A. (1998)
    10. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 993 HGNC: 1725 AceView: CDC25A Ensembl:ENSG00000164045 euGenes: HUgn993
    ECgene: CDC25A Kegg: 993 H-InvDB: CDC25A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC25A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC25A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC25A gene:
    Search GeneIP for patents involving CDC25A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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