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Aliases for CDC25A Gene

Aliases for CDC25A Gene

  • Cell Division Cycle 25A 2 3
  • EC 4 64
  • Cell Division Cycle 25 Homolog A (S. Cerevisiae) 2
  • Cell Division Cycle 25 Homolog A (S. Pombe) 2
  • Dual Specificity Phosphatase CDC25A 3
  • Dual Specificity Phosphatase Cdc25A 4
  • M-Phase Inducer Phosphatase 1 3
  • CDC25 Isoform A1-CAG 3
  • CDC25A2-CAG Isoform 3
  • CDC25A2 3

External Ids for CDC25A Gene

Summaries for CDC25A Gene

Entrez Gene Summary for CDC25A Gene

  • CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC25A Gene

CDC25A (Cell Division Cycle 25A) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25C.

UniProtKB/Swiss-Prot for CDC25A Gene

  • Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro

Tocris Summary for CDC25A Gene

  • Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25 activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation, interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex. Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex. Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit mitosis.

Gene Wiki entry for CDC25A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC25A Gene

Genomics for CDC25A Gene

Genomic Location for CDC25A Gene

48,157,146 bp from pter
48,188,402 bp from pter
31,257 bases
Minus strand

Genomic View for CDC25A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC25A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC25A Gene

Regulatory Elements for CDC25A Gene

Proteins for CDC25A Gene

  • Protein details for CDC25A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    M-phase inducer phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • Q8IZH5
    • Q96IL3
    • Q9H2F2

    Protein attributes for CDC25A Gene

    524 amino acids
    Molecular mass:
    59087 Da
    Quaternary structure:
    • Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages.

    Three dimensional structures from OCA and Proteopedia for CDC25A Gene

    Alternative splice isoforms for CDC25A Gene


neXtProt entry for CDC25A Gene

Proteomics data for CDC25A Gene at MOPED

Selected DME Specific Peptides for CDC25A Gene

Post-translational modifications for CDC25A Gene

  • Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys169, Lys343, and Lys372

Other Protein References for CDC25A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CDC25A Gene

Gene Families for CDC25A Gene

  • PTP3 :Protein tyrosine phosphatases / Class III Cys-based PTPs

Protein Domains for CDC25A Gene


  • The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction.:
    • P30304
  • Contains 1 rhodanese domain.:
    • P30304
  • Belongs to the MPI phosphatase family.:
    • P30304
genes like me logo Genes that share domains with CDC25A: view

Function for CDC25A Gene

Molecular function for CDC25A Gene

GENATLAS Biochemistry: cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form A,regulator of the cell cycle,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation
UniProtKB/Swiss-Prot Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro

Enzyme Numbers (IUBMB) for CDC25A Gene

Gene Ontology (GO) - Molecular Function for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 11298456
GO:0019901 protein kinase binding IPI 21376736
genes like me logo Genes that share ontologies with CDC25A: view
genes like me logo Genes that share phenotypes with CDC25A: view

Animal Models for CDC25A Gene

MGI Knock Outs for CDC25A:

No data available for Transcription Factor Targeting and HOMER Transcription for CDC25A Gene

Localization for CDC25A Gene

Subcellular locations from

Jensen Localization Image for CDC25A Gene COMPARTMENTS Subcellular localization image for CDC25A gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC25A: view

Pathways for CDC25A Gene

genes like me logo Genes that share pathways with CDC25A: view

Gene Ontology (GO) - Biological Process for CDC25A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 11139144
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000087 mitotic M phase --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with CDC25A: view

Compounds for CDC25A Gene

(1) Tocris Compounds for CDC25A Gene

Compound Action Cas Number
NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor [93718-83-3]

(2) HMDB Compounds for CDC25A Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
  • Dihydrogen oxide

(29) Novoseek inferred chemical compound relationships for CDC25A Gene

Compound -log(P) Hits PubMed IDs
benzamide riboside 70 2
se-methylselenocysteine 52.5 2
tyrosine 50.4 24
camptothecin 46.7 3
threonine 39.6 3
genes like me logo Genes that share compounds with CDC25A: view

Transcripts for CDC25A Gene

Unigene Clusters for CDC25A Gene

Cell division cycle 25A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP2: -
SP3: -

Relevant External Links for CDC25A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC25A Gene

mRNA expression in normal human tissues for CDC25A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDC25A Gene

This gene is overexpressed in Testis (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDC25A Gene

SOURCE GeneReport for Unigene cluster for CDC25A Gene Hs.437705

genes like me logo Genes that share expressions with CDC25A: view

Orthologs for CDC25A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC25A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC25A 36
  • 99.55 (n)
  • 99.62 (a)
CDC25A 37
  • 100 (a)
(Bos Taurus)
Mammalia CDC25A 36
  • 90.23 (n)
  • 91 (a)
CDC25A 37
  • 90 (a)
(Canis familiaris)
Mammalia CDC25A 36
  • 90.18 (n)
  • 91.97 (a)
CDC25A 37
  • 92 (a)
(Mus musculus)
Mammalia Cdc25a 36
  • 85.83 (n)
  • 85.96 (a)
Cdc25a 16
Cdc25a 37
  • 82 (a)
(Monodelphis domestica)
Mammalia CDC25A 37
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia CDC25A 37
  • 71 (a)
(Rattus norvegicus)
Mammalia Cdc25a 36
  • 86.09 (n)
  • 86.35 (a)
(Gallus gallus)
Aves CDC25A 36
  • 67.65 (n)
  • 65.16 (a)
CDC25A 37
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
-- 37
  • 40 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398141 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc25a 36
  • 60.26 (n)
  • 55.83 (a)
Str.6078 36
(Danio rerio)
Actinopterygii cdc25 36
  • 56.84 (n)
  • 52.03 (a)
cdc25 37
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta stg 37
  • 28 (a)
twe 37
  • 26 (a)
stg 38
  • 47 (a)
twe 38
  • 34 (a)
(Caenorhabditis elegans)
Secernentea cdc-25.1 37
  • 18 (a)
cdc-25.2 37
  • 20 (a)
cdc-25.3 37
  • 24 (a)
cdc-25.4 37
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIH1 37
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1787 37
  • 37 (a)
Species with no ortholog for CDC25A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC25A Gene

Gene Tree for CDC25A (if available)
Gene Tree for CDC25A (if available)

Paralogs for CDC25A Gene

Paralogs for CDC25A Gene

Selected SIMAP similar genes for CDC25A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDC25A: view

Variants for CDC25A Gene

Sequence variations from dbSNP and Humsavar for CDC25A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs17464 -- 48,158,679(-) GCTGC(C/T)CTGAG utr-variant-3-prime
rs936426 -- 48,173,763(+) aaaac(A/G)taaaa intron-variant
rs1042487 -- 48,158,885(-) TCTTT(C/G)CTGCA utr-variant-3-prime
rs1380052 -- 48,185,756(+) CATTA(C/T)TAATA intron-variant
rs1380053 -- 48,185,972(+) TTTGC(A/C)CCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC25A Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV Gain 17160897

Relevant External Links for CDC25A Gene

HapMap Linkage Disequilibrium report

Disorders for CDC25A Gene

(1) University of Copenhagen DISEASES for CDC25A Gene

(28) Novoseek inferred disease relationships for CDC25A Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 55.6 4
ataxia telangiectasia 55.2 4
cancer 47.5 32
indolent lymphoma 40 2
tumors 37.6 30

Relevant External Links for CDC25A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CDC25A: view

No data available for UniProtKB/Swiss-Prot for CDC25A Gene

Publications for CDC25A Gene

  1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PMID: 1836978) Galaktionov K.I. … Beach D. (Cell 1991) 2 3 4 23
  2. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. (PMID: 11298456) Falck J. … Lukas J. (Nature 2001) 3 4 23
  3. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. (PMID: 12399544) Zhao H. … Piwnica-Worms H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  4. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PMID: 12676925) Xiao Z. … Zhang H. (J. Biol. Chem. 2003) 3 4 23
  5. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PMID: 12759351) Hassepass I. … Hoffmann I. (J. Biol. Chem. 2003) 3 4 23

Products for CDC25A Gene

Sources for CDC25A Gene

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