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CDC25A Gene

protein-coding GIFtS: 69

GC03M048173

cell division cycle 25 homolog A (S. pombe)
(Previous names: cell division cycle 25A, cell division cycle 25 homolog A (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDC25A2 ^²
EC 3.1.3.48 ^³

Descriptions
Dual specificity phosphatase Cdc25A ^², ³
M-phase inducer phosphatase 1 ^²
cell division cycle 25 homolog A (S. cerevisiae) ^¹
cell division cycle 25 homolog A (S. pombe) ^²
cell division cycle 25A ^¹, ²

External Ids
HGNC: 1725¹
Entrez Gene: 993²
UniProtKB: P30304³
Ensembl: ENSG00000164045⁷

Search outside databases for aliases for CDC25A gene

Previous GC identifers: GC03P048003 GC03M047482 GC03M048019 GC03M048160 GC03M048159

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDC25A:

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1

to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two

phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells

with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene,

although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding

different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic

progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also

dephosphorylates CDK2 in complex with cyclin E, in vitro

Gene Wiki entry for CDC25A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDC25A gene

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

CDC25A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M048173: (about GC identifiers)

Start:	48,173,672 bp from pter
End:	48,204,805 bp from pter
Size:	31,134 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304 (See protein sequence)

Recommended Name: M-phase inducer phosphatase 1

Size: 524 amino acids; 59087 Da

Subunit: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated.

Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1

and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage

PDB structures from and Proteopedia :

1C25 (3D)

Secondary accessions: Q8IZH5 Q96IL3 Q9H2F2

Alternative splicing: 2 isoforms: P30304-1 P30304-2

Post-translational modifications:

Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint

mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during

checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding

sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178,

Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A¹

Ubiquitinated. Association with the F-box proteins BTRC and FBXW11 targets the protein for

ubiquitination by CUL1 and proteolysis by the ubiquitin-dependent proteasome pathway¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001780.2 NP_963861.1

ENSEMBL proteins:

ENSP00000303706 ENSP00000343166

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CDC25A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDC25A
	Recombinant Proteins from Abcam (Cdc25A)
	Human Recombinant Proteins from Abnova (CDC25A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	18029348
GO:0005654	nucleoplasm	EXP	1828290 10454565 12399544
GO:0005794	Golgi apparatus	IDA	18029348

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Antibodies for CDC25A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CDC25A
	Sigma-Aldrich Antibody Arrays and Antibodies for CDC25A
	R&D Systems Antibodies for CDC25A
	Cell Signaling Technology (CST) Antibodies for CDC25A
	Antibodies from Abcam (Cdc25A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDC25A)
	Novus Biologicals Antibodies for CDC25A

Assays for CDC25A:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CDC25A
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30304

ProtoNet protein and cluster: P30304

2 Blocks protein families:

IPB000751 M-phase inducer phosphatase signature

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304

Domain: The phosphodegron motif mediates interaction with specific F-box proteins when

phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for

this interaction

Similarity: Belongs to the MPI phosphatase family

Similarity: Contains 1 rhodanese domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC25A)
		Millipore RNAi Products for the Analysis of CDC25A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDC25A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001789

Applied Biosystems Silencer® siRNAs for CDC25A

Sigma-Aldrich siRNA and siRNA Panels for CDC25A

Sigma-Aldrich shRNA Panels and shRNA for CDC25A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDC25A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001789
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001789
untagged cDNA clones in CMV expression vector (see all 2): NM_001789

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001789

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic

progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also

dephosphorylates CDK2 in complex with cyclin E, in vitro

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Enzyme regulation: Stimulated by B-type cyclins

Enzyme Number (IUBMB): EC 3.1.3.48

Genatlas biochemistry entry for CDC25A:

cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF)

component),form A,regulator of the cell cycle,putative up-regulated c-Myc target gene,

13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdc25a):

cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
normal	skeleton	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IEA	--
GO:0005515	protein binding	IPI	17292828
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for CDC25A (Your Favorite Gene powered by Ingenuity)

ATM Signaling
Role of CHK Proteins in Cell Cycle Checkpoint Control
Mitotic Roles of Polo-Like Kinase
Cell Cycle: G1/S Checkpoint Regulation
Molecular Mechanisms of Cancer

GeneDecks CDC25A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDC25A

5/125 Interacting proteins for CDC25A (ENSP00000303706³ P30304^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 125 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHEK1	O14757¹	STRING (score=.999) EBI-747671, EBI-974488
MAPKAPK2	P49137¹	STRING (score=.728) EBI-747671, EBI-993299
BTRC	Q9Y297²	STRING (score=.906) MINT-49914 MINT-49900 MINT-49902
YWHAE	P62258²	STRING (score=.904) MINT-19304 MINT-19397 MINT-19303
CHEK2	O96017²	STRING (score=.999) MINT-17354 MINT-15591

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	11139144
GO:0006260	DNA replication	EXP	12791985
GO:0006470	protein amino acid dephosphorylation	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDC25A

Sigma-Aldrich Small Molecules for CDC25A:

Inhibitor

Compounds for CDC25A available from Tocris Bioscience

Compound	Action	CAS number
NSC 95397	Selective Cdc25 dual specificity phosphatase inhibitor	[93718-83-3]
NSC 663284	Potent, selective Cdc25 phosphatase inhibitor	[383907-43-5]

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9 Novoseek chemical compound relationships for CDC25A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	49.46	23	9989807 (3), 12679193 (1), 16809424 (1), 15209522 (1) (see all 21)
threonine	39.09	2	11804965 (1), 19075567 (1)
bpde	34.80	3	16912045 (2), 17602818 (1)
phosphotyrosine	28.26	1	11002421 (1)
selenium	12.24	2	16099479 (1), 17168675 (1)
phosphatidylinositol	4.94	1	16854822 (1)
atp	0.00	1	14551212 (1)
oxygen	0.00	3	15209522 (1), 17018577 (1), 18794133 (1)
thymidine	0.00	1	16407216 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC25A)
		Millipore RNAi Products for the Analysis of CDC25A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDC25A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001789

Sigma-Aldrich siRNA and siRNA Panels for CDC25A

Sigma-Aldrich shRNA Panels and shRNA for CDC25A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001789 NM_201567

REFSEQ mRNAs for CDC25A gene (2 alternative transcripts):

NM_001789.2 NM_201567.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001789 NM_201567

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001789
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001789
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001789

Additional cDNA sequence:

AF277722.1 AK290554.1 AY137580.1 BC007401.2 BC018642.2 M81933.1

6 DOTS entries:

DT.209227 DT.306884 DT.92428522 DT.75100887 DT.120889888 DT.92064783

24/112 AceView cDNA sequences (see all 112 ):

AI800535 AA648922 AY137580 BQ065803 BC018642 BU631902 NM_001789 BU149531

AI671182 BF968769 AW139217 BX114416 BM971031 AI917350 BQ883064 BC007401

BM715615 BQ689872 BE298834 AW235354 BF221494 BE409135 NM_201567 BG818562

highest scoring ESTs for CDC25A:

M81933 AF277722 AI343459 AY137580 BC007401 BC018642 BE267837 BE513704 BE561237 BE743496

Unigene Cluster for CDC25A:

Cell division cycle 25 homolog A (S. pombe)

Hs.437705 [show with all ESTs]

Unigene Representative Sequence: NM_001789

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A (see all 8 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15a	·	15b	^	16
SP1:
SP2:																									-
SP3:																									-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CDC25A

2 Ensembl transcripts including schematic representations:

ENST00000302506 ENST00000351231

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDC25A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDC25A

¹ / ² / ³

8 probe-sets matching CDC25A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1738_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.85	M81933	1.00	1.00	1.00	1
35407_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.67	M81933	1.00	1.00	1.00	1
54538_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.50	AI343459	0.80	1.00	0.91	1
204696_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001789	0.60	1.00	0.82	1
204695_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI343459	0.80	1.00	0.91	1
1555772_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204696_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204695_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDC25A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.437705
Expression variation in blood from EXPOLDB for CDC25A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC25A gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDC25A¹	--	cell division cycle 25 homolog A (S. pombe)	90.18(n) 91.97(a)	484780 XM_541896.2 XP_541896.2
chimpanzee (Pan troglodytes)	CDC25A¹	--	cell division cycle 25 homolog A (S. pombe)	99.55(n) 99.62(a)	460341 XM_516433.2 XP_516433.2
cow (Bos taurus)	CDC25A¹	--	cell division cycle 25 homolog A (S. pombe)	90.23(n) 91(a)	520188 XM_868867.2 XP_873960.1
rat (Rattus norvegicus)	Cdc25a¹	--	cell division cycle 25 homolog A (S. pombe)	86.09(n) 86.35(a)	171102 NM_133571.1 NP_598255.1
mouse (Mus musculus)	Cdc25a^{1, 5}	9 (62.00 cM)⁵	cell division cycle 25 homolog A (S. pombe)^{1, 5}	85.83(n)¹ 85.96(a)¹	12530¹ NM_007658.3¹ NP_031684.3¹ AK077609⁵ AK077991⁵ (see all 18)

About this table Species with no ortholog for CDC25A

ENSEMBL Gene Tree for CDC25A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDC25A gene

CDC25B² CDC25C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/222 NCBI SNPs in CDC25A are shown (see all 222 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3731560^1,2	A,C,F,H	48175232(-)	`TAGACG/ATCCTC`	2	--	ut3¹ ese³		8		NS EU EA WA NA	728
	rs17464^1,2	C,F,H	48175173(-)	`GCTGCT/CCTGAG`	2	--	ut3¹ ese³		14		NA EA NS MN EU WA CSAM	1426
	rs3731485^1,2	C,F,H	48204944(-)	`GCCAAC/GTAGGA`	2	--	ng3¹ tfbs³		7		NS EU EA WA MN	948
	rs3731484^1,2	C,F,H	48205064(-)	`GCCGAT/AGACCT`	2	--	ng3¹		5		NS EU EA WA	576
	rs11130158^1,2	A,C,F	48173304(+)	`CATACC/ATAAAG`	2	--	ng5¹		7		NA EA	504
--	rs6771386^1,2	A,C	48197220(+)	`CATCCA/C/GAGCTG`	3	R/G R/W	mis¹ int¹		0	--	--	--	--
--	rs3731487^1,2	C,F	48204628(-)	`CTGGAG/AGGTCC`	2	--	ut5¹		1		NS	162
--	rs17079998^1,2	F	48173315(+)	`GACCAT/CGTGTT`	2	--	ng5¹		3		NA	142
--	rs6763242^1,2	C	48206459(+)	`attacC/Tgggcg`	2	--	ng3¹		0	--	--	--	--
	rs1042487^1,2	C	48175379(-)	`TCTTTG/CCTGCA`	2	--	ut3¹ ese³		5		MN CSAM EA	408

About this table

HapMap Linkage Disequilibrium images for CDC25A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116947

10/28 Novoseek disease relationships for CDC25A gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	57.02	4	15028555 (2), 16440198 (1), 17111124 (1)
ataxia telangiectasia	56.84	6	19062161 (1), 17431115 (1), 17015478 (1), 17172433 (1)
cancer	43.12	36	18167338 (2), 18794133 (2), 10754492 (1), 10827953 (1) (see all 25)
indolent lymphoma	41.62	2	10754492 (2)
tumors	37.64	45	9751615 (3), 10995786 (2), 17111124 (2), 16818510 (2) (see all 23)
neoplastic transformation	30.94	1	17361412 (1)
breast cancer	27.21	21	18665474 (4), 14603247 (3), 16598773 (3), 10995786 (2) (see all 9)
mammary tumor	23.68	2	19075565 (1)
carcinoma squamous cell	19.48	5	11487274 (2), 17111124 (1), 18792900 (1), 9192810 (1)
prostate cancer	19.37	8	19013180 (4), 14673957 (1), 14652289 (1)

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Human Genome Epidemiology Navigator: CDC25A (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/260 PubMed articles for CDC25A gene (see all 260 ):

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)^{1, 2, 3, 4} Galaktionov K.I. and Beach D. (1991)
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PubMed id 12676925)^{1, 3, 4} Xiao Z.... Zhang H. (2003)
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PubMed id 12759351)^{1, 3, 4} Hassepass I.... Hoffmann I. (2003)
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. (PubMed id 12399544)^{1, 3, 4} Zhao H.... Piwnica-Worms H. (2002)
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. (PubMed id 14559997)^{1, 3, 4} Chen M.-S.... Piwnica-Worms H. (2003)
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. (PubMed id 9604936)^{1, 3, 4} Fauman E.B.... Saper M.A. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. (PubMed id 12676583)^{3, 4} Soerensen C.S.... Lukas J. (2003)
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. (PubMed id 14681206)^{3, 4} Jin J....Harper J.W. (2003)
Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. (PubMed id 11139144)^{3, 4} Wegener S.... Schaller H.C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 993	HGNC: 1725	AceView: CDC25A	Ensembl:ENSG00000164045	euGenes: HUgn993
ECgene: CDC25A	H-InvDB: CDC25A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDC25A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc25a/

Licensable Technologies for CDC25A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDC25A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDC25A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDC25A		Antibodies for CDC25A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDC25A		Small molecules for CDC25A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDC25A)
	Antibodies (CDC25A)
	Chimera RNAi (CDC25A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDC25A

	Recombinant Proteins (Cdc25A)
	Antibodies (Cdc25A)

Search OriGene for CDC25A

Tocris compounds for CDC25A

	Drugs/Proteins for CDC25A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDC25A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDC25A Gene at Home site.
Version 2.41.1
server4.xennexinc.com

CDC25A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CDC25A

Summaries
for CDC25A

Genomic Location
for CDC25A

Proteins
for CDC25A

Protein Domains/
Families
for CDC25A

Gene Function
for CDC25A

Pathways & Interactions
for CDC25A

Drugs & Compounds
for CDC25A

Transcripts
for CDC25A

Expression
for CDC25A

Orthologs
for CDC25A

Paralogs
for CDC25A

SNPs/Variants
for CDC25A

Disorders & Mutations
for CDC25A

Medical News
for CDC25A

Publications
for CDC25A

Search for CDC25A

Genome Databases showing CDC25A

Other Databases showing CDC25A

Specialized Databases showing CDC25A

Licensable Technologies
for CDC25A

Services
for CDC25A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDC25A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CDC25A

Summariesfor CDC25A

Genomic Locationfor CDC25A

Proteinsfor CDC25A

Protein Domains/Familiesfor CDC25A

Gene Functionfor CDC25A

Pathways & Interactionsfor CDC25A

Drugs & Compoundsfor CDC25A

Transcriptsfor CDC25A

Expression for CDC25A

Orthologsfor CDC25A

Paralogsfor CDC25A

SNPs/Variantsfor CDC25A

Disorders & Mutationsfor CDC25A

Medical Newsfor CDC25A

Publicationsfor CDC25A

Search for CDC25A

Genome Databases showing CDC25A

Other Databases showing CDC25A

Specialized Databases showing CDC25A

Licensable Technologiesfor CDC25A

Servicesfor CDC25A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDC25A

Summaries
for CDC25A

Genomic Location
for CDC25A

Proteins
for CDC25A

Protein Domains/
Families
for CDC25A

Gene Function
for CDC25A

Pathways & Interactions
for CDC25A

Drugs & Compounds
for CDC25A

Transcripts
for CDC25A

Expression
for CDC25A

Orthologs
for CDC25A

Paralogs
for CDC25A

SNPs/Variants
for CDC25A

Disorders & Mutations
for CDC25A

Medical News
for CDC25A

Publications
for CDC25A

Licensable Technologies
for CDC25A

Services
for CDC25A