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CDC25A Gene

protein-coding   GIFtS: 72
GCID: GC03M048173

Cell Division Cycle 25A

(Previous names: cell division cycle 25A, cell division cycle 25 homolog...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 25A1 2     CDC25A22
Dual Specificity Phosphatase Cdc25A2 3     CDC25 Isoform A1-CAG2
EC 3.1.3.483 8     CDC25A2-CAG Isoform2
Cell Division Cycle 25 Homolog A (S. Cerevisiae)1     M-Phase Inducer Phosphatase 12
Cell Division Cycle 25 Homolog A (S. Pombe)1     

External Ids:    HGNC: 17251   Entrez Gene: 9932   Ensembl: ENSG000001640457   OMIM: 1169475   UniProtKB: P303043   

Export aliases for CDC25A gene to outside databases

Previous GC identifers: GC03P048003 GC03M047482 GC03M048019 GC03M048160 GC03M048159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC25A Gene:
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase
of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is
specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from
progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been
demonstrated. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDC25A Gene:
CDC25A (cell division cycle 25A) is a protein-coding gene. Diseases associated with CDC25A include pandas, and cutaneous malignant melanoma. GO annotations related to this gene include protein tyrosine phosphatase activity and protein kinase binding. An important paralog of this gene is CDC25B.

UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with
cyclin E, in vitro

summary for CDC25A Gene:
Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25
activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA
damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,
interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated
and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further
phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is
also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.
Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.
Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit
mitosis.

Gene Wiki entry for CDC25A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC25A gene promoter:
         CREB   Sp1   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC25A promoter sequence
   Search Chromatin IP Primers for CDC25A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC25A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CDC25A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048173:  view genomic region     (about GC identifiers)

Start:
48,198,636 bp from pter      End:
48,229,892 bp from pter
Size:
31,257 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304 (See protein sequence)
Recommended Name: M-phase inducer phosphatase 1  
Size: 524 amino acids; 59087 Da
Subunit: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with
CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions
with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates
CDC25A phosphorylation and degradation in response to infrared-induced DNA damages
1 PDB 3D structure from and Proteopedia for CDC25A:
1C25 (3D)    
Secondary accessions: Q8IZH5 Q96IL3 Q9H2F2
Alternative splicing: 2 isoforms:  P30304-1   P30304-2   

Explore the universe of human proteins at neXtProt for CDC25A: NX_P30304

Explore proteomics data for CDC25A at MOPED

Post-translational modifications: 

  • Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell
    cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle
    arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits
    CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent
    proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent
    phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated
    polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity.
    Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation1
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1
    during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and
    FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its
    stabilization1
  • Ubiquitination2 at Lys169, Lys343, Lys372
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDC25A (P30304) (see all 7)
     GGHIKGA  FHCEFSS  GKHQDLKY  LKGGYKEFF 


    See CDC25A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001780.2  NP_963861.1  

    ENSEMBL proteins: 
     ENSP00000303706   ENSP00000343166   ENSP00000416483   ENSP00000404285  
    Reactome Protein details: P30304

    CDC25A Human Recombinant Protein Products:

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    Novus Biologicals CDC25A Proteins
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDC25A
    Browse Proteins at Cloud-Clone Corp.

    CDC25A Antibody Products:

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    CDC25A Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTP3: Protein tyrosine phosphatases / Class III Cys-based PTPs

    2 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR000751 MPI_Phosphatase

    Graphical View of Domain Structure for InterPro Entry P30304

    ProtoNet protein and cluster: P30304

    2 Blocks protein domains:
    IPB000751 M-phase inducer phosphatase signature
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: MPIP1_HUMAN, P30304
    Domain: The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative
    phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction
    Similarity: Belongs to the MPI phosphatase family
    Similarity: Contains 1 rhodanese domain


    CDC25A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MPIP1_HUMAN, P30304
    Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.
    Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with
    cyclin E, in vitro
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Enzyme regulation: Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation

         Genatlas biochemistry entry for CDC25A:
    cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form
    A,regulator of the cell cycle,putative up-regulated c-Myc target gene,

         Enzyme Number (IUBMB): EC 3.1.3.481 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI11298456
    GO:0019901protein kinase binding IPI--
         
    CDC25A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDC25A:
     Decreased focal adhesion (FA)   Increased Erk phosphorylation   Increased cell death in breast  Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdc25a):
     cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  mortality/aging  normal  skeleton 
     tumorigenesis 

    CDC25A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDC25A: Cdc25atm1.1Hpw Cdc25atm1Kiyo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC25A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC25A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC25A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC25A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC25A:
    hsa-mir-18a-3p (MIRT040942), hsa-mir-92a-3p (MIRT049120), hsa-mir-98-5p (MIRT027421), hsa-mir-16-5p (MIRT031451), hsa-mir-503-5p (MIRT000648), hsa-mir-449b-5p (MIRT016138), hsa-mir-484 (MIRT041718), hsa-mir-192-5p (MIRT026127), hsa-mir-34a-5p (MIRT001011), hsa-mir-877-3p (MIRT036976), hsa-let-7i-5p (MIRT046546), hsa-mir-424-5p (MIRT000655), hsa-let-7b-5p (MIRT002296), hsa-mir-15a-5p (MIRT000284), hsa-mir-103a-3p (MIRT027018), hsa-mir-449a (MIRT003186), hsa-mir-21-5p (MIRT000157), hsa-mir-193b-3p (MIRT016313)

    Block miRNA regulation of human, mouse, rat CDC25A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC25A (see all 70):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCDC25A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDC25A
    Predesigned siRNA for gene silencing in human, mouse, rat CDC25A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CDC25A

    Clone
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    OriGene clones in human, mouse for CDC25A (see all 12)
    OriGene ORF clones in mouse, rat for CDC25A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
    Sino Biological Human cDNA Clone for CDC25A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC25A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDC25A
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC25A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    CDC25A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC25A About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    E2F-enabled inhibition of pre-replication complex formation0.00
    G1 to S cell cycle control0.35
    G1/S-Specific Transcription0.00
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    p53-Independent DNA Damage Response0.91
    Cyclin E associated events during G1/S transition0.86
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    Cyclin A-Cdk2-associated events at S phase entry0.85
    p53-Independent G1/S DNA damage checkpoint0.91
    S Phase0.78
    G1/S DNA Damage Checkpoints0.87
    Cell Cycle Checkpoints0.58
    4Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC25A (see all 7)
        G1-S Phase Transition
    Estrogen-mediated S-Phase Entry
    ATM Pathway
    Cyclins and Cell Cycle Regulation
    STAT3 Pathway

    2 Cell Signaling Technology (CST) Pathways for CDC25A
        Phosphatases
    Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CDC25A (see all 8)
        Cell cycle Role of APC in cell cycle regulation
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)

    Selected BioSystems Pathways for CDC25A (see all 11)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    miRNAs involved in DDR
    Integrated Breast Cancer Pathway


    Selected Reactome Pathways for CDC25A (see all 12)
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    Activation of ATR in response to replication stress
    G0 and Early G1
    E2F-enabled inhibition of pre-replication complex formation
    Cyclin E associated events during G1/S transition


    3 Kegg Pathways  (Kegg details for CDC25A):
        Cell cycle
    Progesterone-mediated oocyte maturation
    MicroRNAs in cancer


    CDC25A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25A: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC25A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC25A (P303041, 2, 3 ENSP000003037064) via UniProtKB, MINT, STRING, and/or I2D (see all 305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-49914 MINT-49900 MINT-49902 I2D: score=5 STRING: ENSP00000359206
    YWHAEP622582, 3, ENSP000002643354MINT-19304 MINT-19397 MINT-19303 I2D: score=5 STRING: ENSP00000264335
    CHEK2O960172, 3, ENSP000003720234MINT-17354 MINT-15591 I2D: score=4 STRING: ENSP00000372023
    YWHAQP273482, 3, ENSP000002380814MINT-8008839 I2D: score=2 STRING: ENSP00000238081
    YWHAZP631041, 2, 3, ENSP000003095034EBI-747671,EBI-347088 MINT-3294407 MINT-3294794 I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS11139144
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000087mitotic M phase ----
    GO:0000278mitotic cell cycle TAS--

    CDC25A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDC25A
      Browse compounds at ApexBio 

    Compounds for CDC25A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor[93718-83-3]

    2 HMDB Compounds for CDC25A    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for CDC25A gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzamide riboside 70 2 11966440 (1), 10467347 (1)
    se-methylselenocysteine 52.5 2 15213307 (1), 16518418 (1)
    tyrosine 50.4 24 9989807 (3), 12679193 (1), 16809424 (1), 15209522 (1) (see all 22)
    camptothecin 46.7 3 16928871 (2), 12676925 (1)
    threonine 39.6 3 11804965 (1), 19075567 (1), 20368335 (1)
    artesunate 39.2 1 12869643 (1)
    arsenite 34.9 7 17545210 (6)
    roscovitine 33.3 2 11752153 (1), 12801928 (1)
    bpde 33.2 3 16912045 (2), 17602818 (1)
    fudr 27.5 9 15374972 (4), 16931916 (2)



    CDC25A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC25A gene (2 alternative transcripts): 
    NM_001789.2  NM_201567.1  

    Unigene Cluster for CDC25A:

    Cell division cycle 25A
    Hs.437705  [show with all ESTs]
    Unigene Representative Sequence: NM_001789
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302506(uc003csh.1) ENST00000351231(uc003csi.1 uc021wxk.1)
    ENST00000459900 ENST00000443342 ENST00000437972
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDC25A (see all 70):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-371-5p hsa-miR-93 hsa-miR-29a*
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC25A (NM_001789)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC25A
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CDC25A
      QuantiFast Probe-based Assays in human, mouse, rat CDC25A

    Additional mRNA sequence: 

    AF277722.1 AK290554.1 AY137580.1 BC007401.2 BC018642.2 EU812118.1 FJ866789.1 M81933.1 

    6 DOTS entries:

    DT.209227  DT.306884  DT.92428522  DT.75100887  DT.120889888  DT.92064783 

    Selected AceView cDNA sequences (see all 112):

    BQ883064 AI917350 BQ065803 BF968769 AW139217 BF221494 BQ689872 NM_201567 
    NM_001789 BM971031 AI800535 AY137580 AA648922 AW235354 BU631902 BU149531 
    BC007401 AI671182 BX114416 BE409135 BM715615 BC018642 BE298834 BE781399 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC25A (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                                          
    SP2:                                                                          -                                                               
    SP3:                                                                          -                                                               
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CDC25A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDC25A expression in normal human tissues (normalized intensities)      CDC25A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDC25A Expression
    About this image


    CDC25A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Biliary Epithelial Cells Intrahepatic Biliary Tree
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Biliary Epithelial Cells Intrahepatic Biliary Tree
    CDC25A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC25A Protein Expression

    Genevestigator expression for CDC25A

    SOURCE GeneReport for Unigene cluster: Hs.437705
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC25A: 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC25A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC25A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc25a1 , 5 cell division cycle 25 homolog A (S. pombe)5
    cell division cycle 25A1
    85.83(n)1
    85.96(a)1
      9 (59.81 cM)5
    125301  NM_007658.31  NP_031684.31 
     1098755795 
    chicken
    (Gallus gallus)
    Aves CDC25A1 cell division cycle 25 homolog A (S. pombe) 67.65(n)
    65.16(a)
      420375  NM_001199572.1  NP_001186501.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    40(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038835(63-10242)
    GL343332.1(1327009-1338030)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981412 tyrosine phosphatase Cdc25A 73.19(n)    AF090829.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc252 cdc25 77.94(n)   57925  AF212941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stg3 protein amino acid dephosphorylation
    protein tyrosine more
    47(a)
    (best of 2)
      3 99A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-25.46
    cdc-25.36
    (see all 4)
    Protein CDC-25.3 (cdc-25.3) mRNA, complete cds
    (see all 4)
    26(a)
    24(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(10188310-10189405) WBGene00000389
    III(8916417-8917929) WBGene00000388
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIH16
    Protein tyrosine phosphatase involved in cell cycl...
    19(a)
    1 → many
    XIII(341856-343520) YMR036C


    ENSEMBL Gene Tree for CDC25A (if available)
    TreeFam Gene Tree for CDC25A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC25A gene
    CDC25B2  CDC25C2  
    3 SIMAP similar genes for CDC25A using alignment to 4 protein entries:     MPIP1_HUMAN (see all proteins):
    DKFZp686G14213    CDC25B    CDC25C

    CDC25A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDC25A (see all 646)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111301581,2
    C,F,A,H--48198300(+) CATACC/ATAAAG 2 -- ds500113Minor allele frequency- A:0.32NA EA WA CSA 869
    rs170799981,2
    C,F,H--48198311(+) GACCAT/CGTGTT 2 -- ds50019Minor allele frequency- C:0.06NA NS CSA 934
    rs1436970861,2
    --48198327(+) TTCTGA/GGCGTC 2 -- ds50010--------
    rs67631391,2
    C,F,A--48198455(+) aatgcG/Agggat 2 -- ds50011Minor allele frequency- A:0.30WA 118
    rs1892048171,2
    --48198470(+) AGCATA/GAGCCA 2 -- ds50010--------
    rs1480990091,2
    --48198524(+) TTGCAA/GATCAA 2 -- ds50010--------
    rs1409293231,2
    C--48198906(+) AAACCC/TGTAAC 2 -- ut310--------
    rs1502741721,2
    --48198932(+) CTCCAA/GTATCA 2 -- ut310--------
    rs1810813901,2
    --48199168(+) ACAACC/TGGTGA 2 -- ut310--------
    rs1161193781,2
    C,F--48199175(+) GTGATG/AATTCA 2 -- ut311Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for CDC25A (48198636 - 48229892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDC25A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834682CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC25A
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC25A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 116947    OMIM disorders: --

    Selected diseases for CDC25A (see all 42):    About MalaCards
    pandas    cutaneous malignant melanoma    spermatogenic failure    ataxia telangiectasia
    eye disease    non-hodgkin lymphoma    anaplastic large cell lymphoma    polycystic kidney disease
    kidney disease    azoospermia    retinoblastoma    hodgkin's lymphoma
    lung cancer susceptibility    ataxia    esophageal cancer    hepatocellular carcinoma
    esophagitis    myeloid leukemia    oral squamous cell carcinoma    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for CDC25A:
    Cancer

    CDC25A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CDC25A gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 55.6 4 15028555 (2), 16440198 (1), 17111124 (1)
    ataxia telangiectasia 55.2 6 19062161 (1), 17431115 (1), 17015478 (1), 17172433 (1)
    cancer 47.5 42 18167338 (2), 18794133 (2), 19738433 (1), 10754492 (1) (see all 30)
    indolent lymphoma 40 2 10754492 (2)
    tumors 37.6 47 9751615 (3), 10995786 (2), 17111124 (2), 16818510 (2) (see all 25)
    neoplastic transformation 29.2 1 17361412 (1)
    breast cancer 29.1 25 18665474 (4), 14603247 (3), 16598773 (3), 10995786 (2) (see all 12)
    carcinoma squamous cell 23.2 5 11487274 (2), 17111124 (1), 18792900 (1), 9192810 (1)
    mammary tumor 21.8 2 19075565 (1)
    prostate cancer 19.6 8 19013180 (4), 14673957 (1), 14652289 (1)

    Genetic Association Database (GAD): CDC25A
    Human Genome Epidemiology (HuGE) Navigator: CDC25A (11 documents)

    Export disorders for CDC25A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC25A gene, integrated from 10 sources (see all 333):
    (articles sorted by number of sources associating them with CDC25A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)1, 2, 3, 9 Galaktionov K.I. and Beach D. (Cell 1991)
    2. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PubMed id 20228808)1, 2, 9 Pereg Y.... Dixit V.M. (Nat. Cell Biol. 2010)
    3. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. (PubMed id 12676925)1, 2, 9 Xiao Z.... Zhang H. (J. Biol. Chem. 2003)
    4. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. (PubMed id 20090422)1, 2, 9 Soerensen C.S.... Helin K. (Cell Cycle 2010)
    5. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. (PubMed id 12759351)1, 2, 9 Hassepass I.... Hoffmann I. (J. Biol. Chem. 2003)
    6. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. (PubMed id 11298456)1, 2, 9 Falck J.... Lukas J. (Nature 2001)
    7. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. (PubMed id 12399544)1, 2, 9 Zhao H.... Piwnica-Worms H. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. (PubMed id 14559997)1, 2, 9 Chen M.-S.... Piwnica-Worms H. (Mol. Cell. Biol. 2003)
    9. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. (PubMed id 9604936)1, 2, 9 Fauman E.B.... Saper M.A. (Cell 1998)
    10. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 993 HGNC: 1725 AceView: CDC25A Ensembl:ENSG00000164045 euGenes: HUgn993
    ECgene: CDC25A Kegg: 993 H-InvDB: CDC25A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC25A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC25A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc25a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC25A gene:
    Search GeneIP for patents involving CDC25A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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