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CDC23 Gene

protein-coding   GIFtS: 62
GCID: GC05M137552

Cell Division Cycle 23

(Previous names: CDC23 (cell division cycle 23, yeast, homolog), cell division...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 231 2     CDC23 (Cell Division Cycle 23, Yeast, Homolog)1
APC82 3 5     Cell Division Cycle 23 Homolog (S. Cerevisiae)1
Anaphase Promoting Complex Subunit 81 2     CUT232
Anaphase-Promoting Complex Subunit 82 3     Cell Division Cycle 23 Homolog2
Cyclosome Subunit 82 3     Cell Division Cycle Protein 23 Homolog2
ANAPC82 3     

External Ids:    HGNC: 17241   Entrez Gene: 86972   Ensembl: ENSG000000948807   OMIM: 6034625   UniProtKB: Q9UJX23   

Export aliases for CDC23 gene to outside databases

Previous GC identifers: GC05M137398 GC05M138198 GC05M137554 GC05M137599 GC05M132714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC23 Gene:
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential
for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex
(APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the
formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type
cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a
protein domain important for protein-protein interaction. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC23 Gene:
CDC23 (cell division cycle 23) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for CDC23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC23 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-1   E2F-2   E2F   E2F-1   Nkx6-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC23 promoter sequence
   Search Chromatin IP Primers for CDC23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

CDC23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC23 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137552:  view genomic region     (about GC identifiers)

Start:
137,523,337 bp from pter      End:
137,549,032 bp from pter
Size:
25,696 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2 (See protein sequence)
Recommended Name: Cell division cycle protein 23 homolog  
Size: 597 amino acids; 68834 Da
Subunit: The APC/C is composed of at least 12 subunits
Sequence caution: Sequence=AAC70920.1; Type=Erroneous initiation; Sequence=AAH05258.1; Type=Erroneous initiation;
Sequence=AAH10944.1; Type=Erroneous initiation; Sequence=AAH17713.1; Type=Erroneous initiation;
Sequence=AAS99353.1; Type=Erroneous initiation; Sequence=BAA75628.1; Type=Erroneous initiation;
Sequence=BAD96970.1; Type=Erroneous initiation; Sequence=BAF84299.1; Type=Erroneous initiation;
Secondary accessions: A8K6E5 B4E3A2 B7WP05 D3DQB7 O75433 Q53FN2 Q9BS73
Alternative splicing: 3 isoforms:  Q9UJX2-1   Q9UJX2-2   Q9UJX2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC23: NX_Q9UJX2

Explore proteomics data for CDC23 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis1
  • Ubiquitination2 at Lys445, Lys453, Lys467, Lys547
  • Modification sites at PhosphoSitePlus

  • See CDC23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004652.2  
    ENSEMBL proteins: 
     ENSP00000378350   ENSP00000422505   ENSP00000422902   ENSP00000378348   ENSP00000423704  
    Reactome Protein details: Q9UJX2

    CDC23 Human Recombinant Protein Products:

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    antibodies-online peptides for CDC23

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR007192 APC8
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UJX2

    ProtoNet protein and cluster: Q9UJX2

    UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2
    Similarity: Belongs to the APC8/CDC23 family
    Similarity: Contains 9 TPR repeats


    Find genes that share domains with CDC23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC23_HUMAN, Q9UJX2
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Genatlas biochemistry entry for CDC23:
    cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin
    mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of
    this disease

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS12629511
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CDC23           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDC23:
     Increased cell death HMECs cel  Increased cell death in breast  Increased cell number in S 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDC23

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    Block miRNA regulation of human, mouse, rat CDC23 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC23 (see all 43):
    hsa-miR-302d hsa-miR-520e hsa-miR-3616-5p hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-9 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCDC23 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum2
    extracellular2
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA14657031
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CDC23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC23 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with CDC23           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC23 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for CDC23 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for CDC23
        TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for CDC23 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for CDC23):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including CDC23: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDC23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC23 (Q9UJX22, 3 ENSP000003783504) via UniProtKB, MINT, STRING, and/or I2D (see all 954)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=9 STRING: ENSP00000348554
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000339109
    BUB3O436842, 3, ENSP000003578584MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000357858
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=7 STRING: ENSP00000314004
    RBPMSQ930622, 3, ENSP000003401764MINT-66993 I2D: score=5 STRING: ENSP00000340176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080mitotic G1 phase IDA12629511
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9790767
    GO:0007049cell cycle TAS12188893
    GO:0007067mitosis IDA14657031

    Find genes that share ontologies with CDC23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for CDC23



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC23 gene: 
    NM_004661.3  

    Unigene Cluster for CDC23:

    Cell division cycle 23
    Hs.73625  [show with all ESTs]
    Unigene Representative Sequence: NM_004661
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394886(uc003lcl.3) ENST00000464806 ENST00000475021 ENST00000471692
    ENST00000482948 ENST00000483961 ENST00000511383 ENST00000394884(uc003lcm.1)
    ENST00000505120
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    hsa-miR-302d hsa-miR-520e hsa-miR-3616-5p hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-9 hsa-miR-424
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    Additional mRNA sequence: 

    AB011472.1 AF053977.1 AF191341.1 AK223250.1 AK291610.1 AK304635.1 BC005258.1 BC010944.1 
    BC017713.1 BT009810.1 

    12 DOTS entries:

    DT.100892231  DT.100689547  DT.99969393  DT.95288172  DT.40299148  DT.95281853  DT.95083029  DT.455370 
    DT.120861041  DT.440036  DT.95288174  DT.120861111 

    Selected AceView cDNA sequences (see all 227):

    BX370524 R34844 T32537 BX375648 AI589569 BX375713 BX490275 BQ718238 
    NM_004661 BC010944 BU621657 AA779421 BM698439 BC017713 BU069261 AA329578 
    BC005258 BX499138 AA304532 BM023346 AI538321 AW963198 BI087816 AI765871 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                      -     -     -                                                           -     -                 -                     
    SP2:                                      -     -     -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     
    SP5:                                      -     -                                                                                                               

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CDC23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCAGAATG
    CDC23 Expression
    About this image

    CDC23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73625
        Pathway & Disease-focused RT2 Profiler PCR Array including CDC23: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC23 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc231 , 5 CDC23 (cell division cycle 23, yeast, homolog)5
    CDC23 cell division cycle 231
    88.55(n)1
    95.48(a)1
      18 (18.69 cM)5
    525631  NM_178347.41  NP_848124.11 
     346309515 
    chicken
    (Gallus gallus)
    Aves CDC231 cell division cycle 23 homolog (S. cerevisiae) 80.29(n)
    92.35(a)
      771857  XM_003642103.2  XP_003642151.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC236
    cell division cycle 23
    89(a)
    1 ↔ 1
    2(146326984-146341225)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042346.12   -- 78.49(n)    BC042346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560132 similar to CDC23 (cell division cycle 23, yeast, homolog) 73(n)   393907  BC045861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG25083
    cdc231
    mitotic anaphase ubiquitin-protein
    ligase3
    cdc231
    48(a)3
    54.75(n)1
    50.67(a)1
      353151  NM_001273700.11  NP_001260629.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mat-33   -- 36(a)   III -27.020000   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC231 CDC23 47.2(n)
    38.45(a)
      856571   NP_012036.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC81 APC8 53.55(n)
    46.99(a)
      823970  NM_114684.4  NP_190398.1 
    rice
    (Oryza sativa)
    Liliopsida Os.226242 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.3(n)    AK070096.1 


    ENSEMBL Gene Tree for CDC23 (if available)
    TreeFam Gene Tree for CDC23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC23 (see all 551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146452671,2
    C,F--137524027(+) GATTAT/CTTTTG 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1390491611,2
    --137524088(+) CTTTAC/GAAGAC 1 -- ut310--------
    rs1838280971,2
    --137524287(+) TAGAGG/TGGCAG 1 -- ut310--------
    rs1885516761,2
    --137524310(+) TCTTTA/CACTCT 1 -- ut310--------
    rs172349471,2
    C,F--137524314(-) GCTGAG/CAGTGA 1 -- ut311Minor allele frequency- C:0.01NS 160
    rs18022921,2
    --137524486(-) CAGGAA/TCAGAC 1 -- ut310--------
    rs1401815101,2
    --137524503(+) TTCTGG/TCAGTT 1 -- ut310--------
    rs1807308661,2
    C--137524594(+) ACAGAC/TGTGCT 1 -- ut310--------
    rs1861376691,2
    C--137524655(+) GGCTTA/GAGAGT 1 -- ut310--------
    rs1919029941,2
    C--137524728(+) TAGCAG/TAGAGT 2 Y S mis10--------

    HapMap Linkage Disequilibrium report for CDC23 (137523337 - 137549032 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDC23:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670577CNV Deletion23128226
    nsv882937CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC23
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603462    OMIM disorders: --


    Find genes that share disorders with CDC23           About GenesLikeMe


    Export disorders for CDC23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC23 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with CDC23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PubMed id 9790767)1, 2, 3, 9 Zhao N....Le Beau M.M. (Genomics 1998)
    2. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    7. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2 Yu H.... Kirschner M.W. (Science 1998)
    8. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 9 Walker M.G. (Curr. Cancer Drug Targets 2001)
    9. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8697 HGNC: 1724 AceView: CDC23 Ensembl:ENSG00000094880 euGenes: HUgn8697
    ECgene: CDC23 Kegg: 8697 H-InvDB: CDC23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC23 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc23/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC23 gene:
    Search GeneIP for patents involving CDC23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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