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Aliases for CDC23 Gene

Aliases for CDC23 Gene

  • Cell Division Cycle 23 2 3 5
  • Anaphase Promoting Complex Subunit 8 2 3
  • Anaphase-Promoting Complex Subunit 8 3 4
  • Cyclosome Subunit 8 3 4
  • ANAPC8 3 4
  • APC8 3 4
  • CDC23 (Cell Division Cycle 23, Yeast, Homolog) 2
  • Cell Division Cycle 23 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle 23 Homolog 3
  • CUT23 3

External Ids for CDC23 Gene

Previous GeneCards Identifiers for CDC23 Gene

  • GC05M137398
  • GC05M137554
  • GC05M137599
  • GC05M137552
  • GC05M132714

Summaries for CDC23 Gene

Entrez Gene Summary for CDC23 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC23 Gene

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Mitotic Metaphase and Anaphase. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for CDC23 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC23 Gene

Genomics for CDC23 Gene

Regulatory Elements for CDC23 Gene

Enhancers for CDC23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC23 on UCSC Golden Path with GeneCards custom track

Promoters for CDC23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC23 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC23 Gene

Chromosome:
5
Start:
138,187,648 bp from pter
End:
138,213,343 bp from pter
Size:
25,696 bases
Orientation:
Minus strand

Genomic View for CDC23 Gene

Genes around CDC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC23 Gene

Proteins for CDC23 Gene

  • Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX2-CDC23_HUMAN
    Recommended name:
    Cell division cycle protein 23 homolog
    Protein Accession:
    Q9UJX2
    Secondary Accessions:
    • A8K6E5
    • B4E3A2
    • B7WP05
    • D3DQB7
    • O75433
    • Q53FN2
    • Q9BS73

    Protein attributes for CDC23 Gene

    Size:
    597 amino acids
    Molecular mass:
    68834 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC23 Gene

    Alternative splice isoforms for CDC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC23 Gene

Proteomics data for CDC23 Gene at MOPED

Post-translational modifications for CDC23 Gene

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Ubiquitination at Lys 445, Lys 453, and Lys 547
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC23 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC23 (CDC23)
  • Abcam antibodies for Cdc23

No data available for DME Specific Peptides for CDC23 Gene

Domains & Families for CDC23 Gene

Protein Domains for CDC23 Gene

Suggested Antigen Peptide Sequences for CDC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX2

UniProtKB/Swiss-Prot:

CDC23_HUMAN :
  • Belongs to the APC8/CDC23 family.
  • Contains 13 TPR repeats.
Family:
  • Belongs to the APC8/CDC23 family.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with CDC23: view

Function for CDC23 Gene

Molecular function for CDC23 Gene

GENATLAS Biochemistry:
cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease
UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 12629511
genes like me logo Genes that share ontologies with CDC23: view
genes like me logo Genes that share phenotypes with CDC23: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC23 Gene

Localization for CDC23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC23 Gene COMPARTMENTS Subcellular localization image for CDC23 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 2
extracellular 2
cytoskeleton 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CDC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDC23 Gene

Pathways & Interactions for CDC23 Gene

SuperPathways for CDC23 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Antigen processing- Ubiquitination and Proteasome degradation
4 Cell Cycle, Mitotic
.61
5 Cellular Senescence
genes like me logo Genes that share pathways with CDC23: view

UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC23 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IDA 14657031
GO:0007080 mitotic metaphase plate congression IDA 14657031
GO:0007091 metaphase/anaphase transition of mitotic cell cycle TAS 9790767
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0007096 regulation of exit from mitosis TAS 9790767
genes like me logo Genes that share ontologies with CDC23: view

Drugs & Compounds for CDC23 Gene

No Compound Related Data Available

Transcripts for CDC23 Gene

Unigene Clusters for CDC23 Gene

Cell division cycle 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CDC23 Gene

GeneLoc Exon Structure for
CDC23
ECgene alternative splicing isoforms for
CDC23

Expression for CDC23 Gene

mRNA expression in normal human tissues for CDC23 Gene

Protein differential expression in normal tissues from HIPED for CDC23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (53.2) and Breast (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC23 Gene



SOURCE GeneReport for Unigene cluster for CDC23 Gene Hs.73625

genes like me logo Genes that share expression patterns with CDC23: view

Protein tissue co-expression partners for CDC23 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC23 Gene

Orthologs for CDC23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC23 35
  • 92.91 (n)
  • 97.32 (a)
CDC23 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC23 35
  • 92.41 (n)
  • 98.66 (a)
CDC23 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc23 35
  • 88.55 (n)
  • 95.48 (a)
Cdc23 16
Cdc23 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC23 35
  • 99.66 (n)
  • 99.83 (a)
CDC23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc23 35
  • 88.67 (n)
  • 95.64 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC23 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC23 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC23 35
  • 80.29 (n)
  • 92.35 (a)
CDC23 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC23 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc23 35
  • 77.62 (n)
  • 90.56 (a)
Str.8410 35
zebrafish
(Danio rerio)
Actinopterygii cdc23 35
  • 71.33 (n)
  • 80.94 (a)
zgc56013 35
cdc23 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2508 37
  • 48 (a)
cdc23 35
  • 54.75 (n)
  • 50.67 (a)
cdc23 36
  • 40 (a)
OneToMany
CG31687 36
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009880 35
  • 52.89 (n)
  • 49.82 (a)
worm
(Caenorhabditis elegans)
Secernentea mat-3 37
  • 36 (a)
mat-3 36
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR206W 35
  • 47.97 (n)
  • 39.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05258g 35
  • 49.92 (n)
  • 40.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC23 35
  • 47.2 (n)
  • 38.45 (a)
CDC23 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons APC8 35
  • 53.55 (n)
  • 46.99 (a)
rice
(Oryza sativa)
Liliopsida Os.22624 35
Os02g0656300 35
  • 55.71 (n)
  • 50.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5916 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01174 35
  • 49.33 (n)
  • 43.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut23 35
  • 48.73 (n)
  • 42.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8976 36
  • 43 (a)
OneToOne
Species with no ortholog for CDC23:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC23 Gene

ENSEMBL:
Gene Tree for CDC23 (if available)
TreeFam:
Gene Tree for CDC23 (if available)

Paralogs for CDC23 Gene

No data available for Paralogs for CDC23 Gene

Variants for CDC23 Gene

Sequence variations from dbSNP and Humsavar for CDC23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17228304 - 138,212,993(-) TTACA(C/G)AGGTA reference, missense
rs2231471 - 138,213,287(-) GGTCC(A/C/G/T)GGTGG reference, missense
rs2906124 -- 138,193,146(+) TGGTC(A/G/T)CAAAC intron-variant
rs2906125 -- 138,197,388(+) AAGAT(A/G)GCAAA intron-variant
rs2906126 -- 138,197,389(+) AGATG(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC23 Gene

Variant ID Type Subtype PubMed ID
nsv882937 CNV Loss 21882294
esv2670577 CNV Deletion 23128226

Variation tolerance for CDC23 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDC23 Gene

Disorders for CDC23 Gene

Relevant External Links for CDC23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC23

No disorders were found for CDC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC23 Gene

Publications for CDC23 Gene

  1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N. … Le Beau M.M. (Genomics 1998) 2 3 4 23 67
  2. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 3 23
  3. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  4. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CDC23 Gene

Sources for CDC23 Gene

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