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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC23 Gene

protein-coding GIFtS: 60
GCID: GC05M137552

cell division cycle 23

(Previous names: CDC23 (cell division cycle 23, yeast, homolog), cell division...)

Explore 4 diseases affiliated with
CDC23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 23¹ ²		CDC23 (Cell Division Cycle 23, Yeast, Homolog)¹
APC8¹ ² ³ ⁵		Cell Division Cycle 23 Homolog (S. Cerevisiae)¹
ANAPC8¹ ² ³		Anaphase Promoting Complex Subunit 8²
CUT23¹ ²		Cell Division Cycle 23 Homolog²
Anaphase-Promoting Complex Subunit 8² ³		Cell Division Cycle Protein 23 Homolog²
Cyclosome Subunit 8² ³

External Ids:	HGNC: 1724¹	Entrez Gene: 8697²	Ensembl: ENSG00000094880⁷	OMIM: 603462⁵	UniProtKB: Q9UJX2³

Export aliases for CDC23 gene to outside databases

Previous GC identifers: GC05M137398 GC05M138198 GC05M137554 GC05M137599 GC05M132714

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC23:

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for

cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC),

which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of

cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This

protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important

for protein-protein interaction. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for CDC23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC23 gene promoter:
E2F-3a E2F-4 E2F-5 AP-1 E2F-2 E2F E2F-1 Nkx6-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC23 promoter sequence

Search SABiosciences Chromatin IP Primers for CDC23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31

CDC23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC23 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M137552: view genomic region (about GC identifiers)

Start:	137,523,337 bp from pter	End:	137,549,032 bp from pter
Size:	25,696 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2 (See protein sequence)

Recommended Name: Cell division cycle protein 23 homolog

Size: 597 amino acids; 68834 Da

Subunit: The APC/C is composed of at least 12 subunits

Sequence caution: Sequence=AAC70920.1; Type=Erroneous initiation; Sequence=AAH05258.1; Type=Erroneous initiation;

Sequence=AAH10944.1; Type=Erroneous initiation; Sequence=AAH17713.1; Type=Erroneous initiation; Sequence=AAS99353.1;

Type=Erroneous initiation; Sequence=BAA75628.1; Type=Erroneous initiation; Sequence=BAD96970.1; Type=Erroneous

initiation; Sequence=BAF84299.1; Type=Erroneous initiation;

Secondary accessions: A8K6E5 B4E3A2 B7WP05 D3DQB7 O75433 Q53FN2 Q9BS73

Alternative splicing: 3 isoforms: Q9UJX2-1 Q9UJX2-2 Q9UJX2-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC23: NX_Q9UJX2

Post-translational modifications:

Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJX2

CDC23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004652.2

ENSEMBL proteins:

ENSP00000378350 ENSP00000422505 ENSP00000422902 ENSP00000378348 ENSP00000423704

Reactome Protein details: Q9UJX2
Human Recombinant Protein Products for CDC23:

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	Novus Biologicals CDC23 Proteins Novus Biologicals CDC23 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC23

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	anaphase-promoting complex	IDA	--
GO:0005829	cytosol	TAS	--

CDC23 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CDC23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC23 for domains About GeneDecksing

5 InterPro domains/families:

IPR011990 TPR-like_helical

IPR001440 TPR-1

IPR007192 APC8

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q9UJX2

ProtoNet protein and cluster: Q9UJX2

UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2

Similarity: Belongs to the APC8/CDC23 family

Similarity: Contains 9 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDC23_HUMAN, Q9UJX2

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Genatlas biochemistry entry for CDC23:

cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin

mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this

disease

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	12629511

CDC23 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CDC23:

Increased cell death HMECs cel

Increased cell death in breast

Increased cell number in S

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDC23

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		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC23 (see all 43):
		hsa-miR-302d hsa-miR-520e hsa-miR-3616-5p hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-9 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: CDC23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC23

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/15 pathways (see all 15)
APC/C:Cdh1-mediated degradation of Skp2	0.74	APC/C:Cdc20 mediated degradation of mitotic proteins	0.69
APC/C:Cdc20 mediated degradation of Securin	0.74	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69
Degradation of multiubiquitinated Securin	0.74	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68
Autodegradation of Cdh1 by Cdh1:APC/C	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62

APC-Cdc20 mediated degradation of Nek2A

8/10 pathways (see all 10)
Degradation of multiubiquitinated Nek2A	1.00	Degradation of multiubiquitinated Cyclin B	0.76
APC-Cdc20 mediated degradation of Nek2A	1.00	Mitotic Spindle Checkpoint	0.75
Inactivation of APC/C via direct inhibition of the APC/C complex	0.78	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.60
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.78	Phosphorylation of the APC/C	0.54

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for CDC23 (see all 9)

	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Signal transduction PKA signaling

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDC23 (see all 6)

	Activation of PKA through GPCR
	Remodeling of Adherens Junctions
	cAMP Pathway
	CDC42 Pathway
	Mitotic Roles of Polo Like Kinases

5/7 GeneGo (Thomson Reuters) Pathways for CDC23 (see all 7)

	Cell cycle Role of APC in cell cycle regulation
	G-protein signaling G-Protein alpha-s signaling cascades
	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Spindle assembly and chromosome separation

1 BioSystems Pathway for CDC23

TGF-beta Receptor Signaling Pathway

5/36 Reactome Pathways for CDC23 (see all 36)

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Antigen processing: Ubiquitination & Proteasome degradation

4 Kegg Pathways (Kegg details for CDC23):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis
	Progesterone-mediated oocyte maturation

UniProtKB/Swiss-Prot: CDC23_HUMAN, Q9UJX2

Pathway: Protein modification; protein ubiquitination

CDC23 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDC23

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/865 Interacting proteins for CDC23 (Q9UJX2^{2, 3} ENSP00000378350⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 865)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7945693 MINT-7947479 I2D: score=9 STRING: ENSP00000348554
ANAPC1	Q9H1A4²^,³, ENSP00000339109⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000339109
BUB3	O43684²^,³, ENSP00000357858⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000357858
ANAPC2	Q9UJX6²^,³, ENSP00000314004⁴	MINT-7947479 I2D: score=7 STRING: ENSP00000314004
RBPMS	Q93062²^,³, ENSP00000340176⁴	MINT-66993 I2D: score=5 STRING: ENSP00000340176

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000080	G1 phase of mitotic cell cycle	IDA	12629511
GO:0000278	mitotic cell cycle	TAS	--
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	9790767
GO:0007049	cell cycle	TAS	12188893

CDC23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC23
Search CenterWatch for drugs/clinical trials and news about CDC23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC23 gene:

NM_004661.3

Unigene Cluster for CDC23:

Cell division cycle 23 homolog (S. cerevisiae)

Hs.73625 [show with all ESTs]

Unigene Representative Sequence: NM_004661

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394886(uc003lcl.3) ENST00000464806 ENST00000475021 ENST00000471692

ENST00000482948 ENST00000483961 ENST00000511383 ENST00000394884(uc003lcm.1)

ENST00000505120

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		hsa-miR-302d hsa-miR-520e hsa-miR-3616-5p hsa-miR-4272 hsa-miR-15a hsa-miR-106a hsa-miR-9 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: CDC23 3' UTR sequence

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Additional cDNA sequence:

AB011472.1 AF053977.1 AF191341.1 AK223250.1 AK291610.1 AK304635.1 BC005258.1 BC010944.1

BC017713.1 BT009810.1

12 DOTS entries:

DT.100892231 DT.100689547 DT.99969393 DT.95288172 DT.40299148 DT.95281853 DT.95083029 DT.455370

DT.120861041 DT.440036 DT.95288174 DT.120861111

24/227 AceView cDNA sequences (see all 227):

AW182914 BP377135 BX101386 BQ718238 BI087816 AA329578 Z38892 AA779421

BM698439 AI589569 AB011472 BU069261 CF126203 AI765871 BX490275 AI538321

BX375713 BF477745 T32537 BX375648 AW963198 BC017713 BU621657 BT009810

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	^
SP1:													-		-		-																				-		-						-
SP2:													-		-		-
SP3:
SP4:																																													-
SP5:													-		-

ExUns:	17a	·	17b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CDC23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCAGAATG

About this image
See CDC23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC23

SOURCE GeneReport for Unigene cluster: Hs.73625
SABiosciences Expression via Pathway-Focused PCR Array including CDC23:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC23

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdc23^{1 , 5}	CDC23 (cell division cycle 23, yeast, homolog)⁵ CDC23 cell division cycle 23¹	88.55(n)¹ 95.48(a)¹		18 (18.69 cM)⁵ 52563¹ NM_178347.4¹ NP_848124.1¹ 34630951⁵
chicken (Gallus gallus)	Aves	CDC23¹	cell division cycle 23 homolog (S. cerevisiae)	79.91(n) 91.61(a)		771857 XM_003642103.1 XP_003642151.1
lizard (Anolis carolinensis)	Reptilia	CDC23⁶	--	89(a)	1 ↔ 1	2(146330297-146341189)
African clawed frog (Xenopus laevis)	Amphibia	BC042346.1²	--	78.49(n)		BC042346.1
zebrafish (Danio rerio)	Actinopterygii	zgc56013²	similar to CDC23 (cell division cycle 23, yeast, homolog)	73(n)		393907 BC045861.1
fruit fly (Drosophila melanogaster)	Insecta	CG2508³ cdc23¹	mitotic anaphase ubiquitin-protein ligase³ CG2508-PA¹	48(a)³ 54.62(n)¹ 50.67(a)¹		35315¹ NM_136192.2¹ NP_610036.2¹
worm (Caenorhabditis elegans)	Secernentea	mat-3³	--	36(a)		III -27.020000 --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC23¹	Cdc23p	46.85(n) 38.24(a)		856571 NP_012036.1
thale cress (Arabidopsis thaliana)	eudicotyledons	APC8¹	anaphase-promoting complex subunit 8	53.55(n) 46.99(a)		823970 NM_114684.4 NP_190398.1
rice (Oryza sativa)	Liliopsida	Os.22624²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	70.3(n)		AK070096.1

ENSEMBL Gene Tree for CDC23 (if available)
TreeFam Gene Tree for CDC23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201144199^1,2		--	137523125(+)	`AGAGCA/GGTCAT`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs143544966^1,2		--	137523165(+)	`AAGAAA/CTAGGT`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs201817182^1,2		--	137523281(+)	`TGTTG-/TTTTTT`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs148122140^1,2		--	137523318(+)	`ACACAA/GAAACA`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs185083015^1,2		--	137523365(+)	`GAATTA/CCAAAT`	2	--	ut3¹		0	--	--	--	--
rs2864^1,2	C,F,O,A,H	--	137523430(-)	`CCAGAA/GTGATG`	2	--	ds500¹ ut3¹		31		MN NS NA EA CSA WA	3807
rs2863^1,2	C,F,H	--	137523438(+)	`TGGACC/AATGGG`	2	--	ut3¹ ds500¹ ese³		11		MN NS EA NA	1652
rs17228547^1,2	C,F,H	--	137523527(-)	`TAATAC/TGACTT`	2	--	ut3¹ ds500¹ ese³		11		NS NA	1872
rs190421542^1,2		--	137523559(+)	`TATAAA/GATGAA`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs150210709^1,2		--	137523673(+)	`TATTAC/TAGCAG`	2	--	ut3¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDC23 (137523337 - 137549032 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC23: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC23

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC23 for disorders           About GeneDecksing

OMIM gene information: 603462    OMIM disorders: --

4 diseases for CDC23:    About MalaCards

myeloid leukemia colon cancer leukemia neuronitis

Export disorders for CDC23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC23 gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with CDC23)

Utopia: connect your pdf to the dynamic
world of online information

Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PubMed id 9790767)^{1, 2, 3, 9} Zhao N....Le Beau M.M. (1998)
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)^{1, 2} Jin L....Rape M. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)^{1, 2} Dube P.... Stark H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)^{1, 2} Kraft C....Peters J.-M. (2003)
Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)^{1, 2} Yu H.... Kirschner M.W. (1998)
Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)^{1, 9} Walker M.G. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8697	HGNC: 1724	AceView: CDC23	Ensembl:ENSG00000094880	euGenes: HUgn8697
ECgene: CDC23	Kegg: 8697	H-InvDB: CDC23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC23	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc23/

Intellectual Property for CDC23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDC23 gene:
Search GeneIP for patents involving CDC23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cell division cycle 23

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cell division cycle 23

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