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Aliases for CDC23 Gene

Aliases for CDC23 Gene

  • Cell Division Cycle 23 2 3 5
  • Anaphase-Promoting Complex Subunit 8 3 4
  • Cyclosome Subunit 8 3 4
  • ANAPC8 3 4
  • APC8 3 4
  • CDC23 (Cell Division Cycle 23, Yeast, Homolog) 2
  • Cell Division Cycle 23 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 23 Homolog 3
  • Anaphase Promoting Complex Subunit 8 2
  • Cell Division Cycle 23 Homolog 3
  • CUT23 3

External Ids for CDC23 Gene

Previous GeneCards Identifiers for CDC23 Gene

  • GC05M137398
  • GC05M137554
  • GC05M137599
  • GC05M137552
  • GC05M132714

Summaries for CDC23 Gene

Entrez Gene Summary for CDC23 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC23 Gene

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and DNA Damage. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for CDC23 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC23 Gene

Additional gene information for CDC23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC23 Gene

Genomics for CDC23 Gene

Regulatory Elements for CDC23 Gene

Enhancers for CDC23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H138350 1.4 ENCODE dbSUPER 60.2 -140.0 -139992 4 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 CBX5 ZNF207 CDC23 BRD8 KDM3B HNRNPA0 FAM53C RPL7P19 FAM13B KIF20A GFRA3 REEP2
GH05H137833 1.8 FANTOM5 Ensembl ENCODE dbSUPER 46.1 +377.1 377128 5 PKNOX1 FOXA2 SIN3A FEZF1 GATA2 ATF7 FOS SP3 YY2 TSHZ1 CDC23 KDM3B HNRNPA0 MYOT FAM13B BRD8 RNU6-1148P KLHL3 PKD2L2 GC05M137818
GH05H138463 1.8 FANTOM5 ENCODE dbSUPER 42.5 -251.9 -251906 4 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 HNRNPA0 BRD8 CDC23 KDM3B EGR1 ETF1 FAM13B RPL7P19 FAM53C REEP2
GH05H138335 1.4 ENCODE dbSUPER 53.9 -124.2 -124198 5 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 HNRNPA0 KDM3B CDC23 RPL7P19 REEP2 MATR3 BRD8 NME5 SPOCK1 LRRTM2
GH05H137751 1.4 ENCODE dbSUPER 27.6 +459.9 459911 4 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN HNRNPA0 KDM3B CDC23 RPL7P19 ENSG00000232174 FAM13B NME5 PKD2L2 GC05M137746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC23 on UCSC Golden Path with GeneCards custom track

Promoters for CDC23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187464 -57 2000 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for CDC23 Gene

Chromosome:
5
Start:
138,187,648 bp from pter
End:
138,213,343 bp from pter
Size:
25,696 bases
Orientation:
Minus strand

Genomic View for CDC23 Gene

Genes around CDC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC23 Gene

Proteins for CDC23 Gene

  • Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX2-CDC23_HUMAN
    Recommended name:
    Cell division cycle protein 23 homolog
    Protein Accession:
    Q9UJX2
    Secondary Accessions:
    • A8K6E5
    • B4E3A2
    • B7WP05
    • D3DQB7
    • O75433
    • Q53FN2
    • Q9BS73

    Protein attributes for CDC23 Gene

    Size:
    597 amino acids
    Molecular mass:
    68834 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC23 Gene

    Alternative splice isoforms for CDC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC23 Gene

Post-translational modifications for CDC23 Gene

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Ubiquitination at Lys445, posLast=453453, and posLast=547547
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC23 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDC23 (CDC23)
  • Abcam antibodies for CDC23
  • Cloud-Clone Corp. Antibodies for CDC23
  • Santa Cruz Biotechnology (SCBT) Antibodies for CDC23

No data available for DME Specific Peptides for CDC23 Gene

Domains & Families for CDC23 Gene

Protein Domains for CDC23 Gene

Suggested Antigen Peptide Sequences for CDC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX2

UniProtKB/Swiss-Prot:

CDC23_HUMAN :
  • Belongs to the APC8/CDC23 family.
Family:
  • Belongs to the APC8/CDC23 family.
genes like me logo Genes that share domains with CDC23: view

Function for CDC23 Gene

Molecular function for CDC23 Gene

GENATLAS Biochemistry:
cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease
UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for CDC23 Gene

Gene Ontology (GO) - Molecular Function for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 12629511
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CDC23: view
genes like me logo Genes that share phenotypes with CDC23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDC23
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC23 Gene

Localization for CDC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC23 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex TAS,IDA 14657031
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CDC23 Gene

Pathways & Interactions for CDC23 Gene

SuperPathways for CDC23 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with CDC23: view

UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CDC23 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IDA 14657031
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9790767
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IDA 14657031
GO:0007091 metaphase/anaphase transition of mitotic cell cycle TAS 9790767
genes like me logo Genes that share ontologies with CDC23: view

Drugs & Compounds for CDC23 Gene

No Compound Related Data Available

Transcripts for CDC23 Gene

Unigene Clusters for CDC23 Gene

Cell division cycle 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDC23
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CDC23 Gene

GeneLoc Exon Structure for
CDC23
ECgene alternative splicing isoforms for
CDC23

Expression for CDC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC23 Gene

Protein differential expression in normal tissues from HIPED for CDC23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (53.2) and Breast (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC23 Gene



Protein tissue co-expression partners for CDC23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDC23 Gene:

CDC23

SOURCE GeneReport for Unigene cluster for CDC23 Gene:

Hs.73625

Evidence on tissue expression from TISSUES for CDC23 Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
  • Intestine(4.2)
  • Liver(4.2)
  • Stomach(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with CDC23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC23 Gene

Orthologs for CDC23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC23 33 34
  • 99.66 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC23 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC23 33 34
  • 92.91 (n)
dog
(Canis familiaris)
Mammalia CDC23 33 34
  • 92.41 (n)
rat
(Rattus norvegicus)
Mammalia Cdc23 33
  • 88.67 (n)
mouse
(Mus musculus)
Mammalia Cdc23 33 16 34
  • 88.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC23 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC23 33 34
  • 80.29 (n)
lizard
(Anolis carolinensis)
Reptilia CDC23 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc23 33
  • 77.62 (n)
Str.8410 33
zebrafish
(Danio rerio)
Actinopterygii cdc23 33 34
  • 71.33 (n)
zgc56013 33
fruit fly
(Drosophila melanogaster)
Insecta cdc23 33 34
  • 54.75 (n)
CG2508 35
  • 48 (a)
CG31687 34
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009880 33
  • 52.89 (n)
worm
(Caenorhabditis elegans)
Secernentea mat-3 35 34
  • 36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05258g 33
  • 49.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR206W 33
  • 47.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC23 33 34
  • 47.2 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC8 33
  • 53.55 (n)
rice
(Oryza sativa)
Liliopsida Os02g0656300 33
  • 55.71 (n)
Os.22624 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01174 33
  • 49.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut23 33
  • 48.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8976 34
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5916 33
Species where no ortholog for CDC23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC23 Gene

ENSEMBL:
Gene Tree for CDC23 (if available)
TreeFam:
Gene Tree for CDC23 (if available)

Paralogs for CDC23 Gene

No data available for Paralogs for CDC23 Gene

Variants for CDC23 Gene

Sequence variations from dbSNP and Humsavar for CDC23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000001862 -- 138,208,691(+) GATTA(C/T)ATAAT intron-variant
rs1000035697 -- 138,211,387(+) CAAAG(C/G)GTGAA intron-variant
rs1000101623 -- 138,201,280(+) CTATT(A/T)AATAG intron-variant
rs1000256745 -- 138,192,726(+) AGATA(G/T)CATTC intron-variant
rs1000370993 -- 138,202,067(+) AGTTT(A/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC23 Gene

Variant ID Type Subtype PubMed ID
esv2670577 CNV deletion 23128226
esv3606919 CNV loss 21293372

Variation tolerance for CDC23 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC23 Gene

Human Gene Mutation Database (HGMD)
CDC23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC23 Gene

Disorders for CDC23 Gene

Relevant External Links for CDC23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC23

No disorders were found for CDC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC23 Gene

Publications for CDC23 Gene

  1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N … Le Beau MM (Genomics 1998) 2 3 4 22 60
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 60
  3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 60
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 60

Products for CDC23 Gene

Sources for CDC23 Gene

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