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Aliases for CDC23 Gene

Aliases for CDC23 Gene

  • Cell Division Cycle 23 2 3
  • APC8 3 4 6
  • Anaphase Promoting Complex Subunit 8 2 3
  • Anaphase-Promoting Complex Subunit 8 3 4
  • Cyclosome Subunit 8 3 4
  • ANAPC8 3 4
  • CDC23 (Cell Division Cycle 23, Yeast, Homolog) 2
  • Cell Division Cycle 23 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 23 Homolog 3
  • Cell Division Cycle 23 Homolog 3
  • CUT23 3

External Ids for CDC23 Gene

Previous GeneCards Identifiers for CDC23 Gene

  • GC05M137398
  • GC05M137554
  • GC05M137599
  • GC05M137552
  • GC05M132714

Summaries for CDC23 Gene

Entrez Gene Summary for CDC23 Gene

  • The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC23 Gene

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for CDC23 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for CDC23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC23 Gene

Genomics for CDC23 Gene

Regulatory Elements for CDC23 Gene

Genomic Location for CDC23 Gene

Start:
138,187,648 bp from pter
End:
138,213,343 bp from pter
Size:
25,696 bases
Orientation:
Minus strand

Genomic View for CDC23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC23 Gene

Proteins for CDC23 Gene

  • Protein details for CDC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX2-CDC23_HUMAN
    Recommended name:
    Cell division cycle protein 23 homolog
    Protein Accession:
    Q9UJX2
    Secondary Accessions:
    • A8K6E5
    • B4E3A2
    • B7WP05
    • D3DQB7
    • O75433
    • Q53FN2
    • Q9BS73

    Protein attributes for CDC23 Gene

    Size:
    597 amino acids
    Molecular mass:
    68834 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAC70920.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH05258.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS99353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA75628.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96970.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC23 Gene

Proteomics data for CDC23 Gene at MOPED

Post-translational modifications for CDC23 Gene

  • Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
  • Ubiquitination at Lys445, Lys453, Lys467, and Lys547
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC23 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDC23 Gene

Domains for CDC23 Gene

Gene Families for CDC23 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for CDC23 Gene

Suggested Antigen Peptide Sequences for CDC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX2

UniProtKB/Swiss-Prot:

CDC23_HUMAN :
  • Q9UJX2
Family:
  • Belongs to the APC8/CDC23 family.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with CDC23: view

Function for CDC23 Gene

Molecular function for CDC23 Gene

GENATLAS Biochemistry: cell division cycle (CDC)23,S cerevisiae homolog,component of the anaphase promoting complex,involved in ubiquitin mediated proteolysis,commonly deleted in myeloid leukemias,but unlikely to be involved in the pathogenesis of this disease
UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 12629511
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CDC23: view
genes like me logo Genes that share phenotypes with CDC23: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC23 Gene

Localization for CDC23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC23 Gene COMPARTMENTS Subcellular localization image for CDC23 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 2
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 14657031
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDC23 Gene

Pathways for CDC23 Gene

SuperPathways for CDC23 Gene

genes like me logo Genes that share pathways with CDC23: view

UniProtKB/Swiss-Prot Q9UJX2-CDC23_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CDC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9790767
GO:0007067 mitotic nuclear division IDA 14657031
GO:0007080 mitotic metaphase plate congression IDA 14657031
GO:0007091 metaphase/anaphase transition of mitotic cell cycle TAS 9790767
genes like me logo Genes that share ontologies with CDC23: view

Transcripts for CDC23 Gene

Unigene Clusters for CDC23 Gene

Cell division cycle 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9:
SP10:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CDC23 Gene

GeneLoc Exon Structure for
CDC23
ECgene alternative splicing isoforms for
CDC23

Expression for CDC23 Gene

mRNA expression in normal human tissues for CDC23 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC23 Gene

SOURCE GeneReport for Unigene cluster for CDC23 Gene Hs.73625

genes like me logo Genes that share expressions with CDC23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDC23 Gene

Orthologs for CDC23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC23 35
  • 99.66 (n)
  • 99.83 (a)
CDC23 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDC23 35
  • 92.91 (n)
  • 97.32 (a)
CDC23 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC23 35
  • 92.41 (n)
  • 98.66 (a)
CDC23 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc23 35
  • 88.55 (n)
  • 95.48 (a)
Cdc23 16
Cdc23 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDC23 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC23 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc23 35
  • 88.67 (n)
  • 95.64 (a)
chicken
(Gallus gallus)
Aves CDC23 35
  • 80.29 (n)
  • 92.35 (a)
CDC23 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC23 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc23 35
  • 77.62 (n)
  • 90.56 (a)
Str.8410 35
zebrafish
(Danio rerio)
Actinopterygii cdc23 35
  • 71.33 (n)
  • 80.94 (a)
cdc23 36
  • 79 (a)
OneToOne
zgc56013 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009880 35
  • 52.89 (n)
  • 49.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc23 35
  • 54.75 (n)
  • 50.67 (a)
cdc23 36
  • 40 (a)
OneToMany
CG31687 36
  • 44 (a)
OneToMany
CG2508 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea mat-3 36
  • 29 (a)
OneToOne
mat-3 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR206W 35
  • 47.97 (n)
  • 39.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC23 35
  • 47.2 (n)
  • 38.45 (a)
CDC23 36
  • 29 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05258g 35
  • 49.92 (n)
  • 40.64 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC8 35
  • 53.55 (n)
  • 46.99 (a)
rice
(Oryza sativa)
Liliopsida Os.22624 35
Os02g0656300 35
  • 55.71 (n)
  • 50.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01174 35
  • 49.33 (n)
  • 43.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut23 35
  • 48.73 (n)
  • 42.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5916 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8976 36
  • 43 (a)
OneToOne
Species with no ortholog for CDC23:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC23 Gene

ENSEMBL:
Gene Tree for CDC23 (if available)
TreeFam:
Gene Tree for CDC23 (if available)

Paralogs for CDC23 Gene

No data available for Paralogs for CDC23 Gene

Variants for CDC23 Gene

Sequence variations from dbSNP and Humsavar for CDC23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1016647 -- 138,208,708(+) TTTTT(C/T)TGTTT intron-variant
rs1056698 -- 138,198,224(-) AAATA(C/T)CGTGT synonymous-codon, reference
rs1802292 -- 138,188,797(-) CAGGA(A/T)CAGAC utr-variant-3-prime
rs2057831 -- 138,199,444(+) aaaaa(A/G)agaAA intron-variant
rs2107682 -- 138,207,446(+) TGACT(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC23 Gene

Variant ID Type Subtype PubMed ID
nsv882937 CNV Loss 21882294
esv2670577 CNV Deletion 23128226

Relevant External Links for CDC23 Gene

HapMap Linkage Disequilibrium report
CDC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC23 Gene

Disorders for CDC23 Gene

No disorders were found for CDC23 Gene.

No data available for UniProtKB/Swiss-Prot for CDC23 Gene

Publications for CDC23 Gene

  1. Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (PMID: 9790767) Zhao N. … Le Beau M.M. (Genomics 1998) 2 3 4 23
  2. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 3 23
  3. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C. … Peters J.-M. (EMBO J. 2003) 3 4
  4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4
  5. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4

Products for CDC23 Gene

Sources for CDC23 Gene

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