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Aliases for CDC20B Gene

Aliases for CDC20B Gene

  • Cell Division Cycle 20B 2 3 5
  • CDC20 Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle 20 Homolog B (S. Cerevisiae) 2
  • Cell Division Cycle Protein 20 Homolog B 3
  • CDC20 Cell Division Cycle 20 Homolog B 3
  • Cell Division Cycle 20 Homolog B 3
  • CDC20-Like Protein 3
  • G6VTS76519 3

External Ids for CDC20B Gene

Previous GeneCards Identifiers for CDC20B Gene

  • GC05M054445
  • GC05M051381

Summaries for CDC20B Gene

GeneCards Summary for CDC20B Gene

CDC20B (Cell Division Cycle 20B) is a Protein Coding gene. Among its related pathways are DNA Damage Response. An important paralog of this gene is CDC20.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC20B Gene

Genomics for CDC20B Gene

Regulatory Elements for CDC20B Gene

Enhancers for CDC20B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G054900 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +271.0 270999 2.7 PKNOX1 MAX RELA POLR2A EED FOS ETV6 CREM CBFB NR2F1 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 SNX18
GH05G055173 0.9 ENCODE 12.8 -0.5 -534 0.6 PKNOX1 ATF1 RB1 CREB3L1 SIN3A BMI1 ZNF2 GLIS2 RELB ZNF391 ENSG00000240535 CDC20B LOC105378973 CCNO GC05P055180 PIR47804
GH05G055101 0.9 Ensembl ENCODE 8.3 +71.0 71034 1.8 HDGF PKNOX1 ZNF366 POLR2A MTA1 IKZF1 ZNF512 PHB2 NBN ZBTB33 CDC20B GZMA GZMAP1
GH05G054906 0.7 ENCODE 10.6 +267.0 267040 0.1 CTCF ZNF654 TEAD1 TEAD4 INSM2 MAFG REST RAD21 YY1 TEAD3 GPX8 ENSG00000249016 GZMK MIR449B MIR449A CDC20B MIR449C ENSG00000240535 LOC100130990 SNX18
GH05G055159 0.9 ENCODE 5.4 +12.4 12387 2.4 SIN3A FEZF1 BRCA1 ZNF2 ZNF263 SP3 ZHX2 MEF2D MAFF GLIS1 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B GPX8 MIR449A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC20B on UCSC Golden Path with GeneCards custom track

Promoters for CDC20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180730 -123 601 HDAC1 PKNOX1 ATF1 RB1 SIN3A BMI1 GLIS2 ZNF391 SP3 SMARCC1

Genomic Location for CDC20B Gene

Chromosome:
5
Start:
55,112,971 bp from pter
End:
55,173,177 bp from pter
Size:
60,207 bases
Orientation:
Minus strand

Genomic View for CDC20B Gene

Genes around CDC20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC20B Gene

Proteins for CDC20B Gene

  • Protein details for CDC20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y33-CD20B_HUMAN
    Recommended name:
    Cell division cycle protein 20 homolog B
    Protein Accession:
    Q86Y33
    Secondary Accessions:
    • B7WNV8
    • B9EGL8
    • C9J6X8
    • C9JHE9
    • C9JKL5
    • Q86Y31
    • Q86Y32
    • Q8IUZ8
    • Q8N1S1
    • Q8NG56

    Protein attributes for CDC20B Gene

    Size:
    519 amino acids
    Molecular mass:
    57335 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB97393.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC20B Gene

Post-translational modifications for CDC20B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDC20B Gene

No data available for DME Specific Peptides for CDC20B Gene

Domains & Families for CDC20B Gene

Gene Families for CDC20B Gene

Suggested Antigen Peptide Sequences for CDC20B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y33

UniProtKB/Swiss-Prot:

CD20B_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
genes like me logo Genes that share domains with CDC20B: view

Function for CDC20B Gene

Gene Ontology (GO) - Molecular Function for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0010997 anaphase-promoting complex binding IEA --
GO:0097027 ubiquitin-protein transferase activator activity IEA --
genes like me logo Genes that share ontologies with CDC20B: view
genes like me logo Genes that share phenotypes with CDC20B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC20B Gene

Localization for CDC20B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC20B gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDC20B Gene

Pathways & Interactions for CDC20B Gene

SuperPathways for CDC20B Gene

SuperPathway Contained pathways
1 DNA Damage Response
genes like me logo Genes that share pathways with CDC20B: view

Pathways by source for CDC20B Gene

1 BioSystems pathway for CDC20B Gene

Gene Ontology (GO) - Biological Process for CDC20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904668 positive regulation of ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with CDC20B: view

No data available for SIGNOR curated interactions for CDC20B Gene

Transcripts for CDC20B Gene

Unigene Clusters for CDC20B Gene

Cell division cycle 20B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC20B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CDC20B Gene

GeneLoc Exon Structure for
CDC20B
ECgene alternative splicing isoforms for
CDC20B

Expression for CDC20B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC20B Gene

mRNA differential expression in normal tissues according to GTEx for CDC20B Gene

This gene is overexpressed in Testis (x30.7), Lung (x9.9), and Kidney - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CDC20B Gene

This gene is overexpressed in Bone marrow stromal cell (28.9), Fetal ovary (26.1), and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDC20B Gene



NURSA nuclear receptor signaling pathways regulating expression of CDC20B Gene:

CDC20B

SOURCE GeneReport for Unigene cluster for CDC20B Gene:

Hs.669184

Evidence on tissue expression from TISSUES for CDC20B Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with CDC20B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC20B Gene

Orthologs for CDC20B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC20B 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia CDC20B 34 35
  • 85.56 (n)
cow
(Bos Taurus)
Mammalia CDC20B 34 35
  • 84.67 (n)
mouse
(Mus musculus)
Mammalia Cdc20b 34 16 35
  • 78.98 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC20B 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CDC20B 34 35
  • 60.64 (n)
lizard
(Anolis carolinensis)
Reptilia CDC20B 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc20b 34
  • 57.14 (n)
Str.16369 34
zebrafish
(Danio rerio)
Actinopterygii si:ch73-182a11.1 35
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fzy 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fzy-1 35
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10505 35
  • 26 (a)
OneToMany
Species where no ortholog for CDC20B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC20B Gene

ENSEMBL:
Gene Tree for CDC20B (if available)
TreeFam:
Gene Tree for CDC20B (if available)

Paralogs for CDC20B Gene

Paralogs for CDC20B Gene

(2) SIMAP similar genes for CDC20B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC20B: view

Variants for CDC20B Gene

Sequence variations from dbSNP and Humsavar for CDC20B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000008120 -- 55,169,268(+) ATTTA(A/T)CCCAT intron-variant
rs1000013840 -- 55,124,488(+) ATTAC(G/T)CAAAG intron-variant
rs1000032277 -- 55,154,524(+) AAGAA(A/G)AAAGA intron-variant
rs1000064221 -- 55,161,974(+) AAATG(A/G)GCTAT intron-variant
rs1000079331 -- 55,117,900(+) ACCTA(A/C)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC20B Gene

Variant ID Type Subtype PubMed ID
nsv477405 CNV novel sequence insertion 20440878
nsv4833 CNV deletion 18451855
nsv823075 CNV loss 20364138
nsv823077 CNV loss 20364138
nsv830301 CNV gain 17160897
nsv830302 CNV gain 17160897

Variation tolerance for CDC20B Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC20B Gene

Disorders for CDC20B Gene

Relevant External Links for CDC20B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC20B

No disorders were found for CDC20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC20B Gene

Publications for CDC20B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for CDC20B Gene

Sources for CDC20B Gene

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