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CDC20B Gene

protein-coding   GIFtS: 43
GCID: GC05M054445

Cell Division Cycle 20B

(Previous names: CDC20 cell division cycle 20 homolog B (S. cerevisiae),...)
  Search for CDC20B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 20B1 2     CDC20-Like Protein2
CDC20 Cell Division Cycle 20 Homolog B (S. Cerevisiae)1     Cell Division Cycle 20 Homolog B2
Cell Division Cycle 20 Homolog B (S. Cerevisiae)1     Cell Division Cycle Protein 20 Homolog B2
CDC20 Cell Division Cycle 20 Homolog B2     

External Ids:    HGNC: 242221   Entrez Gene: 1669792   Ensembl: ENSG000001642877   UniProtKB: Q86Y333   

Export aliases for CDC20B gene to outside databases

Previous GC identifer: GC05M051381


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDC20B Gene:
CDC20B (cell division cycle 20B) is a protein-coding gene. An important paralog of this gene is CDC20.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDC20B gene promoter:
         TBP   Olf-1   MIF-1   POU3F2   HNF-3beta   Evi-1   AREB6   SRY   LyF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC20B promoter sequence
   Search Chromatin IP Primers for CDC20B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC20B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

CDC20B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC20B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M054445:  view genomic region     (about GC identifiers)

Start:
54,408,799 bp from pter      End:
54,469,005 bp from pter
Size:
60,207 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD20B_HUMAN, Q86Y33 (See protein sequence)
Recommended Name: Cell division cycle protein 20 homolog B  
Size: 519 amino acids; 57335 Da
Sequence caution: Sequence=BAB97393.1; Type=Erroneous initiation;
Secondary accessions: B7WNV8 B9EGL8 C9J6X8 C9JHE9 C9JKL5 Q86Y31 Q86Y32 Q8IUZ8 Q8N1S1 Q8NG56
Alternative splicing: 5 isoforms:  Q86Y33-1   Q86Y33-2   Q86Y33-3   Q86Y33-4   Q86Y33-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC20B: NX_Q86Y33

Explore proteomics data for CDC20B at MOPED


See CDC20B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001139206.2  NP_001163873.1  NP_689836.2  

ENSEMBL proteins: 
 ENSP00000296733   ENSP00000370781   ENSP00000315720   ENSP00000426776   ENSP00000423919  
 ENSP00000335664   ENSP00000330566  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
WDR: WD repeat domain containing

4 InterPro protein domains:
 IPR019775 WD40_repeat_CS
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_dom
 IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q86Y33

ProtoNet protein and cluster: Q86Y33

1 Blocks protein domain: IPB000002 Cdc20/Fizzy

UniProtKB/Swiss-Prot: CD20B_HUMAN, Q86Y33
Similarity: Belongs to the WD repeat CDC20/Fizzy family
Similarity: Contains 7 WD repeats


CDC20B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
CDC20B for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CDC20B:
 Increased HPV18 LCR reporter a 

Animal Models:
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5 qRT-PCR Assays for microRNAs that regulate CDC20B:
hsa-miR-4314 hsa-miR-4254 hsa-miR-610 hsa-miR-330-5p hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidCDC20B 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CDC20B
Predesigned siRNA for gene silencing in human, mouse, rat CDC20B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytoskeleton1
cytosol1
extracellular1
lysosome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CDC20B About    
See pathways by source

SuperPathContained pathways About
1miRNA Regulation of DNA Damage Response
miRNA Regulation of DNA Damage Response


1 BioSystems Pathway for CDC20B
    miRNA Regulation of DNA Damage Response



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDC20B
Interactions:

    Search GeneGlobe Interaction Network for CDC20B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CDC20B (ENSP000002967334) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
InteractantInteraction Details
GeneCardExternal ID(s)
ATRENSP000003437414STRING: ENSP00000343741
CCT7ENSP000002580914STRING: ENSP00000258091
ESPL1ENSP000002579344STRING: ENSP00000257934
RIOK2ENSP000002831094STRING: ENSP00000283109
TSR1ENSP000003013644STRING: ENSP00000301364
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CDC20B (CD20B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CDC20B gene (3 alternative transcripts): 
NM_001145734.2  NM_001170402.1  NM_152623.2  

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296733 ENST00000381375 ENST00000322374 ENST00000513180 ENST00000507931(uc003jpp.3)
ENST00000334206(uc003jpo.2 uc003jpn.2 uc010ivu.2 uc010ivv.2)
ENST00000331730
miRNA
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5 qRT-PCR Assays for microRNAs that regulate CDC20B:
hsa-miR-4314 hsa-miR-4254 hsa-miR-610 hsa-miR-330-5p hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidCDC20B 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20B
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDC20B
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  QuantiFast Probe-based Assays in human, mouse, rat CDC20B

18 AceView cDNA sequences:

CB242380 AI470220 BI768657 AI696537 AB077044 AB081750 AI471861 BC037547 
AK095246 AB077043 AI925185 AW169495 BV176415 NM_152623 AW051352 AB086378 
BM974396 BP356598 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC20B (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1:                                            -                       -                       -                       -               
SP2:                                            -                       -                       -                                       
SP3:                                            -                       -                       -           -                           
SP4:                                            -                       -                                                               
SP5:                          -                 -                                                                                       


ECgene alternative splicing isoforms for CDC20B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDC20B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAACCTCCG
CDC20B Expression
About this image

CDC20B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CDC20B Protein Expression
    Custom PCR Arrays for CDC20B
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC20B gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cdc20b1 , 5 cell division cycle 20 homolog B (S. cerevisiae)5
cell division cycle 20B1
78.98(n)1
72.53(a)1
  13 (63.93 cM)5
2388961  NM_001281487.11  NP_001268416.11 
 1130351115 
chicken
(Gallus gallus)
Aves CDC20B1 cell division cycle 20 homolog B (S. cerevisiae) 60.64(n)
53.85(a)
  426169  XM_423833.4  XP_423833.4 
lizard
(Anolis carolinensis)
Reptilia CDC20B6
cell division cycle 20B
40(a)
1 ↔ 1
2(2661010-2695587)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.163692 Transcribed sequence with weak similarity to protein more 76.41(n)    BX697919.1 
zebrafish
(Danio rerio)
Actinopterygii si:ch73-182a11.16
si:ch73-182a11.1
25(a)
many ↔ many
2(5769028-5791691) ENSDARG00000022810
fruit fly
(Drosophila melanogaster)
Insecta fzy6
fizzy
27(a)
1 → many
2L(16310929-16313097)
worm
(Caenorhabditis elegans)
Secernentea fzy-16
Protein FZY-1 (fzy-1) mRNA, complete cds
17(a)
1 → many
II(5501633-5503906) WBGene00001511
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH16
Cell-cycle regulated activator of the anaphase-pro...
22(a)
1 → many
VII(492474-494174) YGL003C


ENSEMBL Gene Tree for CDC20B (if available)
TreeFam Gene Tree for CDC20B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CDC20B gene
CDC202  FZR12  
2 SIMAP similar genes for CDC20B using alignment to 1 protein entry:     CD20B_HUMAN:
FZR1    CDC20

CDC20B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CDC20B (see all 1004)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1423640531,2
--54407538(+) ACATGG/TTGACA 3 -- us2k10--------
rs1928511351,2
--54407613(+) TTAATA/GGTGAG 3 -- us2k10--------
rs1384133791,2
--54408346(+) GTAATA/GCCTGG 3 -- ds50010--------
rs68931881,2
C,F,A,H--54408370(+) TCAAAT/ATAAAA 3 -- ds50016Minor allele frequency- A:0.08NS EA WA 530
rs100613961,2
C,F,H--54408388(+) AGAAGA/GGTGTG 3 -- ds50017Minor allele frequency- G:0.08NS EA NA WA 536
rs3963351,2
C,F--54408506(-) ATATAT/CATTTT 3 -- ds50011Minor allele frequency- C:0.04NA 120
rs100684631,2
C,F,H--54408616(+) TTGGGG/AGCATA 3 -- ds500111Minor allele frequency- A:0.07NS EA WA 1434
rs2001889381,2
C--54408641(+) TTAGT-/AAAAAA 3 -- ds50010--------
rs1427468191,2
--54408710(+) GAACAC/TATGAA 3 -- ds50010--------
rs1473678131,2
--54408797(+) AACGAC/TTCAAA 3 -- ds50010--------

HapMap Linkage Disequilibrium report for CDC20B (54408799 - 54469005 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CDC20B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv823075CNV Loss20364138
nsv4833CNV Loss18451855
nsv823077CNV Loss20364138
nsv830302CNV Gain17160897
nsv830301CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CDC20B
DNA2.0 Custom Variant and Variant Library Synthesis for CDC20B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CDC20B gene integrated from 10 sources:
(articles sorted by number of sources associating them with CDC20B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 166979 HGNC: 24222 AceView: FLJ37927 Ensembl:ENSG00000164287 euGenes: HUgn166979
ECgene: CDC20B H-InvDB: CDC20B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CDC20B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CDC20B gene:
Search GeneIP for patents involving CDC20B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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