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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC20B Gene

protein-coding GIFtS: 45
GCID: GC05M054445

cell division cycle 20B

(Previous names: CDC20 cell division cycle 20 homolog B (S. cerevisiae),...)

Explore 1 disease affiliated with
CDC20B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 20B¹ ²		CDC20 Cell Division Cycle 20 Homolog B²
FLJ37927¹		CDC20-Like Protein²
CDC20 Cell Division Cycle 20 Homolog B (S. Cerevisiae)¹		Cell Division Cycle 20 Homolog B²
Cell Division Cycle 20 Homolog B (S. Cerevisiae)¹		Cell Division Cycle Protein 20 Homolog B²

External Ids:	HGNC: 24222¹	Entrez Gene: 166979²	Ensembl: ENSG00000164287⁷	UniProtKB: Q86Y33³

Export aliases for CDC20B gene to outside databases

Previous GC identifer: GC05M051381

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC20B gene promoter:
TBP Olf-1 MIF-1 POU3F2 HNF-3beta Evi-1 AREB6 SRY LyF-1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC20B promoter sequence

Search SABiosciences Chromatin IP Primers for CDC20B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC20B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

CDC20B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC20B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M054445: view genomic region (about GC identifiers)

Start:	54,408,799 bp from pter	End:	54,469,005 bp from pter
Size:	60,207 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD20B_HUMAN, Q86Y33 (See protein sequence)

Recommended Name: Cell division cycle protein 20 homolog B

Size: 519 amino acids; 57335 Da

Sequence caution: Sequence=BAB97393.1; Type=Erroneous initiation;

Secondary accessions: B7WNV8 B9EGL8 C9J6X8 C9JHE9 C9JKL5 Q86Y31 Q86Y32 Q8IUZ8 Q8N1S1 Q8NG56

Alternative splicing: 5 isoforms: Q86Y33-1 Q86Y33-2 Q86Y33-3 Q86Y33-4 Q86Y33-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC20B: NX_Q86Y33

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86Y33

CDC20B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001139206.2 NP_001163873.1 NP_689836.2

ENSEMBL proteins:

ENSP00000296733 ENSP00000370781 ENSP00000315720 ENSP00000426776 ENSP00000423919

ENSP00000335664 ENSP00000330566

Human Recombinant Protein Products for CDC20B:

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	Uscn ELISAs and CLIAs for CDC20B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC20B for domains About GeneDecksing

4 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q86Y33

ProtoNet protein and cluster: Q86Y33

1 Blocks protein family: IPB000002 Cdc20/Fizzy

UniProtKB/Swiss-Prot: CD20B_HUMAN, Q86Y33

Similarity: Belongs to the WD repeat CDC20/Fizzy family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for CDC20B:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDC20B

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC20B
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC20B:
		hsa-miR-4314 hsa-miR-4254 hsa-miR-610 hsa-miR-330-5p hsa-miR-326
		SwitchGear 3'UTR luciferase reporter plasmid: CDC20B 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDC20B

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for CDC20B (ENSP00000296733⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD2L1	ENSP00000296509⁴	STRING: ENSP00000296509
CDC16	ENSP00000348554⁴	STRING: ENSP00000348554
CDC23	ENSP00000378350⁴	STRING: ENSP00000378350
ANAPC10	ENSP00000310071⁴	STRING: ENSP00000310071
--	ENSP00000399255⁴	STRING: ENSP00000399255

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC20B
Search CenterWatch for drugs/clinical trials and news about CDC20B / CD20B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC20B gene (3 alternative transcripts):

NM_001145734.2 NM_001170402.1 NM_152623.2

Unigene Cluster for CDC20B:

Cell division cycle 20 homolog B (S. cerevisiae)

Hs.669184 [show with all ESTs]

Unigene Representative Sequence: NM_001170402

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296733 ENST00000381375 ENST00000322374 ENST00000513180 ENST00000507931(uc003jpp.3)

ENST00000334206(uc003jpo.2 uc003jpn.2 uc010ivu.2 uc010ivv.2)

ENST00000331730

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC20B:
		hsa-miR-4314 hsa-miR-4254 hsa-miR-610 hsa-miR-330-5p hsa-miR-326
		SwitchGear 3'UTR luciferase reporter plasmid: CDC20B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CDC20B

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Additional cDNA sequence:

AB077043.1 AB077044.1 AB081750.1 AB086378.1 AK095246.1 BC037547.1 BC136572.1

5 DOTS entries:

DT.75114397 DT.100643550 DT.75101394 DT.97856793 DT.120822634

18 AceView cDNA sequences:

AI470220 CB242380 AW051352 AI925185 AB077044 AI471861 AW169495 NM_152623

BI768657 AI696537 AK095246 BV176415 AB077043 AB081750 AB086378 BC037547

BM974396 BP356598

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDC20B (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b
SP1:															-								-								-								-
SP2:															-								-								-
SP3:															-								-								-				-
SP4:															-								-
SP5:									-						-

ECgene alternative splicing isoforms for CDC20B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC20B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAACCTCCG

About this image

CDC20B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDC20B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC20B

SOURCE GeneReport for Unigene cluster: Hs.669184

SABiosciences Custom PCR Arrays for CDC20B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC20B Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20B gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdc20b^{1 , 5}	cell division cycle 20 homolog B (S. cerevisiae)⁵ cell division cycle 20B¹	78.98(n)¹ 72.53(a)¹		13 (63.93 cM)⁵ 238896¹ XM_138861.7¹ XP_138861.7¹ 113054668⁵
chicken (Gallus gallus)	Aves	CDC20B¹	cell division cycle 20 homolog B (S. cerevisiae)	61.11(n) 54.33(a)		426169 XM_423833.3 XP_423833.3
lizard (Anolis carolinensis)	Reptilia	CDC20B⁶	--	48(a)	1 ↔ 1	2(2661317-2692504)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.16369²	Transcribed sequence with weak similarity to protein more	76.41(n)		BX697919.1
fruit fly (Drosophila melanogaster)	Insecta	fzy⁶	fizzy	25(a)	possible ortholog	2L(16310929-16313097)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G27570⁶ CDC20.2⁶ (see all 6)	cell division cycle 20, cofactor of APC complex (see all 6)	25(a) 24(a) (see all 6)	possible ortholog possible ortholog (see all 6)	5(9734896-9736131) 4(16041067-16043457)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	WD repeat-containing protein, putative, expressed (see all 3)	24(a) 24(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(28796924-28800123) 4(30082705-30085581)

ENSEMBL Gene Tree for CDC20B (if available)
TreeFam Gene Tree for CDC20B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDC20B gene

CDC20²

2 SIMAP similar genes for CDC20B using alignment to 1 protein entry: CD20B_HUMAN:

FZR1 CDC20

CDC20B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35963631^1,2	C	--	51413037(+)	`TATGG-/AAAAAA`	1	--	int¹		1		CSA	2
rs138413379^1,2		--	54408346(+)	`GTAATA/GCCTGG`	3	--	ds500¹		0	--	--	--	--
rs6893188^1,2	C,F,A,H	--	54408370(+)	`TCAAAT/ATAAAA`	3	--	ds500¹		6		NS EA WA	530
rs10061396^1,2	C,F,H	--	54408388(+)	`AGAAGA/GGTGTG`	3	--	ds500¹		7		NS EA NA WA	536
rs396335^1,2	C,F	--	54408506(-)	`ATATAT/CATTTT`	3	--	ds500¹		1		NA	120
rs10068463^1,2	C,F,H	--	54408616(+)	`TTGGGG/AGCATA`	3	--	ds500¹		11		NS EA WA	1434
rs200188938^1,2		--	54408641(+)	`TTAGT-/AAAAAA`	3	--	ds500¹		0	--	--	--	--
rs142746819^1,2		--	54408710(+)	`GAACAC/TATGAA`	3	--	ds500¹		0	--	--	--	--
rs147367813^1,2		--	54408797(+)	`AACGAC/TTCAAA`	3	--	ds500¹		0	--	--	--	--
rs139561220^1,2		--	54408822(+)	`TTTTTA/TAAACA`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDC20B (54408799 - 54469005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CDC20B
3 CNVs: 80923 36418 93056
1 Indel: 93057

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC20B

DNA2.0 Custom Variant and Variant Library Synthesis for CDC20B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC20B for disorders About GeneDecksing

1 disease for CDC20B: About MalaCards

malaria

Export disorders for CDC20B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC20B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDC20B)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 166979	HGNC: 24222	AceView: FLJ37927	Ensembl:ENSG00000164287	euGenes: HUgn166979
ECgene: CDC20B	H-InvDB: CDC20B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC20B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDC20B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDC20B gene:
Search GeneIP for patents involving CDC20B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDC20B gene at Home site.

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CDC20B Gene

cell division cycle 20B

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CDC20B Gene

cell division cycle 20B

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