Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDC20 Gene

protein-coding   GIFtS: 66
GCID: GC01P043824

Cell Division Cycle 20

(Previous names: CDC20 (cell division cycle 20, S. cerevisiae, homolog),...)
  Search for CDC20
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cell Division Cycle 201 2     CDC20A2
p55CDC2 3     bA276H19.32
CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog)1     CDC20 Cell Division Cycle 20 Homolog2
CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae)1     Cell Division Cycle 20 Homolog2
Cell Division Cycle 20 Homolog (S. Cerevisiae)1     Cell Division Cycle Protein 20 Homolog2

External Ids:    HGNC: 17231   Entrez Gene: 9912   Ensembl: ENSG000001173997   OMIM: 6036185   UniProtKB: Q128343   

Export aliases for CDC20 gene to outside databases

Previous GC identifers: GC01P043767 GC01P042825 GC01P043254 GC01P043237 GC01P043208 GC01P043493 GC01P043597 GC01P041944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDC20 Gene:
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the
cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and
chromosome separation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC20 Gene:
CDC20 (cell division cycle 20) is a protein-coding gene. GO annotations related to this gene include protein C-terminus binding and enzyme binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may
confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C
ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The
CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the
presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic
differentiation

Gene Wiki entry for CDC20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC20 gene promoter:
         MZF-1   p53   AML1a   HTF   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC20 promoter sequence
   Search Chromatin IP Primers for CDC20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

CDC20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043824:  view genomic region     (about GC identifiers)

Start:
43,824,626 bp from pter      End:
43,828,874 bp from pter
Size:
4,249 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834 (See protein sequence)
Recommended Name: Cell division cycle protein 20 homolog  
Size: 499 amino acids; 54723 Da
Subunit: Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2 (By
similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL.
May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2
Developmental stage: Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly
degraded at M/G1 transition
3 PDB 3D structures from and Proteopedia for CDC20:
4GGA (3D)        4GGC (3D)        4GGD (3D)    
Secondary accessions: B2R6Z6 D3DPJ1 Q5JUY4 Q9BW56 Q9UQI9

Explore the universe of human proteins at neXtProt for CDC20: NX_Q12834

Explore proteomics data for CDC20 at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41;
    Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK21
  • Dephosphorylated by CTDP11
  • Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading
    to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C.
    Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability
    to bind the APC/C complex1
  • Ubiquitination2 at Lys97, Lys114, Lys129, Lys136, Lys149, Lys155, Lys259, Lys485, Lys490
  • Modification sites at PhosphoSitePlus

  • See CDC20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001246.2  
    ENSEMBL proteins: 
     ENSP00000308450   ENSP00000361540  
    Reactome Protein details: Q12834

    CDC20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDC20
    OriGene Protein Over-expression Lysate for CDC20
    OriGene MassSpec for CDC20
    OriGene Custom Protein Services for CDC20
    GenScript Custom Purified and Recombinant Proteins Services for CDC20
    Novus Biologicals CDC20 Proteins
    Novus Biologicals CDC20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC20

     
    Search eBioscience for Proteins for CDC20 

    CDC20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC20
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDC20 
    OriGene Antibodies for CDC20
    OriGene Custom Antibody Services for CDC20
    Novus Biologicals CDC20 Antibodies
    Abcam antibodies for CDC20
    Cloud-Clone Corp. Antibodies for CDC20
    ThermoFisher Antibody for CDC20
    LSBio Antibodies in human, mouse, rat for CDC20

    CDC20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDC20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDC20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC20
    Cloud-Clone Corp. CLIAs for CDC20
    Search eBioscience for ELISAs for CDC20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q12834

    ProtoNet protein and cluster: Q12834

    2 Blocks protein domains:
    IPB000002 Cdc20/Fizzy
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
    Similarity: Belongs to the WD repeat CDC20/Fizzy family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with CDC20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC20_HUMAN, Q12834
    Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may
    confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C
    ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The
    CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the
    presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic
    differentiation

         Genatlas biochemistry entry for CDC20:
    cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog
    to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the
    cyclosome/anaphase-promoting complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11030144
    GO:0008022protein C-terminus binding IPI10700282
    GO:0019899enzyme binding IPI17443180
         
    Find genes that share ontologies with CDC20           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDC20:
     Cell cycle / mitosis defect  Increased G2M DNA content  Increased Salmonella enterica   Increased cell death HMECs cel 
     Increased number of mitotic ce 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdc20):
     cellular  digestive/alimentary  embryogenesis  growth/size/body  integument 
     mortality/aging  no phenotypic analysis  other  reproductive system  tumorigenesis 

    Find genes that share phenotypes with CDC20           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDC20: Cdc20tm1.2Mama Cdc20tm1Jvd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC20

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC20:
    hsa-mir-30a-5p (MIRT028518), hsa-mir-34a-5p (MIRT025414), hsa-mir-215-5p (MIRT024643), hsa-mir-18a-5p (MIRT050708), hsa-mir-192-5p (MIRT026319), hsa-mir-92a-3p (MIRT049389), hsa-mir-93-3p (MIRT038870), hsa-mir-16-5p (MIRT031615), hsa-mir-188-5p (MIRT044902), hsa-mir-193b-3p (MIRT016385), hsa-mir-941 (MIRT036567), hsa-mir-23b-3p (MIRT046369)

    Block miRNA regulation of human, mouse, rat CDC20 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDC20
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC20
    Predesigned siRNA for gene silencing in human, mouse, rat CDC20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC20

    Clone
    Products:
         
    OriGene clones in human, mouse for CDC20 (see all 8)
    OriGene ORF clones in mouse, rat for CDC20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDC20 (NM_001255)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20
    Addgene plasmids for CDC20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDC20
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-11543) for CDC20 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CDC20_HUMAN, Q12834: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle pole
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680colocalizes with anaphase-promoting complex IDA11459825
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CDC20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CDC20 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4PLK1 signaling events
    PLK1 signaling events
    Phosphorylation of Emi10.00
    5CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G10.93
    Regulation of mitotic cell cycle0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of APC/C activators between G1/S and early anaphase0.94
    SCF-beta-TrCP mediated degradation of Emi10.91
    APC/C-Cdc20 mediated degradation of Securin0.93
    Cell Cycle Checkpoints0.58


    Find genes that share SuperPaths with CDC20           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDC20
        Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for CDC20
        Cell Cycle / Checkpoint Control
    Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for CDC20
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for CDC20
        Cell cycle
    PLK1 signaling events

    Selected Reactome Pathways for CDC20 (see all 14)
        Resolution of Sister Chromatid Cohesion
    SCF-beta-TrCP mediated degradation of Emi1
    Mitotic Prometaphase
    APC/C:Cdc20 mediated degradation of mitotic proteins
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase


    5 Kegg Pathways  (Kegg details for CDC20):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    HTLV-I infection
    Viral carcinogenesis

    UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC20: 

              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC20 (Q128341, 2, 3 ENSP000003084504) via UniProtKB, MINT, STRING, and/or I2D (see all 828)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L1Q132571, 2, 3, ENSP000002965094EBI-367462,EBI-78203 MINT-8183760 MINT-8289337 MINT-8284921 MINT-2211306 MINT-8183848 MINT-8413025 MINT-8284907 MINT-8289292 I2D: score=6 STRING: ENSP00000296509
    CDC27P302601, 2, 3EBI-367462,EBI-994813 MINT-8289337 MINT-7947479 I2D: score=5 
    CDC16Q130422, 3, ENSP000003485544MINT-7947479 I2D: score=4 STRING: ENSP00000348554
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7947479 I2D: score=3 STRING: ENSP00000339109
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=3 STRING: ENSP00000314004
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007049cell cycle TAS9682218
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with CDC20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC20

    3 Novoseek inferred chemical compound relationships for CDC20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 50 1 11030144 (1)
    serine 9.87 1 20034488 (1)
    threonine 9.67 1 20034488 (1)



    Find genes that share compounds with CDC20           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDC20 gene: 
    NM_001255.2  

    Unigene Cluster for CDC20:

    Cell division cycle 20
    Hs.524947  [show with all ESTs]
    Unigene Representative Sequence: BG256659
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310955(uc001cix.3) ENST00000372462(uc001ciy.3) ENST00000478882
    ENST00000482046
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDC20 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDC20
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDC20
    Predesigned siRNA for gene silencing in human, mouse, rat CDC20
    Clone
    Products:
         
    OriGene clones in human, mouse for CDC20 (see all 8)
    OriGene ORF clones in mouse, rat for CDC20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDC20 (NM_001255)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20
    Addgene plasmids for CDC20 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDC20
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC20
      QuantiTect SYBR Green Assays in human, mouse, rat CDC20
      QuantiFast Probe-based Assays in human, mouse, rat CDC20
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-11543) for CDC20 

    Additional mRNA sequence: 

    AF099644.1 AK225504.1 AK302539.1 AK303844.1 AK312780.1 BC000624.2 BC001088.2 BC006272.2 
    BC009425.1 BC009426.1 BC010044.2 BC012803.2 BC012827.2 BC013303.2 BC015998.1 BC024257.1 
    BC031294.1 BC110321.1 BT007388.1 U05340.1 

    20 DOTS entries:

    DT.40260876  DT.92459081  DT.95118114  DT.100886629  DT.121444968  DT.100886607  DT.75124643  DT.121444946 
    DT.92459114  DT.95118133  DT.100829532  DT.92409509  DT.95246487  DT.100886608  DT.121444971  DT.40117267 
    DT.95118100  DT.95118107  DT.95118109  DT.86851862 

    Selected AceView cDNA sequences (see all 540):

    BQ435463 BM802806 BM919353 AA814422 BQ223976 CR615732 AI923533 AI990696 
    BE672104 AA316746 BI117437 BC006272 BI042962 BI042991 CR593228 BQ225411 
    BU167726 BI871005 BM928780 BC009426 BC001088 BE884025 BM556372 BI093216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDC20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCCTTCA
    CDC20 Expression
    About this image


    CDC20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
             Oviduct
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CDC20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524947
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC20: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDC20
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC20
    QuantiTect SYBR Green Assays in human, mouse, rat CDC20
    QuantiFast Probe-based Assays in human, mouse, rat CDC20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC20 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc201 , 5 cell division cycle 20 homolog (S. cerevisiae)5
    cell division cycle 201
    88.31(n)1
    94.79(a)1
      4 (54.61 cM)5
    1079951  NM_023223.21  NP_075712.21 
     1184329015 
    chicken
    (Gallus gallus)
    Aves CDC201 cell division cycle 20 homolog (S. cerevisiae) 77(n)
    82.09(a)
      424563  NM_001006536.1  NP_001006536.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC206
    cell division cycle 20
    77(a)
    1 ↔ 1
    4(107264925-107280582)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF034578.12   -- 75.7(n)    AF034578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.263372 Danio rerio cDNA clone MGC63536 IMAGE3815834, complete more 75.12(n)    BC054907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fzy1 , 3 cyclin catabolism3
    fizzy1
    49(a)3
    56.55(n)1
    54.79(a)1
      349681  NM_058153.41  NP_477501.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fzy-16
    Protein FZY-1 (fzy-1) mRNA, complete cds
    23(a)
    1 → many
    II(5501633-5503906) WBGene00001511
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC20(YGL116W)4
    CDC201
    Cell-cycle regulated activator of anaphase-promoting more4
    CDC201
    47.37(n)1
    38.92(a)1
      7(289809-291641)4
    8527621, 4  NP_011399.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os.265752 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.94(n)    AK102954.1 


    ENSEMBL Gene Tree for CDC20 (if available)
    TreeFam Gene Tree for CDC20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDC20 gene
    FZR12  CDC20B2  
    2 SIMAP similar genes for CDC20 using alignment to 1 protein entry:     CDC20_HUMAN:
    FZR1    CDC20B

    Find genes that share paralogs with CDC20           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CDC20
    PGOHUM00000236675


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDC20 (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17499601,2
    C,F,A,H--43822664(+) AACCAC/TGACAA 1 -- us2k16Minor allele frequency- T:0.41WA NA EA 368
    rs17499611,2
    C,F,A,H--43822665(+) ACCATC/GACAAC 1 -- us2k17Minor allele frequency- G:0.41NA WA EA 370
    rs2015397441,2
    --43822769(+) CATAT-/CCCCCC 1 -- us2k10--------
    rs120759881,2
    C,F--43822885(+) CCAACT/ATGACA 1 -- us2k17Minor allele frequency- A:0.13NS WA 296
    rs1463343701,2
    --43822984(+) GAGAAG/TGCAAA 1 -- us2k10--------
    rs1133835621,2
    F--43823029(+) GCATCG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1810964711,2
    --43823088(+) CAGTAC/TAGCGT 1 -- us2k10--------
    rs1860233321,2
    --43823346(+) TCGGCA/TCACTG 1 -- us2k10--------
    rs1383170541,2
    C--43823518(+) TCTGCA/CCGCCT 1 -- us2k10--------
    rs1911717681,2
    --43823670(+) AATTCA/CCTCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC20 (43824626 - 43828874 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDC20: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC20
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603618    OMIM disorders: --


    Find genes that share disorders with CDC20           About GenesLikeMe

    6 Novoseek inferred disease relationships for CDC20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 16.7 9 17873905 (3), 17456764 (2), 16777988 (1), 18059335 (1) (see all 5)
    cancer lung 0 1 10439037 (1)
    primary tumor 0 1 16428479 (1)
    breast cancer 0 3 16428479 (1)
    tumors 0 12 16777988 (3), 17598981 (2), 12631597 (1), 17873905 (1) (see all 6)
    prostate cancer 0 6 14710249 (4)

    Genetic Association Database (GAD): CDC20
    Human Genome Epidemiology (HuGE) Navigator: CDC20 (2 documents)

    Export disorders for CDC20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDC20 gene, integrated from 10 sources (see all 254):
    (articles sorted by number of sources associating them with CDC20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. (PubMed id 7513050)1, 2, 3 Weinstein J.... Baum L.G. (Mol. Cell. Biol. 1994)
    2. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512)1, 2, 9 Tang Z.... Yu H. (Mol. Cell 2004)
    3. MAD2B is an inhibitor of the anaphase-promoting complex. (PubMed id 11459826)1, 2, 9 Chen J. and Fang G. (Genes Dev. 2001)
    4. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2, 9 Kraft C....Peters J.-M. (EMBO J. 2003)
    5. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (PubMed id 9637688)1, 2, 9 Fang G.... Kirschner M.W. (Genes Dev. 1998)
    6. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)1, 2, 9 Stegmeier F.... Elledge S.J. (Nature 2007)
    7. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (Nat. Commun. 2012)
    8. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PubMed id 21926987)1, 2 Mansfeld J.... Pines J. (Nat. Cell Biol. 2011)
    9. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    10. CDK5RAP2 is required for spindle checkpoint function. (PubMed id 19282672)1, 2 Zhang X.... Xu X. (Cell Cycle 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 991 HGNC: 1723 AceView: CDC20 Ensembl:ENSG00000117399 euGenes: HUgn991
    ECgene: CDC20 Kegg: 991 H-InvDB: CDC20

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDC20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC20 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc20/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDC20 gene:
    Search GeneIP for patents involving CDC20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CDC20
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDC20   OriGene RNAi products in human, mouse, rat for CDC20  
     OriGene qPCR primer pairs and template standards for CDC20   OriGene Protein Over-expression Lysate for CDC20  
     OriGene MassSpec something-or-other for CDC20   OriGene clones in human, mouse for CDC20  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDC20   OriGene Purified Protein for CDC20  
     OriGene ORF clones in mouse, rat for CDC20   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDC20   OriGene Custom Protein Services for CDC20  

     
     
     Block miRNA regulation of human, mouse, rat CDC20 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDC20
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC20 Predesigned siRNA for gene silencing in human, mouse, rat CDC20
     QuantiFast Probe-based Assays in human, mouse, rat CDC20 QuantiTect SYBR Green Assays in human, mouse, rat CDC20
     PCR Arrays including human, mouse, rat CDC20 Search Chromatin IP Primers for CDC20
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC20  GeneGlobe Interaction Network for CDC20
     Regulatory tfbs in CDC20 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDC20 GenScript cDNA clones with any tag delivered in your preferred vector for CDC20
     GenScript Custom Assay Services for CDC20 GenScript Custom overexpressing Cell Line Services for CDC20
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CDC20 

     Search Tocris compounds for CDC20
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDC20 antibodies
     CDC20 proteins
     CDC20 lysates
     Antibodies for CDC20
     See all of Abcam's Antibodies, Kits and Proteins for CDC20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CDC20
     Antibodies for CDC20
     ELISAs for CDC20
     CLIAs for CDC20



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDC20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CDC20
     SwitchGear Promoter luciferase reporter plasmids for CDC20
     ThermoFisher Antibody for CDC20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC20
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC20
     LSBio Antibodies in human, mouse, rat for CDC20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CDC20
      Search eBioscience for proteins for CDC20
      Search eBioscience for elisas for CDC20
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDC20 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4