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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDC20 Gene

protein-coding GIFtS: 63
GCID: GC01P043824

cell division cycle 20

(Previous names: CDC20 (cell division cycle 20, S. cerevisiae, homolog),...)

Explore 22 diseases affiliated with
CDC20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Division Cycle 20¹ ²		Cell Division Cycle 20 Homolog (S. Cerevisiae)¹
P55CDC¹		BA276H19.3¹
CDC20A¹ ²		CDC20 Cell Division Cycle 20 Homolog²
CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog)¹		Cell Division Cycle 20 Homolog²
CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae)¹		Cell Division Cycle Protein 20 Homolog²

External Ids:	HGNC: 1723¹	Entrez Gene: 991²	Ensembl: ENSG00000117399⁷	OMIM: 603618⁵	UniProtKB: Q12834³

Export aliases for CDC20 gene to outside databases

Previous GC identifers: GC01P043767 GC01P042825 GC01P043254 GC01P043237 GC01P043208 GC01P043493 GC01P043597 GC01P041944

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC20:

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell

cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome

separation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834

Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may

confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary

complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C

complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane

in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation

Gene Wiki entry for CDC20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC20 gene promoter:
MZF-1 p53 AML1a HTF CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDC20 promoter sequence

Search SABiosciences Chromatin IP Primers for CDC20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.1

CDC20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC20 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P043824: view genomic region (about GC identifiers)

Start:	43,824,626 bp from pter	End:	43,828,874 bp from pter
Size:	4,249 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834 (See protein sequence)

Recommended Name: Cell division cycle protein 20 homolog

Size: 499 amino acids; 54723 Da

Subunit: Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2 (By

similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May

interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole

Developmental stage: Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at

M/G1 transition

3 PDB 3D structures from and Proteopedia for CDC20:

4GGA (3D)

4GGC (3D)

4GGD (3D)

Secondary accessions: B2R6Z6 D3DPJ1 Q5JUY4 Q9BW56 Q9UQI9

Explore the universe of human proteins at neXtProt for CDC20: NX_Q12834

Post-translational modifications:

Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72;

Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2¹

Dephosphorylated by CTDP1¹

Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to

stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated

at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C

completo bind the APC/C complex¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12834

CDC20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001246.2

ENSEMBL proteins:

ENSP00000308450 ENSP00000361540

Reactome Protein details: Q12834
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CDC20 Proteins Novus Biologicals CDC20 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDC20

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	colocalizes with anaphase-promoting complex	IDA	11459825
GO:0005813	centrosome	IEA	--
GO:0005819	spindle	TAS	7513050

CDC20 for ontologies About GeneDecksing

CDC20 Antibody Products:

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	Uscn Antibodies for CDC20
	ThermoFisher Antibody for CDC20

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	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC20
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC20 for domains About GeneDecksing

4 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q12834

ProtoNet protein and cluster: Q12834

2 Blocks protein families:

IPB000002 Cdc20/Fizzy

IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834

Similarity: Belongs to the WD repeat CDC20/Fizzy family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834

Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may

confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary

complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C

complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane

in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation

Genatlas biochemistry entry for CDC20:

cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog to S

cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the

cyclosome/anaphase-promoting complex

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDC20
		Search LifeMap BioReagents cell lines for CDC20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008022	protein C-terminus binding	IPI	10700282
GO:0019899	enzyme binding	IPI	17443180

CDC20 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CDC20:

Cell cycle / mitosis defect	Increased G2M DNA content	Increased Salmonella enterica	Increased cell death HMECs cel
Increased number of mitotic ce

Animal Models:
Mouse knock-outs for CDC20: Cdc20^tm1.2Mama Cdc20^tm1Jvd
10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdc20):

cellular	digestive/alimentary	embryogenesis	growth/size	integument
mortality/aging	no phenotypic analysis	other	reproductive system	tumorigenesis

CDC20 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/14 pathways (see all 14)
SCF-mediated degradation of Emi1	0.87	APC/C:Cdc20 mediated degradation of mitotic proteins	0.69
SCF-beta-TrCP mediated degradation of Emi1	0.87	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69
APC/C:Cdc20 mediated degradation of Securin	0.74	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68
Degradation of multiubiquitinated Securin	0.74	Regulation of APC/C activators between G1/S and early anaphase	0.62

APC-Cdc20 mediated degradation of Nek2A

8/9 pathways (see all 9)
Degradation of multiubiquitinated Nek2A	1.00	Degradation of multiubiquitinated Cyclin B	0.76
APC-Cdc20 mediated degradation of Nek2A	1.00	Mitotic Spindle Checkpoint	0.75
Inactivation of APC/C via direct inhibition of the APC/C complex	0.78	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.60
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.78	Common schema of ubiquitination	0.35

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CDC20

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Spindle assembly and chromosome separation
	Meiosis
	Common schema of ubiquitination

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDC20

Mitotic Roles of Polo Like Kinases

2 Cell Signaling Technology (CST) Pathways for CDC20

	Cell Cycle / Checkpoint Control
	Neuroscience

2 GeneGo (Thomson Reuters) Pathways for CDC20

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Spindle assembly and chromosome separation

2 BioSystems Pathways for CDC20

	Cell cycle
	PLK1 signaling events

5/38 Reactome Pathways for CDC20 (see all 38)

	Mitotic Prometaphase
	SCF-beta-TrCP mediated degradation of Emi1
	APC/C:Cdc20 mediated degradation of mitotic proteins
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A

3 Kegg Pathways (Kegg details for CDC20):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834

Pathway: Protein modification; protein ubiquitination

CDC20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/703 Interacting proteins for CDC20 (Q12834^{1, 2, 3} ENSP00000308450⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 703)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAD2L1	Q13257¹^,²^,³, ENSP00000296509⁴	EBI-367462,EBI-78203 MINT-8183760 MINT-8289337 MINT-8284921 MINT-2211306 MINT-8183848 MINT-8413025 MINT-8284907 MINT-8289292 I2D: score=6 STRING: ENSP00000296509
CDC27	P30260¹^,²^,³	EBI-367462,EBI-994813 MINT-8289337 MINT-7947479 I2D: score=5
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7947479 I2D: score=4 STRING: ENSP00000348554
ANAPC1	Q9H1A4²^,³, ENSP00000339109⁴	MINT-7947479 I2D: score=3 STRING: ENSP00000339109
ANAPC2	Q9UJX6²^,³, ENSP00000314004⁴	MINT-7947479 I2D: score=3 STRING: ENSP00000314004

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007049	cell cycle	TAS	9682218

CDC20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDC20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC20
3 Novoseek chemical compound relationships for CDC20 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nocodazole	50	1	11030144 (1)
serine	9.87	1	20034488 (1)
threonine	9.67	1	20034488 (1)

Search CenterWatch for drugs/clinical trials and news about CDC20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDC20 gene:

NM_001255.2

Unigene Cluster for CDC20:

Cell division cycle 20 homolog (S. cerevisiae)

Hs.524947 [show with all ESTs]

Unigene Representative Sequence: BG256659

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310955(uc001cix.3) ENST00000372462(uc001ciy.3) ENST00000478882

ENST00000482046

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC20

Additional cDNA sequence:

AF099644.1 AK225504.1 AK302539.1 AK303844.1 AK312780.1 BC000624.2 BC001088.2 BC006272.2

BC009425.1 BC009426.1 BC010044.2 BC012803.2 BC012827.2 BC013303.2 BC015998.1 BC024257.1

BC031294.1 BC110321.1 BT007388.1 U05340.1

20 DOTS entries:

DT.40260876 DT.92459081 DT.95118114 DT.100886629 DT.121444968 DT.100886607 DT.75124643 DT.121444946

DT.92459114 DT.95118133 DT.100829532 DT.92409509 DT.95246487 DT.100886608 DT.121444971 DT.40117267

DT.95118100 DT.95118107 DT.95118109 DT.86851862

24/540 AceView cDNA sequences (see all 540):

BE301380 CR599336 BM772632 BQ962481 AA411428 CB125977 CB149743 AI863688

BQ223976 CR604441 BI042973 BI042975 BM457946 AA836633 BU902357 BC000624

BI042984 BM458354 BQ926648 BM764805 BQ054151 W78934 BM799130 BI117437

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDC20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCCTTCA

About this image

CDC20 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Brain

Hypothalamus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See CDC20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDC20

SOURCE GeneReport for Unigene cluster: Hs.524947

SABiosciences Expression via Pathway-Focused PCR Arrays including CDC20:

Cell Cycle in human mouse rat

Cancer PathwayFinder in human mouse rat

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC20 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC20 gene from 8/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDC20¹	cell division cycle 20 homolog (S. cerevisiae)	77(n) 82.09(a)		424563 NM_001006536.1 NP_001006536.1
lizard (Anolis carolinensis)	Reptilia	CDC20⁶	--	76(a)	1 ↔ 1	4(107267404-107277860)
African clawed frog (Xenopus laevis)	Amphibia	AF034578.1²	--	75.7(n)		AF034578.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26337²	Danio rerio cDNA clone MGC63536 IMAGE3815834, complete more	75.12(n)		BC054907.1
fruit fly (Drosophila melanogaster)	Insecta	fzy^{1 , 3}	cyclin catabolism³ fizzy¹	49(a)³ 56.55(n)¹ 54.58(a)¹		34968¹ NM_058153.3¹ NP_477501.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC20(YGL116W)⁴ CDC20¹	Cell-cycle regulated activator of anaphase-promoting more⁴ Cdc20p¹	47.37(n)¹ 38.92(a)¹		7(289809-291641)⁴ 852762^{1, 4} NP_011399.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G27570¹	cell division cycle 20, cofactor of APC complex	54.97(n) 52(a)		832817 NM_122639.1 NP_198109.1
rice (Oryza sativa)	Liliopsida	Os.26575²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	72.94(n)		AK102954.1

ENSEMBL Gene Tree for CDC20 (if available)
TreeFam Gene Tree for CDC20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDC20 gene

CDC20B²

2 SIMAP similar genes for CDC20 using alignment to 1 protein entry: CDC20_HUMAN:

FZR1 CDC20B

CDC20 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CDC20
PGOHUM00000236675

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1749960^1,2	C,F,A,H,	--	43822664(+)	`AACCAC/TGACAA`	1	--	us2k¹		6		WA NA EA	368
rs1749961^1,2	C,F,A,H,	--	43822665(+)	`ACCATC/GACAAC`	1	--	us2k¹		7		NA WA EA	370
rs201539744^1,2		--	43822769(+)	`CATAT-/CCCCCC`	1	--	us2k¹		0	--	--	--	--
rs12075988^1,2	C,F,	--	43822885(+)	`CCAACT/ATGACA`	1	--	us2k¹		7		NS WA	296
rs146334370^1,2		--	43822984(+)	`GAGAAG/TGCAAA`	1	--	us2k¹		0	--	--	--	--
rs113383562^1,2		--	43823029(+)	`GCATCG/AGAGTG`	1	--	us2k¹		1		CSA	2
rs181096471^1,2		--	43823088(+)	`CAGTAC/TAGCGT`	1	--	us2k¹		0	--	--	--	--
rs186023332^1,2		--	43823346(+)	`TCGGCA/TCACTG`	1	--	us2k¹		0	--	--	--	--
rs138317054^1,2		--	43823518(+)	`TCTGCA/CCGCCT`	1	--	us2k¹		0	--	--	--	--
rs191171768^1,2		--	43823670(+)	`AATTCA/CCTCAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDC20 (43824626 - 43828874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC20: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC20

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC20 for disorders           About GeneDecksing

OMIM gene information: 603618    OMIM disorders: --

20/22 diseases for CDC20 (see all 22):    About MalaCards

ataxia telangiectasia epithelial ovarian cancer ovarian cancer pandas

embryonal carcinoma prostate cancer breast cancer oral cancer

lung adenocarcinoma ataxia hepatocellular carcinoma gastric cancer

retinoblastoma pancreatic cancer lung cancer adenocarcinoma

prostatitis pancreatitis glioblastoma carcinoma

6 Novoseek disease relationships for CDC20 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	16.7	9	17873905 (3), 17456764 (2), 16777988 (1), 18059335 (1) (see all 5)
cancer lung	0	1	10439037 (1)
primary tumor	0	1	16428479 (1)
breast cancer	0	3	16428479 (1)
tumors	0	12	16777988 (3), 17598981 (2), 12631597 (1), 17873905 (1) (see all 6)
prostate cancer	0	6	14710249 (4)

Human Genome Epidemiology (HuGE) Navigator: CDC20 (2 documents)

Export disorders for CDC20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDC20 gene, integrated from 9 sources (see all 228):
(articles sorted by number of sources associating them with CDC20)

Utopia: connect your pdf to the dynamic
world of online information

A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. (PubMed id 7513050)^{1, 2, 3} Weinstein J.... Baum L.G. (1994)
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512)^{1, 2, 9} Tang Z....Yu H. (2004)
MAD2B is an inhibitor of the anaphase-promoting complex. (PubMed id 11459826)^{1, 2, 9} Chen J. and Fang G. (2001)
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)^{1, 2, 9} Kraft C....Peters J.-M. (2003)
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (PubMed id 9637688)^{1, 2, 9} Fang G.... Kirschner M.W. (1998)
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)^{1, 2, 9} Stegmeier F....Elledge S.J. (2007)
Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)^{1, 2} Visconti R.... Grieco D. (2012)
APC15 drives the turnover of MCC-CDC20 to make the sp indle assembly checkpoint responsive to kinetochore attachment. (PubMed id 21926987)^{1, 2} Mansfeld J....Pines J. (2011)
CDK5RAP2 is required for spindle checkpoint function. (PubMed id 19282672)^{1, 2} Zhang X....Xu X. (2009)
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. (PubMed id 19098431)^{1, 2} Ge S.... Pagano M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 991	HGNC: 1723	AceView: CDC20	Ensembl:ENSG00000117399	euGenes: HUgn991
ECgene: CDC20	Kegg: 991	H-InvDB: CDC20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDC20	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDC20	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc20/

Intellectual Property for CDC20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDC20 gene:
Search GeneIP for patents involving CDC20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cell division cycle 20

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CDC20 Gene

cell division cycle 20

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