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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC20 Gene

protein-coding   GIFtS: 65
GCID: GC01P043824

Cell Division Cycle 20

(Previous names: CDC20 (cell division cycle 20, S. cerevisiae, homolog),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 201 2     CDC20A2
p55CDC2 3     bA276H19.32
CDC20 (Cell Division Cycle 20, S. Cerevisiae, Homolog)1     CDC20 Cell Division Cycle 20 Homolog2
CDC20 Cell Division Cycle 20 Homolog (S. Cerevisiae)1     Cell Division Cycle 20 Homolog2
Cell Division Cycle 20 Homolog (S. Cerevisiae)1     Cell Division Cycle Protein 20 Homolog2

External Ids:    HGNC: 17231   Entrez Gene: 9912   Ensembl: ENSG000001173997   OMIM: 6036185   UniProtKB: Q128343   

Export aliases for CDC20 gene to outside databases

Previous GC identifers: GC01P043767 GC01P042825 GC01P043254 GC01P043237 GC01P043208 GC01P043493 GC01P043597 GC01P041944


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC20 Gene:
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the
cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and
chromosome separation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC20 Gene: 
CDC20 (cell division cycle 20) is a protein-coding gene. Diseases associated with CDC20 include pandas, and ataxia telangiectasia, and among its related super-pathways are Mitotic Spindle Checkpoint and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include protein C-terminus binding and enzyme binding. An important paralog of this gene is FZR1.

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may
confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C
ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The
CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the
presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic
differentiation

Gene Wiki entry for CDC20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC20 gene promoter:
         MZF-1   p53   AML1a   HTF   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC20 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

CDC20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043824:  view genomic region     (about GC identifiers)

Start:
43,824,626 bp from pter      End:
43,828,874 bp from pter
Size:
4,249 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834 (See protein sequence)
Recommended Name: Cell division cycle protein 20 homolog  
Size: 499 amino acids; 54723 Da
Subunit: Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2 (By
similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL.
May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
spindle pole
Developmental stage: Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly
degraded at M/G1 transition
3 PDB 3D structures from and Proteopedia for CDC20:
4GGA (3D)        4GGC (3D)        4GGD (3D)    
Secondary accessions: B2R6Z6 D3DPJ1 Q5JUY4 Q9BW56 Q9UQI9

Explore the universe of human proteins at neXtProt for CDC20: NX_Q12834

Explore proteomics data for CDC20 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41;
    Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2
  • UniProtKB: Dephosphorylated by CTDP1
  • UniProtKB: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading
    to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C.
    Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability
    to bind the APC/C complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12834

  • CDC20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC20 Protein Expression
    REFSEQ proteins: NP_001246.2  
    ENSEMBL proteins: 
     ENSP00000308450   ENSP00000361540  
    Reactome Protein details: Q12834
    Human Recombinant Protein Products for CDC20: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDC20
    OriGene Protein Over-expression Lysate for CDC20
    OriGene MassSpec for CDC20 
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    GenScript Custom Purified and Recombinant Proteins Services for CDC20
    Novus Biologicals CDC20 Proteins
    Novus Biologicals CDC20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC20 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005680colocalizes with anaphase-promoting complex IDA11459825
    GO:0005813centrosome IEA--
    GO:0005819spindle TAS7513050

    CDC20 for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC20 
    Cloud-Clone Corp. CLIAs for CDC20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q12834

    ProtoNet protein and cluster: Q12834

    2 Blocks protein domains:
    IPB000002 Cdc20/Fizzy
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
    Similarity: Belongs to the WD repeat CDC20/Fizzy family
    Similarity: Contains 7 WD repeats


    CDC20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC20_HUMAN, Q12834
    Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may
    confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C
    ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The
    CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the
    presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic
    differentiation

         Genatlas biochemistry entry for CDC20:
    cell division cycle 20,involved in ubiquitin mediated proteolysis,highly expressed in proliferating cells,homolog
    to S cerevisiae Cdc20p,mediating the association of the mitotic spindle checkpoint protein MAD1L1 with the
    cyclosome/anaphase-promoting complex

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11030144
    GO:0008022protein C-terminus binding IPI10700282
    GO:0019899enzyme binding IPI17443180
         
    CDC20 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CDC20:
     Cell cycle / mitosis defect  Increased G2M DNA content  Increased Salmonella enterica   Increased cell death HMECs cel 
     Increased number of mitotic ce 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cdc20):
     cellular  digestive/alimentary  embryogenesis  growth/size  integument 
     mortality/aging  no phenotypic analysis  other  reproductive system  tumorigenesis 

    CDC20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDC20: Cdc20tm1.2Mama Cdc20tm1Jvd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDC20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDC20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC20 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC20 

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC20

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CDC20

    Clone
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    OriGene clones in human, mouse for CDC20 (see all 8)
    OriGene ORF clones in mouse, rat for CDC20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDC20 (NM_001255)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20
    Sirion Biotech Customized lentivirus for stable overexpression of CDC20 
                         Customized lentivirus expression plasmids for stable overexpression of CDC20 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC20 About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Mitotic Spindle Checkpoint0.95
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    Common schema of ubiquitination0.36
    APC-Cdc20 mediated degradation of Nek2A0.78
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    APC/C-mediated degradation of cell cycle proteins0.94
    SCF-beta-TrCP mediated degradation of Emi10.91
    5M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CDC20
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation
    Meiosis
    Common schema of ubiquitination

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDC20
        Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for CDC20
        Cell Cycle / Checkpoint Control
    Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for CDC20
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for CDC20
        Cell cycle
    PLK1 signaling events

    5/30        Reactome Pathways for CDC20 (see all 30)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    SCF-beta-TrCP mediated degradation of Emi1
    APC/C:Cdc20 mediated degradation of mitotic proteins
    Cell Cycle


    5         Kegg Pathways  (Kegg details for CDC20):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    HTLV-I infection
    Viral carcinogenesis

    UniProtKB/Swiss-Prot: CDC20_HUMAN, Q12834
    Pathway: Protein modification; protein ubiquitination


    CDC20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/730 Interacting proteins for CDC20 (Q128341, 2, 3 ENSP000003084504) via UniProtKB, MINT, STRING, and/or I2D (see all 730)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L1Q132571, 2, 3, ENSP000002965094EBI-367462,EBI-78203 MINT-8183760 MINT-8289337 MINT-8284921 MINT-2211306 MINT-8183848 MINT-8413025 MINT-8284907 MINT-8289292 I2D: score=6 STRING: ENSP00000296509
    CDC27P302601, 2, 3EBI-367462,EBI-994813 MINT-8289337 MINT-7947479 I2D: score=5 
    CDC16Q130422, 3, ENSP000003485544MINT-7947479 I2D: score=4 STRING: ENSP00000348554
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7947479 I2D: score=3 STRING: ENSP00000339109
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=3 STRING: ENSP00000314004
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007049cell cycle TAS9682218
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0008284positive regulation of cell proliferation IEA--

    CDC20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDC20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC20

    3 Novoseek inferred chemical compound relationships for CDC20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 50 1 11030144 (1)
    serine 9.87 1 20034488 (1)
    threonine 9.67 1 20034488 (1)

    Search CenterWatch for drugs/clinical trials and news about CDC20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC20 gene: 
    NM_001255.2  

    Unigene Cluster for CDC20:

    Cell division cycle 20
    Hs.524947  [show with all ESTs]
    Unigene Representative Sequence: BG256659
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310955(uc001cix.3) ENST00000372462(uc001ciy.3) ENST00000478882
    ENST00000482046
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC20
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC20

    Additional mRNA sequence: 

    AF099644.1 AK225504.1 AK302539.1 AK303844.1 AK312780.1 BC000624.2 BC001088.2 BC006272.2 
    BC009425.1 BC009426.1 BC010044.2 BC012803.2 BC012827.2 BC013303.2 BC015998.1 BC024257.1 
    BC031294.1 BC110321.1 BT007388.1 U05340.1 

    20 DOTS entries:

    DT.40260876  DT.92459081  DT.95118114  DT.100886629  DT.121444968  DT.100886607  DT.75124643  DT.121444946 
    DT.92459114  DT.95118133  DT.100829532  DT.92409509  DT.95246487  DT.100886608  DT.121444971  DT.40117267 
    DT.95118100  DT.95118107  DT.95118109  DT.86851862 

    24/540 AceView cDNA sequences (see all 540):

    CR591723 BI042960 BF809124 BQ642126 CR622481 BU167726 BG747016 BE672104 
    BM802806 BE293705 BQ062052 AA411428 AI863688 BQ224436 BI042977 BI871005 
    BM791597 CR604441 BG059626 CD243830 BF968507 CR611701 BM801042 BC012827 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC20 expression in normal human tissues (normalized intensities)      CDC20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCCTTCA
    CDC20 Expression
    About this image


    CDC20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical cord blood-derived mesenchymal stem cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Uterus
             uterus, pre-menopause ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood endothelial colony-forming cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   

    See CDC20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC20

    SOURCE GeneReport for Unigene cluster: Hs.524947
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDC20: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC20 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc201 , 5 cell division cycle 20 homolog (S. cerevisiae)5
    cell division cycle 201
    88.31(n)1
    94.79(a)1
      4 (54.61 cM)5
    1079951  NM_023223.21  NP_075712.21 
     1184329015 
    chicken
    (Gallus gallus)
    Aves CDC201 cell division cycle 20 homolog (S. cerevisiae) 77(n)
    82.09(a)
      424563  NM_001006536.1  NP_001006536.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC206
    Uncharacterized protein
    76(a)
    1 ↔ 1
    4(107264925-107280582)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF034578.12   -- 75.7(n)    AF034578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.263372 Danio rerio cDNA clone MGC63536 IMAGE3815834, complete more 75.12(n)    BC054907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fzy1 , 3 cyclin catabolism3
    fizzy1
    49(a)3
    56.55(n)1
    54.58(a)1
      349681  NM_058153.31  NP_477501.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC20(YGL116W)4
    CDC201
    Cell-cycle regulated activator of anaphase-promoting more4
    Cdc20p1
    47.37(n)1
    38.92(a)1
      7(289809-291641)4
    8527621, 4  NP_011399.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G275701 cell division cycle 20, cofactor of APC complex 54.97(n)
    52(a)
      832817  NM_122639.1  NP_198109.1 
    rice
    (Oryza sativa)
    Liliopsida Os.265752 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.94(n)    AK102954.1 


    ENSEMBL Gene Tree for CDC20 (if available)
    TreeFam Gene Tree for CDC20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC20 gene
    FZR12  CDC20B2  
    2 SIMAP similar genes for CDC20 using alignment to 1 protein entry:     CDC20_HUMAN:
    FZR1    CDC20B

    CDC20 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDC20
    PGOHUM00000236675


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 SNPs in CDC20 are shown (see all 169)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0303684
    ----see VAR_0303682 V M mis40--------
    VAR_0303694
    ----see VAR_0303692 R Q mis40--------
    rs17499601,2
    C,F,A,H--43822664(+) AACCAC/TGACAA 1 -- us2k16Minor allele frequency- T:0.41WA NA EA 368
    rs17499611,2
    C,F,A,H--43822665(+) ACCATC/GACAAC 1 -- us2k17Minor allele frequency- G:0.41NA WA EA 370
    rs2015397441,2
    --43822769(+) CATAT-/CCCCCC 1 -- us2k10--------
    rs120759881,2
    C,F--43822885(+) CCAACT/ATGACA 1 -- us2k17Minor allele frequency- A:0.13NS WA 296
    rs1463343701,2
    --43822984(+) GAGAAG/TGCAAA 1 -- us2k10--------
    rs1133835621,2
    F--43823029(+) GCATCG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1810964711,2
    --43823088(+) CAGTAC/TAGCGT 1 -- us2k10--------
    rs1860233321,2
    --43823346(+) TCGGCA/TCACTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC20 (43824626 - 43828874 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDC20: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603618    OMIM disorders: --

    18 diseases for CDC20:    About MalaCards
    pandas    ataxia telangiectasia    oral cancer    lung adenocarcinoma
    ataxia    retinoblastoma    ovarian cancer    prostate cancer
    glioblastoma    prostatitis    gastric cancer    pancreatic cancer
    adenocarcinoma    pancreatitis    breast cancer    hepatocellular carcinoma
    lung cancer    neuronitis


    CDC20 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CDC20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 16.7 9 17873905 (3), 17456764 (2), 16777988 (1), 18059335 (1) (see all 5)
    cancer lung 0 1 10439037 (1)
    primary tumor 0 1 16428479 (1)
    breast cancer 0 3 16428479 (1)
    tumors 0 12 16777988 (3), 17598981 (2), 12631597 (1), 17873905 (1) (see all 6)
    prostate cancer 0 6 14710249 (4)

    Genetic Association Database (GAD): CDC20
    Human Genome Epidemiology (HuGE) Navigator: CDC20 (2 documents)

    Export disorders for CDC20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC20 gene, integrated from 9 sources (see all 251):
    (articles sorted by number of sources associating them with CDC20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. (PubMed id 7513050)1, 2, 3 Weinstein J.... Baum L.G. (1994)
    2. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (PubMed id 15525512)1, 2, 9 Tang Z....Yu H. (2004)
    3. MAD2B is an inhibitor of the anaphase-promoting complex. (PubMed id 11459826)1, 2, 9 Chen J. and Fang G. (2001)
    4. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2, 9 Kraft C....Peters J.-M. (2003)
    5. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (PubMed id 9637688)1, 2, 9 Fang G.... Kirschner M.W. (1998)
    6. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)1, 2, 9 Stegmeier F....Elledge S.J. (2007)
    7. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (2012)
    8. APC15 drives the turnover of MCC-CDC20 to make the sp indle assembly checkpoint responsive to kinetochore attachment. (PubMed id 21926987)1, 2 Mansfeld J....Pines J. (2011)
    9. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    10. CDK5RAP2 is required for spindle checkpoint function. (PubMed id 19282672)1, 2 Zhang X....Xu X. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 991 HGNC: 1723 AceView: CDC20 Ensembl:ENSG00000117399 euGenes: HUgn991
    ECgene: CDC20 Kegg: 991 H-InvDB: CDC20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC20 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc20/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC20 gene:
    Search GeneIP for patents involving CDC20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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