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CDC2 Gene

protein-coding GIFtS: 74

GC10P062208

cell division cycle 2, G1 to S and G2 to M
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDC28A ^¹, ²
CDK1 ^², ³, ⁵
DKFZp686L20222 ^²
EC 2.7.11.22,EC 2.7.11.23 ^³
MGC111195 ^²
OTTHUMP00000019660 ^²

Descriptions
Cyclin-dependent kinase 1 ^², ³
cell cycle controller CDC2 ^²
cell division control protein 2 homolog ^²
cell division cycle 2 ^²
cell division cycle 2, G1 to S and G2 to M ^²
p34 protein kinase ^², ³

External Ids
HGNC: 1722¹
Entrez Gene: 983²
UniProtKB: P06493³
Ensembl: ENSG00000170312⁷

Search outside databases for aliases for CDC2 gene

Previous GC identifers: GC10P061334 GC10P061563 GC10P062430 GC10P061882

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDC2:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is

a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting

factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle.

Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase

activity of this protein is controlled by cyclin accumulation and destruction through the cell

cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory

roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms

have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDC2_HUMAN, P06493

Function: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher

cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that

phosphorylates the repetitive C-terminus of RNA polymerase II

Gene Wiki entry for CDC2 (Cdk1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDC2 gene

Entrez Gene cytogenetic band: 10q21.1 Ensembl cytogenetic band: 10q21.2 HGNC cytogenetic band: 10q21.1

CDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P062208: (about GC identifiers)

Start:	62,205,690 bp from pter
End:	62,224,616 bp from pter
Size:	18,927 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CDC2_HUMAN, P06493 (See protein sequence)

Recommended Name: Cell division control protein 2 homolog

Size: 297 amino acids; 34095 Da

Subunit: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.

Interacts with DLGAP5. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the

CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an

endocytotic complex during interphase

Subcellular location: Nucleus (By similarity)

PDB structures from and Proteopedia :

1LC9 (3D)

Secondary accessions: A8K7C4 O60764

Alternative splicing: 2 isoforms: P06493-1 P06493-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001124301.1 NP_001777.1 NP_203698.1

ENSEMBL proteins:

ENSP00000362915 ENSP00000362917 ENSP00000306043 ENSP00000325970 ENSP00000378699

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CDC2
	Millipore Purified and/or Recombinant CDC2 Protein
	Sigma-Aldrich Proteins for CDC2
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDC2
	Recombinant Proteins from Abcam (Cdk1 + Cdk2, Cdc2 , CDK1 + Cyclin A2, Cdks)
	Human Recombinant Proteins from Abnova (CDC2)

OriGene Purified Recombinant Human Protein: CDC2

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	EXP	1384126 1717476 1828290 7799941 7969176 10395539 11598127 12791267
GO:0005737	cytoplasm	IDA	18029348
GO:0005829	cytosol	EXP	1717476 9001210 10395539 11285280
GO:0005876	spindle microtubule	IDA	11069302

About this table

Antibodies for CDC2:

	Invitrogen Antibodies for CDC2
	Millipore Mono- and Polyclonal Antibodies for the study of CDC2
	Sigma-Aldrich Antibody Arrays and Antibodies for CDC2
	R&D Systems Antibodies for CDC2
	Cell Signaling Technology (CST) Antibodies for CDC2
	Antibodies from Abcam (Cdk1 + Cdk2, Cdc2 , CDK1 + Cyclin A2, Cdks), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CDC2

Assays for CDC2:

	Invitrogen Assays for CDC2
	Millipore Kits and Assays for the Analysis of CDC2
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for CDC2
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06493

ProtoNet protein and cluster: P06493

UniProtKB/Swiss-Prot: CDC2_HUMAN, P06493

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC2)
		Millipore RNAi Products for the Analysis of CDC2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDC2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130829

Applied Biosystems Silencer® siRNAs for CDC2

Sigma-Aldrich siRNA and siRNA Panels for CDC2

Sigma-Aldrich shRNA Panels and shRNA for CDC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDC2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130829
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130829
untagged cDNA clones in CMV expression vector (see all 4): NM_001130829

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001786

UniProtKB/Swiss-Prot: CDC2_HUMAN, P06493

Function: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher

cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that

phosphorylates the repetitive C-terminus of RNA polymerase II

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase]

phosphate

Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while

phosphorylation at Thr-161 activates it

Enzyme Number (IUBMB): EC 2.7.11.22,EC

Genatlas biochemistry entry for CDC2:

cyclin dependent kinase (CDK1),involved in cell cycle regulation (G1 to S and G2 to M

transition),activated by CDC25 phosphatase and acting as an histone 1-kinase (H1K), complexing

with cyclin B1 (M phase promoting factor (MPF) component) and continually shuttling between the

nucleus and cytoplasm,maintained in an inactive state by phosphorylation by WEE1 and MYT1,required

for fragmentation in mitosis through interaction with the cis-Golgi matrix protein GM130,putative

up-regulated c-Myc target gene

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdc2a):

endocrine/exocrine gland

lethality-prenatal/perinatal

normal

reproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004693	cyclin-dependent protein kinase activity	IDA	11069302
GO:0005515	protein binding	IPI	11069302
GO:0005524	ATP binding	IEA	--
GO:0008353	RNA polymerase subunit kinase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for CDC2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Role of CHK Proteins in Cell Cycle Checkpoint Control
Cell Cycle: G2/M DNA Damage Checkpoint Regulation
Mitotic Roles of Polo-Like Kinase
ATM Signaling
Inositol Phosphate Metabolism

GeneDecks CDC2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDC2

5/303 Interacting proteins for CDC2 (P06493^{1, 2} ENSP00000362917³) via UniProtKB, MINT, and/or STRING (see all 303 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947², ENSP00000340989³	MINT-15829 MINT-15830 STRING (score=.96)
CDC25C	P30307¹, ENSP00000321656³	EBI-444308, EBI-974439 STRING (score=.999)
MYT1	Q01538¹, ENSP00000327465³	EBI-444308, EBI-515143 STRING (score=.992)
NDE1	Q9NXR1¹, ENSP00000345892³	EBI-444308, EBI-941227 STRING (score=.986)
FOXO1	Q12778¹, ENSP00000368880³	EBI-444308, EBI-1108782 STRING (score=.977)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0006916	anti-apoptosis	IDA	11069302
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP	11285280

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDC2

Sigma-Aldrich Small Molecules for CDC2:

Inhibitor

Compounds for CDC2 available from Tocris Bioscience

Compound	Action	CAS number
Olomoucine	Cyclin-dependent kinase inhibitor	[101622-51-9]
Purvalanol B	Cyclin-dependent kinase inhibitor	[212844-54-7]
NU 2058	Cdk1 and cdk2 inhibitor	[161058-83-9]
Apigenin	Protein kinase inhibitor	[520-36-5]
Purvalanol A	Cyclin-dependent kinase inhibitor	[212844-53-6]

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10/61 Novoseek chemical compound relationships for CDC2 gene (see all 61 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nu2058	80.43	3	10956187 (1), 17599054 (1)
pstair	69.54	4	8407941 (2), 1833185 (1)
alsterpaullone	68.73	2	15362121 (1), 14726692 (1)
tetra-o-methylnordihydroguaiaretic acid	64.20	2	17454637 (2)
indirubin-3monoxime	63.48	2	16827155 (1), 11161389 (1)
purvalanol a	61.35	1	10956385 (1)
threonine	57.47	37	8485236 (2), 9400990 (2), 1833185 (1), 15686453 (1) (see all 25)
tyrosine	47.41	91	9486797 (5), 12472573 (3), 1825803 (3), 10098730 (3) (see all 58)
okadaic acid	45.93	23	9618275 (4), 7622588 (4), 16317763 (4), 12397081 (2) (see all 9)
imidazo[1,2-a]pyridine	44.70	1	16397259 (1)

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4 PharmGKB drug compound relationships for CDC2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	CO FA	12973835
cyclophosphamide	CO FA	12973835
mercaptopurine	PD FA GN	12704389
methotrexate	CO PD FA GN	12704389 12973835

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDC2)
		Millipore RNAi Products for the Analysis of CDC2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDC2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130829

Sigma-Aldrich siRNA and siRNA Panels for CDC2

Sigma-Aldrich shRNA Panels and shRNA for CDC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130829 NM_001786 NM_033379

REFSEQ mRNAs for CDC2 gene (3 alternative transcripts):

NM_001130829.1 NM_001786.3 NM_033379.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130829 NM_001786 NM_033379

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130829
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130829
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001130829

Additional cDNA sequence:

AK027271.1 AK291939.1 AK295741.1 BC014563.1 BT007004.1 CR595214.1 CR597955.1 CR603310.1

CR933728.1 D88357.1 X05360.1 Y00272.1

8 DOTS entries:

DT.455976 DT.99984670 DT.100019020 DT.87046806 DT.97824850 DT.121298371 DT.100781022 DT.121298359

24/183 AceView cDNA sequences (see all 183 ):

AA278152 AF055880 AA278384 BU538964 BC014563 BM982777 AA460417 CR597955

AA598974 BG684341 AI608775 CA423827 BU625310 AL520473 AV716477 AU280243

AA313715 CR595214 BX342068 CR603310 BF968871 BE252934 BU633268 BT007004

highest scoring ESTs for CDC2:

D88357 X05360 Y00272 AA262523 AA278152 AA278928 AA309053 AA309870 AA405362 AA460416

Unigene Cluster for CDC2:

Cell division cycle 2, G1 to S and G2 to M

Hs.334562 [show with all ESTs]

Unigene Representative Sequence: CR933728

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDC2 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c
SP1:					-										-		-
SP2:															-		-										-
SP3:															-		-										-
SP4:			-		-										-		-
SP5:															-		-		-		-						-

About this scheme

ECgene alternative splicing isoforms for CDC2

5 Ensembl transcripts including schematic representations:

ENST00000373809 ENST00000373811 ENST00000307250 ENST00000316629 ENST00000395284

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDC2

¹ / ² / ³

10 probe-sets matching CDC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1803_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.41	X05360	1.00	1.00	1.00	1
33324_s_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.80	D88357	1.00	1.00	1.00	1
40915_r_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.57	Y00272	1.00	1.00	1.00	1
91194_at²^{, 3}	U95-E	1	1.00	1.00	0.86	1.49	AF154332	0.80	1.00	0.91	1
203214_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001786	0.60	1.00	0.82	1
210559_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D88357	1.00	1.00	1.00	1
203213_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL524035	0.60	1.00	0.82	1
203214_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210559_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203213_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDC2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.334562
Expression variation in blood from EXPOLDB for CDC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC2 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDC2¹	--	cell division cycle 2, G1 to S and G2 to M	95.74(n) 99.33(a)	488997 XM_844357.1 XP_849450.1
chimpanzee (Pan troglodytes)	CDC2¹	--	cell division cycle 2, G1 to S and G2 to M	99.89(n) 100(a)	450481 XM_001164695.1 XP_001164695.1
cow (Bos taurus)	CDC2¹	--	cell division cycle 2, G1 to S and G2 to M	95.29(n) 98.65(a)	281061 NM_174016.2 NP_776441.1
rat (Rattus norvegicus)	Cdc2¹	--	cell division cycle 2, G1 to S and G2 to M	84.62(n) 97.64(a)	54237 NM_019296.1 NP_062169.1
mouse (Mus musculus)	Cdc2a^{1, 5}	10 (38.00 cM)⁵	cell division cycle 2 homolog A (S. pombe)^{1, 5}	86.08(n)¹ 96.97(a)¹	12534¹ NM_007659.3¹ NP_031685.2¹ AF488732⁵ AK030231⁵ (see all 15)

About this table Species with no ortholog for CDC2

ENSEMBL Gene Tree for CDC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDC2 gene

CDK3² CDK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/164 NCBI SNPs in CDC2 are shown (see all 164 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 122)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2127355^1,2	A,C,F,H,O	62204222(+)	`TTGACG/ATATGA`	1	--	ng5¹		12	EA NA EU WA	1050
	rs10711^1,2	A,C,F,H,O	62224480(+)	`AGGAGT/GTGCTT`	3	--	ut3¹		17	NS MN NA EU EA WA	1730
	rs2448343^1,2	A,C,F,H,O	62209650(+)	`GGGTTG/ATTTTG`	2	--	int¹ ng5¹		8	NS NA EU EA WA	726
	rs2170006^1,2	A,C,F,H	62204620(+)	`TTTCCA/GGCAAC`	1	--	ng5¹		8	EU EA WA	838
	rs1871446^1,2	A,C,F,H	62223769(-)	`GTTGAC/TATAAC`	3	--	ut3¹ ese³		12	EU EA WA NS NA	1144
	rs1060373^1,2	C,F,H	62224506(+)	`TCTGAG/ATTTAA`	3	--	ut3¹ ese³		33	NS MN EU EA WA NA	3002
	rs2260179^1,2	C,F,H	62209794(+)	`GAATAC/GTTATG`	2	--	ng5¹ int¹		9	NS EU EA WA	996
	rs3213025^1,2	C,F,H	62209197(+)	`TTTTCT/CGCTTA`	2	--	ng5¹ int¹		12	NS EU EA WA NA	1126
	rs7907695^1,2	F,H	62204882(+)	`ATTCAC/TGTGGC`	1	--	ng5¹ tfbs³		4	EU EA WA	382
	rs3213021^1,2	F,H	62208729(+)	`CGCGCC/GCTGCC`	2	--	ng5¹ int¹		5	NS EU EA WA	540

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HapMap Linkage Disequilibrium images for CDC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116940

10/60 Novoseek disease relationships for CDC2 gene (see all 60 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	73.12	34	16465393 (4), 1756735 (1), 8876167 (1), 14674679 (1) (see all 30)
cancer	54.11	36	8318919 (3), 15645429 (2), 16687918 (2), 17481885 (2) (see all 25)
tumors	51.02	70	17434927 (3), 18069625 (3), 14696091 (2), 15958646 (2) (see all 49)
colon cancer	39.73	4	10216486 (2), 15001986 (1), 16024531 (1)
prostate cancer	35.93	18	17070313 (3), 17043241 (2), 15961392 (1), 14652289 (1) (see all 10)
promyelocytic leukemia	33.93	2	16619512 (1), 8936337 (1)
myeloid leukemia	33.39	2	18505930 (1), 17636382 (1)
cervical carcinoma	32.71	1	9201712 (1)
colon carcinoma	29.29	1	19223178 (1)
breast cancer	29.05	17	9515786 (2), 11720835 (2), 9664138 (1), 12429981 (1) (see all 14)

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2 PharmGKB disease relationships for CDC2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	CO FA	12973835
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Genetic Association Database: CDC2
Human Genome Epidemiology Navigator: CDC2 (6 documents)
Tumor Gene Database: CDC2

(Possibly Related Articles in Doctor's Guide)
About This Section

Novel Transcription Inhibitor Shows Benefits for Patients With Cervical Intraepithelial Neoplasia: Presented at AACR-NCI-NORTC

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1149 PubMed articles for CDC2 gene (see all 1149 ):

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (PubMed id 3553962)^{2, 3, 4} Lee M.G. and Nurse P. (1987)
Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease. (PubMed id 16192727)^{1, 3, 6} Johansson A....Blennow K. (2005)
Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia. (PubMed id 12648761)^{1, 3, 6} Johansson A....Blennow K. (2003)
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. (PubMed id 9515786)^{1, 3, 4} Ohta T....Xiong Y. (1998)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B- phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. (PubMed id 15145941)^{3, 4} Hsu J.-M.... Huang C.-Y.F. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 983	HGNC: 1722	AceView: CDC2	Ensembl:ENSG00000170312	euGenes: HUgn983
ECgene: CDC2	H-InvDB: CDC2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDC2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc2/

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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CDC2 Gene

protein-coding GIFtS: 74

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDC2 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor CDC2

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Genomic Locationfor CDC2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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for CDC2

Genomic Location
for CDC2

Proteins
for CDC2

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for CDC2

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for CDC2

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