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CDC16 Gene

protein-coding   GIFtS: 65
GCID: GC13P115000

Cell Division Cycle 16

(Previous names: CDC16 (cell division cycle 16, S. cerevisiae, homolog),...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 161 2     CDC16 Cell Division Cycle 16 Homolog (S. Cerevisiae)1
APC62 3 5     Cell Division Cycle 16 Homolog (S. Cerevisiae)1
Anaphase-Promoting Complex Subunit 62 3     Subunit 61
Cyclosome Subunit 62 3     CUT92
ANAPC62 3     Anaphase-Promoting Complex, Subunit 62
CDC16Hs2 3     Cell Division Cycle 16 Homolog2
Anaphase-Promoting Complex1     Cell Division Cycle Protein 16 Homolog2
CDC16 (Cell Division Cycle 16, S. Cerevisiae, Homolog)1     CDC16 Homolog3

External Ids:    HGNC: 17201   Entrez Gene: 88812   Ensembl: ENSG000001301777   OMIM: 6034615   UniProtKB: Q130423   

Export aliases for CDC16 gene to outside databases

Previous GC identifers: GC13P113361 GC13P111188 GC13P114022 GC13P112918 GC13P114018 GC13P095262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC16 Gene:
This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a
protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each
component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other
APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be
involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have
been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDC16 Gene:
CDC16 (cell division cycle 16) is a protein-coding gene.

UniProtKB/Swiss-Prot: CDC16_HUMAN, Q13042
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for CDC16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024498.13  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC16 gene promoter:
         Max1   Sox5   ATF-2   Nkx5-1   S8   HSF2   Sox9   TGIF   ATF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC16 promoter sequence
   Search Chromatin IP Primers for CDC16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

CDC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC16 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P115000:  view genomic region     (about GC identifiers)

Start:
115,000,362 bp from pter      End:
115,038,198 bp from pter
Size:
37,837 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDC16_HUMAN, Q13042 (See protein sequence)
Recommended Name: Cell division cycle protein 16 homolog  
Size: 620 amino acids; 71656 Da
Subunit: The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20
1 PDB 3D structure from and Proteopedia for CDC16:
3HYM (3D)    
Secondary accessions: A2A365 Q5T8C8 Q96AE6 Q9Y564
Alternative splicing: 3 isoforms:  Q13042-1   Q13042-2   Q13042-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC16: NX_Q13042

Explore proteomics data for CDC16 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis1
  • Ubiquitination2 at Lys106, Lys154, Lys423
  • Modification sites at PhosphoSitePlus

  • See CDC16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001072113.1  NP_003894.3  

    ENSEMBL proteins: 
     ENSP00000348554   ENSP00000364459   ENSP00000252457   ENSP00000364457   ENSP00000252458  
     ENSP00000353549   ENSP00000364461  
    Reactome Protein details: Q13042

    CDC16 Human Recombinant Protein Products:

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    Novus Biologicals CDC16 Proteins
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q13042

    ProtoNet protein and cluster: Q13042

    UniProtKB/Swiss-Prot: CDC16_HUMAN, Q13042
    Similarity: Belongs to the APC6/CDC16 family
    Similarity: Contains 7 TPR repeats


    Find genes that share domains with CDC16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDC16_HUMAN, Q13042
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CDC16           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDC16:
     Cell division defect  Increased cell death in HCT116  Increased cell number in S  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC16
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    miRNA
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    miRTarBase miRNAs that target CDC16:
    hsa-mir-93-5p (MIRT048910)

    Block miRNA regulation of human, mouse, rat CDC16 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CDC16:
    hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDC16 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC16

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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC16 (NM_003903)
    Sino Biological Human cDNA Clone for CDC16
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC16

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDC16_HUMAN, Q13042: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    endosome2
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA7736578

    Find genes that share ontologies with CDC16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC16 About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with CDC16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDC16 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for CDC16
        Cell Cycle / Checkpoint Control
    Protein Stability

    Selected GeneGo (Thomson Reuters) Pathways for CDC16 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for CDC16
        TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for CDC16 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for CDC16):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: CDC16_HUMAN, Q13042
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC16: 

              Cell Cycle in human mouse rat
              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC16 (Q130421, 2, 3 ENSP000003485544) via UniProtKB, MINT, STRING, and/or I2D (see all 1010)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007088regulation of mitosis TAS7736578
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0008283cell proliferation TAS7736578

    Find genes that share ontologies with CDC16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDC16 gene (2 alternative transcripts): 
    NM_001078645.1  NM_003903.3  

    Unigene Cluster for CDC16:

    Cell division cycle 16
    Hs.374127  [show with all ESTs]
    Unigene Representative Sequence: AK095082
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356221 ENST00000375310 ENST00000494766(uc010tkm.1) ENST00000252457
    ENST00000375308 ENST00000252458 ENST00000484907 ENST00000494581 ENST00000461716
    ENST00000360383(uc001vuk.1 uc001vul.1 uc001vum.1 uc001vun.1)
    ENST00000375312(uc001vuo.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CDC16:
    hsa-miR-299-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDC16 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDC16 (NM_003903)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC16
      QuantiTect SYBR Green Assays in human, mouse, rat CDC16
      QuantiFast Probe-based Assays in human, mouse, rat CDC16

    Additional mRNA sequence: 

    AF164598.1 AK095082.1 AK296424.1 AK315302.1 BC010875.2 BC017244.1 BC050575.1 U18291.1 

    24 DOTS entries:

    DT.91770418  DT.100044735  DT.100821770  DT.95161341  DT.307591  DT.120769459  DT.91770435  DT.100821762 
    DT.91770417  DT.91770423  DT.97806699  DT.120769485  DT.100821763  DT.91866246  DT.100044733  DT.100811603 
    DT.120769506  DT.92023836  DT.95161343  DT.97796741  DT.99960725  DT.120769466  DT.120769488  DT.120769477 

    Selected AceView cDNA sequences (see all 339):

    AA450275 CD243371 AA778593 BU633373 AA534681 BQ574225 AW662777 BU182223 
    CD245386 AW952989 BQ221870 BU077860 CB305872 AA906480 BX282171 BM670644 
    BU158464 BX447379 AI279055 BU683268 AW130961 BC010875 BQ009960 BQ956932 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC16 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                                              -           -                                               -           -     -           -   
    SP2:                                      -                       -           -                                               -           -     -           -   
    SP3:                                      -                       -           -                                               -           -     -           -   
    SP4:                                      -                       -           -                                   -     -     -           -     -           -   
    SP5:                                                                                                                          -           -     -           -   

    ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b · 19c · 19d ^ 20
    SP1:  -                 -                                       
    SP2:  -                 -                                       
    SP3:  -                 -                                       
    SP4:  -                 -                                       
    SP5:  -                                                         


    ECgene alternative splicing isoforms for CDC16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDC16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTAGAGA
    CDC16 Expression
    About this image


    CDC16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDC16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374127
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC16: 
              Cell Cycle in human mouse rat
              Adherens Junctions in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDC16 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc161 , 5 CDC16 cell division cycle 16 homolog (S. cerevisiae)5
    CDC16 cell division cycle 161
    88.23(n)1
    95.48(a)1
      8 (6.38 cM)5
    699571  NM_027276.21  NP_081552.21 
     137576765 
    chicken
    (Gallus gallus)
    Aves CDC161 cell division cycle 16 homolog (S. cerevisiae) 83.23(n)
    92.1(a)
      418735  NM_001006265.1  NP_001006265.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC166
    cell division cycle 16
    86(a)
    1 ↔ 1
    3(106757007-106777810)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238062 Xenopus laevis transcribed sequence with moderate similarity more 83.7(n)    BQ735960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc161 cell division cycle 16 homolog (S. cerevisiae) 72.29(n)
    81.34(a)
      562014  NM_001037389.1  NP_001032466.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc161 , 3 mitotic anaphase ubiquitin-protein
    ligase3
    cdc161
    50(a)3
    51.54(n)1
    46.67(a)1
      94E93
    427531  NM_058049.51  NP_477397.11 
    worm
    (Caenorhabditis elegans)
    Secernentea emb-273   -- 24(a)   II(8159851-8162091)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC16(YKL022C)4
    CDC161
    Subunit of the anaphase-promoting complex/cyclosome more4
    CDC161
    46.27(n)1
    33.98(a)1
      11(397248-394726)4
    8538461, 4  NP_012903.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC61 APC6 52.01(n)
    44.36(a)
      844213  NM_106524.2  NP_565188.1 


    ENSEMBL Gene Tree for CDC16 (if available)
    TreeFam Gene Tree for CDC16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC16 (see all 947)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889227951,2
    --114998566(+) ACACAC/GATAGA 2 -- us2k10--------
    rs1924114641,2
    --114998601(+) GTAGCA/GTGAGA 2 -- us2k10--------
    rs173376051,2
    C,F--114998668(+) AATTTT/CTTTTA 2 -- us2k13Minor allele frequency- C:0.04NS WA 290
    rs172908411,2
    C,F--114998761(+) TACATA/GTAGTG 2 -- us2k13Minor allele frequency- G:0.03NS NA EA 412
    rs95904031,2
    C,F,A--114998795(+) AATGGC/TCACCT 2 -- us2k116Minor allele frequency- T:0.33NA NS WA CSA EA 1200
    rs1477195201,2
    --114998827(+) CCAAGA/TGGAGC 2 -- us2k10--------
    rs172908551,2
    C,F--114998839(+) CAGGTC/TTCTCT 2 -- us2k13Minor allele frequency- T:0.04NS WA 292
    rs1845925861,2
    --114998953(+) AGGAAA/GATTGC 2 -- us2k10--------
    rs1408881951,2
    C--114998959(+) ATTGCC/GTTATA 2 -- us2k10--------
    rs173376121,2
    C,F--114998977(+) GAGGAG/CGGGTA 2 -- us2k111Minor allele frequency- C:0.06NS NA CSA EA 1080

    HapMap Linkage Disequilibrium report for CDC16 (115000362 - 115038198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CDC16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901115CNV Gain21882294
    nsv901114CNV Gain21882294
    nsv456143CNV Gain19166990
    nsv832728CNV Gain17160897
    nsv901116CNV Gain21882294
    nsv521609CNV Gain19592680
    nsv901106CNV Gain21882294
    esv25715CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC16
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603461    OMIM disorders: --


    Find genes that share disorders with CDC16           About GenesLikeMe

    Genetic Association Database (GAD): CDC16
    Human Genome Epidemiology (HuGE) Navigator: CDC16 (2 documents)

    Export disorders for CDC16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC16 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with CDC16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. (PubMed id 7736578)1, 2, 3, 9 Tugendreich S.... Hieter P. (Cell 1995)
    2. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex. (PubMed id 9405394)1, 2, 9 Ollendorff V. and Donoghue D.J. (J. Biol. Chem. 1997)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    9. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. (PubMed id 9628895)1, 2 Kallio M.... Gorbsky G.J. (J. Cell Biol. 1998)
    10. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8881 HGNC: 1720 AceView: CDC16 Ensembl:ENSG00000130177 euGenes: HUgn8881
    ECgene: CDC16 Kegg: 8881 H-InvDB: CDC16

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDC16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC16 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc16/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC16 gene:
    Search GeneIP for patents involving CDC16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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