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Aliases for CDC14C Gene

Aliases for CDC14C Gene

  • Cell Division Cycle 14C 2 3
  • CDC14 Cell Division Cycle 14 Homolog C 3 4
  • Cdc14B2 3 4
  • CDC14 Cell Division Cycle 14 Homolog C (S. Cerevisiae) 2
  • CDC14 Cell Division Cycle 14 C Pseudogene 3
  • CDC14Bretro 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for CDC14C Gene

Summaries for CDC14C Gene

GeneCards Summary for CDC14C Gene

CDC14C (Cell Division Cycle 14C) is a Pseudogene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for CDC14C Gene

  • Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC14C Gene

Genomics for CDC14C Gene

Genomic Location for CDC14C Gene

Start:
48,919,765 bp from pter
End:
48,927,453 bp from pter
Size:
7,689 bases
Orientation:
Plus strand

Genomic View for CDC14C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14C Gene

Proteins for CDC14C Gene

  • Protein details for CDC14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D256-CC14C_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14C
    Protein Accession:
    A4D256
    Secondary Accessions:
    • Q2VIP7
    • Q6NUS3
    • Q8NCT2

    Protein attributes for CDC14C Gene

    Size:
    554 amino acids
    Molecular mass:
    63299 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May act as an autosomal functional substitute

neXtProt entry for CDC14C Gene

Proteomics data for CDC14C Gene at MOPED

Post-translational modifications for CDC14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDC14C Gene

Domains for CDC14C Gene

UniProtKB/Swiss-Prot:

CC14C_HUMAN
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold:
    • A4D256
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.:
    • A4D256
genes like me logo Genes that share domains with CDC14C: view

No data available for Gene Families for CDC14C Gene

Function for CDC14C Gene

Molecular function for CDC14C Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

Enzyme Numbers (IUBMB) for CDC14C Gene

Gene Ontology (GO) - Molecular Function for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with CDC14C: view

Phenotypes for CDC14C Gene

GenomeRNAi human phenotypes for CDC14C:
genes like me logo Genes that share phenotypes with CDC14C: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDC14C Gene

Localization for CDC14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14C Gene

Membrane; Single-pass membrane protein. Nucleus, nucleolus. Note=Nucleolar during interphase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC14C Gene COMPARTMENTS Subcellular localization image for CDC14C gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDC14C: view

Pathways for CDC14C Gene

SuperPathways for CDC14C Gene

No Data Available

Interacting Proteins for CDC14C Gene

Gene Ontology (GO) - Biological Process for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with CDC14C: view

No data available for Pathways by source for CDC14C Gene

Transcripts for CDC14C Gene

mRNA/cDNA for CDC14C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC14C Gene

Cell division cycle 14C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14C Gene

No ASD Table

Relevant External Links for CDC14C Gene

GeneLoc Exon Structure for
CDC14C
ECgene alternative splicing isoforms for
CDC14C

Expression for CDC14C Gene

mRNA expression in normal human tissues for CDC14C Gene

mRNA differential expression in normal tissues according to GTEx for CDC14C Gene

This gene is overexpressed in Testis (18.5).

SOURCE GeneReport for Unigene cluster for CDC14C Gene Hs.567757

genes like me logo Genes that share expressions with CDC14C: view

Orthologs for CDC14C Gene

Evolution for CDC14C Gene

ENSEMBL:
Gene Tree for CDC14C (if available)
TreeFam:
Gene Tree for CDC14C (if available)

No data available for Orthologs for CDC14C Gene

Paralogs for CDC14C Gene

Selected SIMAP similar genes for CDC14C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC14C: view

No data available for Paralogs for CDC14C Gene

Variants for CDC14C Gene

Sequence variations from dbSNP and Humsavar for CDC14C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs365402 -- 48,924,080(-) TTGCT(C/T)TTTCA upstream-variant-2KB
rs365447 -- 48,924,037(-) TGGGG(C/G)CACAA upstream-variant-2KB
rs368220 -- 48,927,763(-) GCAGC(A/G)AAACA downstream-variant-500B
rs377773 -- 48,927,340(-) TTCCA(A/G)CTCTG nc-transcript-variant
rs378110 -- 48,927,254(-) ACCTG(A/G)TATTA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC14C Gene

Variant ID Type Subtype PubMed ID
nsv888012 CNV Gain 21882294
nsv7396 OTHER Inversion 18451855
nsv292 OTHER Inversion 15895083
esv33916 CNV Gain 17666407

Relevant External Links for CDC14C Gene

HapMap Linkage Disequilibrium report
CDC14C

Disorders for CDC14C Gene

Relevant External Links for CDC14C

Genetic Association Database (GAD)
CDC14C
genes like me logo Genes that share disorders with CDC14C: view

No data available for UniProtKB/Swiss-Prot for CDC14C Gene

Publications for CDC14C Gene

  1. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4
  2. Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. (PMID: 18547142) Rosso L. … Kaessmann H. (PLoS Biol. 2008) 2 3
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  4. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PMID: 17052657) Fung H.C. … Singleton A. (Lancet Neurol 2006) 49
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 49

Products for CDC14C Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CDC14C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CDC14C
    • Block miRNA regulation of CDC14C using miScript Target Protectors

    Sources for CDC14C Gene

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