CDC14C Gene
pseudogene GIFtS: 32
GCID: GC07P048960
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cell division cycle 14C(Previous name: CDC14 cell division cycle 14 homolog C (S. cerevisiae)...)
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Aliases
for CDC14C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cell Division Cycle 14C1 2 | | CDC14 Cell Division Cycle 14 Homolog C (S. Cerevisiae)1 | | CDC14B21 2 3 | | EC 3.1.3.163 | | CDC14Bretro1 2 | | EC 3.1.3.483 | | MGC264841 | | CDC14 Cell Division Cycle 14 Homolog C3 |
Export aliases for CDC14C gene to outside databasesPrevious GC identifers: GC07P048737 GC07P048934 GC07P049007 |
Summaries
for CDC14C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256Function: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases(By similarity)
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Genomic Views
for CDC14C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDC14C gene promoter:
POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU6F1 (c2) POU3F2 LCR-F1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDC14C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC14C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p12.3 Ensembl cytogenetic band: 7p12.3 HGNC cytogenetic band: 7p12.3CDC14C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P048960: view genomic region
(about GC identifiers)
Start:
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48,959,361 bp from pter |
End:
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48,967,049 bp from pter |
Size:
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7,689 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 49,007,656-49,010,549 |
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Proteins
for CDC14C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256 (See
protein sequence)Recommended Name: Dual specificity protein phosphatase CDC14C Size: 554 amino acids; 63299 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Nucleus, nucleolus. Note=Nucleolar duringinterphase (By similarity)
Miscellaneous: May act as an autosomal functional substitute
Secondary accessions: Q2VIP7 Q6NUS3 Q8NCT2Explore the universe of human proteins at neXtProt for CDC14C: NX_A4D256
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4D256
CDC14C Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products for CDC14C:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005730 | nucleolus |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CDC14C for ontologies About GeneDecksing
CDC14C Antibody Products:
Assay Products for CDC14C: |
Protein
Domains /
Families
for CDC14C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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CDC14C for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A4D256ProtoNet protein and cluster: A4D256 UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP)foldSimilarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily |
Function
for CDC14C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: CC14C_HUMAN, A4D256Function: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases(By similarity)Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IEA | -- |
CDC14C for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CDC14C:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14C |
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Pathways & Interactions
for CDC14C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC14C
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Drugs & Compounds
for CDC14C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDC14C
Search CenterWatch for drugs/clinical trials and news about CDC14C 
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Transcripts
for CDC14C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for CDC14C gene: NM_152627.1 Unigene Cluster for CDC14C: CDC14 cell division cycle 14 homolog C (S. cerevisiae) Hs.567757 [show with all ESTs]Unigene Representative Sequence: BC0684522 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428251 ENST00000406468
Additional cDNA sequence: BC028690.2 BC068452.1 NR_003595.1 3 DOTS entries: DT.102820247 DT.99951715 DT.454283 8 AceView cDNA sequences: BC028690 BG723382 BV198672 BC068452 BG722740 BG718843 BG722222 BI459566
GeneLoc Exon Structure
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Expression
for CDC14C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDC14C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAATACC
About this image
Genevestigator expression for CDC14C
SOURCE GeneReport for Unigene cluster: Hs.567757
SABiosciences Custom PCR Arrays for CDC14C
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDC14C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDC14C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC14C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC14C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14C |
Orthologs
for CDC14C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for CDC14C (if available)
TreeFam Gene Tree for CDC14C (if available) |
Paralogs
for CDC14C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for CDC14C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CDC14C (48959361 - 48967049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CDC14C
1 CNV: 7629
2 Inversions: 37287 0606 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CDC14C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for CDC14C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for CDC14C gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDC14C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. (PubMed id 18547142)1, 3 Rosso L....Kaessmann H. (2008)
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CDC14C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CDC14C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CDC14C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDC14C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDC14C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CDC14C gene:
Search GeneIP for patents involving CDC14C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDC14C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDC14C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC14C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC14C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC14C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC14C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDC14C |
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| | | | Search Tocris compounds for CDC14C |
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 | | | CDC14C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CDC14C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CDC14C |
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