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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC14C Gene

pseudogene   GIFtS: 32
GCID: GC07P048960

Cell Division Cycle 14C

(Previous name: CDC14 cell division cycle 14 homolog C (S. cerevisiae))
  Search for CDC14C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 14C1 2     EC 3.1.3.163
CDC14B22 3     EC 3.1.3.483
CDC14 Cell Division Cycle 14 Homolog C (S. Cerevisiae)1     CDC14 Cell Division Cycle 14 Homolog C3
CDC14Bretro2     

External Ids:    HGNC: 224271   Entrez Gene: 1684482   Ensembl: ENSG000002183057   UniProtKB: A4D2563   

Export aliases for CDC14C gene to outside databases

Previous GC identifers: GC07P048737 GC07P048934 GC07P049007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDC14C Gene: 
CDC14C (cell division cycle 14C) is a pseudogene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256
Function: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed
kinases (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC14C gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU6F1 (c2)   POU3F2   LCR-F1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CDC14C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC14C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.3   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p12.3

CDC14C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P048960:  view genomic region     (about GC identifiers)

Start:
48,959,361 bp from pter      End:
48,967,049 bp from pter
Size:
7,689 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 49,007,656-49,010,549     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14C  
Size: 554 amino acids; 63299 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Nucleus, nucleolus. Note=Nucleolar
during interphase (By similarity)
Miscellaneous: May act as an autosomal functional substitute
Secondary accessions: Q2VIP7 Q6NUS3 Q8NCT2

Explore the universe of human proteins at neXtProt for CDC14C: NX_A4D256

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A4D256

  • CDC14C Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0016021integral to membrane IEA--

    CDC14C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR026068 Dual_Pase_CDC14

    Graphical View of Domain Structure for InterPro Entry A4D256

    ProtoNet protein and cluster: A4D256

    UniProtKB/Swiss-Prot: CC14C_HUMAN, A4D256
    Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase
    (DSP) fold
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


    CDC14C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC14C_HUMAN, A4D256
    Function: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed
    kinases (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
         
    CDC14C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC14C:
     Stronger migration 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC14C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC14C (CC14C)

    Search CenterWatch for drugs/clinical trials and news about CDC14C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC14C gene: 
    NM_152627.1  

    Unigene Cluster for CDC14C:

    Cell division cycle 14C
    Hs.567757  [show with all ESTs]
    Unigene Representative Sequence: BC068452
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428251 ENST00000406468
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC14C

    Additional mRNA sequence: 

    BC028690.2 BC068452.1 NR_003595.1 

    3 DOTS entries:

    DT.102820247  DT.99951715  DT.454283 

    8 AceView cDNA sequences:

    BC028690 BV198672 BG723382 BC068452 BG722740 BG722222 BG718843 BI459566 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC14C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAATACC
    CDC14C Expression
    About this image


    Genevestigator expression for CDC14C

    SOURCE GeneReport for Unigene cluster: Hs.567757
        SABiosciences Custom PCR Arrays for CDC14C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for CDC14C (if available)
    TreeFam Gene Tree for CDC14C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC14C gene
    3 SIMAP similar genes for CDC14C using alignment to 1 protein entry:     CC14C_HUMAN:
    CDC14B    MGC26484    CDC14A

    CDC14C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 SNPs in CDC14C are shown (see all 151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074678341,2
    Cuntested148965460(+) CACAAA/GGTGAT 1 -- nc-transcript-variant0--------
    rs1509879551,2
    C--48962214(+) GAAGCA/GGCCAT 1 -- us2k10--------
    rs1495097931,2
    --48962253(+) AGTCTA/GTTCCT 1 -- us2k10--------
    rs1469431321,2
    C--48962263(+) TGTGGC/TTACCT 1 -- us2k10--------
    rs1857388731,2
    C--48962395(+) AAGATA/CTCTTG 1 -- us2k10--------
    rs1482101691,2
    --48962408(+) AAGCAA/GATGCC 1 -- us2k10--------
    rs2007340301,2
    C--48962446(+) TGAAA-/GGGTAG 1 -- us2k10--------
    rs2004845191,2
    C--48962524(+) TATTAC/TTTTTT 1 -- us2k10--------
    rs2016022171,2
    C--48962553(+) TCAGCC/TTACCT 1 -- us2k10--------
    rs2000687651,2
    C--48962621(+) GGACCC/GCAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC14C (48959361 - 48967049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDC14C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv888012CNV Gain21882294
    esv33916CNV Gain17666407
    nsv292OTHER Inversion15895083
    nsv7396OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDC14C for disorders           About MalaCards

    CDC14C for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDC14C

    Export disorders for CDC14C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC14C gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CDC14C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. (PubMed id 18547142)1, 3 Rosso L....Kaessmann H. (2008)
    2. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
    3. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    6. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)4 Gottlieb D.J....Wilk J.B. (2007)
    7. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 168448 HGNC: 22427 AceView: MGC26484 Ensembl:ENSG00000218305 euGenes: HUgn168448
    ECgene: CDC14C H-InvDB: CDC14C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC14C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC14C gene:
    Search GeneIP for patents involving CDC14C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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