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Aliases for CDC14C Gene

Aliases for CDC14C Gene

  • Cell Division Cycle 14C 2 3 5
  • CDC14 Cell Division Cycle 14 Homolog C 3 4
  • Cdc14B2 3 4
  • CDC14 Cell Division Cycle 14 Homolog C (S. Cerevisiae) 2
  • CDC14 Cell Division Cycle 14 C Pseudogene 3
  • CDC14Bretro 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for CDC14C Gene

Previous GeneCards Identifiers for CDC14C Gene

  • GC07P048737
  • GC07P048934
  • GC07P049007

Summaries for CDC14C Gene

GeneCards Summary for CDC14C Gene

CDC14C (Cell Division Cycle 14C) is a Pseudogene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for CDC14C Gene

  • Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC14C Gene

Genomics for CDC14C Gene

Regulatory Elements for CDC14C Gene

Enhancers for CDC14C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDC14C on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC14C Gene

Chromosome:
7
Start:
48,919,765 bp from pter
End:
48,927,453 bp from pter
Size:
7,689 bases
Orientation:
Plus strand

Genomic View for CDC14C Gene

Genes around CDC14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14C Gene

Proteins for CDC14C Gene

  • Protein details for CDC14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D256-CC14C_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14C
    Protein Accession:
    A4D256
    Secondary Accessions:
    • Q2VIP7
    • Q6NUS3
    • Q8NCT2

    Protein attributes for CDC14C Gene

    Size:
    554 amino acids
    Molecular mass:
    63299 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May act as an autosomal functional substitute.

neXtProt entry for CDC14C Gene

Proteomics data for CDC14C Gene at MOPED

Post-translational modifications for CDC14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDC14C Gene

Domains & Families for CDC14C Gene

Suggested Antigen Peptide Sequences for CDC14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D256

UniProtKB/Swiss-Prot:

CC14C_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14C: view

No data available for Gene Families for CDC14C Gene

Function for CDC14C Gene

Molecular function for CDC14C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

Enzyme Numbers (IUBMB) for CDC14C Gene

Gene Ontology (GO) - Molecular Function for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IBA --
genes like me logo Genes that share ontologies with CDC14C: view
genes like me logo Genes that share phenotypes with CDC14C: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDC14C Gene

Localization for CDC14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14C Gene

Membrane; Single-pass membrane protein. Nucleus, nucleolus. Note=Nucleolar during interphase. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CDC14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CDC14C: view

No data available for Subcellular locations from COMPARTMENTS for CDC14C Gene

Pathways & Interactions for CDC14C Gene

SuperPathways for CDC14C Gene

No Data Available

Interacting Proteins for CDC14C Gene

Gene Ontology (GO) - Biological Process for CDC14C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDC14C Gene

Drugs & Compounds for CDC14C Gene

(2) Additional Compounds for CDC14C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CDC14C: view

Transcripts for CDC14C Gene

mRNA/cDNA for CDC14C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDC14C Gene

Cell division cycle 14C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14C Gene

No ASD Table

Relevant External Links for CDC14C Gene

GeneLoc Exon Structure for
CDC14C
ECgene alternative splicing isoforms for
CDC14C

Expression for CDC14C Gene

mRNA expression in normal human tissues for CDC14C Gene

mRNA differential expression in normal tissues according to GTEx for CDC14C Gene

This gene is overexpressed in Testis (x18.5).

SOURCE GeneReport for Unigene cluster for CDC14C Gene Hs.567757

genes like me logo Genes that share expression patterns with CDC14C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDC14C Gene

Orthologs for CDC14C Gene

Evolution for CDC14C Gene

ENSEMBL:
Gene Tree for CDC14C (if available)
TreeFam:
Gene Tree for CDC14C (if available)

No data available for Orthologs for CDC14C Gene

Paralogs for CDC14C Gene

(3) SIMAP similar genes for CDC14C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDC14C: view

No data available for Paralogs for CDC14C Gene

Variants for CDC14C Gene

Sequence variations from dbSNP and Humsavar for CDC14C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1615556 - 48,925,063(-) ATAGG(A/G)TGTAT nc-transcript-variant
rs421206 - 48,925,237(-) TATTA(G/T)CCAAT nc-transcript-variant
rs6960408 -- 48,924,336(+) TATAG(A/C)CCTTC upstream-variant-2KB
rs6960441 -- 48,924,399(+) AGGCG(C/T)TGTGG upstream-variant-2KB
rs6960588 -- 48,924,431(+) CTGCA(C/G)CACCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDC14C Gene

Variant ID Type Subtype PubMed ID
nsv888012 CNV Gain 21882294
nsv7396 OTHER Inversion 18451855
nsv292 OTHER Inversion 15895083
esv33916 CNV Gain 17666407

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for CDC14C Gene

Disorders for CDC14C Gene

Relevant External Links for CDC14C

Genetic Association Database (GAD)
CDC14C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC14C

No disorders were found for CDC14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC14C Gene

Publications for CDC14C Gene

  1. Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. (PMID: 18547142) Rosso L. … Kaessmann H. (PLoS Biol. 2008) 2 3 67
  2. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  3. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDC14C Gene

Sources for CDC14C Gene

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