Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDC14B Gene

protein-coding   GIFtS: 60
GCID: GC09M099252

Cell Division Cycle 14B

(Previous names: CDC14 (cell division cycle 14, S. cerevisiae) homolog B,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cell Division Cycle 14B1 2     Cdc14B22
CDC14 Cell Division Cycle 14 Homolog B2 3     Dual Specificity Protein Phosphatase CDC14B2
CDC14 (Cell Division Cycle 14, S. Cerevisiae) Homolog B1     hCDC14B2
CDC14 Cell Division Cycle 14 Homolog B (S. Cerevisiae)1     EC 3.1.3.163
CDC14B32     EC 3.1.3.483
Cdc14B12     

External Ids:    HGNC: 17191   Entrez Gene: 85552   Ensembl: ENSG000000813777   OMIM: 6035055   UniProtKB: O607293   

Export aliases for CDC14B gene to outside databases

Previous GC identifers: GC09M090066 GC09M090996 GC09M092709 GC09M094632 GC09M096332 GC09M098292


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDC14B Gene:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This
protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit
of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein
has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the
function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDC14B Gene:
CDC14B (cell division cycle 14B) is a protein-coding gene. Diseases associated with CDC14B include hepatocellular carcinoma, and thyroiditis. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729
Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage
checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of
the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to
the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by
proline-directed kinases

Gene Wiki entry for CDC14B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC14B gene promoter:
         E2F-4   E2F-3a   AhR   Elk-1   AML1a   E2F-2   POU6F1 (c2)   Arnt   E2F-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDC14B promoter sequence
   Search Chromatin IP Primers for CDC14B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC14B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.3

CDC14B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099252:  view genomic region     (about GC identifiers)

Start:
99,252,523 bp from pter      End:
99,382,112 bp from pter
Size:
129,590 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14B  
Size: 498 amino acids; 56802 Da
Subunit: Interacts with FZR1/CDH1
Sequence caution: Sequence=CAI40539.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for CDC14B:
1OHC (3D)        1OHD (3D)        1OHE (3D)    
Secondary accessions: A6N5X8 A8MQ20 B1AL31 B1AL32 O43183 O60730 Q5JU08
Alternative splicing: 5 isoforms:  O60729-1   O60729-2   O60729-3   O60729-4   O60729-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC14B: NX_O60729

Explore proteomics data for CDC14B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC14B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070649.1  NP_003662.1  NP_201588.1  

    ENSEMBL proteins: 
     ENSP00000417897   ENSP00000413940   ENSP00000364389   ENSP00000364388   ENSP00000364390  
     ENSP00000420572   ENSP00000396951   ENSP00000400480   ENSP00000265659   ENSP00000364384  

    CDC14B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDC14B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDC14B
    GenScript Custom Purified and Recombinant Proteins Services for CDC14B
    Novus Biologicals CDC14B Proteins
    Novus Biologicals CDC14B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDC14B

    CDC14B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDC14B
    Novus Biologicals CDC14B Antibodies
    Abcam antibodies for CDC14B
    Cloud-Clone Corp. Antibodies for CDC14B
    ThermoFisher Antibodies for CDC14B
    LSBio Antibodies in human, mouse, rat for CDC14B

    CDC14B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDC14B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDC14B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDC14B
    Cloud-Clone Corp. CLIAs for CDC14B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DUSPC: Protein tyrosine phosphatases / Class I Cys-based PTPs : CDC14s

    5 InterPro protein domains:
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR026068 Dual_Pase_CDC14

    Graphical View of Domain Structure for InterPro Entry O60729

    ProtoNet protein and cluster: O60729

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729
    Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase
    (DSP) fold
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


    CDC14B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC14B_HUMAN, O60729
    Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage
    checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of
    the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to
    the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by
    proline-directed kinases
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity IDA18662541
    GO:0004725protein tyrosine phosphatase activity IDA9367992
    GO:0005515protein binding IPI12697818
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016791phosphatase activity ----
         
    CDC14B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC14B:
     Decreased focal adhesion (FA)  

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cdc14b):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  no phenotypic analysis 
     reproductive system  skeleton  vision/eye 

    CDC14B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdc14btm1.2Pzg for CDC14B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC14B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC14B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDC14B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDC14B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDC14B:
    hsa-mir-26b-5p (MIRT029462), hsa-mir-124-3p (MIRT002563), hsa-mir-15a-5p (MIRT000827), hsa-mir-16-5p (MIRT000826)

    Block miRNA regulation of human, mouse, rat CDC14B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC14B (see all 93):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-128 hsa-miR-3622b-3p hsa-miR-155* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDC14B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDC14B
    Predesigned siRNA for gene silencing in human, mouse, rat CDC14B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDC14B

    Clone
    Products:
         
    OriGene clones in human, mouse for CDC14B (see all 17)
    OriGene ORF clones in mouse, rat for CDC14B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC14B (NM_003671)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC14B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC14B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDC14B
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDC14B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CC14B_HUMAN, O60729: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the
    nucleolus to the nucleoplasm and interacts with FZR1/CDH1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9367992
    GO:0005654nucleoplasm IDA18662541
    GO:0005730nucleolus IDA18662541
    GO:0031965nuclear membrane IDA--

    CDC14B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CDC14B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2PLK1 signaling events
    PLK1 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CDC14B
        Cell cycle
    PLK1 signaling events


    1 Kegg Pathway  (Kegg details for CDC14B):
        Cell cycle


    CDC14B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC14B: 
              Protein Phosphatases in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDC14B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC14B (O607291, 2, 3 ENSP000003643894) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT2Q8IXJ61, 2, 3, ENSP000002493964EBI-970231,EBI-477232 MINT-8216391 MINT-8216381 I2D: score=2 STRING: ENSP00000249396
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    SKP2Q133093, ENSP000002742554I2D: score=1 STRING: ENSP00000274255
    FZR1Q9UM113, ENSP000003785294I2D: score=1 STRING: ENSP00000378529
    ANAPC1ENSP000003391094STRING: ENSP00000339109
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006470protein dephosphorylation NAS9367992
    GO:0016311dephosphorylation ----
    GO:0031572G2 DNA damage checkpoint IDA18662541
    GO:0035335peptidyl-tyrosine dephosphorylation IDA9367992

    CDC14B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC14B (CC14B)

    3 HMDB Compounds for CDC14B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDC14B gene (4 alternative transcripts): 
    NM_001077181.1  NM_003671.3  NM_033331.2  NM_033332.1  

    Unigene Cluster for CDC14B:

    Cell division cycle 14B
    Hs.40582  [show with all ESTs]
    Unigene Representative Sequence: NM_033331
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474602 ENST00000412285(uc004awi.3) ENST00000375241(uc004awj.3 uc004awk.3 uc004awl.3)
    ENST00000375240 ENST00000375242 ENST00000463569 ENST00000481149 ENST00000452280
    ENST00000415608 ENST00000480920 ENST00000496750 ENST00000463547 ENST00000484948
    ENST00000265659 ENST00000375236
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDC14B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC14B (see all 93):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-128 hsa-miR-3622b-3p hsa-miR-155* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDC14B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDC14B
    Predesigned siRNA for gene silencing in human, mouse, rat CDC14B
    Clone
    Products:
         
    OriGene clones in human, mouse for CDC14B (see all 17)
    OriGene ORF clones in mouse, rat for CDC14B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDC14B (NM_003671)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC14B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC14B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC14B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC14B
      QuantiTect SYBR Green Assays in human, mouse, rat CDC14B
      QuantiFast Probe-based Assays in human, mouse, rat CDC14B

    Additional mRNA sequence: 

    AF064104.1 AK024886.1 AK126388.1 AK225361.1 BC050013.1 EF611343.1 

    16 DOTS entries:

    DT.454283  DT.91840499  DT.100739533  DT.100017203  DT.40202717  DT.317227  DT.100812802  DT.121174362 
    DT.91743831  DT.91909711  DT.97790162  DT.102832313  DT.121174427  DT.75105618  DT.91813544  DT.92324051 

    Selected AceView cDNA sequences (see all 173):

    AW271614 AI200409 AA242742 AI220354 CB136222 BM671987 BG058500 BE501717 
    AI739548 AA417319 AA173406 Z39900 NM_033332 NM_033331 AK126388 R17649 
    BM127513 BX480818 BM772423 AW118831 BM722702 AF064104 AI368021 T35321 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDC14B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:        -     -     -     -         


    ECgene alternative splicing isoforms for CDC14B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDC14B expression in normal human tissues (normalized intensities)      CDC14B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTAAAAG
    CDC14B Expression
    About this image


    CDC14B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
    CDC14B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC14B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40582
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDC14B: 
              Protein Phosphatases in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDC14B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC14B
    QuantiTect SYBR Green Assays in human, mouse, rat CDC14B
    QuantiFast Probe-based Assays in human, mouse, rat CDC14B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC14B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc14b1 , 5 CDC14 cell division cycle 14 homolog B (S. cerevisiae)5
    CDC14 cell division cycle 14B1
    87.29(n)1
    86.7(a)1
      13 (33.26 cM)5
    2182941  NM_172587.31  NP_766175.31 
     641925455 
    chicken
    (Gallus gallus)
    Aves CDC14B1 CDC14 cell division cycle 14 homolog B (S. cerevisiae) 71.49(n)
    65.7(a)
      427473  XM_004949233.1  XP_004949290.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC14B6
    cell division cycle 14B
    64(a)
    1 ↔ 1
    2(39908241-39952754)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.193102 Transcribed sequence with moderate similarity to protein more 74.43(n)    AL874877.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdc14b6
    CDC14 cell division cycle 14 homolog B
    51(a)
    1 ↔ 1
    8(1290801-1335916) ENSDARG00000021483
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71343 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    59(a)   28C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-146
    Protein CDC-14, isoform b
    16(a)
    1 → many
    II(5587623-5593425) WBGene00000383
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC146
    Protein phosphatase required for mitotic exit; loc...
    21(a)
    1 → many
    VI(208413-210068) YFR028C


    ENSEMBL Gene Tree for CDC14B (if available)
    TreeFam Gene Tree for CDC14B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDC14B gene
    CDC14A2  DUSP232  
    4 SIMAP similar genes for CDC14B using alignment to 5 protein entries:     CC14B_HUMAN (see all proteins):
    CDC14C    MGC26484    CDC14A    DUSP23

    CDC14B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CDC14B
    PGOHUM00000250867 PGOHUM00000250932


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDC14B (see all 2165)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423608131,2
    --99262050(+) GTAAGA/CCCCAA 3 -- ds50010--------
    rs1130038571,2
    C,F--99262227(+) CTCCAG/CAACTG 3 -- ds50012Minor allele frequency- C:0.08CSA WA 120
    rs78714041,2
    C,F,A,H--99262296(+) tagaaA/Gactta 3 -- ds500121Minor allele frequency- G:0.26NS EA NA WA CSA 2227
    rs1878839281,2
    --99262466(+) AACCAA/GTTACA 3 -- ut310--------
    rs1895721831,2
    --99262504(+) ATGTAC/TCAAAC 3 -- ut310--------
    rs1822686261,2
    --99262559(+) TAAAAA/GTACCT 3 -- ut310--------
    rs109913821,2
    --99262759(+) ACTATC/GATCGG 3 -- ut31 ese30--------
    rs561673181,2
    C--99262788(+) TTCTA-/ACCAGG 3 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1880724021,2
    --99262924(+) AGCCTC/TTCCAG 3 -- ut310--------
    rs1927285121,2
    --99262971(+) TAAAAG/TAGGTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CDC14B (99252523 - 99382112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CDC14B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2306628CNV Deletion18987734
    esv2089533CNV Deletion18987734
    nsv522838CNV Loss19592680
    nsv415660CNV Loss16902084
    nsv893604CNV Gain21882294
    esv6348CNV Gain19470904
    nsv893605CNV Gain21882294
    nsv824999CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC14B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC14B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603505    OMIM disorders: --

    2 diseases for CDC14B:    About MalaCards
    hepatocellular carcinoma    thyroiditis


    CDC14B for disorders           About GeneDecksing


    Export disorders for CDC14B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDC14B gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CDC14B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)1, 2, 3 Li L.... Dixon J.E. (J. Biol. Chem. 1997)
    2. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)1, 2 Bassermann F.... Pagano M. (Cell 2008)
    3. The structure of the cell cycle protein Cdc14 reveals a proline- directed protein phosphatase. (PubMed id 12853468)1, 2 Gray C.H.... Barford D. (EMBO J. 2003)
    4. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)1, 2 Mailand N.... Lukas J. (Nat. Cell Biol. 2002)
    5. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)1, 2 Kaiser B.K.... Jackson P.K. (Mol. Biol. Cell 2002)
    6. The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. (PubMed id 15899858)1, 9 Cho H.P....Wang Y. (Mol. Cell. Biol. 2005)
    7. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. (PubMed id 18458157)1, 9 Wu J....Wang Y. (J. Cell Biol. 2008)
    8. Functional homology among human and fission yeast Cdc14 phosphatases. (PubMed id 15911625)1, 9 VA!zquez-Novelle M.D....SacristA!n M.P. (J. Biol. Chem. 2005)
    9. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. (PubMed id 10644693)1, 9 Li L....Dixon J.E. (J. Biol. Chem. 2000)
    10. Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression. (PubMed id 22784093)1 Ji M.... Dong J. (Biochem. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8555 HGNC: 1719 AceView: CDC14B Ensembl:ENSG00000081377 euGenes: HUgn8555
    ECgene: CDC14B Kegg: 8555 H-InvDB: CDC14B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDC14B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC14B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc14b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDC14B gene:
    Search GeneIP for patents involving CDC14B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CDC14B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDC14B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDC14B  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDC14B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDC14B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDC14B   OriGene Custom Protein Services for CDC14B  

     
     
     Block miRNA regulation of human, mouse, rat CDC14B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDC14B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC14B Predesigned siRNA for gene silencing in human, mouse, rat CDC14B
     QuantiFast Probe-based Assays in human, mouse, rat CDC14B QuantiTect SYBR Green Assays in human, mouse, rat CDC14B
     PCR Arrays including human, mouse, rat CDC14B Search Chromatin IP Primers for CDC14B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDC14B  Search GeneGlobe Interaction Network for CDC14B
     Regulatory tfbs in CDC14B promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDC14B GenScript cDNA clones with any tag delivered in your preferred vector for CDC14B
     GenScript Custom Assay Services for CDC14B GenScript Custom overexpressing Cell Line Services for CDC14B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDC14B (CC14B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDC14B antibodies
     CDC14B proteins
     CDC14B lysates
     Antibodies for CDC14B
     See all of Abcam's Antibodies, Kits and Proteins for CDC14B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CDC14B
     Antibodies for CDC14B
     ELISAs for CDC14B
     CLIAs for CDC14B



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDC14B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14B
     SwitchGear 3'UTR luciferase reporter plasmids for CDC14B
     SwitchGear Promoter luciferase reporter plasmids for CDC14B
     ThermoFisher Antibodies for CDC14B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDC14B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC14B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDC14B
     LSBio Antibodies in human, mouse, rat for CDC14B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDC14B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4