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Aliases for CDC14B Gene

Aliases for CDC14B Gene

  • Cell Division Cycle 14B 2 3 5
  • CDC14 Cell Division Cycle 14 Homolog B 3 4
  • CDC14 (Cell Division Cycle 14, S. Cerevisiae) Homolog B 2
  • CDC14 Cell Division Cycle 14 Homolog B (S. Cerevisiae) 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • CDC14B3 3
  • Cdc14B1 3
  • Cdc14B2 3
  • HCDC14B 3

External Ids for CDC14B Gene

Previous GeneCards Identifiers for CDC14B Gene

  • GC09M090066
  • GC09M090996
  • GC09M092709
  • GC09M094632
  • GC09M096332
  • GC09M098292
  • GC09M099252

Summaries for CDC14B Gene

Entrez Gene Summary for CDC14B Gene

  • The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC14B Gene

CDC14B (Cell Division Cycle 14B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Cell cycle. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot for CDC14B Gene

  • Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Gene Wiki entry for CDC14B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC14B Gene

Genomics for CDC14B Gene

Regulatory Elements for CDC14B Gene

Promoters for CDC14B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDC14B on UCSC Golden Path with GeneCards custom track

Genomic Location for CDC14B Gene

Chromosome:
9
Start:
96,490,218 bp from pter
End:
96,619,830 bp from pter
Size:
129,613 bases
Orientation:
Minus strand

Genomic View for CDC14B Gene

Genes around CDC14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14B Gene

Proteins for CDC14B Gene

  • Protein details for CDC14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60729-CC14B_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14B
    Protein Accession:
    O60729
    Secondary Accessions:
    • A6N5X8
    • A8MQ20
    • B1AL31
    • B1AL32
    • O43183
    • O60730
    • Q5JU08

    Protein attributes for CDC14B Gene

    Size:
    498 amino acids
    Molecular mass:
    56802 Da
    Quaternary structure:
    • Interacts with FZR1/CDH1.
    SequenceCaution:
    • Sequence=CAI40539.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDC14B Gene

    Alternative splice isoforms for CDC14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC14B Gene

Proteomics data for CDC14B Gene at MOPED

Post-translational modifications for CDC14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDC14B Gene

Domains & Families for CDC14B Gene

Gene Families for CDC14B Gene

Graphical View of Domain Structure for InterPro Entry

O60729

UniProtKB/Swiss-Prot:

CC14B_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14B: view

Function for CDC14B Gene

Molecular function for CDC14B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Enzyme Numbers (IUBMB) for CDC14B Gene

Gene Ontology (GO) - Molecular Function for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA,IDA 9367992
GO:0005515 protein binding IPI 12697818
genes like me logo Genes that share ontologies with CDC14B: view
genes like me logo Genes that share phenotypes with CDC14B: view

Animal Models for CDC14B Gene

MGI Knock Outs for CDC14B:

Animal Model Products

miRNA for CDC14B Gene

miRTarBase miRNAs that target CDC14B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC14B Gene

Localization for CDC14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14B Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC14B Gene COMPARTMENTS Subcellular localization image for CDC14B gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CDC14B: view

Pathways & Interactions for CDC14B Gene

genes like me logo Genes that share pathways with CDC14B: view

Pathways by source for CDC14B Gene

2 BioSystems pathways for CDC14B Gene
1 KEGG pathway for CDC14B Gene

SIGNOR curated interactions for CDC14B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for CDC14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,NAS 9367992
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with CDC14B: view

Drugs & Compounds for CDC14B Gene

(1) Drugs for CDC14B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for CDC14B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CDC14B: view

Transcripts for CDC14B Gene

Unigene Clusters for CDC14B Gene

Cell division cycle 14B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: - - - -

Relevant External Links for CDC14B Gene

GeneLoc Exon Structure for
CDC14B
ECgene alternative splicing isoforms for
CDC14B

Expression for CDC14B Gene

mRNA expression in normal human tissues for CDC14B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDC14B Gene



SOURCE GeneReport for Unigene cluster for CDC14B Gene Hs.40582

genes like me logo Genes that share expression patterns with CDC14B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDC14B Gene

Orthologs for CDC14B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC14B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC14B 35
  • 91.9 (n)
  • 89.76 (a)
CDC14B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC14B 35
  • 92.44 (n)
  • 91.16 (a)
CDC14B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc14b 35
  • 87.29 (n)
  • 86.7 (a)
Cdc14b 16
Cdc14b 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC14B 35
  • 99.63 (n)
  • 99.78 (a)
CDC14B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc14b 35
  • 88.15 (n)
  • 88.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDC14B 35
  • 71.49 (n)
  • 65.7 (a)
CDC14B 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC14B 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc14b 35
  • 68.31 (n)
  • 64.93 (a)
Str.19310 35
zebrafish
(Danio rerio)
Actinopterygii cdc14b 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7134 37
  • 59 (a)
cdc14 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-14 36
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 36
  • 21 (a)
OneToMany
Species with no ortholog for CDC14B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC14B Gene

ENSEMBL:
Gene Tree for CDC14B (if available)
TreeFam:
Gene Tree for CDC14B (if available)

Paralogs for CDC14B Gene

Paralogs for CDC14B Gene

(4) SIMAP similar genes for CDC14B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CDC14B Gene

genes like me logo Genes that share paralogs with CDC14B: view

Variants for CDC14B Gene

Sequence variations from dbSNP and Humsavar for CDC14B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16911114 - 96,533,968(-) AGATA(C/T)CTGTG nc-transcript-variant, reference, missense
rs16911075 - 96,523,650(-) GACCA(C/T)TGCGT nc-transcript-variant, reference, missense
rs1005094 -- 96,497,580(+) GCTAT(C/T)AACTG intron-variant
rs1411885 -- 96,562,095(+) CAAAG(C/T)ACATT intron-variant, reference, synonymous-codon
rs2026929 -- 96,551,611(+) TACGA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC14B Gene

Variant ID Type Subtype PubMed ID
nsv893604 CNV Gain 21882294
nsv522838 CNV Loss 19592680
esv2306628 CNV Deletion 18987734
esv2089533 CNV Deletion 18987734
esv6348 CNV Gain 19470904
nsv415660 CNV Loss 16902084
nsv893605 CNV Gain 21882294
nsv824999 CNV Gain 20364138

Variation tolerance for CDC14B Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC14B Gene

HapMap Linkage Disequilibrium report
CDC14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC14B Gene

Disorders for CDC14B Gene

Relevant External Links for CDC14B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC14B

No disorders were found for CDC14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC14B Gene

Publications for CDC14B Gene

  1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PMID: 9367992) Li L. … Dixon J.E. (J. Biol. Chem. 1997) 2 3 4 67
  2. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. (PMID: 18458157) Wu J. … Wang Y. (J. Cell Biol. 2008) 3 23
  3. The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. (PMID: 15899858) Cho H.P. … Wang Y. (Mol. Cell. Biol. 2005) 3 23
  4. Functional homology among human and fission yeast Cdc14 phosphatases. (PMID: 15911625) VA!zquez-Novelle M.D. … SacristA!n M.P. (J. Biol. Chem. 2005) 3 23
  5. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. (PMID: 10644693) Li L. … Dixon J.E. (J. Biol. Chem. 2000) 3 23

Products for CDC14B Gene

Sources for CDC14B Gene

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