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Aliases for CDC14A Gene

Aliases for CDC14A Gene

  • Cell Division Cycle 14A 2 3 5
  • CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog) 2 3
  • CDC14 Cell Division Cycle 14 Homolog A 3 4
  • CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae) 2
  • Dual Specificity Protein Phosphatase CDC14A 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DFNB105 3
  • HCDC14 3
  • Cdc14 3

External Ids for CDC14A Gene

Previous GeneCards Identifiers for CDC14A Gene

  • GC01P101608
  • GC01P099999
  • GC01P100108
  • GC01P100280
  • GC01P100530
  • GC01P100590
  • GC01P100817
  • GC01P098941

Summaries for CDC14A Gene

Entrez Gene Summary for CDC14A Gene

  • The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDC14A Gene

CDC14A (Cell Division Cycle 14A) is a Protein Coding gene. Diseases associated with CDC14A include Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Signaling by GPCR and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CDC14B.

UniProtKB/Swiss-Prot for CDC14A Gene

  • Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.

Gene Wiki entry for CDC14A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC14A Gene

Genomics for CDC14A Gene

Regulatory Elements for CDC14A Gene

Enhancers for CDC14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CDC14A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDC14A gene promoter:

Genomic Location for CDC14A Gene

Chromosome:
1
Start:
100,345,025 bp from pter
End:
100,520,277 bp from pter
Size:
175,253 bases
Orientation:
Plus strand

Genomic View for CDC14A Gene

Genes around CDC14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC14A Gene

Proteins for CDC14A Gene

  • Protein details for CDC14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH5-CC14A_HUMAN
    Recommended name:
    Dual specificity protein phosphatase CDC14A
    Protein Accession:
    Q9UNH5
    Secondary Accessions:
    • A6MA65
    • B1AQ14
    • B1AQ15
    • O43171
    • O60727
    • O60728
    • Q52LH9
    • Q8IXX0

    Protein attributes for CDC14A Gene

    Size:
    594 amino acids
    Molecular mass:
    66574 Da
    Quaternary structure:
    • Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
    SequenceCaution:
    • Sequence=AAB88277.1; Type=Frameshift; Positions=6; Evidence={ECO:0000305};

    Alternative splice isoforms for CDC14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDC14A Gene

Post-translational modifications for CDC14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDC14A Gene

Domains & Families for CDC14A Gene

Gene Families for CDC14A Gene

Suggested Antigen Peptide Sequences for CDC14A Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNH5

UniProtKB/Swiss-Prot:

CC14A_HUMAN :
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Domain:
  • Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
genes like me logo Genes that share domains with CDC14A: view

Function for CDC14A Gene

Molecular function for CDC14A Gene

GENATLAS Biochemistry:
cell division cycle 14A,dual specificity serine/threonine-tyrosine phosphatase,involved in cell cycle function and in tumorigenesis,with homology to PTEN
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.

Enzyme Numbers (IUBMB) for CDC14A Gene

Gene Ontology (GO) - Molecular Function for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 9367992
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity IBA --
GO:0005515 protein binding IPI 16221885
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with CDC14A: view
genes like me logo Genes that share phenotypes with CDC14A: view

Animal Model Products

CRISPR Products

miRNA for CDC14A Gene

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC14A Gene

Localization for CDC14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC14A Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC14A Gene COMPARTMENTS Subcellular localization image for CDC14A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA --
GO:0005634 nucleus TAS 9367992
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CDC14A: view

Pathways & Interactions for CDC14A Gene

genes like me logo Genes that share pathways with CDC14A: view

Pathways by source for CDC14A Gene

1 KEGG pathway for CDC14A Gene
1 GeneGo (Thomson Reuters) pathway for CDC14A Gene

SIGNOR curated interactions for CDC14A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CDC14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007096 regulation of exit from mitosis IBA --
GO:0008283 cell proliferation TAS 9367992
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0042384 cilium assembly IBA --
GO:0051256 mitotic spindle midzone assembly IBA --
genes like me logo Genes that share ontologies with CDC14A: view

Drugs & Compounds for CDC14A Gene

(3) Drugs for CDC14A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for CDC14A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with CDC14A: view

Transcripts for CDC14A Gene

Unigene Clusters for CDC14A Gene

Cell division cycle 14A:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC14A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: -
SP7:

Relevant External Links for CDC14A Gene

GeneLoc Exon Structure for
CDC14A
ECgene alternative splicing isoforms for
CDC14A

Expression for CDC14A Gene

mRNA expression in normal human tissues for CDC14A Gene

mRNA differential expression in normal tissues according to GTEx for CDC14A Gene

This gene is overexpressed in Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of CDC14A Gene:

CDC14A

SOURCE GeneReport for Unigene cluster for CDC14A Gene:

Hs.127411
genes like me logo Genes that share expression patterns with CDC14A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CDC14A Gene

Orthologs for CDC14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDC14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC14A 34
  • 90.9 (n)
  • 93.42 (a)
CDC14A 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC14A 34
  • 92.62 (n)
  • 93.1 (a)
CDC14A 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc14a 34
  • 87.01 (n)
  • 88.21 (a)
Cdc14a 16
Cdc14a 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC14A 34
  • 99.38 (n)
  • 99.32 (a)
CDC14A 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc14a 34
  • 87.57 (n)
  • 88.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC14A 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC14A 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC14A 34
  • 73.29 (n)
  • 72.88 (a)
CDC14A 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC14A 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc14a 34
  • 66.25 (n)
  • 68.21 (a)
zebrafish
(Danio rerio)
Actinopterygii cdc14ab 34
  • 67.97 (n)
  • 74.13 (a)
zgc63654 34
cdc14aa 35
  • 56 (a)
OneToMany
cdc14ab 35
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4997 34
fruit fly
(Drosophila melanogaster)
Insecta CG7134 36
  • 63 (a)
cdc14 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-14 34
  • 48.15 (n)
  • 39.62 (a)
cdc-14 35
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 35
  • 22 (a)
OneToMany
CDC14 37
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1797 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8008 35
  • 51 (a)
OneToOne
Species where no ortholog for CDC14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDC14A Gene

ENSEMBL:
Gene Tree for CDC14A (if available)
TreeFam:
Gene Tree for CDC14A (if available)

Paralogs for CDC14A Gene

Paralogs for CDC14A Gene

(4) SIMAP similar genes for CDC14A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDC14A: view

Variants for CDC14A Gene

Sequence variations from dbSNP and Humsavar for CDC14A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28364897 - 100,484,348(+) AAATC(A/G)ACCAT reference, missense
rs28364923 - 100,518,261(+) TCAGT(C/G/T)TGAAT reference, missense, utr-variant-3-prime
VAR_035655 A colorectal cancer sample
rs494571 -- 100,369,990(+) aaaaa(A/T)ttttt intron-variant
rs502955 -- 100,353,138(-) GAGAG(C/T)CCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC14A Gene

Variant ID Type Subtype PubMed ID
esv3373317 CNV insertion 20981092
nsv1133882 CNV deletion 24896259
nsv473052 CNV novel sequence insertion 20440878
nsv546889 CNV gain 21841781
nsv830815 CNV gain 17160897
nsv830826 CNV gain 17160897
nsv950522 CNV duplication 24416366

Variation tolerance for CDC14A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC14A Gene

Disorders for CDC14A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDC14A Gene - From: Orphanet

Disorder Aliases PubMed IDs
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDC14A

Genetic Association Database (GAD)
CDC14A
Human Genome Epidemiology (HuGE) Navigator
CDC14A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC14A
genes like me logo Genes that share disorders with CDC14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDC14A Gene

Publications for CDC14A Gene

  1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PMID: 9367992) Li L. … Dixon J.E. (J. Biol. Chem. 1997) 2 3 4 22 65
  2. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. (PMID: 10409437) Wong A.K.C. … Teng D.H.-F. (Genomics 1999) 2 3 4 65
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PMID: 20477815) Song S.Y. … Lee S.H. (APMIS 2010) 3 46 65

Products for CDC14A Gene

Sources for CDC14A Gene

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