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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC14A Gene

protein-coding   GIFtS: 66
GCID: GC01P100817

cell division cycle 14A

(Previous names: CDC10 (cell division cycle 10, S. cerevisiae, homolog),...)
 Explore 6 diseases affiliated with
CDC14A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDC14A    

Aliases
for CDC14A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle 14A1 2     CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae)1
CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog)1 2     Dual Specificity Protein Phosphatase CDC14A2
Cdc141     HCDC141
CDC14 Cell Division Cycle 14 Homolog A2 3     EC 3.1.3.163
Cdc14A11     EC 3.1.3.483
Cdc14A21     

External Ids:    HGNC: 17181   Entrez Gene: 85562   Ensembl: ENSG000000793357   OMIM: 6035045   UniProtKB: Q9UNH53   

Export aliases for CDC14A gene to outside databases

Previous GC identifers: GC01P101608 GC01P099999 GC01P100108 GC01P100280 GC01P100530 GC01P100590 GC01P098941


Summaries
for CDC14A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDC14A:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly
similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and
initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with,
and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing
of this gene results in several transcript variants encoding distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic
cyclins and subsequent exit from mitosis

Gene Wiki entry for CDC14A


Genomic Views
for CDC14A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC14A gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC14A promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC14A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21

CDC14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P100817:  view genomic region     (about GC identifiers)

Start:
 100,810,584 bp from pter      End:
 100,985,833 bp from pter
Size:
 175,250 bases      Orientation:
 plus strand

Proteins
for CDC14A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14A  
Size: 594 amino acids; 66574 Da
Subunit: Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal
during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the
mitotic spindle
Sequence caution: Sequence=AAB88277.1; Type=Frameshift; Positions=6;
Secondary accessions: B1AQ14 B1AQ15 O43171 O60727 O60728 Q52LH9 Q8IXX0
Alternative splicing: 4 isoforms:  Q9UNH5-1   Q9UNH5-2   Q9UNH5-3   Q9UNH5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC14A: NX_Q9UNH5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNH5

    • CDC14A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_003663.2  NP_201569.1  NP_201570.1  

    ENSEMBL proteins: 
     ENSP00000388501   ENSP00000354916   ENSP00000359142   ENSP00000336739   ENSP00000442543  
     ENSP00000359143   ENSP00000442640  
    Reactome Protein details: Q9UNH5
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--


    CDC14A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDC14A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDC14A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR026068 Dual_Pase_CDC14

    Graphical View of Domain Structure for InterPro Entry Q9UNH5

    ProtoNet protein and cluster: Q9UNH5

    1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
    Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP)
    fold (By similarity)
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


    Function
    for CDC14A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
    Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
    division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic
    cyclins and subsequent exit from mitosis
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for CDC14A:
    cell division cycle 14A,dual specificity serine/threonine-tyrosine phosphatase,involved in cell cycle function and in
    tumorigenesis,with homology to PTEN

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDC14A
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC14A (see all 22):
    hsa-miR-124* hsa-miR-411* hsa-miR-379* hsa-miR-148b hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: CDC14A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CDC14A
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9367992
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI16221885
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--


    CDC14A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CDC14A:
     Decreased focal adhesion (FA)  


    Pathways & Interactions
    for CDC14A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    2Cell cycle Role of APC in cell cycle regulation
    		Cell cycle Role of APC in cell cycle regulation1.00
    		Cell cycle_Role of APC in cell cycle regulation0.98
    3Cell cycle
    		Cell cycle1.00
    		Cell cycle0.57
    4Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of mitotic cell cycle0.58
    		APC/C-mediated degradation of cell cycle proteins0.58
    5APC-Cdc20 mediated degradation of Nek2A
    		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CDC14A
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CDC14A
        Cell cycle Role of APC in cell cycle regulation

    1 BioSystems Pathway for CDC14A 
        Cell cycle

    5        Reactome Pathways for CDC14A
        APC/C-mediated degradation of cell cycle proteins
    Cell Cycle
    Regulation of mitotic cell cycle
    Cell Cycle, Mitotic
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase


    1         Kegg Pathway  (Kegg details for CDC14A):
        Cell cycle


    CDC14A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC14A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/155 Interacting proteins for CDC14A (Q9UNH53 ENSP000003549164) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation TAS9367992
    GO:0051301cell division IEA--


    CDC14A for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDC14A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC14A

    3 HMDB Compounds for CDC14A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about CDC14A / CC14A 

    Transcripts
    for CDC14A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDC14A gene (3 alternative transcripts): 
    NM_003672.3  NM_033312.2  NM_033313.2  

    Unigene Cluster for CDC14A:

    CDC14 cell division cycle 14 homolog A (S. cerevisiae)
    Hs.127411  [show with all ESTs]
    Unigene Representative Sequence: BC071578
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455467 ENST00000361544(uc001dtf.2 uc009wed.1) ENST00000370124(uc001dte.4)
    ENST00000336454 ENST00000469387 ENST00000544534 ENST00000370125(uc009wec.1 uc001dtg.4 uc009wee.3)
    ENST00000542213(uc009web.2 uc010oui.1)

    miRNA
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    hsa-miR-124* hsa-miR-411* hsa-miR-379* hsa-miR-148b hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: CDC14A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDC14A (see all 7)
    OriGene shRNA RFP: CDC14A
    OriGene siRNA: CDC14A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDC14A
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209857.1 AF000367.1 AF064102.1 AF064103.1 AF122013.1 AK302310.1 AK310292.1 AK310657.1 
    BC038979.1 BC071578.1 BC093916.1 BC093918.1 DQ530256.1 

    9 DOTS entries:

    DT.451645  DT.99960713  DT.87015169  DT.97800886  DT.121400440  DT.99971903  DT.121400435  DT.121400450 
    DT.40126932 

    24/59 AceView cDNA sequences (see all 59):

    Z40824 F12387 AI275415 BU631580 AA283949 BE138724 BG288564 AA442512 
    BI831763 AF122013 F10004 AF064102 AW148548 AI424661 BC071578 BC038979 
    CB156695 AF000367 BX476670 AI039326 AW008014 AI864242 CA439354 BP339585 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDC14A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                            -                                                           -                             -     -               
    SP2:                                            -                                                           -                                                   
    SP3:                                            -                       -                                   -                                                   
    SP4:                                            -                                                                                                               
    SP5:        -     -     -                       -                                                                                                               


    ECgene alternative splicing isoforms for CDC14A

    Expression
    for CDC14A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC14A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDC14A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPodocytesKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDC14A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC14A

    SOURCE GeneReport for Unigene cluster: Hs.127411
        SABiosciences Expression via Pathway-Focused PCR Array including CDC14A: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CDC14A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDC14A gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDC14A1 CDC14 cell division cycle 14 homolog A (S. cerevisiae) 73.93(n)
    73.46(a)    		   424466  NM_001177736.1  NP_001171207.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDC14A6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 4(87534617-87603068)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA987721.12   -- 78.24(n)    CA987721.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc636542 similar to CDC14 cell division cycle 14 homolog A (S. more 75.41(n)   394124  BC055188.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG71343 protein amino acid dephosphorylation protein
    tyrosine/serine/threonine more    		 63(a)   28C4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cdc-141 Protein CDC-14 47.38(n)
    39.55(a)    		   173945  NM_062684.4  NP_495085.2 


    ENSEMBL Gene Tree for CDC14A (if available)
    TreeFam Gene Tree for CDC14A (if available) 

    Paralogs
    for CDC14A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC14A gene
    DUSP232  CDC14B2  
    4 SIMAP similar genes for CDC14A using alignment to 4 protein entries:     CC14A_HUMAN (see all proteins):
    MGC26484    CDC14B    CDC14C    DUSP23

    CDC14A for paralogs           About GeneDecksing



    Genomic Variants
    for CDC14A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2676 NCBI SNPs in CDC14A are shown (see all 2676)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1464781271,2
    		C,--100816142(+) ATAAC-/AAGAAGGT 3 -- us2k10--------
    rs570725651,2
    		C,--100816283(+) AATTGT/CTGGGG 3 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1882627601,2
    		--100816339(+) AAATAC/TAACAA 3 -- us2k10--------
    rs37541301,2
    		C,--100816459(+) ATAAAA/GTAATT 3 -- us2k14Minor allele frequency- G:0.13WA CSA EA 241
    rs787046311,2
    		F,--100816471(+) GAGGCC/TTGGCG 3 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1810132951,2
    		--100816607(+) TAGCCA/GGGTGT 3 -- us2k10--------
    rs1446614431,2
    		--100817080(+) TTTAG-/CGGGAC 3 -- us2k10--------
    rs171223031,2
    		C,F,H,--100817103(+) CGCTTC/TAGCTG 3 -- us2k119Minor allele frequency- T:0.18NA NS EA WA 1870
    rs1416869501,2
    		--100817120(+) TGTAAA/GGAAAT 3 -- us2k10--------
    rs1450340441,2
    		C,--100817166(+) CTCTC-/CTCTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC14A (100810584 - 100985833 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDC14A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDC14A
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC14A

    Disorders / Diseases
    for CDC14A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDC14A for disorders           About GeneDecksing

    OMIM gene information: 603504    OMIM disorders: --

    6 diseases for CDC14A:    About MalaCards
    cartilage-hair hypoplasia    intrahepatic cholangiocarcinoma    cholangiocarcinoma    colon carcinoma
    breast cancer    carcinoma

    1 disease from the University of Copenhagen DISEASES database for CDC14A:
    cartilage-hair hypoplasia
    Human Genome Epidemiology (HuGE) Navigator: CDC14A (3 documents)

    Export disorders for CDC14A gene to outside databases

    Publications
    for CDC14A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC14A gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with CDC14A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)1, 2, 3, 9 Li L.... Dixon J.E. (1997)
    2. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. (PubMed id 10409437)1, 2, 3 Wong A.K....Teng D.H. (1999)
    3. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. (PubMed id 15263015)1, 2 Gruneberg U.... Barr F.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)1, 2 Kaiser B.K.... Jackson P.K. (2002)
    6. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)1, 2 Mailand N.... Lukas J. (2002)
    7. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. (PubMed id 11598127)1, 2 Bembenek J. and Yu H. (2001)
    8. Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320. (PubMed id 17172867)1, 9 Esteban V....Sacristan M.P. (2006)
    9. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. (PubMed id 10644693)1, 9 Li L....Dixon J.E. (2000)
    10. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. (PubMed id 20479464)1, 9 Mocciaro A....Schiebel E. (2010)

    External Searches for CDC14A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDC14A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8556 HGNC: 1718 AceView: CDC14A Ensembl:ENSG00000079335 euGenes: HUgn8556
    ECgene: CDC14A Kegg: 8556 H-InvDB: CDC14A

    Other Databases showing CDC14A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDC14A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC14A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC14A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc14a/

    Intellectual Property
    for CDC14A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDC14A gene:
    Search GeneIP for patents involving CDC14A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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