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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDC14A Gene

protein-coding   GIFtS: 67
GCID: GC01P100817

Cell Division Cycle 14A

(Previous names: CDC10 (cell division cycle 10, S. cerevisiae, homolog),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle 14A1 2     Dual Specificity Protein Phosphatase CDC14A2
CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog)1 2     hCDC142
CDC14 Cell Division Cycle 14 Homolog A2 3     EC 3.1.3.163
CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae)1     EC 3.1.3.483
cdc142     

External Ids:    HGNC: 17181   Entrez Gene: 85562   Ensembl: ENSG000000793357   OMIM: 6035045   UniProtKB: Q9UNH53   

Export aliases for CDC14A gene to outside databases

Previous GC identifers: GC01P101608 GC01P099999 GC01P100108 GC01P100280 GC01P100530 GC01P100590 GC01P098941


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC14A Gene:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is
highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell
mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown
to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of
p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDC14A Gene: 
CDC14A (cell division cycle 14A) is a protein-coding gene. Diseases associated with CDC14A include cartilage-hair hypoplasia, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Cell cycle and Regulation of APC/C activators between G1/S and early anaphase. GO annotations related to this gene include protein tyrosine phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP23.

UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of
mitotic cyclins and subsequent exit from mitosis

Gene Wiki entry for CDC14A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC14A gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC14A promoter sequence
   Search SABiosciences Chromatin IP Primers for CDC14A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDC14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21

CDC14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P100817:  view genomic region     (about GC identifiers)

Start:
100,810,584 bp from pter      End:
100,985,833 bp from pter
Size:
175,250 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14A  
Size: 594 amino acids; 66574 Da
Subunit: Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis.
Subsequently localizes to the midzone of the mitotic spindle
Sequence caution: Sequence=AAB88277.1; Type=Frameshift; Positions=6;
Secondary accessions: A6MA65 B1AQ14 B1AQ15 O43171 O60727 O60728 Q52LH9 Q8IXX0
Alternative splicing: 5 isoforms:  Q9UNH5-1   Q9UNH5-2   Q9UNH5-3   Q9UNH5-4   Q9UNH5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC14A: NX_Q9UNH5

Explore proteomics data for CDC14A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNH5

  • CDC14A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDC14A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_003663.2  NP_201569.1  NP_201570.1  

    ENSEMBL proteins: 
     ENSP00000388501   ENSP00000354916   ENSP00000359142   ENSP00000336739   ENSP00000442543  
     ENSP00000359143   ENSP00000442640  
    Reactome Protein details: Q9UNH5
    Human Recombinant Protein Products for CDC14A: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--

    CDC14A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPC: Protein tyrosine phosphatases / Class I Cys-based PTPs : CDC14s

    5 InterPro protein domains:
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR026068 Dual_Pase_CDC14

    Graphical View of Domain Structure for InterPro Entry Q9UNH5

    ProtoNet protein and cluster: Q9UNH5

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
    Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase
    (DSP) fold (By similarity)
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


    CDC14A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC14A_HUMAN, Q9UNH5
    Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
    division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of
    mitotic cyclins and subsequent exit from mitosis
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for CDC14A:
    cell division cycle 14A,dual specificity serine/threonine-tyrosine phosphatase,involved in cell cycle function and
    in tumorigenesis,with homology to PTEN

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9367992
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI16221885
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016791phosphatase activity ----
         
    CDC14A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC14A:
     Decreased focal adhesion (FA)  

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CDC14A:
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC14A (see all 22):
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    SwitchGear 3'UTR luciferase reporter plasmidCDC14A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDC14A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Regulation of mitotic cell cycle0.94
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    5Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CDC14A
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CDC14A
        Cell cycle Role of APC in cell cycle regulation

    1 BioSystems Pathway for CDC14A
        Cell cycle

    5        Reactome Pathways for CDC14A
        APC/C-mediated degradation of cell cycle proteins
    Cell Cycle
    Regulation of mitotic cell cycle
    Cell Cycle, Mitotic
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase


    1         Kegg Pathway  (Kegg details for CDC14A):
        Cell cycle


    CDC14A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDC14A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/161 Interacting proteins for CDC14A (Q9UNH53 ENSP000003549164) via UniProtKB, MINT, STRING, and/or I2D (see all 161)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation TAS9367992
    GO:0016311dephosphorylation ----
    GO:0051301cell division IEA--

    CDC14A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDC14A (CC14A)

    3 HMDB Compounds for CDC14A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about CDC14A / CC14A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDC14A gene (3 alternative transcripts): 
    NM_003672.3  NM_033312.2  NM_033313.2  

    Unigene Cluster for CDC14A:

    Cell division cycle 14A
    Hs.127411  [show with all ESTs]
    Unigene Representative Sequence: BC071578
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455467 ENST00000361544(uc001dtf.2 uc009wed.1) ENST00000370124(uc001dte.4)
    ENST00000336454 ENST00000469387 ENST00000544534 ENST00000370125(uc009wec.1 uc001dtg.4 uc009wee.3)
    ENST00000542213(uc009web.2 uc010oui.1)
    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CDC14A (see all 22):
    hsa-miR-124* hsa-miR-411* hsa-miR-379* hsa-miR-148b hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidCDC14A 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDC14A

    Additional mRNA sequence: 

    AB209857.1 AF000367.1 AF064102.1 AF064103.1 AF122013.1 AK302310.1 AK310292.1 AK310657.1 
    BC038979.1 BC071578.1 BC093916.1 BC093918.1 DQ530256.1 

    9 DOTS entries:

    DT.451645  DT.99960713  DT.87015169  DT.97800886  DT.121400440  DT.99971903  DT.121400435  DT.121400450 
    DT.40126932 

    24/59 AceView cDNA sequences (see all 59):

    BI831763 AI275415 BG288564 BU631580 F10004 AF122013 AA283949 AA442512 
    F12387 Z40824 BE138724 AI912735 CD356502 AA724124 NM_003672 AI028254 
    CA425188 AF064102 AI093163 BU609013 BC071578 NM_033312 AI864242 BC038979 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDC14A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                            -                                                           -                             -     -               
    SP2:                                            -                                                           -                                                   
    SP3:                                            -                       -                                   -                                                   
    SP4:                                            -                                                                                                               
    SP5:        -     -     -                       -                                                                                                               


    ECgene alternative splicing isoforms for CDC14A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDC14A expression in normal human tissues (normalized intensities)      CDC14A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTGTTA
    CDC14A Expression
    About this image


    CDC14A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/43 selected tissues (see all 43) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             brain/hindbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Cord Blood Pan-T Cells   
             cd4+ t cell   

    See CDC14A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDC14A

    SOURCE GeneReport for Unigene cluster: Hs.127411
        SABiosciences Expression via Pathway-Focused PCR Array including CDC14A: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC14A gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc14a1 , 5 CDC14 cell division cycle 14 homolog A (S. cerevisiae)5
    CDC14 cell division cycle 14A1
    87.01(n)1
    88.21(a)1
      3 (50.24 cM)5
    2297761  NM_001080818.21  NP_001074287.11 
     1162725535 
    chicken
    (Gallus gallus)
    Aves CDC14A1 CDC14 cell division cycle 14 homolog A (S. cerevisiae) 73.93(n)
    73.46(a)
      424466  NM_001177736.1  NP_001171207.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC14A6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    4(87534617-87603068)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA987721.12   -- 78.24(n)    CA987721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636542 similar to CDC14 cell division cycle 14 homolog A (S. more 75.41(n)   394124  BC055188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71343 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    63(a)   28C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-141 Protein CDC-14 47.38(n)
    39.55(a)
      173945  NM_062684.4  NP_495085.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC14(YFR028C)4 Protein phosphatase required for mitotic exit; located more   --   6(210068-208413) 850585  NP_116684.1 


    ENSEMBL Gene Tree for CDC14A (if available)
    TreeFam Gene Tree for CDC14A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDC14A gene
    DUSP232  CDC14B2  
    4 SIMAP similar genes for CDC14A using alignment to 3 protein entries:     CC14A_HUMAN (see all proteins):
    MGC26484    CDC14B    CDC14C    DUSP23

    CDC14A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3274 SNPs in CDC14A are shown (see all 3274)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356554
    A colorectal cancer sample4--see VAR_0356552 D Y mis40--------
    rs1464781271,2
    C--100816142(+) ATAAC-/AAGAAGGT 3 -- us2k10--------
    rs570725651,2
    C,F--100816283(+) AATTGT/CTGGGG 3 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1882627601,2
    --100816339(+) AAATAC/TAACAA 3 -- us2k10--------
    rs37541301,2
    C--100816459(+) ATAAAA/GTAATT 3 -- us2k14Minor allele frequency- G:0.13WA CSA EA 241
    rs787046311,2
    F--100816471(+) GAGGCC/TTGGCG 3 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1810132951,2
    --100816607(+) TAGCCA/GGGTGT 3 -- us2k10--------
    rs1132847691,2
    C--100816765(+) ACATT-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs793686781,2
    C--100817005(+) ACAGCC/TTTAGG 3 -- us2k10--------
    rs1446614431,2
    C--100817080(+) TTTAG-/CGGGAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC14A (100810584 - 100985833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDC14A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272458CNV Insertion20981092
    nsv830815CNV Gain17160897
    nsv830826CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603504    OMIM disorders: --

    4 diseases for CDC14A:    About MalaCards
    cartilage-hair hypoplasia    intrahepatic cholangiocarcinoma    cholangiocarcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CDC14A:
    cartilage-hair hypoplasia

    CDC14A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDC14A
    Human Genome Epidemiology (HuGE) Navigator: CDC14A (3 documents)

    Export disorders for CDC14A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDC14A gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CDC14A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)1, 2, 3, 9 Li L.... Dixon J.E. (1997)
    2. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. (PubMed id 10409437)1, 2, 3 Wong A.K....Teng D.H. (1999)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with mi crosatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (2010)
    6. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. (PubMed id 15263015)1, 2 Gruneberg U.... Barr F.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)1, 2 Kaiser B.K.... Jackson P.K. (2002)
    9. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)1, 2 Mailand N.... Lukas J. (2002)
    10. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. (PubMed id 11598127)1, 2 Bembenek J. and Yu H. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8556 HGNC: 1718 AceView: CDC14A Ensembl:ENSG00000079335 euGenes: HUgn8556
    ECgene: CDC14A Kegg: 8556 H-InvDB: CDC14A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDC14A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC14A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc14a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDC14A gene:
    Search GeneIP for patents involving CDC14A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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