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CDC14A Gene

protein-coding   GIFtS: 66
GCID: GC01P100817

Cell Division Cycle 14A

(Previous names: CDC10 (cell division cycle 10, S. cerevisiae, homolog),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle 14A1 2     Dual Specificity Protein Phosphatase CDC14A2
CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog)1 2     hCDC142
CDC14 Cell Division Cycle 14 Homolog A2 3     EC 3.1.3.163
CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae)1     EC 3.1.3.483
cdc142     

External Ids:    HGNC: 17181   Entrez Gene: 85562   Ensembl: ENSG000000793357   OMIM: 6035045   UniProtKB: Q9UNH53   

Export aliases for CDC14A gene to outside databases

Previous GC identifers: GC01P101608 GC01P099999 GC01P100108 GC01P100280 GC01P100530 GC01P100590 GC01P098941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDC14A Gene:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is
highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell
mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown
to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of
p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDC14A Gene:
CDC14A (cell division cycle 14A) is a protein-coding gene. Diseases associated with CDC14A include cartilage-hair hypoplasia, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP23.

UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of
mitotic cyclins and subsequent exit from mitosis

Gene Wiki entry for CDC14A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDC14A gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDC14A promoter sequence
   Search Chromatin IP Primers for CDC14A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDC14A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21

CDC14A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P100817:  view genomic region     (about GC identifiers)

Start:
100,810,584 bp from pter      End:
100,985,833 bp from pter
Size:
175,250 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14A  
Size: 594 amino acids; 66574 Da
Subunit: Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle
Sequence caution: Sequence=AAB88277.1; Type=Frameshift; Positions=6;
Secondary accessions: A6MA65 B1AQ14 B1AQ15 O43171 O60727 O60728 Q52LH9 Q8IXX0
Alternative splicing: 5 isoforms:  Q9UNH5-1   Q9UNH5-2   Q9UNH5-3   Q9UNH5-4   Q9UNH5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDC14A: NX_Q9UNH5

Explore proteomics data for CDC14A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDC14A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003663.2  NP_201569.1  NP_201570.1  

    ENSEMBL proteins: 
     ENSP00000388501   ENSP00000354916   ENSP00000359142   ENSP00000336739   ENSP00000442543  
     ENSP00000359143   ENSP00000442640  
    Reactome Protein details: Q9UNH5

    CDC14A Human Recombinant Protein Products:

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    CDC14A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPC: Protein tyrosine phosphatases / Class I Cys-based PTPs : CDC14s

    5 InterPro protein domains:
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR000387 Tyr/Dual-sp_Pase
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR026068 Dual_Pase_CDC14

    Graphical View of Domain Structure for InterPro Entry Q9UNH5

    ProtoNet protein and cluster: Q9UNH5

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: CC14A_HUMAN, Q9UNH5
    Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase
    (DSP) fold (By similarity)
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


    CDC14A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC14A_HUMAN, Q9UNH5
    Function: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell
    division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of
    mitotic cyclins and subsequent exit from mitosis
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for CDC14A:
    cell division cycle 14A,dual specificity serine/threonine-tyrosine phosphatase,involved in cell cycle function and
    in tumorigenesis,with homology to PTEN

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9367992
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI16221885
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016791phosphatase activity ----
         
    CDC14A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDC14A:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDC14A
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    miRNA
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    miRTarBase miRNAs that target CDC14A:
    hsa-mir-424-5p (MIRT000654), hsa-mir-192-5p (MIRT026880), hsa-mir-215-5p (MIRT024403), hsa-mir-503-5p (MIRT000652), hsa-mir-628-3p (MIRT039584)

    Block miRNA regulation of human, mouse, rat CDC14A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDC14A (see all 22):
    hsa-miR-124* hsa-miR-411* hsa-miR-379* hsa-miR-148b hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidCDC14A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDC14A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDC14A (NM_033312)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDC14A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CC14A_HUMAN, Q9UNH5: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis.
    Subsequently localizes to the midzone of the mitotic spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--

    CDC14A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDC14A About    
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase0.00
    Regulation of mitotic cell cycle0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CDC14A
        Cell cycle Role of APC in cell cycle regulation

    1 BioSystems Pathway for CDC14A
        Cell cycle

    1 Reactome Pathway for CDC14A
        Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase


    1 Kegg Pathway  (Kegg details for CDC14A):
        Cell cycle


    CDC14A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CDC14A: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDC14A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDC14A (Q9UNH53 ENSP000003549164) via UniProtKB, MINT, STRING, and/or I2D (see all 303)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation TAS9367992
    GO:0016311dephosphorylation ----
    GO:0051301cell division IEA--

    CDC14A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDC14A (CC14A)

    3 HMDB Compounds for CDC14A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDC14A gene (3 alternative transcripts): 
    NM_003672.3  NM_033312.2  NM_033313.2  

    Unigene Cluster for CDC14A:

    Cell division cycle 14A
    Hs.127411  [show with all ESTs]
    Unigene Representative Sequence: BC071578
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455467 ENST00000361544(uc001dtf.2 uc009wed.1) ENST00000370124(uc001dte.4)
    ENST00000336454 ENST00000469387 ENST00000544534 ENST00000370125(uc009wec.1 uc001dtg.4 uc009wee.3)
    ENST00000542213(uc009web.2 uc010oui.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDC14A (see all 22):
    hsa-miR-124* hsa-miR-411* hsa-miR-379* hsa-miR-148b hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-141*
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDC14A (NM_033312)
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      QuantiTect SYBR Green Assays in human, mouse, rat CDC14A
      QuantiFast Probe-based Assays in human, mouse, rat CDC14A

    Additional mRNA sequence: 

    AB209857.1 AF000367.1 AF064102.1 AF064103.1 AF122013.1 AK302310.1 AK310292.1 AK310657.1 
    BC038979.1 BC071578.1 BC093916.1 BC093918.1 DQ530256.1 

    9 DOTS entries:

    DT.451645  DT.99960713  DT.87015169  DT.97800886  DT.121400440  DT.99971903  DT.121400435  DT.121400450 
    DT.40126932 

    Selected AceView cDNA sequences (see all 59):

    AA283949 Z40824 AI275415 BU631580 F12387 AF122013 BE138724 F10004 
    BG288564 BI831763 AA442512 AI424661 AI093163 AW148548 BC071578 AI039326 
    CA439354 BX476670 BC038979 CB156695 AI028254 AA436714 NM_003672 BM563760 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDC14A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                            -                                                           -                             -     -               
    SP2:                                            -                                                           -                                                   
    SP3:                                            -                       -                                   -                                                   
    SP4:                                            -                                                                                                               
    SP5:        -     -     -                       -                                                                                                               


    ECgene alternative splicing isoforms for CDC14A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDC14A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTGTTA
    CDC14A Expression
    About this image


    CDC14A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocytes Podocyte Layer
             Metanephros
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDC14A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDC14A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127411
        Pathway & Disease-focused RT2 Profiler PCR Array including CDC14A: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDC14A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDC14A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdc14a1 , 5 CDC14 cell division cycle 14 homolog A (S. cerevisiae)5
    CDC14 cell division cycle 14A1
    87.01(n)1
    88.21(a)1
      3 (50.24 cM)5
    2297761  NM_001080818.21  NP_001074287.11 
     1162725535 
    chicken
    (Gallus gallus)
    Aves CDC14A1 CDC14 cell division cycle 14 homolog A (S. cerevisiae) 73.29(n)
    72.88(a)
      424466  NM_001177736.1  NP_001171207.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDC14A6
    cell division cycle 14A
    71(a)
    1 ↔ 1
    4(87534617-87603068)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA987721.12   -- 78.24(n)    CA987721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636542 similar to CDC14 cell division cycle 14 homolog A (S. more 75.41(n)   394124  BC055188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71343 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    63(a)   28C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-141 cdc-14 48.15(n)
    39.62(a)
      173945  NM_001026798.5  NP_001021969.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC14(YFR028C)4 Protein phosphatase required for mitotic exit; located more   --   6(210068-208413) 850585  NP_116684.1 


    ENSEMBL Gene Tree for CDC14A (if available)
    TreeFam Gene Tree for CDC14A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDC14A gene
    DUSP232  CDC14B2  
    4 SIMAP similar genes for CDC14A using alignment to 3 protein entries:     CC14A_HUMAN (see all proteins):
    MGC26484    CDC14B    CDC14C    DUSP23

    CDC14A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDC14A (see all 3274)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356554
    A colorectal cancer sample4--see VAR_0356552 D Y mis40--------
    rs1464781271,2
    C--100816142(+) ATAAC-/AAGAAGGT 3 -- us2k10--------
    rs570725651,2
    C,F--100816283(+) AATTGT/CTGGGG 3 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1882627601,2
    --100816339(+) AAATAC/TAACAA 3 -- us2k10--------
    rs37541301,2
    C--100816459(+) ATAAAA/GTAATT 3 -- us2k14Minor allele frequency- G:0.13WA CSA EA 241
    rs787046311,2
    F--100816471(+) GAGGCC/TTGGCG 3 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1810132951,2
    --100816607(+) TAGCCA/GGGTGT 3 -- us2k10--------
    rs1132847691,2
    C--100816765(+) ACATT-/AAAAAA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs793686781,2
    C--100817005(+) ACAGCC/TTTAGG 3 -- us2k10--------
    rs1446614431,2
    C--100817080(+) TTTAG-/CGGGAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDC14A (100810584 - 100985833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDC14A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272458CNV Insertion20981092
    nsv830815CNV Gain17160897
    nsv830826CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDC14A
    DNA2.0 Custom Variant and Variant Library Synthesis for CDC14A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603504    OMIM disorders: --

    12 diseases for CDC14A:    
    About MalaCards
    cartilage-hair hypoplasia    intrahepatic cholangiocarcinoma    labyrinthitis    cholangiocarcinoma
    breast and colorectal cancer    tonsillitis    colorectal cancer    thyroiditis
    breast cancer    cerebritis    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CDC14A:
    cartilage-hair hypoplasia

    CDC14A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDC14A
    Human Genome Epidemiology (HuGE) Navigator: CDC14A (3 documents)

    Export disorders for CDC14A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDC14A gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with CDC14A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)1, 2, 3, 9 Li L.... Dixon J.E. (J. Biol. Chem. 1997)
    2. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. (PubMed id 10409437)1, 2, 3 Wong A.K.C....Teng D.H.-F. (Genomics 1999)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (APMIS 2010)
    6. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. (PubMed id 15263015)1, 2 Gruneberg U.... Barr F.A. (J. Cell Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)1, 2 Kaiser B.K.... Jackson P.K. (Mol. Biol. Cell 2002)
    9. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)1, 2 Mailand N.... Lukas J. (Nat. Cell Biol. 2002)
    10. Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a. (PubMed id 11598127)1, 2 Bembenek J. and Yu H. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8556 HGNC: 1718 AceView: CDC14A Ensembl:ENSG00000079335 euGenes: HUgn8556
    ECgene: CDC14A Kegg: 8556 H-InvDB: CDC14A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDC14A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDC14A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc14a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDC14A gene:
    Search GeneIP for patents involving CDC14A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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