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Aliases for CDC123 Gene

Aliases for CDC123 Gene

  • Cell Division Cycle 123 2 3
  • C10orf7 3 4
  • HT-1080 3 4
  • D123 3 4
  • PZ32 3 4
  • Cell Division Cycle 123 Homolog (S. Cerevisiae) 2
  • Chromosome 10 Open Reading Frame 7 2
  • Cell Division Cycle 123 Homolog 3
  • Protein D123 4

External Ids for CDC123 Gene

Previous HGNC Symbols for CDC123 Gene

  • C10orf7

Previous GeneCards Identifiers for CDC123 Gene

  • GC10P012278
  • GC10P012154

Summaries for CDC123 Gene

GeneCards Summary for CDC123 Gene

CDC123 (Cell Division Cycle 123) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CDC123 Gene

  • Required for S phase entry of the cell cycle.

Gene Wiki entry for CDC123 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC123 Gene

Genomics for CDC123 Gene

Regulatory Elements for CDC123 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC123 Gene

Chromosome:
10
Start:
12,195,962 bp from pter
End:
12,250,590 bp from pter
Size:
54,629 bases
Orientation:
Plus strand

Genomic View for CDC123 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC123 Gene

Proteins for CDC123 Gene

  • Protein details for CDC123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75794-CD123_HUMAN
    Recommended name:
    Cell division cycle protein 123 homolog
    Protein Accession:
    O75794
    Secondary Accessions:
    • A8JZZ7
    • Q14107
    • Q5T0L4
    • Q5T0L5
    • Q5T0L7
    • Q5T0L8
    • Q5T0L9

    Protein attributes for CDC123 Gene

    Size:
    336 amino acids
    Molecular mass:
    39135 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CDC123 Gene

Proteomics data for CDC123 Gene at MOPED

Post-translational modifications for CDC123 Gene

  • Ubiquitination at Lys 24, Lys 104, Lys 125, Lys 308, Lys 321, Lys 327, and Lys 329
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC123 Gene

No data available for DME Specific Peptides for CDC123 Gene

Domains & Families for CDC123 Gene

Protein Domains for CDC123 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75794

UniProtKB/Swiss-Prot:

CD123_HUMAN :
  • Belongs to the CDC123 family.
Family:
  • Belongs to the CDC123 family.
genes like me logo Genes that share domains with CDC123: view

No data available for Gene Families for CDC123 Gene

Function for CDC123 Gene

Molecular function for CDC123 Gene

UniProtKB/Swiss-Prot Function:
Required for S phase entry of the cell cycle.
genes like me logo Genes that share phenotypes with CDC123: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC123

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDC123 Gene

Localization for CDC123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC123 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDC123 Gene COMPARTMENTS Subcellular localization image for CDC123 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
genes like me logo Genes that share ontologies with CDC123: view

Pathways & Interactions for CDC123 Gene

SuperPathways for CDC123 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IBA --
GO:0006417 regulation of translation IBA --
GO:0007049 cell cycle --
GO:0007050 cell cycle arrest TAS 8601400
GO:0007346 regulation of mitotic cell cycle ISS 15319434
genes like me logo Genes that share ontologies with CDC123: view

No data available for Pathways by source and SIGNOR curated interactions for CDC123 Gene

Drugs & Compounds for CDC123 Gene

No Compound Related Data Available

Transcripts for CDC123 Gene

Unigene Clusters for CDC123 Gene

Cell division cycle 123:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC123

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC123 Gene

No ASD Table

Relevant External Links for CDC123 Gene

GeneLoc Exon Structure for
CDC123
ECgene alternative splicing isoforms for
CDC123

Expression for CDC123 Gene

mRNA expression in normal human tissues for CDC123 Gene

mRNA differential expression in normal tissues according to GTEx for CDC123 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CDC123 Gene

This gene is overexpressed in Bone (29.8), Pancreas (14.4), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC123 Gene



SOURCE GeneReport for Unigene cluster for CDC123 Gene Hs.412842

mRNA Expression by UniProt/SwissProt for CDC123 Gene

O75794-CD123_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.
genes like me logo Genes that share expression patterns with CDC123: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CDC123 Gene

Orthologs for CDC123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC123 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC123 35
  • 89.75 (n)
  • 95.22 (a)
CDC123 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC123 35
  • 91.57 (n)
  • 95.83 (a)
CDC123 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdc123 35
  • 88 (n)
  • 92.26 (a)
Cdc123 16
Cdc123 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDC123 35
  • 99.21 (n)
  • 99.4 (a)
CDC123 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdc123 35
  • 87.8 (n)
  • 93.15 (a)
oppossum
(Monodelphis domestica)
Mammalia CDC123 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDC123 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC123 35
  • 80.4 (n)
  • 86.87 (a)
CDC123 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDC123 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc123 35
  • 74.8 (n)
  • 80.72 (a)
Str.3598 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24014 35
zebrafish
(Danio rerio)
Actinopterygii cdc123 35
  • 68.15 (n)
  • 71.73 (a)
zgc73119 35
cdc123 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008049 35
  • 46.32 (n)
  • 37.93 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR081C 35
  • 47.96 (n)
  • 39.93 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04972g 35
  • 48.65 (n)
  • 38.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC123 35
  • 46.72 (n)
  • 36.74 (a)
CDC123 36
  • 30 (a)
OneToOne
CDC123 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA35 35
  • 48.45 (n)
  • 38.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06497 35
  • 48.6 (n)
  • 40.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP27G11.03 35
  • 49.43 (n)
  • 43.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for CDC123:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC123 Gene

ENSEMBL:
Gene Tree for CDC123 (if available)
TreeFam:
Gene Tree for CDC123 (if available)

Paralogs for CDC123 Gene

No data available for Paralogs for CDC123 Gene

Variants for CDC123 Gene

Sequence variations from dbSNP and Humsavar for CDC123 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7968 -- 12,250,485(+) CTGGG(A/G)AAAAA utr-variant-3-prime
rs10951 -- 12,250,345(+) AGCGT(A/C/G)CTGGA utr-variant-3-prime
rs12126 -- 12,250,566(+) TCTGA(A/T)AATAA utr-variant-3-prime
rs12590 -- 12,250,349(+) TACTG(G/T)AACTG utr-variant-3-prime
rs938991 -- 12,203,602(-) CTCTA(C/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC123 Gene

Variant ID Type Subtype PubMed ID
esv2676569 CNV Deletion 23128226
esv2733106 CNV Deletion 23290073
esv2733117 CNV Deletion 23290073
esv2733128 CNV Deletion 23290073

Variation tolerance for CDC123 Gene

Residual Variation Intolerance Score: 33.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC123 Gene

HapMap Linkage Disequilibrium report
CDC123

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC123 Gene

Disorders for CDC123 Gene

Relevant External Links for CDC123

Genetic Association Database (GAD)
CDC123
Human Genome Epidemiology (HuGE) Navigator
CDC123
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC123
genes like me logo Genes that share disorders with CDC123: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC123 Gene

Publications for CDC123 Gene

  1. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. (PMID: 15319434) Bieganowski P. … Brenner C. (J. Biol. Chem. 2004) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 67
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  5. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. (PMID: 22961080) Li H. … Lin X. (Diabetes 2013) 67

Products for CDC123 Gene

Sources for CDC123 Gene

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