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Aliases for CDC123 Gene

Aliases for CDC123 Gene

  • Cell Division Cycle 123 2 3 5
  • C10orf7 3 4
  • HT-1080 3 4
  • D123 3 4
  • PZ32 3 4
  • Cell Division Cycle 123 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 123 Homolog 3
  • Chromosome 10 Open Reading Frame 7 2
  • Cell Division Cycle 123 Homolog 3
  • Protein D123 4

External Ids for CDC123 Gene

Previous HGNC Symbols for CDC123 Gene

  • C10orf7

Previous GeneCards Identifiers for CDC123 Gene

  • GC10P012278
  • GC10P012154

Summaries for CDC123 Gene

GeneCards Summary for CDC123 Gene

CDC123 (Cell Division Cycle 123) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CDC123 Gene

  • Required for S phase entry of the cell cycle.

Gene Wiki entry for CDC123 Gene

Additional gene information for CDC123 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC123 Gene

Genomics for CDC123 Gene

Regulatory Elements for CDC123 Gene

Enhancers for CDC123 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H012193 1.1 ENCODE 0.7 -0.4 -410 3.4 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 UPF2 NUDT5 CAMK1D CDC123 PIR56929
GH10H012194 0.8 ENCODE 0.7 -2.5 -2486 0.2 YY1 ZNF366 SCRT2 FOS ZNF362 USF2 CEBPB ZEB2 PRDM6 KLF16 SEC61A2 DHTKD1 NUDT5 CDC123 PIR56929
GH10H012190 0.6 ENCODE 0.7 -4.4 -4406 1.7 HLF CEBPB CEBPG ZSCAN9 RAD21 YY1 NFIL3 CEBPA HNF4A MAFK SEC61A2 DHTKD1 NUDT5 CDC123 PIR56929
GH10H012179 0.8 Ensembl ENCODE 0.4 -14.9 -14884 2.8 POLR2A MAX REST MYC SEC61A2 DHTKD1 NUDT5 PIR56929 CDC123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDC123 on UCSC Golden Path with GeneCards custom track

Promoters for CDC123 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024520 138 3001 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Locations for CDC123 Gene

Genomic Locations for CDC123 Gene
chr10:12,195,962-12,250,590
(GRCh38/hg38)
Size:
54,629 bases
Orientation:
Plus strand
chr10:12,237,961-12,292,589
(GRCh37/hg19)

Genomic View for CDC123 Gene

Genes around CDC123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDC123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDC123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC123 Gene

Proteins for CDC123 Gene

  • Protein details for CDC123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75794-CD123_HUMAN
    Recommended name:
    Cell division cycle protein 123 homolog
    Protein Accession:
    O75794
    Secondary Accessions:
    • A8JZZ7
    • Q14107
    • Q5T0L4
    • Q5T0L5
    • Q5T0L7
    • Q5T0L8
    • Q5T0L9

    Protein attributes for CDC123 Gene

    Size:
    336 amino acids
    Molecular mass:
    39135 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CDC123 Gene

Post-translational modifications for CDC123 Gene

  • Ubiquitination at posLast=2424, Lys104, Lys125, posLast=308308, Lys321, posLast=327327, and posLast=329329
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC123 Gene

No data available for DME Specific Peptides for CDC123 Gene

Domains & Families for CDC123 Gene

Gene Families for CDC123 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CDC123 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDC123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75794

UniProtKB/Swiss-Prot:

CD123_HUMAN :
  • Belongs to the CDC123 family.
Family:
  • Belongs to the CDC123 family.
genes like me logo Genes that share domains with CDC123: view

Function for CDC123 Gene

Molecular function for CDC123 Gene

UniProtKB/Swiss-Prot Function:
Required for S phase entry of the cell cycle.

Phenotypes From GWAS Catalog for CDC123 Gene

genes like me logo Genes that share phenotypes with CDC123: view

Animal Models for CDC123 Gene

MGI Knock Outs for CDC123:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDC123 Gene

Localization for CDC123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC123 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDC123 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
genes like me logo Genes that share ontologies with CDC123: view

Pathways & Interactions for CDC123 Gene

SuperPathways for CDC123 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IBA --
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest TAS 8601400
GO:0008284 positive regulation of cell proliferation TAS 8601400
GO:0045948 positive regulation of translational initiation ISS --
genes like me logo Genes that share ontologies with CDC123: view

No data available for Pathways by source and SIGNOR curated interactions for CDC123 Gene

Drugs & Compounds for CDC123 Gene

No Compound Related Data Available

Transcripts for CDC123 Gene

Unigene Clusters for CDC123 Gene

Cell division cycle 123:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC123 Gene

No ASD Table

Relevant External Links for CDC123 Gene

GeneLoc Exon Structure for
CDC123
ECgene alternative splicing isoforms for
CDC123

Expression for CDC123 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDC123 Gene

mRNA differential expression in normal tissues according to GTEx for CDC123 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CDC123 Gene

This gene is overexpressed in Bone (29.8), Pancreas (14.4), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDC123 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDC123 Gene:

CDC123

SOURCE GeneReport for Unigene cluster for CDC123 Gene:

Hs.412842

mRNA Expression by UniProt/SwissProt for CDC123 Gene:

O75794-CD123_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.

Evidence on tissue expression from TISSUES for CDC123 Gene

  • Bone marrow(4.3)
  • Nervous system(3.1)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with CDC123: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDC123 Gene

Orthologs for CDC123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC123 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDC123 33 34
  • 99.21 (n)
oppossum
(Monodelphis domestica)
Mammalia CDC123 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDC123 33 34
  • 91.57 (n)
cow
(Bos Taurus)
Mammalia CDC123 33 34
  • 89.75 (n)
mouse
(Mus musculus)
Mammalia Cdc123 33 16 34
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia Cdc123 33
  • 87.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDC123 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDC123 33 34
  • 80.4 (n)
lizard
(Anolis carolinensis)
Reptilia CDC123 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc123 33
  • 74.8 (n)
Str.3598 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24014 33
zebrafish
(Danio rerio)
Actinopterygii cdc123 33 34
  • 68.15 (n)
zgc73119 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008049 33
  • 46.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04972g 33
  • 48.65 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR081C 33
  • 47.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC123 33 34 36
  • 46.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA35 33
  • 48.45 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP27G11.03 33
  • 49.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06497 33
  • 48.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for CDC123 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC123 Gene

ENSEMBL:
Gene Tree for CDC123 (if available)
TreeFam:
Gene Tree for CDC123 (if available)

Paralogs for CDC123 Gene

No data available for Paralogs for CDC123 Gene

Variants for CDC123 Gene

Sequence variations from dbSNP and Humsavar for CDC123 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000007864 -- 12,233,968(+) AAAAT(-/AGTG)AGAGA intron-variant
rs1000094391 -- 12,217,055(+) AATGT(C/T)GATGT intron-variant
rs1000114906 -- 12,227,817(+) AAATA(A/C)TAGAA intron-variant
rs1000126099 -- 12,230,843(+) CTGGA(A/T)GCTTT intron-variant
rs1000167002 -- 12,239,118(+) CCACT(A/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC123 Gene

Variant ID Type Subtype PubMed ID
esv2676569 CNV deletion 23128226
esv2733106 CNV deletion 23290073
esv2733117 CNV deletion 23290073
esv2733128 CNV deletion 23290073
esv3622363 CNV gain 21293372
esv3891757 CNV gain 25118596
nsv1133971 CNV deletion 24896259
nsv476726 CNV novel sequence insertion 20440878
nsv930475 CNV insertion 23359205

Variation tolerance for CDC123 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDC123 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDC123

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC123 Gene

Disorders for CDC123 Gene

Relevant External Links for CDC123

Genetic Association Database (GAD)
CDC123
Human Genome Epidemiology (HuGE) Navigator
CDC123
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDC123

No disorders were found for CDC123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDC123 Gene

Publications for CDC123 Gene

  1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 45 60
  2. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. (PMID: 19670153) Schleinitz D … Stumvoll M (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2010) 3 45 60
  3. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. (PMID: 19794065) Lango Allen H … Weedon MN (Diabetes 2010) 3 45 60
  4. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. (PMID: 19833888) Simonis-Bik AM … 't Hart LM (Diabetes 2010) 3 45 60
  5. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. (PMID: 19933996) Zhao J … Grant SF (Diabetes 2010) 3 45 60

Products for CDC123 Gene

Sources for CDC123 Gene

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