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Aliases for CDC123 Gene

Aliases for CDC123 Gene

  • Cell Division Cycle 123 2 3
  • C10orf7 3 4
  • HT-1080 3 4
  • D123 3 4
  • PZ32 3 4
  • Cell Division Cycle 123 Homolog (S. Cerevisiae) 2
  • Cell Division Cycle Protein 123 Homolog 3
  • Chromosome 10 Open Reading Frame 7 2
  • Cell Division Cycle 123 Homolog 3
  • Protein D123 4
  • FLJ14640 6
  • CCEP123 6
  • CEP89 6

External Ids for CDC123 Gene

Previous HGNC Symbols for CDC123 Gene

  • C10orf7

Previous GeneCards Identifiers for CDC123 Gene

  • GC10P012278
  • GC10P012154

Summaries for CDC123 Gene

GeneCards Summary for CDC123 Gene

CDC123 (Cell Division Cycle 123) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CDC123 Gene

  • Required for S phase entry of the cell cycle.

Gene Wiki entry for CDC123 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDC123 Gene

Genomics for CDC123 Gene

Regulatory Elements for CDC123 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDC123 Gene

12,195,962 bp from pter
12,250,590 bp from pter
54,629 bases
Plus strand

Genomic View for CDC123 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDC123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDC123 Gene

Proteins for CDC123 Gene

  • Protein details for CDC123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell division cycle protein 123 homolog
    Protein Accession:
    Secondary Accessions:
    • A8JZZ7
    • Q14107
    • Q5T0L4
    • Q5T0L5
    • Q5T0L7
    • Q5T0L8
    • Q5T0L9

    Protein attributes for CDC123 Gene

    336 amino acids
    Molecular mass:
    39135 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI12495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CDC123 Gene

Proteomics data for CDC123 Gene at MOPED

Post-translational modifications for CDC123 Gene

  • Ubiquitination at Lys24, Lys104, Lys125, Lys308, Lys321, Lys327, and Lys329
  • Modification sites at PhosphoSitePlus

Other Protein References for CDC123 Gene

Antibody Products

No data available for DME Specific Peptides for CDC123 Gene

Domains for CDC123 Gene

Protein Domains for CDC123 Gene


Suggested Antigen Peptide Sequences for CDC123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75794
  • Belongs to the CDC123 family.
genes like me logo Genes that share domains with CDC123: view

No data available for Gene Families for CDC123 Gene

Function for CDC123 Gene

Molecular function for CDC123 Gene

UniProtKB/Swiss-Prot Function: Required for S phase entry of the cell cycle.

Phenotypes for CDC123 Gene

genes like me logo Genes that share phenotypes with CDC123: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDC123 Gene

Localization for CDC123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDC123 Gene


Subcellular locations from

Jensen Localization Image for CDC123 Gene COMPARTMENTS Subcellular localization image for CDC123 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
genes like me logo Genes that share ontologies with CDC123: view

Pathways for CDC123 Gene

SuperPathways for CDC123 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDC123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 8601400
GO:0007346 regulation of mitotic cell cycle ISS 15319434
GO:0008284 positive regulation of cell proliferation TAS 8601400
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDC123: view

No data available for Pathways by source for CDC123 Gene

Transcripts for CDC123 Gene

Unigene Clusters for CDC123 Gene

Cell division cycle 123:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDC123

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDC123 Gene

No ASD Table

Relevant External Links for CDC123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDC123 Gene

mRNA expression in normal human tissues for CDC123 Gene

mRNA differential expression in normal tissues according to GTEx for CDC123 Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDC123 Gene

SOURCE GeneReport for Unigene cluster for CDC123 Gene Hs.412842

mRNA Expression by UniProt/SwissProt for CDC123 Gene

Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.
genes like me logo Genes that share expressions with CDC123: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDC123 Gene

Orthologs for CDC123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDC123 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDC123 35
  • 99.21 (n)
  • 99.4 (a)
CDC123 36
  • 99 (a)
(Bos Taurus)
Mammalia CDC123 35
  • 89.75 (n)
  • 95.22 (a)
CDC123 36
  • 95 (a)
(Canis familiaris)
Mammalia CDC123 35
  • 91.57 (n)
  • 95.83 (a)
CDC123 36
  • 96 (a)
(Mus musculus)
Mammalia Cdc123 35
  • 88 (n)
  • 92.26 (a)
Cdc123 16
Cdc123 36
  • 92 (a)
(Monodelphis domestica)
Mammalia CDC123 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CDC123 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Cdc123 35
  • 87.8 (n)
  • 93.15 (a)
(Gallus gallus)
Aves CDC123 35
  • 80.4 (n)
  • 86.87 (a)
CDC123 36
  • 87 (a)
(Anolis carolinensis)
Reptilia CDC123 36
  • 81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24014 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdc123 35
  • 74.8 (n)
  • 80.72 (a)
Str.3598 35
(Danio rerio)
Actinopterygii cdc123 35
  • 68.15 (n)
  • 71.73 (a)
cdc123 36
  • 69 (a)
zgc73119 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008049 35
  • 46.32 (n)
  • 37.93 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR081C 35
  • 47.96 (n)
  • 39.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC123 35
  • 46.72 (n)
  • 36.74 (a)
CDC123 36
  • 30 (a)
CDC123 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04972g 35
  • 48.65 (n)
  • 38.6 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA35 35
  • 48.45 (n)
  • 38.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06497 35
  • 48.6 (n)
  • 40.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAP27G11.03 35
  • 49.43 (n)
  • 43.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for CDC123:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDC123 Gene

Gene Tree for CDC123 (if available)
Gene Tree for CDC123 (if available)

Paralogs for CDC123 Gene

No data available for Paralogs for CDC123 Gene

Variants for CDC123 Gene

Sequence variations from dbSNP and Humsavar for CDC123 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7968 -- 12,250,485(+) CTGGG(A/G)AAAAA utr-variant-3-prime
rs10951 -- 12,250,345(+) AGCGT(A/G)CTGGA utr-variant-3-prime
rs12126 -- 12,250,566(+) TCTGA(A/T)AATAA utr-variant-3-prime
rs12590 -- 12,250,349(+) TACTG(G/T)AACTG utr-variant-3-prime
rs938991 -- 12,203,602(-) CTCTA(C/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDC123 Gene

Variant ID Type Subtype PubMed ID
esv2676569 CNV Deletion 23128226
esv2733106 CNV Deletion 23290073
esv2733117 CNV Deletion 23290073
esv2733128 CNV Deletion 23290073

Relevant External Links for CDC123 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDC123 Gene

Disorders for CDC123 Gene

Relevant External Links for CDC123

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CDC123: view

No data available for UniProtKB/Swiss-Prot for CDC123 Gene

Publications for CDC123 Gene

  1. Genotype score in addition to common risk factors for prediction of type 2 diabetes. (PMID: 19020323) Meigs J.B. … Cupples L.A. (N. Engl. J. Med. 2008) 3 48
  2. Clinical risk factors, DNA variants, and the development of type 2 diabetes. (PMID: 19020324) Lyssenko V. … Groop L. (N. Engl. J. Med. 2008) 3 48
  3. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PMID: 19139842) Lin X. … Mooser V. (Diabetologia 2009) 3 48
  4. Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. (PMID: 19247373) Sanghera D.K. … Ralhan S. (J. Hum. Genet. 2009) 3 48
  5. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. (PMID: 19502414) StancA!kovA! A. … Laakso M. (Diabetes 2009) 3 48

Products for CDC123 Gene

Sources for CDC123 Gene

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