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Aliases for CDAN1 Gene

Aliases for CDAN1 Gene

  • Codanin 1 2 3 5
  • Congenital Dyserythropoietic Anemia, Type I 2 3
  • Discs Lost Homolog 3
  • Codanin-1 3
  • PRO1295 3
  • CDAN1A 3
  • CDA1 3
  • CDAI 3
  • DLT 3

External Ids for CDAN1 Gene

Previous GeneCards Identifiers for CDAN1 Gene

  • GC15U990007
  • GC15M035911
  • GC15M040594
  • GC15M040731
  • GC15M040803
  • GC15M043015
  • GC15M019864

Summaries for CDAN1 Gene

Entrez Gene Summary for CDAN1 Gene

  • This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

GeneCards Summary for CDAN1 Gene

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Dyserythropoietic Anemia, Congenital, Type Ia and Congenital Dyserythropoietic Anemia.

UniProtKB/Swiss-Prot for CDAN1 Gene

  • May act as a negative regulator of ASF1 in chromatin assembly.

Additional gene information for CDAN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDAN1 Gene

Genomics for CDAN1 Gene

Regulatory Elements for CDAN1 Gene

Enhancers for CDAN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H041915 1.4 Ensembl ENCODE dbSUPER 30 +818.2 818204 6.4 FOXA2 ATF1 ZFP64 RAD21 RARA YY1 FOS ATF7 ZC3H11A USF2 SPTBN5 MGA CDAN1 ENSG00000260814 LOC105370792 PLA2G4E-AS1 EHD4 MAPKBP1 STARD9 INO80
GH15H041772 1.6 Ensembl ENCODE dbSUPER 25.8 +961.2 961221 6.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 JMJD7 MGA CDAN1 SPTBN5 VPS39 INO80 ENSG00000260814 ENSG00000250379 JMJD7-PLA2G4B LOC105370792
GH15H042497 1.5 Ensembl ENCODE dbSUPER 19.8 +237.6 237612 4.3 HDGF PKNOX1 ARNT FEZF1 TCF12 GTF3C2 ATF7 FOS MEF2D SMARCA4 LRRC57 TUBGCP4 GANC MGA LCMT2 CDAN1 HAUS2 ENSG00000260814 LOC105370795 RPAP1
GH15H042735 1 ENCODE 23.6 +0.2 243 2.3 FOXA2 ARNT ARID4B SIN3A YY1 ZNF121 GLIS2 ZNF143 ZNF207 SP5 CDAN1 LRRC57 LOC105370795 LCMT2 ZSCAN29 VPS39 GANC CCNDBP1 ENSG00000274403
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDAN1 on UCSC Golden Path with GeneCards custom track

Promoters for CDAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075790 319 1401 HDAC1 RB1 ARID4B KLF17 SIN3A YY1 GLIS2 ZNF143 ZNF207 SMARCA5

Genomic Locations for CDAN1 Gene

Genomic Locations for CDAN1 Gene
13,663 bases
Minus strand

Genomic View for CDAN1 Gene

Genes around CDAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDAN1 Gene

Proteins for CDAN1 Gene

  • Protein details for CDAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6NYD0
    • Q7Z7L5
    • Q969N3

    Protein attributes for CDAN1 Gene

    1227 amino acids
    Molecular mass:
    134120 Da
    Quaternary structure:
    • Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.
    • Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88832.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDAN1 Gene


neXtProt entry for CDAN1 Gene

Post-translational modifications for CDAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDAN1 Gene

No data available for DME Specific Peptides for CDAN1 Gene

Domains & Families for CDAN1 Gene

Gene Families for CDAN1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CDAN1 Gene


Suggested Antigen Peptide Sequences for CDAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDAN1: view

No data available for UniProtKB/Swiss-Prot for CDAN1 Gene

Function for CDAN1 Gene

Molecular function for CDAN1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of ASF1 in chromatin assembly.

Phenotypes From GWAS Catalog for CDAN1 Gene

Gene Ontology (GO) - Molecular Function for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
genes like me logo Genes that share ontologies with CDAN1: view
genes like me logo Genes that share phenotypes with CDAN1: view

Human Phenotype Ontology for CDAN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDAN1 Gene

MGI Knock Outs for CDAN1:

Animal Model Products

CRISPR Products

miRNA for CDAN1 Gene

miRTarBase miRNAs that target CDAN1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDAN1 Gene

Localization for CDAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDAN1 Gene

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDAN1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21364188
GO:0005737 cytoplasm IDA,IEA 22407294
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IEA,IDA 21364188
genes like me logo Genes that share ontologies with CDAN1: view

Pathways & Interactions for CDAN1 Gene

SuperPathways for CDAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IMP 21364188
GO:0008104 protein localization IMP 21364188
GO:0008156 negative regulation of DNA replication IMP 22407294
GO:0031497 chromatin assembly IMP 22407294
genes like me logo Genes that share ontologies with CDAN1: view

No data available for Pathways by source and SIGNOR curated interactions for CDAN1 Gene

Drugs & Compounds for CDAN1 Gene

(1) Drugs for CDAN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDAN1: view

Transcripts for CDAN1 Gene

Unigene Clusters for CDAN1 Gene

Codanin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP2: -

Relevant External Links for CDAN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDAN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.5), Adipocyte (18.2), Peripheral blood mononuclear cells (12.8), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDAN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDAN1 Gene:


SOURCE GeneReport for Unigene cluster for CDAN1 Gene:


mRNA Expression by UniProt/SwissProt for CDAN1 Gene:

Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells.

Evidence on tissue expression from TISSUES for CDAN1 Gene

  • Kidney(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDAN1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • lymphatic
  • nervous
  • respiratory
Head and neck:
  • ear
  • eye
  • head
  • mouth
  • heart
  • lung
  • kidney
  • liver
  • spleen
  • placenta
  • uterus
  • blood
  • blood vessel
  • bone marrow
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with CDAN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDAN1 Gene

Orthologs for CDAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDAN1 33 34
  • 99.27 (n)
(Bos Taurus)
Mammalia CDAN1 33 34
  • 88.4 (n)
(Canis familiaris)
Mammalia CDAN1 33 34
  • 87.28 (n)
(Mus musculus)
Mammalia Cdan1 33 16 34
  • 86.62 (n)
(Rattus norvegicus)
Mammalia Cdan1 33
  • 86.19 (n)
(Monodelphis domestica)
Mammalia CDAN1 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CDAN1 34
  • 69 (a)
(Gallus gallus)
Aves CDAN1 33 34
  • 62.79 (n)
(Anolis carolinensis)
Reptilia CDAN1 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdan1 33
  • 58.58 (n)
(Danio rerio)
Actinopterygii cdan1 33 34
  • 55.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010055 33
  • 42.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta dlt 33 34
  • 40.96 (n)
Species where no ortholog for CDAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDAN1 Gene

Gene Tree for CDAN1 (if available)
Gene Tree for CDAN1 (if available)

Paralogs for CDAN1 Gene

No data available for Paralogs for CDAN1 Gene

Variants for CDAN1 Gene

Sequence variations from dbSNP and Humsavar for CDAN1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs120074166 Pathogenic, Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,731,275(-) GCTCA(A/G)TGGTC nc-transcript-variant, reference, missense
rs120074167 Pathogenic, Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,730,757(-) CCCTC(C/T)GGTCC nc-transcript-variant, reference, missense
rs120074168 Pathogenic, Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,729,066(-) TAGAG(A/T)TCGTG nc-transcript-variant, reference, missense
rs370895637 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,729,063(+) TGCCA(C/G/T)GAACT nc-transcript-variant, reference, missense
rs80338696 Pathogenic, Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,730,632(-) ATTAC(C/T)GGGAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDAN1 Gene

Variant ID Type Subtype PubMed ID
nsv952615 CNV deletion 24416366
nsv569238 CNV loss 21841781
nsv528725 CNV gain 19592680
nsv517553 CNV gain+loss 19592680
nsv457122 CNV loss 19166990

Variation tolerance for CDAN1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.08; 99.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDAN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDAN1 Gene

Disorders for CDAN1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDAN1 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type ia
  • congenital dyserythropoietic anemia type i
congenital dyserythropoietic anemia
  • congenital dyshaematopoietic anaemia
angioid streaks
macrocytic anemia
  • anemia macrocytic
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search CDAN1 in MalaCards View complete list of genes associated with diseases


  • Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120]: An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. {ECO:0000269 PubMed:12434312}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDAN1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDAN1: view

No data available for Genatlas for CDAN1 Gene

Publications for CDAN1 Gene

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PMID: 12434312) Dgany O … Tamary H (American journal of human genetics 2002) 2 3 4 22 60
  2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 60
  3. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts. (PMID: 21364188) Renella R … Wood WG (Blood 2011) 3 4 60
  4. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PMID: 19336738) Noy-Lotan S … Tamary H (Haematologica 2009) 3 22 60
  5. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PMID: 18081704) Tamary H … Delaunay J (European journal of haematology 2008) 3 22 60

Products for CDAN1 Gene

Sources for CDAN1 Gene

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