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Aliases & Descriptions for CDAN1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CDA-I 1, 2 | | CDA1 2, 5 | | CDAI 1, 2 | | DLT 2 | | PRO1295 2 | | codanin 1, 2 |
| | | Descriptions |
|---|
| codanin 1 2 | | congenital dyserythropoietic anemia, type I 2 |
|
| | Search outside databases for aliases for CDAN1 genePrevious GC identifers: GC15U990007 GC15M035911 GC15M040594 GC15M040731 |
Summaries for CDAN1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9Function: Might be involved in nuclear membrane integrity |
Genomic Location for CDAN1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CDAN1 gene 
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q15.2CDAN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M040803:
(about GC identifiers)
Start:
|
40,803,052 bp from pter |
End:
|
40,816,709 bp from pter |
Size:
|
13,658 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000015.8 NT_010194.16
| Proteins for CDAN1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9 (See
protein sequence)Recommended Name: Codanin-1 Size: 1227 amino acids; 134180 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6NYD0 Q7Z7L5 Q969N3Alternative splicing: 3 isoforms: Q8IWY9-2 Q8IWY9-1 Q8IWY9-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_612486.2
ENSEMBL proteins: ENSP00000348564 ENSP00000267892
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for CDAN1: Assays for CDAN1: | Protein
Domains/ Families for CDAN1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IWY9 | Gene Function for CDAN1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138477
Applied Biosystems Silencer® siRNAs for CDAN1
Sigma-Aldrich siRNA for CDAN1  Sigma-Aldrich shRNA for CDAN1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138477                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138477                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138477 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_138477
UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9Function: Might be involved in nuclear membrane integrity1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for CDAN1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/11 Interacting proteins for CDAN1 (Q8IWY91, 2 ENSP000003485643) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
|
Drugs & Compounds for CDAN1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CDAN1 1 Novoseek chemical compound relationship for CDAN1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iron |
17.90 |
1 |
15278299 (1) |
About this table
|
Transcripts for CDAN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138477
Sigma-Aldrich siRNA for CDAN1  Sigma-Aldrich shRNA for CDAN1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_138477 REFSEQ mRNAs for CDAN1 gene: NM_138477.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138477               OriGene GFP tagged cDNA clone in CMV expression vector: NM_138477                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138477                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138477  Additional cDNA sequence: AF525398.1 BC001092.2 BC008333.1 BC008334.1 BC052568.1 BC066640.1 BC113821.1 6 DOTS entries: DT.95366941 DT.308276 DT.86852416 DT.99952073 DT.121018323 DT.97858479 24/62 AceView cDNA sequences (see all 62
):BC001092 BM666638 F33063 AI567437 AI205627 BC008333 BM702052 BC066640 AL133019 BC008334 BM459709 Z38431 BM469318 Z42172 BE674802 BC052568 CF135838 BM987960 BU855835 AI122852 AI951606 BF510110 BU552398 AI199106
highest scoring ESTs for CDAN1:BC052568 BC066640 BU553057 BU855835 CB990148 AA355100 AF525398 AI122852 AI205627 AI873758 Unigene Cluster for CDAN1: Congenital dyserythropoietic anemia, type I Hs.599232 [show with all ESTs]Unigene Representative Sequence: NM_138477
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for CDAN1
2 Ensembl transcripts including schematic representations: ENST00000356231
ENST00000267892
|
Expression for CDAN1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CDAN1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CDAN1
1 / 2 / 3 5 probe-sets matching CDAN1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACAGAGGCAA
SOURCE GeneReport for Unigene cluster: Hs.599232 UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells |
Orthologs for CDAN1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDAN1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for CDAN1
ENSEMBL Gene Tree for CDAN1 | Paralogs for CDAN1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for CDAN1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CDAN1 (up to first 250kb)
|
Disorders & Mutations for CDAN1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607465 disorders: 224120 UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9
Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type I (CDAI) [MIM:224120]. CDAI is an autosomal recessive disease characterized by morphological and functional abnormalities of erythropoiesis. Ultrastructural erythroid features include spongy heterochromatin and invagination of the nuclear membrane, carrying cytoplasm and cytoplasmic organelles into the nucleus. Patients with CDAI present moderate to severe macrocytic anemia2 Novoseek disease relationships for CDAN1 gene
About this table
GeneTests: CDAN1 Congenital Dyserythropoietic Anemia Type I Human Gene Mutation Database: CDAN1
|
Medical News for CDAN1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CDAN1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/17 PubMed articles for CDAN1 gene (see all 17
):- Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PubMed id 12434312)1, 2, 3, 4 Dgany O....Tamary H. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. (PubMed id 8634422)2, 3 Tamary H....Zaizov R. (1996)
- Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PubMed id 18081704)1, 3 Tamary H....Delaunay J. (2008)
- Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. (PubMed id 16767397)1, 3 Goede J.S....Heimpel H. (2006)
- Congenital dyserythropoietic anemia in a Chinese family with a mutation of the CDAN1-gene. (PubMed id 18575862)3 Ru Y.X....Heimpel H. (2008)
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)3 Melzer D....Ferrucci L. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for CDAN1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CDAN1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CDAN1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDAN1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| Licensable Technologies for CDAN1 gene:
| Services for CDAN1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CDAN1:

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Incremental update: 13 Oct 2009
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