Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDAN1 Gene

protein-coding GIFtS: 51
GCID: GC15M043015

codanin 1

(Previous names: congenital dyserythropoietic anemia, type I )

Explore 17 diseases affiliated with
CDAN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Codanin 1¹ ²		DLT²
CDAI¹ ²		PRO1295²
Congenital Dyserythropoietic Anemia, Type I¹ ²		Codanin-1¹
CDA1² ⁵		Discs Lost Homolog²
CDA-I¹

External Ids:	HGNC: 1713¹	Entrez Gene: 146059²	Ensembl: ENSG00000140326⁷	OMIM: 607465⁵	UniProtKB: Q8IWY9³

Export aliases for CDAN1 gene to outside databases

Previous GC identifers: GC15U990007 GC15M035911 GC15M040594 GC15M040731 GC15M040803 GC15M019864

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDAN1:

This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule

attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in

morphological and functional abnormalities of erythropoiesis. (provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9

Function: May acts as a negative regulator of ASF1 in chromatin assembly

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDAN1 gene promoter:
Pax-5 p53 Olf-1 STAT5A Cdc5 RORalpha2 PPAR-gamma1 Cart-1 STAT3 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDAN1 promoter sequence

Search SABiosciences Chromatin IP Primers for CDAN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDAN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q15.2

CDAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDAN1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M043015: view genomic region (about GC identifiers)

Start:	43,015,757 bp from pter	End:	43,029,417 bp from pter
Size:	13,661 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9 (See protein sequence)

Recommended Name: Codanin-1

Size: 1227 amino acids; 134120 Da

Subunit: Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4

Subcellular location: Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein (Potential). Note=Mainly detected as a

cytoplasmic protein

Sequence caution: Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAQ88832.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q6NYD0 Q7Z7L5 Q969N3

Alternative splicing: 3 isoforms: Q8IWY9-2 Q8IWY9-1 Q8IWY9-3

Explore the universe of human proteins at neXtProt for CDAN1: NX_Q8IWY9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWY9

CDAN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_612486.2

ENSEMBL proteins:

ENSP00000454246 ENSP00000348564 ENSP00000455536

Human Recombinant Protein Products for CDAN1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CDAN1 OriGene Protein Over-expression Lysate: CDAN1 OriGene Custom Protein Services for CDAN1
	GenScript Custom Purified and Recombinant Proteins Services for CDAN1
	Novus Biologicals CDAN1 Protein Novus Biologicals CDAN1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDAN1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0016021	integral to membrane	IEA	--

CDAN1 for ontologies About GeneDecksing

CDAN1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CDAN1
	GenScript Custom Superior Antibodies Services for CDAN1
	Novus Biologicals CDAN1 Antibody
	Abcam antibodies for CDAN1
	Uscn Antibodies for CDAN1
	Search ThermoFisher Antibodies for CDAN1

Assay Products for CDAN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDAN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDAN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8IWY9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDAN1_HUMAN, Q8IWY9

Function: May acts as a negative regulator of ASF1 in chromatin assembly

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

CDAN1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CDAN1:

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdan1):

mortality/aging

normal

CDAN1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDAN1

miRNA Products:		OriGene 3'-UTR Clone: CDAN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDAN1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDAN1:
		hsa-miR-146b-3p hsa-miR-3918 hsa-miR-4267 hsa-miR-150 hsa-miR-3667-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CDAN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDAN1 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDAN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDAN1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CDAN1
			Sirion Biotech Customized adenovirus for overexpression of CDAN1 Sirion Biotech Customized adenovirus for potent knockdown of CDAN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDAN1 (NM_138477)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDAN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDAN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDAN1
		Search LifeMap BioReagents cell lines for CDAN1
		Sirion Biotech Customized stable knockdown cell line services for CDAN1 Sirion Biotech Customized inducible knockdown cell line services for CDAN1 Sirion Biotech Customized stable overexpressing cell line services for CDAN1 Sirion Biotech Customized inducible overexpressing cell line services for CDAN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDAN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDAN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/13 Interacting proteins for CDAN1 (Q8IWY9^{2, 3} ENSP00000348564⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASF1B	Q9NVP2²^,³, ENSP00000263382⁴	MINT-8408119 MINT-8408142 I2D: score=2 STRING: ENSP00000263382
ASF1A	Q9Y294², ENSP00000229595⁴	MINT-8408119 MINT-8408142 STRING: ENSP00000229595
IPO4	Q8TEX9², ENSP00000346453⁴	MINT-8388465 STRING: ENSP00000346453
PDPK1	O15530³	I2D: score=4
EBF1	Q9UH73³	I2D: score=3

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008156	negative regulation of DNA replication	IMP	--
GO:0031497	chromatin assembly	IMP	--

CDAN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDAN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDAN1
1 Novoseek chemical compound relationship for CDAN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	16.7	1	15278299 (1)

Search CenterWatch for drugs/clinical trials and news about CDAN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDAN1 gene:

NM_138477.2

Unigene Cluster for CDAN1:

Codanin 1

Hs.599232 [show with all ESTs]

Unigene Representative Sequence: NM_138477

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562465(uc001zqj.3) ENST00000563604 ENST00000356231(uc001zqk.3 uc001zql.3 uc010bcx.1)

ENST00000565930 ENST00000563260

miRNA Products:		OriGene 3'-UTR Clone: CDAN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDAN1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDAN1:
		hsa-miR-146b-3p hsa-miR-3918 hsa-miR-4267 hsa-miR-150 hsa-miR-3667-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CDAN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDAN1 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDAN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDAN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDAN1 (NM_138477)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDAN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDAN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDAN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CDAN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDAN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDAN1

Additional cDNA sequence:

AF525398.1 BC001092.2 BC008333.1 BC008334.1 BC052568.1 BC066640.1 BC113821.1

6 DOTS entries:

DT.95366941 DT.308276 DT.86852416 DT.99952073 DT.121018323 DT.97858479

24/62 AceView cDNA sequences (see all 62):

BM666638 AL133019 AI205627 BC001092 BC066640 AI567437 BC008334 Z42172

BC052568 F33063 BM459709 BM469318 BE674802 Z38431 BM702052 BC008333

BM987960 CF135838 BF510110 AI122852 AI927127 AI199106 BU552398 BX113878

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^
SP1:					-
SP2:
SP3:
SP4:

ExUns:	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26	^	27	^	28
SP1:
SP2:							-
SP3:
SP4:

ECgene alternative splicing isoforms for CDAN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDAN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGAGGCAA

About this image

CDAN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDAN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDAN1

SOURCE GeneReport for Unigene cluster: Hs.599232

UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9

Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells

SABiosciences Custom PCR Arrays for CDAN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDAN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CDAN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDAN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDAN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDAN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdan1^{1 , 5}	congenital dyserythropoietic anemia, type I (human)^{1, 5}	86.62(n)¹ 88.74(a)¹		2 (60.37 cM)⁵ 68968¹ NM_026891.2¹ NP_081167.2¹ 120716522⁵
chicken (Gallus gallus)	Aves	CDAN1¹	congenital dyserythropoietic anemia, type I	61.46(n) 58.61(a)		423239 XM_421163.3 XP_421163.3
lizard (Anolis carolinensis)	Reptilia	CDAN1⁶	--	53(a)	1 ↔ 1	1(39653575-39696210)
zebrafish (Danio rerio)	Actinopterygii	LOC565314¹	codanin-1-like	54.89(n) 49.31(a)		565314 XM_688592.5 XP_693684.5
fruit fly (Drosophila melanogaster)	Insecta	dlt¹	discs lost	40.52(n) 29.58(a)		46719 NM_167916.2 NP_728672.1

ENSEMBL Gene Tree for CDAN1 (if available)
TreeFam Gene Tree for CDAN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4265781^1,2	C,A	non-pathogenic	21560683(+)	`TGCTCA/TGGGCC`	2	Q L	mis¹ ese³		6		NA WA CSA	245
rs12441516^1,2	C,H	non-pathogenic	21560749(+)	`GCTCGC/TGGGCC`	2	H R	mis¹ ese³		0	--	--	--	--
rs12917189^1,2	C,F,A,H	non-pathogenic	21565954(+)	`GCTCCC/TGGATC`	2	Q R	mis¹ ese³		35		EA NA NS WA CSA EU	8814
rs8023524^1,2	C,F,H	non-pathogenic	21568453(+)	`CTGGCA/GCACCA`	2	R C	mis¹ ese³		24		EA NA NS WA CSA EU	7347
rs120074167^1,2	C	pathogenic	21566481(-)	`CCCTCC/TGGTCC`	2	P L	mis¹		0	--	--	--	--
rs80338696^1,2	C	pathogenic	21566606(-)	`ATTACC/TGGGAC`	2	R W	mis¹		0	--	--	--	--
rs80338697^1,2	C	pathogenic	21570848(-)	`GGCCAC/TGGGAC`	2	R W	mis¹		0	--	--	--	--
rs80338699^1,2	C	pathogenic	21571688(-)	`GGTTCC/TGCTGC`	2	P L	mis¹		0	--	--	--	--
rs79535735^1,2	F	--	19864286(+)	`CCACCC/TGAGAC`	1	--	ds500¹		1		WA	118
rs11857216^1,2	H	--	19865430(+)	`AAAAGG/CCAGCA`	1	--	int¹ trp³		4		NS EA	404

HapMap Linkage Disequilibrium report for CDAN1 (43015757 - 43029417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDAN1
1 CNV: 49555
Human Gene Mutation Database (HGMD): CDAN1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDAN1

DNA2.0 Custom Variant and Variant Library Synthesis for CDAN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDAN1 for disorders           About GeneDecksing

OMIM gene information: 607465
OMIM disorders: 224120
UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9

Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1) [MIM:224120]. An autosomal

recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis,

macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of

the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear

chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or

Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts

17 diseases for CDAN1: About MalaCards

congenital dyserythropoietic anemia type i congenital dyserythropoietic anemia dyserythropoietic anemia anemia

angioid streaks macrocytic anemia acrodysostosis male infertility

blood disorders peripheral neuropathy scoliosis hemochromatosis

infertility neutropenia diarrhea neuropathy

retinitis

3 diseases from the University of Copenhagen DISEASES database for CDAN1:

Neutropenia Diarrhea Thrombocytopenia

2 Novoseek disease relationships for CDAN1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cda i	99.1	16	15278299 (2), 16098079 (2), 19336738 (2), 16767397 (2) (see all 7)
anemia	43.5	1	18081704 (1)

GeneTests: CDAN1

Congenital Dyserythropoietic Anemia Type I

Export disorders for CDAN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDAN1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CDAN1)

Utopia: connect your pdf to the dynamic
world of online information

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PubMed id 12434312)^{1, 2, 3, 9} Dgany O.... Tamary H. (2002)
Codanin-1, mutated in the anaemic disease CDAI, regula tes Asf1 function in S-phase histone supply. (PubMed id 22407294)^{1, 2} Ask K....Groth A. (2012)
Codanin-1 mutations in congenital dyserythropoietic a nemia type 1 affect HP1{alpha} localization in erythroblasts. (PubMed id 21364188)^{1, 2} Renella R....Wood W.G. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. (PubMed id 8634422)^{1, 3} Tamary H....Zaizov R. (1996)
Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PubMed id 19336738)^{1, 9} Noy-Lotan S....Tamary H. (2009)
Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PubMed id 18081704)^{1, 9} Tamary H....Delaunay J. (2008)
Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. (PubMed id 16767397)^{1, 9} Goede J.S....Heimpel H. (2006)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 146059	HGNC: 1713	AceView: CDAN1	Ensembl:ENSG00000140326	euGenes: HUgn146059
ECgene: CDAN1	H-InvDB: CDAN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDAN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDAN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDAN1 gene:
Search GeneIP for patents involving CDAN1

Licensable Technologies for CDAN1 gene:

Weizmann Institute:

A Novel Erythrocyte Differentiation Factor

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDAN1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDAN1
	OriGene Protein Over-expression Lysate for CDAN1		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for CDAN1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDAN1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CDAN1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CDAN1		OriGene Custom Protein Services for CDAN1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDAN1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDAN1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDAN1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDAN1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDAN1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDAN1

	GenScript Custom Purified and Recombinant Proteins Services for CDAN1		GenScript cDNA clones with any tag delivered in your preferred vector for CDAN1
	GenScript Custom Assay Services for CDAN1		GenScript Custom Superior Antibodies Services for CDAN1
	GenScript Custom overexpressing Cell Line Services for CDAN1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CDAN1 promoter
	Search Chromatin IP Primers for CDAN1
	RT² qPCR Primer Assay in human, mouse / rat CDAN1
	Search GNC Networks for CDAN1
	SABiosciences Custom PCR Arrays for CDAN1

Search Tocris compounds for CDAN1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CDAN1 antibodies
	CDAN1 proteins
	CDAN1 lysates

	Antibodies for CDAN1
	See all of Abcam's Antibodies, Kits and Proteins for CDAN1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CDAN1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CDAN1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDAN1

	SwitchGear 3'UTR luciferase reporter plasmids for CDAN1
	SwitchGear Promoter luciferase reporter plasmids for CDAN1

Search ThermoFisher Antibodies for CDAN1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDAN1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDAN1

Sirion Biotech Customized:

	stable knockdown cell line services for CDAN1
	inducible knockdown cell line services for CDAN1
	design and validation of potent shRNA sequences against CDAN1
	adenovirus for potent knockdown of CDAN1
	adenovirus for overexpression of CDAN1
	stable overexpressing cell line services for CDAN1
	inducible overexpressing cell line services for CDAN1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDAN1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CDAN1 Gene

codanin 1

Aliases
for CDAN1 gene

Summaries
for CDAN1 gene

Genomic Views
for CDAN1 gene

Proteins
for CDAN1 gene

Protein Domains /
Families
for CDAN1 gene

Function
for CDAN1 gene

Pathways & Interactions
for CDAN1 gene

Drugs & Compounds
for CDAN1 gene

Transcripts
for CDAN1 gene

Expression
for CDAN1 gene

Orthologs
for CDAN1 gene

Paralogs
for CDAN1 gene

Genomic Variants
for CDAN1 gene

Disorders / Diseases
for CDAN1 gene

Publications
for CDAN1 gene

External Searches for CDAN1 gene

Genome Databases showing CDAN1 gene

Other Databases showing CDAN1 gene

Specialized Databases showing CDAN1 gene

Intellectual Property
for CDAN1 gene

Products
for CDAN1 gene

View Random Gene

Advanced Search

Export list of displayed genes

CDAN1 Gene

codanin 1

Aliasesfor CDAN1 gene

Summariesfor CDAN1 gene

Genomic Viewsfor CDAN1 gene

Proteinsfor CDAN1 gene

Protein Domains /Familiesfor CDAN1 gene

Functionfor CDAN1 gene

Pathways & Interactionsfor CDAN1 gene

Drugs & Compoundsfor CDAN1 gene

Transcriptsfor CDAN1 gene

Expression for CDAN1 gene

Orthologsfor CDAN1 gene

Paralogsfor CDAN1 gene

Genomic Variantsfor CDAN1 gene

Disorders / Diseasesfor CDAN1 gene

Publicationsfor CDAN1 gene

External Searches for CDAN1 gene

Genome Databases showing CDAN1 gene

Other Databases showing CDAN1 gene

Specialized Databases showing CDAN1 gene

Intellectual Propertyfor CDAN1 gene

Productsfor CDAN1 gene

View Random Gene

Aliases
for CDAN1 gene

Summaries
for CDAN1 gene

Genomic Views
for CDAN1 gene

Proteins
for CDAN1 gene

Protein Domains /
Families
for CDAN1 gene

Function
for CDAN1 gene

Pathways & Interactions
for CDAN1 gene

Drugs & Compounds
for CDAN1 gene

Transcripts
for CDAN1 gene

Expression
for CDAN1 gene

Orthologs
for CDAN1 gene

Paralogs
for CDAN1 gene

Genomic Variants
for CDAN1 gene

Disorders / Diseases
for CDAN1 gene

Publications
for CDAN1 gene

Intellectual Property
for CDAN1 gene

Products
for CDAN1 gene