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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDAN1 Gene

protein-coding   GIFtS: 53
GCID: GC15M043015

Codanin 1

(Previous names: congenital dyserythropoietic anemia, type I)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Codanin 11 2     DLT2
Congenital Dyserythropoietic Anemia, Type I1 2     PRO12952
CDA12 5     codanin-12
CDAI2     Discs Lost Homolog2

External Ids:    HGNC: 17131   Entrez Gene: 1460592   Ensembl: ENSG000001403267   OMIM: 6074655   UniProtKB: Q8IWY93   

Export aliases for CDAN1 gene to outside databases

Previous GC identifers: GC15U990007 GC15M035911 GC15M040594 GC15M040731 GC15M040803 GC15M019864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDAN1 Gene:
This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to
microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease
resulting in morphological and functional abnormalities of erythropoiesis. (provided by RefSeq, Jul 2009)

GeneCards Summary for CDAN1 Gene: 
CDAN1 (codanin 1) is a protein-coding gene. Diseases associated with CDAN1 include congenital dyserythropoietic anemia, and congenital dyserythropoietic anemia type i. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9
Function: May acts as a negative regulator of ASF1 in chromatin assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDAN1 gene promoter:
         Pax-5   p53   Olf-1   STAT5A   Cdc5   RORalpha2   PPAR-gamma1   Cart-1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDAN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDAN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDAN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15.2

CDAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDAN1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M043015:  view genomic region     (about GC identifiers)

Start:
43,015,757 bp from pter      End:
43,029,417 bp from pter
Size:
13,661 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9 (See protein sequence)
Recommended Name: Codanin-1  
Size: 1227 amino acids; 134120 Da
Subunit: Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4
Subcellular location: Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein (Potential). Note=Mainly detected
as a cytoplasmic protein
Sequence caution: Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAQ88832.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NYD0 Q7Z7L5 Q969N3
Alternative splicing: 3 isoforms:  Q8IWY9-2   Q8IWY9-1   Q8IWY9-3   

Explore the universe of human proteins at neXtProt for CDAN1: NX_Q8IWY9

Explore proteomics data for CDAN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWY9

  • CDAN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDAN1 Protein Expression
    REFSEQ proteins: NP_612486.2  
    ENSEMBL proteins: 
     ENSP00000454246   ENSP00000348564   ENSP00000455536  

    Human Recombinant Protein Products for CDAN1: 
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    Novus Biologicals CDAN1 Protein
    Novus Biologicals CDAN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDAN1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral to membrane IEA--

    CDAN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IWY9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDAN1_HUMAN, Q8IWY9
    Function: May acts as a negative regulator of ASF1 in chromatin assembly

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CDAN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDAN1:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdan1):
     mortality/aging  normal 

    CDAN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDAN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDAN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDAN1 
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    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDAN1:
    hsa-miR-146b-3p hsa-miR-3918 hsa-miR-4267 hsa-miR-150 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDAN1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDAN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/13 Interacting proteins for CDAN1 (Q8IWY92, 3 ENSP000003485644) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASF1BQ9NVP22, 3, ENSP000002633824MINT-8408119 MINT-8408142 I2D: score=2 STRING: ENSP00000263382
    ASF1AQ9Y2942, ENSP000002295954MINT-8408119 MINT-8408142 STRING: ENSP00000229595
    IPO4Q8TEX92, ENSP000003464534MINT-8388465 STRING: ENSP00000346453
    PDPK1O155303I2D: score=4 
    EBF1Q9UH733I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008156negative regulation of DNA replication IMP--
    GO:0031497chromatin assembly IMP--

    CDAN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDAN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDAN1

    1 Novoseek inferred chemical compound relationship for CDAN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 16.7 1 15278299 (1)

    Search CenterWatch for drugs/clinical trials and news about CDAN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDAN1 gene: 
    NM_138477.2  

    Unigene Cluster for CDAN1:

    Codanin 1
    Hs.599232  [show with all ESTs]
    Unigene Representative Sequence: NM_138477
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562465(uc001zqj.3) ENST00000563604 ENST00000356231(uc001zqk.3 uc001zql.3 uc010bcx.1)
    ENST00000565930 ENST00000563260
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDAN1:
    hsa-miR-146b-3p hsa-miR-3918 hsa-miR-4267 hsa-miR-150 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDAN1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDAN1

    Additional mRNA sequence: 

    AF525398.1 BC001092.2 BC008333.1 BC008334.1 BC052568.1 BC066640.1 BC113821.1 

    6 DOTS entries:

    DT.95366941  DT.308276  DT.86852416  DT.99952073  DT.121018323  DT.97858479 

    24/62 AceView cDNA sequences (see all 62):

    F33063 BC008333 BM459709 BM469318 BC066640 BC001092 Z42172 BC052568 
    AI567437 AI205627 BM666638 BE674802 Z38431 BC008334 BM702052 AL133019 
    BF510110 AI951606 AI122852 R74370 AW292960 BX113878 BU553057 AI927127 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:              -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                                            
    SP2:                    -                                       
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for CDAN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDAN1 expression in normal human tissues (normalized intensities)      CDAN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGAGGCAA
    CDAN1 Expression
    About this image


    CDAN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
             brain/midbrain/lateral wall   
     
     Ovary (Reproductive System)

    See CDAN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDAN1

    SOURCE GeneReport for Unigene cluster: Hs.599232

    UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9
    Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDAN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDAN1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdan11 , 5 congenital dyserythropoietic anemia, type I (human)1, 5 86.62(n)1
    88.74(a)1
      2 (60.37 cM)5
    689681  NM_026891.21  NP_081167.21 
     1207165225 
    chicken
    (Gallus gallus)
    Aves CDAN11 congenital dyserythropoietic anemia, type I 61.46(n)
    58.61(a)
      423239  XM_421163.3  XP_421163.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDAN16
    codanin 1
    50(a)
    1 ↔ 1
    1(39652578-39696210)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5653141 codanin-1-like 54.89(n)
    49.31(a)
      565314  XM_688592.5  XP_693684.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta dlt1 discs lost 40.52(n)
    29.58(a)
      46719  NM_167916.2  NP_728672.1 


    ENSEMBL Gene Tree for CDAN1 (if available)
    TreeFam Gene Tree for CDAN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/573 SNPs in CDAN1 are shown (see all 573)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0172244
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172242 R W mis40--------
    VAR_0172204
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172202 E K mis40--------
    VAR_0172264
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172262 P L mis40--------
    VAR_0172254
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172252 D V mis40--------
    VAR_0172194
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172192 P L mis40--------
    VAR_0172224
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172222 F I mis40--------
    VAR_0172184
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172182 N S mis40--------
    VAR_0172234
    Congenital dyserythropoietic anemia 1 (CDA1)4--see VAR_0172232 V M mis40--------
    rs803386961,2,4
    CCongenital dyserythropoietic anemia 1 (CDA1)4 pathogenic123088678(-) ATTACC/TGGGAC 2 R W mis10--------
    rs80235241,2,4
    C,F,Hnon-pathogenic123086831(+) CTGGCA/GCACCA 2 R C mis1 ese324Minor allele frequency- N:0.00EA NA NS WA CSA EU 7347

    HapMap Linkage Disequilibrium report for CDAN1 (43015757 - 43029417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDAN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv457122CNV Loss19166990
    nsv528725CNV Gain19592680
    nsv517553CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CDAN1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDAN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDAN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607465   
    OMIM disorders: 224120  
    UniProtKB/Swiss-Prot: CDAN1_HUMAN, Q8IWY9
  • Congenital dyserythropoietic anemia 1 (CDA1) [MIM:224120]: An autosomal recessive blood disorder
    characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and
    secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and
    feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin
    bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or
    Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 17 diseases for CDAN1:    About MalaCards
    congenital dyserythropoietic anemia    congenital dyserythropoietic anemia type i    angioid streaks    blood disorders
    macrocytic anemia    acrodysostosis    anemia    scoliosis
    hemochromatosis    male infertility    peripheral neuropathy    diarrhea
    neutropenia    thrombocytopenia    infertility    neuropathy
    retinitis

    3 diseases from the University of Copenhagen DISEASES database for CDAN1:
    Neutropenia     Diarrhea     Thrombocytopenia

    CDAN1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CDAN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cda i 99.1 16 15278299 (2), 16098079 (2), 19336738 (2), 16767397 (2) (see all 7)
    anemia 43.5 1 18081704 (1)

    GeneTests: CDAN1
    GeneReviews: CDAN1
    Genetic Association Database (GAD): CDAN1

    Export disorders for CDAN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDAN1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with CDAN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PubMed id 12434312)1, 2, 3, 9 Dgany O.... Tamary H. (2002)
    2. Codanin-1, mutated in the anaemic disease CDAI, regula tes Asf1 function in S-phase histone supply. (PubMed id 22407294)1, 2 Ask K....Groth A. (2012)
    3. Codanin-1 mutations in congenital dyserythropoietic a nemia type 1 affect HP1{alpha} localization in erythroblasts. (PubMed id 21364188)1, 2 Renella R....Wood W.G. (2011)
    4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. (PubMed id 8634422)1, 3 Tamary H....Zaizov R. (1996)
    8. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PubMed id 19336738)1, 9 Noy-Lotan S....Tamary H. (2009)
    9. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PubMed id 18081704)1, 9 Tamary H....Delaunay J. (2008)
    10. Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. (PubMed id 16767397)1, 9 Goede J.S....Heimpel H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146059 HGNC: 1713 AceView: CDAN1 Ensembl:ENSG00000140326 euGenes: HUgn146059
    ECgene: CDAN1 H-InvDB: CDAN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDAN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDAN1 gene:
    Search GeneIP for patents involving CDAN1

    Licensable Technologies for CDAN1 gene:
    Weizmann Institute:A Novel Erythrocyte Differentiation Factor
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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