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Aliases for CDAN1 Gene

Aliases for CDAN1 Gene

  • Codanin 1 2 3 5
  • Congenital Dyserythropoietic Anemia, Type I 2 3
  • Discs Lost Homolog 3
  • Codanin-1 3
  • PRO1295 3
  • CDAN1A 3
  • CDA1 3
  • CDAI 3
  • DLT 3

External Ids for CDAN1 Gene

Previous GeneCards Identifiers for CDAN1 Gene

  • GC15U990007
  • GC15M035911
  • GC15M040594
  • GC15M040731
  • GC15M040803
  • GC15M043015
  • GC15M019864

Summaries for CDAN1 Gene

Entrez Gene Summary for CDAN1 Gene

  • This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

GeneCards Summary for CDAN1 Gene

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Dyserythropoietic Anemia, Congenital, Type Ia and Congenital Dyserythropoietic Anemia.

UniProtKB/Swiss-Prot for CDAN1 Gene

  • May act as a negative regulator of ASF1 in chromatin assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDAN1 Gene

Genomics for CDAN1 Gene

Regulatory Elements for CDAN1 Gene

Enhancers for CDAN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F042574 1.1 ENCODE 28.8 +161.6 161639 2.2 HDGF ATF1 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 CDAN1 ENSG00000260814 ZSCAN29 LRRC57 LCMT2 TP53BP1 LOC105370795 RPS3AP47 ADAL MYL12BP1
GH15F041913 1.3 Ensembl ENCODE 20.3 +819.5 819456 8.9 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SPTBN5 CDAN1 LOC105370792 ENSG00000260814 EHD4 PLA2G4E-AS1 MAPKBP1 TYRO3 RPAP1 LOC105370795
GH15F042056 1.7 FANTOM5 Ensembl ENCODE 11.9 +679.6 679561 2.0 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 GLIS2 ZNF143 FOS CDAN1 MAPKBP1 PLA2G4D PLA2G4E ENSG00000260814 LRRC57 EHD4 MGA SNAP23 TMEM87A
GH15F042497 0.9 ENCODE 19.8 +237.6 237612 4.3 HDGF HDAC1 PKNOX1 ARNT CREB3L1 FEZF1 ZBTB40 GTF3C2 POLR3A ZNF366 LRRC57 TUBGCP4 GANC LCMT2 CDAN1 HAUS2 ENSG00000260814 LOC105370795 RPAP1 RPS3AP47
GH15F041979 1.4 Ensembl ENCODE 10.6 +756.6 756613 2.4 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RPAP1 CDAN1 PLA2G4E-AS1 GC15P041980
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDAN1 on UCSC Golden Path with GeneCards custom track

Promoters for CDAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000406992 219 2001 ARNT KLF17 ARID4B SIN3A RAD21 CHAMP1 ZNF121 GLIS2 ZNF207 RCOR1

Genomic Location for CDAN1 Gene

Chromosome:
15
Start:
42,723,557 bp from pter
End:
42,737,219 bp from pter
Size:
13,663 bases
Orientation:
Minus strand

Genomic View for CDAN1 Gene

Genes around CDAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDAN1 Gene

Proteins for CDAN1 Gene

  • Protein details for CDAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWY9-CDAN1_HUMAN
    Recommended name:
    Codanin-1
    Protein Accession:
    Q8IWY9
    Secondary Accessions:
    • Q6NYD0
    • Q7Z7L5
    • Q969N3

    Protein attributes for CDAN1 Gene

    Size:
    1227 amino acids
    Molecular mass:
    134120 Da
    Quaternary structure:
    • Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88832.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDAN1 Gene

Post-translational modifications for CDAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDAN1 Gene

No data available for DME Specific Peptides for CDAN1 Gene

Domains & Families for CDAN1 Gene

Protein Domains for CDAN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDAN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDAN1 Gene

Function for CDAN1 Gene

Molecular function for CDAN1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of ASF1 in chromatin assembly.

Gene Ontology (GO) - Molecular Function for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22407294
genes like me logo Genes that share ontologies with CDAN1: view
genes like me logo Genes that share phenotypes with CDAN1: view

Human Phenotype Ontology for CDAN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDAN1 Gene

MGI Knock Outs for CDAN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDAN1

miRNA for CDAN1 Gene

miRTarBase miRNAs that target CDAN1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDAN1 Gene

Localization for CDAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDAN1 Gene

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDAN1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21364188
GO:0005737 cytoplasm IEA,IDA 22407294
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IDA 21364188
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDAN1: view

Pathways & Interactions for CDAN1 Gene

SuperPathways for CDAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IMP 21364188
GO:0008104 protein localization IMP 21364188
GO:0008156 negative regulation of DNA replication IMP 22407294
GO:0031497 chromatin assembly IMP 22407294
genes like me logo Genes that share ontologies with CDAN1: view

No data available for Pathways by source and SIGNOR curated interactions for CDAN1 Gene

Drugs & Compounds for CDAN1 Gene

(1) Drugs for CDAN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDAN1: view

Transcripts for CDAN1 Gene

Unigene Clusters for CDAN1 Gene

Codanin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CDAN1 Gene

GeneLoc Exon Structure for
CDAN1
ECgene alternative splicing isoforms for
CDAN1

Expression for CDAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDAN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.5), Adipocyte (18.2), Peripheral blood mononuclear cells (12.8), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDAN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDAN1 Gene:

CDAN1

SOURCE GeneReport for Unigene cluster for CDAN1 Gene:

Hs.599232

mRNA Expression by UniProt/SwissProt for CDAN1 Gene:

Q8IWY9-CDAN1_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
genes like me logo Genes that share expression patterns with CDAN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDAN1 Gene

Orthologs for CDAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDAN1 34 35
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia CDAN1 34 35
  • 88.4 (n)
dog
(Canis familiaris)
Mammalia CDAN1 34 35
  • 87.28 (n)
mouse
(Mus musculus)
Mammalia Cdan1 34 16 35
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Cdan1 34
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia CDAN1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDAN1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDAN1 34 35
  • 62.79 (n)
lizard
(Anolis carolinensis)
Reptilia CDAN1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdan1 34
  • 58.58 (n)
zebrafish
(Danio rerio)
Actinopterygii cdan1 34 35
  • 55.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010055 34
  • 42.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta dlt 34 35
  • 40.96 (n)
Species where no ortholog for CDAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDAN1 Gene

ENSEMBL:
Gene Tree for CDAN1 (if available)
TreeFam:
Gene Tree for CDAN1 (if available)

Paralogs for CDAN1 Gene

No data available for Paralogs for CDAN1 Gene

Variants for CDAN1 Gene

Sequence variations from dbSNP and Humsavar for CDAN1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs120074166 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120], Pathogenic 42,731,275(-) GCTCA(A/G)TGGTC nc-transcript-variant, reference, missense
rs120074167 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120], Pathogenic 42,730,757(-) CCCTC(C/T)GGTCC nc-transcript-variant, reference, missense
rs120074168 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120], Pathogenic 42,729,066(-) TAGAG(A/T)TCGTG nc-transcript-variant, reference, missense
rs370895637 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120] 42,729,063(+) TGCCA(C/T)GAACT nc-transcript-variant, reference, missense
rs80338696 Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120], Pathogenic 42,730,632(-) ATTAC(C/T)GGGAC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDAN1 Gene

Variant ID Type Subtype PubMed ID
nsv457122 CNV loss 19166990
nsv517553 CNV gain+loss 19592680
nsv528725 CNV gain 19592680
nsv569238 CNV loss 21841781
nsv952615 CNV deletion 24416366

Variation tolerance for CDAN1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.08; 99.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDAN1 Gene

Human Gene Mutation Database (HGMD)
CDAN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDAN1 Gene

Disorders for CDAN1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDAN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type ia
  • congenital dyserythropoietic anemia type i
congenital dyserythropoietic anemia
  • congenital dyshaematopoietic anaemia
angioid streaks
macrocytic anemia
  • anemia macrocytic
acrodysostosis
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search CDAN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDAN1_HUMAN
  • Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120]: An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. {ECO:0000269 PubMed:12434312}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDAN1

Genetic Association Database (GAD)
CDAN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDAN1
genes like me logo Genes that share disorders with CDAN1: view

No data available for Genatlas for CDAN1 Gene

Publications for CDAN1 Gene

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PMID: 12434312) Dgany O. … Tamary H. (Am. J. Hum. Genet. 2002) 2 3 4 22 64
  2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K. … Groth A. (EMBO J. 2012) 3 4 64
  3. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1-alpha localization in erythroblasts. (PMID: 21364188) Renella R. … Wood W.G. (Blood 2011) 3 4 64
  4. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PMID: 19336738) Noy-Lotan S. … Tamary H. (Haematologica 2009) 3 22 64
  5. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PMID: 18081704) Tamary H. … Delaunay J. (Eur. J. Haematol. 2008) 3 22 64

Products for CDAN1 Gene

Sources for CDAN1 Gene

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