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Aliases for CDAN1 Gene

Aliases for CDAN1 Gene

  • Codanin 1 2 3
  • Congenital Dyserythropoietic Anemia, Type I 2 3
  • CDAN1A 3 6
  • CDA1 3 6
  • Discs Lost Homolog 3
  • Codanin-1 3
  • PRO1295 3
  • CDAI 3
  • DLT 3

External Ids for CDAN1 Gene

Summaries for CDAN1 Gene

Entrez Gene Summary for CDAN1 Gene

  • This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

GeneCards Summary for CDAN1 Gene

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include dyserythropoietic anemia, congenital, type ia and congenital dyserythropoietic anemia.

UniProtKB/Swiss-Prot for CDAN1 Gene

  • May acts as a negative regulator of ASF1 in chromatin assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDAN1 Gene

Genomics for CDAN1 Gene

Genomic Location for CDAN1 Gene

Start:
42,723,559 bp from pter
End:
42,737,219 bp from pter
Size:
13,661 bases
Orientation:
Minus strand

Genomic View for CDAN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDAN1 Gene

Regulatory Elements for CDAN1 Gene

Proteins for CDAN1 Gene

  • Protein details for CDAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWY9-CDAN1_HUMAN
    Recommended name:
    Codanin-1
    Protein Accession:
    Q8IWY9
    Secondary Accessions:
    • Q6NYD0
    • Q7Z7L5
    • Q969N3

    Protein attributes for CDAN1 Gene

    Size:
    1227 amino acids
    Molecular mass:
    134120 Da
    Quaternary structure:
    • Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88832.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDAN1 Gene

Proteomics data for CDAN1 Gene at MOPED

Post-translational modifications for CDAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDAN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDAN1 Gene

Domains for CDAN1 Gene

Protein Domains for CDAN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDAN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDAN1 Gene

Function for CDAN1 Gene

Molecular function for CDAN1 Gene

UniProtKB/Swiss-Prot Function: May acts as a negative regulator of ASF1 in chromatin assembly.

Gene Ontology (GO) - Molecular Function for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22407294
genes like me logo Genes that share ontologies with CDAN1: view

Phenotypes for CDAN1 Gene

MGI mutant phenotypes for CDAN1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CDAN1:
genes like me logo Genes that share phenotypes with CDAN1: view

miRNA for CDAN1 Gene

miRTarBase miRNAs that target CDAN1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDAN1 Gene

Localization for CDAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDAN1 Gene

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDAN1 Gene COMPARTMENTS Subcellular localization image for CDAN1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21364188
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IDA 21364188
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDAN1: view

Pathways for CDAN1 Gene

SuperPathways for CDAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IMP 21364188
GO:0008104 protein localization IMP 21364188
GO:0008156 negative regulation of DNA replication IMP 22407294
GO:0031497 chromatin assembly IMP 22407294
genes like me logo Genes that share ontologies with CDAN1: view

No data available for Pathways by source for CDAN1 Gene

Compounds for CDAN1 Gene

(1) Novoseek inferred chemical compound relationships for CDAN1 Gene

Compound -log(P) Hits PubMed IDs
iron 16.7 1
genes like me logo Genes that share compounds with CDAN1: view

Transcripts for CDAN1 Gene

Unigene Clusters for CDAN1 Gene

Codanin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CDAN1 Gene

GeneLoc Exon Structure for
CDAN1
ECgene alternative splicing isoforms for
CDAN1

Expression for CDAN1 Gene

mRNA expression in normal human tissues for CDAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDAN1 Gene

SOURCE GeneReport for Unigene cluster for CDAN1 Gene Hs.599232

mRNA Expression by UniProt/SwissProt for CDAN1 Gene

Q8IWY9-CDAN1_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
genes like me logo Genes that share expressions with CDAN1: view

No data available for mRNA differential expression in normal tissues for CDAN1 Gene

Orthologs for CDAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDAN1 35
  • 99.27 (n)
  • 98.81 (a)
CDAN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDAN1 35
  • 88.4 (n)
  • 88.35 (a)
CDAN1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDAN1 35
  • 87.28 (n)
  • 87.4 (a)
CDAN1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdan1 35
  • 86.62 (n)
  • 88.74 (a)
Cdan1 16
Cdan1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDAN1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDAN1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdan1 35
  • 86.19 (n)
  • 88.82 (a)
chicken
(Gallus gallus)
Aves CDAN1 35
  • 62.79 (n)
  • 59.98 (a)
CDAN1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDAN1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdan1 35
  • 58.58 (n)
  • 55.51 (a)
zebrafish
(Danio rerio)
Actinopterygii cdan1 35
  • 55.09 (n)
  • 49.69 (a)
cdan1 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010055 35
  • 42.14 (n)
  • 29.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta dlt 35
  • 40.96 (n)
  • 29.65 (a)
dlt 36
  • 21 (a)
OneToOne
Species with no ortholog for CDAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDAN1 Gene

ENSEMBL:
Gene Tree for CDAN1 (if available)
TreeFam:
Gene Tree for CDAN1 (if available)

Paralogs for CDAN1 Gene

No data available for Paralogs for CDAN1 Gene

Variants for CDAN1 Gene

Sequence variations from dbSNP and Humsavar for CDAN1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2305084 -- 42,726,493(-) GGCTG(A/C)TCCCT intron-variant
rs2305085 -- 42,726,288(-) GCCAC(C/T)GGGGG intron-variant, downstream-variant-500B
rs3742987 -- 42,724,349(-) GTGTC(A/G)CTGCC utr-variant-3-prime
rs3742988 -- 42,724,277(-) AAAAG(C/T)CCAGA utr-variant-3-prime
rs4265781 Benign, - 42,736,551(+) TGCTC(A/T)GGGCC reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CDAN1 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV Gain 19592680
nsv457122 CNV Loss 19166990
nsv517553 CNV Gain+Loss 19592680

Relevant External Links for CDAN1 Gene

HapMap Linkage Disequilibrium report
CDAN1
Human Gene Mutation Database (HGMD)
CDAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDAN1 Gene

Disorders for CDAN1 Gene

(1) OMIM Diseases for CDAN1 Gene (607465)

UniProtKB/Swiss-Prot

CDAN1_HUMAN
  • Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120]: An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. {ECO:0000269 PubMed:12434312}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CDAN1 Gene

(2) Novoseek inferred disease relationships for CDAN1 Gene

Disease -log(P) Hits PubMed IDs
cda i 99.1 11
anemia 43.5 1

Relevant External Links for CDAN1

GeneTests
CDAN1
GeneReviews
CDAN1
Genetic Association Database (GAD)
CDAN1
genes like me logo Genes that share disorders with CDAN1: view

Publications for CDAN1 Gene

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PMID: 12434312) Dgany O. … Tamary H. (Am. J. Hum. Genet. 2002) 2 3 4 23
  2. Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. (PMID: 16767397) Goede J.S. … Heimpel H. (Ann. Hematol. 2006) 3 23
  3. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PMID: 18081704) Tamary H. … Delaunay J. (Eur. J. Haematol. 2008) 3 23
  4. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PMID: 19336738) Noy-Lotan S. … Tamary H. (Haematologica 2009) 3 23
  5. Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. (PMID: 8634422) Tamary H. … Zaizov R. (Blood 1996) 2 3

Products for CDAN1 Gene

Sources for CDAN1 Gene

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