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CDA Gene

protein-coding   GIFtS: 67
GCID: GC01P020915

Cytidine Deaminase

  See CDA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytidine Deaminase1 2
Cytidine Aminohydrolase2 3
CDD2 3
Cytosine Nucleoside Deaminase2
Small Cytidine Deaminase2
EC 3.5.4.53

External Ids:    HGNC: 17121   Entrez Gene: 9782   Ensembl: ENSG000001588257   OMIM: 1239205   UniProtKB: P323203   

Export aliases for CDA gene to outside databases

Previous GC identifers: GC01P020485 GC01P019951 GC01P020061 GC01P020385 GC01P020660 GC01P020788 GC01P019161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDA Gene:
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that
catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine,
respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations
in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside
used in the treatment of certain childhood leukemias. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDA Gene:
CDA (cytidine deaminase) is a protein-coding gene. Diseases associated with CDA include xeroderma pigmentosum, group d. GO annotations related to this gene include protein homodimerization activity and nucleoside binding.

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320
Function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Gene Wiki entry for CDA (Cytidine deaminase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDA gene promoter:
         COUP-TF1   Pax-5   AP-1   ATF-2   COUP   Nkx2-5   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDA promoter sequence
   Search Chromatin IP Primers for CDA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2-p35   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.2-p35

CDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P020915:  view genomic region     (about GC identifiers)

Start:
20,915,441 bp from pter      End:
20,945,401 bp from pter
Size:
29,961 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDD_HUMAN, P32320 (See protein sequence)
Recommended Name: Cytidine deaminase  
Size: 146 amino acids; 16185 Da
Cofactor: Zinc
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for CDA:
1MQ0 (3D)    

Explore the universe of human proteins at neXtProt for CDA: NX_P32320

Explore proteomics data for CDA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001776.1  
    ENSEMBL proteins: 
     ENSP00000364212  
    Reactome Protein details: P32320

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    antibodies-online peptides for CDA

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR002125 CMP_dCMP_Zn-bd
     IPR016193 Cytidine_deaminase-like
     IPR006262 Cyt_deam_tetra

    Graphical View of Domain Structure for InterPro Entry P32320

    ProtoNet protein and cluster: P32320

    1 Blocks protein domain: IPB002125 Cytidine/deoxycytidylate deaminase

    UniProtKB/Swiss-Prot: CDD_HUMAN, P32320
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 1 CMP/dCMP deaminase zinc-binding domain


    Find genes that share domains with CDA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDD_HUMAN, P32320
    Function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
    Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
    Catalytic activity: 2'deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3)

         Genatlas biochemistry entry for CDA:
    cytidine deaminase,pyrimidine catabolic pathway

         Enzyme Number (IUBMB): EC 3.5.4.51

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001882nucleoside binding IDA15689149
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity IDA7923172
    GO:0008270zinc ion binding TAS9596658
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with CDA           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDA

    miRNA
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    miRTarBase miRNAs that target CDA:
    hsa-mir-335-5p (MIRT018180)

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    4 qRT-PCR Assays for microRNAs that regulate CDA:
    hsa-miR-1265 hsa-miR-374b hsa-miR-374a hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCDA 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS9596658
    GO:0005829cytosol TAS9596658

    Find genes that share ontologies with CDA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDA About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Pyrimidine metabolism0.33
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    Pyrimidine salvage reactions0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine ribonucleosides degradation
    superpathway of pyrimidine ribonucleosides degradation0.60
    pyrimidine ribonucleosides degradation0.00
    pyrimidine deoxyribonucleosides degradation0.33
    4superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleosides salvage0.00
    5Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42


    Find genes that share SuperPaths with CDA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for CDA (see all 7)
        Fluoropyrimidine Activity
    pyrimidine ribonucleosides degradation
    pyrimidine deoxyribonucleosides degradation
    pyrimidine deoxyribonucleosides salvage
    pyrimidine ribonucleosides salvage I


    1 Reactome Pathway for CDA
        Pyrimidine salvage reactions

    2 PharmGKB Pathways for CDA
        Fluoropyrimidine Pathway, Pharmacokinetics
    Gemcitabine Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CDA):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDA
    Interactions:

        GeneGlobe Interaction Network for CDA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDA (P323203 ENSP000003642124) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2HP524343, ENSP000002962234I2D: score=5 STRING: ENSP00000296223
    SDHBP219123, ENSP000003646494I2D: score=5 STRING: ENSP00000364649
    CCDC130P139943, ENSP000002215544I2D: score=1 STRING: ENSP00000221554
    KPNA2P522923, ENSP000003324554I2D: score=1 STRING: ENSP00000332455
    EIF2B2P497703, ENSP000002661264I2D: score=6 STRING: ENSP00000266126
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0007166cell surface receptor signaling pathway NAS9596658
    GO:0008655pyrimidine-containing compound salvage NAS9596658
    GO:0009972cytidine deamination IDA9596658
    GO:0019858cytosine metabolic process TAS7923172

    Find genes that share ontologies with CDA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CDA (CDD)

    7 HMDB Compounds for CDA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Uridine1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)58-96-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--

    5 DrugBank Compounds for CDA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Capecitabine-- 154361-50-9enzymesubstrate11291832 12866042 10630095 11587492 11081570
    GemcitabinedFdC (see all 4)95058-81-4enzymesubstrate18600531 21284703 19514966
    CytarabineAra-C (see all 26)147-94-4enzymesubstrate19842938 15492802
    Azacitidine5 AZC (see all 4)320-67-2enzymesubstrate18548103
    1-Beta-Ribofuranosyl-1,3-Diazepinone-- --target----
    enzyme----

    Selected Novoseek inferred chemical compound relationships for CDA gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 94.8 63 17194903 (2), 15492802 (2), 15713780 (2), 20010457 (2) (see all 53)
    deoxycytidine 89.9 22 11705877 (3), 17296311 (2), 15492802 (2), 16585222 (1) (see all 15)
    tetrahydrouridine 89.2 9 17296311 (1), 18562256 (1), 20043109 (1)
    gemcitabine 80.4 53 19933910 (6), 17194903 (5), 12477049 (5), 20010457 (4) (see all 16)
    cytarabine 68.4 12 15492802 (3), 14744791 (2), 11320667 (2), 19035178 (1) (see all 7)
    ara-ctp 67.3 1 14744791 (1)
    nucleoside 61.7 5 16585222 (1), 17296311 (1), 10499616 (1), 17094807 (1) (see all 5)
    dctp 59.9 2 8494545 (1)
    2-chlorodeoxyadenosine 45.5 4 10499616 (1), 11705877 (1)
    pyrimidine 38.6 3 15147186 (1), 18058532 (1), 12406912 (1)

    3 PharmGKB related drug/compound annotations for CDA gene    About this table
    Drug/compound PharmGKB Annotation
    capecitabineCA  
    cytarabineCA  
    gemcitabineCA  



    Find genes that share compounds with CDA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDA gene: 
    NM_001785.2  

    Unigene Cluster for CDA:

    Cytidine deaminase
    Hs.466910  [show with all ESTs]
    Unigene Representative Sequence: BC048284
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375071(uc001bdk.3 uc001bdl.3 uc009vpv.3) ENST00000461985

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    Additional mRNA sequence: 

    AJ000474.1 AY634312.2 BC048284.1 BC054036.1 L27943.1 S52873.1 

    6 DOTS entries:

    DT.100754460  DT.409450  DT.95165565  DT.99985347  DT.91760241  DT.91793087 

    Selected AceView cDNA sequences (see all 74):

    CB108404 AV647934 BM557701 BF149259 AV649418 BU734921 CD675458 AW950272 
    BM705637 BM045500 BU595610 CB109454 BG220199 AI690499 S52873 AJ000474 
    BC054036 BQ447414 BF724965 BM043370 BM762918 T28016 AV649252 AV660660 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDA (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                                  -                                 
    SP2:                                                  -                                 
    SP3:                                      -           -                                 
    SP4:                                      -                                             
    SP5:                                      -           -     -                           


    ECgene alternative splicing isoforms for CDA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGTCCAGG
    CDA Expression
    About this image


    CDA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    CDA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466910

    UniProtKB/Swiss-Prot: CDD_HUMAN, P32320
    Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes,
    monocytes, and T- as well as B-cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDA gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cda1 , 5 cytidine deaminase1, 5 83.79(n)1
    81.51(a)1
      4 (70.17 cM)5
    722691  NM_028176.11  NP_082452.11 
     1383384245 
    chicken
    (Gallus gallus)
    Aves CDA1 cytidine deaminase 73.79(n)
    74.05(a)
      771849  NM_001146044.1  NP_001139516.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDA6
    cytidine deaminase
    63(a)
    1 ↔ 1
    AAWZ02039226(1244-1757)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.93652 Transcribed sequence with weak similarity to protein more 77.57(n)    137696278 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.162082 Transcribed sequence with weak similarity to protein more 76.85(n)    CD598599.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83606
    CG83536
    (see all 3)
    --
    40(a)
    37(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    2L(8212959-8214135)
    2L(8214045-8215239)
    worm
    (Caenorhabditis elegans)
    Secernentea cdd-26
    cdd-16
    Protein CDD-1 (cdd-1) mRNA, complete cds
    38(a)
    34(a)
    many → 1
    many → 1
    IV(7547118-7547893) WBGene00000392
    X(8208751-8211149) WBGene00000391
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDD1(YLR245C)4
    CDD11
    Cytidine deaminase; catalyzes the modification of cytidine more4
    CDD11
    51.88(n)1
    44.35(a)1
      12(626930-626502)4
    8509461, 4  NP_013346.11, 4 


    ENSEMBL Gene Tree for CDA (if available)
    TreeFam Gene Tree for CDA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDA (see all 755)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358069561,2
    C--19184827(+) TGCAA-/TTTTTT 1 -- int10--------
    rs12539041,2
    C,F,O,A--20913519(-) CATACA/GTGAGG 1 -- us2k118Minor allele frequency- N:0.00EA NA NS CSA 1243
    rs1870789181,2
    --20913529(+) GACCAA/CGTGCA 1 -- us2k10--------
    rs1915224391,2
    --20913530(+) ACCACA/GTGCAG 1 -- us2k10--------
    rs120459761,2
    C--20913609(+) TGGAGA/TCAAGG 1 -- us2k10--------
    rs781339361,2
    C--20913612(+) AGTCAA/GGGAGT 1 -- us2k10--------
    rs2016563531,2
    --20913614(+) CAAGG-/CAGTCC 1 -- us2k10--------
    rs1163209601,2
    F--20913679(+) AGGGGA/GCAGGA 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1472202631,2
    C--20913803(+) TTGAGC/TGGGCA 1 -- us2k10--------
    rs1836365731,2
    --20913891(+) AAAGTA/GCATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDA (20915441 - 20945401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CDA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998962CNV Deletion20482838
    esv2662052CNV Deletion23128226
    esv2667482CNV Deletion23128226
    esv2744975CNV Deletion23290073
    esv270154CNV Insertion20981092
    nsv834369CNV Loss17160897
    nsv511682CNV Loss21212237
    esv24339CNV Loss19812545
    nsv528156CNV Loss19592680
    nsv460729CNV Gain19166990

    Human Gene Mutation Database (HGMD): CDA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDA
    DNA2.0 Custom Variant and Variant Library Synthesis for CDA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123920    OMIM disorders: --

    1 disease for CDA:    
    About MalaCards
    xeroderma pigmentosum, group d

    1 disease from the University of Copenhagen DISEASES database for CDA:
    Leukemia

    Find genes that share disorders with CDA           About GenesLikeMe

    10 Novoseek inferred disease relationships for CDA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute leukemia 44.1 3 19035178 (1), 18067088 (1), 16446974 (1)
    leukemia 36 9 11320667 (3), 19099730 (2), 15492802 (1), 11705877 (1) (see all 5)
    solid tumor 34.9 2 11320667 (1)
    hematologic malignancies 31.4 1 19099730 (1)
    lymphoblastic leukemia acute 26.7 1 10499616 (1)
    cancer 15.6 7 15814642 (2), 17194903 (1), 17885621 (1), 8494545 (1) (see all 6)
    nsclc 6.6 1 20211060 (2), 18347182 (2), 19500405 (1), 20213492 (1)
    carcinoma 0.3 5 15492802 (4), 15867251 (1)
    cancer lung 0 1 20213492 (1)
    tumors 0 4 16585222 (2), 12477049 (1)

    Genetic Association Database (GAD): CDA
    Human Genome Epidemiology (HuGE) Navigator: CDA (28 documents)

    Export disorders for CDA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDA gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with CDA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. (PubMed id 18600531)1, 4, 7, 9 Giovannetti E....Peters G.J. (amp 2008)
    2. Isolation and characterization of the gene coding for human cytidine deaminase. (PubMed id 9878810)1, 2, 3 Demontis S....Garattini E. (Biochim. Biophys. Acta 1998)
    3. Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. (PubMed id 8422236)1, 2, 3 Kuhn K.... Emmrich F. (Biochem. Biophys. Res. Commun. 1993)
    4. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. (PubMed id 17194903)1, 4, 9 Sugiyama E....Saijo N. (J. Clin. Oncol. 2007)
    5. [Study on the relationship between human cytidine deaminase gene polymorphisms and Ara-C sensitivity]. (PubMed id 19035178)1, 4, 9 Chen X.W....Zhang M. (Zhonghua Xue Ye Xue Za Zhi 2008)
    6. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. (PubMed id 18347182)1, 4, 9 Tibaldi C....Danesi R. (Clin. Cancer Res. 2008)
    7. Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene. (PubMed id 20045991)1, 4, 9 Sugiyama E....Shin J.G. (Drug Metab. Pharmacokinet. 2009)
    8. Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A&gt;C cytidine deaminase polymorphism. (PubMed id 20213492)1, 4, 9 Maring J.G....Groen H.J. (Eur. J. Clin. Pharmacol. 2010)
    9. Structure of human cytidine deaminase bound to a potent inhibitor. (PubMed id 15689149)1, 2, 9 Chung S.J.... Verdine G.L. (J. Med. Chem. 2005)
    10. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4, 9 Okazaki T....Li D. (Clin. Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 978 HGNC: 1712 AceView: CDA Ensembl:ENSG00000158825 euGenes: HUgn978
    ECgene: CDA Kegg: 978 H-InvDB: CDA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDA gene:
    Search GeneIP for patents involving CDA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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