Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDA Gene

Aliases for CDA Gene

  • Cytidine Deaminase 2 3
  • Cytidine Aminohydrolase 3 4
  • CDD 3 4
  • Cytosine Nucleoside Deaminase 3
  • Small Cytidine Deaminase 3
  • EC 3.5.4.5 4

External Ids for CDA Gene

Previous GeneCards Identifiers for CDA Gene

  • GC01P020485
  • GC01P019951
  • GC01P020061
  • GC01P020385
  • GC01P020660
  • GC01P020788
  • GC01P020915
  • GC01P019161

Summaries for CDA Gene

Entrez Gene Summary for CDA Gene

  • This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDA Gene

CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include xeroderma pigmentosum, group d. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and nucleoside binding.

UniProtKB/Swiss-Prot for CDA Gene

  • This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis

Gene Wiki entry for CDA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDA Gene

Genomics for CDA Gene

Regulatory Elements for CDA Gene

Genomic Location for CDA Gene

Start:
20,588,948 bp from pter
End:
20,618,908 bp from pter
Size:
29,961 bases
Orientation:
Plus strand

Genomic View for CDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDA Gene

Proteins for CDA Gene

  • Protein details for CDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32320-CDD_HUMAN
    Recommended name:
    Cytidine deaminase
    Protein Accession:
    P32320
    Secondary Accessions:

    Protein attributes for CDA Gene

    Size:
    146 amino acids
    Molecular mass:
    16185 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CDA Gene

neXtProt entry for CDA Gene

Proteomics data for CDA Gene at MOPED

Post-translational modifications for CDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDA Gene

Domains for CDA Gene

Suggested Antigen Peptide Sequences for CDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32320

UniProtKB/Swiss-Prot:

CDD_HUMAN :
  • P32320
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with CDA: view

No data available for Gene Families for CDA Gene

Function for CDA Gene

Molecular function for CDA Gene

GENATLAS Biochemistry: cytidine deaminase,pyrimidine catabolic pathway
UniProtKB/Swiss-Prot CatalyticActivity: Cytidine + H(2)O = uridine + NH(3)
UniProtKB/Swiss-Prot CatalyticActivity: 2deoxycytidine + H(2)O = 2-deoxyuridine + NH(3)
UniProtKB/Swiss-Prot Function: This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis

Enzyme Numbers (IUBMB) for CDA Gene

Gene Ontology (GO) - Molecular Function for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding IDA 15689149
GO:0003824 catalytic activity --
GO:0004126 cytidine deaminase activity IDA 7923172
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding TAS 9596658
genes like me logo Genes that share ontologies with CDA: view

miRNA for CDA Gene

miRTarBase miRNAs that target CDA

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDA Gene

Localization for CDA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDA Gene COMPARTMENTS Subcellular localization image for CDA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9596658
GO:0005829 cytosol TAS 9596658
genes like me logo Genes that share ontologies with CDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDA Gene

Pathways for CDA Gene

genes like me logo Genes that share pathways with CDA: view

Gene Ontology (GO) - Biological Process for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0007166 cell surface receptor signaling pathway NAS 9596658
GO:0008655 pyrimidine-containing compound salvage NAS 9596658
GO:0009972 cytidine deamination IDA 9596658
GO:0019858 cytosine metabolic process TAS 7923172
genes like me logo Genes that share ontologies with CDA: view

Compounds for CDA Gene

(7) HMDB Compounds for CDA Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Cytidine
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
65-46-3
dCMP
  • 2'-Deoxycytidine 5'-monophosphate
1032-65-1
Deoxycytidine
  • 1-(2-Deoxy-b-D-ribofuranosyl)cytosine
951-77-9
Deoxyuridine
  • 1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
951-78-0

(6) Drugbank Compounds for CDA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-Beta-Ribofuranosyl-1,3-Diazepinone
target
1-Beta-Ribofuranosyl-1,3-Diazepinone
enzyme
Azacitidine
  • 5 AZC
320-67-2 enzyme substrate
Capecitabine
154361-50-9 enzyme substrate
Cytarabine
  • Ara-C
147-94-4 enzyme substrate

(17) Novoseek inferred chemical compound relationships for CDA Gene

Compound -log(P) Hits PubMed IDs
cytidine 94.8 58
deoxycytidine 89.9 19
tetrahydrouridine 89.2 3
gemcitabine 80.4 44
cytarabine 68.4 11

(3) PharmGKB related drug/compound annotations for CDA Gene

Drug/compound Annotation
capecitabine CA
cytarabine CA
gemcitabine CA
genes like me logo Genes that share compounds with CDA: view

Transcripts for CDA Gene

mRNA/cDNA for CDA Gene

Unigene Clusters for CDA Gene

Cytidine deaminase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDA Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - -

Relevant External Links for CDA Gene

GeneLoc Exon Structure for
CDA
ECgene alternative splicing isoforms for
CDA

Expression for CDA Gene

mRNA expression in normal human tissues for CDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDA Gene

This gene is overexpressed in Whole Blood (32.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDA Gene

SOURCE GeneReport for Unigene cluster for CDA Gene Hs.466910

mRNA Expression by UniProt/SwissProt for CDA Gene

P32320-CDD_HUMAN
Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines
genes like me logo Genes that share expressions with CDA: view

Orthologs for CDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDA 35
  • 99.77 (n)
  • 100 (a)
CDA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDA 35
  • 83.56 (n)
  • 80.82 (a)
CDA 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDA 35
  • 83.11 (n)
  • 76.71 (a)
CDA 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cda 35
  • 83.79 (n)
  • 81.51 (a)
Cda 16
Cda 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDA 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909857 35
  • 82.88 (n)
  • 81.51 (a)
chicken
(Gallus gallus)
Aves CDA 35
  • 73.79 (n)
  • 74.05 (a)
CDA 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDA 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cda 35
  • 69.61 (n)
  • 68.38 (a)
Str.9365 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7726 35
zebrafish
(Danio rerio)
Actinopterygii cda 35
  • 68.99 (n)
  • 72.09 (a)
cda 36
  • 60 (a)
OneToMany
CDA (1 of 3) 36
  • 57 (a)
OneToMany
CDA (3 of 3) 36
  • 63 (a)
OneToMany
Dr.16208 35
fruit fly
(Drosophila melanogaster)
Insecta CG8349 36
  • 21 (a)
OneToMany
CG8353 36
  • 37 (a)
OneToMany
CG8360 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdd-1 36
  • 34 (a)
OneToMany
cdd-2 36
  • 38 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL123W 35
  • 52.54 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDD1 35
  • 51.88 (n)
  • 44.35 (a)
CDD1 36
  • 37 (a)
OneToOne
CDD1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18414g 35
  • 51.36 (n)
  • 47.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08359 35
  • 53.54 (n)
  • 44.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdd1 35
  • 50.39 (n)
  • 51.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for CDA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDA Gene

ENSEMBL:
Gene Tree for CDA (if available)
TreeFam:
Gene Tree for CDA (if available)

Paralogs for CDA Gene

No data available for Paralogs for CDA Gene

Variants for CDA Gene

Sequence variations from dbSNP and Humsavar for CDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs471760 -- 20,590,713(-) AATGG(C/T)ACAAA intron-variant
rs472629 -- 20,590,615(-) AAGCA(C/T)GGCAG intron-variant
rs476790 -- 20,619,002(+) TGTTC(C/G)GAGAG downstream-variant-500B
rs477155 -- 20,609,755(+) GTGAA(A/G)AATAA intron-variant
rs488991 -- 20,613,765(-) CTGAG(A/T)CTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDA Gene

Variant ID Type Subtype PubMed ID
nsv460729 CNV Gain 19166990
nsv528156 CNV Loss 19592680
esv998962 CNV Deletion 20482838
nsv511682 CNV Loss 21212237
esv2744975 CNV Deletion 23290073
esv2662052 CNV Deletion 23128226
esv24339 CNV Loss 19812545
esv2667482 CNV Deletion 23128226
nsv834369 CNV Loss 17160897
esv270154 CNV Insertion 20981092

Relevant External Links for CDA Gene

HapMap Linkage Disequilibrium report
CDA
Human Gene Mutation Database (HGMD)
CDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDA Gene

Disorders for CDA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDA Gene including...

Search for CDA Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDA Gene

(10) Novoseek inferred disease relationships for CDA Gene

Disease -log(P) Hits PubMed IDs
acute leukemia 44.1 3
leukemia 36 8
solid tumor 34.9 1
hematologic malignancies 31.4 1
lymphoblastic leukemia acute 26.7 1

Relevant External Links for CDA

Genetic Association Database (GAD)
CDA
Human Genome Epidemiology (HuGE) Navigator
CDA
genes like me logo Genes that share disorders with CDA: view

No data available for UniProtKB/Swiss-Prot for CDA Gene

Publications for CDA Gene

  1. Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. (PMID: 18600531) Giovannetti E. … Peters G.J. (Nucleosides Nucleotides Nucleic Acids 2008) 3 23 25 48
  2. Structure of human cytidine deaminase bound to a potent inhibitor. (PMID: 15689149) Chung S.J. … Verdine G.L. (J. Med. Chem. 2005) 3 4 23
  3. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. (PMID: 17194903) Sugiyama E. … Saijo N. (J. Clin. Oncol. 2007) 3 23 48
  4. [Study on the relationship between human cytidine deaminase gene polymorphisms and Ara-C sensitivity]. (PMID: 19035178) Chen X.W. … Zhang M. (Zhonghua Xue Ye Xue Za Zhi 2008) 3 23 48
  5. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. (PMID: 18347182) Tibaldi C. … Danesi R. (Clin. Cancer Res. 2008) 3 23 48

Products for CDA Gene

Sources for CDA Gene

Back to Top

Content