Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDA Gene

protein-coding GIFtS: 65
GCID: GC01P020915

cytidine deaminase

Explore 30 diseases affiliated with
CDA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytidine Deaminase¹ ²
CDD¹ ² ³
Cytidine Aminohydrolase² ³
Cytosine Nucleoside Deaminase²
Small Cytidine Deaminase²
EC 3.5.4.5³

External Ids:	HGNC: 1712¹	Entrez Gene: 978²	Ensembl: ENSG00000158825⁷	OMIM: 123920⁵	UniProtKB: P32320³

Export aliases for CDA gene to outside databases

Previous GC identifers: GC01P020485 GC01P019951 GC01P020061 GC01P020385 GC01P020660 GC01P020788 GC01P019161

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDA:

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes

the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is

one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are

associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment

of certain childhood leukemias. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320

Function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Gene Wiki entry for CDA (Cytidine deaminase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDA gene promoter:
COUP-TF1 Pax-5 AP-1 ATF-2 COUP Nkx2-5 HNF-4alpha2 HNF-4alpha1 COUP-TF c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDA promoter sequence

Search SABiosciences Chromatin IP Primers for CDA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2-p35 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.2-p35

CDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDA gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P020915: view genomic region (about GC identifiers)

Start:	20,915,441 bp from pter	End:	20,945,401 bp from pter
Size:	29,961 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320 (See protein sequence)

Recommended Name: Cytidine deaminase

Size: 146 amino acids; 16185 Da

Cofactor: Zinc

Subunit: Homotetramer

1 PDB 3D structure from and Proteopedia for CDA:

1MQ0 (3D)

Explore the universe of human proteins at neXtProt for CDA: NX_P32320

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P32320

CDA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001776.1

ENSEMBL proteins:

ENSP00000364212

Reactome Protein details: P32320
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CDA OriGene Custom Protein Services for CDA
	GenScript Custom Purified and Recombinant Proteins Services for CDA
	Novus Biologicals CDA Proteins Novus Biologicals CDA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CDA
	Uscn Proteins for CDA

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	9596658
GO:0005829	cytosol	TAS	--

CDA for ontologies About GeneDecksing

CDA Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CDA
	GenScript Custom Superior Antibodies Services for CDA
	Novus Biologicals CDA Antibodies
	Abcam antibodies for CDA
	Uscn Antibodies for CDA
	ThermoFisher Antibodies for CDA

Assay Products for CDA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDA for domains About GeneDecksing

4 InterPro domains/families:

IPR016192 APOBEC/CMP_deaminase_Zn-bd

IPR002125 CMP_dCMP_Zn-bd

IPR016193 Cytidine_deaminase-like

IPR006262 Cyt_deam_tetra

Graphical View of Domain Structure for InterPro Entry P32320

ProtoNet protein and cluster: P32320

1 Blocks protein family: IPB002125 Cytidine/deoxycytidylate deaminase

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family

Similarity: Contains 1 CMP/dCMP deaminase zinc-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320

Function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Catalytic activity: Cytidine + H(2)O = uridine + NH(3)

Genatlas biochemistry entry for CDA:

cytidine deaminase,pyrimidine catabolic pathway

Enzyme Number (IUBMB): EC 3.5.4.5¹

miRNA Products:		OriGene 3'-UTR Clone: CDA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CDA:
		hsa-miR-1265 hsa-miR-374b hsa-miR-374a hsa-miR-3657
		SwitchGear 3'UTR luciferase reporter plasmid: CDA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDA (see all 7) OriGene shRNA RFP: CDA OriGene siRNA: CDA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CDA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDA (NM_001785)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDA
		Search LifeMap BioReagents cell lines for CDA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001882	nucleoside binding	IDA	15689149
GO:0004126	cytidine deaminase activity	IDA	7923172
GO:0008270	zinc ion binding	TAS	9596658
GO:0042802	identical protein binding	--	--
GO:0042803	protein homodimerization activity	IDA	15689149

CDA for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pyrimidine metabolism

	Pyrimidine metabolism	1.00			salvage pathways of pyrimidine deoxyribonucleotides	0.15
	Pyrimidine salvage reactions	0.38

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Fluoropyrimidine Activity

Fluoropyrimidine Activity

1.00

Fluoropyrimidine Pathway, Pharmacokinetics

0.73

Gemcitabine Pathway, Pharmacodynamics

Gemcitabine Pathway, Pharmacodynamics

1.00

pyrimidine ribonucleotides interconversion

salvage pathways of pyrimidine ribonucleotides

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for CDA

	Fluoropyrimidine Activity
	salvage pathways of pyrimidine ribonucleotides
	salvage pathways of pyrimidine deoxyribonucleotides

4 Reactome Pathways for CDA

	Metabolism of nucleotides
	Metabolism
	Pyrimidine salvage reactions
	Pyrimidine metabolism

2 PharmGKB Pathways for CDA

	Fluoropyrimidine Pathway, Pharmacokinetics
	Gemcitabine Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for CDA):

	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

CDA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for CDA (P32320³ ENSP00000364212⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLR2H	P52434³, ENSP00000296223⁴	I2D: score=5 STRING: ENSP00000296223
SDHB	P21912³, ENSP00000364649⁴	I2D: score=5 STRING: ENSP00000364649
NTMT1	Q9BV86³, ENSP00000361558⁴	I2D: score=2 STRING: ENSP00000361558
COQ2	Q96H96³, ENSP00000409275⁴	I2D: score=1 STRING: ENSP00000409275
GCLC	P48506³, ENSP00000229416⁴	I2D: score=1 STRING: ENSP00000229416

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006206	pyrimidine nucleobase metabolic process	TAS	--
GO:0007166	cell surface receptor signaling pathway	NAS	9596658
GO:0008655	pyrimidine-containing compound salvage	NAS	9596658
GO:0009972	cytidine deamination	IDA	9596658
GO:0019858	cytosine metabolic process	TAS	7923172

CDA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDA

7 HMDB Compounds for CDA About this table

Compound	Synonyms	CAS #	PubMed Ids
Ammonia	NH3 (see all 31)	7664-41-7	--
Cytidine	1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)	65-46-3	--
Deoxycytidine	1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)	951-77-9	--
Deoxyuridine	1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)	951-78-0	--
Uridine	1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)	58-96-8	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--
dCMP	2'-Deoxycytidine 5'-monophosphate (see all 12)	1032-65-1	--

5 DrugBank Compounds for CDA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Capecitabine	--	154361-50-9	enzyme	substrate	11291832 12866042 10630095 11587492 11081570
Gemcitabine	--	95058-81-4	enzyme	substrate	18600531 21284703 19514966
Cytarabine	Ara-C (see all 26)	147-94-4	enzyme	substrate	19842938 15492802
Azacitidine	5 AZC (see all 4)	320-67-2	enzyme	substrate	18548103
1-Beta-Ribofuranosyl-1,3-Diazepinone	--	--	target	--	--
1-Beta-Ribofuranosyl-1,3-Diazepinone	--	--	enzyme	--	--

10/17 Novoseek chemical compound relationships for CDA gene (see all 17) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	94.8	63	17194903 (2), 15492802 (2), 15713780 (2), 20010457 (2) (see all 53)
deoxycytidine	89.9	22	11705877 (3), 17296311 (2), 15492802 (2), 16585222 (1) (see all 15)
tetrahydrouridine	89.2	9	17296311 (1), 18562256 (1), 20043109 (1)
gemcitabine	80.4	53	19933910 (6), 17194903 (5), 12477049 (5), 20010457 (4) (see all 16)
cytarabine	68.4	12	15492802 (3), 14744791 (2), 11320667 (2), 19035178 (1) (see all 7)
ara-ctp	67.3	1	14744791 (1)
nucleoside	61.7	5	16585222 (1), 17296311 (1), 10499616 (1), 17094807 (1) (see all 5)
dctp	59.9	2	8494545 (1)
2-chlorodeoxyadenosine	45.5	4	10499616 (1), 11705877 (1)
pyrimidine	38.6	3	15147186 (1), 18058532 (1), 12406912 (1)

3 PharmGKB related drug/compound annotations for CDA gene

Drug/compound	PharmGKB Annotation
capecitabine	CA
cytarabine	CA
gemcitabine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about CDA / CDD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDA gene:

NM_001785.2

Unigene Cluster for CDA:

Cytidine deaminase

Hs.466910 [show with all ESTs]

Unigene Representative Sequence: BC048284

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375071(uc001bdk.3 uc001bdl.3 uc009vpv.3) ENST00000461985

miRNA Products:		OriGene 3'-UTR Clone: CDA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CDA:
		hsa-miR-1265 hsa-miR-374b hsa-miR-374a hsa-miR-3657
		SwitchGear 3'UTR luciferase reporter plasmid: CDA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDA (see all 7) OriGene shRNA RFP: CDA OriGene siRNA: CDA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDA (NM_001785)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDA

Additional cDNA sequence:

AJ000474.1 AY634312.2 BC048284.1 BC054036.1 L27943.1 S52873.1

6 DOTS entries:

DT.100754460 DT.409450 DT.95165565 DT.99985347 DT.91760241 DT.91793087

24/74 AceView cDNA sequences (see all 74):

AW950272 BF149259 CD675458 AV649418 AV647934 CB108404 BM557701 BM705637

BU734921 AJ705303 AJ000474 BM717211 BQ686897 AV660660 T28016 BM762918

BU595610 BQ447414 AV649252 BC054036 BM669253 CB109454 BM006349 CA415251

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDA (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d
SP1:																	-
SP2:																	-
SP3:													-				-
SP4:													-
SP5:													-				-		-

ECgene alternative splicing isoforms for CDA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGGTCCAGG

About this image

CDA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)

Cartilage

Cartilage-like cells (Differentiation of s...)

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDA

SOURCE GeneReport for Unigene cluster: Hs.466910

UniProtKB/Swiss-Prot: CDD_HUMAN, P32320

Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes,

monocytes, and T- as well as B-cell lines

SABiosciences Custom PCR Arrays for CDA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDA gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cda^{1 , 5}	cytidine deaminase^{1, 5}	83.79(n)¹ 81.51(a)¹		4 (70.17 cM)⁵ 72269¹ NM_028176.1¹ NP_082452.1¹ 138338424⁵
chicken (Gallus gallus)	Aves	CDA¹	cytidine deaminase	73.79(n) 74.05(a)		771849 NM_001146044.1 NP_001139516.1
lizard (Anolis carolinensis)	Reptilia	CDA⁶	--	63(a)	1 ↔ 1	AAWZ02039226(1244-1757)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.9365²	Transcribed sequence with weak similarity to protein more	77.57(n)		137696278
zebrafish (Danio rerio)	Actinopterygii	Dr.16208²	Transcribed sequence with weak similarity to protein more	76.85(n)		CD598599.1
fruit fly (Drosophila melanogaster)	Insecta	CG8360⁶ CG8353⁶ (see all 3)	--	39(a) 35(a) (see all 3)	many → 1 many → 1 (see all 3)	2L(8212959-8214135) 2L(8214045-8215239)
worm (Caenorhabditis elegans)	Secernentea	cdd-2⁶ cdd-1⁶	CytiDine Deaminase family member (cdd-1)	37(a) 36(a)	many → 1 many → 1	IV(7547107-7547882) X(8208700-8211098)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDD1(YLR245C)⁴ CDD1¹	Cytidine deaminase; catalyzes the modification of cytidine more⁴ Cdd1p¹	51.26(n)¹ 43.7(a)¹		12(626930-626502)⁴ 850946^{1, 4} NP_013346.1^{1, 4}

ENSEMBL Gene Tree for CDA (if available)
TreeFam Gene Tree for CDA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1253904^1,2	C,F,O,A,	--	20913519(-)	`CATACA/GTGAGG`	1	--	us2k¹		18		EA NA NS CSA	1243
rs187078918^1,2		--	20913529(+)	`GACCAA/CGTGCA`	1	--	us2k¹		0	--	--	--	--
rs191522439^1,2		--	20913530(+)	`ACCACA/GTGCAG`	1	--	us2k¹		0	--	--	--	--
rs12045976^1,2		--	20913609(+)	`TGGAGA/TCAAGG`	1	--	us2k¹		0	--	--	--	--
rs78133936^1,2		--	20913612(+)	`AGTCAA/GGGAGT`	1	--	us2k¹		0	--	--	--	--
rs201656353^1,2		--	20913614(+)	`CAAGG-/CAGTCC`	1	--	us2k¹		0	--	--	--	--
rs116320960^1,2		--	20913679(+)	`AGGGGA/GCAGGA`	1	--	us2k¹		1		WA	118
rs147220263^1,2		--	20913803(+)	`TTGAGC/TGGGCA`	1	--	us2k¹		0	--	--	--	--
rs183636573^1,2		--	20913891(+)	`AAAGTA/GCATGG`	1	--	us2k¹		0	--	--	--	--
rs114492748^1,2	C,F,	--	20913974(+)	`NNNNTC/TTGAAG`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for CDA (20915441 - 20945401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDA
1 CNV: 63233
Human Gene Mutation Database (HGMD): CDA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDA

DNA2.0 Custom Variant and Variant Library Synthesis for CDA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDA for disorders           About GeneDecksing

OMIM gene information: 123920    OMIM disorders: --

20/30 diseases for CDA (see all 30):    About MalaCards

childhood leukemia leukemia b-cell lymphomas hairy cell leukemia

lymphoblastic leukemia systemic lupus erythematosus lupus erythematosus hearing loss

acute lymphoblastic leukemia acute myeloid leukemia myeloid leukemia acute leukemia

leukopenia t-cell leukemia rheumatoid arthritis down syndrome

arthritis ovarian cancer gastric cancer pancreatic cancer

1 disease from the University of Copenhagen DISEASES database for CDA:

Chronic lymphocytic leukemia

10 Novoseek disease relationships for CDA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acute leukemia	44.1	3	19035178 (1), 18067088 (1), 16446974 (1)
leukemia	36	9	11320667 (3), 19099730 (2), 15492802 (1), 11705877 (1) (see all 5)
solid tumor	34.9	2	11320667 (1)
hematologic malignancies	31.4	1	19099730 (1)
lymphoblastic leukemia acute	26.7	1	10499616 (1)
cancer	15.6	7	15814642 (2), 17194903 (1), 17885621 (1), 8494545 (1) (see all 6)
nsclc	6.6	1	20211060 (2), 18347182 (2), 19500405 (1), 20213492 (1)
carcinoma	0.3	5	15492802 (4), 15867251 (1)
cancer lung	0	1	20213492 (1)
tumors	0	4	16585222 (2), 12477049 (1)

Human Genome Epidemiology (HuGE) Navigator: CDA (28 documents)

Export disorders for CDA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDA gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with CDA)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of the gene coding for human cytidine deaminase. (PubMed id 9878810)^{1, 2, 3} Demontis S....Garattini E. (1998)
Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. (PubMed id 8422236)^{1, 2, 3} Kuhn K.... Emmrich F. (1993)
Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. (PubMed id 18600531)^{1, 7, 9} Giovannetti E....Peters G.J. (2008)
Structure of human cytidine deaminase bound to a potent inhibitor. (PubMed id 15689149)^{1, 2, 9} Chung S.J.... Verdine G.L. (2005)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Growth inhibition of granulocyte-macrophage colony forming cells by human cytidine deaminase requires the catalytic function of the protein. (PubMed id 9596658)^{1, 2} Gran C.... Seeberg E.C. (1998)
Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. (PubMed id 7923172)^{1, 2} Laliberte J. and Momparler R.L. (1994)
Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue. (PubMed id 16303324)^{1, 9} Costanzi S....Vita A. (2006)
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. (PubMed id 17194903)^{1, 9} Sugiyama E....Saijo N. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 978	HGNC: 1712	AceView: CDA	Ensembl:ENSG00000158825	euGenes: HUgn978
ECgene: CDA	Kegg: 978	H-InvDB: CDA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDA gene:
Search GeneIP for patents involving CDA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CDA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDA
	OriGene Protein Over-expression Lysate for CDA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CDA		OriGene 3'-UTR Clone for CDA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CDA		OriGene Custom Protein Services for CDA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDA

	GenScript Custom Purified and Recombinant Proteins Services for CDA		GenScript cDNA clones with any tag delivered in your preferred vector for CDA
	GenScript Custom Assay Services for CDA		GenScript Custom Superior Antibodies Services for CDA
	GenScript Custom overexpressing Cell Line Services for CDA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CDA promoter
	Search Chromatin IP Primers for CDA
	RT² qPCR Primer Assay in human, mouse, rat CDA
	GNC Network for CDA
	SABiosciences Custom PCR Arrays for CDA

Search Tocris compounds for CDA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CDA antibodies
	CDA proteins
	CDA lysates

	Antibodies for CDA
	See all of Abcam's Antibodies, Kits and Proteins for CDA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CDA

CDA Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CDA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDA

	SwitchGear 3'UTR luciferase reporter plasmids for CDA
	SwitchGear Promoter luciferase reporter plasmids for CDA

ThermoFisher Antibodies for CDA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDA gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CDA Gene

cytidine deaminase

Aliases
for CDA gene

Summaries
for CDA gene

Genomic Views
for CDA gene

Proteins
for CDA gene

Protein Domains /
Families
for CDA gene

Function
for CDA gene

Pathways & Interactions
for CDA gene

Drugs & Compounds
for CDA gene

Transcripts
for CDA gene

Expression
for CDA gene

Orthologs
for CDA gene

Paralogs
for CDA gene

Genomic Variants
for CDA gene

Disorders / Diseases
for CDA gene

Publications
for CDA gene

External Searches for CDA gene

Genome Databases showing CDA gene

Other Databases showing CDA gene

Specialized Databases showing CDA gene

Intellectual Property
for CDA gene

Products
for CDA gene

View Random Gene

Advanced Search

Export list of displayed genes

CDA Gene

cytidine deaminase

Aliasesfor CDA gene

Summariesfor CDA gene

Genomic Viewsfor CDA gene

Proteinsfor CDA gene

Protein Domains /Familiesfor CDA gene

Functionfor CDA gene

Pathways & Interactionsfor CDA gene

Drugs & Compoundsfor CDA gene

Transcriptsfor CDA gene

Expression for CDA gene

Orthologsfor CDA gene

Paralogsfor CDA gene

Genomic Variantsfor CDA gene

Disorders / Diseasesfor CDA gene

Publicationsfor CDA gene

External Searches for CDA gene

Genome Databases showing CDA gene

Other Databases showing CDA gene

Specialized Databases showing CDA gene

Intellectual Propertyfor CDA gene

Productsfor CDA gene

View Random Gene

Aliases
for CDA gene

Summaries
for CDA gene

Genomic Views
for CDA gene

Proteins
for CDA gene

Protein Domains /
Families
for CDA gene

Function
for CDA gene

Pathways & Interactions
for CDA gene

Drugs & Compounds
for CDA gene

Transcripts
for CDA gene

Expression
for CDA gene

Orthologs
for CDA gene

Paralogs
for CDA gene

Genomic Variants
for CDA gene

Disorders / Diseases
for CDA gene

Publications
for CDA gene

Intellectual Property
for CDA gene

Products
for CDA gene