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Aliases for CD99L2 Gene

Aliases for CD99L2 Gene

  • CD99 Molecule Like 2 2 3 5
  • MIC2-Like Protein 1 3 4
  • MIC2 Like 1 2 3
  • MIC2L1 3 4
  • CD99 Antigen-Like Protein 2 3
  • CD99 Molecule-Like 2 2
  • CD99 Antigen-Like 2 2
  • CD99 Antigen 4
  • CD99B 3

External Ids for CD99L2 Gene

Previous HGNC Symbols for CD99L2 Gene

  • MIC2L1

Previous GeneCards Identifiers for CD99L2 Gene

  • GC0XM146617
  • GC0XM147705
  • GC0XM148576
  • GC0XM148577
  • GC0XM149605
  • GC0XM149934
  • GC0XM138794

Summaries for CD99L2 Gene

Entrez Gene Summary for CD99L2 Gene

  • This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for CD99L2 Gene

CD99L2 (CD99 Molecule Like 2) is a Protein Coding gene. Diseases associated with CD99L2 include Cerebral Palsy. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.

UniProtKB/Swiss-Prot for CD99L2 Gene

  • Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Wiki entry for CD99L2 Gene

Additional gene information for CD99L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD99L2 Gene

Genomics for CD99L2 Gene

Regulatory Elements for CD99L2 Gene

Enhancers for CD99L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH150846 1.5 FANTOM5 Ensembl ENCODE 25.1 +49.0 48987 5 FOXA2 ARID4B SIN3A YY1 TCF12 FOS REST ZNF592 SREBF1 MIER3 CD99L2 MTMR1 HMGB3 PPIAP91
GH0XH150841 0.9 Ensembl ENCODE 23.4 +55.0 55018 5 CEBPB MAFG MAX CEBPG NR3C1 NR2F2 YY1 SREBF1 ZNF316 NFE2 CD99L2 PPIAP91
GH0XH150871 0.5 ENCODE 29.4 +25.7 25701 2 FOS DPF2 EMSY CD99L2 HMGB3 PPIAP91
GH0XH150772 1 Ensembl ENCODE 12.2 +126.4 126416 0 CTCF RB1 ZNF2 RAD21 CC2D1A PATZ1 SMC3 CREM ZNF654 MAZ CD99L2 PIR43679 PPIAP91
GH0XH150897 0.9 ENCODE 8.8 +0.1 94 2 TBP ATF1 RB1 ZSCAN4 ZNF76 NFXL1 BRCA1 YY1 GLIS2 GATA2 CD99L2 PPIAP91
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD99L2 on UCSC Golden Path with GeneCards custom track

Promoters for CD99L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249438 116 2201 TBP RB1 ZSCAN4 ZNF76 NFXL1 BRCA1 YY1 GLIS2 GATA2 ATF7

Genomic Location for CD99L2 Gene

Chromosome:
X
Start:
150,766,336 bp from pter
End:
150,898,816 bp from pter
Size:
132,481 bases
Orientation:
Minus strand

Genomic View for CD99L2 Gene

Genes around CD99L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD99L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD99L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99L2 Gene

Proteins for CD99L2 Gene

  • Protein details for CD99L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCZ2-C99L2_HUMAN
    Recommended name:
    CD99 antigen-like protein 2
    Protein Accession:
    Q8TCZ2
    Secondary Accessions:
    • A8K2D5
    • A8K5R0
    • B3KWG2
    • B4DDL7
    • E7EMK5
    • E9PD27
    • Q8TAW2
    • Q8TCZ0
    • Q8TCZ1
    • Q9BQG9

    Protein attributes for CD99L2 Gene

    Size:
    262 amino acids
    Molecular mass:
    27986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66515.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Alternative splice isoforms for CD99L2 Gene

neXtProt entry for CD99L2 Gene

Post-translational modifications for CD99L2 Gene

Antibody Products

No data available for DME Specific Peptides for CD99L2 Gene

Domains & Families for CD99L2 Gene

Gene Families for CD99L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD99L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCZ2

UniProtKB/Swiss-Prot:

C99L2_HUMAN :
  • Belongs to the CD99 family.
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99L2: view

Function for CD99L2 Gene

Molecular function for CD99L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Phenotypes From GWAS Catalog for CD99L2 Gene

Gene Ontology (GO) - Molecular Function for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD99L2: view
genes like me logo Genes that share phenotypes with CD99L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD99L2

CRISPR Products

miRNA for CD99L2 Gene

miRTarBase miRNAs that target CD99L2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD99L2 Gene

Localization for CD99L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99L2 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD99L2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Intermediate filaments (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CD99L2: view

Pathways & Interactions for CD99L2 Gene

genes like me logo Genes that share pathways with CD99L2: view

Pathways by source for CD99L2 Gene

2 Reactome pathways for CD99L2 Gene

Interacting Proteins for CD99L2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359403%0d%0a9606.ENSP00000347836%0d%0a9606.ENSP00000349929%0d%0a9606.ENSP00000392257%0d%0a9606.ENSP00000290158%0d%0a9606.ENSP00000357943%0d%0a
Selected Interacting proteins: Q8TCZ2-C99L2_HUMAN ENSP00000359403 for CD99L2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD99L2: view

No data available for SIGNOR curated interactions for CD99L2 Gene

Drugs & Compounds for CD99L2 Gene

No Compound Related Data Available

Transcripts for CD99L2 Gene

Unigene Clusters for CD99L2 Gene

CD99 molecule-like 2:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CD99L2 Gene

GeneLoc Exon Structure for
CD99L2
ECgene alternative splicing isoforms for
CD99L2

Expression for CD99L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD99L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD99L2 Gene

This gene is overexpressed in Fetal Brain (18.4), Urine (18.2), and Cerebrospinal fluid (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD99L2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD99L2 Gene:

CD99L2

SOURCE GeneReport for Unigene cluster for CD99L2 Gene:

Hs.522805

mRNA Expression by UniProt/SwissProt for CD99L2 Gene:

Q8TCZ2-C99L2_HUMAN
Tissue specificity: Expressed in many tissues, with low expression in thymus.

Evidence on tissue expression from TISSUES for CD99L2 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Muscle(4.4)
  • Blood(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CD99L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD99L2 Gene

Orthologs for CD99L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD99L2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD99L2 33 34
  • 85.41 (n)
dog
(Canis familiaris)
Mammalia CD99L2 33 34
  • 84.83 (n)
mouse
(Mus musculus)
Mammalia Cd99l2 33 16 34
  • 76.44 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559441 33
  • 73.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD99L2 34
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD99L2 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD99L2 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD99L2 34
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd99l2 33 34
  • 36 (a)
Species where no ortholog for CD99L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD99L2 Gene

ENSEMBL:
Gene Tree for CD99L2 (if available)
TreeFam:
Gene Tree for CD99L2 (if available)

Paralogs for CD99L2 Gene

(1) SIMAP similar genes for CD99L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD99L2: view

No data available for Paralogs for CD99L2 Gene

Variants for CD99L2 Gene

Sequence variations from dbSNP and Humsavar for CD99L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000004106 -- 150,878,712(+) AGTAA(C/T)TTTTT intron-variant
rs1000022512 -- 150,781,463(+) CTGGA(A/G)AGAGA intron-variant
rs1000182860 -- 150,832,459(+) TCTCT(A/G)TCAAA intron-variant
rs1000296065 -- 150,845,741(+) CTCCC(A/C)TGGTA intron-variant
rs1000300751 -- 150,770,767(+) AGTGA(C/T)TGATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD99L2 Gene

Variant ID Type Subtype PubMed ID
dgv1405e199 CNV deletion 23128226
dgv2528e212 CNV loss 25503493
esv1216901 CNV deletion 17803354
esv1531534 CNV deletion 17803354
esv2740598 CNV deletion 23290073
esv2740599 CNV deletion 23290073
esv3559461 CNV deletion 23714750
esv3574980 CNV loss 25503493
esv3574981 CNV loss 25503493
esv3577530 CNV gain 25503493
nsv1124525 CNV deletion 24896259
nsv508813 CNV insertion 20534489
nsv510567 OTHER sequence alteration 20534489
nsv525661 CNV gain 19592680
nsv7150 CNV insertion 18451855
nsv7151 CNV deletion 18451855

Variation tolerance for CD99L2 Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD99L2 Gene

Human Gene Mutation Database (HGMD)
CD99L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD99L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99L2 Gene

Disorders for CD99L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD99L2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cerebral palsy
  • infantile cerebral palsy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CD99L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD99L2
genes like me logo Genes that share disorders with CD99L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD99L2 Gene

Publications for CD99L2 Gene

  1. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PMID: 12706889) Suh YH … Park SH (Gene 2003) 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CD99L2 Gene

Sources for CD99L2 Gene

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