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Aliases for CD99L2 Gene

Aliases for CD99L2 Gene

  • CD99 Molecule Like 2 2 3 5
  • CD99 Molecule-Like 2 2 3
  • MIC2-Like Protein 1 3 4
  • MIC2 Like 1 2 3
  • MIC2L1 3 4
  • CD99 Antigen-Like 2 2
  • CD99 Antigen 4
  • CD99B 3

External Ids for CD99L2 Gene

Previous HGNC Symbols for CD99L2 Gene

  • MIC2L1

Previous GeneCards Identifiers for CD99L2 Gene

  • GC0XM146617
  • GC0XM147705
  • GC0XM148576
  • GC0XM148577
  • GC0XM149605
  • GC0XM149934
  • GC0XM138794

Summaries for CD99L2 Gene

Entrez Gene Summary for CD99L2 Gene

  • This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for CD99L2 Gene

CD99L2 (CD99 Molecule Like 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CD99L2 Gene

  • Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Wiki entry for CD99L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD99L2 Gene

Genomics for CD99L2 Gene

Regulatory Elements for CD99L2 Gene

Promoters for CD99L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD99L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD99L2 Gene

Chromosome:
X
Start:
150,766,336 bp from pter
End:
150,898,816 bp from pter
Size:
132,481 bases
Orientation:
Minus strand

Genomic View for CD99L2 Gene

Genes around CD99L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD99L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD99L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99L2 Gene

Proteins for CD99L2 Gene

  • Protein details for CD99L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCZ2-C99L2_HUMAN
    Recommended name:
    CD99 antigen-like protein 2
    Protein Accession:
    Q8TCZ2
    Secondary Accessions:
    • A8K2D5
    • A8K5R0
    • B3KWG2
    • B4DDL7
    • E7EMK5
    • E9PD27
    • Q8TAW2
    • Q8TCZ0
    • Q8TCZ1
    • Q9BQG9

    Protein attributes for CD99L2 Gene

    Size:
    262 amino acids
    Molecular mass:
    27986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66515.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Alternative splice isoforms for CD99L2 Gene

neXtProt entry for CD99L2 Gene

Proteomics data for CD99L2 Gene at MOPED

Post-translational modifications for CD99L2 Gene

Antibody Products

No data available for DME Specific Peptides for CD99L2 Gene

Domains & Families for CD99L2 Gene

Protein Domains for CD99L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCZ2

UniProtKB/Swiss-Prot:

C99L2_HUMAN :
  • Belongs to the CD99 family.
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99L2: view

No data available for Gene Families for CD99L2 Gene

Function for CD99L2 Gene

Molecular function for CD99L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Phenotypes for CD99L2 Gene

genes like me logo Genes that share phenotypes with CD99L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD99L2

miRNA for CD99L2 Gene

miRTarBase miRNAs that target CD99L2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD99L2 Gene

Localization for CD99L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99L2 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD99L2 Gene COMPARTMENTS Subcellular localization image for CD99L2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD99L2: view

Pathways & Interactions for CD99L2 Gene

SuperPathways for CD99L2 Gene

No Data Available

Interacting Proteins for CD99L2 Gene

Selected Interacting proteins: Q8TCZ2-C99L2_HUMAN for CD99L2 Gene via UniProtKB

Symbol External ID(s) Details
UBQLN1

Gene Ontology (GO) - Biological Process for CD99L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CD99L2 Gene

Drugs & Compounds for CD99L2 Gene

No Compound Related Data Available

Transcripts for CD99L2 Gene

Unigene Clusters for CD99L2 Gene

CD99 molecule-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CD99L2 Gene

GeneLoc Exon Structure for
CD99L2
ECgene alternative splicing isoforms for
CD99L2

Expression for CD99L2 Gene

mRNA expression in normal human tissues for CD99L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD99L2 Gene

This gene is overexpressed in Fetal Brain (18.4), Urine (18.2), and Cerebrospinal fluid (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CD99L2 Gene



SOURCE GeneReport for Unigene cluster for CD99L2 Gene Hs.522805

mRNA Expression by UniProt/SwissProt for CD99L2 Gene

Q8TCZ2-C99L2_HUMAN
Tissue specificity: Expressed in many tissues, with low expression in thymus.
genes like me logo Genes that share expression patterns with CD99L2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CD99L2 Gene

Orthologs for CD99L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD99L2 35
  • 85.41 (n)
  • 81.59 (a)
CD99L2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD99L2 35
  • 84.83 (n)
  • 85.39 (a)
CD99L2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd99l2 35
  • 76.44 (n)
  • 73.78 (a)
Cd99l2 16
Cd99l2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1559441 35
  • 73.42 (n)
  • 66.22 (a)
oppossum
(Monodelphis domestica)
Mammalia CD99L2 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD99L2 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD99L2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD99L2 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD99L2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd99l2 35
cd99l2 36
  • 36 (a)
OneToOne
Species with no ortholog for CD99L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD99L2 Gene

ENSEMBL:
Gene Tree for CD99L2 (if available)
TreeFam:
Gene Tree for CD99L2 (if available)

Paralogs for CD99L2 Gene

(1) SIMAP similar genes for CD99L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD99L2: view

No data available for Paralogs for CD99L2 Gene

Variants for CD99L2 Gene

Sequence variations from dbSNP and Humsavar for CD99L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6877 -- 150,766,627(-) TCTCT(A/G)TCAGC utr-variant-3-prime
rs7987 -- 150,767,050(-) CCTGT(C/T)GGATG utr-variant-3-prime
rs9866 -- 150,767,630(-) GGGAT(G/T)AGCCA utr-variant-3-prime
rs596789 -- 150,897,813(+) atgca(C/G)aatca intron-variant
rs605206 -- 150,899,736(-) TGGTA(C/G)TAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD99L2 Gene

Variant ID Type Subtype PubMed ID
nsv525661 CNV Gain 19592680
nsv508813 CNV Insertion 20534489
esv2740598 CNV Deletion 23290073
esv2740599 CNV Deletion 23290073
dgv1405e199 CNV Deletion 23128226
nsv7150 CNV Insertion 18451855
nsv510567 CNV Loss 20534489
nsv7151 CNV Loss 18451855
esv1531534 CNV Deletion 17803354
esv1216901 CNV Deletion 17803354

Variation tolerance for CD99L2 Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD99L2 Gene

HapMap Linkage Disequilibrium report
CD99L2
Human Gene Mutation Database (HGMD)
CD99L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99L2 Gene

Disorders for CD99L2 Gene

Relevant External Links for CD99L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD99L2

No disorders were found for CD99L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD99L2 Gene

Publications for CD99L2 Gene

  1. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PMID: 12706889) Suh Y.H. … Park S.H. (Gene 2003) 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for I^-Pix in negative regulation of focal adhesion maturation. (PMID: 21423176) Kuo J.C. … Waterman C.M. (Nat. Cell Biol. 2011) 3
  4. The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. (PMID: 18163232) Schenkel A.R. … Muller W.A. (Cell Commun. Adhes. 2007) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for CD99L2 Gene

Sources for CD99L2 Gene

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