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Aliases for CD99L2 Gene

Aliases for CD99L2 Gene

  • CD99 Molecule-Like 2 2 3
  • MIC2-Like Protein 1 3 4
  • MIC2 Like 1 2 3
  • MIC2L1 3 4
  • CD99B 3 6
  • CD99 Antigen-Like Protein 2 3
  • CD99 Antigen-Like 2 2
  • CD99 Antigen 4

External Ids for CD99L2 Gene

Previous HGNC Symbols for CD99L2 Gene

  • MIC2L1

Previous GeneCards Identifiers for CD99L2 Gene

  • GC0XM146617
  • GC0XM147705
  • GC0XM148576
  • GC0XM148577
  • GC0XM149605
  • GC0XM149934
  • GC0XM138794

Summaries for CD99L2 Gene

Entrez Gene Summary for CD99L2 Gene

  • This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for CD99L2 Gene

CD99L2 (CD99 Molecule-Like 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CD99L2 Gene

  • Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Wiki entry for CD99L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD99L2 Gene

Genomics for CD99L2 Gene

Regulatory Elements for CD99L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD99L2 Gene

Start:
150,766,336 bp from pter
End:
150,898,816 bp from pter
Size:
132,481 bases
Orientation:
Minus strand

Genomic View for CD99L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD99L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99L2 Gene

Proteins for CD99L2 Gene

  • Protein details for CD99L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCZ2-C99L2_HUMAN
    Recommended name:
    CD99 antigen-like protein 2
    Protein Accession:
    Q8TCZ2
    Secondary Accessions:
    • A8K2D5
    • A8K5R0
    • B3KWG2
    • B4DDL7
    • E7EMK5
    • E9PD27
    • Q8TAW2
    • Q8TCZ0
    • Q8TCZ1
    • Q9BQG9

    Protein attributes for CD99L2 Gene

    Size:
    262 amino acids
    Molecular mass:
    27986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66515.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Alternative splice isoforms for CD99L2 Gene

neXtProt entry for CD99L2 Gene

Proteomics data for CD99L2 Gene at MOPED

Post-translational modifications for CD99L2 Gene

Antibody Products

No data available for DME Specific Peptides for CD99L2 Gene

Domains for CD99L2 Gene

Protein Domains for CD99L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCZ2

UniProtKB/Swiss-Prot:

C99L2_HUMAN :
  • Q8TCZ2
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99L2: view

No data available for Gene Families for CD99L2 Gene

Function for CD99L2 Gene

Molecular function for CD99L2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Ontology (GO) - Molecular Function for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD99L2: view

Animal Model Products

CRISPR Products

miRNA for CD99L2 Gene

miRTarBase miRNAs that target CD99L2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD99L2 Gene

Localization for CD99L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99L2 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD99L2 Gene COMPARTMENTS Subcellular localization image for CD99L2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD99L2: view

Pathways for CD99L2 Gene

SuperPathways for CD99L2 Gene

No Data Available

Interacting Proteins for CD99L2 Gene

Selected Interacting proteins: Q8TCZ2-C99L2_HUMAN for CD99L2 Gene via UniProtKB

Symbol External ID(s) Details
UBQLN1

Gene Ontology (GO) - Biological Process for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD99L2: view

No data available for Pathways by source for CD99L2 Gene

Transcripts for CD99L2 Gene

Unigene Clusters for CD99L2 Gene

CD99 molecule-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD99L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CD99L2 Gene

GeneLoc Exon Structure for
CD99L2
ECgene alternative splicing isoforms for
CD99L2

Expression for CD99L2 Gene

mRNA expression in normal human tissues for CD99L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD99L2 Gene

SOURCE GeneReport for Unigene cluster for CD99L2 Gene Hs.522805

mRNA Expression by UniProt/SwissProt for CD99L2 Gene

Q8TCZ2-C99L2_HUMAN
Tissue specificity: Expressed in many tissues, with low expression in thymus.
genes like me logo Genes that share expressions with CD99L2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD99L2 Gene

Orthologs for CD99L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD99L2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD99L2 35
  • 85.41 (n)
  • 81.59 (a)
CD99L2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD99L2 35
  • 84.83 (n)
  • 85.39 (a)
CD99L2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd99l2 35
  • 76.44 (n)
  • 73.78 (a)
Cd99l2 16
Cd99l2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD99L2 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD99L2 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1559441 35
  • 73.42 (n)
  • 66.22 (a)
chicken
(Gallus gallus)
Aves CD99L2 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD99L2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd99l2 35
cd99l2 36
  • 36 (a)
OneToOne
Species with no ortholog for CD99L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD99L2 Gene

ENSEMBL:
Gene Tree for CD99L2 (if available)
TreeFam:
Gene Tree for CD99L2 (if available)

Paralogs for CD99L2 Gene

Selected SIMAP similar genes for CD99L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD99L2: view

No data available for Paralogs for CD99L2 Gene

Variants for CD99L2 Gene

Sequence variations from dbSNP and Humsavar for CD99L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6877 -- 150,766,627(-) TCTCT(A/G)TCAGC utr-variant-3-prime
rs7987 -- 150,767,050(-) CCTGT(C/T)GGATG utr-variant-3-prime
rs9866 -- 150,767,630(-) GGGAT(G/T)AGCCA utr-variant-3-prime
rs596789 -- 150,897,813(+) atgca(C/G)aatca intron-variant
rs605206 -- 150,899,736(-) TGGTA(C/G)TAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD99L2 Gene

Variant ID Type Subtype PubMed ID
nsv525661 CNV Gain 19592680
nsv508813 CNV Insertion 20534489
esv2740598 CNV Deletion 23290073
esv2740599 CNV Deletion 23290073
dgv1405e199 CNV Deletion 23128226
nsv7150 CNV Insertion 18451855
nsv510567 CNV Loss 20534489
nsv7151 CNV Loss 18451855
esv1531534 CNV Deletion 17803354
esv1216901 CNV Deletion 17803354

Relevant External Links for CD99L2 Gene

HapMap Linkage Disequilibrium report
CD99L2
Locus Specific Mutation Databases (LSDB)
CD99L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99L2 Gene

Disorders for CD99L2 Gene

No disorders were found for CD99L2 Gene.

No data available for UniProtKB/Swiss-Prot for CD99L2 Gene

Publications for CD99L2 Gene

  1. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PMID: 12706889) Suh Y.H. … Park S.H. (Gene 2003) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for CD99L2 Gene

Sources for CD99L2 Gene

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