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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD99L2 Gene

protein-coding   GIFtS: 49
GCID: GC0XM149934

CD99 molecule-like 2

(Previous names: MIC2 like 1, CD99 antigen-like 2 )
(Previous symbol: MIC2L1)
  Search for CD99L2
in our new
 Human Malady Compendium 
Biological research products
for CD99L2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CD99 Molecule-Like 21 2     MIC2-Like Protein 12 3
MIC2L11 2 3     CD99 Antigen-Like 21
CD99B1 2     CD99 Antigen-Like Protein 22
MIC2 Like 11 2     CD99 Antigen3

External Ids:    HGNC: 182371   Entrez Gene: 836922   Ensembl: ENSG000001021817   OMIM: 3008465   UniProtKB: Q8TCZ23   

Export aliases for CD99L2 gene to outside databases

Previous GC identifers: GC0XM146617 GC0XM147705 GC0XM148576 GC0XM148577 GC0XM149605 GC0XM138794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD99L2:
This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion
molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, May 2010)

UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2
Function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement
membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but
these interactions may not be required for cell aggregation (By similarity)

Gene Wiki entry for CD99L2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD99L2 gene promoter:
         PPAR-gamma1   AML1a   Pax-6   FOXO3a   FOXO3   PPAR-gamma2   ITF-2   Tal-1beta   FOXO3b   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD99L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD99L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD99L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

CD99L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD99L2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM149934:  view genomic region     (about GC identifiers)

Start:
149,934,809 bp from pter      End:
150,067,289 bp from pter
Size:
132,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2 (See protein sequence)
Recommended Name: CD99 antigen-like protein 2 precursor  
Size: 262 amino acids; 27986 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Cell
junction (By similarity)
Sequence caution: Sequence=CAB66515.1; Type=Frameshift; Positions=156;
Secondary accessions: A8K2D5 A8K5R0 B3KWG2 B4DDL7 E7EMK5 E9PD27 Q8TAW2 Q8TCZ0 Q8TCZ1 Q9BQG9
Alternative splicing: 6 isoforms:  Q8TCZ2-1   Q8TCZ2-2   Q8TCZ2-3   Q8TCZ2-4   Q8TCZ2-5   Q8TCZ2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD99L2: NX_Q8TCZ2

Post-translational modifications:

  • O-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCZ2

  • CD99L2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171737.1  NP_001229543.1  NP_113650.2  NP_604394.1  NP_604395.1  

    ENSEMBL proteins: 
     ENSP00000359403   ENSP00000417697   ENSP00000391821   ENSP00000347275   ENSP00000394858  
     ENSP00000325449  

    Human Recombinant Protein Products: 
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    Uscn Proteins for CD99L2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--


    CD99L2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CD99L2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR022078 CD99L2

    Graphical View of Domain Structure for InterPro Entry Q8TCZ2

    ProtoNet protein and cluster: Q8TCZ2

    UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2
    Similarity: Belongs to the CD99 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2
    Function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement
    membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but
    these interactions may not be required for cell aggregation (By similarity)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD99L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD99L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for CD99L2 (ENSP000003594034) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA2ENSP000003460324STRING: ENSP00000346032
    KPNB1ENSP000002901584STRING: ENSP00000290158
    PPIDENSP000003037544STRING: ENSP00000303754
    SDCCAG3ENSP000003499294STRING: ENSP00000349929
    TRIP13ENSP000001663454STRING: ENSP00000166345
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    CD99L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD99L2
    Search CenterWatch for drugs/clinical trials and news about CD99L2 / C99L2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD99L2 gene (5 alternative transcripts): 
    NM_001184808.1  NM_001242614.1  NM_031462.3  NM_134445.3  NM_134446.3  

    Unigene Cluster for CD99L2:

    CD99 molecule-like 2
    Hs.522805  [show with all ESTs]
    Unigene Representative Sequence: BC025729
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370377(uc004fek.3 uc004fel.3) ENST00000346693(uc004feo.3)
    ENST00000466436 ENST00000418547 ENST00000491877 ENST00000355149(uc004fem.3 uc004fen.3)
    ENST00000437787(uc011myb.2) ENST00000320893

    miRNA
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    hsa-miR-155 hsa-miR-138 hsa-miR-1205 hsa-miR-628-5p hsa-miR-548q
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK023776.1 AK024278.1 AK098810.1 AK125020.1 AK290200.1 AK291375.1 AK293244.1 AK295217.1 
    AL136580.1 AY078165.1 AY078166.1 AY078167.1 AY358837.1 BC007569.1 BC013029.2 BC019857.1 
    BC025729.1 BC030536.1 

    23 DOTS entries:

    DT.100660224  DT.75156472  DT.95342521  DT.95181825  DT.100809899  DT.100809907  DT.95088176  DT.95202844 
    DT.100809910  DT.95202833  DT.97815480  DT.92460392  DT.121317136  DT.121317137  DT.121317146  DT.121317160 
    DT.121317163  DT.121317169  DT.121317234  DT.121317238  DT.121317244  DT.40122837  DT.95242155 

    24/305 AceView cDNA sequences (see all 305):

    BE907131 BU153008 CB156449 BQ933632 AA426346 CF242888 AW074581 F35778 
    CB215999 AI090664 AY358837 AA323297 AL569981 BQ879176 BP373611 BC019857 
    AK098810 AY078166 AA775884 AA778021 CO247545 AU279604 BQ889880 CR610005 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                          -     -                                         -           -     -                                 
    SP2:                          -                                                                                                   
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CD99L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD99L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGGTGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CD99L2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CD99L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD99L2

    SOURCE GeneReport for Unigene cluster: Hs.522805

    UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2
    Tissue specificity: Expressed in many tissues, with low expression in thymus

        SABiosciences Custom PCR Arrays for CD99L2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD99L2 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd99l21 , 5 CD99 antigen-like 21, 5 82.19(n)1
    80.77(a)1
      X (36.82 cM)5
    1714861  NM_001199349.11  NP_001186278.11 
     714200605 
    chicken
    (Gallus gallus)
    Aves CD99L21 CD99 molecule-like 2 63.27(n)
    60.68(a)
      422386  XM_420355.3  XP_420355.3 
    lizard
    (Anolis carolinensis)
    Reptilia CD99L26
    --
    66(a)
    1 ↔ 1
    GL343310.1(729640-741822)
    zebrafish
    (Danio rerio)
    Actinopterygii cd99l22 CD99 antigen-like 2 77.4(n)   323266  AY078168.1 


    ENSEMBL Gene Tree for CD99L2 (if available)
    TreeFam Gene Tree for CD99L2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD99L2 gene
    CD992  
    1 SIMAP similar gene for CD99L2 using alignment to 3 protein entries:     C99L2_HUMAN (see all proteins):
    CD99

    CD99L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1686 NCBI SNPs in CD99L2 are shown (see all 1686    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909564541,2
    --149934368(+) TCTGGC/TTGAAA 5 -- ds50010--------
    rs1831824611,2
    --149934519(+) GGCCCC/TGCAGC 5 -- ds50010--------
    rs1859734991,2
    --149934801(+) CAGAAA/GACAAG 5 -- ds50010--------
    rs1918221071,2
    --149934950(+) CTGAAC/GCCCAG 5 -- ut310--------
    rs2021695871,2
    --149935065(+) TCAGA-/GTTGTTGT 5 -- ut310--------
    rs68771,2
    C,F,A,H,--149935100(-) TCTCTA/GTCAGC 5 -- ut31 ese332Minor allele frequency- N:0.00MN NS EA NA WA CSA 3071
    rs413134121,2
    --149935398(+) CGGGGC/TGGGGG 5 -- ut310--------
    rs79871,2
    C,--149935523(-) CCTGTC/TGGATG 5 -- ut31 ese32Minor allele frequency- T:0.00MN NA 186
    rs1882931611,2
    --149935535(+) CTCACA/CATAAA 5 -- ut310--------
    rs1925267971,2
    --149935582(+) GTGGCA/GACAGG 5 -- ut310--------

    HapMap Linkage Disequilibrium report for CD99L2 (149934809 - 150067289 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CD99L2
         2 CNVs: 97078 83839
         1 Indel: 29287
    Locus Specific Mutation Databases (LSDB): CD99L2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD99L2
    DNA2.0 Custom Variant and Variant Library Synthesis for CD99L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CD99L2 for disorders           About MalaCards

    CD99L2 for disorders           About GeneDecksing

    OMIM gene information: 300846    OMIM disorders: --


    Export disorders for CD99L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD99L2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CD99L2)
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    world of online information

    1. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PubMed id 12706889)1, 2, 9 Suh Y.H.... Park S.H. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. (PubMed id 18163232)1 Schenkel A.R....Muller W.A. (2007)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83692 HGNC: 18237 AceView: CD99L2 Ensembl:ENSG00000102181 euGenes: HUgn83692
    ECgene: CD99L2 H-InvDB: CD99L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD99L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD99L2 gene:
    Search GeneIP for patents involving CD99L2

    GeneCards and IP:
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