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Aliases for CD99 Gene

Aliases for CD99 Gene

  • CD99 Molecule (Xg Blood Group) 2 3 5
  • CD99 Antigen 2 3 4
  • Antigen Identified By Monoclonal Antibodies 12E7, F21 And O13 2 3
  • T-Cell Surface Glycoprotein E2 3 4
  • E2 Antigen 3 4
  • MIC2X 3 4
  • MIC2Y 3 4
  • MIC2 3 4
  • Antigen Identified By Monoclonal 12E7, Y Homolog 3
  • MIC2 (Monoclonal Antibody 12E7) 3
  • Cell Surface Antigen HBA-71 3
  • Cell Surface Antigen 12E7 3
  • Cell Surface Antigen O13 3
  • Surface Antigen MIC2 3
  • CD99 Molecule 2
  • Protein MIC2 4
  • HBA71 3
  • MSK5X 3
  • 12E7 4

External Ids for CD99 Gene

Previous HGNC Symbols for CD99 Gene

  • MIC2

Previous GeneCards Identifiers for CD99 Gene

  • GC0XP001778
  • GC0XP002139
  • GC0XP002204
  • GC0YP002602
  • GC0XP002602
  • GC0XP000550

Summaries for CD99 Gene

Entrez Gene Summary for CD99 Gene

  • The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]

GeneCards Summary for CD99 Gene

CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing's Sarcoma and Ewing Sarcoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall.

UniProtKB/Swiss-Prot for CD99 Gene

  • Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

Gene Wiki entry for CD99 Gene

Additional gene information for CD99 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD99 Gene

Genomics for CD99 Gene

GeneHancer (GH) Regulatory Elements for CD99 Gene

Promoters and enhancers for CD99 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI002690 Promoter/Enhancer 1.4 Ensembl dbSUPER 550.8 +0.5 522 2.2 SIN3A DMAP1 ETS1 ZNF121 ZNF143 RUNX3 ZNF263 SP3 SP5 ATF4 CD99 XG
GH0XI002608 Promoter 1.2 Ensembl 11.3 -81.6 -81578 2.8 PKNOX1 SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SP3 SP5 GLIS1 CD99P1 MIR6089 CD99 LINC00102
GH0XI002630 Enhancer 0.8 Ensembl 12.1 -60.3 -60278 0.2 PKNOX1 ZBTB40 EGR1 E2F8 ETV6 CREM MIXL1 HCFC1 ZBTB11 CEBPB CD99 LINC00102 CD99P1 GC0XP002664
GH0XI002631 Enhancer 0.8 Ensembl 12.1 -59.8 -59778 0.4 HDAC1 PKNOX1 ATF1 NFRKB ZBTB40 E2F8 ETV6 CREM ZNF214 MIXL1 CD99 LINC00102 CD99P1 GC0XP002664
GH0XI002711 Enhancer 0.6 dbSUPER 12.8 +22.8 22770 4.2 HDGF ZNF282 FOXA2 ZSCAN26 ARNT ZSCAN4 MNT ZFHX2 LCORL NBN CD99 XG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD99 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD99 gene promoter:

Genomic Locations for CD99 Gene

Genomic Locations for CD99 Gene
chrX:2,691,179-2,741,309
(GRCh38/hg38)
Size:
50,131 bases
Orientation:
Plus strand
chrX:2,609,220-2,659,350
(GRCh37/hg19)

Genomic View for CD99 Gene

Genes around CD99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99 Gene

Proteins for CD99 Gene

  • Protein details for CD99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14209-CD99_HUMAN
    Recommended name:
    CD99 antigen
    Protein Accession:
    P14209
    Secondary Accessions:
    • A6NIW1
    • O00518
    • Q6ICV7

    Protein attributes for CD99 Gene

    Size:
    185 amino acids
    Molecular mass:
    18848 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Alternative splice isoforms for CD99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD99 Gene

Post-translational modifications for CD99 Gene

No data available for DME Specific Peptides for CD99 Gene

Domains & Families for CD99 Gene

Gene Families for CD99 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD99 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14209

UniProtKB/Swiss-Prot:

CD99_HUMAN :
  • Belongs to the CD99 family.
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99: view

Function for CD99 Gene

Molecular function for CD99 Gene

UniProtKB/Swiss-Prot Function:
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

Gene Ontology (GO) - Molecular Function for CD99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20374249
genes like me logo Genes that share ontologies with CD99: view
genes like me logo Genes that share phenotypes with CD99: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD99

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD99 Gene

Localization for CD99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD99 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
golgi apparatus 2
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2479542
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2465491
GO:0005925 focal adhesion IDA,HDA 21423176
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD99: view

Pathways & Interactions for CD99 Gene

genes like me logo Genes that share pathways with CD99: view

Pathways by source for CD99 Gene

Gene Ontology (GO) - Biological Process for CD99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD99: view

No data available for SIGNOR curated interactions for CD99 Gene

Drugs & Compounds for CD99 Gene

(1) Drugs for CD99 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CD99 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD99: view

Transcripts for CD99 Gene

Unigene Clusters for CD99 Gene

CD99 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD99

Alternative Splicing Database (ASD) splice patterns (SP) for CD99 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for CD99 Gene

GeneLoc Exon Structure for
CD99
ECgene alternative splicing isoforms for
CD99

Expression for CD99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD99 Gene

This gene is overexpressed in Adrenal (18.0) and Urine (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD99 Gene



Protein tissue co-expression partners for CD99 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD99 Gene:

CD99

SOURCE GeneReport for Unigene cluster for CD99 Gene:

Hs.653349

Evidence on tissue expression from TISSUES for CD99 Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Skin(4.7)
  • Liver(4.6)
  • Kidney(4.5)
  • Pancreas(4.3)
  • Lung(4)
  • Intestine(3.9)
  • Eye(3.2)
  • Stomach(3.1)
  • Muscle(3)
  • Bone(2.6)
  • Lymph node(2.5)
  • Bone marrow(2.3)
  • Heart(2.3)
  • Gall bladder(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CD99: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD99 Gene

Orthologs for CD99 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615666 33
  • 99.28 (n)
CD99 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD99 33 34
  • 70.7 (n)
dog
(Canis familiaris)
Mammalia CD99 33 34
  • 68.64 (n)
oppossum
(Monodelphis domestica)
Mammalia CD99 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD99 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD99 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD99 34
  • 46 (a)
OneToOne
Species where no ortholog for CD99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD99 Gene

ENSEMBL:
Gene Tree for CD99 (if available)
TreeFam:
Gene Tree for CD99 (if available)

Paralogs for CD99 Gene

(1) SIMAP similar genes for CD99 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CD99 Gene

genes like me logo Genes that share paralogs with CD99: view

No data available for Paralogs for CD99 Gene

Variants for CD99 Gene

Sequence variations from dbSNP and Humsavar for CD99 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000037782 -- 2,702,263(+) C/G intron_variant
rs1000332763 -- 2,716,426(+) G/A intron_variant
rs1000448757 -- 2,716,259(+) T/C intron_variant
rs1000565681 -- 2,712,268(+) A/G intron_variant
rs1000641608 -- 2,722,885(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD99 Gene

Variant ID Type Subtype PubMed ID
esv2752318 CNV gain 17911159
esv2758855 CNV gain 17122850
esv29994 CNV gain 17803354
esv29996 CNV loss 17803354
esv34985 CNV gain 17911159
nsv1115922 CNV duplication 24896259

Variation tolerance for CD99 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99 Gene

Disorders for CD99 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CD99 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
extraosseous ewing's sarcoma
  • extraosseous ewing sarcoma
ewing sarcoma
  • es
onychomatricoma
testicular fibroma
thymic epithelial tumor
  • epithelial tumor of thymus
- elite association - COSMIC cancer census association via MalaCards
Search CD99 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD99

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD99: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD99 Gene

Publications for CD99 Gene

  1. XG: the forgotten blood group system. (PMID: 22356523) Johnson NC (Immunohematology 2011) 2 3 58
  2. Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. (PMID: 19723899) Burkhardt J … Ahnert P (The Journal of rheumatology 2009) 3 44 58
  3. The association between CD99 and LMP-1 expression in nasopharyngeal carcinoma. (PMID: 16614706) Kim HS … Park CS (Experimental oncology 2006) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. (PMID: 14744088) Mahmood MN … Lee MW (Journal of cutaneous pathology 2003) 3 22 58

Products for CD99 Gene

  • Addgene plasmids for CD99

Sources for CD99 Gene

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