Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD99 Gene

protein-coding   GIFtS: 62
GCID: GC0XP002602

CD99 molecule

(Previous names: antigen identified by monoclonal antibodies 12E7, F21 and...)
(Previous symbol: MIC2)
 Explore 70 diseases affiliated with
CD99 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD99    

Aliases
for CD99 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD99 Molecule1 2     HBA712
MIC21 2 3 5     MSK5X2
CD99 Antigen1 2 3     Antigen Identified By Monoclonal 12E7, Y Homolog2
MIC2X2 3 5     MIC2 (Monoclonal Antibody 12E7)2
Antigen Identified By Monoclonal Antibodies 12E7, F21 And O131 2     Surface Antigen MIC22
MIC2Y2 3     12E73
E2 Antigen2 3     Protein MIC23
T-Cell Surface Glycoprotein E22 3     

External Ids:    HGNC: 70821   Entrez Gene: 42672   Ensembl: ENSG000000025867   OMIM: 3134705   UniProtKB: P142093   

Export aliases for CD99 gene to outside databases

Previous GC identifers: GC0XP001778 GC0XP002139 GC0XP002204 GC0YP002602 GC0XP000550


Summaries
for CD99 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD99:
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion,
ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition,
the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in
osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the
pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD99_HUMAN, P14209
Function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in
a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the
same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity)

Gene Wiki entry for CD99


Genomic Views
for CD99 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.1  NT_167197.1  NT_167205.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD99 gene promoter:
         c-Fos   AP-1   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD99 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD99

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD99


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.32 and Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.32 and Yp11.3

CD99 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD99 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP002602:  view genomic region     (about GC identifiers)

Start:
 2,609,220 bp from pter      End:
 2,659,350 bp from pter
Size:
 50,131 bases      Orientation:
 plus strand

1 alternative location:
ChrY+ 2,559,228-2,609,350     

Proteins
for CD99 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD99_HUMAN, P14209 (See protein sequence)
Recommended Name: CD99 antigen precursor  
Size: 185 amino acids; 18848 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: A6NIW1 O00518 Q6ICV7
Alternative splicing: 3 isoforms:  P14209-1   P14209-2   P14209-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD99: NX_P14209

Post-translational modifications:

  • Extensively O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14209

    • CD99 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116370.1  NP_002405.1  

    ENSEMBL proteins: 
     ENSP00000370588   ENSP00000370582   ENSP00000370579   ENSP00000370573   ENSP00000405544  
     ENSP00000370570  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD99
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): CD99
    OriGene Custom Protein Services for CD99 
    GenScript Custom Purified and Recombinant Proteins Services for CD99
    Novus Biologicals CD99 Proteins
    Novus Biologicals CD99 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CD99
    Uscn Proteins for CD99

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS2479542
    GO:0005886plasma membrane TAS2465491
    GO:0005887integral to plasma membrane TAS2479542


    CD99 for ontologies           About GeneDecksing



    CD99 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD99
    OriGene Antibodies (see all 10): CD99
    OriGene Custom Antibody Services for CD99 
    GenScript Custom Superior Antibodies Services for CD99
    Novus Biologicals CD99 Antibodies
    Abcam antibodies for CD99 
    Uscn Antibodies for CD99
    ThermoFisher Antibody for CD99

    Assay Products for CD99: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for CD99
    GenScript Custom Assay Services for CD99
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CD99

    Protein Domains /
    Families
    for CD99 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD99 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR022078 CD99L2

    Graphical View of Domain Structure for InterPro Entry P14209

    ProtoNet protein and cluster: P14209

    UniProtKB/Swiss-Prot: CD99_HUMAN, P14209
    Similarity: Belongs to the CD99 family


    Function
    for CD99 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD99_HUMAN, P14209
    Function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in
    a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the
    same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): CD99
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD99
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD99
    SwitchGear 3'UTR luciferase reporter plasmid: CD99 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD99
    OriGene shRNA RFP: CD99
    OriGene siRNA: CD99
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD99

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD99

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD99 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD99 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD99 (NM_002414)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD99
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD99 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD99
    Search LifeMap BioReagents cell lines for CD99

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD99

    4 GenomeRNAi human phenotypes for CD99:
     Actin fiber cells  G0/1 arrest  Increased G1 DNA content  Increased cell size 


    Pathways & Interactions
    for CD99 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00
    2Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00
    3Integrin Pathway
    		Transendothelial Migration of Leukocytes0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CD99
        Transendothelial Migration of Leukocytes


    2         Kegg Pathways  (Kegg details for CD99):
        Cell adhesion molecules (CAMs)
    Leukocyte transendothelial migration


    CD99 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD99

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for CD99 (P142092, 3 ENSP000003705884) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-67309 I2D: score=5 STRING: ENSP00000365576
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2860903 I2D: score=3 STRING: ENSP00000357292
    ANXA2P073553, ENSP000003460324I2D: score=3 STRING: ENSP00000346032
    PPIAP629373, ENSP000004194254I2D: score=3 STRING: ENSP00000419425
    KPNB1Q149743, ENSP000002901584I2D: score=2 STRING: ENSP00000290158
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    CD99 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD99 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD99 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD99
    3 Novoseek chemical compound relationships for CD99 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 18.5 5 9343323 (4)
    phosphatidylserine 13.7 2 8399135 (2)
    vegf 0 3 17571460 (3)

    Search CenterWatch for drugs/clinical trials and news about CD99 

    Transcripts
    for CD99 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD99 gene (2 alternative transcripts): 
    NM_001122898.1  NM_002414.3  

    Unigene Cluster for CD99:

    CD99 molecule
    Hs.653349  [show with all ESTs]
    Unigene Representative Sequence: BF341535
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381192(uc004cqm.3 uc010nda.3 uc004cqn.3) ENST00000381187
    ENST00000381184 ENST00000381180 ENST00000449611 ENST00000482293 ENST00000497752
    ENST00000482405 ENST00000381177

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CD99
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD99
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD99
    SwitchGear 3'UTR luciferase reporter plasmid: CD99 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD99
    OriGene shRNA RFP: CD99
    OriGene siRNA: CD99
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD99
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD99 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD99 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD99 (NM_002414)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD99
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD99 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD99
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD99
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD99
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD99

    Additional cDNA sequence: 

    AK309517.1 AK313617.1 BC002584.2 BC003147.1 BC010109.2 BC021620.1 BC024310.1 CR450286.1 
    M16279.1 U82164.1 X16996.1 

    24/55 DOTS entries (see all 55):

    DT.100882403  DT.95269792  DT.100882412  DT.40208580  DT.120654807  DT.121277500  DT.100811686  DT.75190973 
    DT.100882404  DT.99931808  DT.101968474  DT.95269789  DT.100882411  DT.102834185  DT.100882391  DT.120654775 
    DT.100837765  DT.120654790  DT.120654796  DT.121277568  DT.100882395  DT.91685405  DT.91769523  DT.95269779 

    24/696 AceView cDNA sequences (see all 696):

    CB216730 AA311054 CR599137 BC024310 BM741339 CR611995 AW583215 BC002584 
    BM671093 AI740443 CR611199 CD364997 CR610873 BQ776508 T51103 BM785552 
    CR605688 CR606510 AL551252 BQ226154 CA441742 CR598638 CK819227 BM687037 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD99 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:                          -                                               -     -                                 
    SP2:                          -                                               -     -                                 
    SP3:                          -                                                                                       
    SP4:                          -                                               -                                       
    SP5:                          -     -                                         -     -                                 


    ECgene alternative splicing isoforms for CD99

    Expression
    for CD99 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD99 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATGTGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CD99 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD99

    SOURCE GeneReport for Unigene cluster: Hs.653349
        SABiosciences Expression via Pathway-Focused PCR Array including CD99: 
              Tight Junctions in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD99
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD99
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD99
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD99
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD99

    Orthologs
    for CD99 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD99 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CD991 CD99 molecule 57.81(n)
    49.65(a)    		   418662  NM_001198651.1  NP_001185580.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cd996
    		 CD99 molecule
    		 28(a)
    		 1 ↔ 1
    		 1(33020650-33045276)


    ENSEMBL Gene Tree for CD99 (if available)
    TreeFam Gene Tree for CD99 (if available) 

    Paralogs
    for CD99 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD99 gene
    CD99L22  
    1 SIMAP similar gene for CD99 using alignment to 5 protein entries:     CD99_HUMAN (see all proteins):
    CD99L2

    CD99 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD99
    PGOHUM00000241627


    Genomic Variants
    for CD99 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CD99
         4 CNVs: 8293 23329 8292 4142
    Locus Specific Mutation Databases (LSDB): CD99
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD99
    DNA2.0 Custom Variant and Variant Library Synthesis for CD99

    Disorders / Diseases
    for CD99 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD99 for disorders           About GeneDecksing

    OMIM gene information: 313470    OMIM disorders: --

    20/70 diseases for CD99 (see all 70):    About MalaCards
    osteosarcoma    primitive neuroectodermal tumor    desmoplastic small round cell tumor    supratentorial primitive neuroectodermal tumor
    extraosseous ewing's sarcoma    small cell osteogenic sarcoma    peripheral primitive neuroectodermal tumor    spindle cell lipoma
    central nervous system cancer    neuroectodermal tumors    pulmonary vein stenosis    anaplastic large cell lymphoma
    chondrodysplasia punctata    esthesioneuroblastoma    non-hodgkin lymphoma    testicular fibroma
    thymic epithelial tumor    fibrous histiocytoma    x inactivation    b-cell lymphomas

    7 diseases from the University of Copenhagen DISEASES database for CD99:
    Peripheral primitive neuroectodermal tumor     Primitive neuroectodermal tumor     Sarcoma     Testicular fibroma
    Synovial sarcoma     Small cell osteogenic sarcoma     Rhabdomyosarcoma

    10/20 Novoseek disease relationships for CD99 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peripheral neuroepithelioma 85.8 1 1848471 (1)
    ewings sarcoma 84.3 19 8150461 (5), 1848471 (3), 8163272 (2), 12724079 (1) (see all 11)
    sarcoma extraosseous ewings 71.7 2 12400989 (1)
    lymphoma lymphoblastic 61.6 4 8163272 (2), 9343323 (1)
    esthesioneuroblastoma 60.4 1 12724079 (1)
    rhabdomyosarcoma 41.8 1 8163272 (1)
    tumors 41.2 38 8150461 (4), 7627931 (3), 1848471 (2), 1988096 (2) (see all 23)
    stromal tumors 40.1 2 10374776 (1)
    hepatitis c 32 2 7689528 (1)
    epithelial tumor 25 4 10374776 (2)

    Human Genome Epidemiology (HuGE) Navigator: CD99 (1 document)

    Export disorders for CD99 gene to outside databases

    Publications
    for CD99 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD99 gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with CD99)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. (PubMed id 2479542)1, 2 Gelin C....Bernard A. (1989)
    3. Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome. (PubMed id 2456574)1, 2 Goodfellow P.J....Goodfellow P.N. (1988)
    4. Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes. (PubMed id 3472717)1, 2 Darling S.M....Goodfellow P.N. (1986)
    5. The association between CD99 and LMP-1 expression in nasopharyngeal carcinoma. (PubMed id 16614706)1, 9 Kim H.S....Park C.S. (2006)
    6. Quantitative analysis of XG blood group and CD99 antigens on human red cells. (PubMed id 10941840)1, 9 Fouchet C....Lopez C. (2000)
    7. Flow cytometric assessment of human MIC2 expression in bone marrow, thymus, and peripheral blood. (PubMed id 7506950)1, 9 Dworzak M.N....Gadner H. (1994)
    8. Immunoreactivity of CD99 in stomach cancer. (PubMed id 12172043)1, 9 Jung K.C....Park S.H. (2002)
    9. Engagement of CD99 triggers the exocytic transport of ganglioside GM1 and the reorganization of actin cytoskeleton. (PubMed id 12681511)1, 9 Yoon S.S....Kim T.J. (2003)
    10. Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. (PubMed id 14744088)1, 9 Mahmood M.N....Lee M.W. (2003)

    External Searches for CD99 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD99 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4267 HGNC: 7082 AceView: CD99 Ensembl:ENSG00000002586 euGenes: HUgn4267
    ECgene: CD99 Kegg: 4267 H-InvDB: CD99

    Other Databases showing CD99 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD99 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD99 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD99 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CD99 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD99 gene:
    Search GeneIP for patents involving CD99

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CD99 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD99 (CD99)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for CD99 (CD99)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CD99 (CD99)  
     OriGene Antibodies for CD99   OriGene shRNA RFP for CD99  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD99   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD99  
     OriGene Protein Over-expression Lysate for CD99   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CD99   OriGene 3'-UTR Clone for CD99  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD99   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD99  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD99   OriGene Custom Protein Services for CD99  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD99
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD99
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD99
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD99
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD99
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD99
     GenScript Custom Purified and Recombinant Proteins Services for CD99 GenScript cDNA clones with any tag delivered in your preferred vector for CD99
     GenScript Custom Assay Services for CD99 GenScript Custom Superior Antibodies Services for CD99
     GenScript Custom overexpressing Cell Line Services for CD99 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD99 promoter
     Search Chromatin IP Primers for CD99
     RT2 qPCR Primer Assay in human, mouse / rat CD99
     GNC Network for CD99
     SABiosciences PCR Arrays including human, mouse / rat CD99
     Search Tocris compounds for CD99
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD99 antibodies
     CD99 proteins
     CD99 lysates
     Antibodies for CD99
     See all of Abcam's Antibodies, Kits and Proteins for CD99
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CD99




     CD99 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CD99
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD99
     SwitchGear 3'UTR luciferase reporter plasmids for CD99
     SwitchGear Promoter luciferase reporter plasmids for CD99
     ThermoFisher Antibody for CD99
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD99
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CD99 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4