Aliases for CD99 Gene
External Ids for CD99 Gene
Previous Symbols for CD99 Gene
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]
GeneCards Summary for CD99 Gene
CD99 (CD99 Molecule) is a Protein Coding gene. Diseases associated with CD99 include juvenile type testicular granulosa cell tumor and testicular granulosa cell tumor. Among its related pathways are Integrin Pathway and Leukocyte transendothelial migration.
UniProtKB/Swiss-Prot for CD99 Gene
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).