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CD97 Gene

protein-coding   GIFtS: 68
GCID: GC19P014492

CD97 Molecule

(Previous name: CD97 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD97 Molecule1 2     Heterodimeric Receptor Associated With Inflammation1
CD97 Antigen1 2 3     seven-transmembrane1
Leukocyte Antigen CD971 2 3     TM7LN12
Seven Transmembrane Helix Receptor1 2     Seven-Transmembrane, Heterodimeric Receptor Associated With Inflammation2
Seven-Span Transmembrane Protein1 2     

External Ids:    HGNC: 17111   Entrez Gene: 9762   Ensembl: ENSG000001231467   OMIM: 6012115   UniProtKB: P489603   
ORGUL members:         

Export aliases for CD97 gene to outside databases

Previous GC identifers: GC19P014847 GC19P014336 GC19P014353 GC19P014062


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD97 Gene:
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate
cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular
subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The
encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and
contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell
surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several
types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like
repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short
arm of chromosome 19. (provided by RefSeq, Jun 2011)

GeneCards Summary for CD97 Gene:
CD97 (CD97 molecule) is a protein-coding gene. Diseases associated with CD97 include pulmonary embolism, and gaucher's disease. GO annotations related to this gene include transmembrane signaling receptor activity and calcium ion binding. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: CD97_HUMAN, P48960
Function: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation.
Plays an essential role in leukocyte migration (By similarity)

Gene Wiki entry for CD97 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD97 gene promoter:
         ISGF-3   RFX1   AML1a   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD97 promoter sequence
   Search Chromatin IP Primers for CD97

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13

CD97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD97 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014492:  view genomic region     (about GC identifiers)

Start:
14,491,313 bp from pter      End:
14,519,537 bp from pter
Size:
28,225 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD97_HUMAN, P48960 (See protein sequence)
Recommended Name: CD97 antigen precursor  
Size: 835 amino acids; 91869 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to
a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The
largest isoform (isoform 1) interacts with chondroitin sulfate
Sequence caution: Sequence=AAC27673.1; Type=Erroneous gene model prediction; Sequence=BAC06178.1; Type=Erroneous
gene model prediction;
Secondary accessions: A8K7Z4 B2RBJ9 O00718 O76101 Q8NG72 Q8TBQ7
Alternative splicing: 3 isoforms:  P48960-1   P48960-2   P48960-3   

Explore the universe of human proteins at neXtProt for CD97: NX_P48960

Explore proteomics data for CD97 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By
    similarity)1
  • Glycosylation2 at Asn33, Asn38, Asn108, Asn203, Asn371, Asn406, Asn413, Asn453, Asn520
  • Modification sites at PhosphoSitePlus

  • See CD97 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020331.1  NP_001775.2  NP_510966.1  

    ENSEMBL proteins: 
     ENSP00000351413   ENSP00000465800   ENSP00000467351   ENSP00000466040   ENSP00000349918  
     ENSP00000467478   ENSP00000242786  
    Reactome Protein details: P48960

    CD97 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals CD97 Proteins
    Novus Biologicals CD97 Lysates
    Sino Biological Recombinant Protein for CD97
    Sino Biological Cell Lysate for CD97
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD97

    CD97 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD97
    R&D Systems Antibodies for CD97
    OriGene Antibodies for CD97
    OriGene Custom Antibody Services for CD97
    Novus Biologicals CD97 Antibodies
    Abcam antibodies for CD97
    Cloud-Clone Corp. Antibodies for CD97
    ThermoFisher Antibody for CD97
    LSBio Antibodies in human, mouse, rat for CD97

    CD97 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CD97         (see all)
    GenScript Custom Assay Services for CD97
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD97
    Cloud-Clone Corp. CLIAs for CD97


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD97
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR000832 GPCR_2_secretin-like
     IPR003056 GPCR_2_CD97

    Graphical View of Domain Structure for InterPro Entry P48960

    ProtoNet protein and cluster: P48960

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001881 EGF-like calcium-binding
    IPB003056 CD97 protein signature


    UniProtKB/Swiss-Prot: CD97_HUMAN, P48960
    Domain: The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is
    necessary for the structural integrity of the binding region
    Domain: Binding to chondroitin sulfate is mediated by the fourth EGF domain
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 GPS domain


    CD97 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD97_HUMAN, P48960
    Function: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation.
    Plays an essential role in leukocyte migration (By similarity)
    Induction: Rapid up-regulation during lymphocyte activation

         Genatlas biochemistry entry for CD97:
    cell differentiation antigen CD97 (75/85kDa),leukocyte membrane glycoprotein,identified by monoclonal antibodies
    BL-Ac/F2,VIM3,VIM3B,VIM3C

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7636245
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI9064337
         
    CD97 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cd97):
     hematopoietic system  immune system  mortality/aging  no phenotypic analysis  normal 

    CD97 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD97: Cd97tm1Kake Cd97tm1.1Joha

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD97
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD97

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD97
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD97

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD97:
    hsa-mir-484 (MIRT042273), hsa-mir-26b-5p (MIRT029344), hsa-mir-16-5p (MIRT031599)

    Block miRNA regulation of human, mouse, rat CD97 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CD97:
    hsa-miR-505 hsa-miR-320a hsa-miR-320b hsa-miR-622 hsa-miR-2114* hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidCD97 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD97
    Predesigned siRNA for gene silencing in human, mouse, rat CD97

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD97

    Clone
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    OriGene clones in human, mouse for CD97 (see all 21)
    OriGene ORF clones in mouse, rat for CD97
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD97 (NM_078481)
    Sino Biological Human cDNA Clone for CD97
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD97
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD97

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD97 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD97


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD97_HUMAN, P48960: Cell membrane; Multi-pass membrane protein
    CD97_HUMAN, P48960: CD97 antigen subunit alpha: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8955192
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    CD97 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD97 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    2Peptide ligand-binding receptors
    GPCR ligand binding0.71
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD97
        GPCRs, Class B Secretin-like


    1 Reactome Pathway for CD97
        Class B/2 (Secretin family receptors)



    CD97 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD97: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD97

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CD97 (P489602, 3 ENSP000002427864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129312, 3, ENSP000003509414MINT-8112915 I2D: score=3 STRING: ENSP00000350941
    CD55P081743, ENSP000003163334I2D: score=2 STRING: ENSP00000316333
    EMR2ENSP000003198834STRING: ENSP00000319883
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS7636245
    GO:0006954inflammatory response TAS8955192
    GO:0006955immune response TAS7636245
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway TAS7636245

    CD97 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD97

    1 HMDB Compound for CD97    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--

    4 Novoseek inferred chemical compound relationships for CD97 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 44.9 6 15498814 (3), 15693006 (1)
    dermatan sulfate 43.3 3 15693006 (2), 17007638 (1)
    retinoic acid 20.9 7 10084602 (2), 15668483 (1)
    sodium 0 2 10884186 (1), 12414513 (1)



    CD97 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD97 gene (3 alternative transcripts): 
    NM_001025160.2  NM_001784.4  NM_078481.3  

    Unigene Cluster for CD97:

    CD97 molecule
    Hs.466039  [show with all ESTs]
    Unigene Representative Sequence: NM_078481
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587728 ENST00000358600(uc002myn.3) ENST00000587535 ENST00000587606
    ENST00000586517 ENST00000591080 ENST00000357355(uc002mym.3) ENST00000592261
    ENST00000242786(uc002myl.3) ENST00000591737 ENST00000593028 ENST00000586849
    ENST00000590567 ENST00000587319 ENST00000592341 ENST00000591565
    miRNA
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    Block miRNA regulation of human, mouse, rat CD97 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CD97:
    hsa-miR-505 hsa-miR-320a hsa-miR-320b hsa-miR-622 hsa-miR-2114* hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidCD97 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD97
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD97 (NM_078481)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD97
    Primer
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    OriGene qPCR primer pairs and template standards for CD97
    OriGene qSTAR qPCR primer pairs in human, mouse for CD97
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD97
      QuantiTect SYBR Green Assays in human, mouse, rat CD97
      QuantiFast Probe-based Assays in human, mouse, rat CD97

    Additional mRNA sequence: 

    AK097264.1 AK225655.1 AK225677.1 AK292159.1 AK300343.1 AK304553.1 AK308368.1 AK314697.1 
    BC026690.2 U76764.1 X84700.1 

    Selected DOTS entries (see all 27):

    DT.445962  DT.100825502  DT.100659503  DT.100825500  DT.95237047  DT.92457869  DT.121497172  DT.40219200 
    DT.121497168  DT.100825501  DT.101965354  DT.121497181  DT.95237053  DT.95345709  DT.92457874  DT.95125784 
    DT.95267392  DT.97805437  DT.100825494  DT.101961893  DT.121497137  DT.121504100  DT.302471  DT.91999306 

    Selected AceView cDNA sequences (see all 244):

    AI800079 AU133159 CB127827 AI813771 BG680085 BM765956 BQ879927 X84700 
    BG818760 BM766013 AI571102 CA454989 BX644508 AW103713 AX775813 AI865565 
    BQ217379 NM_078481 BF342881 BM766196 BM791825 BU627555 CA453936 BQ224857 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD97 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                      -                                               -                                                                     
    SP2:                                      -     -     -                                   -                                                                     
    SP3:                                      -           -                                   -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for CD97

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD97 expression in normal human tissues (normalized intensities)      CD97 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACAGAAA
    CD97 Expression
    About this image


    CD97 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CD97 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD97 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466039

    UniProtKB/Swiss-Prot: CD97_HUMAN, P48960
    Tissue specificity: Broadly expressed, found on most hematopoietic cells, including activated lymphocytes,
    monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells.
    Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased
    under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid
    arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in
    the synovial fluid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD97: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD97
    OriGene qSTAR qPCR primer pairs in human, mouse for CD97
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD97
    QuantiTect SYBR Green Assays in human, mouse, rat CD97
    QuantiFast Probe-based Assays in human, mouse, rat CD97
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD97

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD97 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd971 , 5 CD97 antigen1, 5 70(n)1
    61.17(a)1
      8 (40.22 cM)5
    263641  NM_011925.21  NP_036055.21 
     837232515 
    lizard
    (Anolis carolinensis)
    Reptilia CD976
    CD97 molecule
    38(a)
    1 ↔ 1
    2(118814120-118876266)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cd971 CD97 molecule 51.09(n)
    42.71(a)
      100490425  XM_002935418.2  XP_002935464.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005366571 EGF-like module-containing mucin-like hormone receptor-like more 50.8(n)
    42.09(a)
      100536657  XM_003197787.2  XP_003197835.2 


    ENSEMBL Gene Tree for CD97 (if available)
    TreeFam Gene Tree for CD97 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD97 gene
    GPR972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  EMR22  
    GPR1332  GPR1122  GPR1442  EMR32  GPR562  GPR1262  GPR642  
    4 SIMAP similar genes for CD97 using alignment to 5 protein entries:     CD97_HUMAN (see all proteins):
    EMR2    NELL2    EMR1    UMOD

    CD97 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD97 (see all 860)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841232481,2
    --14425920(+) CCAGAA/G/TCTGGT 3 -- us2k10--------
    rs1872052351,2
    --14425991(+) ACCCCA/CACAGG 3 -- us2k10--------
    rs1381487641,2
    --14426045(+) GATTAC/TTCCCA 3 -- us2k10--------
    rs1154714021,2
    F--14426075(+) TCAGTG/CATTAG 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1168280401,2
    F--14426091(+) TTTTTT/ACCCCA 3 -- us2k11Minor allele frequency- A:0.02WA 118
    rs104090931,2
    C,F,A--14426303(+) CTGGAC/TACAGA 3 -- us2k14Minor allele frequency- T:0.37NA CSA WA 124
    rs1921282761,2
    --14426336(+) CGGAGA/GCGCTA 3 -- us2k10--------
    rs1844729361,2
    --14426348(+) AGACAC/TGTTAG 3 -- us2k10--------
    rs116670421,2
    C,F,A,H--14426362(+) CCAGTG/AGAGAC 3 -- us2k18Minor allele frequency- A:0.47NA WA EA 368
    rs104076711,2
    C,F,H--14426378(+) CCTGGG/ACTCAT 3 -- us2k19Minor allele frequency- A:0.02NS EA NA 1086

    HapMap Linkage Disequilibrium report for CD97 (14491313 - 14519537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD97:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666679CNV Deletion23128226
    nsv911121CNV Loss21882294
    nsv833764CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601211    OMIM disorders: --

    Selected diseases for CD97 (see all 28):    About MalaCards
    pulmonary embolism    gaucher's disease    pancreatic ductal adenocarcinoma    thyroid cancer
    wilms tumor    oral squamous cell carcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    arthritis    thyroiditis    osteoarthritis    cervical cancer
    rheumatoid arthritis    multiple sclerosis    malignant glioma    cervicitis
    adenocarcinoma    tonsillitis    atherosclerosis    squamous cell carcinoma


    CD97 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD97 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 54.5 9 10084602 (4), 12428789 (1), 10884186 (1)
    thyroid carcinoma anaplastic 53.5 1 10084602 (1)
    arthritis reactive 45.4 1 10211878 (1)
    colorectal tumors 39.2 1 12414513 (1)
    colorectal carcinoma 32 4 12414513 (2), 12761622 (2)
    aggressiveness 25.4 2 12414513 (1), 16130195 (1)
    tumors 24.5 34 20339853 (7), 12414513 (5), 12428789 (3), 12761622 (3) (see all 13)
    rheumatoid arthritis 16.9 2 11037979 (1), 10211878 (1)
    adenocarcinoma 14.8 7 20339853 (3), 11940212 (2), 12414513 (1), 12761622 (1)
    carcinoma 11.2 7 12414513 (2), 16408199 (1), 15576472 (1), 14719104 (1) (see all 5)

    Genetic Association Database (GAD): CD97
    Human Genome Epidemiology (HuGE) Navigator: CD97 (5 documents)

    Export disorders for CD97 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD97 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with CD97)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. (PubMed id 7636245)1, 2, 3, 9 Hamann J.... van Lier R.A.W. (J. Immunol. 1995)
    2. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. (PubMed id 8786105)1, 2, 3, 9 Hamann J.... van Lier R.A.W. (Genomics 1996)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The EGF-TM7 family: a postgenomic view. (PubMed id 14647991)1, 2 Kwakkenbos M.J....Hamann J. (Immunogenetics 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. (PubMed id 12829604)1, 2 Stacey M.... Lin H.-H. (Blood 2003)
    9. Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. (PubMed id 11297558)1, 2 Lin H.-H.... Lea S. (J. Biol. Chem. 2001)
    10. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. (PubMed id 8955192)1, 2 Gray J.X.... Kelly K. (J. Immunol. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 976 HGNC: 1711 AceView: CD97 Ensembl:ENSG00000123146 euGenes: HUgn976
    ECgene: CD97 H-InvDB: CD97

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD97 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD97 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD97 gene:
    Search GeneIP for patents involving CD97

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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