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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD97 Gene

protein-coding GIFtS: 64
GCID: GC19P014492

CD97 molecule

(Previous name: CD97 antigen )

Explore 28 diseases affiliated with
CD97 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD97 Molecule¹ ²		Seven Transmembrane Helix Receptor²
CD97 Antigen¹ ² ³		Seven-Span Transmembrane Protein²
TM7LN1¹ ²		Seven-Transmembrane, Heterodimeric Receptor Associated With Inflammation²
Leukocyte Antigen CD97² ³

External Ids:	HGNC: 1711¹	Entrez Gene: 976²	Ensembl: ENSG00000123146⁷	OMIM: 601211⁵	UniProtKB: P48960³

Export aliases for CD97 gene to outside databases

Previous GC identifers: GC19P014847 GC19P014336 GC19P014353 GC19P014062

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD97:

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell

interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and

seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may

play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple

extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory

protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively

spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene.

This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. (provided by RefSeq, Jun

2011)

UniProtKB/Swiss-Prot: CD97_HUMAN, P48960

Function: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation.

Plays an essential role in leukocyte migration (By similarity)

Gene Wiki entry for CD97

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD97 gene promoter:
ISGF-3 RFX1 AML1a NRSF form 1 Pax-2 Pax-2a NRSF form 2 MEF-2A aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD97 promoter sequence

Search SABiosciences Chromatin IP Primers for CD97

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD97

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13

CD97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD97 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P014492: view genomic region (about GC identifiers)

Start:	14,491,313 bp from pter	End:	14,519,537 bp from pter
Size:	28,225 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD97_HUMAN, P48960 (See protein sequence)

Recommended Name: CD97 antigen precursor

Size: 835 amino acids; 91869 Da

Subunit: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a

seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest

isoform (isoform 1) interacts with chondroitin sulfate

Subcellular location: Cell membrane; Multi-pass membrane protein

Subcellular location: CD97 antigen subunit alpha: Secreted, extracellular space

Sequence caution: Sequence=AAC27673.1; Type=Erroneous gene model prediction; Sequence=BAC06178.1; Type=Erroneous gene

model prediction;

Secondary accessions: A8K7Z4 B2RBJ9 O00718 O76101 Q8NG72 Q8TBQ7

Alternative splicing: 3 isoforms: P48960-1 P48960-2 P48960-3

Explore the universe of human proteins at neXtProt for CD97: NX_P48960

Post-translational modifications:

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48960

CD97 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001020331.1 NP_001775.2 NP_510966.1

ENSEMBL proteins:

ENSP00000351413 ENSP00000465800 ENSP00000467351 ENSP00000466040 ENSP00000349918

ENSP00000467478 ENSP00000242786

Reactome Protein details: P48960
Human Recombinant Protein Products for CD97:

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	Novus Biologicals CD97 Proteins Novus Biologicals CD97 Lysates
	Sino Biological Recombinant Protein for CD97
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD97

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8955192

CD97 for ontologies About GeneDecksing

CD97 Antibody Products:

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	ThermoFisher Antibody for CD97

Assay Products for CD97:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD97

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD97 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR000742 EG-like_dom

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

IPR000832 GPCR_2_secretin-like

IPR003056 GPCR_2_CD97

Graphical View of Domain Structure for InterPro Entry P48960

ProtoNet protein and cluster: P48960

5 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000203 GPS domain

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB001881 EGF-like calcium-binding

IPB003056 CD97 protein signature

UniProtKB/Swiss-Prot: CD97_HUMAN, P48960

Domain: The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary

for the structural integrity of the binding region

Domain: Binding to chondroitin sulfate is mediated by the fourth EGF domain

Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily

Similarity: Contains 5 EGF-like domains

Similarity: Contains 1 GPS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD97_HUMAN, P48960

Function: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation.

Plays an essential role in leukocyte migration (By similarity)

Induction: Rapid up-regulation during lymphocyte activation

Genatlas biochemistry entry for CD97:

cell differentiation antigen CD97 (75/85kDa),leukocyte membrane glycoprotein,identified by monoclonal antibodies

BL-Ac/F2,VIM3,VIM3B,VIM3C

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	7636245
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005509	calcium ion binding	IEA	--

CD97 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cd97):

hematopoietic system

immune system

mortality/aging

no phenotypic analysis

normal

CD97 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CD97: Cd97^tm1.1Joha Cd97^tm1Kake

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD97

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CD97 Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD97:
		hsa-miR-505 hsa-miR-320a hsa-miR-320b hsa-miR-622 hsa-miR-2114* hsa-miR-320d
		SwitchGear 3'UTR luciferase reporter plasmid: CD97 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD97 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD97 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD97

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

Signaling by GPCR

1.00

Signal Transduction

0.56

GPCRs, Class B Secretin-like

GPCRs, Class B Secretin-like

1.00

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CD97

GPCRs, Class B Secretin-like

4 Reactome Pathways for CD97

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

CD97 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD97

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for CD97 (P48960^{2, 3} ENSP00000242786⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRC	P12931²^,³, ENSP00000350941⁴	MINT-8112915 I2D: score=3 STRING: ENSP00000350941
CD55	P08174³, ENSP00000316333⁴	I2D: score=2 STRING: ENSP00000316333
EMR2	ENSP00000319883⁴	STRING: ENSP00000319883
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	7636245
GO:0006954	inflammatory response	TAS	8955192
GO:0006955	immune response	TAS	7636245
GO:0007155	cell adhesion	IEA	--
GO:0007166	cell surface receptor signaling pathway	TAS	7636245

CD97 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD97 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD97

1 HMDB Compound for CD97 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chondroitin	Chondroitin-D-glucuronate (see all 5)	9007-27-6	--

4 Novoseek chemical compound relationships for CD97 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin sulfate	44.9	6	15498814 (3), 15693006 (1)
dermatan sulfate	43.3	3	15693006 (2), 17007638 (1)
retinoic acid	20.9	7	10084602 (2), 15668483 (1)
sodium	0	2	10884186 (1), 12414513 (1)

Search CenterWatch for drugs/clinical trials and news about CD97

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD97 gene (3 alternative transcripts):

NM_001025160.2 NM_001784.4 NM_078481.3

Unigene Cluster for CD97:

CD97 molecule

Hs.466039 [show with all ESTs]

Unigene Representative Sequence: NM_078481

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000587728 ENST00000358600(uc002myn.3) ENST00000587535 ENST00000587606

ENST00000586517 ENST00000591080 ENST00000357355(uc002mym.3) ENST00000592261

ENST00000242786(uc002myl.3) ENST00000591737 ENST00000593028 ENST00000586849

ENST00000590567 ENST00000587319 ENST00000592341 ENST00000591565

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD97
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD97:
		hsa-miR-505 hsa-miR-320a hsa-miR-320b hsa-miR-622 hsa-miR-2114* hsa-miR-320d
		SwitchGear 3'UTR luciferase reporter plasmid: CD97 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD97 (see all 7) OriGene shRNA RFP: CD97 OriGene siRNA: CD97
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD97
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD97

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD97

Additional cDNA sequence:

AK097264.1 AK225655.1 AK225677.1 AK292159.1 AK300343.1 AK304553.1 AK308368.1 AK314697.1

BC026690.2 U76764.1 X84700.1

24/27 DOTS entries (see all 27):

DT.445962 DT.100825502 DT.100659503 DT.100825500 DT.95237047 DT.92457869 DT.121497172 DT.40219200

DT.121497168 DT.100825501 DT.101965354 DT.121497181 DT.95237053 DT.95345709 DT.92457874 DT.95125784

DT.95267392 DT.97805437 DT.100825494 DT.101961893 DT.121497137 DT.121504100 DT.302471 DT.91999306

24/244 AceView cDNA sequences (see all 244):

AI564271 BQ224857 BX644508 AI744373 CR601106 AU280770 BM769646 BU615933

BM766196 BU627555 AI571102 BM841858 BQ706458 BM765956 AI570153 CA454989

BM765985 BM766013 NM_078481 AU133159 AK097264 CA489465 BF342881 AW328733

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CD97 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:													-																-
SP2:													-		-		-												-
SP3:													-				-												-
SP4:
SP5:

ECgene alternative splicing isoforms for CD97

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD97 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATACAGAAA

About this image

CD97 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD97 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD97

SOURCE GeneReport for Unigene cluster: Hs.466039

UniProtKB/Swiss-Prot: CD97_HUMAN, P48960

Tissue specificity: Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes,

macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in

thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory

conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased

expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid

SABiosciences Expression via Pathway-Focused PCR Arrays including CD97:

G Protein Coupled Receptors 384HT in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD97 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD97

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD97

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD97 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CD97⁶	--	40(a)	1 ↔ 1	2(118814425-118840612)
zebrafish (Danio rerio)	Actinopterygii	LOC100536657¹	CD97 antigen-like	51.73(n) 42.76(a)		100536657 XM_003197787.1 XP_003197835.1
worm (Caenorhabditis elegans)	Secernentea	lat-2⁶ lat-1⁶	LATrophilin receptor family member (lat-1)	9(a) 13(a)	possible ortholog possible ortholog	II(4359086-4368285) II(8896780-8908592)

ENSEMBL Gene Tree for CD97 (if available)
TreeFam Gene Tree for CD97 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD97 gene

GPR97² ELTD1² LPHN1² LPHN2² GPR114² EMR1² LPHN3² EMR2²

GPR112² GPR133² GPR144² EMR3² GPR56² GPR126² GPR64²

4 SIMAP similar genes for CD97 using alignment to 5 protein entries: CD97_HUMAN (see all proteins):

EMR2 NELL2 EMR1 UMOD

CD97 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75739583^1,2		--	14089478(+)	`CCCTTG/CGGGCC`	3	--	ds500¹		1		CSA	2
rs45539937^1,2	C	--	14089682(+)	`GTGTCC/TGTGAA`	3	--	ds500¹		1		NA	2
rs75381848^1,2	C,F	--	14089781(+)	`GTGGCG/ACCTGG`	3	--	ut3¹ nc-transcript-variant		1		WA	118
rs112255397^1,2	C	--	14089946(+)	`ACTTAA/C/GTGTAT`	3	--	spd¹		1		CSA	1
rs112205992^1,2	C	--	14090096(+)	`CCACCA/C/TGCAGG`	3	--	spa¹		1		CSA	1
rs184123248^1,2		--	14489970(+)	`CCAGAA/G/TCTGGT`	3	--	us2k¹		0	--	--	--	--
rs187205235^1,2		--	14490041(+)	`ACCCCA/CACAGG`	3	--	us2k¹		0	--	--	--	--
rs138148764^1,2		--	14490095(+)	`GATTAC/TTCCCA`	3	--	us2k¹		0	--	--	--	--
rs115471402^1,2		--	14490125(+)	`TCAGTG/CATTAG`	3	--	us2k¹		1		WA	118
rs116828040^1,2	F	--	14490141(+)	`TTTTTT/ACCCCA`	3	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for CD97 (14491313 - 14519537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD97
1 CNV: 5090

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD97 for disorders           About GeneDecksing

OMIM gene information: 601211    OMIM disorders: --

20/28 diseases for CD97 (see all 28):    About MalaCards

oral squamous cell carcinoma pulmonary embolism squamous cell carcinoma pancreatic ductal adenocarcinoma

rheumatoid arthritis intrahepatic cholangiocarcinoma gaucher's disease thyroid carcinoma

thyroiditis multiple sclerosis arthritis osteoarthritis

carcinoma cholangiocarcinoma hepatitis b esophageal carcinoma

adenocarcinoma cervical cancer esophagitis cervicitis

10/16 Novoseek disease relationships for CD97 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma	54.5	9	10084602 (4), 12428789 (1), 10884186 (1)
thyroid carcinoma anaplastic	53.5	1	10084602 (1)
arthritis reactive	45.4	1	10211878 (1)
colorectal tumors	39.2	1	12414513 (1)
colorectal carcinoma	32	4	12414513 (2), 12761622 (2)
aggressiveness	25.4	2	12414513 (1), 16130195 (1)
tumors	24.5	34	20339853 (7), 12414513 (5), 12428789 (3), 12761622 (3) (see all 13)
rheumatoid arthritis	16.9	2	11037979 (1), 10211878 (1)
adenocarcinoma	14.8	7	20339853 (3), 11940212 (2), 12414513 (1), 12761622 (1)
carcinoma	11.2	7	12414513 (2), 16408199 (1), 15576472 (1), 14719104 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: CD97 (5 documents)

Export disorders for CD97 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD97 gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with CD97)

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Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. (PubMed id 7636245)^{1, 2, 3, 9} Hamann J.... van Lier R.A.W. (1995)
Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. (PubMed id 8786105)^{1, 2, 3, 9} Hamann J....van Lier R.A. (1996)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The EGF-TM7 family: a postgenomic view. (PubMed id 14647991)^{1, 2} Kwakkenbos M.J....Hamann J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. (PubMed id 12829604)^{1, 2} Stacey M.... Lin H.-H. (2003)
Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. (PubMed id 11297558)^{1, 2} Lin H.-H.... Lea S. (2001)
CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. (PubMed id 8955192)^{1, 2} Gray J.X.... Kelly K. (1996)
CD97 isoform expression in leukocytes. (PubMed id 11037979)^{1, 9} Eichler W. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 976	HGNC: 1711	AceView: CD97	Ensembl:ENSG00000123146	euGenes: HUgn976
ECgene: CD97	H-InvDB: CD97

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD97	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD97	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CD97 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD97 gene:
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GeneCards and IP:
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