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Aliases for CD96 Gene

Aliases for CD96 Gene

  • CD96 Molecule 2 3
  • CD96 Antigen 2 3 4
  • T Cell-Activated Increased Late Expression Protein 3 4
  • Cell Surface Antigen CD96 3 4
  • TACTILE 3 6
  • T Cell Activation, Increased Late Expression 3
  • T-Cell Surface Protein Tactile 3

External Ids for CD96 Gene

Previous GeneCards Identifiers for CD96 Gene

  • GC00U906250
  • GC03P112542
  • GC03P112581
  • GC03P112743
  • GC03P108635
  • GC03P111012

Summaries for CD96 Gene

Entrez Gene Summary for CD96 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD96 Gene

CD96 (CD96 Molecule) is a Protein Coding gene. Diseases associated with CD96 include c syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

UniProtKB/Swiss-Prot for CD96 Gene

  • May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD96 Gene

Genomics for CD96 Gene

Regulatory Elements for CD96 Gene

Genomic Location for CD96 Gene

Start:
111,292,719 bp from pter
End:
111,665,996 bp from pter
Size:
373,278 bases
Orientation:
Plus strand

Genomic View for CD96 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD96 Gene

Proteins for CD96 Gene

  • Protein details for CD96 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40200-TACT_HUMAN
    Recommended name:
    T-cell surface protein tactile
    Protein Accession:
    P40200
    Secondary Accessions:
    • Q5JPB3

    Protein attributes for CD96 Gene

    Size:
    585 amino acids
    Molecular mass:
    65634 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with PVR.

    Alternative splice isoforms for CD96 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD96 Gene

Proteomics data for CD96 Gene at MOPED

Post-translational modifications for CD96 Gene

  • Glycosylation at Asn42, Asn97, Asn107, Asn148, Asn156, Asn166, Asn200, Asn215, Asn277, Asn278, Asn300, Asn350, Asn368, Asn435, and Asn497
  • Modification sites at PhosphoSitePlus

Other Protein References for CD96 Gene

No data available for DME Specific Peptides for CD96 Gene

Domains for CD96 Gene

Gene Families for CD96 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD96 Gene

Suggested Antigen Peptide Sequences for CD96 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40200

UniProtKB/Swiss-Prot:

TACT_HUMAN :
  • P40200
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CD96: view

Function for CD96 Gene

Molecular function for CD96 Gene

UniProtKB/Swiss-Prot Function: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation

Gene Ontology (GO) - Molecular Function for CD96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD96: view

Phenotypes for CD96 Gene

genes like me logo Genes that share phenotypes with CD96: view

Animal Model Products

CRISPR Products

miRNA for CD96 Gene

miRTarBase miRNAs that target CD96

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD96 Gene

Localization for CD96 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD96 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD96 Gene COMPARTMENTS Subcellular localization image for CD96 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1313846
genes like me logo Genes that share ontologies with CD96: view

Pathways for CD96 Gene

genes like me logo Genes that share pathways with CD96: view

Pathways by source for CD96 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CD96 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283285%0d%0a9606.ENSP00000402060%0d%0a
Selected Interacting proteins: ENSP00000283285 P40200-TACT_HUMAN for CD96 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CD96 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1313846
GO:0007155 cell adhesion IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD96: view

Compounds for CD96 Gene

(1) Novoseek inferred chemical compound relationships for CD96 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 3.55 1
genes like me logo Genes that share compounds with CD96: view

Transcripts for CD96 Gene

Unigene Clusters for CD96 Gene

CD96 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD96

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CD96

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD96 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for CD96 Gene

GeneLoc Exon Structure for
CD96
ECgene alternative splicing isoforms for
CD96

Expression for CD96 Gene

mRNA expression in normal human tissues for CD96 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD96 Gene

This gene is overexpressed in Whole Blood (19.6), Spleen (5.2), and Small Intestine - Terminal Ileum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD96 Gene

SOURCE GeneReport for Unigene cluster for CD96 Gene Hs.142023

mRNA Expression by UniProt/SwissProt for CD96 Gene

P40200-TACT_HUMAN
Tissue specificity: Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells
genes like me logo Genes that share expressions with CD96: view

In Situ Assay Products

Orthologs for CD96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD96 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD96 35
  • 98.89 (n)
  • 97.54 (a)
CD96 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD96 35
  • 81.36 (n)
  • 68.96 (a)
CD96 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD96 35
  • 82.81 (n)
  • 74.12 (a)
CD96 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd96 35
  • 76.06 (n)
  • 61.88 (a)
Cd96 16
Cd96 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD96 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD96 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd96 35
  • 76.18 (n)
  • 61.52 (a)
lizard
(Anolis carolinensis)
Reptilia CD96 36
  • 33 (a)
OneToOne
Species with no ortholog for CD96:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD96 Gene

ENSEMBL:
Gene Tree for CD96 (if available)
TreeFam:
Gene Tree for CD96 (if available)

Paralogs for CD96 Gene

Selected SIMAP similar genes for CD96 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CD96: view

No data available for Paralogs for CD96 Gene

Variants for CD96 Gene

Sequence variations from dbSNP and Humsavar for CD96 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs721335 -- 111,570,946(+) GGTCT(C/T)GAGTG intron-variant
rs721336 -- 111,570,980(+) GTGAA(A/G)AGCTG intron-variant
rs883113 -- 111,544,557(-) TTCAT(A/T)TCTTA intron-variant
rs924262 -- 111,543,365(-) CTGAC(C/T)GAGTG intron-variant
rs968910 -- 111,547,114(-) TGTAA(C/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD96 Gene

Variant ID Type Subtype PubMed ID
nsv460821 CNV Gain 19166990
nsv3946 CNV Loss 18451855
esv269944 CNV Insertion 20981092
nsv433354 CNV Loss 18776910

Relevant External Links for CD96 Gene

HapMap Linkage Disequilibrium report
CD96
Human Gene Mutation Database (HGMD)
CD96

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD96 Gene

Disorders for CD96 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD96 Gene including...

Search for CD96 Gene in MalaCards »

(1) OMIM Diseases for CD96 Gene (606037)

UniProtKB/Swiss-Prot

TACT_HUMAN
  • C syndrome (CSYN) [MIM:211750]: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. {ECO:0000269 PubMed:17847009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.

Relevant External Links for CD96

Genetic Association Database (GAD)
CD96
Human Genome Epidemiology (HuGE) Navigator
CD96
genes like me logo Genes that share disorders with CD96: view

Publications for CD96 Gene

  1. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome. (PMID: 17847009) Kaname T. … Naritomi K. (Am. J. Hum. Genet. 2007) 3 4 23 48
  2. CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PMID: 15034010) Fuchs A. … Colonna M. (J. Immunol. 2004) 3 4 23
  3. Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily. (PMID: 1313846) Wang P.L. … Krensky A.M. (J. Immunol. 1992) 2 3 4
  4. CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. (PMID: 19056733) Meyer D. … Bernhardt G. (J. Biol. Chem. 2009) 3 23
  5. Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. (PMID: 9845376) Gramatzki M. … Moldenhauer G. (Exp. Hematol. 1998) 3 23

Products for CD96 Gene

Sources for CD96 Gene

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