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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD96 Gene

protein-coding   GIFtS: 57
GCID: GC03P111260

CD96 molecule

(Previous name: CD96 antigen )
 Explore 15 diseases affiliated with
CD96 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD96    

Aliases
for CD96 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD96 Molecule1 2     T Cell-Activated Increased Late Expression Protein2 3
CD96 Antigen1 2 3     T Cell Activation, Increased Late Expression2
TACTILE1 2 5     T-Cell Surface Protein Tactile2
Cell Surface Antigen CD962 3     

External Ids:    HGNC: 168921   Entrez Gene: 102252   Ensembl: ENSG000001532837   OMIM: 6060375   UniProtKB: P402003   

Export aliases for CD96 gene to outside databases

Previous GC identifers: GC00U906250 GC03P112542 GC03P112581 GC03P112743 GC03P108635


Summaries
for CD96 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD96:
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The
protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune
response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TACT_HUMAN, P40200
Function: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune
response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time
after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging
diseased cells and moving within areas of inflammation




Genomic Views
for CD96 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD96 gene promoter:
         SRF   CREB   SRF (504 AA)   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD96 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD96

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD96


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13-q13.2   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3p13-q13.2

CD96 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD96 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P111260:  view genomic region     (about GC identifiers)

Start:
 111,260,926 bp from pter      End:
 111,384,597 bp from pter
Size:
 123,672 bases      Orientation:
 plus strand

Proteins
for CD96 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TACT_HUMAN, P40200 (See protein sequence)
Recommended Name: T-cell surface protein tactile precursor  
Size: 585 amino acids; 65634 Da
Subunit: Homodimer; disulfide-linked. Interacts with PVR
Subcellular location: Membrane; Single-pass type I membrane protein
Developmental stage: Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation,
peaking 6 to 9 days after the activating stimulus
Secondary accessions: Q5JPB3
Alternative splicing: 2 isoforms:  P40200-1   P40200-2   

Explore the universe of human proteins at neXtProt for CD96: NX_P40200

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40200

    • CD96 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005807.1  NP_937839.1  

    ENSEMBL proteins: 
     ENSP00000342040   ENSP00000283285   ENSP00000389801   ENSP00000417680   ENSP00000417152  
     ENSP00000417150  
    Reactome Protein details: P40200
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CD96
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    Novus Biologicals CD96 Proteins
    Novus Biologicals CD96 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD96

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1313846


    CD96 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CD96

    Protein Domains /
    Families
    for CD96 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD96 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P40200

    ProtoNet protein and cluster: P40200

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: TACT_HUMAN, P40200
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Function
    for CD96 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TACT_HUMAN, P40200
    Function: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune
    response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time
    after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging
    diseased cells and moving within areas of inflammation

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD96
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CD96 (see all 12):
    hsa-miR-409-3p hsa-miR-1271 hsa-miR-3647-3p hsa-miR-664 hsa-miR-33a hsa-miR-182 hsa-miR-29a* hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmid: CD96 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD96 (see all 7)
    OriGene shRNA RFP: CD96
    OriGene siRNA: CD96
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD96

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD96

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD96 (see all 4)
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    Sino Biological Human cDNA Clone for CD96
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD96 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD96

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD96

    2 GenomeRNAi human phenotypes for CD96:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 


    Pathways & Interactions
    for CD96 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for CD96
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System



    CD96 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD96

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD96 (P402003 ENSP000002832854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PVRP151513, ENSP000004020604I2D: score=1 STRING: ENSP00000402060
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS1313846
    GO:0007155cell adhesion IEA--
    GO:0050776regulation of immune response TAS--


    CD96 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD96 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD96 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD96
    1 Novoseek chemical compound relationship for CD96 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 3.55 1 1701034 (1)

    Search CenterWatch for drugs/clinical trials and news about CD96 / TACT 

    Transcripts
    for CD96 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD96 gene (2 alternative transcripts): 
    NM_005816.4  NM_198196.2  

    Unigene Cluster for CD96:

    CD96 molecule
    Hs.142023  [show with all ESTs]
    Unigene Representative Sequence: NM_198196
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352690(uc003dxx.3) ENST00000283285(uc003dxw.3) ENST00000438817(uc003dxv.3)
    ENST00000488054 ENST00000494798(uc010hpy.1) ENST00000465428

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD96
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate CD96 (see all 12):
    hsa-miR-409-3p hsa-miR-1271 hsa-miR-3647-3p hsa-miR-664 hsa-miR-33a hsa-miR-182 hsa-miR-29a* hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmid: CD96 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD96 (see all 7)
    OriGene shRNA RFP: CD96
    OriGene siRNA: CD96
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD96
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD96 (NM_005816)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD96
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD96 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD96
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD96
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD96

    Additional cDNA sequence: 

    AK290719.1 AK315237.1 AL833681.1 BC020749.1 

    7 DOTS entries:

    DT.95305568  DT.100751999  DT.100751998  DT.86859118  DT.92418273  DT.92418274  DT.95086934 

    24/47 AceView cDNA sequences (see all 47):

    AW512609 NM_198196 BX415809 AA478280 AL833681 CD245004 NM_005816 BU188513 
    BM917289 AW770162 BE502619 CD703884 BC020749 BM561433 BM998935 AW292416 
    CF137690 AI652836 AW770161 CD695421 BC027914 CD691315 BI767649 AI287440 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD96    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -                                       
    SP2:                                                                  


    ECgene alternative splicing isoforms for CD96

    Expression
    for CD96 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD96 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTACAGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD96 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    White adipocyte-like cells (Differentiation of ...)Adipose

    See CD96 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD96

    SOURCE GeneReport for Unigene cluster: Hs.142023

    UniProtKB/Swiss-Prot: TACT_HUMAN, P40200
    Tissue specificity: Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured
    cell lines tested. It is expressed at very low levels on activated B-cells

        SABiosciences Expression via Pathway-Focused PCR Array including CD96: 
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CD96 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD96 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd961 , 5 CD96 antigen1, 5 76.06(n)1
    61.88(a)1    		   16 (30.45 cM)5
    845441  NM_032465.21  NP_115854.21 
     460356575 


    ENSEMBL Gene Tree for CD96 (if available)
    TreeFam Gene Tree for CD96 (if available) 

    Paralogs
    for CD96 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CD96 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1768 NCBI SNPs in CD96 are shown (see all 1768)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs783651261,2
    		F,--108633967(+) TAGAAG/ATTTCT 2 -- us2k11Minor allele frequency- A:0.14WA 118
    rs800166851,2
    		F,--108634209(+) ACCCCA/CAAGAG 2 -- us2k11Minor allele frequency- C:0.17WA 118
    rs1125822611,2
    		F--108634260(+) TGGTTC/TCTACT 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs747522301,2
    		F,--108634971(+) CTGGCC/ATTTTC 2 -- us2k11Minor allele frequency- A:0.08WA 118
    rs13913571,2
    		C,F,--108635055(-) CAACCG/ATATGA 2 -- us2k1 tfbs31Minor allele frequency- A:0.24WA 118
    rs794415051,2
    		F,--108635229(+) GTCATC/TGTGTT 2 -- us2k11Minor allele frequency- T:0.13WA 118
    rs746414571,2
    		F,--108635640(+) TTAATT/GCTTTG 2 -- us2k11Minor allele frequency- G:0.13WA 118
    rs790142401,2
    		--108635746(+) ACTTTG/TTGCTC 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs803054301,2
    		F,--108636572(+) TTACAA/GAGCCA 2 -- int11Minor allele frequency- G:0.13WA 118
    rs752511231,2
    		C,F,--108637266(+) TCACTC/TAGTCA 2 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for CD96 (111260926 - 111384597 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD96: --
    Human Gene Mutation Database (HGMD): CD96

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD96
    DNA2.0 Custom Variant and Variant Library Synthesis for CD96

    Disorders / Diseases
    for CD96 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD96 for disorders           About GeneDecksing

    OMIM gene information: 606037   
    OMIM disorders: 211750  605039  
    UniProtKB/Swiss-Prot: TACT_HUMAN, P40200
  • Defects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This
    • syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges,
    multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia.
    Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation
    t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the
    breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature
    termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint

    15 diseases for CD96:    About MalaCards
    c-like syndrome    type 1 diabetes mellitus    diabetes mellitus    acute lymphoblastic leukemia
    lymphoblastic leukemia    acute myeloid leukemia    myeloid leukemia    rheumatoid arthritis
    hypotonia    leukemia    hepatitis b    copd
    acute leukemia    arthritis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CD96:
    Acute myeloid leukemia
    Human Genome Epidemiology (HuGE) Navigator: CD96 (3 documents)

    Export disorders for CD96 gene to outside databases

    Publications
    for CD96 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD96 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CD96)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily. (PubMed id 1313846)1, 2, 3 Wang P.L.... Krensky A.M. (1992)
    2. CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PubMed id 15034010)1, 2, 9 Fuchs A.... Colonna M. (2004)
    3. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome. (PubMed id 17847009)1, 2, 9 Kaname T....Naritomi K. (2007)
    4. CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. (PubMed id 19056733)1, 9 Meyer D....Bernhardt G. (2009)
    5. Antibodies TC-12 ('unique') and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. (PubMed id 9845376)1, 9 Gramatzki M....Moldenhauer G. (1998)
    6. Enhanced ADCC activity of affinity maturated and Fc-en gineered mini-antibodies directed against the AML stem cell antigen CD96. (PubMed id 22879978)1 Mohseni Nodehi S....Humpe A. (2012)
    7. [CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia]. (PubMed id 21729528)1 Wu Y....Deng J.N. (2011)
    8. Genome-wide association study of smoking behaviours i n patients with COPD. (PubMed id 21685187)1 Siedlinski M....Silverman E.K. (2011)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    10. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)

    External Searches for CD96 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CD96 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10225 HGNC: 16892 AceView: CD96 Ensembl:ENSG00000153283 euGenes: HUgn10225
    ECgene: CD96 H-InvDB: CD96

    Other Databases showing CD96 gene

    (According to HUGE)
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    Specialized Databases showing CD96 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD96 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD96 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for CD96 gene:
    Search GeneIP for patents involving CD96

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