Aliases for CD93 Gene
External Ids for CD93 Gene
Previous Symbols for CD93 Gene
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD93 Gene
CD93 (CD93 Molecule) is a Protein Coding gene. Diseases associated with CD93 include splenic abscess and c1 inhibitor deficiency. Among its related pathways are Complement Pathway and Complement Pathway. GO annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is CLEC14A.
UniProtKB/Swiss-Prot for CD93 Gene
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion