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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD93 Gene

protein-coding   GIFtS: 55
GCID: GC20M023059

CD93 molecule

(Previous names: matrix-remodelling associated 4, complement component 1,...)
(Previous symbols: MXRA4, C1QR1)
 Explore 19 diseases affiliated with
CD93 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD93    

Aliases
for CD93 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD93 Molecule1 2     Matrix-Remodelling Associated 41 2
C1QR11 2 3     Complement Component 1 Q Subcomponent Receptor 12 3
CDw931 2 3     Matrix-Remodeling-Associated Protein 42 3
MXRA41 2 3     C1qR2 3
CD93 Antigen1 2 3     C1q/MBL/SPA Receptor2 3
C1qR(P)1 2     C1q Receptor 12
C1qRP1 2     Complement Component C1q Receptor2
ECSM31 2     C1qR(P)1 2
Complement Component 1, Q Subcomponent, Receptor 11 2     C1qRp3
DJ737E23.11     

External Ids:    HGNC: 158551   Entrez Gene: 229182   Ensembl: ENSG000001258107   OMIM: 1205775   UniProtKB: Q9NPY33   

Export aliases for CD93 gene to outside databases

Previous GC identifer: GC20M023008


Summaries
for CD93 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD93:
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally
identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now
is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular
cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking
transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary
surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction
with soluble defense collagens. May play a role in intercellular adhesion

Gene Wiki entry for CD93


Genomic Views
for CD93 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD93 gene promoter:
         FOXF2   RelA   NF-kappaB   Evi-1   GATA-1   AREB6   CP2   Zic1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD93 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD93

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD93


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.21

CD93 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD93 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023059:  view genomic region     (about GC identifiers)

Start:
 23,059,986 bp from pter      End:
 23,066,977 bp from pter
Size:
 6,992 bases      Orientation:
 minus strand

Proteins
for CD93 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3 (See protein sequence)
Recommended Name: Complement component C1q receptor precursor  
Size: 652 amino acids; 68560 Da
Subunit: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q
receptor
Subcellular location: Membrane; Single-pass type I membrane protein
Caution: Has been sometimes referred to as a collectin receptor
Caution: PubMed:11994479 reported that C1q is not a ligand for C1QR1
Secondary accessions: O00274

Explore the universe of human proteins at neXtProt for CD93: NX_Q9NPY3

Post-translational modifications:

  • N- and O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPY3

    • CD93 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036204.2  
    ENSEMBL proteins: 
     ENSP00000246006  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD93 (C1q R1/CD93)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CD93
    OriGene Protein Over-expression Lysate: CD93
    OriGene Custom Protein Services for CD93 
    GenScript Custom Purified and Recombinant Proteins Services for CD93
    Novus Biologicals CD93 Proteins
    Novus Biologicals CD93 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane IC9047234
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--


    CD93 for ontologies           About GeneDecksing



    CD93 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD93
    R&D Systems Antibodies for CD93 (C1q R1/CD93)
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    Abcam antibodies for CD93 
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    ThermoFisher Antibodies for CD93

    Assay Products for CD93: 
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    OriGene Custom Immunoassay Development
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    R&D Systems ELISAs for CD93 (C1q R1/CD93)         (see all)
    GenScript Custom Assay Services for CD93
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CD93 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD93 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR016316 CD93/CD141

    Graphical View of Domain Structure for InterPro Entry Q9NPY3

    ProtoNet protein and cluster: Q9NPY3

    2 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 5 EGF-like domains


    Function
    for CD93 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
    Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary
    surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction
    with soluble defense collagens. May play a role in intercellular adhesion

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CD93
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD93
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CD93 (see all 28):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-4307 hsa-miR-4328 hsa-miR-3653 hsa-miR-3133 hsa-miR-507 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD93 (see all 7)
    OriGene shRNA RFP: CD93
    OriGene siRNA: CD93
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD93

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD93

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD93 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD93
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CD93 (NM_012072)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD93
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD93 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD93
    Search LifeMap BioReagents cell lines for CD93

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD93

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001849complement component C1q binding IDA11781389
    GO:0004872receptor activity NAS9047234
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15459234
    GO:0030246carbohydrate binding IEA--


    CD93 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CD93:
     Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Cd93tm1Mbo for CD93
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cd93):
     immune system 

    CD93 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD93 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_Classical complement pathway
    		Immune response_Classical complement pathway1.00
    		Immune response Classic complement pathway0.98
    2Immune response_Alternative complement pathway
    		Immune response Lectin Induced complement pathway0.56
    		Immune response_Lectin induced complement pathway0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CD93
        Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway


    2 GeneGo (Thomson Reuters) Pathways for CD93
        Immune response Classical complement pathway
    Immune response Lectin induced complement pathway



    CD93 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD93

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for CD93 (Q9NPY33 ENSP000002460064) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    COL1A1P024523, ENSP000002259644I2D: score=1 STRING: ENSP00000225964
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    KNG1P010423, ENSP000002650234I2D: score=2 STRING: ENSP00000265023
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis NAS11781389
    GO:0016337cell-cell adhesion IDA11994479
    GO:0019048virus-host interaction IEA--
    GO:0042116macrophage activation NAS9047234
    GO:0044419interspecies interaction between organisms ----


    CD93 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD93 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD93 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD93
    2 Novoseek chemical compound relationships for CD93 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 18.5 2 16673132 (2)
    superoxide 10.1 2 7911495 (1)

    Search CenterWatch for drugs/clinical trials and news about CD93 / C1QR1 

    Transcripts
    for CD93 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD93 gene: 
    NM_012072.3  

    Unigene Cluster for CD93:

    CD93 molecule
    Hs.97199  [show with all ESTs]
    Unigene Representative Sequence: NM_012072
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246006(uc002wsv.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD93
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CD93 (see all 28):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-4307 hsa-miR-4328 hsa-miR-3653 hsa-miR-3133 hsa-miR-507 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD93 (see all 7)
    OriGene shRNA RFP: CD93
    OriGene siRNA: CD93
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD93
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD93 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD93
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CD93 (NM_012072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD93
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD93 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD93
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD93
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD93
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD93

    Additional cDNA sequence: 

    AB209895.1 AF391800.1 AJ295142.1 AK056764.1 AK299957.1 BC028075.1 U94333.1 

    4 DOTS entries:

    DT.314686  DT.120812116  DT.100814619  DT.120812121 

    24/185 AceView cDNA sequences (see all 185):

    AA634851 AK056764 BP343937 AW070540 BQ889094 BM988034 CR611513 AA707552 
    BQ884088 AW305344 AW150037 AW511241 CD677473 BM833744 BX505791 AW167390 
    BQ630932 T09113 BX474641 AA487558 AA029719 BF732946 AI565274 AI339727 

    GeneLoc Exon Structure


    Expression
    for CD93 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD93 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCCAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD93 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneBone MarrowHematopoietic Stem CellsBlood
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    HeartHeart TubeHeart
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    CD31, CD144 positive cells (Two-step protocol fo...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Beating cell clusters (Spontaneous differen...)

    See CD93 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD93

    SOURCE GeneReport for Unigene cluster: Hs.97199

    UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
    Tissue specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and
    neutrophils. Not expressed in cells of lymphoid origin

        SABiosciences Custom PCR Arrays for CD93
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD93
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD93

    Orthologs
    for CD93 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CD93 gene from 2/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CD931 CD93 molecule 58(n)
    46.31(a)    		   421234  NM_001199451.1  NP_001186380.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fbn-16
    		 FiBrilliN homolog family member (fbn-1)
    		 5(a)
    		 1 → many
    		 III(7625311-7640988)


    ENSEMBL Gene Tree for CD93 (if available)
    TreeFam Gene Tree for CD93 (if available) 

    Paralogs
    for CD93 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD93 gene
    CLEC14A2  THBD2  CD2482  

    CD93 for paralogs           About GeneDecksing



    Genomic Variants
    for CD93 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/253 NCBI SNPs in CD93 are shown (see all 253)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1492870851,2
    		--23059608(+) ACATCA/GCATCC 1 -- ds50010--------
    rs1867200751,2
    		--23059635(+) TCTGCA/GCCAGG 1 -- ds50010--------
    rs1173119411,2
    		--23059782(+) CTGAGG/AGGCAG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1900800641,2
    		--23059830(+) CCAGCG/TCCCCC 1 -- ds50010--------
    rs1817329291,2
    		--23059859(+) CAGGTA/GCAGAA 1 -- ds50010--------
    rs1435724111,2
    		--23059877(+) CACAAA/GGTACC 1 -- ds50010--------
    rs1855907521,2
    		--23059966(+) TTGTCA/GTGAAA 1 -- ds50010--------
    rs1903048331,2
    		--23060116(+) AGCTCA/GATCTC 1 -- ut310--------
    rs1808012501,2
    		--23060135(+) CCCTCC/TTCACA 1 -- ut310--------
    rs414925451,2
    		C,F,--23060148(-) ATGTTT/GCCCAA 1 -- ut312Minor allele frequency- G:0.08NA WA 166

    HapMap Linkage Disequilibrium report for CD93 (23059986 - 23066977 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CD93
         1 CNV: 4097

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    Disorders / Diseases
    for CD93 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD93 for disorders           About GeneDecksing

    OMIM gene information: 120577    OMIM disorders: --

    19 diseases for CD93:    About MalaCards
    splenic abscess    non-hodgkin lymphoma    hemorrhagic fever    hemorrhagic fever with renal syndrome
    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma    coronary heart disease
    familial hypercholesterolemia    hypercholesterolemia    angioedema    hepatitis c
    hepatitis b    alzheimer's disease    meningioma    hepatitis
    breast cancer    hypoxia    leukemia

    1 disease from the University of Copenhagen DISEASES database for CD93:
    Splenic abscess

    1 Novoseek disease relationship for CD93 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 11428648 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD93 (10 documents)

    Export disorders for CD93 gene to outside databases

    Publications
    for CD93 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD93 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with CD93)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. (PubMed id 9047234)1, 2, 3, 9 Nepomuceno R.R.... Tenner A.J. (1997)
    2. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (PubMed id 10092817)1, 2, 9 Nepomuceno R.R.... Tenner A.J. (1999)
    3. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. (PubMed id 11781389)1, 2, 9 Steinberger P.... Knapp W. (2002)
    4. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. (PubMed id 11994479)1, 2, 9 McGreal E.P.... Gasque P. (2002)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. (PubMed id 10648005)1, 3 Webster S.D....Tenner A.J. (2000)
    8. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. (PubMed id 11086025)1, 2 Kittlesen D.J....Hahn Y.S. (2000)
    9. Modulated interaction of the ERM protein, moesin, with CD93. (PubMed id 15819698)1, 9 Zhang M....Tenner A.J. (2005)
    10. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. (PubMed id 18094537)1, 9 Ikewaki N....Inoko H. (2007)

    External Searches for CD93 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CD93 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22918 HGNC: 15855 AceView: C1QR1 Ensembl:ENSG00000125810 euGenes: HUgn22918
    ECgene: CD93 H-InvDB: CD93

    Other Databases showing CD93 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD93 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD93 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD93 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD93 gene:
    Search GeneIP for patents involving CD93

    GeneCards and IP:
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