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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD93 Gene

protein-coding   GIFtS: 57
GCID: GC20M023059

CD93 Molecule

(Previous names: matrix-remodelling associated 4, complement component 1,...)
(Previous symbols: MXRA4, C1QR1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD93 Molecule1 2     C1q/MBL/SPA Receptor2 3
C1QR11 2 3     C1qR(P)2
MXRA41 2 3     C1qRP2
CD93 Antigen1 2 3     ECSM32
Complement Component 1, Q Subcomponent, Receptor 11 2     C1q Receptor 12
Matrix-Remodelling Associated 41 2     Complement Component C1q Receptor2
Complement Component 1 Q Subcomponent Receptor 12 3     dJ737E23.12
Matrix-Remodeling-Associated Protein 42 3     C1qR(p)3
C1qR2 3     C1qRp3
CDw932 3     

External Ids:    HGNC: 158551   Entrez Gene: 229182   Ensembl: ENSG000001258107   OMIM: 1205775   UniProtKB: Q9NPY33   

Export aliases for CD93 gene to outside databases

Previous GC identifer: GC20M023008


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD93 Gene:
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally
identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but
now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The
intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a
role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CD93 Gene: 
CD93 (CD93 molecule) is a protein-coding gene. Diseases associated with CD93 include splenic abscess, and c1 inhibitor deficiency, and among its related super-pathways are Immune response Lectin induced complement pathway. GO annotations related to this gene include carbohydrate binding and calcium ion binding. An important paralog of this gene is CLEC14A.

UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary
surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon
interaction with soluble defense collagens. May play a role in intercellular adhesion

Gene Wiki entry for CD93 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD93 gene promoter:
         FOXF2   RelA   NF-kappaB   Evi-1   GATA-1   AREB6   CP2   Zic1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD93 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD93

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD93


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.21

CD93 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD93 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023059:  view genomic region     (about GC identifiers)

Start:
23,059,986 bp from pter      End:
23,066,977 bp from pter
Size:
6,992 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3 (See protein sequence)
Recommended Name: Complement component C1q receptor precursor  
Size: 652 amino acids; 68560 Da
Subunit: Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q
receptor
Subcellular location: Membrane; Single-pass type I membrane protein
Caution: Has been sometimes referred to as a collectin receptor
Caution: PubMed:11994479 reported that C1q is not a ligand for C1QR1
Secondary accessions: O00274

Explore the universe of human proteins at neXtProt for CD93: NX_Q9NPY3

Explore proteomics data for CD93 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPY3

  • CD93 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD93 Protein Expression
    REFSEQ proteins: NP_036204.2  
    ENSEMBL proteins: 
     ENSP00000246006  

    Human Recombinant Protein Products for CD93: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD93
    OriGene Protein Over-expression Lysate for CD93
    OriGene MassSpec for CD93 
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    GenScript Custom Purified and Recombinant Proteins Services for CD93
    Novus Biologicals CD93 Proteins
    Novus Biologicals CD93 Lysate
    Sino Biological Recombinant Protein for CD93
    Sino Biological Cell Lysate for CD93 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane IC9047234
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    CD93 for ontologies           About GeneDecksing



    CD93 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD93
    R&D Systems Antibodies for CD93 (C1q R1/CD93)
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    GenScript Custom Superior Antibodies Services for CD93
    Novus Biologicals CD93 Antibodies
    Abcam antibodies for CD93
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD93
    LSBio Antibodies in human, mouse, rat for CD93 

    Assay Products for CD93: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CD93 (C1q R1/CD93)         (see all)
    GenScript Custom Assay Services for CD93
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    5/10 InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR016316 CD93/CD141

    Graphical View of Domain Structure for InterPro Entry Q9NPY3

    ProtoNet protein and cluster: Q9NPY3

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 5 EGF-like domains


    CD93 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C1QR1_HUMAN, Q9NPY3
    Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary
    surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon
    interaction with soluble defense collagens. May play a role in intercellular adhesion

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001849complement component C1q binding IDA11781389
    GO:0004872receptor activity NAS9047234
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15459234
    GO:0030246carbohydrate binding IEA--
         
    CD93 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD93:
     Synthetic lethal with imatinib 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cd93):
     immune system 

    CD93 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd93tm1Mbo for CD93

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD93 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD93

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD93 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD93 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD93
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CD93 (see all 28):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-4307 hsa-miR-4328 hsa-miR-3653 hsa-miR-3133 hsa-miR-507 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD93
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD93

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD93
    Sirion Biotech Customized adenovirus for overexpression of CD93

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD93 (see all 7)
    OriGene ORF clones in mouse, rat for CD93
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD93 (NM_012072)
    Sino Biological Human cDNA Clone for CD93
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD93
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD93
    Sirion Biotech Customized lentivirus for stable overexpression of CD93 
                         Customized lentivirus expression plasmids for stable overexpression of CD93 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD93
    Search LifeMap BioReagents cell lines for CD93
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD93


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD93 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classic complement pathway0.53
    Immune response Lectin Induced complement pathway0.56
    Immune response Classical complement pathway0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CD93
        Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway


    2 GeneGo (Thomson Reuters) Pathways for CD93
        Immune response Classical complement pathway
    Immune response Lectin induced complement pathway




    CD93 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD93

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CD93 (Q9NPY33 ENSP000002460064) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    COL1A1P024523, ENSP000002259644I2D: score=1 STRING: ENSP00000225964
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    KNG1P010423, ENSP000002650234I2D: score=2 STRING: ENSP00000265023
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis NAS10092817
    GO:0016337cell-cell adhesion IDA11994479
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0042116macrophage activation NAS9047234

    CD93 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD93 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD93 (C1QR1)

    2 Novoseek inferred chemical compound relationships for CD93 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 18.5 2 16673132 (2)
    superoxide 10.1 2 7911495 (1)

    Search CenterWatch for drugs/clinical trials and news about CD93 / C1QR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD93 gene: 
    NM_012072.3  

    Unigene Cluster for CD93:

    CD93 molecule
    Hs.97199  [show with all ESTs]
    Unigene Representative Sequence: NM_012072
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246006(uc002wsv.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD93
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CD93 (see all 28):
    hsa-miR-3678-3p hsa-miR-3685 hsa-miR-4307 hsa-miR-4328 hsa-miR-3653 hsa-miR-3133 hsa-miR-507 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD93
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD93
    Clone
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    OriGene clones in human, mouse for CD93 (see all 7)
    OriGene ORF clones in mouse, rat for CD93
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    GenScript: all cDNA clones in your preferred vector: CD93 (NM_012072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD93
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD93
    Sirion Biotech Customized lentivirus for stable overexpression of CD93 
                         Customized lentivirus expression plasmids for stable overexpression of CD93 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD93
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD93
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD93

    Additional mRNA sequence: 

    AB209895.1 AF391800.1 AJ295142.1 AK056764.1 AK299957.1 BC028075.1 U94333.1 

    4 DOTS entries:

    DT.314686  DT.120812116  DT.100814619  DT.120812121 

    24/185 AceView cDNA sequences (see all 185):

    BQ630932 BM988034 BM833744 AA044236 BQ884088 CR611513 AK056764 AW070540 
    T09113 AI937452 AA788793 AW511241 AI378169 AA487558 AW167390 BX474641 
    BF732946 BQ787747 BQ889094 AW305344 AI093977 AA707552 AI339727 AA634851 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD93 expression in normal human tissues (normalized intensities)      CD93 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCCAAAC
    CD93 Expression
    About this image


    CD93 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 26 entries
             PureStem endothelial progenitor 30-SM2-1
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Pro B-Cells Hematopoietic Bone Marrow
             PureStem endothelial Progenitor 30-SM2-3
             Bone Marrow CD33+ Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   

    See CD93 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD93

    SOURCE GeneReport for Unigene cluster: Hs.97199

    UniProtKB/Swiss-Prot: C1QR1_HUMAN, Q9NPY3
    Tissue specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes
    and neutrophils. Not expressed in cells of lymphoid origin

        SABiosciences Custom PCR Arrays for CD93
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD93
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD93

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD93 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd931 , 5 CD93 antigen1, 5 73.5(n)1
    68.94(a)1
      2 (73.48 cM)5
    170641  NM_010740.31  NP_034870.11 
     1484366405 
    chicken
    (Gallus gallus)
    Aves CD931 CD93 molecule 58(n)
    46.31(a)
      421234  NM_001199451.1  NP_001186380.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD936
    Uncharacterized protein
    30(a)
    1 ↔ 1
    4(82158614-82160362)
    zebrafish
    (Danio rerio)
    Actinopterygii CD936
    CD93 molecule
    24(a)
    1 ↔ 1
    17(45726703-45728361)


    ENSEMBL Gene Tree for CD93 (if available)
    TreeFam Gene Tree for CD93 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD93 gene
    CLEC14A2  THBD2  CD2482  

    CD93 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in CD93 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364004
    A colorectal cancer sample4--see VAR_0364002 A V mis40--------
    VAR_0135734
    ----see VAR_0135732 V A mis40--------
    rs1492870851,2
    --23059608(+) ACATCA/GCATCC 1 -- ds50010--------
    rs1867200751,2
    --23059635(+) TCTGCA/GCCAGG 1 -- ds50010--------
    rs1173119411,2
    F--23059782(+) CTGAGG/AGGCAG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1900800641,2
    --23059830(+) CCAGCG/TCCCCC 1 -- ds50010--------
    rs1817329291,2
    --23059859(+) CAGGTA/GCAGAA 1 -- ds50010--------
    rs1435724111,2
    --23059877(+) CACAAA/GGTACC 1 -- ds50010--------
    rs1855907521,2
    --23059966(+) TTGTCA/GTGAAA 1 -- ds50010--------
    rs1903048331,2
    --23060116(+) AGCTCA/GATCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD93 (23059986 - 23066977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD93:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526474CNV Loss19592680
    nsv912816CNV Gain21882294
    dgv1317e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120577    OMIM disorders: --

    20/21 diseases for CD93 (see all 21):    About MalaCards
    splenic abscess    c1 inhibitor deficiency    hemorrhagic fever with renal syndrome    familial hypercholesterolemia
    hemorrhagic fever    angioedema    hypercholesterolemia    coronary heart disease
    non-hodgkin lymphoma    hodgkin's lymphoma    meningioma    hypoxia
    systemic lupus erythematosus    hepatitis c    endotheliitis    lupus erythematosus
    hepatitis b    hepatitis    alzheimer's disease    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CD93:
    Splenic abscess

    CD93 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for CD93 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 11428648 (1)

    Genetic Association Database (GAD): CD93
    Human Genome Epidemiology (HuGE) Navigator: CD93 (10 documents)

    Export disorders for CD93 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD93 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with CD93)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. (PubMed id 9047234)1, 2, 3, 9 Nepomuceno R.R.... Tenner A.J. (1997)
    2. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (PubMed id 10092817)1, 2, 9 Nepomuceno R.R.... Tenner A.J. (1999)
    3. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. (PubMed id 11781389)1, 2, 9 Steinberger P.... Knapp W. (2002)
    4. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. (PubMed id 11994479)1, 2, 9 McGreal E.P.... Gasque P. (2002)
    5. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PubMed id 18599554)1, 4, 9 van der Net J.B....Sijbrands E.J. (2008)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
    9. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (PubMed id 19166692)1, 4 van der Net J.B....Steyerberg E.W. (2009)
    10. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4 Lee J.Y....Kang D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22918 HGNC: 15855 AceView: C1QR1 Ensembl:ENSG00000125810 euGenes: HUgn22918
    ECgene: CD93 H-InvDB: CD93

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD93 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD93 gene:
    Search GeneIP for patents involving CD93

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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