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Aliases for CD93 Gene

Aliases for CD93 Gene

  • CD93 Molecule 2 3
  • CD93 Antigen 2 3 4
  • C1QR1 3 4 6
  • C1qR 3 4 6
  • Complement Component 1, Q Subcomponent, Receptor 1 2 3
  • Complement Component 1 Q Subcomponent Receptor 1 3 4
  • Matrix-Remodeling-Associated Protein 4 3 4
  • Matrix-Remodelling Associated 4 2 3
  • C1q/MBL/SPA Receptor 3 4
  • C1qR(P) 3 4
  • C1qRP 3 4
  • MXRA4 3 4
  • CDw93 3 4
  • Complement Component C1q Receptor 3
  • C1q Receptor 1 3
  • DJ737E23.1 3
  • ECSM3 3

External Ids for CD93 Gene

Previous HGNC Symbols for CD93 Gene

  • MXRA4
  • C1QR1

Previous GeneCards Identifiers for CD93 Gene

  • GC20M023008
  • GC20M023059

Summaries for CD93 Gene

Entrez Gene Summary for CD93 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD93 Gene

CD93 (CD93 Molecule) is a Protein Coding gene. Diseases associated with CD93 include splenic abscess and c1 inhibitor deficiency. Among its related pathways are Complement Pathway and Complement Pathway. GO annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is CLEC14A.

UniProtKB/Swiss-Prot for CD93 Gene

  • Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion

Gene Wiki entry for CD93 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD93 Gene

Genomics for CD93 Gene

Regulatory Elements for CD93 Gene

Genomic Location for CD93 Gene

23,079,349 bp from pter
23,086,340 bp from pter
6,992 bases
Minus strand

Genomic View for CD93 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD93 Gene

Proteins for CD93 Gene

  • Protein details for CD93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component C1q receptor
    Protein Accession:
    Secondary Accessions:
    • O00274

    Protein attributes for CD93 Gene

    652 amino acids
    Molecular mass:
    68560 Da
    Quaternary structure:
    • Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.

neXtProt entry for CD93 Gene

Proteomics data for CD93 Gene at MOPED

Post-translational modifications for CD93 Gene

Other Protein References for CD93 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD93 Gene

Domains for CD93 Gene

Gene Families for CD93 Gene

  • CD :CD molecules

Suggested Antigen Peptide Sequences for CD93 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NPY3
  • Contains 1 C-type lectin domain.
  • Contains 5 EGF-like domains.
genes like me logo Genes that share domains with CD93: view

Function for CD93 Gene

Molecular function for CD93 Gene

UniProtKB/Swiss-Prot Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion

Gene Ontology (GO) - Molecular Function for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 11781389
GO:0004872 receptor activity NAS 9047234
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15459234
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD93: view

Phenotypes for CD93 Gene

genes like me logo Genes that share phenotypes with CD93: view

Animal Models for CD93 Gene

MGI Knock Outs for CD93:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD93 Gene

Localization for CD93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD93 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD93 Gene COMPARTMENTS Subcellular localization image for CD93 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IC 9047234
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with CD93: view

Pathways for CD93 Gene

genes like me logo Genes that share pathways with CD93: view

Pathways by source for CD93 Gene

Gene Ontology (GO) - Biological Process for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006909 phagocytosis NAS 10092817
GO:0016032 viral process IEA --
GO:0016337 single organismal cell-cell adhesion IDA 11994479
GO:0042116 macrophage activation NAS 9047234
genes like me logo Genes that share ontologies with CD93: view

Compounds for CD93 Gene

(2) Novoseek inferred chemical compound relationships for CD93 Gene

Compound -log(P) Hits PubMed IDs
dexamethasone 18.5 2
superoxide 10.1 1
genes like me logo Genes that share compounds with CD93: view

Transcripts for CD93 Gene

mRNA/cDNA for CD93 Gene

(185) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD93 Gene

CD93 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD93 Gene

No ASD Table

Relevant External Links for CD93 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD93 Gene

mRNA expression in normal human tissues for CD93 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD93 Gene

This gene is overexpressed in Whole Blood (5.5) and Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD93 Gene

SOURCE GeneReport for Unigene cluster for CD93 Gene Hs.97199

mRNA Expression by UniProt/SwissProt for CD93 Gene

Tissue specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin
genes like me logo Genes that share expressions with CD93: view

Orthologs for CD93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD93 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD93 35
  • 98.77 (n)
  • 97.85 (a)
CD93 36
  • 98 (a)
(Bos Taurus)
Mammalia CD93 35
  • 77.33 (n)
  • 71.41 (a)
CD93 36
  • 67 (a)
(Canis familiaris)
Mammalia CD93 35
  • 77.83 (n)
  • 71.82 (a)
CD93 36
  • 69 (a)
(Mus musculus)
Mammalia Cd93 35
  • 73.45 (n)
  • 69 (a)
Cd93 16
Cd93 36
  • 68 (a)
(Monodelphis domestica)
Mammalia CD93 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CD93 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Cd93 35
  • 72.51 (n)
  • 67.68 (a)
(Gallus gallus)
Aves CD93 35
  • 54.38 (n)
  • 41.78 (a)
CD93 36
  • 40 (a)
(Anolis carolinensis)
Reptilia CD93 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd93 35
  • 52.45 (n)
  • 43.19 (a)
(Danio rerio)
Actinopterygii CD93 36
  • 31 (a)
LOC101882826 35
  • 45.33 (n)
  • 35.2 (a)
Species with no ortholog for CD93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD93 Gene

Gene Tree for CD93 (if available)
Gene Tree for CD93 (if available)

Paralogs for CD93 Gene

Paralogs for CD93 Gene

genes like me logo Genes that share paralogs with CD93: view

Variants for CD93 Gene

Sequence variations from dbSNP and Humsavar for CD93 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7492 -- 23,079,620(+) TTAGC(A/G)TTCAT utr-variant-3-prime
rs1044051 -- 23,079,467(-) CTCCT(C/T)TGAGT utr-variant-3-prime
rs2567612 -- 23,082,535(+) TGTCT(C/G)TGTGT utr-variant-3-prime
rs2567616 -- 23,087,512(+) TTCTA(G/T)CCctg upstream-variant-2KB
rs2749811 -- 23,079,544(+) GCATA(A/G)AAATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD93 Gene

Variant ID Type Subtype PubMed ID
nsv912816 CNV Gain 21882294
dgv1317e1 CNV Complex 17122850
nsv526474 CNV Loss 19592680

Relevant External Links for CD93 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD93 Gene

Disorders for CD93 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CD93 Gene including...

Search for CD93 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CD93 Gene

(1) Novoseek inferred disease relationships for CD93 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 1

Relevant External Links for CD93

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD93: view

No data available for UniProtKB/Swiss-Prot for CD93 Gene

Publications for CD93 Gene

  1. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. (PMID: 9047234) Nepomuceno R.R. … Tenner A.J. (Immunity 1997) 2 3 4 23
  2. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (PMID: 10092817) Nepomuceno R.R. … Tenner A.J. (J. Immunol. 1999) 3 4 23
  3. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. (PMID: 11781389) Steinberger P. … Knapp W. (J. Leukoc. Biol. 2002) 3 4 23
  4. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. (PMID: 11994479) McGreal E.P. … Gasque P. (J. Immunol. 2002) 3 4 23
  5. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net J.B. … Sijbrands E.J. (Eur. Heart J. 2008) 3 23 48

Products for CD93 Gene

Sources for CD93 Gene

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