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Aliases for CD93 Gene

Aliases for CD93 Gene

  • CD93 Molecule 2 3 5
  • CD93 Antigen 2 3 4
  • Complement Component 1 Q Subcomponent Receptor 1 3 4
  • Matrix-Remodeling-Associated Protein 4 3 4
  • Matrix-Remodelling Associated 4 2 3
  • C1q/MBL/SPA Receptor 3 4
  • C1qR(P) 3 4
  • C1qRP 3 4
  • C1QR1 3 4
  • MXRA4 3 4
  • CDw93 3 4
  • C1qR 3 4
  • Complement Component 1, Q Subcomponent, Receptor 1 2
  • Complement Component C1q Receptor 3
  • C1q Receptor 1 3
  • DJ737E23.1 3
  • ECSM3 3

External Ids for CD93 Gene

Previous HGNC Symbols for CD93 Gene

  • MXRA4
  • C1QR1

Previous GeneCards Identifiers for CD93 Gene

  • GC20M023008
  • GC20M023059

Summaries for CD93 Gene

Entrez Gene Summary for CD93 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD93 Gene

CD93 (CD93 Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and B Cell Development Pathways. GO annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is THBD.

UniProtKB/Swiss-Prot for CD93 Gene

  • Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Gene Wiki entry for CD93 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD93 Gene

Genomics for CD93 Gene

Regulatory Elements for CD93 Gene

Enhancers for CD93 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G023141 2.1 FANTOM5 Ensembl ENCODE dbSUPER 44 -65.7 -65670 22.0 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARID4B DMAP1 YBX1 SLC30A9 ZNF766 CD93 THBD NXT1 ENSG00000230387 GZF1 CST3 ENSG00000279164 LOC100505664
GH20G023129 1.8 FANTOM5 Ensembl ENCODE dbSUPER 38.7 -45.5 -45473 5.6 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 ZMIZ1 FOS CD93 ENSG00000234832 NXT1 ENSG00000230387 THBD GZF1 LINC00656
GH20G023135 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.6 -50.7 -50660 3.1 FOS CAVIN1 GTF2B JUNB REST ZNF592 CREB3 SMARCA4 MYNN NR2C1 CD93 NXT1 ENSG00000234832 ENSG00000230387 LINC00656 ENSG00000279164
GH20G023119 1.4 FANTOM5 Ensembl ENCODE dbSUPER 33 -33.3 -33295 1.1 ZNF263 CTBP1 GLIS1 DPF2 RCOR1 EMSY MAFK NR2F2 CD93 THBD GZF1 LINC00656
GH20G023102 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.3 -18.7 -18698 5.9 CTCF JUN ETV1 TAL1 MAX ZIC2 RAD21 YY1 TCF12 EGR1 CD93 THBD GZF1 LINC00656
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD93 on UCSC Golden Path with GeneCards custom track

Promoters for CD93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000135618 540 401 BHLHE40 NR2F1 ZFP64 TCF7 MAX CREM ZIC2

Genomic Location for CD93 Gene

Chromosome:
20
Start:
23,079,349 bp from pter
End:
23,086,340 bp from pter
Size:
6,992 bases
Orientation:
Minus strand

Genomic View for CD93 Gene

Genes around CD93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD93 Gene

Proteins for CD93 Gene

  • Protein details for CD93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPY3-C1QR1_HUMAN
    Recommended name:
    Complement component C1q receptor
    Protein Accession:
    Q9NPY3
    Secondary Accessions:
    • O00274

    Protein attributes for CD93 Gene

    Size:
    652 amino acids
    Molecular mass:
    68560 Da
    Quaternary structure:
    • Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.

neXtProt entry for CD93 Gene

Post-translational modifications for CD93 Gene

Other Protein References for CD93 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CD93

Protein Products

Assay Products

  • Cloud-Clone Corp Assay Kits for CD93

No data available for DME Specific Peptides for CD93 Gene

Domains & Families for CD93 Gene

Suggested Antigen Peptide Sequences for CD93 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD93: view

No data available for UniProtKB/Swiss-Prot for CD93 Gene

Function for CD93 Gene

Molecular function for CD93 Gene

UniProtKB/Swiss-Prot Function:
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Gene Ontology (GO) - Molecular Function for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 11781389
GO:0004872 receptor activity NAS 9047234
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15459234
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD93: view
genes like me logo Genes that share phenotypes with CD93: view

Animal Models for CD93 Gene

MGI Knock Outs for CD93:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD93

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD93 Gene

Localization for CD93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD93 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD93 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IC 9047234
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CD93: view

Pathways & Interactions for CD93 Gene

genes like me logo Genes that share pathways with CD93: view

Pathways by source for CD93 Gene

Gene Ontology (GO) - Biological Process for CD93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis NAS 9047234
GO:0007155 cell adhesion IEA --
GO:0016032 viral process IEA --
GO:0016337 single organismal cell-cell adhesion IDA 11994479
GO:0042116 macrophage activation NAS 9047234
genes like me logo Genes that share ontologies with CD93: view

No data available for SIGNOR curated interactions for CD93 Gene

Drugs & Compounds for CD93 Gene

(1) Drugs for CD93 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CD93 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD93: view

Transcripts for CD93 Gene

mRNA/cDNA for CD93 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD93 Gene

CD93 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD93 Gene

No ASD Table

Relevant External Links for CD93 Gene

GeneLoc Exon Structure for
CD93
ECgene alternative splicing isoforms for
CD93

Expression for CD93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD93 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD93 Gene

This gene is overexpressed in Whole Blood (x5.5) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for CD93 Gene

This gene is overexpressed in Plasma (20.5), Monocytes (13.5), and Serum (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD93 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD93 Gene:

CD93

SOURCE GeneReport for Unigene cluster for CD93 Gene:

Hs.97199

mRNA Expression by UniProt/SwissProt for CD93 Gene:

Q9NPY3-C1QR1_HUMAN
Tissue specificity: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Evidence on tissue expression from TISSUES for CD93 Gene

  • Blood(4.5)
  • Heart(2.4)
  • Intestine(2.4)
  • Bone marrow(2.2)
  • Spleen(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CD93: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD93 Gene

Orthologs for CD93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD93 34 35
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia CD93 34 35
  • 77.83 (n)
cow
(Bos Taurus)
Mammalia CD93 34 35
  • 77.33 (n)
mouse
(Mus musculus)
Mammalia Cd93 34 16 35
  • 73.45 (n)
rat
(Rattus norvegicus)
Mammalia Cd93 34
  • 72.51 (n)
oppossum
(Monodelphis domestica)
Mammalia CD93 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD93 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD93 34 35
  • 54.38 (n)
lizard
(Anolis carolinensis)
Reptilia CD93 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd93 34
  • 52.45 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882826 34
  • 45.33 (n)
CD93 35
  • 31 (a)
OneToOne
Species where no ortholog for CD93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD93 Gene

ENSEMBL:
Gene Tree for CD93 (if available)
TreeFam:
Gene Tree for CD93 (if available)

Paralogs for CD93 Gene

Paralogs for CD93 Gene

genes like me logo Genes that share paralogs with CD93: view

Variants for CD93 Gene

Sequence variations from dbSNP and Humsavar for CD93 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs138932459 A colorectal cancer sample 23,085,534(+) TGGCC(A/G)CAGAG nc-transcript-variant, reference, missense
rs1000097678 -- 23,080,869(+) ATTGT(C/T)GATAA intron-variant, utr-variant-3-prime
rs1000302257 -- 23,080,615(+) GCCGA(C/T)AGTGA intron-variant, utr-variant-3-prime
rs1000470607 -- 23,084,967(+) AGGAG(C/T)AGTGA nc-transcript-variant, reference, missense
rs1000668220 -- 23,078,605(+) GTTCA(C/T)ATCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD93 Gene

Variant ID Type Subtype PubMed ID
esv2758789 CNV loss 17122850
esv3567923 CNV loss 25503493
nsv526474 CNV loss 19592680

Variation tolerance for CD93 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD93 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD93 Gene

Disorders for CD93 Gene

Relevant External Links for CD93

Genetic Association Database (GAD)
CD93
Human Genome Epidemiology (HuGE) Navigator
CD93
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD93

No disorders were found for CD93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD93 Gene

Publications for CD93 Gene

  1. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. (PMID: 9047234) Nepomuceno R.R. … Tenner A.J. (Immunity 1997) 2 3 4 22 64
  2. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net J.B. … Sijbrands E.J. (Eur. Heart J. 2008) 3 22 46 64
  3. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. (PMID: 11781389) Steinberger P. … Knapp W. (J. Leukoc. Biol. 2002) 3 4 22 64
  4. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. (PMID: 11994479) McGreal E.P. … Gasque P. (J. Immunol. 2002) 3 4 22 64
  5. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (PMID: 10092817) Nepomuceno R.R. … Tenner A.J. (J. Immunol. 1999) 3 4 22 64

Products for CD93 Gene

Sources for CD93 Gene

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