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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD9 Gene

protein-coding GIFtS: 65
GCID: GC12P006308

CD9 molecule

(Previous name: CD9 antigen (p24) )
(Previous symbol: MIC3)

Explore 98 diseases affiliated with
CD9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD9 Molecule¹ ²		BTCC-1²
MIC3¹ ² ³ ⁵		DRAP-27²
MRP-1¹ ² ³		TSPAN-29²
TSPAN29¹ ² ³		BA-2/P24 Antigen²
CD9 Antigen (P24)¹ ²		Motility Related Protein-1²
Cell Growth-Inhibiting Gene 2 Protein² ³		Tetraspanin-29³
Leukocyte Antigen MIC3² ³		Tetraspanin-29³
5H9 Antigen² ³		Tspan-29³
CD9 Antigen² ³		Motility-Related Protein³
BA2¹		P24¹
P24¹

External Ids:	HGNC: 1709¹	Entrez Gene: 928²	Ensembl: ENSG00000010278⁷	OMIM: 143030⁵	UniProtKB: P21926³

Export aliases for CD9 gene to outside databases

Previous GC identifers: GC12P006164 GC12P006284 GC12P006179

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD9:

This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are

cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface

proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal

transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and

metastasis. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: CD9_HUMAN, P21926

Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell

adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion

Gene Wiki entry for CD9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD9 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-1 E2F STAT3 E2F-2 NF-kappaB1 Egr-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD9 promoter sequence

Search SABiosciences Chromatin IP Primers for CD9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

CD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD9 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006308: view genomic region (about GC identifiers)

Start:	6,308,881 bp from pter	End:	6,347,427 bp from pter
Size:	38,547 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD9_HUMAN, P21926 (See protein sequence)

Recommended Name: CD9 antigen

Size: 228 amino acids; 25416 Da

Subunit: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members

of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: D3DUQ9 Q5J7W6 Q96ES4

Explore the universe of human proteins at neXtProt for CD9: NX_P21926

Post-translational modifications:

Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked

fatty acids¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21926

CD9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001760.1

ENSEMBL proteins:

ENSP00000371958 ENSP00000440985 ENSP00000371959 ENSP00000009180 ENSP00000371955

Reactome Protein details: P21926
Human Recombinant Protein Products for CD9:

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	Novus Biologicals CD9 Proteins Novus Biologicals CD9 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	2037603
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	--	--
GO:0016021	integral to membrane	--	--

CD9 for ontologies About GeneDecksing

CD9 Antibody Products:

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	ThermoFisher Antibody for CD9

Assay Products for CD9:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD9
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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD9 for domains About GeneDecksing

4 InterPro domains/families:

IPR018499 Tetraspanin/Peripherin

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

IPR018503 Tetraspanin_CS

Graphical View of Domain Structure for InterPro Entry P21926

ProtoNet protein and cluster: P21926

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: CD9_HUMAN, P21926

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD9_HUMAN, P21926

Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell

adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion

Genatlas biochemistry entry for CD9:

cell differentiation antigen CD9 (p34),24kDa,membrane glycoprotein,single chain,identified by monoclonal antibodies

ALB6,BLI16,FMC56

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IPI	11504738

CD9 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CD9:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

Synthetic lethal with paclitax

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd9):

growth/size	hematopoietic system	immune system	reproductive system	respiratory system
skeleton

CD9 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CD9: Cd9^tm1Kudo Cd9^tm1Bcx Cd9^tm1Mek

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD9

miRNA Products:		OriGene 3'-UTR Clone: CD9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD9
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD9:
		hsa-miR-338-5p hsa-miR-3924
		SwitchGear 3'UTR luciferase reporter plasmid: CD9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD9 (see all 7) OriGene shRNA RFP: CD9 OriGene siRNA: CD9
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD9
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD9 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

a6b1 and a6b4 Integrin signaling

a6b1 and a6b4 Integrin signaling

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CD9

a6b1 and a6b4 Integrin signaling

4 Reactome Pathways for CD9

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

1 Kegg Pathway (Kegg details for CD9):

Hematopoietic cell lineage

CD9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for CD9 (P21926^{2, 3} ENSP00000009180⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD19	P15391²^,³, ENSP00000313419⁴	MINT-8407185 I2D: score=3 STRING: ENSP00000313419
CD63	P08962²^,³, ENSP00000257857⁴	MINT-8407185 I2D: score=3 STRING: ENSP00000257857
IGSF8	Q969P0²^,³, ENSP00000316664⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000316664
PTGFRN	Q9P2B2²^,³, ENSP00000376899⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000376899
MME	P08473²	MINT-8407259 MINT-8406803 MINT-8406837 MINT-8406823 MINT-8406857 MINT-8407185

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006928	cellular component movement	IDA	8478605
GO:0007155	cell adhesion	IDA	7511626
GO:0007342	fusion of sperm to egg plasma membrane	IDA	14575715
GO:0007420	brain development	IEA	--

CD9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD9
10/67 Novoseek chemical compound relationships for CD9 gene (see all 67) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zidovudine	82.9	48	7632462 (3), 2120599 (2), 8097095 (2), 1291319 (2) (see all 33)
didanosine	75.4	13	2139173 (1), 1510405 (1), 8426301 (1), 1347442 (1) (see all 10)
neopterin	67.6	29	2214610 (3), 7529507 (2), 8097095 (2), 2126281 (2) (see all 24)
curdlan sulfate	66.6	1	1676899 (1)
3'-fluoro-3'-deoxythymidine	51.3	1	7995977 (1)
emulphor	48.5	2	12705892 (1), 9804823 (1)
diethyl dithiocarbamate	46.6	3	7840911 (1), 2159703 (1), 1281077 (1)
nevirapine	39.5	4	7530585 (2), 8195615 (1), 8780818 (1)
mdms	37.1	2	9568543 (1), 11897037 (1)
foscarnet	31.4	3	1323624 (2), 7658051 (1)

Search CenterWatch for drugs/clinical trials and news about CD9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD9 gene:

NM_001769.3

Unigene Cluster for CD9:

CD9 molecule

Hs.114286 [show with all ESTs]

Unigene Representative Sequence: AK025016

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382518(uc001qnq.2) ENST00000543916 ENST00000536586 ENST00000382519(uc010sev.2)

ENST00000546073(uc010seu.2) ENST00000538834 ENST00000538418 ENST00000009180

ENST00000382515 ENST00000481267 ENST00000540891

miRNA Products:		OriGene 3'-UTR Clone: CD9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD9
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD9:
		hsa-miR-338-5p hsa-miR-3924
		SwitchGear 3'UTR luciferase reporter plasmid: CD9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD9 (see all 7) OriGene shRNA RFP: CD9 OriGene siRNA: CD9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD9
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD9 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD9 (NM_001769)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD9

Additional cDNA sequence:

AB079244.1 AK025016.1 AK308700.1 AK311020.1 AK315219.1 AY423720.1 AY966455.1 BC011988.1

HM245393.1 L34068.1 M38690.1 X60111.1

24/27 DOTS entries (see all 27):

DT.100849778 DT.453110 DT.100849783 DT.95222449 DT.95214031 DT.121110412 DT.121110457 DT.91867150

DT.97860873 DT.100849774 DT.100031871 DT.95193123 DT.121110448 DT.121110399 DT.121110410 DT.100849776

DT.121110346 DT.121110398 DT.95213964 DT.95214018 DT.95214065 DT.97777276 DT.121110327 DT.121110426

9 AceView cDNA sequences:

CR598565 X60111 CR619299 BC011988 L34068 NM_001769 CR599322 CR599016

M38690

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD9 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12
SP1:													-				-				-		-
SP2:													-				-				-
SP3:							-						-				-				-		-
SP4:																	-				-		-
SP5:																					-		-

ECgene alternative splicing isoforms for CD9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGATTGGTG

About this image

CD9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Amnion

Amniotic Membrane

Amniotic Cells

Selective marker (cell-identifying gene)

Amnion, Extraembryonic Tissues

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Ovary

Ovigerous Cord

Ovum

Female Gametocytes, Germ Cells

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

Endometrial regenerative cell (Adult Stem / Progenitor Cell)

Reproductive System

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

See CD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD9

SOURCE GeneReport for Unigene cluster: Hs.114286

UniProtKB/Swiss-Prot: CD9_HUMAN, P21926

Tissue specificity: Expressed by a variety of hematopoietic and epithelial cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CD9:

Multiple Sclerosis in human mouse rat

Embryonic Stem Cells in human mouse rat

Osmotic Stress in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD9
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD9 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CD9¹	CD9 molecule	72.2(n) 73.99(a)		395527 NM_204762.1 NP_990093.1
lizard (Anolis carolinensis)	Reptilia	CD9⁶	--	51(a)	1 ↔ 1	5(82042704-82061825)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24740²	Xenopus laevis transcribed sequence with moderate similarity more	79.51(n)		CD303099.1
zebrafish (Danio rerio)	Actinopterygii	Dr.27131²	Danio rerio cDNA clone MGC73383 IMAGE4200844, complete more	76(n)		BC059691.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp96F⁶	Tetraspanin 96F	22(a)	1 → many	3R(21698564-21707162)
worm (Caenorhabditis elegans)	Secernentea	tsp-9¹	Protein TSP-9	44.23(n) 29.76(a)		180472 NM_075831.3 NP_508232.1

ENSEMBL Gene Tree for CD9 (if available)
TreeFam Gene Tree for CD9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD9 gene

TSPAN2² CD81²

15 SIMAP similar genes for CD9 using alignment to 4 protein entries: CD9_HUMAN (see all proteins):

BTCC-1 CD81 CD82 TSPAN5 TSPAN2 TSPAN18

TSPAN8 CD151 CD63 TSPAN4 CD53 TSPAN12

CD37 TSPAN9 TSPAN11

CD9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs25606^1,2	C	--	6307485(-)	`GAGAT-/CAGAGG CAGAG`	1	--	us2k¹ tfbs³		0	--	--	--	--
rs149319150^1,2	C	--	6307485(+)	`CTCTGA/C/GCTCTG`	1	--	us2k¹		0	--	--	--	--
rs186051096^1,2		--	6307510(+)	`TTCCCA/GGCCTG`	1	--	us2k¹		0	--	--	--	--
rs3181288^1,2		--	6307549(+)	`TCTAGC/GCTTTA`	1	--	us2k¹		1		CSA	1
rs797773^1,2	C,F,O,A,H	--	6307566(+)	`TGCCCC/TGCCTT`	1	--	us2k¹		23		MN NS EA NA WA CSA	2946
rs147738415^1,2		--	6307589(+)	`TCTCAC/TCTGAA`	1	--	us2k¹		0	--	--	--	--
rs148832034^1,2		--	6307680(+)	`ATTGCA/GTCTCC`	1	--	us2k¹		0	--	--	--	--
rs75659658^1,2	F	--	6307714(+)	`CATGCA/CATCCC`	1	--	us2k¹		1		EA	120
rs189645137^1,2		--	6307744(+)	`ACTGGA/GGATGC`	1	--	us2k¹		0	--	--	--	--
rs142504017^1,2		--	6307752(+)	`TGCCAA/GCAATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD9 (6308881 - 6347427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD9

DNA2.0 Custom Variant and Variant Library Synthesis for CD9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CD9 for disorders           About GeneDecksing

OMIM gene information: 143030    OMIM disorders: --

20/98 diseases for CD9 (see all 98):    About MalaCards

glanzmann's thrombasthenia progressive multifocal leukoencephalopathy thrombotic thrombocytopenic purpura herpes zoster

aids dementia complex thrombasthenia oral candidiasis status epilepticus

chromophobe renal cell carcinoma kaposi's sarcoma acute non lymphoblastic leukemia gastrointestinal stromal tumor

squamous cell carcinoma lymphoblastic leukemia mycobacterial infection candidiasis

cutaneous malignant melanoma adenoid cystic carcinoma oral squamous cell carcinoma acquired immunodeficiency syndrome

1 disease from the University of Copenhagen DISEASES database for CD9:

Leukemia

10/72 Novoseek disease relationships for CD9 gene (see all 72) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	87.2	157	9419745 (2), 12624024 (2), 1677177 (2), 1323624 (2) (see all 99)
hiv infections	82.2	83	9403423 (3), 14646380 (2), 8207645 (2), 8604210 (2) (see all 71)
aids-related complex	81.9	5	1506978 (1), 2123627 (1), 8811465 (1), 1974725 (1)
aids	73.7	82	10609356 (3), 11766280 (2), 1351128 (2), 11109648 (2) (see all 59)
viremia	63.2	13	7906292 (1), 9845513 (1), 14646380 (1), 8097416 (1) (see all 13)
pediatric aids	56.5	2	9041402 (1), 9420321 (1)
opportunistic infections	53	2	2227628 (1), 9586886 (1)
virus infection	52.2	19	8655993 (1), 14872188 (1), 2186629 (1), 2227628 (1) (see all 19)
vertical transmission	51.4	3	8784370 (1), 8161446 (1), 8280414 (1)
kaposi sarcoma	36.5	2	14559986 (2)

Human Genome Epidemiology (HuGE) Navigator: CD9 (3 documents)

Export disorders for CD9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD9 gene, integrated from 9 sources (see all 677):
(articles sorted by number of sources associating them with CD9)

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Organization of the human CD9 gene. (PubMed id 8486348)^{1, 2, 9} Rubinstein E.... Boucheix C. (1993)
Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. (PubMed id 14556650)^{1, 2, 9} Kovalenko O.V.... Hemler M.E. (2004)
Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120)^{1, 2, 9} Charrin S....Rubinstein E. (2002)
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. (PubMed id 8478605)^{1, 2, 9} Ikeyama S.... Miyake M. (1993)
Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. (PubMed id 1720807)^{1, 2, 9} Miyake M.... Ikeyama S. (1991)
Molecular cloning of the CD9 antigen. A new family of cell surface proteins. (PubMed id 1840589)^{1, 2, 9} Boucheix C.... Uzan G. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation. (PubMed id 15196249)^{1, 2} Kobayashi H.... Morimoto C. (2004)
Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. (PubMed id 14575715)^{1, 2} Higginbottom A.... Monk P.N. (2003)
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)^{1, 2} Stipp C.S.... Hemler M.E. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 928	HGNC: 1709	AceView: CD9	Ensembl:ENSG00000010278	euGenes: HUgn928
ECgene: CD9	Kegg: 928	H-InvDB: CD9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD9	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/cd9/

Intellectual Property for CD9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD9 gene:
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GeneCards and IP:
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CD9 (Gene Symbol)
CD9 Molecule
MIC3
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TSPAN29
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Cell Growth-Inhibiting Gene 2 Protein
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Motility Related Protein-1
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Motility-Related Protein
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