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CD9 Gene

protein-coding   GIFtS: 67
GCID: GC12P006308

CD9 Molecule

(Previous name: CD9 antigen (p24))
(Previous symbol: MIC3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD9 Molecule1 2     BTCC-12
MIC31 2 3 5     DRAP-272
CD9 Antigen (P24)1 2     TSPAN-292
Motility Related Protein-11 2     BA-2/P24 Antigen2
Cell Growth-Inhibiting Gene 2 Protein2 3     tetraspanin-292
Leukocyte Antigen MIC32 3     Tetraspanin-293
5H9 Antigen2 3     Tspan-293
MRP-12 3     Motility-Related Protein3
TSPAN292 3     p243
CD9 Antigen2 3     

External Ids:    HGNC: 17091   Entrez Gene: 9282   Ensembl: ENSG000000102787   OMIM: 1430305   UniProtKB: P219263   

Export aliases for CD9 gene to outside databases

Previous GC identifers: GC12P006164 GC12P006284 GC12P006179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD9 Gene:
This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins
are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell
surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion,
and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell
motility and metastasis. (provided by RefSeq, Jan 2011)

GeneCards Summary for CD9 Gene:
CD9 (CD9 molecule) is a protein-coding gene. Diseases associated with CD9 include acute non lymphoblastic leukemia, and acquired immunodeficiency syndrome. GO annotations related to this gene include integrin binding. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD9_HUMAN, P21926
Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in
cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion

Gene Wiki entry for CD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD9 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F   STAT3   E2F-2   NF-kappaB1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD9 promoter sequence
   Search Chromatin IP Primers for CD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006308:  view genomic region     (about GC identifiers)

Start:
6,308,881 bp from pter      End:
6,347,437 bp from pter
Size:
38,557 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD9_HUMAN, P21926 (See protein sequence)
Recommended Name: CD9 antigen  
Size: 228 amino acids; 25416 Da
Subunit: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other
members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8
Secondary accessions: D3DUQ9 Q5J7W6 Q96ES4

Explore the universe of human proteins at neXtProt for CD9: NX_P21926

Explore proteomics data for CD9 at MOPED

Post-translational modifications: 

  • Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked
    fatty acids1
  • Glycosylation2 at Asn52, Asn53
  • Modification sites at PhosphoSitePlus

  • See CD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001760.1  
    ENSEMBL proteins: 
     ENSP00000371958   ENSP00000440985   ENSP00000371959   ENSP00000009180   ENSP00000371955  
    Reactome Protein details: P21926

    CD9 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    CD9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD9
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    CD9 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P21926

    ProtoNet protein and cluster: P21926

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD9_HUMAN, P21926
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD9_HUMAN, P21926
    Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in
    cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion

         Genatlas biochemistry entry for CD9:
    cell differentiation antigen CD9 (p34),24kDa,membrane glycoprotein,single chain,identified by monoclonal
    antibodies ALB6,BLI16,FMC56

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI11278880
         
    CD9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CD9:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Synthetic lethal with paclitax 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd9):
     growth/size/body  hematopoietic system  immune system  reproductive system  respiratory system 
     skeleton 

    CD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD9: Cd9tm1Kudo Cd9tm1Bcx Cd9tm1Mek

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD9

    miRNA
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    miRTarBase miRNAs that target CD9:
    hsa-mir-326 (MIRT019530), hsa-mir-335-5p (MIRT018296)

    Block miRNA regulation of human, mouse, rat CD9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD9:
    hsa-miR-338-5p hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidCD9 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CD9 (NM_001769)
    Sino Biological Human cDNA Clone for CD9
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD9_HUMAN, P21926: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endosome2
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS2037603
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane ----

    CD9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD9 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Sperm-Oocyte Membrane Binding0.00
    Fertilization1.00
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Hematopoietic cell lineage
    Hematopoietic cell lineage
    5a6b1 and a6b4 Integrin signaling
    a6b1 and a6b4 Integrin signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD9
        a6b1 and a6b4 Integrin signaling


    2 Reactome Pathways for CD9
        Platelet degranulation
    Sperm:Oocyte Membrane Binding


    1 Kegg Pathway  (Kegg details for CD9):
        Hematopoietic cell lineage


    CD9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD9: 
              Multiple Sclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD9 (P219261, 2, 3 ENSP000000091804) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084731, 2EBI-4280101,EBI-353759 MINT-8407259 MINT-8406803 MINT-8406837 MINT-8406823 MINT-8406857 MINT-8407185
    CD19P153912, 3, ENSP000003134194MINT-8407185 I2D: score=3 STRING: ENSP00000313419
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=3 STRING: ENSP00000257857
    IGSF8Q969P02, 3, ENSP000003166644MINT-8407185 I2D: score=2 STRING: ENSP00000316664
    PTGFRNQ9P2B22, 3, ENSP000003768994MINT-8407185 I2D: score=2 STRING: ENSP00000376899
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006928cellular component movement IDA8478605
    GO:0007155cell adhesion IDA7511626
    GO:0007338single fertilization TAS--
    GO:0007342fusion of sperm to egg plasma membrane TAS--

    CD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD9

    Selected Novoseek inferred chemical compound relationships for CD9 gene (see all 67)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zidovudine 82.9 48 7632462 (3), 2120599 (2), 8097095 (2), 1291319 (2) (see all 33)
    didanosine 75.4 13 2139173 (1), 1510405 (1), 8426301 (1), 1347442 (1) (see all 10)
    neopterin 67.6 29 2214610 (3), 7529507 (2), 8097095 (2), 2126281 (2) (see all 24)
    curdlan sulfate 66.6 1 1676899 (1)
    3'-fluoro-3'-deoxythymidine 51.3 1 7995977 (1)
    emulphor 48.5 2 12705892 (1), 9804823 (1)
    diethyl dithiocarbamate 46.6 3 7840911 (1), 2159703 (1), 1281077 (1)
    nevirapine 39.5 4 7530585 (2), 8195615 (1), 8780818 (1)
    mdms 37.1 2 9568543 (1), 11897037 (1)
    foscarnet 31.4 3 1323624 (2), 7658051 (1)



    CD9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD9 gene: 
    NM_001769.3  

    Unigene Cluster for CD9:

    CD9 molecule
    Hs.114286  [show with all ESTs]
    Unigene Representative Sequence: AK025016
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382518(uc001qnq.2) ENST00000543916 ENST00000536586 ENST00000382519(uc010sev.2)
    ENST00000546073(uc010seu.2) ENST00000538834 ENST00000538418 ENST00000009180
    ENST00000382515 ENST00000481267 ENST00000540891
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CD9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD9:
    hsa-miR-338-5p hsa-miR-3924
    SwitchGear 3'UTR luciferase reporter plasmidCD9 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CD9
      QuantiFast Probe-based Assays in human, mouse, rat CD9

    Additional mRNA sequence: 

    AB079244.1 AK025016.1 AK308700.1 AK311020.1 AK315219.1 AY423720.1 AY966455.1 BC011988.1 
    HM245393.1 L34068.1 M38690.1 X60111.1 

    Selected DOTS entries (see all 27):

    DT.100849778  DT.453110  DT.100849783  DT.95222449  DT.95214031  DT.121110412  DT.121110457  DT.91867150 
    DT.97860873  DT.100849774  DT.100031871  DT.95193123  DT.121110448  DT.121110399  DT.121110410  DT.100849776 
    DT.121110346  DT.121110398  DT.95213964  DT.95214018  DT.95214065  DT.97777276  DT.121110327  DT.121110426 

    9 AceView cDNA sequences:

    NM_001769 L34068 X60111 CR598565 BC011988 CR599016 CR619299 CR599322 
    M38690 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD9 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
    SP1:                                      -           -           -     -                                                   
    SP2:                                      -           -           -                                                         
    SP3:                    -                 -           -           -     -                                                   
    SP4:                                                  -           -     -                                                   
    SP5:                                                              -     -                                                   


    ECgene alternative splicing isoforms for CD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATTGGTG
    CD9 Expression
    About this image


    CD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 32) fully expand
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Zeugopod Periosteum
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Zeugopod Periosteum
    CD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114286

    UniProtKB/Swiss-Prot: CD9_HUMAN, P21926
    Tissue specificity: Expressed by a variety of hematopoietic and epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD9: 
              Multiple Sclerosis in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CD9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd91 , 5 CD9 antigen1, 5 85.99(n)1
    89.82(a)1
      6 (59.32 cM)5
    125271  NM_007657.31  NP_031683.11 
     1254602665 
    chicken
    (Gallus gallus)
    Aves CD91 CD9 molecule 72.2(n)
    73.99(a)
      395527  NM_204762.1  NP_990093.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD96
    CD9 molecule
    50(a)
    1 ↔ 1
    5(82042704-82061825)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247402 Xenopus laevis transcribed sequence with moderate similarity more 79.51(n)    CD303099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271312 Danio rerio cDNA clone MGC73383 IMAGE4200844, complete more 76(n)    BC059691.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp96F6
    Tetraspanin 96F
    24(a)
    1 → many
    3R(21698564-21707162)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-96
    Protein TSP-9 (tsp-9) mRNA, complete cds
    26(a)
    1 → many
    X(1246017-1247499) WBGene00006635


    ENSEMBL Gene Tree for CD9 (if available)
    TreeFam Gene Tree for CD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD9 gene
    TSPAN22  TSPAN12  CD372  TSPAN92  CD532  CD822  TSPAN182  CD812  
    TSPAN42  TSPAN82  
    14 SIMAP similar genes for CD9 using alignment to 4 protein entries:     CD9_HUMAN (see all proteins):
    BTCC-1    CD81    CD82    TSPAN5    TSPAN2    TSPAN18
    TSPAN8    CD151    CD63    TSPAN4    CD53    TSPAN12
    CD37    TSPAN9

    CD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD9 (see all 919)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs256061,2
    C--6307485(-) GAGAT-/CAGAGG
            
    CAGAG
    1 -- us2k1 tfbs30--------
    rs1493191501,2
    C--6307485(+) CTCTGA/C/GCTCTG 1 -- us2k10--------
    rs1860510961,2
    --6307510(+) TTCCCA/GGCCTG 1 -- us2k10--------
    rs31812881,2
    C,F--6307549(+) TCTAGC/GCTTTA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs7977731,2
    C,F,O,A,H--6307566(+) TGCCCC/TGCCTT 1 -- us2k123Minor allele frequency- T:0.34MN NS EA NA WA CSA 2946
    rs1477384151,2
    C--6307589(+) TCTCAC/TCTGAA 1 -- us2k10--------
    rs1488320341,2
    C--6307680(+) ATTGCA/GTCTCC 1 -- us2k10--------
    rs756596581,2
    F--6307714(+) CATGCA/CATCCC 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1896451371,2
    --6307744(+) ACTGGA/GGATGC 1 -- us2k10--------
    rs1425040171,2
    --6307752(+) TGCCAA/GCAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD9 (6308881 - 6347437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD9:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1351n71CNV Loss21882294
    nsv832320CNV Loss17160897
    nsv470263CNV Gain18288195
    nsv832321CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD9
    DNA2.0 Custom Variant and Variant Library Synthesis for CD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 143030    OMIM disorders: --

    Selected diseases for CD9 (see all 93):    
    About MalaCards
    acute non lymphoblastic leukemia    acquired immunodeficiency syndrome    oral candidiasis    herpes zoster
    cytomegalovirus retinitis    thrombasthenia    glanzmann's thrombasthenia    thrombotic thrombocytopenic purpura
    candidiasis    progressive multifocal leukoencephalopathy    aids dementia complex    chromophobe renal cell carcinoma
    diphtheria    kaposi's sarcoma    lymphoid leukemia    status epilepticus
    hemophilia    cutaneous malignant melanoma    merkel cell carcinoma    lymphoblastic leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD9:
    Leukemia     Toxoplasmosis

    CD9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CD9 gene (see all 72)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 87.2 157 9419745 (2), 12624024 (2), 1677177 (2), 1323624 (2) (see all 99)
    hiv infections 82.2 83 9403423 (3), 14646380 (2), 8207645 (2), 8604210 (2) (see all 71)
    aids-related complex 81.9 5 1506978 (1), 2123627 (1), 8811465 (1), 1974725 (1)
    aids 73.7 82 10609356 (3), 11766280 (2), 1351128 (2), 11109648 (2) (see all 59)
    viremia 63.2 13 7906292 (1), 9845513 (1), 14646380 (1), 8097416 (1) (see all 13)
    pediatric aids 56.5 2 9041402 (1), 9420321 (1)
    opportunistic infections 53 2 2227628 (1), 9586886 (1)
    virus infection 52.2 19 8655993 (1), 14872188 (1), 2186629 (1), 2227628 (1) (see all 19)
    vertical transmission 51.4 3 8784370 (1), 8161446 (1), 8280414 (1)
    kaposi sarcoma 36.5 2 14559986 (2)

    Genetic Association Database (GAD): CD9
    Human Genome Epidemiology (HuGE) Navigator: CD9 (3 documents)

    Export disorders for CD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD9 gene, integrated from 10 sources (see all 690):
    (articles sorted by number of sources associating them with CD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human CD9 gene. (PubMed id 8486348)1, 2, 9 Rubinstein E.... Boucheix C. (Genomics 1993)
    2. Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. (PubMed id 14556650)1, 2, 9 Kovalenko O.V.... Hemler M.E. (Biochem. J. 2004)
    3. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120)1, 2, 9 Charrin S....Rubinstein E. (FEBS Lett. 2002)
    4. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. (PubMed id 8478605)1, 2, 9 Ikeyama S.... Miyake M. (J. Exp. Med. 1993)
    5. Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. (PubMed id 1720807)1, 2, 9 Miyake M.... Ikeyama S. (J. Exp. Med. 1991)
    6. Molecular cloning of the CD9 antigen. A new family of cell surface proteins. (PubMed id 1840589)1, 2, 9 Boucheix C.... Uzan G. (J. Biol. Chem. 1991)
    7. CD9 gene variations are not associated with female infertility in humans. (PubMed id 19955810)1, 4 Nishiyama S....Kurahashi H. (Gynecol. Obstet. Invest. 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation. (PubMed id 15196249)1, 2 Kobayashi H.... Morimoto C. (Clin. Exp. Immunol. 2004)
    10. Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. (PubMed id 14575715)1, 2 Higginbottom A.... Monk P.N. (Biochem. Biophys. Res. Commun. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 928 HGNC: 1709 AceView: CD9 Ensembl:ENSG00000010278 euGenes: HUgn928
    ECgene: CD9 Kegg: 928 H-InvDB: CD9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD9 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/cd9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD9 gene:
    Search GeneIP for patents involving CD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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