|
|
CD8b molecule pseudogene(Previous names: CD8 antigen, beta polypeptide 2, pseudogene (p37) )
(Previous symbol: CD8B2)
| |
Aliases
for CD8BP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD8b Molecule Pseudogene1 2 | | CD8B21 2 3 | | CD8 Antigen, Beta Polypeptide 2, Pseudogene (P37)1 | | CD8b Pseudogene3 |
Export aliases for CD8BP gene to outside databasesPrevious GC identifer: GC02P106470 |
Summaries
for CD8BP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CD8BL_HUMAN, A6NJW9Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought toplay a role in the process of T-cell mediated killing (By similarity)
|
Genomic Views
for CD8BP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CD8BP
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD8BP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD8BP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q12.1 Ensembl cytogenetic band: 2q12.2 HGNC cytogenetic band: 2q12.2CD8BP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P107103: view genomic region
(about GC identifiers)
Start:
|
107,103,824 bp from pter |
End:
|
107,124,137 bp from pter |
Size:
|
20,314 bases |
Orientation:
|
plus strand |
|
Proteins
for CD8BP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD8BL_HUMAN, A6NJW9 (See
protein sequence)Recommended Name: Putative T-cell surface glycoprotein CD8 beta-2 chain precursor Size: 211 amino acids; 23768 Da
Subunit: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Caution: Could be the product of a pseudogene. According to PubMed:1541829, the gene appears functional but all themRNAs identified are derived from CD8B/CD8B1Explore the universe of human proteins at neXtProt for CD8BP: NX_A6NJW9
CD8BP Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CD8BP for ontologies About GeneDecksing
CD8BP Antibody Products:
Assay Products for CD8BP: |
Protein
Domains /
Families
for CD8BP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD8BP for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJW9ProtoNet protein and cluster: A6NJW9 UniProtKB/Swiss-Prot: CD8BL_HUMAN, A6NJW9Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for CD8BP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CD8BL_HUMAN, A6NJW9Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought toplay a role in the process of T-cell mediated killing (By similarity)
|
Pathways & Interactions
for CD8BP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD8BP
|
Drugs & Compounds
for CD8BP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CD8BP
Search CenterWatch for drugs/clinical trials and news about CD8BP 
|
Transcripts
for CD8BP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416057 ENST00000417670 ENST00000446559 ENST00000303432
3 AceView cDNA sequences: AW611750 AA514840 BQ349603
GeneLoc Exon Structure
|
Expression
for CD8BP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD8BP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CD8BP Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for CD8BP
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CD8BP | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD8BP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD8BP |
Orthologs
for CD8BP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CD8BP (if available)
TreeFam Gene Tree for CD8BP (if available) |
Paralogs
for CD8BP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CD8BP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CD8BP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD8BP for disorders About GeneDecksing
1  disease for CD8BP: About MalaCardslymphosarcoma
1 disease from the University of Copenhagen DISEASES database for CD8BP:Lymphosarcoma Export disorders for CD8BP gene to outside databases
|
Publications
for CD8BP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD8BP gene integrated from 9 sources:
(articles sorted by number of sources associating them with CD8BP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recent duplication of the two human CD8 beta-chain genes. (PubMed id 1541829)1, 2, 3 Nakayama K.... Nakauchi H. (1992)
- Transcriptional diversity at the duplicated human CD8 beta loci. (PubMed id 8436166)1, 2 DiSanto J.P.... Flomenberg N. (1993)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Chromosomal mapping of the second human CD8B gene locus. (PubMed id 8575821)1 Zhang X.L....Chamberlain J.W. (1996)
- Duplication of the CD8 beta-chain gene as a marker of the man-gorilla-chimpanzee clade. (PubMed id 8346216)1 Delarbre C....Gachelin G. (1993)
- Sequence and evolution of the human T-cell antigen receptor beta- chain genes. (PubMed id 3860845)1 Tunnacliffe A.... Rabbitts T.H. (1985)
|
External Searches for CD8BP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD8BP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD8BP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD8BP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD8BP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CD8BP gene:
Search GeneIP for patents involving CD8BP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD8BP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD8BP | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD8BP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD8BP | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD8BP | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD8BP | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD8BP |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CD8BP |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for CD8BP |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CD8BP |
|
|
|
|
