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Aliases for CD8B Gene

Aliases for CD8B Gene

  • CD8b Molecule 2 3
  • CD8 Antigen, Beta Polypeptide 1 (P37) 2 3
  • CD8B1 3 4
  • T Lymphocyte Surface Glycoprotein Beta Chain 3
  • CD8b Antigen 4
  • Leu2 3
  • LYT3 3
  • LY3 3
  • P37 3

External Ids for CD8B Gene

Previous HGNC Symbols for CD8B Gene

  • CD8B1

Previous GeneCards Identifiers for CD8B Gene

  • GC02M086895
  • GC02M087042

Summaries for CD8B Gene

Entrez Gene Summary for CD8B Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

GeneCards Summary for CD8B Gene

CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include mucinous stomach adenocarcinoma. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include coreceptor activity and MHC class I protein binding.

UniProtKB/Swiss-Prot for CD8B Gene

  • Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD8B Gene

Genomics for CD8B Gene

Regulatory Elements for CD8B Gene

Genomic Location for CD8B Gene

Chromosome:
2
Start:
86,815,337 bp from pter
End:
86,861,924 bp from pter
Size:
46,588 bases
Orientation:
Minus strand

Genomic View for CD8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8B Gene

Proteins for CD8B Gene

  • Protein details for CD8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10966-CD8B_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 beta chain
    Protein Accession:
    P10966
    Secondary Accessions:
    • P14860
    • P14861
    • Q15980
    • Q496E0
    • Q496E1
    • Q496E2
    • Q9UDB4
    • Q9UDB5
    • Q9UDB6
    • Q9UDB7
    • Q9UDB8
    • Q9UDB9
    • Q9UDC0
    • Q9UQ55

    Protein attributes for CD8B Gene

    Size:
    210 amino acids
    Molecular mass:
    23722 Da
    Quaternary structure:
    • In general heterodimer of an alpha and a beta chain linked by two disulfide bonds
    SequenceCaution:
    • Sequence=AAD13877.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CD8B Gene

neXtProt entry for CD8B Gene

Proteomics data for CD8B Gene at MOPED

Post-translational modifications for CD8B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD8B (CD8B)

No data available for DME Specific Peptides for CD8B Gene

Domains & Families for CD8B Gene

Gene Families for CD8B Gene

Protein Domains for CD8B Gene

Graphical View of Domain Structure for InterPro Entry

P10966

UniProtKB/Swiss-Prot:

CD8B_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD8B: view

Function for CD8B Gene

Molecular function for CD8B Gene

UniProtKB/Swiss-Prot Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing

Gene Ontology (GO) - Molecular Function for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2493728
GO:0015026 coreceptor activity NAS 11131152
GO:0042288 MHC class I protein binding NAS 11131152
genes like me logo Genes that share ontologies with CD8B: view
genes like me logo Genes that share phenotypes with CD8B: view

Animal Models for CD8B Gene

MGI Knock Outs for CD8B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD8B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD8B Gene

Localization for CD8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8B Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD8B Gene COMPARTMENTS Subcellular localization image for CD8B gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3

Gene Ontology (GO) - Cellular Components for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3145195
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
genes like me logo Genes that share ontologies with CD8B: view

Pathways & Interactions for CD8B Gene

genes like me logo Genes that share pathways with CD8B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006955 immune response NAS 11131152
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 9830036
GO:0016032 viral process TAS --
GO:0042110 T cell activation NAS 9830036
genes like me logo Genes that share ontologies with CD8B: view

No data available for SIGNOR curated interactions for CD8B Gene

Drugs & Compounds for CD8B Gene

No Compound Related Data Available

Transcripts for CD8B Gene

Unigene Clusters for CD8B Gene

CD8b molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD8B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD8B Gene

No ASD Table

Relevant External Links for CD8B Gene

GeneLoc Exon Structure for
CD8B
ECgene alternative splicing isoforms for
CD8B

Expression for CD8B Gene

mRNA expression in normal human tissues for CD8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD8B Gene

This gene is overexpressed in Whole Blood (x18.7), Cervix - Endocervix (x5.6), Spleen (x4.9), and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for CD8B Gene

This gene is overexpressed in CD8 Tcells (53.3) and Plasma (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD8B Gene



SOURCE GeneReport for Unigene cluster for CD8B Gene Hs.405667

mRNA Expression by UniProt/SwissProt for CD8B Gene

P10966-CD8B_HUMAN
Tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
genes like me logo Genes that share expression patterns with CD8B: view

Protein tissue co-expression partners for CD8B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD8B 35
  • 75.17 (n)
  • 63 (a)
CD8B 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD8B 35
  • 79.65 (n)
  • 63.95 (a)
CD8B 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd8b1 35
  • 70.69 (n)
  • 54.59 (a)
Cd8b1 16
Cd8b1 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD8B 35
  • 99.37 (n)
  • 99.05 (a)
CD8B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd8b 35
  • 68.43 (n)
  • 55.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CD8B 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves CD8B 36
  • 31 (a)
OneToOne
Species with no ortholog for CD8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD8B Gene

ENSEMBL:
Gene Tree for CD8B (if available)
TreeFam:
Gene Tree for CD8B (if available)

Paralogs for CD8B Gene

(3) SIMAP similar genes for CD8B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD8B Gene

genes like me logo Genes that share paralogs with CD8B: view

No data available for Paralogs for CD8B Gene

Variants for CD8B Gene

Sequence variations from dbSNP and Humsavar for CD8B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15704 -- 86,841,716(-) CTTCT(C/T)AGCTC intron-variant, utr-variant-3-prime
rs15741 -- 86,841,787(-) GNCAT(A/G)TCAGT intron-variant, utr-variant-3-prime
rs15800 -- 86,841,659(-) GGCTT(A/C)ATGCT intron-variant, utr-variant-3-prime
rs1126874 -- 86,846,694(-) GCCAT(C/G)CACCT intron-variant, reference, missense
rs1126875 -- 86,846,756(-) GCCCC(A/G)TCACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD8B Gene

Variant ID Type Subtype PubMed ID
nsv10063 CNV Gain 18304495
nsv874472 CNV Gain 21882294
esv25494 CNV Gain 19812545
nsv458585 CNV Gain 19166990
nsv7316 OTHER Inversion 18451855
nsv874473 CNV Gain 21882294
nsv516466 CNV Loss 19592680

Variation tolerance for CD8B Gene

Residual Variation Intolerance Score: 76.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD8B Gene

HapMap Linkage Disequilibrium report
CD8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8B Gene

Disorders for CD8B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD8B Gene - From: DISEASES

Disorder Aliases PubMed IDs
mucinous stomach adenocarcinoma
  • mucinous adenocarcinoma of the stomach
- elite association
Search CD8B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD8B

Genetic Association Database (GAD)
CD8B
Human Genome Epidemiology (HuGE) Navigator
CD8B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD8B
genes like me logo Genes that share disorders with CD8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD8B Gene

Publications for CD8B Gene

  1. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PMID: 11937547) Kieffer L.J. … Kavathas P.B. (J. Immunol. 2002) 23 67
  2. Recent duplication of the two human CD8 beta-chain genes. (PMID: 1541829) Nakayama K. … Nakauchi H. (J. Immunol. 1992) 2 67
  3. cAMP responsive element modulator (CREM) I+ mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. (PMID: 24297179) Hedrich C.M. … Tsokos G.C. (J. Biol. Chem. 2014) 67
  4. Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions. (PMID: 24495362) Heigele A. … Kirchhoff F. (Retrovirology 2014) 67
  5. cAMP-responsive element modulator I+ (CREMI+) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. (PMID: 24047902) Hedrich C.M. … Tsokos G.C. (J. Biol. Chem. 2013) 67

Products for CD8B Gene

Sources for CD8B Gene

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