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Aliases for CD8B Gene

Aliases for CD8B Gene

  • CD8b Molecule 2 3 5
  • CD8 Antigen, Beta Polypeptide 1 (P37) 2 3
  • CD8B1 3 4
  • T Lymphocyte Surface Glycoprotein Beta Chain 3
  • T-Cell Surface Glycoprotein CD8 Beta Chain 3
  • CD8b Antigen 4
  • Leu2 3
  • LYT3 3
  • P37 3
  • LY3 3

External Ids for CD8B Gene

Previous HGNC Symbols for CD8B Gene

  • CD8B1

Previous GeneCards Identifiers for CD8B Gene

  • GC02M086895
  • GC02M087042

Summaries for CD8B Gene

Entrez Gene Summary for CD8B Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

GeneCards Summary for CD8B Gene

CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Immune System Disease and Mucinous Stomach Adenocarcinoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include coreceptor activity and MHC class I protein binding.

UniProtKB/Swiss-Prot for CD8B Gene

  • Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD8B Gene

Genomics for CD8B Gene

Regulatory Elements for CD8B Gene

Enhancers for CD8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F086805 1.7 FANTOM5 Ensembl ENCODE 18.8 +54.1 54071 5.3 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 GATA2 CD8A CD8B SNORD94 CHMP3 RNU6-640P REEP1 PLGLB1 LOC105374846
GH02F086783 1.4 FANTOM5 Ensembl ENCODE 21.1 +72.5 72487 12.6 PKNOX1 ATF1 FEZF1 ZNF366 SCRT2 ZNF143 CREM JUNB REST TBX21 CD8A CD8B CHMP3 RNU6-640P REEP1 ENSG00000231259 RMND5A KDM3A RNF103 LOC105374846
GH02F086823 0.7 Ensembl ENCODE 5.1 +36.0 36024 4.6 MNT NR2F6 CHMP3 ENSG00000231259 CD8B CD8A ANAPC1P1
GH02F086824 0.4 Ensembl 4.9 +38.6 38624 0.2 SETDB1 ENSG00000231259 CD8B CD8A ANAPC1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD8B on UCSC Golden Path with GeneCards custom track

Promoters for CD8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001824732 223 1000

Genomic Location for CD8B Gene

Chromosome:
2
Start:
86,815,337 bp from pter
End:
86,861,924 bp from pter
Size:
46,588 bases
Orientation:
Minus strand

Genomic View for CD8B Gene

Genes around CD8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8B Gene

Proteins for CD8B Gene

  • Protein details for CD8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10966-CD8B_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 beta chain
    Protein Accession:
    P10966
    Secondary Accessions:
    • P14860
    • P14861
    • Q15980
    • Q496E0
    • Q496E1
    • Q496E2
    • Q9UDB4
    • Q9UDB5
    • Q9UDB6
    • Q9UDB7
    • Q9UDB8
    • Q9UDB9
    • Q9UDC0
    • Q9UQ55

    Protein attributes for CD8B Gene

    Size:
    210 amino acids
    Molecular mass:
    23722 Da
    Quaternary structure:
    • In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.
    SequenceCaution:
    • Sequence=AAD13877.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CD8B Gene

neXtProt entry for CD8B Gene

Post-translational modifications for CD8B Gene

No data available for DME Specific Peptides for CD8B Gene

Domains & Families for CD8B Gene

Gene Families for CD8B Gene

Protein Domains for CD8B Gene

Graphical View of Domain Structure for InterPro Entry

P10966

UniProtKB/Swiss-Prot:

CD8B_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD8B: view

Function for CD8B Gene

Molecular function for CD8B Gene

UniProtKB/Swiss-Prot Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

Gene Ontology (GO) - Molecular Function for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2493728
GO:0015026 coreceptor activity NAS 11131152
GO:0042288 MHC class I protein binding NAS 11131152
genes like me logo Genes that share ontologies with CD8B: view
genes like me logo Genes that share phenotypes with CD8B: view

Animal Models for CD8B Gene

MGI Knock Outs for CD8B:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD8B Gene

Localization for CD8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8B Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD8B gene
Compartment Confidence
plasma membrane 5
extracellular 4
endosome 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 3145195
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CD8B: view

Pathways & Interactions for CD8B Gene

genes like me logo Genes that share pathways with CD8B: view

Interacting Proteins for CD8B Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331172%0d%0a9606.ENSP00000332049%0d%0a9606.ENSP00000295756%0d%0a9606.ENSP00000264033%0d%0a9606.ENSP00000369293%0d%0a9606.ENSP00000339186%0d%0a
Selected Interacting proteins: ENSP00000331172 P10966-CD8B_HUMAN for CD8B Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-DRB1
B2M
CD247

Gene Ontology (GO) - Biological Process for CD8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response NAS 11131152
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 9830036
GO:0042110 T cell activation NAS 9830036
genes like me logo Genes that share ontologies with CD8B: view

No data available for SIGNOR curated interactions for CD8B Gene

Transcripts for CD8B Gene

Unigene Clusters for CD8B Gene

CD8b molecule:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD8B Gene

No ASD Table

Relevant External Links for CD8B Gene

GeneLoc Exon Structure for
CD8B
ECgene alternative splicing isoforms for
CD8B

Expression for CD8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD8B Gene

This gene is overexpressed in Whole Blood (x18.7), Cervix - Endocervix (x5.6), Spleen (x4.9), and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for CD8B Gene

This gene is overexpressed in CD8 Tcells (53.3) and Plasma (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD8B Gene



Protein tissue co-expression partners for CD8B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD8B Gene:

CD8B

SOURCE GeneReport for Unigene cluster for CD8B Gene:

Hs.405667

mRNA Expression by UniProt/SwissProt for CD8B Gene:

P10966-CD8B_HUMAN
Tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.
genes like me logo Genes that share expression patterns with CD8B: view

Primer Products

Orthologs for CD8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD8B 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia CD8B 34 35
  • 79.65 (n)
cow
(Bos Taurus)
Mammalia CD8B 34 35
  • 75.17 (n)
mouse
(Mus musculus)
Mammalia Cd8b1 34 16 35
  • 70.69 (n)
rat
(Rattus norvegicus)
Mammalia Cd8b 34
  • 68.43 (n)
oppossum
(Monodelphis domestica)
Mammalia CD8B 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves CD8B 35
  • 31 (a)
OneToOne
Species where no ortholog for CD8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD8B Gene

ENSEMBL:
Gene Tree for CD8B (if available)
TreeFam:
Gene Tree for CD8B (if available)

Paralogs for CD8B Gene

(3) SIMAP similar genes for CD8B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD8B Gene

genes like me logo Genes that share paralogs with CD8B: view

No data available for Paralogs for CD8B Gene

Variants for CD8B Gene

Sequence variations from dbSNP and Humsavar for CD8B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167692 -- 86,836,402(+) ATGTC(C/T)ATCCT intron-variant
rs10168023 -- 86,836,658(+) TGGTG(C/T)GCACC intron-variant
rs10189173 -- 86,844,228(+) CAGGC(G/T)CTTTC intron-variant
rs10200219 -- 86,844,351(+) CTGGT(A/G)GAAGA intron-variant
rs10204118 -- 86,838,400(+) TAGAA(G/T)ATGTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD8B Gene

Variant ID Type Subtype PubMed ID
dgv3886n100 CNV gain 25217958
dgv714e214 CNV gain 21293372
esv25494 CNV gain 19812545
esv3583914 CNV loss 25503493
esv3591559 CNV gain 21293372
nsv10063 CNV gain 18304495
nsv458585 CNV gain 19166990
nsv516466 CNV loss 19592680
nsv582373 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv961428 CNV duplication 23825009
nsv997982 CNV gain 25217958

Variation tolerance for CD8B Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8B Gene

Disorders for CD8B Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD8B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
immune system disease
  • immune system and disorders
mucinous stomach adenocarcinoma
  • mucinous adenocarcinoma of the stomach
- elite association - COSMIC cancer census association via MalaCards
Search CD8B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD8B

Genetic Association Database (GAD)
CD8B
Human Genome Epidemiology (HuGE) Navigator
CD8B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD8B
genes like me logo Genes that share disorders with CD8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD8B Gene

Publications for CD8B Gene

  1. Recent duplication of the two human CD8 beta-chain genes. (PMID: 1541829) Nakayama K. … Nakauchi H. (J. Immunol. 1992) 2 3 4 64
  2. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) HAPglinger G.U. … Schellenberg G.D. (Nat. Genet. 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PMID: 11937547) Kieffer L.J. … Kavathas P.B. (J. Immunol. 2002) 3 22 64
  5. Transcriptional diversity at the duplicated human CD8 beta loci. (PMID: 8436166) DiSanto J.P. … Flomenberg N. (Eur. J. Immunol. 1993) 3 4 64

Products for CD8B Gene

Sources for CD8B Gene

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