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CD8B Gene

protein-coding   GIFtS: 57
GCID: GC02M087042

CD8b Molecule

(Previous names: CD8 antigen, beta polypeptide 1 (p37))
(Previous symbol: CD8B1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD8b Molecule1 2     LYT32
CD8B11 2 3 5     P372
CD8 Antigen, Beta Polypeptide 1 (P37)1 2     T Lymphocyte Surface Glycoprotein Beta Chain2
LEU22     T-Cell Surface Glycoprotein CD8 Beta Chain2
LY32     CD8b Antigen3

External Ids:    HGNC: 17071   Entrez Gene: 9262   Ensembl: ENSG000001721167   OMIM: 1867305   UniProtKB: P109663   

Export aliases for CD8B gene to outside databases

Previous GC identifer: GC02M086895


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD8B Gene:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient
cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor
on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I
MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer
composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin
variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript
variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also
located on chromosome 2, has been identified. (provided by RefSeq, May 2010)

GeneCards Summary for CD8B Gene:
CD8B (CD8b molecule) is a protein-coding gene. Diseases associated with CD8B include mucinous stomach adenocarcinoma, and progressive supranuclear palsy. GO annotations related to this gene include MHC class I protein binding and coreceptor activity.

UniProtKB/Swiss-Prot: CD8B_HUMAN, P10966
Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought
to play a role in the process of T-cell mediated killing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD8B gene promoter:
         Nkx3-1 v4   AML1a   NF-AT   AREB6   NF-AT4   NF-AT2   Nkx3-1 v3   NF-AT3   ZIC2/Zic2   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CD8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p12

CD8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD8B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M087042:  view genomic region     (about GC identifiers)

Start:
87,042,460 bp from pter      End:
87,089,047 bp from pter
Size:
46,588 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD8B_HUMAN, P10966 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD8 beta chain precursor  
Size: 210 amino acids; 23722 Da
Subunit: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds
Sequence caution: Sequence=AAD13877.1; Type=Erroneous gene model prediction;
Secondary accessions: P14860 P14861 Q15980 Q496E0 Q496E1 Q496E2 Q9UDB4 Q9UDB5 Q9UDB6 Q9UDB7
Q9UDB8 Q9UDB9 Q9UDC0 Q9UQ55
Alternative splicing: 8 isoforms:  P10966-1   P10966-2   P10966-3   P10966-4   P10966-6   P10966-7   P10966-8   P10966-9   
(Ref.6 (AAI00915) sequence is in conflict in position: 213:I->V)

Explore the universe of human proteins at neXtProt for CD8B: NX_P10966

Explore proteomics data for CD8B at MOPED

Post-translational modifications: 

  • Phosphorylated as a consequence of T-cell activation (Potential)1
  • Glycosylation2 at Asn102

  • See CD8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171571.1  NP_004922.1  NP_742099.1  NP_742100.1  NP_757362.1  

    ENSEMBL proteins: 
     ENSP00000377356   ENSP00000340592   ENSP00000331172   ENSP00000375070   ENSP00000377358  
     ENSP00000394806  
    Reactome Protein details: P10966

    CD8B Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for CD8B
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    Browse Proteins at Cloud-Clone Corp.

    CD8B Antibody Products:

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    Browse R&D Systems for Antibodies
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    Abcam antibodies for CD8B (Q496E1, P04234, P10966)
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    CD8B Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P10966

    ProtoNet protein and cluster: P10966

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CD8B_HUMAN, P10966
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD8B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD8B_HUMAN, P10966
    Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought
    to play a role in the process of T-cell mediated killing

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI2493728
    GO:0015026coreceptor activity NAS11131152
    GO:0042288MHC class I protein binding NAS11131152
         
    CD8B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD8B:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd8b1):
     hematopoietic system  homeostasis/metabolism  immune system 

    CD8B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD8B: Cd8b1tm1Litt Cd8b1tm1Wpfl Cd8a/Cd8b1Cd8a/tm3Welm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD8B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD8B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD8B

    miRNA
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    hsa-miR-4291 hsa-miR-1286 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCD8B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CD8B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CD8B (see all 29)
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    GenScript: all cDNA clones in your preferred vector (see all 5): CD8B (NM_172213)
    Sino Biological Human cDNA Clone for CD8B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD8B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD8B_HUMAN, P10966: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable)
    CD8B_HUMAN, P10966: Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable)
    CD8B_HUMAN, P10966: Isoform 3: Secreted (Probable)
    CD8B_HUMAN, P10966: Isoform 4: Cell membrane; Single-pass type I membrane protein (Probable)
    CD8B_HUMAN, P10966: Isoform 5: Cell membrane; Single-pass type I membrane protein (Probable)
    CD8B_HUMAN, P10966: Isoform 6: Secreted (Probable)
    CD8B_HUMAN, P10966: Isoform 7: Secreted (Probable)
    CD8B_HUMAN, P10966: Isoform 8: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS3145195
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----

    CD8B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD8B About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
    Nef Mediated CD8 Down-regulation0.00
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    2HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    3CDK-mediated phosphorylation and removal of Cdc6
    Immune response Antigen presentation by MHC class I0.68
    4TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells0.64
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CD8B
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for CD8B
        Immune response Antigen presentation by MHC class I

    3 BioSystems Pathways for CD8B
        IL12-mediated signaling events
    TCR signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells


    2 Reactome Pathways for CD8B
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Nef Mediated CD8 Down-regulation


    5 Kegg Pathways  (Kegg details for CD8B):
        Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    T cell receptor signaling pathway
    Primary immunodeficiency


    CD8B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD8B: 
              Cell Surface Markers in human mouse rat
              Neurotoxicity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CD8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD8B (P109663 ENSP000003311724) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD247P209633, ENSP000003547824I2D: score=1 STRING: ENSP00000354782
    CD3DP042343, ENSP000003006924I2D: score=1 STRING: ENSP00000300692
    ST3GAL4Q112063, ENSP000002274954I2D: score=1 STRING: ENSP00000227495
    CD8AP017323, ENSP000002836354I2D: score=3 STRING: ENSP00000283635
    GRK5P349473I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS11131152
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS9830036
    GO:0016032viral process TAS--
    GO:0042110T cell activation NAS9830036
    GO:0050690regulation of defense response to virus by virus TAS--

    CD8B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD8B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD8B gene (6 alternative transcripts): 
    NM_001178100.1  NM_004931.4  NM_172101.3  NM_172102.3  NM_172213.3  NM_172099.2  

    Unigene Cluster for CD8B:

    CD8b molecule
    Hs.405667  [show with all ESTs]
    Unigene Representative Sequence: BX647150
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393759(uc002srx.3 uc002srw.3 uc002sry.3) ENST00000349455
    ENST00000331469 ENST00000390655(uc002srz.3 uc010yto.2) ENST00000393761(uc010fgt.3)
    ENST00000431506
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    hsa-miR-4291 hsa-miR-1286 hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCD8B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): CD8B (NM_172213)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD8B
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CD8B
      QuantiFast Probe-based Assays in human, mouse, rat CD8B

    Additional mRNA sequence: 

    AK303360.1 AK303595.1 BC100911.1 BC100912.2 BC100913.1 BC100914.1 BX647150.1 M36712.1 
    X13444.1 X13445.1 X13446.1 X13452.1 Y00805.1 

    13 DOTS entries:

    DT.454836  DT.91661340  DT.100022047  DT.95157768  DT.100754500  DT.100754501  DT.101959550  DT.40271550 
    DT.65287337  DT.40106278  DT.121025736  DT.121028764  DT.95298835 

    Selected AceView cDNA sequences (see all 54):

    NM_172099 NM_004931 AA293671 NM_172101 BV175346 NM_172213 Y00805 AW196661 
    NM_172100 AW504863 X13445 BQ004743 AW272094 BV180642 BV180614 AU185164 
    T28933 NM_172102 BX647150 AA725000 AW511492 AW083057 BV180597 BF507921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCTGAAA
    CD8B Expression
    About this image


    CD8B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T-Cytotoxic Cells Peripheral Blood
             Tumor infiltrating lymphocytes (C?ntego)
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CD8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405667

    UniProtKB/Swiss-Prot: CD8B_HUMAN, P10966
    Tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both
    thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral
    CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD8B: 
              Cell Surface Markers in human mouse rat
              Neurotoxicity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD8B
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    QuantiFast Probe-based Assays in human, mouse, rat CD8B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD8B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd8b11 , 5 CD8 antigen, beta chain 11, 5 70.69(n)1
    54.59(a)1
      6 (32.14 cM)5
    125261  NM_009858.21  NP_033988.11 
     713228125 
    chicken
    (Gallus gallus)
    Aves CD8B6
    T-cell surface glycoprotein CD8 beta chain precurs...
    31(a)
    1 ↔ 1
    4(85440288-85446044)


    ENSEMBL Gene Tree for CD8B (if available)
    TreeFam Gene Tree for CD8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD8B gene
    3 SIMAP similar genes for CD8B using alignment to 3 protein entries:     CD8B_HUMAN (see all proteins):
    CD8B1    CD81    CD8BP

    CD8B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD8B
    PGOHUM00000250471


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD8B (see all 853)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467951961,2
    Cuntested187085519(+) CTGGAA/G/TGACTG 10 L F mis10--------
    rs102059861,2
    C,F,H--86974818(-) CCATCC/GAGACC 4 -- us2k15Minor allele frequency- G:0.02NS EA NA 540
    rs558765191,2
    C,F--86974822(-) GTGTCC/TATCCA 4 -- us2k16Minor allele frequency- T:0.27NA CSA WA 245
    rs1408525821,2
    --86974864(-) TTTTTG/TAAAAA 4 -- us2k10--------
    rs1891125841,2
    --86974919(-) CTGGAA/CTGTAT 4 -- us2k10--------
    rs739522331,2
    C,F--86974926(-) AACACC/AACTGG 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1844990521,2
    --86974967(-) CTAGAC/TAGATG 4 -- us2k10--------
    rs43625551,2
    C,F,H--86975090(-) acaggG/Taaatc 4 -- us2k124Minor allele frequency- T:0.35NS EA NA WA CSA 2041
    rs1150593451,2
    F--87041974(+) AATAAA/TTTAAA 4 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1847088011,2
    --87041990(+) GCCGGG/TCCTGG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for CD8B (87042460 - 87089047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CD8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516466CNV Loss19592680
    esv25494CNV Gain19812545
    nsv458585CNV Gain19166990
    nsv874472CNV Gain21882294
    nsv10063CNV Gain18304495
    nsv874473CNV Gain21882294
    nsv7316OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186730    OMIM disorders: --

    9 diseases for CD8B:    
    About MalaCards
    mucinous stomach adenocarcinoma    progressive supranuclear palsy    tauopathy    hiv-1
    tonsillitis    adenocarcinoma    thyroiditis    cerebritis
    prostatitis


    CD8B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD8B
    Human Genome Epidemiology (HuGE) Navigator: CD8B (1 document)

    Export disorders for CD8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD8B gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with CD8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recent duplication of the two human CD8 beta-chain genes. (PubMed id 1541829)1, 2, 3 Nakayama K.... Nakauchi H. (J. Immunol. 1992)
    2. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PubMed id 21685912)1, 4 HAPglinger G.U....Schellenberg G.D. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Transcriptional diversity at the duplicated human CD8 beta loci. (PubMed id 8436166)1, 2 DiSanto J.P.... Flomenberg N. (Eur. J. Immunol. 1993)
    5. A second subunit of CD8 is expressed in human T cells. (PubMed id 3145195)1, 2 Norment A.M. and Littman D.R. (EMBO J. 1988)
    6. The human Lyt-3 molecule requires CD8 for cell surface expression. (PubMed id 3145196)1, 2 Disanto J.P.... Flomenberg N. (EMBO J. 1988)
    7. A second chain of human CD8 is expressed on peripheral blood lymphocytes. (PubMed id 3264320)1, 2 Shiue L.... Parnes J.R. (J. Exp. Med. 1988)
    8. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PubMed id 11937547)1, 9 Kieffer L.J.... Kavathas P.B. (J. Immunol. 2002)
    9. cAMP responsive element modulator (CREM) I+ mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. (PubMed id 24297179)1 Hedrich C.M....Tsokos G.C. (J. Biol. Chem. 2014)
    10. cAMP-responsive element modulator I+ (CREMI+) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. (PubMed id 24047902)1 Hedrich C.M....Tsokos G.C. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 926 HGNC: 1707 AceView: CD8B1 Ensembl:ENSG00000172116 euGenes: HUgn926
    ECgene: CD8B Kegg: 926 H-InvDB: CD8B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD8B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CD8

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD8B gene:
    Search GeneIP for patents involving CD8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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