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Aliases for CD8A Gene

Aliases for CD8A Gene

  • CD8a Molecule 2 3 5
  • T-Lymphocyte Differentiation Antigen T8/Leu-2 3 4
  • T-Cell Surface Glycoprotein CD8 Alpha Chain 2 3
  • CD8 Antigen, Alpha Polypeptide (P32) 2 3
  • MAL 3 4
  • Leu2 T-Lymphocyte Antigen 3
  • OKT8 T-Cell Antigen 3
  • T-Cell Antigen Leu2 3
  • T Cell Co-Receptor 3
  • T8 T-Cell Antigen 3
  • CD8a Antigen 4
  • Leu2 3
  • P32 3
  • CD8 3

External Ids for CD8A Gene

Previous HGNC Symbols for CD8A Gene

  • CD8

Previous GeneCards Identifiers for CD8A Gene

  • GC02M086907
  • GC02M087305
  • GC02M086986
  • GC02M086923
  • GC02M086865

Summaries for CD8A Gene

Entrez Gene Summary for CD8A Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CD8A Gene

CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Alveolar Echinococcosis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include protein homodimerization activity and coreceptor activity.

UniProtKB/Swiss-Prot for CD8A Gene

  • Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Gene Wiki entry for CD8A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD8A Gene

Genomics for CD8A Gene

Regulatory Elements for CD8A Gene

Enhancers for CD8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F086783 1.3 FANTOM5 Ensembl ENCODE 41.8 +19.0 18959 12.6 PKNOX1 ATF1 FEZF1 ZNF366 SCRT2 ZNF143 CREM JUNB REST TBX21 CD8A CD8B CHMP3 RNU6-640P REEP1 ENSG00000231259 RMND5A KDM3A RNF103 LOC105374846
GH02F086805 1.4 FANTOM5 Ensembl ENCODE 34.8 +0.5 543 5.3 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 GATA2 CD8A CD8B SNORD94 CHMP3 RNU6-640P REEP1 PLGLB1 LOC105374846
GH02F086764 0.6 ENCODE 7.7 +43.3 43318 0.8 CTCF ZNF654 USF2 TRIM22 EBF1 RAD21 RAD51 SMC3 PRDM1 CHMP3 RNU6-640P CD8A GC02M086689 LOC105374846
GH02F086747 0.4 ENCODE 7 +60.2 60222 1.5 BMI1 CEBPG IRF9 TRIM24 RFX1 ZNF740 HLF CEBPB EP300 POLR2H RNF103-CHMP3 RNF103 CHMP3 RNU6-640P CD8A RMND5A IMMT GC02M086689 LOC105374846
GH02F086732 0.2 Ensembl 6.1 +74.2 74196 4.4 ZNF133 CD8A POLR1A GC02M086689 RNF103-CHMP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD8A on UCSC Golden Path with GeneCards custom track

Promoters for CD8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001824726 395 1600 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 GATA2
ENSR00000122991 -704 200

Genomic Location for CD8A Gene

Chromosome:
2
Start:
86,784,605 bp from pter
End:
86,808,396 bp from pter
Size:
23,792 bases
Orientation:
Minus strand

Genomic View for CD8A Gene

Genes around CD8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8A Gene

Proteins for CD8A Gene

  • Protein details for CD8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01732-CD8A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 alpha chain
    Protein Accession:
    P01732
    Secondary Accessions:
    • B4DT80
    • D6W5M8
    • Q13970
    • Q4ZG17

    Protein attributes for CD8A Gene

    Size:
    235 amino acids
    Molecular mass:
    25729 Da
    Quaternary structure:
    • In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD8A Gene

    Alternative splice isoforms for CD8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD8A Gene

Post-translational modifications for CD8A Gene

  • All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD8A Gene

Antibody Products

No data available for DME Specific Peptides for CD8A Gene

Domains & Families for CD8A Gene

Gene Families for CD8A Gene

Graphical View of Domain Structure for InterPro Entry

P01732

UniProtKB/Swiss-Prot:

CD8A_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD8A: view

Function for CD8A Gene

Molecular function for CD8A Gene

GENATLAS Biochemistry:
cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes
UniProtKB/Swiss-Prot Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Gene Ontology (GO) - Molecular Function for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2470098
GO:0015026 coreceptor activity NAS 11131152
GO:0019901 protein kinase binding IEA --
GO:0042288 MHC class I protein binding NAS 11131152
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CD8A: view
genes like me logo Genes that share phenotypes with CD8A: view

Human Phenotype Ontology for CD8A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD8A Gene

MGI Knock Outs for CD8A:

Animal Model Products

miRNA for CD8A Gene

miRTarBase miRNAs that target CD8A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD8A Gene

Localization for CD8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8A Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD8A Gene COMPARTMENTS Subcellular localization image for CD8A gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
lysosome 2
mitochondrion 2
vacuole 2

Gene Ontology (GO) - Cellular Components for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane NAS 2496167
GO:0009897 external side of plasma membrane IEA,IDA 17213291
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CD8A: view

Pathways & Interactions for CD8A Gene

genes like me logo Genes that share pathways with CD8A: view

Interacting Proteins for CD8A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283635%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000332049%0d%0a9606.ENSP00000295756%0d%0a9606.ENSP00000431445%0d%0a9606.ENSP00000295743%0d%0a
Selected Interacting proteins: ENSP00000283635 P01732-CD8A_HUMAN for CD8A Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
B2M

Gene Ontology (GO) - Biological Process for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity IBA --
GO:0006955 immune response NAS 11131152
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 9830036
genes like me logo Genes that share ontologies with CD8A: view

No data available for SIGNOR curated interactions for CD8A Gene

Drugs & Compounds for CD8A Gene

(1) Drugs for CD8A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CD8A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD8A: view

Transcripts for CD8A Gene

Unigene Clusters for CD8A Gene

CD8a molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD8A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b
SP1:
SP2:
SP3: - -

Relevant External Links for CD8A Gene

GeneLoc Exon Structure for
CD8A
ECgene alternative splicing isoforms for
CD8A

Expression for CD8A Gene

mRNA expression in normal human tissues for CD8A Gene

mRNA differential expression in normal tissues according to GTEx for CD8A Gene

This gene is overexpressed in Whole Blood (x15.7) and Spleen (x14.7).

Protein differential expression in normal tissues from HIPED for CD8A Gene

This gene is overexpressed in Tlymphocyte (26.7) and CD8 Tcells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD8A Gene



Protein tissue co-expression partners for CD8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD8A Gene:

CD8A

SOURCE GeneReport for Unigene cluster for CD8A Gene:

Hs.85258
genes like me logo Genes that share expression patterns with CD8A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD8A Gene

Orthologs for CD8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD8A 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia CD8A 34 35
  • 79.22 (n)
cow
(Bos Taurus)
Mammalia CD8A 34 35
  • 74.06 (n)
rat
(Rattus norvegicus)
Mammalia Cd8a 34
  • 63.67 (n)
mouse
(Mus musculus)
Mammalia Cd8a 34 16 35
  • 63.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CD8A 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD8A 35
  • 30 (a)
OneToOne
Species where no ortholog for CD8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD8A Gene

ENSEMBL:
Gene Tree for CD8A (if available)
TreeFam:
Gene Tree for CD8A (if available)

Paralogs for CD8A Gene

genes like me logo Genes that share paralogs with CD8A: view

No data available for Paralogs for CD8A Gene

Variants for CD8A Gene

Sequence variations from dbSNP and Humsavar for CD8A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121918660 CD8 deficiency, familial (CD8 deficiency) [MIM:608957], Pathogenic 86,790,400(-) ACGAG(A/G)GCTAC nc-transcript-variant, reference, missense
rs1005834 -- 86,796,639(-) ATCAA(C/G)TCTAT intron-variant, nc-transcript-variant
rs10175902 -- 86,789,239(+) CTCCC(A/C/G)CCTCG intron-variant
rs10177148 -- 86,805,451(+) AGCTG(C/T)GGAGG intron-variant
rs10193355 -- 86,787,898(+) GAGAg(A/T)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD8A Gene

Variant ID Type Subtype PubMed ID
dgv3886n100 CNV gain 25217958
dgv714e214 CNV gain 21293372
esv25494 CNV gain 19812545
esv3591559 CNV gain 21293372
nsv10063 CNV gain 18304495
nsv458585 CNV gain 19166990
nsv477145 CNV novel sequence insertion 20440878
nsv582373 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv997982 CNV gain 25217958

Variation tolerance for CD8A Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD8A Gene

Human Gene Mutation Database (HGMD)
CD8A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8A Gene

Disorders for CD8A Gene

MalaCards: The human disease database

(113) MalaCards diseases for CD8A Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cd8 deficiency, familial
  • susceptibility to respiratory infections associated with cd8alpha chain mutation
alveolar echinococcosis
  • alveolococcosis
primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma
  • berti lymphoma
inflammatory linear verrucous epidermal nevus
  • ilven
diffuse infiltrative lymphocytosis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CD8A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD8A_HUMAN
  • CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269 PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD8A

Genetic Association Database (GAD)
CD8A
Human Genome Epidemiology (HuGE) Navigator
CD8A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD8A
genes like me logo Genes that share disorders with CD8A: view

No data available for Genatlas for CD8A Gene

Publications for CD8A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. (PMID: 14500983) Kim P.W. … Eck M.J. (Science 2003) 3 4 64
  3. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PMID: 11937547) Kieffer L.J. … Kavathas P.B. (J. Immunol. 2002) 3 22 64
  4. Familial CD8 deficiency due to a mutation in the CD8 alpha gene. (PMID: 11435463) de la Calle-Martin O. … Espanol T. (J. Clin. Invest. 2001) 3 4 64
  5. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PMID: 11140838) Comings D.E. … MacMurray J.P. (Clin. Genet. 2000) 3 46 64

Products for CD8A Gene

Sources for CD8A Gene

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