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CD8A Gene

protein-coding   GIFtS: 65
GCID: GC02M086923

CD8a Molecule

(Previous names: CD8 antigen, alpha polypeptide (p32), T-cell surface glycoprotein...)
(Previous symbol: CD8)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD8a Molecule1 2     Leu2 T-Lymphocyte Antigen2
CD81 2     OKT8 T-Cell Antigen2
CD8 Antigen, Alpha Polypeptide (P32)1 2     p322
T-Cell Surface Glycoprotein CD8 Alpha Chain1 2     T Cell Co-Receptor2
MAL2 3     T-Cell Antigen Leu22
T-Lymphocyte Differentiation Antigen T8/Leu-22 3     T8 T-Cell Antigen2
Leu22     CD8a Antigen3

External Ids:    HGNC: 17061   Entrez Gene: 9252   Ensembl: ENSG000001535637   OMIM: 1869105   UniProtKB: P017323   

Export aliases for CD8A gene to outside databases

Previous GC identifers: GC02M086907 GC02M087305 GC02M086986 GC02M086865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD8A Gene:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient
cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on
the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC
molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer
composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin
variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for CD8A Gene:
CD8A (CD8a molecule) is a protein-coding gene. Diseases associated with CD8A include cd8 deficiency, familial, and primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma. GO annotations related to this gene include protein homodimerization activity and coreceptor activity.

UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732
Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought
to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3
domains

Gene Wiki entry for CD8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD8A gene promoter:
         STAT1   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD8A promoter sequence
   Search Chromatin IP Primers for CD8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p12

CD8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD8A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M086923:  view genomic region     (about GC identifiers)

Start:
87,011,728 bp from pter      End:
87,035,519 bp from pter
Size:
23,792 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD8 alpha chain precursor  
Size: 235 amino acids; 25729 Da
Subunit: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form
homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood
T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner
5 PDB 3D structures from and Proteopedia for CD8A:
1AKJ (3D)        1CD8 (3D)        1Q69 (3D)        2HP4 (3D)        3QZW (3D)    
Secondary accessions: D6W5M8 Q13970 Q4ZG17
Alternative splicing: 2 isoforms:  P01732-1   P01732-2   

Explore the universe of human proteins at neXtProt for CD8A: NX_P01732

Explore proteomics data for CD8A at MOPED

Post-translational modifications: 

  • All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while
    the four N-terminal cysteines do not (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CD8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139345.1  NP_001759.3  NP_741969.1  

    ENSEMBL proteins: 
     ENSP00000321631   ENSP00000283635   ENSP00000386559   ENSP00000387314   ENSP00000438371  
     ENSP00000398868  
    Reactome Protein details: P01732

    CD8A Human Recombinant Protein Products:

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    Novus Biologicals CD8A Lysates
    Sino Biological Recombinant Protein for CD8A
    Sino Biological Cell Lysate for CD8A
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD8A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD8A
    R&D Systems Antibodies for CD8A (CD8)
    Cell Signaling Technology (CST) Antibodies for CD8A 
    OriGene Antibodies for CD8A
    OriGene Custom Antibody Services for CD8A
    Novus Biologicals CD8A Antibodies
    Abcam antibodies for CD8A (Q496E1, P01732, P04234, P10966, Q86X47)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CD8A
    LSBio Antibodies in human, mouse, rat for CD8A

    CD8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CD8A
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR015468 CD8_asu
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P01732

    ProtoNet protein and cluster: P01732

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD8A_HUMAN, P01732
    Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought
    to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3
    domains

         Genatlas biochemistry entry for CD8A:
    cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies
    T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI2470098
    GO:0015026coreceptor activity NAS11131152
    GO:0019901protein kinase binding IEA--
    GO:0042288MHC class I protein binding NAS11131152
    GO:0042803protein homodimerization activity IEA--
         
    CD8A for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 13 alleles(MGI details for Cd8a):
     hematopoietic system  immune system  integument  mortality/aging  nervous system 
     normal 

    CD8A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD8A: Cd8atm1Mak Cd8atm2Welm Cd8atm1.1Litt Cd8a/Cd8b1Cd8a/tm3Welm Cd8atm1.1Kio Cd8atm1Welm
                                                         Cd8atm1.1Welm Cd8atm2Kio Cd8atm1Litt Cd8atm2.1Welm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD8A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD8A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD8A

    miRNA
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    miRTarBase miRNAs that target CD8A:
    hsa-mir-335-5p (MIRT016928), hsa-mir-196b-5p (MIRT007284)

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    6 qRT-PCR Assays for microRNAs that regulate CD8A:
    hsa-miR-33a* hsa-miR-142-3p hsa-miR-4251 hsa-miR-1260b hsa-miR-1260 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCD8A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD8A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD8A (NM_001145873)
    Sino Biological Human cDNA Clone for CD8A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD8A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD8A_HUMAN, P01732: Isoform 1: Cell membrane; Single-pass type I membrane protein
    CD8A_HUMAN, P01732: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS2496167
    GO:0009897external side of plasma membrane IDA17213291
    GO:0009986cell surface ----

    CD8A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD8A About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    2TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    TCR Signaling0.68
    3CDK-mediated phosphorylation and removal of Cdc6
    Immune response Antigen presentation by MHC class I0.68
    4TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells0.64
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD8A
        CTLA4 Signaling
    PKC-Theta Pathway
    TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for CD8A
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for CD8A
        Immune response Antigen presentation by MHC class I

    4 BioSystems Pathways for CD8A
        TCR Signaling Pathway
    IL12-mediated signaling events
    TCR signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells


    1 Reactome Pathway for CD8A
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    5 Kegg Pathways  (Kegg details for CD8A):
        Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    T cell receptor signaling pathway
    Primary immunodeficiency


    CD8A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD8A (see all 10): 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD8A (P017323 ENSP000002836354) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235346P176933, ENSP000003973314I2D: score=3 STRING: ENSP00000397331
    HLA-GP176933, ENSP000003534724I2D: score=3 STRING: ENSP00000353472
    ENSG00000237216P176933, ENSP000004091324I2D: score=3 STRING: ENSP00000409132
    ENSG00000206506P176933I2D: score=3 
    ENSG00000230413P176933I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002456T cell mediated immunity IEA--
    GO:0006955immune response NAS11131152
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS9830036
    GO:0019882antigen processing and presentation NAS2496167

    CD8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD8A

    2 Novoseek inferred chemical compound relationships for CD8A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 47.5 4 11955389 (3), 14606076 (1)
    tyrosine 3.23 2 1902413 (2)



    CD8A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD8A gene (3 alternative transcripts): 
    NM_001145873.1  NM_001768.6  NM_171827.3  

    Unigene Cluster for CD8A:

    CD8a molecule
    Hs.85258  [show with all ESTs]
    Unigene Representative Sequence: NM_001145873
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352580 ENST00000283635(uc010ytn.2 uc002srt.3 uc002sru.3)
    ENST00000409511(uc002srv.3) ENST00000409781 ENST00000538832 ENST00000456996

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    6 qRT-PCR Assays for microRNAs that regulate CD8A:
    hsa-miR-33a* hsa-miR-142-3p hsa-miR-4251 hsa-miR-1260b hsa-miR-1260 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCD8A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD8A (NM_001145873)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CD8A
      QuantiFast Probe-based Assays in human, mouse, rat CD8A

    Additional mRNA sequence: 

    AK124156.1 AK300089.1 AY039664.1 BC025715.1 M12824.1 M12828.1 NR_027353.1 

    7 DOTS entries:

    DT.102838864  DT.100743986  DT.441450  DT.95325740  DT.121025834  DT.121025803  DT.75114423 

    Selected AceView cDNA sequences (see all 61):

    BM128838 M12828 AA854536 CB164560 BC025715 AI632645 AW452718 CR619549 
    AW949684 BI760884 AI452470 NM_171827 BI760947 NM_001768 BE646138 BI905877 
    AK124156 BI820267 AK097942 BM856680 BX415859 CB046018 BI835165 BI819839 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CD8A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                                                      
    SP2:                                                      
    SP3:                    -     -                           


    ECgene alternative splicing isoforms for CD8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATATGT
    CD8A Expression
    About this image


    CD8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 14 entries
             T-Cytotoxic Cells Peripheral Blood
             Tumor infiltrating lymphocytes (C?ntego)
     
     Thymus (Hematopoietic System)    fully expand to see all 7 entries
             Double Positive Thymocytes Thymus
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             Bone marrow-derived lineage-negative cells
     
     Heart (Cardiovascular System)
             Cardiac progenitor cells
    CD8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD8A (see all 10): 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD8A
    OriGene qSTAR qPCR primer pairs in human, mouse for CD8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD8A
    QuantiTect SYBR Green Assays in human, mouse, rat CD8A
    QuantiFast Probe-based Assays in human, mouse, rat CD8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CD8A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd8a1 , 5 CD8 antigen, alpha chain1, 5 63.33(n)1
    50.48(a)1
      6 (32.14 cM)5
    125251  NM_001081110.21  NP_001074579.11 
     713734275 
    lizard
    (Anolis carolinensis)
    Reptilia CD8A6
    CD8a molecule
    30(a)
    1 ↔ 1
    6(60462056-60479354)


    ENSEMBL Gene Tree for CD8A (if available)
    TreeFam Gene Tree for CD8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD8A gene
    13 SIMAP similar genes for CD8A using alignment to 5 protein entries:     CD8A_HUMAN (see all proteins):
    IGLV10-54    IGLV1-44    V1-17    V1-2    V1-4    IGLV2-18
    V2-13    IGLV1-40    IGLV2-11    V2-6    VL4    IGLV2-23
    V1-18

    CD8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD8A (see all 499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0210204
    CD8 deficiency, familial (CD8 deficiency)4--see VAR_0210202 G S mis40--------
    rs1443809431,2
    --86875318(+) TTTCCA/CTTCTC 4 -- int1 ds50010--------
    rs1817852691,2
    --86875333(+) AGTATC/TTTGGT 4 -- int1 ds50010--------
    rs1510692081,2
    --86875350(+) ACTAAC/TGACAG 4 -- int1 ds50010--------
    rs1158227551,2
    F--86875494(+) AGCATC/TGTCTC 4 -- int1 ds50011Minor allele frequency- T:0.01NA 120
    rs1409722591,2
    --86875890(+) ATTAAC/TAGGAG 4 -- ut31 nc-transcript-variant0--------
    rs1497742321,2
    --86875960(+) TCTCTC/TCAATG 4 -- ut31 nc-transcript-variant0--------
    rs67236811,2
    C,F--86876003(+) GGAAGT/AGCATG 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.09WA 118
    rs10513861,2
    C,F,A,H--86876085(-) GCCTCT/CGCTCA 4 -- ut31 nc-transcript-variantese321Minor allele frequency- C:0.20MN NS EA NA CSA WA 2522
    rs1865138461,2
    --86876096(+) CAGGGC/TTGTGT 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CD8A (87011728 - 87035519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25494CNV Gain19812545
    nsv458585CNV Gain19166990
    nsv874472CNV Gain21882294
    nsv10063CNV Gain18304495
    nsv7316OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): CD8A
    Locus Specific Mutation Databases (LSDB): CD8A

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CD8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186910   
    OMIM disorders: 608957  
    UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732
  • CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of
    CD8+ cells, leading to recurrent bacterial infections. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for CD8A (see all 83):    
    About MalaCards
    cd8 deficiency, familial    primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma    epidermal nevus    coccidiosis
    inflammatory linear verrucous epidermal nevus    pneumocystosis    lymphatic system disease    listeriosis
    alveolar echinococcosis    chickenpox    lichen sclerosus    borna disease
    intestinal obstruction    herpes zoster    primary immunodeficiency disease    vitiligo
    echinococcosis    breast cyst    lymphocytic choriomeningitis    lymphoblastic lymphoma


    CD8A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    8 Novoseek inferred disease relationships for CD8A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitiligo 44 3 1587659 (1), 7871844 (1)
    lymphoma t-cell 39.9 1 1672730 (1)
    tumors 14 5 14626186 (1), 9820863 (1), 10434348 (1), 11014542 (1) (see all 5)
    acute leukemia 11.5 2 12764905 (1), 15892271 (1)
    dermatitis atopic 9.93 1 8775293 (1)
    necrosis 6.4 3 14626186 (1), 19659765 (1), 12764905 (1)
    inflammation 0 1 10587516 (1)
    melanoma 0 1 9651826 (1)

    Genetic Association Database (GAD): CD8A
    Human Genome Epidemiology (HuGE) Navigator: CD8A (2 documents)

    Export disorders for CD8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD8A gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with CD8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. (PubMed id 14500983)1, 2 Kim P.W.... Eck M.J. (Science 2003)
    2. Familial CD8 deficiency due to a mutation in the CD8 alpha gene. (PubMed id 11435463)1, 2 de la Calle-Martin O.... Espanol T. (J. Clin. Invest. 2001)
    3. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)1, 4 Comings D.E....MacMurray J.P. (Clin. Genet. 2000)
    4. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. (PubMed id 9177355)1, 2 Gao G.F.... Jakobsen B.K. (Nature 1997)
    5. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution. (PubMed id 1547508)1, 2 Leahy D.J.... Hendrickson W.A. (Cell 1992)
    6. Recent duplication of the two human CD8 beta-chain genes. (PubMed id 1541829)1, 3 Nakayama K.... Nakauchi H. (J. Immunol. 1992)
    7. Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene. (PubMed id 2496167)1, 2 Norment A.M.... Littman D.R. (J. Immunol. 1989)
    8. A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing. (PubMed id 2536941)1, 2 Giblin P.... Kavathas P. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    9. Structure and expression of the gene encoding CD8 alpha chain (Leu- 2/T8). (PubMed id 2509342)1, 2 Nakayama K.... Nakauchi H. (Immunogenetics 1989)
    10. The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. (PubMed id 3918796)1, 2 Sukhatme V.P.... Parnes J.R. (Cell 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 925 HGNC: 1706 AceView: CD8A Ensembl:ENSG00000153563 euGenes: HUgn925
    ECgene: CD8A Kegg: 925 H-InvDB: CD8A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD8A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD8A Genetics and Cytogenetics in Oncology and Haematology
    CD8Abasehttp://bioinf.uta.fi/CD8Abase/
    Wikipedia http://en.wikipedia.org/wiki/CD8

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD8A gene:
    Search GeneIP for patents involving CD8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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