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Aliases for CD8A Gene

Aliases for CD8A Gene

  • CD8a Molecule 2 3
  • T-Lymphocyte Differentiation Antigen T8/Leu-2 3 4
  • T-Cell Surface Glycoprotein CD8 Alpha Chain 2 3
  • CD8 Antigen, Alpha Polypeptide (P32) 2 3
  • MAL 3 4
  • Leu2 T-Lymphocyte Antigen 3
  • OKT8 T-Cell Antigen 3
  • T-Cell Antigen Leu2 3
  • T Cell Co-Receptor 3
  • T8 T-Cell Antigen 3
  • CD8a Antigen 4
  • Leu2 3
  • P32 3
  • CD8 3

External Ids for CD8A Gene

Previous HGNC Symbols for CD8A Gene

  • CD8

Previous GeneCards Identifiers for CD8A Gene

  • GC02M086907
  • GC02M087305
  • GC02M086986
  • GC02M086923
  • GC02M086865

Summaries for CD8A Gene

Entrez Gene Summary for CD8A Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CD8A Gene

CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include cd8 deficiency, familial and susceptibility to respiratory infections associated with cd8alpha chain mutation. Among its related pathways are Class I MHC mediated antigen processing and presentation and TCR Signaling (Qiagen). GO annotations related to this gene include protein homodimerization activity and coreceptor activity.

UniProtKB/Swiss-Prot for CD8A Gene

  • Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains

Gene Wiki entry for CD8A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD8A Gene

Genomics for CD8A Gene

Regulatory Elements for CD8A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD8A Gene

Start:
86,784,605 bp from pter
End:
86,808,396 bp from pter
Size:
23,792 bases
Orientation:
Minus strand

Genomic View for CD8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8A Gene

Proteins for CD8A Gene

  • Protein details for CD8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01732-CD8A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 alpha chain
    Protein Accession:
    P01732
    Secondary Accessions:
    • B4DT80
    • D6W5M8
    • Q13970
    • Q4ZG17

    Protein attributes for CD8A Gene

    Size:
    235 amino acids
    Molecular mass:
    25729 Da
    Quaternary structure:
    • In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD8A Gene

    Alternative splice isoforms for CD8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD8A Gene

Proteomics data for CD8A Gene at MOPED

Post-translational modifications for CD8A Gene

  • All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD8A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD8A Gene

Domains for CD8A Gene

Gene Families for CD8A Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD8A Gene

Graphical View of Domain Structure for InterPro Entry

P01732

UniProtKB/Swiss-Prot:

CD8A_HUMAN :
  • P01732
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD8A: view

Function for CD8A Gene

Molecular function for CD8A Gene

GENATLAS Biochemistry: cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes
UniProtKB/Swiss-Prot Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains

Gene Ontology (GO) - Molecular Function for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2470098
GO:0015026 coreceptor activity NAS 11131152
GO:0019901 protein kinase binding IEA --
GO:0042288 MHC class I protein binding NAS 11131152
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CD8A: view
genes like me logo Genes that share phenotypes with CD8A: view

Animal Models for CD8A Gene

MGI Knock Outs for CD8A:

Animal Model Products

CRISPR Products

miRNA for CD8A Gene

miRTarBase miRNAs that target CD8A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD8A Gene

Localization for CD8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8A Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD8A Gene COMPARTMENTS Subcellular localization image for CD8A gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2496167
GO:0009897 external side of plasma membrane IDA 17213291
GO:0009986 cell surface --
genes like me logo Genes that share ontologies with CD8A: view

Pathways for CD8A Gene

genes like me logo Genes that share pathways with CD8A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity IEA --
GO:0006955 immune response NAS 11131152
GO:0007166 cell surface receptor signaling pathway --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 9830036
GO:0019882 antigen processing and presentation NAS 2496167
genes like me logo Genes that share ontologies with CD8A: view

Compounds for CD8A Gene

(2) Novoseek inferred chemical compound relationships for CD8A Gene

Compound -log(P) Hits PubMed IDs
il 10 47.5 4
tyrosine 3.23 2
genes like me logo Genes that share compounds with CD8A: view

Transcripts for CD8A Gene

Unigene Clusters for CD8A Gene

CD8a molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD8A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD8A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b
SP1:
SP2:
SP3: - -

Relevant External Links for CD8A Gene

GeneLoc Exon Structure for
CD8A
ECgene alternative splicing isoforms for
CD8A

Expression for CD8A Gene

mRNA expression in normal human tissues for CD8A Gene

mRNA differential expression in normal tissues according to GTEx for CD8A Gene

This gene is overexpressed in Whole Blood (15.7) and Spleen (14.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD8A Gene

SOURCE GeneReport for Unigene cluster for CD8A Gene Hs.85258

genes like me logo Genes that share expressions with CD8A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD8A Gene

Orthologs for CD8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD8A 35
  • 99.29 (n)
  • 99.15 (a)
CD8A 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD8A 35
  • 74.06 (n)
  • 62.74 (a)
CD8A 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD8A 35
  • 79.22 (n)
  • 68.84 (a)
CD8A 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd8a 35
  • 63.33 (n)
  • 50.48 (a)
Cd8a 16
Cd8a 36
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD8A 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd8a 35
  • 63.67 (n)
  • 51.5 (a)
lizard
(Anolis carolinensis)
Reptilia CD8A 36
  • 30 (a)
OneToOne
Species with no ortholog for CD8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD8A Gene

ENSEMBL:
Gene Tree for CD8A (if available)
TreeFam:
Gene Tree for CD8A (if available)

Paralogs for CD8A Gene

Selected SIMAP similar genes for CD8A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CD8A: view

No data available for Paralogs for CD8A Gene

Variants for CD8A Gene

Sequence variations from dbSNP and Humsavar for CD8A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1005834 -- 86,796,639(-) ATCAA(C/G)TCTAT intron-variant
rs1051386 -- 86,784,950(-) GCCTC(C/T)GCTCA utr-variant-3-prime, nc-transcript-variant
rs1515950 -- 86,793,694(-) CCTCA(A/G)TGCTT intron-variant, upstream-variant-2KB
rs2015234 -- 86,802,277(+) tagta(A/T)tctgc intron-variant
rs2229239 -- 86,790,539(-) GCCGC(A/C)GCCAG synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CD8A Gene

Variant ID Type Subtype PubMed ID
nsv10063 CNV Gain 18304495
nsv874472 CNV Gain 21882294
esv25494 CNV Gain 19812545
nsv458585 CNV Gain 19166990
nsv7316 OTHER Inversion 18451855

Relevant External Links for CD8A Gene

HapMap Linkage Disequilibrium report
CD8A
Human Gene Mutation Database (HGMD)
CD8A
Locus Specific Mutation Databases (LSDB)
CD8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8A Gene

Disorders for CD8A Gene

(1) OMIM Diseases for CD8A Gene (186910)

UniProtKB/Swiss-Prot

CD8A_HUMAN
  • CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269 PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for CD8A Gene

Disease -log(P) Hits PubMed IDs
vitiligo 44 2
lymphoma t-cell 39.9 1
tumors 14 5
acute leukemia 11.5 2
dermatitis atopic 9.93 1

Relevant External Links for CD8A

Genetic Association Database (GAD)
CD8A
Human Genome Epidemiology (HuGE) Navigator
CD8A
genes like me logo Genes that share disorders with CD8A: view

Publications for CD8A Gene

  1. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PMID: 11937547) Kieffer L.J. … Kavathas P.B. (J. Immunol. 2002) 3 23
  2. Recent duplication of the two human CD8 beta-chain genes. (PMID: 1541829) Nakayama K. … Nakauchi H. (J. Immunol. 1992) 2 3
  3. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution. (PMID: 1547508) Leahy D.J. … Hendrickson W.A. (Cell 1992) 3 4
  4. Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene. (PMID: 2496167) Norment A.M. … Littman D.R. (J. Immunol. 1989) 3 4
  5. Structure and expression of the gene encoding CD8 alpha chain (Leu- 2/T8). (PMID: 2509342) Nakayama K. … Nakauchi H. (Immunogenetics 1989) 3 4

Products for CD8A Gene

Sources for CD8A Gene

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