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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD8A Gene

protein-coding GIFtS: 66
GCID: GC02M086923

CD8a molecule

(Previous names: CD8 antigen, alpha polypeptide (p32), T-cell surface glycoprotein...)
(Previous symbol: CD8)

Explore 78 diseases affiliated with
CD8A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD8a Molecule¹ ²		Leu2 T-Lymphocyte Antigen²
CD8¹ ²		OKT8 T-Cell Antigen²
CD8 Antigen, Alpha Polypeptide (P32)¹ ²		P32¹
T-Cell Surface Glycoprotein CD8 Alpha Chain¹ ²		T Cell Co-Receptor²
MAL² ³		T-Cell Antigen Leu2²
T-Lymphocyte Differentiation Antigen T8/Leu-2² ³		T8 T-Cell Antigen²
Leu2²		CD8a Antigen³

External Ids:	HGNC: 1706¹	Entrez Gene: 925²	Ensembl: ENSG00000153563⁷	OMIM: 186910⁵	UniProtKB: P01732³

Export aliases for CD8A gene to outside databases

Previous GC identifers: GC02M086907 GC02M087305 GC02M086986 GC02M086865

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD8A:

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell

interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T

lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The

coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and

one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This

gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732

Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to

play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains

Gene Wiki entry for CD8A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD8A gene promoter:
STAT1 p53 AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD8A promoter sequence

Search SABiosciences Chromatin IP Primers for CD8A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD8A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p12

CD8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD8A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M086923: view genomic region (about GC identifiers)

Start:	87,011,728 bp from pter	End:	87,035,519 bp from pter
Size:	23,792 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732 (See protein sequence)

Recommended Name: T-cell surface glycoprotein CD8 alpha chain precursor

Size: 235 amino acids; 25729 Da

Subunit: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.

Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with

the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

5 PDB 3D structures from and Proteopedia for CD8A:

1AKJ (3D)

1CD8 (3D)

1Q69 (3D)

2HP4 (3D)

3QZW (3D)

Secondary accessions: D6W5M8 Q13970 Q4ZG17

Alternative splicing: 2 isoforms: P01732-1 P01732-2

Explore the universe of human proteins at neXtProt for CD8A: NX_P01732

Post-translational modifications:

All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the

four N-terminal cysteines do not (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01732

CD8A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001139345.1 NP_001759.3 NP_741969.1

ENSEMBL proteins:

ENSP00000321631 ENSP00000283635 ENSP00000386559 ENSP00000387314 ENSP00000438371

ENSP00000398868

Reactome Protein details: P01732
Human Recombinant Protein Products for CD8A:

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	Sino Biological Recombinant Protein for CD8A
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	Uscn Proteins for CD8A

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	2496167
GO:0009897	external side of plasma membrane	IDA	17213291
GO:0009986	cell surface	--	--

CD8A for ontologies About GeneDecksing

CD8A Antibody Products:

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	Novus Biologicals CD8A Antibodies
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	ThermoFisher Antibody for CD8A

Assay Products for CD8A:

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	GenScript Custom Assay Services for CD8A
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	Uscn ELISAs and CLIAs for CD8A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD8A for domains About GeneDecksing

5 InterPro domains/families:

IPR003596 Ig_V-set_subgr

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR015468 CD8_asu

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P01732

ProtoNet protein and cluster: P01732

2 Blocks protein families:

IPB003596 Immunoglobulin V-type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD8A_HUMAN, P01732

Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to

play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains

Genatlas biochemistry entry for CD8A:

cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies

T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	2470098
GO:0015026	coreceptor activity	NAS	11131152
GO:0019901	protein kinase binding	IEA	--
GO:0042288	MHC class I protein binding	NAS	11131152
GO:0042803	protein homodimerization activity	IEA	--

CD8A for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Cd8a):

cellular	hematopoietic system	immune system	integument	mortality/aging
nervous system	normal

CD8A for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-outs for CD8A: Cd8a^tm1Mak Cd8a^tm2Welm Cd8a^tm1.1Litt Cd8a/Cd8b1^Cd8a/tm3Welm Cd8a^tm1.1Kio Cd8a^tm1Welm
                                               Cd8a^tm1.1Welm Cd8a^tm2Kio Cd8a^tm1Litt Cd8a^tm2.1Welm

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD8A

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD8A:
		hsa-miR-33a* hsa-miR-142-3p hsa-miR-4251 hsa-miR-1260b hsa-miR-1260 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: CD8A 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Immune response Antigen presentation by MHC class I

Immune response Antigen presentation by MHC class I

1.00

Immune response_Antigen presentation by MHC class I

0.92

PKC-Theta Pathway

PKC-Theta Pathway

1.00

TCR Signaling

0.68

B cell receptor signaling pathway

T cell receptor signaling pathway

0.40

TCR Signaling Pathway

0.19

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CD8A

Immune response Antigen presentation by MHC class I

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD8A

	CTLA4 Signaling
	PKC-Theta Pathway
	TCR Signaling

1 Cell Signaling Technology (CST) Pathway for CD8A

Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for CD8A

Immune response Antigen presentation by MHC class I

4 BioSystems Pathways for CD8A

	TCR Signaling Pathway
	TCR signaling in naive CD8+ T cells
	IL12-mediated signaling events
	Downstream signaling in naive CD8+ T cells

3 Reactome Pathways for CD8A

	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Immune System

5 Kegg Pathways (Kegg details for CD8A):

	Cell adhesion molecules (CAMs)
	Antigen processing and presentation
	Hematopoietic cell lineage
	T cell receptor signaling pathway
	Primary immunodeficiency

CD8A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD8A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for CD8A (P01732³ ENSP00000283635⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HLA-A	P30443³, ENSP00000366005⁴	I2D: score=2 I2D: score=1 STRING: ENSP00000366005
B2M	P61769³, ENSP00000340858⁴	I2D: score=3 STRING: ENSP00000340858
CD3D	P04234³, ENSP00000300692⁴	I2D: score=3 STRING: ENSP00000300692
LCK	P06239³, ENSP00000337825⁴	I2D: score=3 STRING: ENSP00000337825
PTPRC	P08575³, ENSP00000356346⁴	I2D: score=3 STRING: ENSP00000356346

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002456	T cell mediated immunity	IEA	--
GO:0006955	immune response	NAS	11131152
GO:0007166	cell surface receptor signaling pathway	--	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS	9830036
GO:0019882	antigen processing and presentation	NAS	2496167

CD8A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD8A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD8A
2 Novoseek chemical compound relationships for CD8A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il 10	47.5	4	11955389 (3), 14606076 (1)
tyrosine	3.23	2	1902413 (2)

Search CenterWatch for drugs/clinical trials and news about CD8A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD8A gene (3 alternative transcripts):

NM_001145873.1 NM_001768.6 NM_171827.3

Unigene Cluster for CD8A:

CD8a molecule

Hs.85258 [show with all ESTs]

Unigene Representative Sequence: NM_001145873

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000352580 ENST00000283635(uc010ytn.2 uc002srt.3 uc002sru.3)

ENST00000409511(uc002srv.3) ENST00000409781 ENST00000538832 ENST00000456996

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD8A:
		hsa-miR-33a* hsa-miR-142-3p hsa-miR-4251 hsa-miR-1260b hsa-miR-1260 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: CD8A 3' UTR sequence

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Additional cDNA sequence:

AK124156.1 AK300089.1 AY039664.1 BC025715.1 M12824.1 M12828.1 NR_027353.1

7 DOTS entries:

DT.102838864 DT.100743986 DT.441450 DT.95325740 DT.121025834 DT.121025803 DT.75114423

24/61 AceView cDNA sequences (see all 61):

AA854536 CR619549 M12828 AI452470 BI760947 BC025715 NM_001768 AW452718

AI632645 BM128838 CB164560 BI760884 AW949684 NM_171827 BI820267 BI905877

BX327291 AK124156 BX415859 BI835165 AI992204 AL552456 BI819839 AA443584

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CD8A About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b
SP1:
SP2:
SP3:							-		-

ECgene alternative splicing isoforms for CD8A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD8A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAATATGT

About this image

CD8A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD8A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD8A

SOURCE GeneReport for Unigene cluster: Hs.85258

SABiosciences Expression via Pathway-Focused PCR Arrays including CD8A (see all 10):

Cell Surface Markers in human mouse rat

Lymphoma in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Stem Cells in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD8A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD8A gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd8a^{1 , 5}	CD8 antigen, alpha chain^{1, 5}	63.74(n)¹ 53.07(a)¹		6 (32.14 cM)⁵ 12525¹ NM_001081110.2¹ NP_001074579.1¹ 71373427⁵
chicken (Gallus gallus)	Aves	CD8A¹	CD8a molecule	49.69(n) 37.04(a)		403158 NM_205235.1 NP_990566.1

ENSEMBL Gene Tree for CD8A (if available)
TreeFam Gene Tree for CD8A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6723681^1,2	C,F	--	86898263(+)	`GGAAGT/AGCATG`	4	--	ut3¹ nc-transcript-variant		1	WA	118
rs7563485^1,2	C,F,A,H	--	86898980(+)	`TAAAAC/TGGGCG`	4	--	ut3¹ nc-transcript-variantese³		10	NS NA WA	1532
rs7563771^1,2	C,F	--	86899114(+)	`CCCTTG/ATGGTG`	4	--	ut3¹ nc-transcript-variantese³		1	WA	118
rs73947267^1,2	C	--	86899865(+)	`AAACAC/TGCTAA`	4	--	int¹		1	WA	2
rs3020728^1,2	C,F	--	86900045(-)	`TCATTT/GTGAGA`	4	--	int¹		6	NA CSA EA	248
rs75682489^1,2	C	--	86900149(+)	`GCGGTG/AGCTCA`	4	--	int¹		1	WA	2
rs111976570^1,2	C	--	86900386(+)	`CACTCC/AAGCCT`	4	--	int¹		2	NA CSA	3
rs62146062^1,2		--	86900687(+)	`TGTAAC/GATATG`	4	--	int¹		3	NA WA	240
rs56061957^1,2		--	86901058(+)	`CGTGCG/ATTGTA`	4	--	int¹		3	NA WA	240
rs34229949^1,2	F	--	86901553(+)	`GTTTTC/TTTAAG`	4	--	int¹		1	NA	4

HapMap Linkage Disequilibrium report for CD8A (87011728 - 87035519 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CD8A
2 CNVs: 30957 68073
Human Gene Mutation Database (HGMD): CD8A

Locus Specific Mutation Databases (LSDB): CD8A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD8A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD8A for disorders           About GeneDecksing

OMIM gene information: 186910
OMIM disorders: 608957
UniProtKB/Swiss-Prot: CD8A_HUMAN, P01732

Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency

is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent

bacterial infections

20/78 diseases for CD8A (see all 78): About MalaCards

inflammatory linear verrucous epidermal nevus vogt-koyanagi-harada disease epidermal nevus hypersensitivity reaction type ii disease

tropical spastic paraparesis human immunodeficiency virus infectious disease spastic paraparesis alveolar echinococcosis

non-hodgkin lymphoma lichen sclerosus xeroderma pigmentosum wegener's granulomatosis

infectious mononucleosis lymphatic system disease herpes zoster lymphocytic choriomeningitis

nevus echinococcosis coccidiosis pneumocystosis

8 Novoseek disease relationships for CD8A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitiligo	44	3	1587659 (1), 7871844 (1)
lymphoma t-cell	39.9	1	1672730 (1)
tumors	14	5	14626186 (1), 9820863 (1), 10434348 (1), 11014542 (1) (see all 5)
acute leukemia	11.5	2	12764905 (1), 15892271 (1)
dermatitis atopic	9.93	1	8775293 (1)
necrosis	6.4	3	14626186 (1), 19659765 (1), 12764905 (1)
inflammation	0	1	10587516 (1)
melanoma	0	1	9651826 (1)

Human Genome Epidemiology (HuGE) Navigator: CD8A (2 documents)

Export disorders for CD8A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD8A gene, integrated from 9 sources (see all 188):
(articles sorted by number of sources associating them with CD8A)

Utopia: connect your pdf to the dynamic
world of online information

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. (PubMed id 14500983)^{1, 2} Kim P.W.... Eck M.J. (2003)
Familial CD8 deficiency due to a mutation in the CD8 alpha gene. (PubMed id 11435463)^{1, 2} de la Calle-Martin O.... Espanol T. (2001)
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. (PubMed id 9177355)^{1, 2} Gao G.F.... Jakobsen B.K. (1997)
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution. (PubMed id 1547508)^{1, 2} Leahy D.J.... Hendrickson W.A. (1992)
Recent duplication of the two human CD8 beta-chain genes. (PubMed id 1541829)^{1, 3} Nakayama K.... Nakauchi H. (1992)
Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene. (PubMed id 2496167)^{1, 2} Norment A.M.... Littman D.R. (1989)
A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing. (PubMed id 2536941)^{1, 2} Giblin P.... Kavathas P. (1989)
Structure and expression of the gene encoding CD8 alpha chain (Leu- 2/T8). (PubMed id 2509342)^{1, 2} Nakayama K.... Nakauchi H. (1989)
The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. (PubMed id 3918796)^{1, 2} Sukhatme V.P.... Parnes J.R. (1985)
Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone. (PubMed id 3936473)^{1, 2} Parnes J.R.... Hunkapiller T. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 925	HGNC: 1706	AceView: CD8A	Ensembl:ENSG00000153563	euGenes: HUgn925
ECgene: CD8A	Kegg: 925	H-InvDB: CD8A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD8A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD8A	Genetics and Cytogenetics in Oncology and Haematology
CD8Abase	http://bioinf.uta.fi/CD8Abase/
Wikipedia	http://en.wikipedia.org/wiki/CD8

Intellectual Property for CD8A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD8A gene:
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GeneCards and IP:
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About This Section

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