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Aliases for CD86 Gene

Aliases for CD86 Gene

  • CD86 Molecule 2 3 5
  • CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen) 2 3
  • CTLA-4 Counter-Receptor B7.2 3 4
  • CD28LG2 3 4
  • FUN-1 3 4
  • BU63 3 4
  • B70 3 4
  • B-Lymphocyte Activation Antigen B7-2 3
  • B-Lymphocyte Antigen B7-2 2
  • Activation B7-2 Antigen 4
  • CD86 Antigen 4
  • LAB72 3
  • B7-2 3
  • B7.2 3

External Ids for CD86 Gene

Previous HGNC Symbols for CD86 Gene

  • CD28LG2

Previous GeneCards Identifiers for CD86 Gene

  • GC03P118451
  • GC03P121633
  • GC03P123055
  • GC03P123095
  • GC03P123256
  • GC03P121774
  • GC03P119148

Summaries for CD86 Gene

Entrez Gene Summary for CD86 Gene

  • This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

GeneCards Summary for CD86 Gene

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include lymphohistiocytoid mesothelioma and autoimmune disease of central nervous system. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include receptor binding and coreceptor activity. An important paralog of this gene is CD80.

UniProtKB/Swiss-Prot for CD86 Gene

  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD86 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD86 Gene

Genomics for CD86 Gene

Regulatory Elements for CD86 Gene

Promoters for CD86 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD86 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD86 gene promoter:

Genomic Location for CD86 Gene

Chromosome:
3
Start:
122,055,362 bp from pter
End:
122,121,143 bp from pter
Size:
65,782 bases
Orientation:
Plus strand

Genomic View for CD86 Gene

Genes around CD86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD86 Gene

Proteins for CD86 Gene

  • Protein details for CD86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42081-CD86_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD86
    Protein Accession:
    P42081
    Secondary Accessions:
    • A0N0P0
    • B7Z2F3
    • B7Z702
    • E7ETN5
    • E9PC27
    • Q13655
    • Q6FHB1
    • Q6GTS4
    • Q7M4L5

    Protein attributes for CD86 Gene

    Size:
    329 amino acids
    Molecular mass:
    37682 Da
    Quaternary structure:
    • Homodimer. Interacts with MARCH8.
    • (Microbial infection) Interacts with adenovirus subgroup b fiber protein.

    Three dimensional structures from OCA and Proteopedia for CD86 Gene

    Alternative splice isoforms for CD86 Gene

neXtProt entry for CD86 Gene

Proteomics data for CD86 Gene at MOPED

Post-translational modifications for CD86 Gene

  • Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
  • Glycosylation at Asn 33, Asn 47, Asn 135, Asn 146, Asn 154, Asn 177, Asn 192, and Asn 213
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD86 Gene

Domains & Families for CD86 Gene

Protein Domains for CD86 Gene

Suggested Antigen Peptide Sequences for CD86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42081

UniProtKB/Swiss-Prot:

CD86_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD86: view

Function for CD86 Gene

Molecular function for CD86 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on monocytes,dendritic cells and activated B,T and natural killer cells (antigen presenting cells)
UniProtKB/Swiss-Prot Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Ontology (GO) - Molecular Function for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with CD86: view
genes like me logo Genes that share phenotypes with CD86: view

Animal Models for CD86 Gene

MGI Knock Outs for CD86:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD86 Gene

Localization for CD86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD86 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD86 Gene COMPARTMENTS Subcellular localization image for CD86 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
endosome 2
lysosome 2
nucleus 2
vacuole 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CD86 Gene

Pathways & Interactions for CD86 Gene

SuperPathways for CD86 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 Allograft rejection
4 CD28 co-stimulation
5 Immune System
genes like me logo Genes that share pathways with CD86: view

Gene Ontology (GO) - Biological Process for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway IEA --
GO:0002309 T cell proliferation involved in immune response IEA --
GO:0002668 negative regulation of T cell anergy IEA --
GO:0006955 immune response TAS 7694363
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CD86: view

No data available for SIGNOR curated interactions for CD86 Gene

Drugs & Compounds for CD86 Gene

(15) Drugs for CD86 Gene - From: Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma binder, Target, antagonist 139
Antithymocyte globulin Approved Pharma binder, Target 0
Belatacept Approved Pharma inhibitor, Target 0
ASP2408 Pharma 0
RG-2077 Pharma 0

(12) Additional Compounds for CD86 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD86: view

Transcripts for CD86 Gene

Unigene Clusters for CD86 Gene

CD86 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD86 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for CD86 Gene

GeneLoc Exon Structure for
CD86
ECgene alternative splicing isoforms for
CD86

Expression for CD86 Gene

mRNA expression in normal human tissues for CD86 Gene

mRNA differential expression in normal tissues according to GTEx for CD86 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for CD86 Gene

This gene is overexpressed in Heart (31.5), Monocytes (26.3), and Retina (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD86 Gene



SOURCE GeneReport for Unigene cluster for CD86 Gene Hs.171182

mRNA Expression by UniProt/SwissProt for CD86 Gene

P42081-CD86_HUMAN
Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
genes like me logo Genes that share expression patterns with CD86: view

Protein tissue co-expression partners for CD86 Gene

Primer Products

In Situ Assay Products

Orthologs for CD86 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD86 36
  • 99 (a)
OneToOne
CD86 35
  • 99.59 (n)
  • 99.09 (a)
cow
(Bos Taurus)
Mammalia CD86 36
  • 54 (a)
OneToOne
CD86 35
  • 74.38 (n)
  • 58.02 (a)
dog
(Canis familiaris)
Mammalia CD86 35
  • 78.84 (n)
  • 63.47 (a)
CD86 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd86 16
Cd86 36
  • 47 (a)
OneToOne
Cd86 35
  • 68.37 (n)
  • 52.38 (a)
oppossum
(Monodelphis domestica)
Mammalia CD86 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD86 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd86 35
  • 68.86 (n)
  • 55.43 (a)
chicken
(Gallus gallus)
Aves CD86 35
  • 51.17 (n)
  • 36.33 (a)
CD86 36
  • 31 (a)
OneToOne
Species with no ortholog for CD86:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD86 Gene

ENSEMBL:
Gene Tree for CD86 (if available)
TreeFam:
Gene Tree for CD86 (if available)

Paralogs for CD86 Gene

Paralogs for CD86 Gene

genes like me logo Genes that share paralogs with CD86: view

Variants for CD86 Gene

Sequence variations from dbSNP and Humsavar for CD86 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1129055 - 122,119,472(+) ATGAA(A/G)CCCAG reference, missense
rs9282642 - 122,106,306(+) GATGA(A/G)TGTTT reference, missense
rs9282648 - 122,119,511(+) CATGC(A/G)ACAAA reference, missense
rs2681417 - 122,106,350(+) ATGGT(A/G)TTATG reference, missense
rs2001750 -- 122,107,670(+) CAGCG(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD86 Gene

Variant ID Type Subtype PubMed ID
esv33139 CNV Loss 17666407
nsv3972 CNV Insertion 18451855
nsv528646 CNV Loss 19592680
esv1959984 CNV Deletion 18987734
esv2500835 CNV Deletion 19546169

Variation tolerance for CD86 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD86 Gene

HapMap Linkage Disequilibrium report
CD86
Human Gene Mutation Database (HGMD)
CD86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD86 Gene

Disorders for CD86 Gene

MalaCards: The human disease database

(22) MalaCards diseases for CD86 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphohistiocytoid mesothelioma
autoimmune disease of central nervous system
gallbladder squamous cell carcinoma
  • epidermoid gallbladder carcinoma
epididymis cancer
  • malignant epididymal tumor
epididymis adenocarcinoma
  • adenocarcinoma of the epididymis
- elite association - COSMIC cancer census association via MalaCards
Search CD86 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD86

Genetic Association Database (GAD)
CD86
Human Genome Epidemiology (HuGE) Navigator
CD86
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD86
genes like me logo Genes that share disorders with CD86: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD86 Gene

Publications for CD86 Gene

  1. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PMID: 12606712) Zhang X. … Nathenson S.G. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23 67
  2. A novel B7-2 (CD86) splice variant with a putative negative regulatory role. (PMID: 18322188) Kapsogeorgou E.K. … Manoussakis M.N. (J. Immunol. 2008) 3 23
  3. A functional CD86 polymorphism associated with asthma and related allergic disorders. (PMID: 17513529) Corydon T.J. … rglum A.D. (J. Med. Genet. 2007) 3 23
  4. A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86. (PMID: 18005680) Chaudhry A. … Rath S. (Cell Host Microbe 2007) 3 23
  5. Expression of the costimulatory molecule CD86, but not CD80, in keratinocytes of normal cervical epithelium and human papillomavirus-16 positive low squamous intraepithelial lesions. (PMID: 17386046) Ortiz-SA!nchez E. … Garrido E. (Int. J. Gynecol. Cancer 2007) 3 23

Products for CD86 Gene

Sources for CD86 Gene

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