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Aliases for CD86 Gene

Aliases for CD86 Gene

  • CD86 Molecule 2 3 5
  • CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen) 2 3
  • CTLA-4 Counter-Receptor B7.2 3 4
  • CD28LG2 3 4
  • FUN-1 3 4
  • BU63 3 4
  • B70 3 4
  • B-Lymphocyte Activation Antigen B7-2 3
  • T-Lymphocyte Activation Antigen CD86 3
  • B-Lymphocyte Antigen B7-2 2
  • Activation B7-2 Antigen 4
  • CD86 Antigen 4
  • LAB72 3
  • B7-2 3
  • B7.2 3

External Ids for CD86 Gene

Previous HGNC Symbols for CD86 Gene

  • CD28LG2

Previous GeneCards Identifiers for CD86 Gene

  • GC03P118451
  • GC03P121633
  • GC03P123055
  • GC03P123095
  • GC03P123256
  • GC03P121774
  • GC03P119148

Summaries for CD86 Gene

Entrez Gene Summary for CD86 Gene

  • This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

GeneCards Summary for CD86 Gene

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include receptor binding and coreceptor activity. An important paralog of this gene is CD80.

UniProtKB/Swiss-Prot for CD86 Gene

  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD86 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD86 Gene

Genomics for CD86 Gene

Regulatory Elements for CD86 Gene

Enhancers for CD86 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G122073 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +22.1 22068 7.1 HDGF TBP PKNOX1 FOXA2 TBL1XR1 WRNIP1 SIN3A BMI1 RFX5 YY1 CD86 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA HCLS1
GH03G122002 1.5 FANTOM5 Ensembl ENCODE 13.9 -51.3 -51300 2.9 BMI1 CBX5 EGR1 ZNF207 RELB ETV6 IKZF2 CREM CBFB JUNB IQCB1 SLC15A2 CD86 ENSG00000202388 ILDR1 CSTA EAF2 HCLS1 LOC101927010
GH03G121997 1.4 FANTOM5 Ensembl ENCODE 13.5 -56.9 -56862 2.2 ZBTB21 JUN BMI1 EBF1 RELA FOSL1 ZFHX2 ZNF316 GATA2 EED SLC15A2 CD86 EAF2 ENSG00000202388 ILDR1 IQCB1 CSTA HCLS1 LOC101927010
GH03G122056 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +3.2 3184 4.3 ZNF146 RELA EED RELB IKZF2 ZNF280D MTA2 NR2F1 BHLHE40 JUNB ENSG00000202388 CD86 IQCB1 HCLS1 EAF2 ILDR1
GH03G121957 1.3 FANTOM5 Ensembl ENCODE 13.1 -97.4 -97374 0.4 MTA2 GATAD2B EBF1 DPF2 TBX21 RAD51 SMARCA4 POLR2A EED TARDBP CD86 IQCB1 HCLS1 EAF2 CSTA GC03P121966 SLC15A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD86 on UCSC Golden Path with GeneCards custom track

Promoters for CD86 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157286 438 800 TBP TBL1XR1 RELA CBX5 POLR2A EED ETV6 IKZF2 CREM MTA2

Transcription factor binding sites by QIAGEN in the CD86 gene promoter:

Genomic Location for CD86 Gene

Chromosome:
3
Start:
122,055,362 bp from pter
End:
122,121,143 bp from pter
Size:
65,782 bases
Orientation:
Plus strand

Genomic View for CD86 Gene

Genes around CD86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD86 Gene

Proteins for CD86 Gene

  • Protein details for CD86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42081-CD86_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD86
    Protein Accession:
    P42081
    Secondary Accessions:
    • A0N0P0
    • B7Z2F3
    • B7Z702
    • E7ETN5
    • E9PC27
    • Q13655
    • Q6FHB1
    • Q6GTS4
    • Q7M4L5

    Protein attributes for CD86 Gene

    Size:
    329 amino acids
    Molecular mass:
    37682 Da
    Quaternary structure:
    • Homodimer. Interacts with MARCH8.
    • (Microbial infection) Interacts with adenovirus subgroup b fiber protein.

    Three dimensional structures from OCA and Proteopedia for CD86 Gene

    Alternative splice isoforms for CD86 Gene

neXtProt entry for CD86 Gene

Post-translational modifications for CD86 Gene

  • Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
  • Glycosylation at Asn33, Asn47, posLast=135135, Asn146, posLast=154154, posLast=177177, posLast=192192, and posLast=213213
  • Modification sites at PhosphoSitePlus

Antibody Products

Assay Products

  • Cloud-Clone Corp Assay Kits for CD86

No data available for DME Specific Peptides for CD86 Gene

Domains & Families for CD86 Gene

Protein Domains for CD86 Gene

Suggested Antigen Peptide Sequences for CD86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD86: view

No data available for UniProtKB/Swiss-Prot for CD86 Gene

Function for CD86 Gene

Molecular function for CD86 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on monocytes,dendritic cells and activated B,T and natural killer cells (antigen presenting cells)
UniProtKB/Swiss-Prot Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Ontology (GO) - Molecular Function for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 7694363
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
genes like me logo Genes that share ontologies with CD86: view
genes like me logo Genes that share phenotypes with CD86: view

Animal Models for CD86 Gene

MGI Knock Outs for CD86:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD86 Gene

Localization for CD86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD86 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD86 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 23981064
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IEA 9915850
genes like me logo Genes that share ontologies with CD86: view

Pathways & Interactions for CD86 Gene

genes like me logo Genes that share pathways with CD86: view

Gene Ontology (GO) - Biological Process for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0002224 toll-like receptor signaling pathway IEA --
GO:0002250 adaptive immune response IEA --
GO:0002309 T cell proliferation involved in immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with CD86: view

No data available for SIGNOR curated interactions for CD86 Gene

Drugs & Compounds for CD86 Gene

(17) Drugs for CD86 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma binder, Target, antagonist 197
Belatacept Approved Pharma inhibitor, Target 0
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target 0
antithymocyte globulin Pharma binder 0
ASP2408 Pharma 0

(11) Additional Compounds for CD86 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD86: view

Transcripts for CD86 Gene

Unigene Clusters for CD86 Gene

CD86 molecule:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD86 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for CD86 Gene

GeneLoc Exon Structure for
CD86
ECgene alternative splicing isoforms for
CD86

Expression for CD86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD86 Gene

mRNA differential expression in normal tissues according to GTEx for CD86 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for CD86 Gene

This gene is overexpressed in Heart (31.5), Monocytes (26.3), and Retina (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD86 Gene



Protein tissue co-expression partners for CD86 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD86 Gene:

CD86

SOURCE GeneReport for Unigene cluster for CD86 Gene:

Hs.171182

mRNA Expression by UniProt/SwissProt for CD86 Gene:

P42081-CD86_HUMAN
Tissue specificity: Expressed by activated B-lymphocytes and monocytes.

Evidence on tissue expression from TISSUES for CD86 Gene

  • Nervous system(4.4)
  • Lymph node(4.1)
  • Spleen(4.1)
  • Blood(3.8)
  • Bone marrow(3)
  • Intestine(2.8)
  • Lung(2.7)
  • Skin(2.6)
  • Liver(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CD86: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD86 Gene

Orthologs for CD86 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD86 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia CD86 34 35
  • 78.84 (n)
cow
(Bos Taurus)
Mammalia CD86 34 35
  • 74.38 (n)
rat
(Rattus norvegicus)
Mammalia Cd86 34
  • 68.86 (n)
mouse
(Mus musculus)
Mammalia Cd86 34 16 35
  • 68.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CD86 35
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD86 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD86 34 35
  • 51.17 (n)
Species where no ortholog for CD86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD86 Gene

ENSEMBL:
Gene Tree for CD86 (if available)
TreeFam:
Gene Tree for CD86 (if available)

Paralogs for CD86 Gene

Paralogs for CD86 Gene

genes like me logo Genes that share paralogs with CD86: view

Variants for CD86 Gene

Sequence variations from dbSNP and Humsavar for CD86 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000050127 -- 122,118,948(+) TCTGA(C/T)TGCAT intron-variant
rs1000050980 -- 122,071,952(+) TCAAC(C/T)CCTAT intron-variant
rs1000162711 -- 122,091,831(+) CAGCT(A/G)ATGGC intron-variant
rs1000219103 -- 122,057,809(+) GAATT(G/T)TATAT intron-variant
rs1000231377 -- 122,061,269(+) ATAAA(C/T)CTTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD86 Gene

Variant ID Type Subtype PubMed ID
esv1959984 CNV deletion 18987734
esv2500835 CNV deletion 19546169
esv33139 CNV loss 17666407
nsv3972 CNV insertion 18451855
nsv528646 CNV loss 19592680

Variation tolerance for CD86 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD86 Gene

Human Gene Mutation Database (HGMD)
CD86
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD86 Gene

Disorders for CD86 Gene

MalaCards: The human disease database

(27) MalaCards diseases for CD86 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gallbladder squamous cell carcinoma
  • epidermoid gallbladder carcinoma
myocarditis
  • myocardial inflammation
acute myocarditis
plague
  • yersiniosis
skin carcinoma in situ
  • carcinoma in situ of skin
- elite association - COSMIC cancer census association via MalaCards
Search CD86 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD86

Genetic Association Database (GAD)
CD86
Human Genome Epidemiology (HuGE) Navigator
CD86
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD86
genes like me logo Genes that share disorders with CD86: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD86 Gene

Publications for CD86 Gene

  1. A functional CD86 polymorphism associated with asthma and related allergic disorders. (PMID: 17513529) Corydon T.J. … rglum A.D. (J. Med. Genet. 2007) 3 22 46 64
  2. A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis. (PMID: 16712644) Abdallah A.M. … Welsh K.I. (Int. J. Immunogenet. 2006) 3 22 46 64
  3. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PMID: 16223675) MarA-n L.A. … Alvarez-LA^pez M.R. (Transpl. Immunol. 2005) 3 22 46 64
  4. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PMID: 12606712) Zhang X. … Nathenson S.G. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 22 64
  5. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M. … Tokunaga K. (Genes Immun. 2000) 3 22 46 64

Products for CD86 Gene

Sources for CD86 Gene

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