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CD86 Gene

protein-coding   GIFtS: 66
GCID: GC03P121774

CD86 Molecule

(Previous names: CD86 antigen (CD28 antigen ligand 2, B7-2 antigen))
(Previous symbol: CD28LG2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD86 Molecule1 2     B-Lymphocyte Antigen B7-21
CD28LG21 2 3 5     B7-22
CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen)1 2     B7.22
B702 3     B-Lymphocyte Activation Antigen B7-22
BU632 3     T-Lymphocyte Activation Antigen CD862
FUN-12 3     Activation B7-2 Antigen3
CTLA-4 Counter-Receptor B7.22 3     CD86 Antigen3
LAB722 5     

External Ids:    HGNC: 17051   Entrez Gene: 9422   Ensembl: ENSG000001140137   OMIM: 6010205   UniProtKB: P420813   

Export aliases for CD86 gene to outside databases

Previous GC identifers: GC03P118451 GC03P121633 GC03P123055 GC03P123095 GC03P123256 GC03P119148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD86 Gene:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is
expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28
antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a
costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated
protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results
in several transcript variants encoding different isoforms.(provided by RefSeq, May 2011)

GeneCards Summary for CD86 Gene:
CD86 (CD86 molecule) is a protein-coding gene. Diseases associated with CD86 include benign mesothelioma, and chronic mucocutaneous candidiasis. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is CD80.

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081
Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2
production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and
costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24
hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative
regulator of T-cell activation

Gene Wiki entry for CD86 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD86 gene promoter:
         AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD86 promoter sequence
   Search Chromatin IP Primers for CD86

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD86


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q21

CD86 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD86 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P121774:  view genomic region     (about GC identifiers)

Start:
121,774,209 bp from pter      End:
121,839,990 bp from pter
Size:
65,782 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD86_HUMAN, P42081 (See protein sequence)
Recommended Name: T-lymphocyte activation antigen CD86 precursor  
Size: 329 amino acids; 37682 Da
Subunit: Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts
with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses
2 PDB 3D structures from and Proteopedia for CD86:
1I85 (3D)        1NCN (3D)    
Secondary accessions: A0N0P0 B7Z2F3 B7Z702 E7ETN5 E9PC27 Q13655 Q6FHB1 Q6GTS4 Q7M4L5
Alternative splicing: 6 isoforms:  P42081-1   P42081-3   P42081-2   P42081-4   P42081-5   P42081-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD86: NX_P42081

Explore proteomics data for CD86 at MOPED

Post-translational modifications: 

  • Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation1
  • Glycosylation2 at Asn33, Asn47, Asn135, Asn146, Asn154, Asn177, Asn192, Asn213
  • Modification sites at PhosphoSitePlus

  • See CD86 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001193853.1  NP_001193854.1  NP_008820.3  NP_787058.4  NP_795711.1  

    ENSEMBL proteins: 
     ENSP00000418988   ENSP00000420230   ENSP00000332049   ENSP00000419116   ENSP00000377248  
     ENSP00000417195   ENSP00000264468  
    Reactome Protein details: P42081

    CD86 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for CD86 (B7-2/CD86)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD86
    OriGene Protein Over-expression Lysate for CD86
    OriGene MassSpec for CD86
    OriGene Custom Protein Services for CD86
    GenScript Custom Purified and Recombinant Proteins Services for CD86
    Novus Biologicals CD86 Proteins
    Novus Biologicals CD86 Lysates
    Sino Biological Recombinant Protein for CD86
    Sino Biological Cell Lysate for CD86
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD86 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD86
    R&D Systems Antibodies for CD86 (B7-2/CD86)
    OriGene Antibodies for CD86
    OriGene Custom Antibody Services for CD86
    Novus Biologicals CD86 Antibodies
    Abcam antibodies for CD86
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD86
    LSBio Antibodies in human, mouse, rat for CD86

    CD86 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD86
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD86
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P42081

    ProtoNet protein and cluster: P42081

    1 Blocks protein domain: IPB003596 Immunoglobulin V-type

    UniProtKB/Swiss-Prot: CD86_HUMAN, P42081
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD86 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD86_HUMAN, P42081
    Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2
    production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and
    costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24
    hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative
    regulator of T-cell activation

         Genatlas biochemistry entry for CD86:
    cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on
    monocytes,dendritic cells and activated B,T and natural killer cells (antigen presenting cells)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7694363
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI11279501
    GO:0015026coreceptor activity NAS9915850
         
    CD86 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd86):
     behavior/neurological  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  nervous system 

    CD86 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD86: Cd86tm1Shr Cd86tm2Shr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD86
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD86

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD86
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD86

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD86:
    hsa-mir-124-3p (MIRT022558)

    Block miRNA regulation of human, mouse, rat CD86 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD86 (see all 13):
    hsa-miR-98 hsa-miR-577 hsa-miR-767-3p hsa-let-7d hsa-miR-496 hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCD86 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD86
    Predesigned siRNA for gene silencing in human, mouse, rat CD86

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD86

    Clone
    Products:
         
    OriGene clones in human, mouse for CD86 (see all 11)
    OriGene ORF clones in mouse, rat for CD86
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD86 (NM_175862)
    Sino Biological Human cDNA Clone for CD86
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD86
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD86

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD86
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD86 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD86


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD86_HUMAN, P42081: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    lysosome2
    nucleus2
    vacuole2
    cytosol1
    endoplasmic reticulum1
    endosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane IC9915850
    GO:0043231intracellular membrane-bounded organelle IEA--

    CD86 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD86 About   (see all 23)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Type I diabetes mellitus0.69
    Viral myocarditis0.40
    Graft-versus-host disease0.65
    THC Differentiation Pathway0.38
    2CD28 co-stimulation
    CD28 co-stimulation0.66
    CTLA4 inhibitory signaling0.32
    CD28 dependent PI3K/Akt signaling0.66
    CTLA4 Signaling0.30
    Costimulation by the CD28 family0.44
    CD28 dependent Vav1 pathway0.00
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CD86
        Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD86 (see all 8)
        THC Differentiation Pathway
    CTLA4 Signaling
    Nur77 Signaling in T-Cell
    ICos-ICosL Pathway in T-Helper Cell
    PKC-Theta Pathway

    4 GeneGo (Thomson Reuters) Pathways for CD86
        Immune response ICOS pathway in T-helper cell
    Immune response IL-22 signaling pathway
    Immune response CD28 signaling
    Immune response NFAT in immune response

    Selected BioSystems Pathways for CD86 (see all 6)
        Allograft Rejection
    Toll-like receptor signaling pathway
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells
    Inflammatory Response Pathway


    Selected Reactome Pathways for CD86 (see all 6)
        CD28 dependent Vav1 pathway
    Constitutive PI3K/AKT Signaling in Cancer
    CTLA4 inhibitory signaling
    PIP3 activates AKT signaling
    CD28 co-stimulation


    Selected Kegg Pathways  (Kegg details for CD86) (see all 11):
        Cell adhesion molecules (CAMs)
    Toll-like receptor signaling pathway
    Intestinal immune network for IgA production
    Type I diabetes mellitus
    Transcriptional misregulation in cancer


    CD86 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD86 (see all 11): 
              Cell Surface Markers in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD86

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD86 (P420811, 3 ENSP000003320494) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTLA4P164101, 3, ENSP000003039394EBI-1030956,EBI-1030991 I2D: score=3 STRING: ENSP00000303939
    CD28P107473, ENSP000003248904I2D: score=1 STRING: ENSP00000324890
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CD80P336813, ENSP000002642464I2D: score=1 STRING: ENSP00000264246
    MARCH1Q8TCQ13, ENSP000003456764I2D: score=1 STRING: ENSP00000345676
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878response to yeast IEA--
    GO:0002224toll-like receptor signaling pathway IEA--
    GO:0002309T cell proliferation involved in immune response IEA--
    GO:0002668negative regulation of T cell anergy IEA--
    GO:0006955immune response TAS7694363

    CD86 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD86

    3 DrugBank Compounds for CD86    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AbataceptBMS-188667 (see all 9)332348-12-6targetantagonist18041889 16357751 16932686 17020493 16573350 11752352 20080922 17212998 16971318
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600
    BelataceptBMS-224818 (see all 2)706808-37-9target--18269922

    Selected Novoseek inferred chemical compound relationships for CD86 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ctla4-ig 55.3 5 7545666 (2), 7964482 (1), 8892613 (1)
    il-12 46.1 11 12195617 (4), 12672403 (3)
    1-chloro-24-dinitrobenzene 42.8 17 9394834 (5), 10552213 (3), 17636246 (2), 17118622 (1)
    triptolide 32.9 6 12230943 (3), 15663903 (3)
    mannose 32 5 11522239 (3), 12930919 (1), 16567867 (1)
    allergens 27 4 17118622 (2), 18547706 (1)
    dextran 8.16 2 16567867 (1), 8985101 (1)
    cyclosporin a 7.48 12 8757955 (2), 10552213 (2), 10594746 (1), 9550652 (1) (see all 5)
    fitc 7.34 1 10936095 (1)
    flagellin 5.65 1 12734364 (1)



    CD86 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD86 gene (5 alternative transcripts): 
    NM_001206924.1  NM_001206925.1  NM_006889.4  NM_175862.4  NM_176892.1  

    Unigene Cluster for CD86:

    CD86 molecule
    Hs.171182  [show with all ESTs]
    Unigene Representative Sequence: NM_006889
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469710 ENST00000493101 ENST00000330540(uc003eet.3 uc011bjo.2 uc011bjp.2 uc003eeu.3 uc021xcz.1)
    ENST00000478390 ENST00000483949 ENST00000482356 ENST00000393627 ENST00000478741
    ENST00000264468
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD86 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD86 (see all 13):
    hsa-miR-98 hsa-miR-577 hsa-miR-767-3p hsa-let-7d hsa-miR-496 hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCD86 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD86
    Predesigned siRNA for gene silencing in human, mouse, rat CD86
    Clone
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    OriGene clones in human, mouse for CD86 (see all 11)
    OriGene ORF clones in mouse, rat for CD86
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD86 (NM_175862)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD86
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD86
    Primer
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    OriGene qPCR primer pairs and template standards for CD86
    OriGene qSTAR qPCR primer pairs in human, mouse for CD86
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD86
      QuantiTect SYBR Green Assays in human, mouse, rat CD86
      QuantiFast Probe-based Assays in human, mouse, rat CD86

    Additional mRNA sequence: 

    AK291497.1 AK294663.1 AK301237.1 AK313103.1 AK316203.1 BC040261.1 CR541844.1 L25259.1 
    U04343.1 

    4 DOTS entries:

    DT.109241  DT.100752216  DT.100694044  DT.95090151 

    Selected AceView cDNA sequences (see all 62):

    L25259 BM984686 BQ109553 BG236280 AA573388 CB240783 AA729846 CB528714 
    Z41058 BV174889 U04343 BQ006884 AI989391 CR600347 AI080151 CB529005 
    AA927298 CD688144 BF064222 BX371662 BX369321 AL576009 BQ002799 AI651717 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CD86    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                      -                                                         
    SP2:        -     -     -     -           -                                                         
    SP3:                          -           -                                                         
    SP4:                                                                                                
    SP5:                                -     -                                                         


    ECgene alternative splicing isoforms for CD86

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD86 expression in normal human tissues (normalized intensities)      CD86 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTGCAG
    CD86 Expression
    About this image


    CD86 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 15 entries
             Monocytes Peripheral Blood
             Immunosuppressive dendritic cells
             Mature dendritic-like cells
             Peripheral Blood Monocytes (PB CD14+)   
             monocytes   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood Monocytes (CD14+)   
     
     NULL (Uncategorized)
             Immature dendritic-like cells
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    CD86 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD86 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171182

    UniProtKB/Swiss-Prot: CD86_HUMAN, P42081
    Tissue specificity: Expressed by activated B-lymphocytes and monocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD86 (see all 11): 
              Cell Surface Markers in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD86 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd861 , 5 CD86 antigen1, 5 68.37(n)1
    52.38(a)1
      16 (25.72 cM)5
    125241  NM_019388.31  NP_062261.31 
     366038695 
    chicken
    (Gallus gallus)
    Aves CD861 CD86 molecule 51.17(n)
    36.33(a)
      427944  NM_001037839.1  NP_001032928.1 


    ENSEMBL Gene Tree for CD86 (if available)
    TreeFam Gene Tree for CD86 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD86 gene
    CD802  

    CD86 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD86 (see all 1209)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351871201,2
    C--119170022(+) CTTCT-/GAAGCCCC 3 -- int10--------
    rs58522891,2
    C--119170023(+) TTCTGAAG/-CCCCG 5 -- us2k1 int11Minor allele frequency- -:0.50NA 2
    rs2002163701,2
    C--119170023(+) TTCTGA/CAGCCC 5 -- us2k1 int10--------
    rs105615301,2
    C--119179395(+) CACCA-/GTGTGTG 5 -- int10--------
    rs631148611,2
    C--119184056(+) TTACC-/TTTTTT 5 -- int11Minor allele frequency- T:0.00CSA 2
    rs2006711461,2
    C--119184057(+) TTACCC/TTTTTT 5 -- int10--------
    rs113752481,2
    C--119187208(+) CTCCCT/-TATAT 5 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1478861171,2
    C--119187648(+) TAAGA-/TTTTTTT 5 -- int10--------
    rs350842741,2
    C--119192986(+) TTTTTT/-AGTAC 5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs97991281,2
    C,A,H--119193989(+) AAAAAA/TATATA 5 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for CD86 (121774209 - 121839990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD86:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1959984CNV Deletion18987734
    esv2500835CNV Deletion19546169
    nsv3972CNV Insertion18451855
    esv33139CNV Loss17666407
    nsv528646CNV Loss19592680

    Human Gene Mutation Database (HGMD): CD86
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD86
    DNA2.0 Custom Variant and Variant Library Synthesis for CD86

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601020    OMIM disorders: --

    Selected diseases for CD86 (see all 114):    About MalaCards
    benign mesothelioma    chronic mucocutaneous candidiasis    allergic encephalomyelitis    wegener's granulomatosis
    gastrointestinal system disease    common variable immunodeficiency    chronic graft versus host disease    optic neuritis
    schistosomiasis    vernal keratoconjunctivitis    neuritis    polymyositis
    myasthenia gravis    sclerosing cholangitis    lymphocytic choriomeningitis    candidiasis
    dermatomyositis    pulmonary sarcoidosis    primary sclerosing cholangitis    encephalomyelitis

    12 diseases from the University of Copenhagen DISEASES database for CD86:
    Carcinoma     Hypersensitivity reaction type II disease     Tetanus     Benign mesothelioma
    Leukemia     Colorectal cancer     Asthma     Melanoma
    Arthritis     Multiple sclerosis     Connective tissue disease     Lymphoma

    CD86 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CD86 gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 54.7 24 9003248 (1), 10209502 (1), 17530637 (1), 17371857 (1) (see all 23)
    tumors 40.2 54 10352284 (5), 7543078 (3), 12195617 (2), 9139887 (2) (see all 37)
    hypersensitivity contact 32.6 1 10552213 (1)
    lupus erythematosus systemic 31.3 4 11196673 (2), 15870153 (2)
    multiple sclerosis 25.4 10 16513684 (2), 10227430 (1), 15544628 (1), 12672403 (1) (see all 6)
    malignant ascites 24.2 3 10606960 (2), 9719501 (1)
    autoimmune diseases 23.6 9 10201965 (1), 15870153 (1), 12223069 (1), 7500044 (1) (see all 5)
    goiter nodular 21 2 15504312 (1), 16220002 (1)
    granuloma 19.2 10 8686742 (4), 10461083 (2), 15019278 (2), 14518246 (1) (see all 5)
    sjogrens syndrome 14.4 1 11302869 (1)

    Genetic Association Database (GAD): CD86
    Human Genome Epidemiology (HuGE) Navigator: CD86 (42 documents)

    Export disorders for CD86 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD86 gene, integrated from 10 sources (see all 618):
    (articles sorted by number of sources associating them with CD86)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PubMed id 12606712)1, 2, 9 Zhang X.... Nathenson S.G. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). (PubMed id 7541777)1, 2, 9 Jellis C.L.... Gray G.S. (Immunogenetics 1995)
    3. A functional CD86 polymorphism associated with asthma and related allergic disorders. (PubMed id 17513529)1, 4, 9 Corydon T.J....rglum A.D. (J. Med. Genet. 2007)
    4. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PubMed id 16223675)1, 4, 9 MarA-n L.A....Alvarez-LA^pez M.R. (Transpl. Immunol. 2005)
    5. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PubMed id 15942292)1, 4, 9 Handa T....Mishima M. ( international review of thoracic diseases 2005)
    6. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)1, 4, 9 Matsushita M....Tokunaga K. (Genes Immun. 2000)
    7. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. (PubMed id 7694363)1, 2, 9 Freeman G.J.... Nadler L.M. (Science 1993)
    8. A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis. (PubMed id 16712644)1, 4, 9 Abdallah A.M....Welsh K.I. (Int. J. Immunogenet. 2006)
    9. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)1, 4, 9 Teutsch S.M....Stewart G.J. (J. Neuroimmunol. 2004)
    10. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PubMed id 12582153)1, 2, 9 Goto E.... Hotta H. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 942 HGNC: 1705 AceView: CD86 Ensembl:ENSG00000114013 euGenes: HUgn942
    ECgene: CD86 Kegg: 942 H-InvDB: CD86

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD86 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD86 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD86

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD86 gene:
    Search GeneIP for patents involving CD86

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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