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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD86 Gene

protein-coding GIFtS: 66
GCID: GC03P121774

CD86 molecule

(Previous names: CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) )
(Previous symbol: CD28LG2)

Explore 112 diseases affiliated with
CD86 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD86 Molecule¹ ²		FUN-1² ³
CD28LG2¹ ² ³ ⁵		CTLA-4 Counter-Receptor B7.2² ³
B7-2¹ ²		LAB72² ⁵
B7.2¹ ²		B-Lymphocyte Activation Antigen B7-2²
CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen)¹ ²		T-Lymphocyte Activation Antigen CD86²
B70² ³		Activation B7-2 Antigen³
BU63² ³		CD86 Antigen³

External Ids:	HGNC: 1705¹	Entrez Gene: 942²	Ensembl: ENSG00000114013⁷	OMIM: 601020⁵	UniProtKB: P42081³

Export aliases for CD86 gene to outside databases

Previous GC identifers: GC03P118451 GC03P121633 GC03P123055 GC03P123095 GC03P123256 GC03P119148

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD86:

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is

expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28

antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory

signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4

negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several

transcript variants encoding different isoforms.(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081

Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2

production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and

costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours

after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of

T-cell activation

Gene Wiki entry for CD86

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD86 gene promoter:
AP-1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD86 promoter sequence

Search SABiosciences Chromatin IP Primers for CD86

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD86

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q21

CD86 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD86 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P121774: view genomic region (about GC identifiers)

Start:	121,774,213 bp from pter	End:	121,839,983 bp from pter
Size:	65,771 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081 (See protein sequence)

Recommended Name: T-lymphocyte activation antigen CD86 precursor

Size: 329 amino acids; 37682 Da

Subunit: Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with

adenovirus subgroup B fiber proteins and acts as a receptor for these viruses

Subcellular location: Cell membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for CD86:

1I85 (3D)

1NCN (3D)

Secondary accessions: A0N0P0 Q13655 Q6FHB1 Q6GTS4 Q7M4L5

Alternative splicing: 4 isoforms: P42081-1 P42081-3 P42081-2 P42081-4

Explore the universe of human proteins at neXtProt for CD86: NX_P42081

Post-translational modifications:

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42081

CD86 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001193853.1 NP_001193854.1 NP_008820.3 NP_787058.4 NP_795711.1

ENSEMBL proteins:

ENSP00000418988 ENSP00000420230 ENSP00000332049 ENSP00000419116 ENSP00000377248

ENSP00000417195 ENSP00000264468

Reactome Protein details: P42081
Human Recombinant Protein Products:

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	Novus Biologicals CD86 Proteins Novus Biologicals CD86 Lysates
	Sino Biological Recombinant Protein for CD86
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IC	9915850
GO:0043231	intracellular membrane-bounded organelle	IEA	--

CD86 for ontologies About GeneDecksing

CD86 Antibody Products:

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Assay Products for CD86:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD86 for domains About GeneDecksing

4 InterPro domains/families:

IPR003596 Ig_V-set_subgr

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P42081

ProtoNet protein and cluster: P42081

1 Blocks protein family: IPB003596 Immunoglobulin V-type

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081

Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2

production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and

costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours

after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of

T-cell activation

Genatlas biochemistry entry for CD86:

cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on monocytes,dendritic

cells and activated B,T and natural killer cells (antigen presenting cells)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD86 Browse MicroRNA Expression Plasmids
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		hsa-miR-98 hsa-miR-577 hsa-miR-767-3p hsa-let-7d hsa-miR-496 hsa-let-7c hsa-let-7i hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: CD86 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD86

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	7694363
GO:0005515	protein binding	IPI	--
GO:0015026	coreceptor activity	NAS	9915850

CD86 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CD86: Cd86^tm1Shr Cd86^tm2Shr
     8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd86):

behavior/neurological	cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	muscle	nervous system

CD86 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

Allograft rejection

Allograft rejection	1.00	THC Differentiation Pathway	0.39
Type I diabetes mellitus	0.67	Intestinal immune network for IgA production	0.38
Graft-versus-host disease	0.63	Viral myocarditis	0.33
Autoimmune thyroid disease	0.60

CD28 co-stimulation

CD28 co-stimulation	1.00	CD28 dependent Vav1 pathway	0.38
CD28 dependent PI3K/Akt signaling	0.66	CTLA4 Signaling	0.15
Costimulation by the CD28 family	0.41

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CD86

	Immune response CD28 signaling
	Immune response IL-22 signaling pathway
	Immune response NFAT in immune response
	Immune response ICOS pathway in T-helper cell

2 R&D Systems Pathways for CD86

	Th1 Differentiation
	Th17 Differentiation

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD86 (see all 8)

	THC Differentiation Pathway
	CTLA4 Signaling
	Nur77 Signaling in T-Cell
	ICos-ICosL Pathway in T-Helper Cell
	PKC-Theta Pathway

4 GeneGo (Thomson Reuters) Pathways for CD86

	Immune response ICOS pathway in T-helper cell
	Immune response IL-22 signaling pathway
	Immune response CD28 signaling
	Immune response NFAT in immune response

4 BioSystems Pathways for CD86

	Toll-like receptor signaling pathway
	TCR signaling in naive CD4+ T cells
	TCR signaling in naive CD8+ T cells
	Inflammatory Response Pathway

5/34 Reactome Pathways for CD86 (see all 34)

	CD28 dependent Vav1 pathway
	Costimulation by the CD28 family
	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction

5/10 Kegg Pathways (Kegg details for CD86) (see all 10):

	Cell adhesion molecules (CAMs)
	Toll-like receptor signaling pathway
	Intestinal immune network for IgA production
	Type I diabetes mellitus
	Autoimmune thyroid disease

CD86 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD86

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for CD86 (P42081^{1, 3} ENSP00000332049⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTLA4	P16410¹^,³, ENSP00000303939⁴	EBI-1030956,EBI-1030991 I2D: score=3 STRING: ENSP00000303939
CD28	P10747³, ENSP00000324890⁴	I2D: score=1 STRING: ENSP00000324890
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
CD80	P33681³, ENSP00000264246⁴	I2D: score=1 STRING: ENSP00000264246
MARCH1	Q8TCQ1³, ENSP00000345676⁴	I2D: score=1 STRING: ENSP00000345676

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002224	toll-like receptor signaling pathway	IEA	--
GO:0006955	immune response	TAS	7694363
GO:0007267	cell-cell signaling	IC	9915850
GO:0008284	positive regulation of cell proliferation	TAS	7513726
GO:0019048	virus-host interaction	IEA	--

CD86 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD86 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD86

2 DrugBank Compounds for CD86 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abatacept	CTLA4-Ig (see all 8)	332348-12-6	target	antagonist	18041889 16357751 16932686 17020493 16573350 11752352 20080922 17212998 16971318
Antithymocyte globulin	rabbit ATG (see all 3)	--	target	--	12586600

10/22 Novoseek chemical compound relationships for CD86 gene (see all 22) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ctla4-ig	55.3	5	7545666 (2), 7964482 (1), 8892613 (1)
il-12	46.1	11	12195617 (4), 12672403 (3)
1-chloro-24-dinitrobenzene	42.8	17	9394834 (5), 10552213 (3), 17636246 (2), 17118622 (1)
triptolide	32.9	6	12230943 (3), 15663903 (3)
mannose	32	5	11522239 (3), 12930919 (1), 16567867 (1)
allergens	27	4	17118622 (2), 18547706 (1)
dextran	8.16	2	16567867 (1), 8985101 (1)
cyclosporin a	7.48	12	8757955 (2), 10552213 (2), 10594746 (1), 9550652 (1) (see all 5)
fitc	7.34	1	10936095 (1)
flagellin	5.65	1	12734364 (1)

Search CenterWatch for drugs/clinical trials and news about CD86

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD86 gene (5 alternative transcripts):

NM_001206924.1 NM_001206925.1 NM_006889.4 NM_175862.4 NM_176892.1

Unigene Cluster for CD86:

CD86 molecule

Hs.171182 [show with all ESTs]

Unigene Representative Sequence: NM_006889

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000469710 ENST00000493101 ENST00000330540(uc003eet.3 uc011bjo.2 uc011bjp.2 uc003eeu.3 uc021xcz.1)

ENST00000478390 ENST00000483949 ENST00000482356 ENST00000393627 ENST00000478741

ENST00000264468

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		hsa-miR-98 hsa-miR-577 hsa-miR-767-3p hsa-let-7d hsa-miR-496 hsa-let-7c hsa-let-7i hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: CD86 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD86

Additional cDNA sequence:

AK291497.1 AK294663.1 AK301237.1 AK313103.1 AK316203.1 BC040261.1 CR541844.1 L25259.1

U04343.1

4 DOTS entries:

DT.109241 DT.100752216 DT.100694044 DT.95090151

24/62 AceView cDNA sequences (see all 62):

BV174889 CB240783 BQ109553 BM984686 AA573388 Z41058 L25259 BG236280

AA729846 AI080151 U04343 CB528714 CR600347 BQ006884 AI989391 AA830295

BG057636 BX351622 BQ002799 BX369321 AL576009 CD688144 BQ003061 BQ109523

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CD86 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b
SP1:													-
SP2:			-		-		-		-				-
SP3:									-				-
SP4:
SP5:											-		-

ECgene alternative splicing isoforms for CD86

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD86 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTGCAG

About this image

CD86 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Myeloid Dendritic Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Immature dendritic-like cells (Derivation of dendri...)

Mature dendritic-like cells (Derivation of dendri...)

Monocyte-like cells (Derivation of dendri...)

See CD86 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD86

SOURCE GeneReport for Unigene cluster: Hs.171182

UniProtKB/Swiss-Prot: CD86_HUMAN, P42081

Tissue specificity: Expressed by activated B-lymphocytes and monocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including CD86 (see all 11):

Cell Surface Markers in human mouse rat

Antiviral Response in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD86

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD86 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd86^{1 , 5}	CD86 antigen^{1, 5}	67.91(n)¹ 52.03(a)¹		16 (25.72 cM)⁵ 12524¹ NM_019388.3¹ NP_062261.3¹ 36603869⁵
chicken (Gallus gallus)	Aves	CD86¹	CD86 molecule	50.83(n) 35.95(a)		427944 NM_001037839.1 NP_001032928.1

ENSEMBL Gene Tree for CD86 (if available)
TreeFam Gene Tree for CD86 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CD86 gene

CD80²

CD86 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13320942^1,2	C,H	--	119146664(+)	`TTAAAA/TTTCTC`	3	--	us2k¹		4	NS EA	420
rs77734710^1,2	C,	--	119146668(+)	`AATTCG/TCAAAT`	3	--	us2k¹		1	WA	2
rs11575855^1,2	C,F,	--	119147203(+)	`TTCTCT/CGTAGT`	3	--	us2k¹		3	WA CSA	122
rs74586663^1,2		--	119147356(+)	`CATACG/AAGGAA`	3	--	us2k¹		1	EA	120
rs72965462^1,2	C,	--	119147419(+)	`ACATCT/GATTAA`	3	--	us2k¹		2	WA	120
rs79111254^1,2	F,	--	119147723(+)	`TATTCT/CATTTT`	3	--	us2k¹		1	WA	118
rs72965464^1,2	C,	--	119147851(+)	`AGCTAC/TTGAAT`	3	--	us2k¹		2	WA	120
rs11575853^1,2	F,	--	119148072(+)	`CACAGA/GCACAC`	3	--	ut5¹		1	NA	120
rs2715263^1,2	C,A,H,	--	119149034(-)	`gattgT/Cgccac`	3	--	int¹		1	NA	2
rs113006438^1,2	C,	--	119149122(+)	`CGCCCG/ACCACC`	3	--	int¹		1	WA	2

HapMap Linkage Disequilibrium report for CD86 (121774213 - 121839983 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD86
1 CNV: 7357
Human Gene Mutation Database (HGMD): CD86

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD86

DNA2.0 Custom Variant and Variant Library Synthesis for CD86

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD86 for disorders           About GeneDecksing

OMIM gene information: 601020    OMIM disorders: --

20/112 diseases for CD86 (see all 112):    About MalaCards

b-cell non-hodgkin lymphoma common variable immunodeficiency hypersensitivity reaction type ii disease non-hodgkin lymphoma

wegener's granulomatosis graft versus host disease chronic mucocutaneous candidiasis sclerosing cholangitis

myasthenia gravis primary sclerosing cholangitis vernal keratoconjunctivitis inflammatory bowel disease

optic neuritis connective tissue disease primary biliary cirrhosis chronic obstructive pulmonary disease

lupus erythematosus hodgkin's lymphoma b-cell lymphomas cholangitis

11 diseases from the University of Copenhagen DISEASES database for CD86:

Carcinoma Hypersensitivity reaction type II disease Tetanus Leukemia

Benign mesothelioma Colorectal cancer Asthma Melanoma

Arthritis Multiple sclerosis Connective tissue disease

10/61 Novoseek disease relationships for CD86 gene (see all 61) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	54.7	24	9003248 (1), 10209502 (1), 17530637 (1), 17371857 (1) (see all 23)
tumors	40.2	54	10352284 (5), 7543078 (3), 12195617 (2), 9139887 (2) (see all 37)
hypersensitivity contact	32.6	1	10552213 (1)
lupus erythematosus systemic	31.3	4	11196673 (2), 15870153 (2)
multiple sclerosis	25.4	10	16513684 (2), 10227430 (1), 15544628 (1), 12672403 (1) (see all 6)
malignant ascites	24.2	3	10606960 (2), 9719501 (1)
autoimmune diseases	23.6	9	10201965 (1), 15870153 (1), 12223069 (1), 7500044 (1) (see all 5)
goiter nodular	21	2	15504312 (1), 16220002 (1)
granuloma	19.2	10	8686742 (4), 10461083 (2), 15019278 (2), 14518246 (1) (see all 5)
sjogrens syndrome	14.4	1	11302869 (1)

Genetic Association Database (GAD): CD86
Human Genome Epidemiology (HuGE) Navigator: CD86 (42 documents)

Export disorders for CD86 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD86 gene, integrated from 9 sources (see all 604):
(articles sorted by number of sources associating them with CD86)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PubMed id 12606712)^{1, 2, 9} Zhang X....Nathenson S.G. (2003)
Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). (PubMed id 7541777)^{1, 2, 9} Jellis C.L.... Gray G.S. (1995)
Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PubMed id 16223675)^{1, 4, 9} Marin L.A....Alvarez-Lopez M.R. (2005)
Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PubMed id 15942292)^{1, 4, 9} Handa T....Mishima M. (2005)
New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)^{1, 4, 9} Matsushita M....Tokunaga K. (2000)
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. (PubMed id 7694363)^{1, 2, 9} Freeman G.J.... Nadler L.M. (1993)
Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)^{1, 4, 9} Teutsch S.M....Stewart G.J. (2004)
c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PubMed id 12582153)^{1, 2, 9} Goto E.... Hotta H. (2003)
Identification of an alternatively spliced variant of human CD86 mRNA. (PubMed id 11162656)^{1, 2, 9} Magistrelli G....Delneste Y. (2001)
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. (PubMed id 11279501)^{1, 2, 9} Schwartz J.C....Almo S.C. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 942	HGNC: 1705	AceView: CD86	Ensembl:ENSG00000114013	euGenes: HUgn942
ECgene: CD86	Kegg: 942	H-InvDB: CD86

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD86	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD86	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CD86

Intellectual Property for CD86 gene
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Patent Information for CD86 gene:
Search GeneIP for patents involving CD86

GeneCards and IP:
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