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Aliases for CD84 Gene

Aliases for CD84 Gene

  • CD84 Molecule 2 3 5
  • Signaling Lymphocytic Activation Molecule 5 3 4
  • Leukocyte Differentiation Antigen CD84 3 4
  • CD84 Antigen (Leukocyte Antigen) 2 3
  • Cell Surface Antigen MAX.3 3 4
  • Hly9-Beta 3 4
  • SLAMF5 3 4
  • Leucocyte Differentiation Antigen CD84 3
  • Leukocyte Antigen CD84 3
  • SLAM Family Member 5 3
  • CD84 Antigen 4
  • HCD84 3
  • MCD84 3
  • LY9B 3

External Ids for CD84 Gene

Previous GeneCards Identifiers for CD84 Gene

  • GC01M158307
  • GC01M156248
  • GC01M157293
  • GC01M157732
  • GC01M157328
  • GC01M158777
  • GC01M131867

Summaries for CD84 Gene

Entrez Gene Summary for CD84 Gene

  • This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for CD84 Gene

CD84 (CD84 Molecule) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF7.

UniProtKB/Swiss-Prot for CD84 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).

Gene Wiki entry for CD84 Gene

Additional gene information for CD84 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD84 Gene

Genomics for CD84 Gene

Regulatory Elements for CD84 Gene

Enhancers for CD84 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H160565 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +11.6 11609 5 HDGF BATF ZNF766 EGR1 ATF7 ETV6 RUNX3 CREM CBFB JUNB CD84 VANGL2 SLAMF6 ATP1A4 SLAMF1 LY9 CD48 LOC105371468
GH01H160538 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.9 +37.9 37892 7 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 CBX5 ZNF143 ZNF207 REST CD84 SLAMF1 VANGL2 PPOX ENSG00000228863 SLAMF8 TSTD1 SLAMF6 CD48 DCAF8
GH01H160605 1.4 Ensembl ENCODE dbSUPER 17 -27.8 -27789 3 ELF3 HDGF FOXA2 TBL1XR1 RB1 ARNT KLF17 BMI1 BATF RAD21 VANGL2 CD84 ENSG00000228863 SLAMF6 SLAMF1 RNU4-42P LOC646347
GH01H160436 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +141.5 141455 2 PKNOX1 IRF2 TAL1 BACH1 RBBP5 CEBPG BATF GATA3 GATA2 RUNX3 SLAMF6 USP21 SLAMF1 PPOX CD84 VANGL2 ENSG00000228863 ITLN1 LY9 CD48
GH01H160573 1.5 FANTOM5 ENCODE dbSUPER 8.2 +2.6 2580 6 PKNOX1 RB1 ARNT SIN3A BMI1 ZBTB40 ZNF766 ELK1 EGR1 FOS SLAMF7 VANGL2 SLAMF6 SLAMF1 CD84 CD48 CD244 ATP1A4 LOC105371468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD84 on UCSC Golden Path with GeneCards custom track

Promoters for CD84 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014568 516 1201 PKNOX1 RB1 ARNT ZBTB40 ZNF766 FOS ZBTB11 JUNB REST ZNF592

Genomic Location for CD84 Gene

Chromosome:
1
Start:
160,541,094 bp from pter
End:
160,579,516 bp from pter
Size:
38,423 bases
Orientation:
Minus strand

Genomic View for CD84 Gene

Genes around CD84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD84 Gene

Proteins for CD84 Gene

  • Protein details for CD84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIB8-SLAF5_HUMAN
    Recommended name:
    SLAM family member 5
    Protein Accession:
    Q9UIB8
    Secondary Accessions:
    • B2R8T1
    • B7Z3R8
    • O15430
    • O95266
    • O95660
    • Q5H9R1
    • Q6FHA8
    • Q8WLP1
    • Q8WWI8
    • Q9UF04
    • Q9UIB6
    • Q9UIB7
    • Q9UIT7

    Protein attributes for CD84 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    • Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/EAT-2. Interacts with tyrosine-protein phosphatases PTPN6/SHP-1 and PTPN11//SHP-2 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. Interacts (via phosphorylated ITSM 1 and 2) with INPP5D/SHIP1.

    Three dimensional structures from OCA and Proteopedia for CD84 Gene

    Alternative splice isoforms for CD84 Gene

neXtProt entry for CD84 Gene

Post-translational modifications for CD84 Gene

  • N-glycosylated.
  • Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.
  • Ubiquitination at Lys122, Lys303, and Lys308
  • Glycosylation at posLast=150150 and Asn201
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CD84 Gene

Domains & Families for CD84 Gene

Protein Domains for CD84 Gene

Suggested Antigen Peptide Sequences for CD84 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIB8

UniProtKB/Swiss-Prot:

SLAF5_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
genes like me logo Genes that share domains with CD84: view

Function for CD84 Gene

Molecular function for CD84 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).

Phenotypes From GWAS Catalog for CD84 Gene

Gene Ontology (GO) - Molecular Function for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12928397
genes like me logo Genes that share ontologies with CD84: view
genes like me logo Genes that share phenotypes with CD84: view

Animal Models for CD84 Gene

MGI Knock Outs for CD84:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD84

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD84
  • Applied Biological Materials Clones for CD84
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD84 Gene

Localization for CD84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD84 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD84 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9310491
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD84: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD84 Gene

Pathways & Interactions for CD84 Gene

genes like me logo Genes that share pathways with CD84: view

Pathways by source for CD84 Gene

Gene Ontology (GO) - Biological Process for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9310491
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS 7797269
genes like me logo Genes that share ontologies with CD84: view

No data available for SIGNOR curated interactions for CD84 Gene

Drugs & Compounds for CD84 Gene

(2) Drugs for CD84 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma 408
genes like me logo Genes that share compounds with CD84: view

Transcripts for CD84 Gene

Unigene Clusters for CD84 Gene

CD84 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD84
  • Applied Biological Materials Clones for CD84
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD84 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CD84 Gene

GeneLoc Exon Structure for
CD84
ECgene alternative splicing isoforms for
CD84

Expression for CD84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD84 Gene

This gene is overexpressed in Spleen (x5.7) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for CD84 Gene

This gene is overexpressed in Urine (20.5), Peripheral blood mononuclear cells (18.2), Platelet (17.6), and Serum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD84 Gene



Protein tissue co-expression partners for CD84 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD84 Gene:

CD84

SOURCE GeneReport for Unigene cluster for CD84 Gene:

Hs.398093

mRNA Expression by UniProt/SwissProt for CD84 Gene:

Q9UIB8-SLAF5_HUMAN
Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.

Evidence on tissue expression from TISSUES for CD84 Gene

  • Blood(4.5)
  • Nervous system(4.1)
  • Lymph node(2.3)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with CD84: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD84 Gene

Orthologs for CD84 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD84 33 34
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia CD84 33 34
  • 82.52 (n)
dog
(Canis familiaris)
Mammalia CD84 33 34
  • 78.9 (n)
mouse
(Mus musculus)
Mammalia Cd84 33 16 34
  • 75.26 (n)
rat
(Rattus norvegicus)
Mammalia Cd84 33
  • 73.22 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
ManyToMany
Species where no ortholog for CD84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD84 Gene

ENSEMBL:
Gene Tree for CD84 (if available)
TreeFam:
Gene Tree for CD84 (if available)

Paralogs for CD84 Gene

Paralogs for CD84 Gene

(3) SIMAP similar genes for CD84 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD84 Gene

genes like me logo Genes that share paralogs with CD84: view

Variants for CD84 Gene

Sequence variations from dbSNP and Humsavar for CD84 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000073501 -- 160,554,570(+) AATTG(C/T)ATAAT intron-variant
rs1000319937 -- 160,569,526(+) CACAC(A/G)CACAC intron-variant
rs1000327495 -- 160,553,730(+) GAAGG(C/T)TTTGG intron-variant
rs1000370673 -- 160,557,021(+) TGAGA(-/T)TTTTT intron-variant
rs1000475171 -- 160,564,180(+) TTTTA(C/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD84 Gene

Variant ID Type Subtype PubMed ID
nsv831703 CNV gain 17160897

Variation tolerance for CD84 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD84 Gene

Disorders for CD84 Gene

Relevant External Links for CD84

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD84

No disorders were found for CD84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD84 Gene

Publications for CD84 Gene

  1. CD84 leukocyte antigen is a new member of the Ig superfamily. (PMID: 9310491) de la Fuente MA … Engel P (Blood 1997) 2 3 4 22 60
  2. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PMID: 15245368) Romero X … Engel P (Tissue antigens 2004) 3 4 22 60
  3. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PMID: 12928397) Tangye SG … van de Weerdt BC (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 22 60
  4. CD84 expression on human hematopoietic progenitor cells. (PMID: 12962726) Zaiss M … Hennemann B (Experimental hematology 2003) 3 4 22 60
  5. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PMID: 11414741) Lewis J … Duckett CS (Clinical immunology (Orlando, Fla.) 2001) 3 4 22 60

Products for CD84 Gene

  • Addgene plasmids for CD84

Sources for CD84 Gene

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